Funded Research

The Single Cell Analysis Program (SCAP) has transitioned from Common Fund support in 2017. For more information, please visit https://commonfund.nih.gov/singlecell/. Please note that since SCAP is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis. 

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)
PA-13-140
PI Name Institution Name Title
BELL, CALEB B (contact)
RUTT, BRIAN KEITH		 BELL BIOSYSTEMS, INC. Single Cell Spatiotemporal and Functional Reporting using Magneto-Endosymbionts
DOBES, NICHOLAS CARL CELL MICROSYSTEMS, INC. CellRaft Arrays for Single-cell PCR
HEYMAN, JOHN A SPHEREBIO, INC. Droplet-based Analysis of Secretion and Sorting (DASS) for characterization and selection of individual immune cells
HUANG, CHANGJIN INFINITESIMAL, LLC High-Throughput Microdevice for Temporal Single-Cell Analysis
SCOUTEN, CHARLES WILLIAM (contact)
SCHWEIZER, FELIX
SUN, YING		 ROKHAN, LLC Cellular Capacitance Monitoring Integration into Digital Patch Clamp Amplifier
YEAKLEY, JOANNE MULLIGAN BIOSPYDER TECHNOLOGIES, INC. Multiplexed mRNA and miRNA Profiling of Single Cells

 

Revisions to Add Single Cell Analysis to Active Research Projects (U01)
RFA-RM-13-023
PI Name Institution Name Title
FRAZER, KELLY A (contact)
CHI, NEIL C
EVANS, SYLVIA M
YEO, EUGENE WEI-MING
ZHANG, KUN		 UNIVERSITY OF CALIFORNIA SAN DIEGO Regulatory Genomic Studies in a Cohort of IPS Cell Derived Cardiomyocytes

 

Revisions to Add Single Cell Analysis to Active Research Projects (R01)
RFA-RM-13-022​  
PI Name Institution Name Title
CHANG, JOHN T UNIVERSITY OF CALIFORNIA SAN DIEGO Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
CHEN, C CASEY UNIVERSITY OF SOUTHERN CALIFORNIA Novel clone-specific virulence determinants of A. actinomycetemcomitans 
KRAUSE, DIANE S YALE UNIVERSITY Mechanisms of megakaryocyte maturation
RAO, DINESH S UNIVERSITY OF CALIFORNIA LOS ANGELES Characterizing tumor suppressive functions of microRNAs in B-cell neoplasia
ROTHENBERG, ELLEN V. (contact)
CAI, LONG		 CALIFORNIA INSTITUTE OF TECHNOLOGY Genomic site binding rules and regulatory factor function in developing T cells
SHIVDASANI, RAMESH A DANA-FARBER CANCER INST Multidimensional characterization of RNAs and signals in single intestinal cells
TENEN, DANIEL G BETH ISRAEL DEACONESS MEDICAL CENTER Molecular biology of myeloid differentiation
WU, CATHERINE JU-YING DANA-FARBER CANCER INST Personal tumor neoantigens for immunity against chronic lymphocytic leukemia

 

Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21)
RFA-RM-13-021​
PI Name Institution Name Title
CAI, DAWEN (contact)
YE, BING		 UNIVERSITY OF MICHIGAN MACS: A genetic labeling tool to depict the complete neuroblast lineage of all neurons in individual Drosophila brains
CHENG, JI-XIN PURDUE UNIVERSITY WEST LAFAYETTE Microsecond Raman spectroscopy: Assessing single cell metabolism in a vital organism
GARTNER, ZEV JORDAN UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Identifying the intercellular networks regulating estrogen receptor expression with a high definition single cell printer
NEMES, PETER GEORGE WASHINGTON UNIVERSITY In Situ Optoguided Microsampling Single-cell Mass Spectrometry for Elucidating Cell Heterogeneity
PARANT, JOHN M UNIVERSITY OF ALABAMA AT BIRMINGHAM Light-Induced Genetic Alterations within Single Cell of a Live Vertebrate Animal
PERRIMON, NORBERT HARVARD MEDICAL SCHOOL Innovative reporters to characterize heterogeneous states among cells
PRATX, GUILLEM STANFORD UNIVERSITY Real-time tracking of single cells in live animals
ZARE, RICHARD N STANFORD UNIVERSITY High Spatiotemporal Resolution Mass Spectrometry for Single Cell Analysis 

 

Validation and Advanced Development of Technologies for the Study of Biological Properties of Single Cells (R33)
RFA-RM-13-020
PI Name Institution Name Title
HOLLEY, SCOTT A YALE UNIVERSITY Quantification and modeling of the emergence of tissue-level mechanics from individual cell heterogeneity
HUANG, BO UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Analyzing genomic elements in live animals by CRISPR imaging
HUANG, TONY JUN PENNSYLVANIA STATE UNIVERSITY-UNIV PARK Validation of acoustic tweezers for single-cell analyses of purine metabolism
NORRIS, JEREMY L VANDERBILT UNIVERSITY Laser-Based Mass Spectrometry Analysis of Single Cells
RAJ, ARJUN UNIVERSITY OF PENNSYLVANIA Validation and development of single nucleotide variant RNA FISH in single cells in culture and tissue
SOUSA-NEVES, RUI (contact)
MIZUTANI, CLAUDIA		 CASE WESTERN RESERVE UNIVERSITY Multidimensional analysis of cell lineages
SUL, JAI-YOON UNIVERSITY OF PENNSYLVANIA Nuclear pre-mRNA analysis of single cells in brain slice
YOUNG-PEARSE, TRACY L BRIGHAM AND WOMEN'S HOSPITAL Detection of cell type specific effects of pathway manipulation in neural cells 

