We Accelerate Discovery

You are here


Program Snapshot

All organs in the body are stimulated by nerves, which send signals that affect the organ’s function. Modulation of nerve signals to control organ function has recently been recognized as a potentially powerful way to treat many diseases and conditions, such as hypertension, heart failure, gastrointestinal disorders, type II diabetes, inflammatory disorders, and more. However, the mechanisms of action for therapies in which nerves are stimulated to control organ function are poorly understood. The Common Fund’s Stimulating Peripheral Activity to Relieve Conditions (SPARC) has the central goal of interrogating and elucidating peripheral autonomic and sensory control of internal organ function to catalyze development of more effective and minimally invasive neuromodulation therapies. SPARC is uniquely positioned to serve as a community resource that provides the broader public and private research communities with the scientific foundation necessary to advance neuromodulation therapies towards precise neural control of organ function to treat diseases and conditions.

Read more…



Program Highlights

Explore the ways in which SPARC and other research organizations use the peripheral nervous system to treat or control a wide range of conditions including migraines, type 2 diabetes and heart failure.

Discover why recent investments, such as the SPARC program, and successful trials using nerves in the foot or ankle to treat overactive bladder syndrome and chronic pelvic pain herald a shift from traditional medications to neuromodulation therapies.

Learn how programs like SPARC may alleviate conditions such as rheumatoid arthritis and inflammatory bowel disease by controlling electrical impulses to the spleen.

During the 2013-2014 Common Fund strategic planning process, the NIH community identified the need to understand the mechanisms of action for neuromodulation therapies. Although some neuromodulation therapies are in use, the underlying technologies are not optimal, and so a great opportunity exists to develop improved therapies for a number of diseases and conditions. Improving and developing new neuromodulation therapies requires a better understanding of the neural circuits in end-organ systems, as well as the development of novel electrode designs, surgical procedures, and stimulation protocols. In response to these needs and opportunities, the Common Fund plans to launch the SPARC program in fiscal year 2015.

2016 Other Transaction (OT2) and Cooperative Agreement (U18) Awards

28 awards issued which span 8 target organ/organ systems



Please click the color-coded shapes below to view individual awardee abstracts and be aware that some projects span multiple target areas.


Red Triangle

Red Circle

Red Trapezoid

Red Trapezoid



Light Blue Triangle

Light Blue Circle

Light Blue Trapezoid

Light Blue Hexagon



Yellow Triangle

Yellow Circle

Yellow Circle

Yellow Trapezoid

Yellow Trapezoid

Yellow Trapezoid

Yellow Hexagon

Small and Large Intestine/Colon

Dark Gray Triangle

Dark Gray Trapezoid

Dark Gray Trapezoid

Dark Gray Trapezoid


Adipose Tissue

Pink Circle

Pink Circle





Light Gray Trapezoid





Bladder/Lower Urinary Tract

Dark Blue Circle

Dark Blue Trapezoid

Dark Blue Trapezoid

Dark Blue Trapezoid



Brown Circle

Brown Trapezoid

Brown Hexagon

















SPARC U18 FOAs and FAQsSPARC Other Transaction (OT) Funding Opportunity Announcements 
Component 1Anatomical and Functional Mapping of the Innervation of Major Internal Organs (now in Phase 1) is seeking projects that support a full, multi-expertise approach to comprehensively provide data for the detailed, predictive functional and anatomical neural circuit map for neural control of medically relevant functions of a specific organ and its functionally-associated structures.

  • (RFA-RM-15-003Pre-application: Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT1)
    See Application for Additional Receipt Date(s): Next due date is November 15, 2016.
  • (RFA-RM-15-018Limited Competition: Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2)
    Application Receipt Date(s): Not Applicable. Due date will be specified in the Invitation to Submit after successful competition of the corresponding OT1 (RFA-RM-15-003) application.

Component 2Next Generation Tools and Technologies (now in Phase 2) is seeking projects that develop new and/or enhance tools and technologies to elucidate the neurobiology and neurophysiology underlying autonomic control of organs in health or disease.

  • (RFA-RM-16-003Limited Competition:  Technologies to Understand the Control of Organ Function by the Peripheral Nervous System (OT2)
    Application Receipt Date(s): Not Applicable. Due date will be specified in the Invitation to Submit after successful competition of the corresponding OT1 (RFA-RM-16-002) application.

Component 3: Use of Existing Market-Approved Technology for New Market Indications is seeking projects that generate the necessary safety and efficacy data, through pre-clinical studies, to support new market indications for a limited set of neuromodulation devices (see Device Portal). 

  • (RFA-RM-16-027) SPARC: Pre-clinical Development of Existing Market-approved Devices to Support New Market Indications (U18)
    Application Receipt Date(s): Applications are due December 21, 2016 with Letters of Intent (LOIs) due November 21, 2016.

Component 4: Data Coordination, Mapping and Modeling Center will soon issue an OT funding opportunity to develop and implement a center that will use data generated by the various SPARC funded projects to produce neural circuit maps of the autonomic and sensory innervation of multiple organs or organ systems. It is anticipated that any team of investigators will include specific expertise in relevant mapping, data management and coordination, and multi-scale modeling methods and techniques.

  • (NOT-RM-16-032Soon to be Issued OT Funding Opportunity for SPARC: Data and Resource Center (OT3)
    Application Receipt Date(s): Not Applicable. Due date will be specified in the corresponding OT3 funding opportunity (RFA-RM-16-008).

FAQs for NOT-RM-16-032

1. Are applicants required to have a Dun and Bradstreet (D&B) Data Universal Numbering System (DUNS) number?

2. Is System for Award Management (SAM) registration required?

3. What are some of the important needs and challenges faced by an effort like the SPARC: Data and Resource Center?


Up to Top