Enhancer TherapyEnhancer Therapy

​The image illustrates a cell-specific enhancer at left that drives expression of a broadly expressed gene at right. By targeting cell-specific enhancer RNAs (eRNAs), it may be possible to reduce expression of essential, broadly expressed genes in a cell-specific manner, thereby enabling a new therapeutic approach to cancer and metabolic disease. PU.1 – binding location of the macrophage-lineage determining transcription factor PU.1. H3K4me2 – location of a histone modification associated with enhancer activity.