Skip to main content
NIH Director's New Innovator Award logo.

2022 NIH Director's New Innovator Award (DP2) - RFA-RM-21-016

*Diversity Statement

PI Name Institution Name Title
ALAMBEIGI, FARSHID

 

UNIVERSITY OF TEXAS AT AUSTIN

 

A Novel Semi-Autonomous Surgeon-in-the-Loop In Situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss Injuries

 

AREY, RACHEL NICOLE

 

BAYLOR COLLEGE OF MEDICINE

 

Uncovering Brain-Wide Molecular Determinants of Individual Memory Performance Across Lifespan

 

BEYELER, MICHAEL

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Towards a Smart Bionic Eye: AI-Powered Artificial Vision for the Treatment of Incurable Blindness

 

BLAZECK, JOHN JAMES

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Synthetic Metabolism to Armor and Enhance a New Class of Cell Therapies

 

BUCKLEY, RACHEL FRANCES

 

MASSACHUSETTS GENERAL HOSPITAL

 

The Inactive X: Discovering Sex Genes That Influence Female Vulnerability to Alzheimers Disease

 

CASE, LINDSAY

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

New Insights Into the Molecular Regulation of Mechanotransduction

 

CHAN, MICHELLE

 

PRINCETON UNIVERSITY

 

Building a Systematic, Comprehensive Mammalian Cell Fate Map

 

CHANG, CHI-LUN

 

ST. JUDE CHILDREN'S RESEARCH HOSPITAL

 

Understanding Metabolism in Space and Time – Mechanistic Analysis of the Dynamic Spatial Organization of Metabolism

 

CHAVEZ, ALEJANDRO

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Methods to Rapidly Explore Combinatorial Diversity and Their Application to CRISPR-Cas9 Systems

 

CHEADLE, LUCAS M

 

COLD SPRING HARBOR LABORATORY

 

Neuroimmunological Insights Into Brain Development and Dysfunction: An Integrative Approach Focused on Microglial Dynamics

 

CHEN, XIAOYIN

 

ALLEN INSTITUTE

 

Unraveling the Developmental Logic of Cortical Long-Range Projections Using In Situ Sequencing-Based Neuroanatomy

 

CHRISTOPH, JAN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

AI-assisted Imaging and Prediction of Cardiac Arrhythmia Origins Using 4D Ultrasound

 

CLITES, TYLER R

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage

 

DELANEY, JOE R

 

MEDICAL UNIVERSITY OF SOUTH CAROLINA

 

Tumor Suppressor Vulnerability Conferred by Aneuploid Loss of Haploinsufficient Metallothionein Genes

 

DING, FANGYUAN

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Universally-Applicable RNA Mapping at Subcellular and Single-Base Resolution

 

ESCOBAR HOYOS, LUISA

 

YALE UNIVERSITY

 

Unleashing T-Cell Anti-Tumor Response Through Repair of Altered RNA Splicing and Antigen Mimicry Recognition

 

ESCOLANO, AMELIA

 

WISTAR INSTITUTE

 

Manipulating Epitope Immunodominance and Tracking B-cell-Antigen Interactions for Vaccine Design.

 

FEDER, ALISON F

 

UNIVERSITY OF WASHINGTON

 

A Phylodynamic Time Machine for Solid Tumors

 

FERGUSON, FLEUR MARCIA

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Chemical Control of Misfolded Protein Fate

 

FISHER, YVETTE E

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

How Does Neuromodulation Shape the Fluidity of Spatial Working Memory?

 

GADAGKAR, VIKRAM

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

The Female Songbird as a Novel Mechanistic Model for the Neural Basis of Social Evaluation

 

GARCIA QUIROZ, FELIPE

 

EMORY UNIVERSITY

 

Multifunctional Phase Sensors for Probing and Manipulation of Intracellular Biomolecular Condensates

 

GAUBLOMME, JELLERT

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Spacially Mapping of Pooled In Vivo CRISPR Screens in the Tumor Microenvironment 

 

GOLDBERG, EMILY LAUREN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Discovering Mechanisms of Tissue-Resident Immune Aging

 

GRANGER, ADAM

 

BROAD INSTITUTE, INC.

 

High-Throughput Methods for Measuring Cortical Synaptic Connectivity at Single-Cell Resolution

 

GRUBAUGH, NATHAN DALE

 

YALE UNIVERSITY

 

Enhancing Dengue Virus Genomic Surveillance to Uncover Circulating Genetic Diversity

 

HA, GAVIN

 

FRED HUTCHINSON CANCER CENTER

 

Translating the Tumor Regulome from Cell-Free DNA for Precision Oncology

 

HRVATIN, SINISA

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

 

Biology and Applications of Mammalian Hibernation-Like States

 

INAGAKI, HIDEHIKO

 

MAX PLANCK FLORIDA CORPORATION

 

A Novel Approach to Crack Neuronal Mechanisms that Shape Computations in the Brain

 

JIN, CHENGCHENG

 

UNIVERSITY OF PENNSYLVANIA

 

A Blueprint for Neutrophil Heterogeneity and Reprogramming in Cancer

 

JOGLEKAR, ALOK

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Signaling Via MHC: Engineering Immune Cells with New Capabilities

 

KLEINSTIVER, BENJAMIN PETER

 

MASSACHUSETTS GENERAL HOSPITAL

 

Scalable Development of Custom Genome Editing Technologies

 

KUANG, ZHENG

 

CARNEGIE-MELLON UNIVERSITY

 

Microbial Regulation of Mammalian Circadian Rhythms and the Sexual Dimorphism: From Metabolism to Immunity

 

KUNJAPUR, ADITYA MOHAN

 

UNIVERSITY OF DELAWARE

 

Boosting Efficacy of Oral Vaccine Candidates by Enabling Spore Display of Nitrated Antigens

 

KVON, EVGENY

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Deciphering the Mechanism of Long-Range Gene Regulation In Vivo

 

LAPINAITE, AUDRONE

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Engineering Novel Precision Genome Editing Tools

 

LI, ZHONGWEI

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

The Synthetic Kidney: A Revolutionary Solution for the Shortage of Kidneys for Transplantation

 

LIM, CI JI

 

UNIVERSITY OF WISCONSIN-MADISON

 

Unraveling the Telomere Black Box: A New Single-Molecule Approach to Define the Telomere Chromatin Landscape and its Functional Mechanisms

 

MAKINSON, CHRISTOPHER DONALD

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Unlocking the Postnatal Human Brain Using Activity Augmented Organoids

 

MANSOOR, STEVEN ELIAS

 

OREGON HEALTH & SCIENCE UNIVERSITY

 

Elucidation of P2X7 Receptor Signaling and Development of Novel Small Molecule and Aptamer Ligand Therapies

 

MCKENNA, AARON H

 

DARTMOUTH COLLEGE

 

Annotated Lineage Trees of Murine Development

 

MCKINLEY, KARA LAVIDGE

 

HARVARD UNIVERSITY

 

Life History of the Menstruating Uterus

 

MONK, ELLIS

 

HARVARD UNIVERSITY

 

The Optics of Health: Race Skin Tone Minority Health and Health Disparities in the U.S.

 

MOSALAGANTI, SHYAMAL

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

In-Situ Architecture of Membrane Contact Sites Mediating Organelle Fission

 

MOUSAVI, MARAL

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Building a Two-Way Communication System: Bio-Orthogonal Superhydrophobic Nanoparticles for Controlled Stimulation and Real-Time Sensing of Neurotransmitters

 

NATHAVITHARANA, RUVANDHI

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

THWART-TB: Testing Health Workers At Risk to Advance Our Understanding of TB Infection

 

NIA, HADI TAVAKOLI

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

Probing Functioning Lung at the Cellular Resolution in Health and Disease

 

NIEPA, TAGBO HERMAN ROLAND

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Designing A High-Throughput Platform to Bioprospect the Human Microbiome and Manipulate Its Interplay with Host Environments

 

OKAFOR, C DENISE

 

PENNSYLVANIA STATE UNIVERSITY, THE

 

Improving Drug Design to Eliminate Side Effects: From Computational to Animal Models

 

PEARL, REBECCA L

 

UNIVERSITY OF FLORIDA

 

Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma

 

PONCE, CARLOS RAMON

 

HARVARD MEDICAL SCHOOL

 

Defining Mechanisms for Natural Vision in the Primate Brain with Machine Learning

 

RAJ, BUSHRA

 

UNIVERSITY OF PENNSYLVANIA

 

Genomic Tools for Massively Parallel Recording of Signaling Activity at Cellular Resolution in a Brain-Wide Manner

 

RISCA, VIVIANA I

 

ROCKEFELLER UNIVERSITY

 

Cross-Regulation Between Loop Extrusion, Chromatin Fiber Structure and Chromatin-Associated RNAs

 

ROUSKIN, SILVIA

 

HARVARD MEDICAL SCHOOL

 

Constructing the Nest - Understanding the Mechanisms of Nidoviridae RNA Genomes Transcription and Recombination

 

SANULLI, SERENA

 

STANFORD UNIVERSITY

 

Harnessing the Chromatin Conformational Code for Epigenetic Regulation

 

SARKAR, DEBLINA

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Circulatronics: A New Paradigm for Biomedical Implants

 

SCHOENEBERG, JOHANNES

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Decode Mitochondrial Morphology Dynamics to Predict Cell Fate Decisions

 

SEN, DEBATTAMA RAI

 

MASSACHUSETTS GENERAL HOSPITAL

 

Dissecting the Enhancer Logic Governing Immune Cell Fate Decisions

 

SHI, XIAOYU

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Gel-based Optical-isolation Single-Cell 3D Spatial Multiomics

 

SKYLAR-SCOTT, MARK A

 

STANFORD UNIVERSITY

 

Trillion Cell Culture to Fuel Organ Biofabrication

 

SMEETON, JOANNA MARJORIE

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Deciphering Multi-Dcale Fifferentiation and Patterning Cues Driving Whole Craniofacial Joint Regeneration

 

SOZEN, BERNA

 

YALE UNIVERSITY

 

Deciphering Principles of Human Embryonic Patterning in Development and Disease

 

STAVISKY, SERGEY

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

Understanding and Restoring Speech Production Using an Intracortical Brain-Computer Interface

 

TE VELTHUIS, AREND JAN

 

PRINCETON UNIVERSITY

 

Structure and Dynamics of RNA Elements Regulating Viral Aberrant RNA Synthesis

 

THYME, SUMMER B

 

UNIVERSITY OF ALABAMA AT BIRMINGHAM

 

Defining the Chemical Perturbome of Neural Development and Activity

 

UHLER, CAROLINE

 

BROAD INSTITUTE, INC.

 

Causal Representation Learning for the Spatial Analysis of Transcriptomic and Imaging Data in Tissue Contexts

 

VAN VALEN, DAVID A

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Unraveling the Genetic Basis of Cellular Behaviors with Deep Learning and Imaging-Based Reverse Genetics

 

WANG, CHAO

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Integrated Nano-Opto-Fluidic System on Sapphire Towards Single-Molecule Protein Sequencing

 

WANG, SIHONG

 

UNIVERSITY OF CHICAGO

 

Immunocompatible Electronic Polymers and Devices for Implantable Sensors and Stimulators that Resist Foreign-Body Responses

 

WANG, WENJING

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

New Classes of Optogenetic and Chemogenetic Tools with a Feedback Control

 

WEEKS, AMY M

 

UNIVERSITY OF WISCONSIN-MADISON

 

Post-Translational Modification Proteomics in 4D: Chemoenzymatic Tools to Map the Dynamic Spatial Organization of Eukaryotic Signaling Pathways

 

WHITELEY, AARON THOMAS

 

UNIVERSITY OF COLORADO

 

Deciphering the Crosstalk Between Bacteria and Their Mammalian Hosts

 

YOUNG, AARON JOHN

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

A New Framework for Self-Adaptive Artificial Intelligence to Personalize Assistance for Patients Using Robotic Exoskeletons and Prostheses

 

 

2021 NIH Director's New Innovator Award (DP2) - RFA-RM-20-012

*Diversity Statement

PI Name Institution Name Title
ABDELFATTAH, AHMED

 

BROWN UNIVERSITY

 

Lighting Up the Brain: Optogenetic Tools to Record, Trace, and Manipulate Brain Circuits at Cellular Resolution

 

ABU-REMAILEH, MONTHER

 

STANFORD UNIVERSITY

 

Innovations and Mechanisms in Tumor Subcellular Metabolism

 

AHARONI, DANIEL

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Developing Long-Term Neuro-Behavioral Recording and Real-Time Processing Platforms for Naturally Behaving Animals

 

ALHADEFF, AMBER L

 

MONELL CHEMICAL SENSES CENTER

 

Harnessing Sensory Food Circuits to Influence Feeding Behavior

 

BACKUS, KERIANN MARIE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

A Systems-Level Approach to Decipher the Protein Interactome

 

BLOSNICH, JOHN RUDOLPH

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Shifting Suicide Prevention Paradigms: Looking Beyond Clinical Settings

 

BRIGIDI, GIAN-STEFANO

 

UNIVERSITY OF UTAH

 

Decoding Neuronal Activity History at the Genome Through the Spatially Segregated Inducible Transcription Factors

 

BROWN, BREANN

 

VANDERBILT UNIVERSITY

 

Off the Beaten Path(Way): Spatiotemporal Investigation of Protein Assemblies Controlling Mitochondrial Metabolism

 

CANZIO, DANIELE

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

How Do Neurons Recognize Self from Non-Self?

