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Agenda

Day 1: December 15, Wednesday
7:30 a.m. Registration & Continental Breakfast
7:45 a.m. - 8:15 a.m. Informal NIH - ESP Executive Session
Room: Lincoln
8:30 a.m. Welcome and Programmatic Items
8:45 a.m. GTEx Goals and Milestones - Jeff Struewing, NHGRI
Briefly review GTEx goals, milestones and overall project timeline
MILESTONE 1 – Donor Enrollment
9:00 a.m. Donor Demographics and Clinical Data - Carolyn Compton, caHUB
Donor enrollment rates, projections; donor summaries
9:30 a.m. GTEx Donor Consent Sub-Study - Laura Siminoff, VCU
Preliminary results
10:00 a.m. Milestone 1: Discussion and Q&A Session
10:30 a.m. Coffee Break
MILESTONE 2 – Molecular and Tissue Quality
10:45 a.m. Molecular Quality - Kristen Ardlie, Broad Institute, Wendy Winckler, Broad Institute
Summary of sample RINs and yield trends; gene expression metrics
11:15 a.m. GTEx Project - Pathology Resource Center Update - Les Sobin, caHUB
Summary of histopathological findings and RIN analysis
11:45 a.m. Milestone 2: Discussion and Q&A Session
12:15 p.m. Lunch (boxed or on own)
MILESTONE 3 – Statistical Analyses
1:00 p.m. eQTL Analyses - David Deluca, Broad Institute, Gad Getz, Broad Institute
Preliminary eQTL analyses; collaboration plans with Statistical Methods R01s
What would be the most compelling preliminary eQTL results?
1:30 p.m. GTEx Data Release - Taylor Young, Broad Institute, Simona Volpi, NHGRI
2:00 p.m. Milestone 3: Statistical Methods Discussion and Q&A Session
2:30 p.m. Wrap-up /Action Items Summary - Simona Volpi, NHGRI
3:00 p.m. Coffee Break - General Session ADJOU
3:15 p.m. Suggested informal discussions
Room: Regency (main room)
A. BSS quality metrics going forward
B. Analysis pipeline - Broad/Statistical methods PIs
  • Analysis plan discussion
  • Scale-up power considerations - how large should a scale-up be?
3:30 p.m. NIH – ESP Executive Session
Room: Lincoln
Day 2: Friday, December 2, 2011
8:00 a.m. Continental Breakfast
8:30 a.m. Impressions from ESP/Programmatic Items - Su Koester, NIMH
9:00 a.m. Biospecimen Methodological Study - Chana Rabiner, caHUB
9:30 a.m. Group Discussions

A. Biospecimen Collection
Moderators: Les Sobin and Jeff Thomas
Room: Regency (main room)

Procurement issues

  • Fixation
  • Doubling of aliquots (contiguous samples)
  • Sampling problems (fat, mucosa vs muscle, etc)
  • Fixation-stabilization ‘mix-up’

Proposed modification of tissue procurement

  • Tissues to be eliminated and added

B. Data Collection
Moderators: Barbara Foster, Sherilyn Sawyer and Laura Siminoff
Room: Lincoln

  • Time of data collection
  • Elements of difficult abstraction
  • Additional elements to consider
  • Consent - Problems or issues in obtaining consent for GTEx participation

C. Data Analysis
Moderators: Gad Getz
Room: Randolph

10:15 a.m. Coffee Break and time for checkout
10:45 a.m. Group Discussions

D. Biospecimen Logistics
Moderators: Steve Buia, Dan Rohrer and Scott Jewel
Room: Regency (main room)

  • Handling
  • Timelines
  • Workflow
  • Lessons learned as relate to scale-up

E. Informatics and data transfer
Moderators: Alex Thompson, Taylor Young and Charlie Shive
Room: Lincoln

  • Review of current data flow
  • Discussion of project analysis
  • Lessons learned as relate to scale-up
  • trategic planning discussion
  • What needs to be done to have a cleaned set of data for submission to dbGaP
11:30 a.m. Break - Working Group Summaries & Wrap-Up
10-min presentations by moderators + 5-min Q&A
12:30 p.m. Summary of GTEx’s next steps - Jeff Struewing, NHGRI
1:00 p.m. ADJOURN - Thank you
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