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Membrane Protein Productionfor Structure Determination(R01)
RFA-RM-09-012
PI Name Institution Name Title
BETENBAUGH, MICHAEL J JOHNS HOPKINS UNIVERSITY Evolving Membrane Proteins for High Level Expression in Modified Mammalian Cells
CARRAGHER, BRIDGET OLIVIA SCRIPPS RESEARCH INSTITUTE A Helical Crystallization Pipeline for Membrane Protein Structure by TEM
CHOE, SENYON SALK INSTITUTE FOR BIOLOGICAL STUDIES Cell-Free Expression of Human Integral Membrane Proteins for Structural Studies
DELUCAS, LAWRENCE J UNIVERSITY OF ALABAMA AT BIRMINGHAM Production & Crystallization of Membrane Protein for 3D Structure
FROMME, PETRA. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Femtosecond Nano-Crystallography of Membrane Proteins
GENNIS, ROBERT B UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Using Extreme Thermophiles for the Homologous Expression of Membrane Proteins
GUAN, LAN TEXAS TECH UNIVERSITY HEALTH SCIS CENTER Novel Capture Reagents for Membrane Protein Structure Determination
IVERSON, T M VANDERBILT UNIVERSITY Stabilization of Membrane Protein Signaling Complexes
MAYNARD, JENNIFER A UNIVERSITY OF TEXAS AUSTIN Engineered Antibody Fragments for Co-Crystallization with Signal Peptide Peptidase
RAMAMOORTHY, AYYALUSAMY UNIVERSITY OF MICHIGAN AT ANN ARBOR Rapid and Efficient Production of Functional Cytochrome P450 Enzymatic Complexes
STOKES, DAVID L NEW YORK STRUCTURAL BIOLOGY CENTER High Throughput Pipeline for Electron Crystallography
WOYCHIK, NANCY ANN UNIV OF MED/DENT NJ-R W JOHNSON MED SCH Membrane Protein Production Using the Yeast SPP System

 

Membrane Protein Production and Structure Determination (R01)
(RFA-RM-07-003)
PI Name Institution Name Title
ALLEN, PAUL D. BRIGHAM AND WOMEN'S HOSPITAL Integral Membrane Protein Overexpression Using Organ Bioreactors
BOWIE, JAMES U. UNIVERSITY OF CALIFORNIA LOS ANGELES Improving Membrane Protein Crystallization
DELUCAS, LAWRENCE UNIVERSITY OF ALABAMA AT BIRMINGHAN Innovative Methods for Membrane Protein Crystallization
NAVARRO, JAVIER V. UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Structural Biology of G Protein-Coupled Receptors
SANDERS, CHARLES R. VANDERBILT UNIVERSITY. Overcoming the Barriers to Structural Analysis of GPCRs
SPILLER, BENJAMIN W. VANDERBILT UNIVERSITY Structural Studies of Voltage Gating in Voltage-Gated Sodium Channels
STOKES, DAVID L. NEW YORK STRUCTURAL BIOLOGY CENTER Membrane Protein Structure by Electron Crystallography

 

Membrane Protein Production and Structure Determination (R01- R21- P01)
RFA-RM-04-026
PI Name Institution Name Title
BOWIE, JAMES U UNIVERSITY OF CALIFORNIA LOS ANGELES Generation of Membrane Protein Production Strains
CAFFREY, MARTIN D. UNIVERSITY OF LIMERICK RESEARCH FDN Membrane Proteins. Crystallogenesis and X-ray Structure
GERFEN, GARY J. YESHIVA UNIVERSITY Proton Crystallography of Membrane Proteins Using High Frequency ENDOR
GROS, PHILIPPE MC GILL UNIVERSITY Expression of ABC Transporters in Pichia Pastoris
HIMANEN, JUHA P SLOAN-KETTERING INSTITUTE FOR CANCER RES Expression and Structural Study of Eph Receptor Kinases
HUNT, JOHN F COLUMBIA UNIV NEW YORK MORNINGSIDE A Chemical Genetics Approach to Improved IMP Expression in E. Coli
ISMAGILOV, RUSTEM F UNIVERSITY OF CHICAGO Enabling Nanoliter Membrane Protein Crystallization
KENIS, PAUL J UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Innovative Methods for Membrane Protein Crystallization
KENT, STEPHEN B.H UNIVERSITY OF CHICAGO A Systematic Approach to the Chemical Synthesis of G-Protein Coupled Receptors
KOBILKA, BRIAN K STANFORD UNIVERSITY Chimeric Proteins to Enhance Crystal Formation of G Protein Coupled Receptors
LAIBLE, PHILIP D UNIVERSITY OF CHICAGO Reagents: Promote Membrane Protein Stability and Crystallization
LOLL, PATRICK J DREXEL UNIVERSITY COLLEGE OF MEDICINE Mapping the Crystallization Slot for Membrane Proteins
MARASSI, FRANCESCA M BURNHAM INSTITUTE Structure of a Beta Barrel Membrane Protein in Lipid Bilayer Membranes
MILLIGAN, RONALD A SCRIPPS RESEARCH INSTITUTE ELECTRON MICROSCOPY OF MEMBRANE PROTEINS
OPELLA, STANLEY J UNIVERSITY OF CALIFORNIA SAN DIEGO Membrane Protein Structures in Phospholipid Bilayers by Solid State NMR
RIENSTRA, CHAD M UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Structure and Function of Membrane Protein Complexes by Solid State NMR
WAGNER, GERHARD HARVARD UNIVERSITY (MEDICAL SCHOOL) Expression, Labeling and NMR Structure Determination of Integral Membrane Protein
WANG, DA-NENG NEW YORK UNIVERSITY SCHOOL OF MEDICINE Crystallization of Neurotransmitter Transporter Homologs
WIENER, MICHAEL C. UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Improved Methods for Membrane Protein Crystallization

 

Centers for Innovation in Membrane Protein Production for Structure Determination (P50)
RFA-RM-08-019
PI Name Institution Name Title
CRAMER, WILLIAM A. PURDUE UNIVERSITY WEST LAFAYETTE Improving Rate/Quality Limitations in Membrane Protein Structure Determination
STEVENS, RAYMOND C. SCRIPPS RESEARCH INSTITUTE Joint Center for Integral Membrane Protein Technologies-Complexes (JCIMPT-Complexes)
STROUD, ROBERT M. UNIVERSITY OF CALIFORNIA SAN FRANCISCO Membrane Protein Expression Center (MPEC)

 

Centers for Innovation in Membrane Protein Production (P50)
RFA-RM-04-009
PI Name Institution Name Title
STEVENS, RAYMOND C SCRIPPS RESEARCH INSTITUTE JCSG Center for Innovative Membrane Protein Technologies
STROUD, ROBERT M UNIVERSITY OF CALIFORNIA SAN FRANCISCO Center for Innovation in Membrane Protein Production
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