 

CAO, JUNYUE

 

ROCKEFELLER UNIVERSITY

 

Single Cell Dynamics on a Whole Organism Scale

 

CHOI, PETER S

 

CHILDREN'S HOSP OF PHILADELPHIA

 

Exploring Hidden Determinants of Splicing with Genome-Targeted Proximity Labeling

 

ENGLISH, JUSTIN G

 

UNIVERSITY OF UTAH

 

Directed Evolution of Cell-Type Specific On-Demand Signaling Control Systems

 

FILBIN, MARIELLA GRUBER

 

DANA-FARBER CANCER INST

 

How the 3D Architecture of the Brain Shapes Cancer Cell Fate Decisions

 

FLEISCHER, CANDACE C

 

EMORY UNIVERSITY

 

A Novel Framework for Quantifying Metabolic Brain Health

 

GOMES, ANA

 

H. LEE MOFFITT CANCER CTR & RES INST

 

Aging as a Selective Pressure that Drives Tumor Progression

 

GONG, YI-NAN

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Necrotic Survivors and Plasma Membrane Integrity Signaling

 

GORODETSKY, ALON A

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Cephalopod-Inspired Bioelectronic Control of Cellular Signaling

 

HEYS, JAMES GERARD

 

UNIVERSITY OF UTAH

 

Uncovering the Neural Circuit and Synaptic Mechanisms Underlying Interval Timing

 

HOSSEINZADEH, PARISA

 

UNIVERSITY OF OREGON

 

A Data-Driven Approach Towards Generation of Permeable Peptide Therapeutics

 

HU, CHI-KUO

 

STATE UNIVERSITY NEW YORK STONY BROOK

 

Understanding Diapause and Its Ability to Suspend and Preserve Life

 

JACKSON, RUAIDHRI

 

HARVARD MEDICAL SCHOOL

 

Illuminating the Immune Systems Genomic Dark Matter: Functionally Annotating the Hidden Translatome

 

KASOWSKI, MAYA

 

STANFORD UNIVERSITY

 

A Single Cell Pooling Framework for Deciphering the Regulatory Wiring of Allergy in Pathophysiologic Contexts

 

KEMALADEWI, DWI UTAMI

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Implications of Genetic Diversity in Muscular Dystrophy

 

KORB, ERICA MEGAN

 

UNIVERSITY OF PENNSYLVANIA

 

The Epigenetic Encoding of Learning and Memory

 

KRANZUSCH, PHILIP J

 

DANA-FARBER CANCER INST

 

Discovery of cGAS-Like Signaling Enzymes in Innate Immunity and Disease

 

KRASILEVA, KSENIA V

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Cross-Kingdom Health: Evolution of Innate Immune Receptors and Their Targets

 

LAIDLAW, BRIAN

 

WASHINGTON UNIVERSITY

 

Enhancing the Antiviral Memory B Cell Response

 

LEE, JOHN KYUNG

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Uncovering Diverse Genotype-Phenotype Relationships in Prostate Cancer

 

LI, GUANG

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Generation of Four-Chambered Hearts Through Organoid Fusions

 

LI, PULIN

 

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

 

Systematic Reconstruction of Epithelial-Mesenchymal Communication in Organ Development

 

MADIGAN, CRESSIDA ARIANNA

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Bacterial Disruption of Neuroimmune Pathways in a Transparent Brain

 

MAJZNER, ROBBIE G

 

STANFORD UNIVERSITY

 

Hijacking the T Cell Machinery for Logic-Gated CAR T Cell Control

 

MIHAYLOVA, MARIA M

 

OHIO STATE UNIVERSITY

 

Determining Age-Dependent Metabolic Changes in Tumors and Their Microenvironment

 

MIR, MUSTAFA AIZED HASAN

 

CHILDREN'S HOSP OF PHILADELPHIA

 

Quantifying the Dynamics of Gene Regulation and Nuclear Organization During Embryogenesis

 

MOK, WENDY W K

 

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

 

Mapping Polymicrobial Interactions that Modulate Antibiotic Persistence

 

MURTHY, SWETHA

 

OREGON HEALTH & SCIENCE UNIVERSITY

 

A New Approach to Study Mechanically Activated Ion Channels

 

NEAL, JAMES THOMAS

 

BROAD INSTITUTE, INC.

 

Optical Functional Genomics

 

ORVEDAHL, ANTHONY W

 

WASHINGTON UNIVERSITY

 

Alveolus as Incubator: Functional Genomic Dissection of the Host Response to SARS-CoV-2 Infection.

 

OUDIN, MADELEINE JULIE

 

TUFTS UNIVERSITY MEDFORD

 

Defining and Exploiting the Neuronal Identity of Cancers

 

PANDARINATH, CHETHAN

 

EMORY UNIVERSITY

 

Fusing Motor Neuroscience and Artificial Intelligence to Create Next-Generation Neural Prostheses

 

PERRY, JUSTIN S

 

SLOAN-KETTERING INST CAN RESEARCH

 

Rethinking the "Quiet" Nature of Apoptotic Cell Clearance

 

PLESA, CALIN

 

UNIVERSITY OF OREGON

 

Proteome Scale Multiplexed Generation of Recombinant Antibodies

 

QUON, GERALD

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

Linking Genetics to Cellular Behavior and Disease Via Multimodal Data Integration

 

RAMANI, VIJAY

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Single-Cell Chemical Transcriptomic Dissection of an Essential Transcription Factor Network

 

RITCHWOOD, TIARNEY D

 

DUKE UNIVERSITY

 

Community-Academic Partnerships to Address COVID-19 Inequities Within African American Communities

 

SAELICES GOMEZ, LORENA

 

UT SOUTHWESTERN MEDICAL CENTER

 

Closing the Gap Between Structural Biology and Translational Science for Amyloid Diseases

 

SHARMA, NIKHIL

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

The Cellular and Molecular Mechanisms Underlying Nociception and Pain

 

SIMUNOVIC, MIJO

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Synthetic Organogenesis: New Paradigms in Reconstituting Human Organ Development In Vitro

 

SMITH, CLARE MARGARET

 

DUKE UNIVERSITY

 

Dissecting the Genetic Basis of Protective Immunity to Tuberculosis in Diverse Hosts

 

SMITH, ZACHARY DYLAN

 

YALE UNIVERSITY

 

Epigenetic and Environmental Impact on Early Embryonic Development

 

SUN, BRYAN

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Insights to Noncoding Disease Variants Using Mosaic Diseases

 

SUN, LU

 

UT SOUTHWESTERN MEDICAL CENTER

 

Molecular and Genetic Decoding of Neuron-Glial Interactions

 

VOS, SEYCHELLE MONQIUE

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Towards Fully Reconstituting Mammalian Transcription in a Test Tube

 

WAGNER, DANIEL E

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Mapping Cell Fate Flow and Feedback Control on Vertebrate Embryonic Landscapes

 

WAN, LILING

 

UNIVERSITY OF PENNSYLVANIA

 

Illuminating Transcriptional Condensates Using an Integrated Approach

 

WAN, WILLIAM N

 

VANDERBILT UNIVERSITY

 

Elucidating the Mechanisms of Viral Life Cycles Under Near-Native Conditions

 

WANG, XIAO

 

BROAD INSTITUTE, INC.

 

Single-Cell In Situ Analysis of RNA Modifications in Intact Tissues

 

WEAVER, JESSICA DIANE

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Immunosuppression-Free Transplantation Through Placental Mimicry

 

WENDLANDT, ALISON

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Late Stage Stereochemical Editing to Transform the Synthesis of Bioactive Molecules

 

WONG, YVETTE

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

The Dynamic Architecture of Living Cells: Uncovering Intra-Organelle Events at Nanoscale Levels

 

WU, NICHOLAS C

 

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

 

High-Throughput Identification of Antibody Features for Sequence-Based Epitope Prediction

 

YAN, JING

 

YALE UNIVERSITY

 

Tracking Single-Cell Gene Expression Heterogeneity and Its Consequences in Bacterial Biofilms

 

ZHAO, SHUANG

 

UNIVERSITY OF WISCONSIN-MADISON

 

Dynamic Molecular Evoluation of Treatment Resistant Cancer

 

ZHOU, JIAN

 

UT SOUTHWESTERN MEDICAL CENTER

 

Sequence Models of Genome Regulatory Architecture in 3D

 

2020 NIH Director's New Innovator Award (DP2) - RFA-RM-19-006

*Diversity Statement

PI Name Institution Name Title
ACOSTA, VICTOR MARCEL

 

UNIVERSITY OF NEW MEXICO

 

Nuclear Magnetic Resonance Microscope Based on Diamond Quantum Sensors

 

ALLEN, ALICIA M

 

UNIVERSITY OF ARIZONA

 

Hormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle During the Postpartum Period

 

ANWAR, MEKHAIL

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Implantable Nanophotonic Sensors for In Vivo Immunoresponse

 

ARONOV, DMITRIY

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Using a Specialized Behavior to Study the Neural Mechanisms of Episodic Memory

 

BAO, HUAN

 

SCRIPPS FLORIDA

 

Developing Next-Generation Nanodiscs for the Study and Modulation of Membrane Proteins

 

BASU, ANINDITA

 

UNIVERSITY OF CHICAGO

 

Profiling Transcriptional Heterogeneity in Microbial Cells at Single Cell Resolution and High-Throughput Using Droplet Microfluidics

 

BIRNBAUM, MICHAEL

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Repertoire-Scale T Cell Antigen Identification Via Peptide-Mhc Lentivirus Display

 

CONSTANTINOPLE, CHRISTINE MARIE

 

NEW YORK UNIVERSITY

 

Neural Circuit Mechanisms of Arithmetic for Economic Decision-Making

 

CORDER, GREGORY

 

UNIVERSITY OF PENNSYLVANIA

 

Harnessing Cortical Neuromodulation to Disrupt Pain Perception

 

DASGUPTA, SUBHAMOY

 

ROSWELL PARK CANCER INSTITUTE CORP

 

Decoding the Nuclear Metabolic Processes Regulating Gene Transcription

 

DEMAZUMDER, DEEPTANKAR

 

UNIVERSITY OF CINCINNATI

 

Eavesdropping on Heart-Brain Conversations During Sleep for Early Detection and Prevention of Fatal Cardiovascular Disease

 

FALKNER, ANNEGRET LEA

 

PRINCETON UNIVERSITY

 

Generating Pro-Resilient States Through Individualized Circuit Read-Write Therapeutics

 

FONT-BURGADA, JOAN

 

RESEARCH INST OF FOX CHASE CAN CTR

 

New Tools for Understanding Metastasis Through Tissue Resident Cells: Enabling an Extensive Medicine Strategy for Metastatic Disease

 

FRIED, STEPHEN DAVID

 

JOHNS HOPKINS UNIVERSITY

 

Watching Proteins Fold (or Misfold) In Vivo with Mass Spectrometry

 

GUO, FENG

 

INDIANA UNIVERSITY BLOOMINGTON

 

An Acoustofluidic Avidity Cytometer for Massive Parallel Profiling Single Autoreactive T Cell in Autoimmune Disease

 

HAI, AVIAD

 

UNIVERSITY OF WISCONSIN-MADISON

 

Achieving Direct Functional Imaging of Brain Electrophysiology: Nanofabricated Cell-Sized Electronic Sensors for Magnetic Resonance Imaging

 

HANSEN, ANDERS SEJR

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Dynamic Bottom-Up Dissection of Chromatin Looping and Gene Regulation

 

HAROUSH, KEREN

 

STANFORD UNIVERSITY

 

Unraveling Neuronal Circuits and Causal Underpinnings of Long Time-Scale Social Strategic Behaviors

 

HEKSTRA, DOEKE ROMKE

 

HARVARD UNIVERSITY

 

Identifying Principles of Protein Mechanics by Applying Force and Observing Motion

 

HULTMAN, RAINBO

 

UNIVERSITY OF IOWA

 

Electrical Connectomics: An Innovative Approach for Dissecting Brain Mechanisms Underlying Behavioral States

 

JAISWAL, SIDDHARTHA

 

STANFORD UNIVERSITY

 

Clonal Hematopoiesis in Human Aging and Disease

 

KAO, JONATHAN CHAU-YAN

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Next Generation Brain-Machine Interfaces Controlled Synergistically with Artificial Intelligence

 

KIM, SUNG SOO

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Neural Circuit Mechanisms Underlying Dynamic Stimulus Selection

 

KUZUM, DUYGU

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

E-Organoids: Functional Brain Organoids Co-Grafted with Transparent Microthreads

 

LARIMER, BENJAMIN M

 

UNIVERSITY OF ALABAMA AT BIRMINGHAM

 

Site-Specific Immune Cell Activation Detection for Improving Individualized Cancer Immunotherapy

 

LEE, EUNJUNG ALICE

 

BOSTON CHILDREN'S HOSPITAL

 

Mechanism for Endogenous Retroelements to Mimic Ancient Exogenous Identities in Aging and Diseased Human Tissue

 

LI, YANRAN

 

UNIVERSITY OF CALIFORNIA RIVERSIDE

 

Reprogramming Plant Perception for Novel Plant Natural Products Discovery

 

LIEBERMAN, TAMI D

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

An Evolutionary Framework for Identifying Determinants of Colonization in Human Microbiomes

 

LONGDEN, THOMAS A

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Vascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and Disease

 

MILLER, MILES A

 

MASSACHUSETTS GENERAL HOSPITAL

 

Dissection of In Situ Myeloid Signaling Using Image-Guided Synthetic Control

 

MIRI, JOSEPH ANDREW

 

NORTHWESTERN UNIVERSITY

 

Combining Physiological, Genetic, and Computational Approaches with Naturalistic Climbing Behavior to Elucidate the Functional Elements of Descending Motor Control

 

MIRZADEH, ZAMAN

 

ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

 

Hypothalamic Neurocircuit Remodeling to Treat Diabetes

 

NAIK, SHRUTI

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Decoding Microbe-Epithelial Stem Cell Interactions in Health and Disease

 

NORMAN, THOMAS MAXWELL

 

SLOAN-KETTERING INST CAN RESEARCH

 

Predictive Engineering of Cellular Transcriptional State

 

PAREDES, MERCEDES

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Gyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic Interventions

 

RACKI, LISA R

 

SCRIPPS RESEARCH INSTITUTE

 

Using Phage to Interrogate Bacterial Heterochromatin

 