 

Accelerating the Integration and Translation of Technologies to Characterize Biological Processes at the Single Cell Level (R01)
RFA-RM-11-015
PI Name Institution Name Title
BAO, ZHIRONG SLOAN-KETTERING INSTITUTE FOR CANCER RES An integrated system to monitor complex tissues at single-cell resolution
BOYDEN, EDWARD S. (contact)
FOREST, CRAIG
ZENG, HONGKUI		 MASSACHUSETTS INSTITUTE OF TECHNOLOGY High-throughput robotic analysis of integrated neuronal phenotypes
BUSHKIN, YURI (contact)
GENNARO, MARIA LAURA
TYAGI, SANJAY		 UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL Rapid Analysis of Single T Cell Immunity Signatures in Tuberculosis
CAI, LONG (contact)
SOMLO, GEORGE		 CALIFORNIA INSTITUTE OF TECHNOLOGY Multiplex RNA imaging in single cells by superresolution microscopy& barcode FISH
GERDES, MICHAEL (contact)
COFFEY, ROBERT J.
SHAIKH, KASHAN		 GENERAL ELECTRIC GLOBAL RESEARCH CTR Validation of a single cell multiplexed in-situ biomarker analysis platform for p
LOVE, JOHN CHRISTOPHER MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nanowell-based single-cell technology for characterizing clinical samples ex vivo
MAYFORD, MARK R. SCRIPPS RESEARCH INSTITUTE Activity Based Tagging of Neurons
VARADARAJAN, NAVIN (contact)
COOPER, LAURENCE J.N.		 UNIVERSITY OF HOUSTON Quantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy
WIRTZ, DENIS JOHNS HOPKINS UNIVERSITY Single-cell phenotyping for therapeutic stratification in pancreatic cancer

 

Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21)
RFA-RM-11-014
PI Name Institution Name Title
COVERT, MARKUS W STANFORD UNIVERSITY New methods for monitoring the immune system, in individual cells and in vivo
DENISENKO, OLEG N UNIVERSITY OF WASHINGTON Single cell analysis of chromatin changes at individual genes
KARTALOV, EMIL P UNIVERSITY OF SOUTHERN CALIFORNIA High-Throughput Single-Cell-PCR Technique for Tissue Analysis of Genetic Heteroge
KIRSCHNER, MARC WALLACE HARVARD UNIVERSITY (MEDICAL SCHOOL) A high-throughput method for simultaneous profiling of mRNA and protein levels in
KONRY, TALI TANIA MASSACHUSETTS GENERAL HOSPITAL Development of Microfluidic Nano-Liter Platform for Single Cell Dynamic Monitorin
LEVY, MATTHEW (contact)
SNAPP, ERIK L.		 ALBERT EINSTEIN COL OF MED YESHIVA UNIV Fluorescent probes for quantitation of secretory protein levels in single cells
LOVE, JOHN CHRISTOPHER MASSACHUSETTS INSTITUTE OF TECHNOLOGY Highly Multiplexed Single-cell Transcript Analysis Using DNA-barcoded Nanowells
MELDRUM, DEIRDRE R. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS In Situ Single Cell Laser Lysis and Downstream qRT-PCR Profiling
MIZUTANI, CLAUDIA (contact)
GUO, WEIHONG
SOUSA-NEVES, RUI		 CASE WESTERN RESERVE UNIVERSITY Real-time visualization of neural stem cell transcriptome
MURRAY, KERMIT KING LOUISIANA STATE UNIV A&M COL BATON ROUGE Nanoscale Laser Ablation Capture Mass Spectrometry for Single Cell Proteomics
NAVIN, NICHOLAS UNIVERSITY OF TEXAS MD ANDERSON CAN CTR Developing a whole-genome sequencing method for single human cells
NEU, COREY P PURDUE UNIVERSITY WEST LAFAYETTE Combined Biophysical and Biochemical Study of Single Cells
RESHETNYAK, YANA K. (contact)
ANDREEV, OLEG A		 UNIVERSITY OF RHODE ISLAND Mapping pH at the surface of individual cell
SIMS, PETER ALAN COLUMBIA UNIVERSITY HEALTH SCIENCES Multiplexed, Single Molecule Protein Identification for Single Cell Proteomics
WANG, YINGXIAO UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN A Systematic Approach to Engineer Fyn Kinase Biosensor

 

Studies to evaluate cellular heterogeneity using transcriptional profiling of single cells (U01)
RFA-RM-11-013
PI Name Institution Name Title
EBERWINE, JAMES H (contact)
KIM, JUNHYONG		 UNIVERSITY OF PENNSYLVANIA Role of Single Cell mRNA Variation in Systems Associated Electrically Excitable C
KNOWLES, JAMES A (contact)
CHOW, ROBERT HSIU-PING		 UNIVERSITY OF SOUTHERN CALIFORNIA Evaluation of Cellular Heterogeneity Using Patchclamp and RNA-Seq of Single Cells
ZHANG, KUN UNIVERSITY OF CALIFORNIA SAN DIEGO Single-cell sequencing and in situ mapping of RNA transcripts in human brains

This page last reviewed on October 13, 2017