ROCKLIN, GABRIEL JACOB

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

High-Throughput Discovery of Protein Energy Landscapes in Natural and Designed Proteomes

 

ROHNER, NICOLAS

 

STOWERS INSTITUTE FOR MEDICAL RESEARCH

 

Starvation Resistance and Resilience of Metabolic Dysfunction in Cavefish

 

SANCAK, YASEMIN S

 

UNIVERSITY OF WASHINGTON

 

Molecular Dissection of Mitochondria-Organelle Interactions

 

SCHMIDT, JENS CHRISTOPHER

 

MICHIGAN STATE UNIVERSITY

 

Single-Molecule Analysis of the DNA Damage Response in Living Cells

 

SHANECHI, MARYAM

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

A Novel Geometric Paradigm for Nonlinear Modeling and Control of Neural Dynamics

 

SHIPMAN, SETH LAWLER

 

J. DAVID GLADSTONE INSTITUTES

 

Engineered Mitochondria for Therapeutic Donation and Mitochondrial Genome Editing

 

SPEER, COLENSO MCNAUGHTON

 

UNIV OF MARYLAND, COLLEGE PARK

 

A Molecular Connectomics Platform for Multi-Scale Analysis of Activity-Dependent Synapse Development and Plasticity

 

STERNBERG, SAMUEL HENRY

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Leveraging Programmable Integrases for Human Genome Engineering

 

STITES, EDWARD C

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Systems Approaches for Opening Therapeutic Windows

 

TAKEBE, TAKANORI

 

CINCINNATI CHILDRENS HOSP MED CTR

 

Engineering Multi-Organs in a Dish

 

WANG, KAIHANG

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Megabase Scale Genome Engineering and Synthesis in Mammalian Cells

 

WEI, LU

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Super-Resolution Chemical Imaging for Biomedicine

 

WHITE, KATHARINE ALICE

 

UNIVERSITY OF NOTRE DAME

 

Roles for Increased Intracellular pH and Heterogeneity in Cancer

 

WU, XUEBING

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Genome-Wide Studies of the Noncoding Functions and Mechanisms of Human mRNAs

 

YAN, KELLEY

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Directing Cell Fate Along the Intestinal Enteroendocrine Lineage

 

YE, LI

 

SCRIPPS RESEARCH INSTITUTE

 

Modulating Somatosensory Network to Target Metabolic Diseases

 

ZHU, BOKAI

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Decoding The Regulation and Functions of Mammalian 12h-Clock

 

 

2019 NIH Director's New Innovator Award (DP2) - RFA-RM-18-008

*Advisory Committee to the NIH Director Working Group Findings

PI Name Institution Name Title
AKBARI, OMAR SULTAN

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Development of Synthetic Viral Circuitry to Regulate Viruses in Mosquito Disease Vectors

 

BEIER, KEVIN T

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Sculpting the Brain: High-Resolution Spatiotemporally-Controlled Modulation of Memories

 

BEYDER, ARTHUR

 

MAYO CLINIC ROCHESTER

 

Does the Gut Have a Sense of Touch?

 

BOHORQUEZ, DIEGO V

 

DUKE UNIVERSITY

 

Reversing Autism Linked Behaviors from the Gut

 

BUENROSTRO, JASON DANIEL

 

HARVARD UNIVERSITY

 

Single-Cell Epigenomic and Cellular Plasticity

 

BULLER, ANDREW

 

UNIVERSITY OF WISCONSIN-MADISON

 

Engineering In Vivo Biomolecular Synthesis with Non-Standard Building Blocks

 

CAI, DENISE JADE

 

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

 

How Does the Brain Maximize Storage Capacity?

 

CARMONA-FONTAINE, CARLOS

 

NEW YORK UNIVERSITY

 

Decoding the Fundamental Mechanisms of Tumor Emergence and Evolution

 

CARVUNIS, ANNE-RUXANDRA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

From Non-Coding to Coding: Uncovering the Hidden Coding Potential of Non-Coding Sequences and Its Role in De Novo Gene Evolution

 

CHANG, RUI

 

YALE UNIVERSITY

 

Understand the Little Brain on the Heart: A Molecular and Functional Dissection of the Intrinsic Cardiac Nervous System

 

DAYEH, SHADI

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Bringing Light to Functional Mapping in Resective Neurosurgery

 

DEANS, TARA LYNN

 

UNIVERSITY OF UTAH

 

Engineered Platelets for the Targeted Destruction of Circulating Tumor Cells

 

DIONNE, JENNIFER A

 

STANFORD UNIVERSITY

 

Nano-Optical Reporters of Dynamic Mechanotransduction in the Immune System

 

DOWNING, TIMOTHY LAMONT

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Spatial Epigenomics: A New Framework for Overcoming Mechanical Heterogeneity in Solid Tumors

 

DUPAGE, MICHEL

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Engineering Precision Cancer Immunotherapy

 

EDLOW, BRIAN L

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness After Traumatic Coma

 

FATTAHI, FARANAK

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Modeling Neurodegenerative Disease Manifestations in Human Enteric Neurons

 

GREER, PAUL LIEBERMAN

 

UNIV OF MASSACHUSETTS MED SCH WORCESTER

 

Elucidating the Role of a Novel Family of Chemoreceptor in Alzheimers Disease

 

GUO, CHUN-JUN

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

An Integrative and Generalizable Approach to Modulate Microbiota Small Molecules in the Host

 

GUPTA, RAJAT M

 

BRIGHAM AND WOMEN'S HOSPITAL

 

A Genetic Approach to Identify the Common Mechanisms of Vascular Disease

 

KLOXIN, APRIL M

 

UNIVERSITY OF DELAWARE

 

Unraveling Fibrosis with Dynamic Microenvironments and Molecular Tools

 

KOCHER, SARAH D

 

PRINCETON UNIVERSITY

 

What Makes - and Breaks - a Social Brain?

 

LEGANT, WESLEY R

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Connecting the Dots Between Single Molecule Dynamics and Cell Differentiation

 

LEIFER, ANDREW MICHAEL

 

PRINCETON UNIVERSITY

 

Probing Brain-Wide Functional Connectivity During Behavior

 

LERNER, TALIA NEWCOMBE

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

How Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric Disease

 

LEVY, MAAYAN

 

UNIVERSITY OF PENNSYLVANIA

 

Post-Biotic Interventions to Ameliorate Age-Related Inflammation

 

LI, HAN

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Engineering an Unnatural Redox Cofactor (Uredox) System for Efficient Biosynthesis of Medicines

 

LIAU, BRIAN

 

HARVARD UNIVERSITY

 

Mapping Structure-Activity Relationships of Chemical Inhibitors Via Genome-Editing

 

LUEDTKE, ALEX

 

UNIVERSITY OF WASHINGTON

 

High-Resolution Inference for Correlates of Vaccine Protection

 

MCCORMICK, TYLER

 

UNIVERSITY OF WASHINGTON

 

Big Data, Big Models, and Big Bias?: A Decision Making Framework for Vital Rate Estimates Based on Extrapolation

 

MOHIMANI, HOSEIN

 

CARNEGIE-MELLON UNIVERSITY

 

Discovering Novel Small Molecule Antibiotics from Complex Microbial Communities by Integrating Computational Mass Spectrometry and Metagenome Mining

 

MORIZANE, RYUJI

 

MASSACHUSETTS GENERAL HOSPITAL

 

Recreating Kidney Organogenesis In Vitro with Human Pluripotent Stem Cells

 

MUZUMDAR, MANDAR DEEPAK

 

YALE UNIVERSITY

 

Defining Tumor Cell and Host Adaptations in Cancer Progression

 

NIU, JIA

 

BOSTON COLLEGE

 

Development of Compact CRISPR Editors for Multiplexed Editing of Complex Gene Networks

 

O'CONNELL, LAUREN A

 

STANFORD UNIVERSITY

 

Dietary Tuning of Infant Social Communication

 

OLABISI, OPEYEMI AYODEJI

 

DUKE UNIVERSITY

 

A Human Stem Cell-Derived Podocyte Model for APOL1 Nephropathy

 

PALM, NOAH WOLCOTT

 

YALE UNIVERSITY

 

A Forward Chemical Genetic Screen to Illuminate the Dark Matter of the Bioactive Microbiota Metabolome

 

PERANTEAU, WILLIAM H

 

CHILDREN'S HOSP OF PHILADELPHIA

 

In Utero CRISPR-Mediated Gene Editing to Cure Congenital Monogenic Disorders

 

POLLEN, ALEXANDER A

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Establishing a Stem Cell Biology Platform for Decoding the Genetic Basis of Human Brain Specializations

 

POULOPOULOS, ALEXANDROS

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Untangling the Biology of Brain Wiring: High-Throughput Innovations for Molecular Screening and Functional Targeting of Circuit Development In Vivo

 

PUA, HEATHER H

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Extracellular RNA Communication in Lung Inflammation

 

RAKOFF-NAHOUM, SETH

 

BOSTON CHILDREN'S HOSPITAL

 

Positive Selection as a Host Mechanism to Control the Microbiome

 

RUNYAN, CAROLINE ANNE

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Communication Between Networks: Context, Inhibition, and Neuromodulation

 

SCHUG, ZACHARY

 

WISTAR INSTITUTE

 

The Multifaceted Role of Acetate in Cancer

 

SCHWARZ, LINDSAY A

 

ST. JUDE CHILDREN'S RESEARCH HOSPITAL

 

Intersectional Strategies to Understand the Function of Diverse Neural Circuits

 

SHALEM, OPHIR

 

CHILDREN'S HOSP OF PHILADELPHIA

 

Direct and Rapid Control of Proteins at Scale

 

SHAO, SICHEN

 

HARVARD MEDICAL SCHOOL

 

Decoding Ribosome-Triggered Quality Control Mechanisms

 

SHARMA, UPASNA

 

UNIVERSITY OF CALIFORNIA SANTA CRUZ

 

Paternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance Via Sperm Small RNAs

 

SIMOES-COSTA, MARCOS

 

CORNELL UNIVERSITY

 

Spatial Control of Pattern Formation in Early Vertebrate Development

 

SMITH, CODY J

 

UNIVERSITY OF NOTRE DAME

 

An Integrative Approach to Elucidate Glial Diversity and Its Role in Brain Functionality

 

TAGLIABRACCI, VINCENT SCOTT

 

UT SOUTHWESTERN MEDICAL CENTER

 

Breathing Life into Dead Enzymes

 

THAISS, CHRISTOPH ALEXANDER

 

UNIVERSITY OF PENNSYLVANIA

 

A Conserved Function of Amyloid Proteins in Host-Microbiome Interactions

 

THEUNISSEN, THOROLD

 

WASHINGTON UNIVERSITY

 

Resolving Epigenetic Instability During Pluripotent State Transitions: A Roadmap for Exploiting the Biomedical Potential of Dynamic Human Stem Cell States

 

VEDANTHAM, VASANTH

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

A Regenerative Approach to Cardiac Pacing

 

VILLANI, ALEXANDRA-CHLOE

 

MASSACHUSETTS GENERAL HOSPITAL

 

Deciphering the Achilles Heel of Cancer Immunotherapy

 

VOORHEES, REBECCA MARIA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Protein Complex Assembly in the ER Membrane

 

WANG, SIYUAN

 

YALE UNIVERSITY

 

Building the 3D Genomic Regulatome

 

WON, HYEJUNG

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Deciphering Cell-Type Specific Regulatory Landscape in Human Brain

 

YUEN, COURTNEY MINGMEN

 

BRIGHAM AND WOMEN'S HOSPITAL

 

New Approaches to Optimizing the Application and Measuring the Impact of Community-Based Tuberculosis Interventions

 

ZHANG, XIAOCHANG

 

UNIVERSITY OF CHICAGO

 

Single Cell Detection of Dynamic Protein-RNA Interaction

 

 

2018 NIH Director's New Innovator Award (DP2) - RFA-RM-17-006

*Commitment to Diversity

PI Name Institution Name Title
BOETTIGER, ALISTAIR

 

STANFORD UNIVERSITY

 

High Resolution Imaging of Genome Structure and Gene Regulation in Development

 

CARVILL, GEMMA LOUISE

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

Cell-Free DNA Sequencing Approaches to Define the Genetic Etiology of Unexplained Epilepsy

 

CHEN, JERRY L

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

Cracking Genetically Defined Neocortical Circuits across Learning and Behavior

 

CHEN, SIDI

 

YALE UNIVERSITY

 

High-Throughput In Vivo Genetics for Immunotherapy Target Discovery

 

CHEVRIER, NICOLAS

 

UNIVERSITY OF CHICAGO

 

Building a Predictive Framework for Adjuvant Combinatorics in Vaccine Development

 

CHUNG, EUN JI

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

A Revolutionary Approach for Polycystic Kidney Disease: Oral Nanotherapeutics

 

DENNIS, MEGAN Y

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

The Function of Duplicated Genes in Human Brain Evolution and Disease

 

DONALDSON, ZOE REBECCA

 

UNIVERSITY OF COLORADO

 

Neuronal Basis of Social Motivation and the Failure to Adapt to Loss

 

DOULATOV, SERGEI

 

UNIVERSITY OF WASHINGTON

 

Uncovering Epigenetic Barriers to Hematopoietic Stem Cell Formation

 

DUTTON, RACHEL J

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Molecular Mechanisms that Shape Microbial Communities

 

EHRLICH, KATHERINE BABCOCK

 

UNIVERSITY OF GEORGIA

 

Innovative Approaches to the Study of Social Determinants of Health in Children

 

FEINBERG, EVAN HARRIMAN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

High-Resolution Neural Circuit Dissection with Controllers Locally Affecting Synaptic Partners (CLASP)

 

FLOOR, STEPHEN NICHOLAS

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

The Impact of Human RNA Diversity on Protein Production and Cell Fate

 

FREDERICK, KENDRA KING

 

UT SOUTHWESTERN MEDICAL CENTER

 

High Sensitivity NMR for Structure Determination of Neurodegenerative Disease Associated Protein Aggregates in Native Contexts

 

GALLEGO-PEREZ, DANIEL

 

OHIO STATE UNIVERSITY

 

Novel Nanoscale Approaches to Whole Tissue Reprogramming

 

GAWAD, CHARLES

 

ST. JUDE CHILDREN'S RESEARCH HOSPITAL

 

Creating a Catalog of Cancer Clonotype Drug Sensitivities with Single-Cell Genome Sequencing

 

GILBERT, LUKE

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

A Genetic Interaction Map of the Human Nucleus

 

GONG, YIYANG

 

DUKE UNIVERSITY

 

Voltage Imaging Dissection of the Mammalian Cortex

 

GORDON, REYNA LEIGH

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Biomarkers of Rhythmic Communication: Integrating Foundational and Translational Approaches

 

GUO, JUNJIE

 

YALE UNIVERSITY

 

Molecular and Cellular Determinants of RNA Repeat-Associated Properties

 

HARIADI, RIZAL FAJAR

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Nanoscale Reconstruction of Mechanical Systems Involved in Disease Pathogenesis

 

HUANG, JUN

 

UNIVERSITY OF CHICAGO

 

Molecular Mechanism of Natural Killer Cell Recognition

 

JAIN, RAJAN

 

UNIVERSITY OF PENNSYLVANIA

 

Deciphering Nuclear Lamina-Chromatin Organization in Cellular Competence and Cardiac Development

 

KAYSER, MATTHEW S

 

UNIVERSITY OF PENNSYLVANIA

 

Building Brains in Our Sleep: A Drosophila Larval Platform for Examining Sleep and Neurogenesis

 

KIM, JUSTIN

 

DANA-FARBER CANCER INST

 

Post-Translational Modification of Protein Surfaces

 

KING, KEVIN R

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Elucidating Cell Communication Networks During Tissue Inflammation, Fibrosis, and Regeneration

 

KWON, ESTER J

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Nanoscale Biomaterials for Targeted Repair in Traumatic Brain Injury

 

LANDAU, DAN

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution

 

LIU, SHIXIN

 

ROCKEFELLER UNIVERSITY

 

Probing Symmetry Breaking in Epigenetic Inheritance: From Single Molecules to Systems Biology

 

LOH, PO-RU

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Revealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic Structural Variants

 

MCBRIDE, CAROLYN SARAH

 

PRINCETON UNIVERSITY

 

Mapping the Combinatorial Olfactory Inputs that Drive Mosquito Host Attraction

 

MISHRA, PRASHANT

 

UT SOUTHWESTERN MEDICAL CENTER

 

Engineering Faithful Animal Models of Mitochondrial Disease

 

MITCHELL, MICHAEL J

 

UNIVERSITY OF PENNSYLVANIA

 

A Data-Driven Drug Delivery (4D) Platform for Probing and Treating the Chemoresistant Bone Marrow Microenvironment

 

MOORE, DARCIE LEANN

 

UNIVERSITY OF WISCONSIN-MADISON

 

The Mechanisms and Functional Role of the Asymmetric Segregation of Cellular Cargoes in Stem Cells

 

PATHAK, MEDHA M

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Building the Brain: How Mechanical Forces Shape Human Neural Development

 

RAMAN, SRIVATSAN

 

UNIVERSITY OF WISCONSIN-MADISON

 

Understanding Molecular Rules Governing Protein Allostery by Deep Mutational Scanning

 

ROCK, JEREMY MICHAEL

 

ROCKEFELLER UNIVERSITY

 

Towards a Molecular Understanding of Persistent Tuberculosis Infection

 

ROYBAL, KOLE T

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Engineering the Next-generation of Custom Immune Cell Therapies

 

RUDER, WARREN CHRISTOPHER

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Creating Magnetically Inducible Synthetic Gene Networks for Cell and Tissue Therapies

 

SAFDAR, NASIA

 

UNIVERSITY OF WISCONSIN-MADISON

 

Modelling Applications and Systems Engineering to Reduce Infections the MASTERI Study

 

SAGGAR, MANISH

 

STANFORD UNIVERSITY

 

Only Time Will Tell: A Computational Psychiatry Approach to Model Temporal Transitions in Brain Activity as a Lens Towards Developing Better Diagnostic Nosology for Psychiatric Illness

 

SCHARSCHMIDT, TIFFANY CRAWFORD

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Decoding and Harnessing Microbial Tuning of T Cell Responses in Early Life

 

SHEFFIELD, MARK E J

 

UNIVERSITY OF CHICAGO

 

Sub-Cellular Resolution Functional Imaging and Optogenetic Manipulation of Identified Memory Circuits During Behavior

 

SLETTEN, ELLEN MAY

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Bioorthogonal Host-Guest Chemistry for Tandem Imaging and Therapy

 

SPENCER, SABRINA LEIGH

 

UNIVERSITY OF COLORADO

 

Proliferation-Quiescence Control in Single Cells: Integration of Mitogen, Nutrient, and Stress Signaling

 

STEPHANOPOULOS, NICHOLAS

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Chemical Synthesis of G Protein-Coupled Receptors Using Sequential DNA-Templated Reactions

 

TADROSS, MICHAEL R

 

DUKE UNIVERSITY

 

Interrogating Dynamics of Whole-Brain Volumes with Cell Type-Specific Pharmacology

 

TITOV, DENIS VASILIEVICH

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Genetically Encoded Tools for Manipulation of Metabolism In Vivo

 

TOMER, RAJU

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

A Comparative Approach for Decomposing the Mammalian Brain Architectural Complexity

 

VARGAS-IRWIN, CARLOS

 

BROWN UNIVERSITY

 

Synergistic Effector/Environment Encoding: A New Perspective on Motor Cortex and Brain-Computer Interfaces

 

WATANABE, SHIGEKI

 

JOHNS HOPKINS UNIVERSITY

 

Reviving Electron Microscopy for Synaptic Cell Biology

 

WESOLOWSKI, AMY

 

JOHNS HOPKINS UNIVERSITY

 

Disease Emergence and Elimination: Using Mobility Data to Inform Spatial Disease Dynamics

 

WHITEHEAD, KATHRYN A

 

CARNEGIE-MELLON UNIVERSITY

 

Fate, Function and Genetic Engineering of Breast Milk Cells for Infant Therapy

 

WRIGHT, ERIK SCOTT

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Uncovering Synergistic Antibiotic Cocktails with Comparative Genomics

 

XU, KE

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Intracellular Phase Separation at the Nanoscale: A Functional Super-Resolution Approach

 

YAMANAKA, NAOKI

 

UNIVERSITY OF CALIFORNIA RIVERSIDE

 

Membrane Steroid Hormone Transporters in Development and Reproduction

 

ZANDERS, SARAH ELIZABETH

 

STOWERS INSTITUTE FOR MEDICAL RESEARCH

 

Models of Selfishness: Molecular and Evolutionary Analyses of the Wtf Meiotic Drivers

 

ZHAO, YONGXIN

 

CARNEGIE-MELLON UNIVERSITY

 

Highly Multiplexed Nanoscale Imaging Platforms for Profiling and Interrogation of Complex Diseases

 

 

2017 NIH Director's New Innovator Award (DP2) - RFA-RM-16-004

*Statement on Diversity

PI Name Institution Name Title
AJIJOLA, OLUJIMI A

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Multimodal Decoding of the Neural Circuitry of Sudden Death in Peripheral Ganglia

 

AZIM, EIMAN

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Neural Control of Skilled Movements: An Ethological Dissection of Genetically Tractable Mammalian Motor Circuits

 

BARMAN, ISHAN

 

JOHNS HOPKINS UNIVERSITY

 

Spectroscopy Assisted Mechano-Chemical Phenotype Recognition Nanoscope

 

BIRSOY, KIVANC

 

ROCKEFELLER UNIVERSITY

 

Dissecting Tumor Metabolic Heterogeneity In Vivo

 

BLACKBURN, JESSICA S

 

UNIVERSITY OF KENTUCKY

 

Harnessing Single Cell Technology to Define Self-Renewal in Normal and Malignant Stem Cells

 

BLAINEY, PAUL CLARK

 

BROAD INSTITUTE, INC.

 

Live Cell Transcriptomics

 

BRITO, ILANA LAUREN

 

CORNELL UNIVERSITY

 

Systems-Level Perspectives of Horizontal Gene Transfer Within the Human Microbiome

 

CALVE, SARAH

 

PURDUE UNIVERSITY

 

Defining the Mechanical Link that Unites the Musculoskeletal System During Limb Development

 

CAMBRONNE, XIAOLU ANG

 

OREGON HEALTH & SCIENCE UNIVERSITY

 

Gatekeepers of Mitochondrial NAD+

 

CHEN, ZHILEI

 

TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

 

Artificial Ecology Sink as Prophylaxis Against Viral Infection

 

CHOI, JAEHYUK

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

Identifying Mechanisms Governing T Cell Diversity

 

COLLINS, SEAN RYAN

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

Rewiring Control of Leukocyte Motility for Therapeutic Application

 

CORN, JACOB ELLERY

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Discovering Mechanisms that Regulate Organelle Autophagy

 

DE VLAMINCK, IWIJN

 

CORNELL UNIVERSITY

 

Precision Monitoring of Kidney Transplants Via Single-Cell and Single-Molecule Sequencing

 

DELGOFFE, GREG M

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Exploring and Exploiting Metabolic Plasticity in Regulatory T Cells

 

DERBYSHIRE, EMILY R

 

DUKE UNIVERSITY

 

Enabling Host Processes for Defense Against Liver Stage Malaria Infection

 

ESVELT, KEVIN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Developing Powerful Daisy Drive Systems for the Precise Alteration of Local Populations

 

FARLEY, EMMA KIRSTEN

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Deciphering the Regulatory Principles Governing Enhancer Specificity

 

FEI, JINGYI

 

UNIVERSITY OF CHICAGO

 

Quantitative Imaging of Epitranscriptomic Regulation Mediated by RNA Modification

 

GAHARWAR, AKHILESH K

 

TEXAS ENGINEERING EXPERIMENT STATION

 

Mineralomics: Designing Mineral Based Therapeutics to Control and Direct Cell Function

 

GARCIA, HERNAN GUSTAVO

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Lighting Up the Central Dogma in Embryonic Development

 

GREEN, ALEXANDER ARTHUR

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Molecular Fuses for Real-Time, Label-Free, Multiplexed Imaging of RNAs in Living Cells

 

HIRES, SAMUEL ANDREW

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

New Approaches to Understanding Sensorimotor Learning and Perception

 

HOLLIS, EDMUND R

 

WINIFRED MASTERSON BURKE MED RES INST

 

Modulation of Cortical Networks, a New Approach to Spinal Cord Injury Rehabilitation

 

HON, GARY CHUNG

 

UT SOUTHWESTERN MEDICAL CENTER

 

Combinatorial Biology of Gene Regulation for Cellular Engineering

 

HWANG, SEUNGMIN

 

UNIVERSITY OF CHICAGO

 

Targeting by Autophagy Proteins for Anti-Tumor Immunity

 

IVANOVIC, TIJANA

 

BRANDEIS UNIVERSITY

 

Building Mechanistic Insight into Evolvability of Viral Cell-Entry Functions

 

KIM, YONGTAE

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Probing the Functional Heterogeneity of High-Density Lipoprotein Using Physiological Biomimicry

 

LI, BO

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Mining Genomes for Synergistic Antibiotics

 

LI, LINGYIN

 

STANFORD UNIVERSITY

 

Chemical Biology of Innate Immunity for Treating Cancer and Autoimmunity

 

LINOS, ELENI

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Targeted Advertising for Cancer Prevention

 

MACOSKO, EVAN Z

 

BROAD INSTITUTE, INC.

 

Slide-Seq: High-Resolution In Situ Expression Profiling for Neuropathology

 

MALVANKAR, NIKHIL

 

YALE UNIVERSITY

 

Targeting Bacterial Infections by Imaging Electrical Interactions Between Host Surface Pathogens

 

MOELLERING, RAYMOND E

 

UNIVERSITY OF CHICAGO

 

Targeting Transcription with Synthetic Biologics

 

MOLOFSKY, ANNA V

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Coordinate Regulation of Neural Circuit Remodeling by Glia: A Prospective Molecular Approach

 

MORGAN, DANIEL J

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Incorporating Bayesian Reasoning into Physician Testing and Treatment Decisions

 

OH, JULIA S

 

JACKSON LABORATORY

 

Metagenomes to Therapeutics: Defining the Rules for Engineering the Skin Microbiome

 

PANNIER, ANGELA K

 

UNIVERSITY OF NEBRASKA LINCOLN

 

Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies

 

RAJASETHUPATHY, PRIYA

 

ROCKEFELLER UNIVERSITY

 

Bridging the Gap from Genes to Circuits to Behavior in Understanding Cognitive Dysfunction

 

ROSE, SHERRI

 

HARVARD MEDICAL SCHOOL

 

Machine Learning for Health Outcomes and Quality of Care in Low-Income Populations

 

SAMUEL, BUCK SPARROW

 

BAYLOR COLLEGE OF MEDICINE

 

Microbial Programming of Host Physiology

 

SANJANA, NEVILLE

 

NEW YORK GENOME CENTER

 

In Situ Functional Genomics to UnderstandTranscriptional Regulation

 

SARMA, KAVITHA

 

WISTAR INSTITUTE

 

Epigenetic Regulation Through the Formation and Resolution of R Loops

 

SCHIETINGER, ANDREA

 

SLOAN-KETTERING INST CAN RESEARCH

 

Spatiotemporal Regulation of T Cell Fate Decisions in Cancer

 

SCHLAU-COHEN, GABRIELA

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Nanometer Distance Assay to Uncover Protein Dynamics

 

SHEEHAN, MICHAEL J

 

CORNELL UNIVERSITY

 

Encoding Knowledge in the Genome

 

SIEGRIST, MARY SLOAN

 

UNIVERSITY OF MASSACHUSETTS AMHERST

 

Chemical Detection of Mycobacterium tuberculosis Growth and Antibiotic Response during Infection

 

SLUSKY, JOANNA S

 

UNIVERSITY OF KANSAS LAWRENCE

 

Designed Beta-Strands for Inhibiting Efflux Pumps and Disabling Antibiotic Resistance

 

SUBRAMANIAN, RADHIKA

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Versatile Platform for Reconstructing the Spatial Organization of Intracellular Signaling During Cell-Division

 

TRITSCH, NICOLAS XAVIER

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

A Novel Framework for the Functional Dissection of Motor Systems

 

VON MOLTKE, JAKOB

 

UNIVERSITY OF WASHINGTON

 

Sensing of Helminths by Tuft Cells

 

WAINGER, BRIAN JASON

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Human Stem Cell-Derived Neuromuscular Junction Model for Amyotrophic Lateral Sclerosis

 

WU, HAO

 

UNIVERSITY OF PENNSYLVANIA

 

Charting Oxygen-Sensing Gene Regulatory Network in Cardiomyocytes Through Single-Cell Analysis and Epigenome Editing

 

YANG, HUANGHE

 

DUKE UNIVERSITY

 

Manipulating TMEM16F Lipid Scramblase to Understand the Transbilayer Phospholipid Transport Phenomenon

 

ZHENG, YUEBING

 

UNIVERSITY OF TEXAS AT AUSTIN

 

On-Chip Multiplexed Adhesion Frequency Assay for Measuring Receptor-Ligand Interactions on Cells

 

 

2016 NIH Director's New Innovator Award (DP2) - RFA-RM-13-007

PI Name Institution Name Title
AL-SADY, BASSEM 

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Reconstructing Dynamic Epigenetic Genome Partitioning in Single Stem Cells

 

ANDREWS, JASON RANDOLPH

 

STANFORD UNIVERSITY

 

Congregate Air Sampling for Population-Based Detection of Tuberculosis

 

APOSTOLOU, EFFIE

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Defining the Role of Chromatin Architecture in Cell Fate Inheritance

 

BAUER, DANIEL EVAN

 

CHILDREN'S HOSPITAL CORPORATION

 

High-Throughput Discovery of Essential Noncoding Sequences for Erythropoiesis

 

BENDALL, SEAN CURTIS

 

STANFORD UNIVERSITY

 

Origins of Human Blood Lineages in Regenerative Medicine

 

BHATNAGAR, PARIJAT

 

SRI INTERNATIONAL

 

Self-Assembled Therapeutics with Spatiotemporal Resolution

 

BROHAWN, STEPHEN GRAF

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

New Approaches to Understanding Biological Force Sensation

 

CHEN, IRENE A

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Understanding How Bacteriophages Affect Wound Ecologies and Developing New Tools to Harness Bacteria-Phage Interactions

 

CHIU, ISAAC MING-CHENG

 

HARVARD MEDICAL SCHOOL

 

Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota

 

CHUNG, KWANGHUN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Proteome-Driven Holistic Reconstruction of Organ-Wide Multi-Scale Networks

 

CRAWFORD, FORREST WRENN

 

YALE UNIVERSITY

 

Network-Based Epidemiology for Hidden and Hard-to-Reach Populations

 

CRUM, ALIA

 

STANFORD UNIVERSITY

 

Harnessing Mindset in 21st Century Healthcare

 

DUS, MONICA

 

UNIVERSITY OF MICHIGAN

 

The Role of Neuroepigenetics in Bidirectional Behavioral States

 

EGAN, ELIZABETH S.

 

STANFORD UNIVERSITY

 

Identifying Critical Erythrocyte Host Factors for Plasmodium falciparum Malaria

 

FORDYCE, POLLY MORRELL

 

STANFORD UNIVERSITY

 

Leveraging Spectral Encoding for High Dimensional Biological Multiplexing

 

GREER, ERIC LIEBERMAN

 

CHILDREN'S HOSPITAL CORPORATION

 

Characterization of DNA N6-Methyl Adenine and Its Role in Epigenetic Memory

 

GUO, SHANGQIN

 

YALE UNIVERSITY

 

Molecular Definition of Cancer Cell-of-Origin

 

HAMMOUD, SAHER SUE

 

UNIVERSITY OF MICHIGAN

 

Contributions of Sperm Chromatin to Development: A Myth or Reality?

 

JOKERST, JESSE VINCENT

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Therapeutic Drug Monitoring with a Wearable Ultrasound-Based Sensor

 

KHALIL, AHMAD SAMIR

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

Combatting Antibiotic Resistance with Synthetic Biology Technologies

 

KLINGE, SEBASTIAN

 

ROCKEFELLER UNIVERSITY

 

Trapping and Reconstituting Early Stages of Eukaryotic Ribosome Assembly

 

KOREN, AMNON

 

CORNELL UNIVERSITY

 

Personal Mutational Landscapes Encoded in Our DNA

 

KRALJ, JOEL MARK

 

UNIVERSITY OF COLORADO

 

Neuronal Electromics in Health and Disease

 

KUNDAJE, ANSHUL

 

STANFORD UNIVERSITY

 

Deep Learning Frameworks for Regulatory Genomics

 

KWONG, GABRIEL A

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Noninvasive and Predictive Biomarkers of Organ Transplant Rejection

 

LAGANOWSKY, ARTHUR D

 

TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

 

Native Ion Mobility Mass Spectrometry Studies of Potassium Inward Rectifier Channels: Insight into Gating and Lipid Binding

 

LEAL, CECILIA

 

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

 

A New Paradigm in Nanomedicine: Can Structural Interiors of Nanoparticles Regulate Cellular Delivery?

 

MADHUR, MEENAKSHI SWAMINATHAN

 

VANDERBILT UNIVERSITY

 

Immunophenotyping of Human Hypertension Using Single Cell Multiplex Mass Cytometry to Identify Novel Therapeutic Targets

 

NAIR, NIKHIL UNNI

 

TUFTS UNIVERSITY MEDFORD

 

Metabolic Engineering in Humans: Altered Gut Microbes as a Therapeutic Platform

 

PENG, TIEN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Defining the Resident Mesenchymal Stem Cell Niche and Function In Vivo

 

PERERA, RUSHIKA MIRIAM

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Tracking Tumor Evolution Through In Vivo Organelle Profiling

 

PETRY, SABINE

 

PRINCETON UNIVERSITY

 

Building the Chromosome Segregation Machinery from Scratch

 

PURVIS, JEREMY

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Controlling Stem Cell Fate Through Computational Modeling

 

ROGULJA, DRAGANA

 

HARVARD MEDICAL SCHOOL

 

Mechanisms of Arousal Threshold and Sleep Homeostasis

 

SAMUEL, MELANIE A

 

BAYLOR COLLEGE OF MEDICINE

 

Synaptic Reprogramming of Adult Neurons

 

SATIJA, RAHUL

 

NEW YORK GENOME CENTER

 

Learning the Metadata of the Cell with Single Cell Genomics

 

SCHMIDT, TIFFANY M.

 

NORTHWESTERN UNIVERSITY

 

Genetic Mapping of Visual Circuits

 

SLAVOV, NIKOLAI 

 

NORTHEASTERN UNIVERSITY

 

Ribosome-Mediated Translational Regulation during Stem Cell Differentiation

 

STAUFFER, WILLIAM RICHARD

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Neural Correlates of Optimal Value Seeking in the Reward System

 

STEINHAUSER, MATTHEW

 

BRIGHAM AND WOMEN'S HOSPITAL

 

A New Modality to Image Tumor Metabolic Heterogeneity at Subcellular Resolution

 

STEVENS, KELLY R

 

UNIVERSITY OF WASHINGTON

 

Thermogenetic Activation of Engineered Tissue for Cardiac Repair

 

TIAN, BOZHI

 

UNIVERSITY OF CHICAGO

 

Silicon-Based Injectable Micro-Gels for Non-Genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular System

 

TOETTCHER, JARED E

 

PRINCETON UNIVERSITY

 

Harnessing Optogenetics to Diagnose and Therapeutically Rewire Cancer Cell Signaling

 

UNAL, ELCIN

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Illuminating Cellular Aging Pathways Through Gametogenesis

 

VILLA, ELIZABETH

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Opening Windows into the Cell: Revealing the Molecular Architecture of the Nuclear Periphery

 

WIITA, ARUN P.

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

In Vivo Monitoring of Oxidative Protein Folding Through Time-Resolved Quantitative Mass Spectrometry

 

XUE, WEN

 

UNIV OF MASSACHUSETTS MED SCH WORCESTER

 

CRISPR-Based Modular Therapy for Precision Medicine

 

YARTSEV, MICHAEL MOSHE

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

The First Mammalian Model System for Studying Vocal Learning: A Behavioral and Neurophysiological Approach

 

 

2015 NIH Director's New Innovator Award (DP2) - RFA-RM-13-007

PI Name Institution Name Title
BARNES, ALEXANDER BENJAMIN

 

WASHINGTON UNIVERSITY

 

High-Sensitivity NMR at Room Temperature for Molecular Structure and Dynamics

 

BARSKI, ARTEM

 

CINCINNATI CHILDRENS HOSP MED CTR

 

Direct Epigenetic Reprogramming of T Cells

 

BASU, SANJAY

 

STANFORD UNIVERSITY Cohort Filtering Models to Identify Social Program Effects on Health Disparities

 

BENNETT, ERIC JOSEPH

 

UNIVERSITY OF CALIFORNIA SAN DIEGO Manipulating Protein Homeostasis Through Specialized Quality Control Ribosomes

 

BLOODGOOD, BRENDA L

 

UNIVERSITY OF CALIFORNIA SAN DIEGO Charting a New Path for Rapid Signaling from the Synapse to the Nucleus

 

BRAR, GLORIA ANN UNIVERSITY OF CALIFORNIA BERKELEY

 

Dissecting the Roles of Pervasive Short ORFs in Meiosis

 

COLE, FRANCESCA

 

UNIVERSITY OF TX MD ANDERSON CAN CTR

 

Mechanistic Derivation of Germ Line Mutation by Genome-Wide Mouse Tetrad Analysis

 

DONIA, MOHAMED ABOU

 

PRINCETON UNIVERSITY

 

Uncultivated Bacterial Symbionts of Humans: An Untapped Resource for Drug Discovery

 

DUMONT, SOPHIE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Rewiring Cellular Architecture to Probe Mechanical Signal Processing at Kinetochores

 

FELDMAN, JESSICA LYNN

 

STANFORD UNIVERSITY

 

Mechanisms Controlling Microtubule Organization during Cell Differentiation

 

FENG, LIANG

 

STANFORD UNIVERSITY

 

Molecular Mechanism and Novel Therapeutic Strategy in Alzheimers Disease

 

GANGULY, KARUNESH

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Neuroprosthetic Control of an Anthropomorphic Exoskeleton in Tetraplegics

 

GERSHOW, MARC HERMAN

 

NEW YORK UNIVERSITY

 

Dissecting Olfactory Decision Making Using Optical Neurophysiology

 

GODULA, KAMIL

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

In Vivo Glycan Engineering at the Cell-Matrix Interface to Control Stem Cell Fate

 

GOLDBERG, JESSE HEYMANN

 

CORNELL UNIVERSITY

 

Identifying Pathways for Motor Variability in the Mammalian Brain

 

IDOYAGA, JULIANA

 

STANFORD UNIVERSITY

 

Harnessing Human Dendritic Cell Subsets for the Design of Novel Immunotherapies

 

JAROSZ, DANIEL

 

STANFORD UNIVERSITY

 

Protein-Based Molecular Memories in Gene Regulation, Disease, and Development

 

JENSEN, JAKOB DANIEL

 

UNIVERSITY OF UTAH

 

Communal Feedback as an Innovative Alternative to Skin Self-Exam

 

JONIKAS, MARTIN CASIMIR

 

CARNEGIE INSTITUTION OF WASHINGTON, D.C.

 

Transforming Our Understanding of Eukaryotic Gene Functions Through Chemical Genetics in the Green Alga Chlamydomonas reinhardtii

 

KAMPMANN, MARTIN

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Rewiring of the Human Protein Homeostasis Network in Normal and Disease Contexts

 

KNIGHT, ZACHARY A.

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Sequencing Neural Circuits Controlling Thermoregulation

 

LIPOMI, DARREN J

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Stretchable, Biodegradable, and Self-Healing Semiconductors for Wearable and Implantable Sensors

 

LIU, CHANG C

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

A High-Throughput Continuous Evolution System for In Vivo Biosensor Engineering

 

MOHAN, DEEPIKA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

A Novel Intervention to Make Heuristics a Source of Power for Physicians

 

MUNRO, JAMES B

 

TUFTS UNIVERSITY BOSTON

 

Structural Dynamics of Single Ebolavirus GP Molecules

 

PASZEK, MATTHEW J CORNELL UNIVERSITY

 

Mechanobiology of the Cellular Glycocalyx

 

PHILLIPS-CREMINS, JENNIFER ELIZABETH UNIVERSITY OF PENNSYLVANIA

 

Engineering 3-D Epigenome Topology with Light

 

PRAKASH, MANU

 

STANFORD UNIVERSITY

 

Mosquitoes Meet Microfluidics: Novel Tools for Ecological Surveillance of Insect-Borne Disease

 

PRASAD, ABHISHEK

 

UNIVERSITY OF MIAMI CORAL GABLES

 

Spinal Cord Neural Interface for Neuroprosthetics in a Primate Model

 

SCHWARTZ, GREGORY WILLIAM

 

NORTHWESTERN UNIVERSITY AT CHICAGO

 

Novel Circuit Mapping Strategies to Reverse Engineer the Retina

 

SCOTT, EVAN A

 

NORTHWESTERN UNIVERSITY

 

Development of Combination Immunotherapies for Atherosclerotic Inflammation

 

SEYEDSAYAMDOST, MOHAMMAD R

 

PRINCETON UNIVERSITY

 

Implementing Innovative Approaches to Access the Hidden Metabolomes of Bacteria

 

SHALEK, ALEX K

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Bottom - Up Profiling of Interacting Cellular Systems 

 

SHOULDERS, MATTHEW DONALD

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Continuous Directed Evolution of Biomolecules in Human Cells for Medical Research 

 

SPITALE, ROBERT C

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Cracking the RNA Localization Code

 

TRAPNELL, BRUCE COLSTON

 

UNIVERSITY OF WASHINGTON

 

Charting the Regulatory Topography of the Cell Differentiation Landscape with Single-Cell RNA-Seq

 

VASEGHI, MARMAR

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Cardiac Afferent Neurotransmission and Modulation of Ventricular Parasympathetic Control

 

WARDEN, MELISSA RHOADS

 

CORNELL UNIVERSITY

 

Imaging the Evolving Neural Circuit Dynamics of Depression

 

WHITED, JESSICA L

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Leveraging Single-Cell Analysis to Elucidate Mechanisms of Vertebrate Limb Regeneration

 

YU, MIN UNIVERSITY OF SOUTHERN CALIFORNIA

 

Developing Individualized Medicine Targeting Metastatic Breast Cancer Stem Cells

 

ZHANG, WENJUN

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

In Situ Natural Product Labeling and Applications

 

 

2014 NIH Director's New Innovator Award (DP2) - RFA-RM-13-007

PI Name Institution Name Title
ABATE, ADAM R.

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Microfluidic Immunoprofiling for Biomarker Discovery in Rheumatoid Arthritis

 

ACAR, MURA

 

YALE UNIVERSITY

 

Quantitative Real-Time Characterization of Single-Cell Aging: From Phenotypes to Lifespan

 

ANDE, SATYANARAYANA

 

GEORGIA REGENTS UNIVERSITY CANCER CENTER

 

A Multifaceted Approach to Target Obesity

 

ANDERMANN, MARK L

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

Multiphoton Imaging of Thoughts of Food during Natural and Induced Hunger States

 

ANTHONY, ROBERT MCCULLOUGH

 

HARVARD MEDICAL SCHOOL

 

Glycoengineering In Vivo

 

ARDEHALI, REZA

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Exploring Heterogeneity of Cardiac Fibroblasts to Reverse Fibrosis

 

ARORA, MANISH

 

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

 

Reconstructing Fetal Toxicant Exposure and Homeostatic Disruptions

 

AYE, YIMON

 

CORNELL UNIVERSITY

 

Deconvoluting Redox Biology with Targeted Chemistry

 

BASSIK, MICHAEL C

 

STANFORD UNIVERSITY

 

Accelerating Drug Development and Repurposing Using Systematic Genetic Interaction Maps in Mammalian Cells

 

BONASIO, ROBERTO

 

UNIVERSITY OF PENNSYLVANIA

 

Studying Epigenetic Pathways in Brain Function and Social Behavior Using Ants

 

BORAD, MITESH

 

MAYO CLINIC ARIZONA

 

Oncolytic Virotherapy in Hepatocellular Cancer

 

BUSCHMAN, TIMOTHY J.

 

PRINCETON UNIVERSITY

 

Developing an Adaptive Cognitive Prosthetic to Replace Damaged Brain Regions

 

CANG, HU

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Ultra Sensitive Single Molecule Spectroscopy with Plasmonic Antennas

 

CISSE, IBRAHIM

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Imaging Transcription with Single Molecule Resolution in Live Mammalian Cells

 

COBEY, SARAH

 

THE UNIVERSITY OF CHICAGO

 

Modeling the Evolutionary Dynamics of Immunity to Influenza for Vaccine Development

 

GARNER, ETHAN CLARK

 

HARVARD UNIVERSITY

 

Dissecting Bacterial Cell Wall Synthesis Using In Vivo Single Molecule Tracking

 

GLICKFELD, LINDSEY L

 

DUKE UNIVERSITY

 

Context-Dependent Changes in Local and Long-Range Cortical Circuits

 

GOODWIN, ANDREW P.

 

UNIVERSITY OF COLORADO

 

Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms

 

HALLEM, ELISSA ANYON

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

The Neural Basis of Odor-Driven Behavior in Skin-Penetrating Parasitic Nematodes

 

HENDON, CHRISTINE P

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

High Resolution Imaging of the Myocardium

 

HUH, DONGEUN

 

UNIVERSITY OF PENNSYLVANIA

 

Probing the Physics of Chronic Lung Disease Using Microphysiological Biomimicry

 

INGOLIA, NICHOLAS T

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Molecular Basis and Cellular Roles of Translational Regulation

 

JANELSINS, MICHELLE C

 

UNIVERSITY OF ROCHESTER

 

Clinical and Translational Approaches to Cognitive Impairments in Cancer

 

KADOCH, CIGALL

 

DANA-FARBER CANCER INSTITUTE

 

Reversing Oncogenic BAF Complex Structure & Function: New Therapeutic Approaches

 

KOSURI, SRIRAM

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Reverse Genomics of Regulatory Elements Governing Splicing

 

KREEGER, PAMELA K

 

UNIVERSITY OF WISCONSIN-MADISON

 

Analysis of How Quantitative Cellular Network Variation Impacts Tumor Progression

 

LANDER, GABRIEL CEDRIC

 

THE SCRIPPS RESEARCH INSTITUTE

 

Molecular Basis of Axonal Transport Described by High-Resolution 3D Imaging

 

LIN, CHENXIANG

 

YALE UNIVERSITY

 

Cell-Free Membrane Remodeling Guided by DNA Nano-Templates

 

LIPOVICH, LEONARD

 

WAYNE STATE UNIVERSITY

 

Life, Death, and Function: The Primate-Specific Long Non-Coding RNA Transcriptome

 

MARTIN, BRENT RANDALL

 

UNIVERSITY OF MICHIGAN

 

Multiscale Chemical Approaches to Map Oxidative Stress

 

MCALPINE, MICHAEL

 

UNIVERSITY OF MINNESOTA

 

3D Printed Nano-Bionic Organs
MURTHY, MALA

 

PRINCETON UNIVERSITY

 

How Does the Brain Solve the Pattern Recognition Problem?

 

NEUERT, GREGOR

 

VANDERBILT UNIVERSITY

 

Decoding the Noncoding Genome: lncRNA Dynamics and Function in Single Cells

 

ROSENBLUM, MICHAEL DAVID

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Functional Manipulation of Memory Regulatory T cells in Skin

 

ROUND, JUNE LOUISE

 

UNIVERSITY OF UTAH

 

Developing Therapies to Target the Microbiota

 

SCHOGGINS, JOHN W.

 

UT SOUTHWESTERN MEDICAL CENTER

 

Discovery of Antiviral Mechanisms in Bats

 

SFEIR, AGNEL

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Telomere-Independent Strategies to Protect Chromosome Ends

 

SIMON, MATTHEW DAVID

 

YALE UNIVERSITY

 

Integrating RNAs into Signaling Pathways by Engineering Covalent RNA Modification

 

STABENFELDT, SARAH E

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out

 

TAGA, MICHIKO E

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Targeted Killing of Bacteria in Communities

 

TIAN, LIN

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

Fluorescent Biosensors for Imaging Neurotransmitters: Observing Synapses in Action

 

WAN, LEO Q.

 

RENSSELAER POLYTECHNIC INSTITUTE

 

Cell Chirality Based In Vitro Models for Embryonic Development and Abnormalities

 

WESTREICH, DANIEL J

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

From Patients to Policy: Innovative Epidemiology for Implementation Science

 

XU, RONG

 

CASE WESTERN RESERVE UNIVERSITY

 

Rapid Reverse Translational Drug Repositioning

 

YANG, LEI

 

UNIVERSITY OF PITTSBURGH

 

Toward Regeneration of Whole Bioartificial Human Heart

 

YANG, LILI

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Stem Cell-Engineered Invariant Natural Killer T Cells for Cancer Therapy

 

ZHANG, LIJIE GRACE

 

GEORGE WASHINGTON UNIVERSITY

 

A Novel 3D Bioprinted Smart Vascularized Nano Tissue

 

ZHAO, WEIAN

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Mechano-Sensing Stem Cells to Study, Detect and Treat Cancer Metastases

 

ZONCU, ROBERTO

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Engineering Organelle Function to Rewire Cancer Cell Metabolism

 

ZONG, CHENGHANG

 

BAYLOR COLLEGE OF MEDICINE

 

Detecting the Onset of Genome Heterogeneity in Tumor at Single Cell Resolution

 

 

2013 NIH Director's New Innovator Award (DP2) - RFA-RM-12-016

PI Name Institution Name Title
ADESNIK, HILLEL

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

New Optical Strategies to Unlock the Neural Basis of Perception

 

AHERN, JENNIFER

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

A Rigorous System to Determine the Health Impacts of Policies and Programs

 

ALDRIDGE, BREE BEARDSLEY

 

TUFTS UNIVERSITY BOSTON

 

Quantitative Design of Multi-Drug Regiments for Tuberculosis

 

ATON, SARA J

 

UNIVERSITY OF MICHIGAN

 

Linking Network Activity and Intracellular Plasticity Mechanisms During Sleep-Dependent Memory Consolidation
BLISH, CATHERINE A

 

STANFORD UNIVERSITY

 

Harnessing Natural Killer Cell Memory to Fight Viruses

 

CRAWFORD, JASON MICHAEL

 

YALE UNIVERSITY

 

Cryptic Gut Bacterial Metabolites that Regulate Colorectal Cancer Formation

 

DAR, ARVIN

 

MOUNT SINAI SCHOOL OF MEDICINE

 

Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase

 

DEO, RAHUL CHANDRAKANT

 

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

 

Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies

 

DIEHN, MAXIMILIAN

 

STANFORD UNIVERSITY

 

Developing a Genomic Approach for Cancer Screening

 

DVORIN, JEFFREY D

 

CHILDREN'S HOSPITAL CORPORATION

 

Essential Gene Discovery in the Malaria Parasite Plasmodium falciparum

 

ESSER-KAHN, AARON PALMER UNIVERSITY OF CALIFORNIA IRVINE

 

Directing the Immune System via Polymeric Combinations of Molecular Signals

 

EVANS, SCOTT E

 

UT MD ANDERSON CANCER CTR

 

Inducible Epithelial Antiviral Resistance to Prevent Asthma

 

FIEDLER, DOROTHEA

 

PRINCETON UNIVERSITY

 

Understanding Phosphate Metabolism in Cancer and Metastasis

 

FROST, ADAM

 

UNIVERSITY OF UTAH

 

Toward Atomic Resolution of Membranes and Membrane-Associated Machines

 

GANDHI, SUNIL

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Rewiring Cortex Using Inhibitory Neuron Transplantation

 

GARTNER, ZEV JORDAN

 

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

 

Total Synthesis of the Human Mammary Gland

 

GRADINARU, VIVIANA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Neuromodulation and Neurodegeneration: The Missing Link and Mechanisms of Action

 

GREGG, ROBERT D

 

UNIVERSITY OF TEXAS DALLAS

 

Phase-Based Control of Locomotion for High-Performance Prostheses and Orthoses

 

HANSEN, SCOTT B

 

SCRIPPS FLORIDA

 

Molecular Mechanism of Mechanosensation

 

LAMB, TRACEY JANE

 

EMORY UNIVERSITY

 

The Development of Probiotic Yeast as an Inexpensive Vaccine Delivery Platform

 

LUCKS, JULIUS BEAU

 

CORNELL UNIVERSITY

 

A New High-Throughput Technology to Reveal the Dynamic Functional States of RNAs

 

MARR, LINSEY

 

VIRGINIA POLYTECHNIC INST AND ST UNIV

 

The Role of Pathogen-Environment Interactions in the Pandemic Potential of Influenza

 

MERRIKH, HOURA

 

UNIVERSITY OF WASHINGTON

 

Targeted Gene Evolution via Replication-Transcription Conflicts

 

MORTAZAVI, SEYED ALI

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Comparative Analysis of the 4D Encoding of Regulatory Networks in Stem Cells

 

O'CONNELL, RYAN

 

UNIVERSITY OF UTAH

 

Utilizing TALEN Technology to Regulate Human microRNAs

 

ONNELA, JUKKA-PEKKA

 

HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)

 

Using Mobile Phones for Social and Behavioral Sensing of Mood Disorder Patients

 

PETERSEN, CHRISTIAN

 

NORTHWESTERN UNIVERSITY

 

Regulatory Circuits Controlling Regenerative Growth

 

PEYTON, SHELLY R

 

UNIVERSITY OF MASSACHUSETTS AMHERST

 

Tissue-Specific Stem Cells and Breast Cancer Tissue Tropism

 

RUTA, VANESSA

 

ROCKEFELLER UNIVERSITY

 

Connecting Neural Plasticity to Learning and Memory

 

SAHIN, OZGUR

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Novel Sub-Cellular Chemical and Mechanical Nanoimaging

 

SANJABI, SHOMYSEH

 

J. DAVID GLADSTONE INSTITUTES

 

Characterizing HIV Latent Reservoir In Vivo

 

SATTELY, ELIZABETH SUSAN

 

STANFORD UNIVERSITY

 

Liberation of Plant Nutrients by the Gut Microbiota

 

SAVAGE, DAVID FRANK

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Fluorescent Biosensors for Metabolite Imaging in Live Cells

 

SEANDEL, MARCO

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Clonal Competition in Stem Cells as a Driver of Paternal Age Effect Diseases

 

SIVARAMAKRISHNAN, SIVARAJ UNIVERSITY OF MICHIGAN

 

The Kinase Toolbox: Mapping the Spatial and Temporal Regulation of Cell Signaling

 

TAYLOR, DEREK JAMES

 

CASE WESTERN RESERVE UNIVERSITY

 

Induction of Cancer Cell Death by Selective DNA Misincorporation

 

TISCHLER, ANNA DEGRAFF

 

UNIVERSITY OF MINNESOTA

 

High-Throughput Identification of Mycobacterium tuberculosis Persistence Mechanism

 

TYE, KAY MAXINE

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits

 

WHITE, RICHARD MARK

 

SLOAN-KETTERING INST CAN RES

 

Evolutionary Dynamics of Melanoma Metastasis

 

WONG, WILSON

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) Synthetically Reengineered T Cells as the Next Generation of Smart Cancer Therapy

 

ZHENG, YING

 

UNIVERSITY OF WASHINGTON

 

A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis

 

 

2012 NIH Director's New Innovator Award (DP2) - RFA-RM-11-005

PI Name Institution Name Title
ALLEN, CHRISTOPHER DAVID UNIVERSITY OF CALIFORNIA SAN FRANCISCO Cellular Interactions in Asthma

 

AUGUSTE, DEBRA

 

HARVARD UNIVERSITY

 

Personalized Therapeutics for Inhibiting Breast Cancer Metastasis

 

BALSKUS, EMILY PATRICIA

 

HARVARD UNIVERSITY

 

Biocompatible Chemistry for In Vivo Metabolite Modification

 

BIVONA, TREVER G

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Discovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment

 

BONKOWSKY, JOSH LEITCH

 

UNIVERSITY OF UTAH

 

Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganization

 

BORENSTEIN, ELHANAN

 

UNIVERSITY OF WASHINGTON

 

A Computational Framework for Designing Microbiome Manipulation

 

BRANGWYNNE, CLIFFORD P

 

PRINCETON UNIVERSITY

 

Cell Growth Control by Cell and Organelle Size-Dependent Ribosome Biogenesis

 

CAMP, AMY HITCHCOCK

 

LEHIGH UNIVERSITY

 

A Feeding Tube Model for Bacterial Cell-Cell Communication

 

CARETTE, JAN EDUARD

 

STANFORD UNIVERSITY

 

Genetic Approaches to Discover Host Factors Critical to Dengue Virus Infection

 

CHEN, SHUIBING

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Studying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabetes Mellitus Using Humanized Mouse Models

 

CHI, PING

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

An Integrative Approach to Target Lineage-Specific Oncogenic Transcription Factor

 

CHURCHLAND, MARK

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

A Dynamical Systems Approach to Fundamental Questions in Neuroscience

 

CUI, BIANXIAO

 

STANFORD UNIVERSITY

 

Engineering External Forces for Manipulating Cargo Transport in Live Neurons

 

DANTAS, GAUTAM

 

WASHINGTON UNIVERSITY

 

Metagenomic Engineering of Probiotic Bacteria to Improve Intestinal Colonization

 

DONG, P. DUC SI

 

SANFORD-BURNHAM MEDICAL RESEARCH INSTIT

 

Unlocking Regenerative Potential Through In Vivo Genetic Reprogramming

 

FALK, EMILY

 

UNIVERSITY OF PENNSYLVANIA

 

Can Neuroscience Dramatically Improve Our Ability to Design Health Communications

 

FEINBERG, ADAM WALTER

 

CARNEGIE-MELLON UNIVERSITY

 

Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds

 

GILL, HARVINDER SINGH

 

TEXAS TECH UNIVERSITY

 

Pollen Grains as Trojan Horses for Oral Vaccination

 

GOODMAN, ANDREW L

 

YALE UNIVERSITY

 

Defining the Contribution of Interpersonal Microbial Variation to Drug Metabolism

 

GORE, JEFF

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Early Warning Indicators of Tipping Points in Biological Systems

 

HAN, XUE

 

BOSTON UNIVERSITY

 

Light-Actuatable NanoRobots for Molecular Uncaging

 

HELLER, DANIEL ALAN

 

MEMORIAL SLOAN KETTERING CANCER CENTER

 

Transient Metabolite Detection for Single-Cell Metabolomics and Diagnostics

 

HIGGINS, JOHN MATTHEW

 

MASSACHUSETTS GENERAL HOSPITAL

 

Systems Biology of In Vivo Human Blood Cell Populations

 

JOHNSON, LAURA A

 

UNIVERSITY OF PENNSYLVANIA

 

Gene-Engineered Adoptive T Cell Immunotherapy of GBM

 

KOHLI, RAHUL MANU

 

UNIVERSITY OF PENNSYLVANIA

 

Combating Bacterial Drug Resistance by Targeting the Enzymes of Evolution

 

KRONAUER, DANIEL

 

ROCKEFELLER UNIVERSITY

 

Studying the Molecular Mechanisms of Social Life Using a Novel Ant Model System 

 

LILLEMEIER, BJOERN F.

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Decipher Membrane Patterns In Situ with Super-Resolution and Dynamic Microscopy

 

LIU, ALLEN PO-CHIH

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Building Artificial Platelets

 

LIU, WENDY

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Engineering Biomaterials to Exert Molecular Control of Immune Cell Function

 

MAIMON, GABY

 

ROCKEFELLER UNIVERSITY

 

Linking Genes to Higher Brain Function by Way of Cellular Electrophysiology

 

MARRAFFINI, LUCIANO A

 

ROCKEFELLER UNIVERSITY

 

Using CRISPR Immunity to Prevent the Spread of Virulence Traits Among Pathogens

 

MIN, WEI

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Label-Free Chemical Imaging for Biological Applications

 

MYONG, SUA

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Quantitative Stepwise Analysis of RNA Interference

 

NIELL, CRISTOPHER

 

UNIVERSITY OF OREGON

 

Connecting Developmental Mechanisms to Visual Function and Perception

 

NIMMERJAHN, AXEL

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Novel Approaches to Study Microglia Physiology and Pathology in the Intact Brain

 

PERMAR, SALLIE R.

 

DUKE UNIVERSITY

 

Maternal Immune Protection Against Congenital CMV Infection

 

PERTSINIDIS, ALEXANDROS

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

Understanding Gene Transcription from First-Principles: A Single-Molecule Study

 

PRLIC, MARTIN

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Paving the Way for a Novel Therapeutic Approach to Combat HIV

 

RODAL, AVITAL ADAH

 

BRANDEIS UNIVERSITY

 

Activity-Dependent Regulation of Membrane Traffic and Growth Signaling in Neurons

 

ROHATGI, RAJAT

 

STANFORD UNIVERSITY

 

Reconstructing Primary Cilia

 

SCHAEFER, ANNE

 

MOUNT SINAI SCHOOL OF MEDICINE

 

Cognate Microglia-Neuron Interaction and Its Role in Inflammation

 

SHU, XIAOKUN

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

New Principle-Based Technologies for Identifying Transient Protein Interactions

 

SOHAL, VIKAAS SINGH

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Reverse Engineering the Prefrontal Microcircuit

 

STOLTZ, DAVID A

 

UNIVERSITY OF IOWA

 

Airway Goblet Cells: Friend or Foe?

 

SU, MING

 

NORTHEASTERN UNIVERSITY

 

Enhanced Radiation Therapy with Nanoscale Frequency Modulators

 

URBAN, ALEXANDER ECKEHART

 

STANFORD UNIVERSITY

 

Genomic and Epigenomic Effects of Large CNV in Neurons from iPSC

 

WITTEN, ILANA

 

PRINCETON UNIVERSITY

 

Therapeutic Plasticity: A Novel Paradigm for Treating Addiction

 

WOODROW, KIM A.

 

UNIVERSITY OF WASHINGTON

 

Nanomaterials for Engineering Protection in the Genital Mucosa

 

YOO, ANDREW

 

WASHINGTON UNIVERSITY

 

MicroRNA and Neural Factor-Mediated Direct Reprogramming of Cell Fates

 

ZHENG, SIYANG

 

PENNSYLVANIA STATE UNIVERSITY-UNIV PARK

 

Integration of Flexible Micro Spring Array and High Throughput Microfluidics for Obtaining Clinical Relevant Information from Circulating Tumor Cells
ZOVEIN, ANN CAPELA

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Engineering Human Endothelium for Hematopoietic Stem Cell Production

 

 

2011 NIH Director's New Innovator Award (DP2) - RFA-RM-10-009

PI Name Institution Name Title
ALLER, STEPHEN G

 

UNIVERSITY OF ALABAMA AT BIRMINGHAM

 

Streamlined Structures of Human Integral Membrane Proteins at Atomic Resolution

 

BAKER, AARON BLAIR

 

UNIVERSITY OF TEXAS AUSTIN

 

Engineering Effective Revascularization Strategies for Ischemia in Disease States

 

BARNA, MARIA

 

STANFORD UNIVERSITY

 

Specialized Ribosomes in Control of Gene Expression and Embryonic Development

 

BASU, UTTIYA

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Non-Coding RNA Engineers Antibody Diversity

 

BUCHLER, NICOLAS EMILE

 

DUKE UNIVERSITY

 

Rewiring the Yeast Brain: Redundancy and Interference in Genetic Networks

 

CAI, LONG

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Systems Biology in Single Cells by Super-Resolution Barcoding

 

CANMAN, JULIE C

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

IR-LAMP: Optigenetic Technology to Spatially Manipulate Protein Function In Vivo

 

CARLSON, ERIN ELIZABETH

 

UNIVERSITY OF MINNESOTA

 

Targeted Natural Product Diversification to Identify Novel Antibacterial Agents

 

CHANG, EDWARD

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Functional Architecture of Human Speech Motor Cortex

 

CHANG, JOHN T

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Understanding the Basis for Cellular Diversity During Adaptive Immunity

 

CHANG, MICHELLE C

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Discovery and Mechanistic Study of Fluorine Biochemistry

 

CHENG, WEI

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Single Cell with One Particle Entry (SCOPE) for Study of HIV Infection

 

CHRISTOFK, HEATHER RENEE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Regulation of the Warburg Effect in Cancer

 

FRASER, HUNTER B

 

STANFORD UNIVERSITY

 

Systematic Functional Annotation of Human Cis-Regulatory Genetic Variation

 

GERSBACH, CHARLES A

 

DUKE UNIVERSITY

 

Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming

 

GEURTS, ARON M

 

MEDICAL COLLEGE OF WISCONSIN

 

Advanced Genetic Engineering Technology Development

 

GIANNESCHI, NATHAN CLAUDE

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Programming Pharmacokinetics In Vivo via In Situ Switching of Nanoscale Particle Morphology

 

GOENTORO, LEA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Relative Perception in Wnt Signaling

 

HAMMOND, MING CHEN

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

A Chemical Biology Approach to Tagging RNAs in Live Cells

 

HAN, SONGI

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Probing Early Protein Aggregation Mechanisms and Their Relationship to Disease Effects Through the Innovation of Highly Amplified and Time-Resolved Electron-Nuclear Spin Magnetic Resonance

 

HUANG, BO

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Solving Macromolecular Complex Architecture In Situ by Super-Resolution Microscopy

 

HUG, CHRISTOPHER

 

CHILDREN'S HOSPITAL BOSTON

 

Macrophage Integrated and Targeted Yeast Therapeutics

 

JIANG, HONGRUI

 

UNIVERSITY OF WISCONSIN MADISON

 

Accommodative Contact Lens for Presbyopic Correction

 

KALANTRY, SUNDEEP

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Initiation of Epigenetic Transcriptional Regulation

 

KASKO, ANDREA MARIE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Phototunable Biomaterials to Engineer Complex 3D Cell Microenvironments

 

KING, MEGAN C

 

YALE UNIVERSITY

 

The Role of Nuclear Architecture in Adaptation

 

KOSAK, STEVEN TODD

 

NORTHWESTERN UNIVERSITY

 

Self-Organization of the Human Genome

 

LAMICHHANE, GYANU

 

JOHNS HOPKINS UNIVERSITY

 

New Drug for Treatment of Chronic Bacterial Infection

 

LEE, SEOK-YONG

 

DUKE UNIVERSITY

 

Pharmacology and Biophysics of the Voltage-Gated Sodium Channel Nav1.7: A Therapeutic Target for Pain

 

LEE, SHAUN W

 

UNIVERSITY OF NOTRE DAME

 

Design and Use of Novel Bacteriocins

 

LIEBERMAN AIDEN, EREZ

 

BROAD INSTITUTE, INC.

 

Exploring How the Genome Folds Through Proximity Ligation and Sequencing

 

LU, TIMOTHY

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

High-Throughput Nanoscale Approaches to Studying and Inhibiting Amyloid Toxicity

 

MAVERAKIS, EMANUAL M

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Investigation and Development of New Therapeutic Avenues for Scleroderma

 

MITCHELL, DOUGLAS ALAN

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

A Common Denominator of Pathogenesis; A Rare Opportunity for Novel Therapeutic Development

 

OTT, HARALD C

 

MASSACHUSETTS GENERAL HOSPITAL

 

Organ Engineering Based on Perfusion Decellularized Matrix

 

PADERA, TIMOTHY P.

 

MASSACHUSETTS GENERAL HOSPITAL

 

Characterizing Lymphatic Micrometastases: Prognostic and Therapeutic Implications

 

PAEGEL, BRIAN M

 

SCRIPPS FLORIDA

 

Evolving and Engineering New Protease Tools for Mass Spectrometry Proteomics

 

PETRASCHECK, MICHAEL

 

SCRIPPS RESEARCH INSTITUTE

 

Modulation of Sensory Perception to Treat Age Related Disease

 

QUEITSCH, CHRISTINE

 

UNIVERSITY OF WASHINGTON

 

Does Organismal Robustness Explain the Missing Heritability in Complex Diseases?

 

RAJ, ARJUN

 

UNIVERSITY OF PENNSYLVANIA

 

Comprehensive Spatial Picture of Transcription in the Nucleus

 

SCHLIEKER, CHRISTIAN DIRK

 

YALE UNIVERSITY

 

Deciphering Novel Protein Quality Control Pathways in the Nuclear Periphery

 

TOBIN, DAVID M

 

DUKE UNIVERSITY

 

Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-Directed Therapy

 

WANG, CHIHHUNG JASON

 

BOSTON MEDICAL CENTER

 

Healthy Ideas Exchange

 

WEIBEL, DOUGLAS BENJAMIN

 

UNIVERSITY OF WISCONSIN MADISON

 

Revisiting the Bacterial Cell Wall as a Target for New Antibiotics

 

WINGERT, REBECCA ANN

 

UNIVERSITY OF NOTRE DAME

 

Identification of Kidney Regeneration Mechanisms Using the Zebrafish

 

WU, JOY Y

 

MASSACHUSETTS GENERAL HOSPITAL

 

In Vivo Reconstitution of the Hematopoietic Niche

 

XAVIER, JOAO

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

Engineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies

 

ZHANG, QI

 

VANDERBILT UNIVERSITY

 

Explore Fundamental Aspects of Neurotransmission with Multifunctional Nanosensor

 

ZHONG, HAINING

 

OREGON HEALTH AND SCIENCE UNIVERSITY

 

Examining the Architecture of Synapses in Brain Tissue at Nanometer Resolution

 

 

2010 NIH Director's New Innovator Award (DP2) - RFA-RM-09-011

PI Name Institution Name Title
AGAR, NATHALIE YR

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Real-Time Stereotactic Mass Spectrometry Tissue Analysis for Intraoperative Neuro

 

AGARWAL, RITESH

 

UNIVERSITY OF PENNSYLVANIA

 

Optoelectronic Nanowire Probes for Investigation of Intra-Cellular Processes

 

AMARO, ROMMIE E

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

A Structural Systems Biology Approach to Drug Discovery

 

ARAVIN, ALEXEI A

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Taming of Small RNA-based Epigenetic Mechanisms

 

ARMANI, ANDREA MARTIN

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Ultrasensitive Nanolasers for Epigenetics Investigations

 

BAUTISTA, DIANA MICHELE

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

New Approaches to Identify Molecular Mechanisms of Touch and Pain in Mammals

 

CEGELSKI, LYNETTE S

 

STANFORD UNIVERSITY

 

Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation

 

CHENG, JIANJUN

 

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

 

Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates

 

CHI, NEIL C

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Directed Cardiac Cellular Programming: A New Paradigm for Cardiac Regeneration

 

COHEN, ADAM EZRA

 

HARVARD UNIVERSITY

 

Optical Sensing of Voltage, pH, and Small Molecules Using Microbial Rhodopsins

 

DAI, CHENGKAI

 

JACKSON LABORATORY

 

Role of a Novel Stress Response Mechanism-Genetic Buffering-in Tumor Evolution

 

DATTA, SANDEEP R

 

HARVARD MEDICAL SCHOOL

 

Revealing Fear: New Methods to Study Neural Circuits, Behavior and Disease

 

DI CARLO, DINO

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Engineering the Intracellular Micro- and Nanoenvironment

 

DUNN, ALEXANDER R

 

STANFORD UNIVERSITY

 

Uncovering New Roles for Mechanical Force in Tissue Development and Remodeling

 

EVANS, CONOR LEE

 

MASSACHUSETTS GENERAL HOSPITAL

 

Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer

 

FELDMAN, BRIAN J

 

STANFORD UNIVERSITY

 

Using Components of the Circadian Clock to Regulate Stem Cell Fate Decisions

 

FELIPPE, MARIA JULIA BEVILAQUA

 

CORNELL UNIVERSITY

 

Epigenetics: A Novel Approach in Primary Immunodeficiencies

 

FISCHBACH, MICHAEL ANDREW

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Identifying and Characterizing Small Molecules from the Human Microbiome

 

GARCIA, BENJAMIN A

 

PRINCETON UNIVERSITY

 

Novel Methodology for Quantitative High-Throughput Cancer Epigenetics

 

GUERRERO, THOMAS M

 

UNIVERSITY OF TX MD ANDERSON CAN CTR

 

Spatially Accurate Deformable Image Registration for Thoracic CT Application

 

GUZMAN, MONICA L

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Selection of Novel Therapies to Ablate Chemoresistant Myeloid Leukemia Stem Cell

 

HERR, AMY ELIZABETH

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Towards High Throughput Proteomics: A Micro/nanofluidic Framework for Blotless Western Technology

 

HOTOPP, JULIE

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Impact of Bacterial-Animal Lateral Gene Transfer on Human Health

 

HUANG, TONY JUN

 

PENNSYLVANIA STATE UNIVERSITY-UNIV PARK

 

On-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection

 

HUANG, YU

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Graphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biologic

 

KHINE, MICHELLE

 

UNIVERSITY OF CALIFORNIA-IRVINE

 

Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)

 

KLEIN, OPHIR D

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

An Evolutionary-Developmental Approach to Stem Cells Using Teeth as a Model

 

KRITZER, JOSHUA A

 

TUFTS UNIVERSITY MEDFORD

 

Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept

 

LAIRD, DIANA J

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Cell Competition in the Developing Mouse Germline

 

LAVIK, ERIN

 

CASE WESTERN RESERVE UNIVERSITY

 

Clinically Translatable Nanotechnology: Hemostasis and Neuroprotection

 

LEE, JIN HYUNG

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

In Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration

 

LEVY, HARA

 

MEDICAL COLLEGE OF WISCONSIN

 

Integration of Genomics with Genetics - Molecular Phenotypes for CF Lung Disease

 

LEY, RUTH EMILY

 

CORNELL UNIVERSITY

 

Development of Immunization Strategies to Reshape Pathogenic Microbiomes

 

LUO, MINKUI

 

SLOAN-KETTERING INST CAN RESEARCH

 

Enzyme-Engineering Approaches to Dissect Protein Methylation Profiles

 

MAJOR, MICHAEL BENJAMIN

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

Exploitation of Near-Haploid Human Cells for Functional Gene Discovery

 

MARCH, JOHN C

 

CORNELL UNIVERSITY

 

Engineering Commensal Bacteria as Therapeutic Signal Mediators

 

NELSON, TIMOTHY JAMES

 

MAYO CLINIC ROCHESTER

 

Dysfunctional Regeneration in Cardiomyopathy: iPS-Based Diagnosis and Therapy

 

NICULESCU, ALEXANDER B

 

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

 

Developing Blood Tests for Mood Disorders

 

NILES, JACQUIN C

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Engineered Regulated RNA Localization and Transport in Biological Systems

 

NOLAN, ELIZABETH M

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology

 

PLATT, MANU O

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Multiscale, Mechanistic, and Predictive Models of Stroke in Sickle Cell Disease

 

SEALE, PATRICK

 

UNIVERSITY OF PENNSYLVANIA

 

Molecular Regulation of Brown Adipose Cell Fate in Somitic Stem Cells

 

SITHARAMAN, BALAJI

 

STATE UNIVERSITY NEW YORK STONY BROOK

 

Nanotechnology-Based Theranostic Technology for Bone Tissue Engineering

 

THEOGARAJAN, LUKE SATISH KUMAR

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Bio-Ionic Neural Interfaces

 

TUCKER, BUDD A

 

UNIVERSITY OF IOWA

 

Development of a Cell Replacement Therapy to Treat Retinal Degenerative Blindness

 

WADE, JOSEPH THOMAS

 

WADSWORTH CENTER

 

Pervasive Transcription in Bacterial Genomes

 

WEISS, LAUREN ANNE

 

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

 

Dissecting Epistasis and Pleiotropy in Autism Towards Personalized Medicine

 

WONG, PAK KIN

 

UNIVERSITY OF ARIZONA

 

Mechanoregulation of Tissue Morphogenesis

 

YANG, CHANGHUEI

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Applications of Time-Reverse Tissue Turbidity Suppression to Improve Biophotonics

 

YIN, PENG

 

HARVARD MEDICAL SCHOOL

 

Engineering Bioimaging Probes Based on Triggered Molecular Geometry

 

ZHAO, XILIN

 

UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL

 

Anaerobic Shock as a Novel Treatment for Tuberculosis

 

ZHONG, SHENG

 

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

 

Evolutionary Models for Gene Regulatory Networks

 

 

2009 NIH Director's New Innovator Award (DP2) - RFA-RM-09-003

PI Name Institution Name Title
ALBERS, MARK W

 

MASSACHUSETTS GENERAL HOSPITAL

 

The Olfactory Neural Circuit as a Systems Level Model of Neurodegenerative Disease

 

ALMUTAIRI, ADAH

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Chemically Amplified Response Strategies for Medical Sciences; Concepts Borrowed from the Electronics Industry

 

ASHLEY, EUAN A

 

STANFORD UNIVERSITY

 

Nanoscale Approaches to Allelic Silencing in Myocardial Disease States

 

BAGNAT, MICHEL

 

DUKE UNIVERSITY

 

Discovering New Regulators of CFTR and Fluid Secretion in Zebrafish

 

BALAZSI, GABOR

 

UNIVERSITY OF TEXAS MD ANDERSON CAN CTR

 

Connecting the Selection of Noisy Gene Expression Deviants to Genetic Evolution

 

BANERJEE, IPSITA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Defining Mechanisms Controlling Stem Cell Fate during DifferentiationARRA Logo

 

BROWN, EDWARD BERNARD

 

UNIVERSITY OF ROCHESTER

 

Exploiting Collagen Organization to Predict and Prevent Tumor Metastasis

 

CAMARGO, FERNANDO

 

CHILDREN'S HOSPITAL BOSTON

 

Analysis of Stem Cell Dynamics and Differentiation by Cellular BarcodingARRA Logo

 

CHRONIS, NIKOLAOS

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

A Biochip for Point-of-Care HIV/AIDS Diagnosis in the Developing WorldARRA Logo

 

COHEN THEODORE H

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Prevalence, Risk Factors and Consequences of Complex M. tuberculosis Infections

 

DERIEMER, KATHRYN

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Transmission and Virulence of Mycobacterium tuberculosis

 

DIAZ, ELVA D

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Generation of Tumor Stem Cell Lines for Directed Therapeutics of Brain Cancer

 

ENGLER, ADAM JEFFREY

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

"Smart" Materials to Engineer a More Complete Stem Cell Niche

 

GRISHOK, ALLA

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Investigating the Potential of Endogenous RNAi in Mediating Adaptation to Environment

 

HALL, IRA M

 

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE

 

Extent, Origin, and Control of Structural Variation in Mammalian Genomes

 

HEILSHORN, SARAH C

 

STANFORD UNIVERSITY

 

Engineering 3D In Vitro Niches to Reveal Fundamentals of Cellular Biomechanics

 

HUANG KERWYN CASEY

 

STANFORD UNIVERSITY

 

Engineering of Cell Shape and Intracellular Organization

 

JAIN, SANJAY

 

JOHNS HOPKINS UNIVERSITY

 

Novel Imaging Biomarkers to Address Fundamental Controversies in TB Pathogenesis

 

JANES, KEVIN A.

 

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE

 

Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein

 

KEMP, MELISSA LAMBETH

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Redox Regulation of Cellular Information Processing

 

KREIMAN, GABRIEL

 

CHILDREN'S HOSPITAL BOSTON

 

Towards the Neuronal Correlates of Visual Awareness

 

KRISTICH, CHRISTOPHER J

 

MEDICAL COLLEGE OF WISCONSIN

 

Genetic Approaches to Protein-Protein Interactions Mediating Antibiotic Resistance

 

KURDISTANI, SIAVASH

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

A Blueprint for Oncogenic Epigenetic Reprogramming

 

KWATE, NAA OYO A

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the HPA Axis, and African American Health

 

LEE, KIBUM

 

RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

 

Combinatorial Approaches for Studying Multiple Cues Regulating Human Pluripotent Stem Cell (hPSC) Fate

 

LIM, DANIEL A

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Chromatin-Based Cellular Memory in Neural Stem Cells

 

LOMVARDAS, STAVROS

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Characterization of the Role of CpA Methylation in Neuronal Plasticity

 

MACHADO, ANDRE GUELMAN

 

CLEVELAND CLINIC LERNER COL/MED-CWRU

 

Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Modulation of the Affective Sphere of Chronic Neuropathic Pain

 

MASOPUST, DAVID

 

UNIVERSITY OF MINNESOTA TWIN CITIES

 

Maximizing CD8 T Cells for Protection

 

MORA, JORGE RODRIGO

 

MASSACHUSETTS GENERAL HOSPITAL

 

Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication

 

MUOTRI, ALYSSON R

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Modeling Autism with Human Pluripotent Cells

 

NAGRATH, SUNITHA

 

MASSACHUSETTS GENERAL HOSPITAL

 

Engineering Sensitive Microfluidic Multiplex Technology for Isolating Circulating

 

NANDA, VIKAS

 

UNIV OF MED/DENT NJ-R W JOHNSON MED SCH

 

Computational Design of a Synthetic Extracellular Matrix

 

ORDWAY, DIANE JOYCE.

 

COLORADO STATE UNIVERSITY-FORT COLLINS

 

Immune Modulation by Highly Virulent Clinical Isolates of M.TuberculosisARRA Logo

 

OZCAN, AYDOGAN

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Towards Mega-Throughput, Label-Free Genomics and Proteomics: Revolutionizing Micro-Arrays

 

PAYNE, CHRISTINE K

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Intracellular Delivery and Targeting of Nanoparticles

 

PENN, ANNA A

 

STANFORD UNIVERSITY

 

Fetal Brain Damage: A Placental Disorder

 

PURDON, PATRICK L

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia

 

QIAN, SHU-BING

 

CORNELL UNIVERSITY ITHACA

 

Engineering Ubiquitin Ligases to Investigate Protein Aggregation and Neurodegeneration

 

QIAN, WEI-JUN

 

BATTELLE PACIFIC NORTHWEST LABORATORIES A Universal Multiplex Assay System for High-Throughput Clinical Applications

 

REIJMERS, LEON

 

TUFTS UNIVERSITY BOSTON

 

Molecular Analysis of Functional Neural Circuits

 

REINEKE, THERESA M

 

VIRGINIA POLYTECHNIC INST AND ST UNIV

 

Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery

 

RINN, JOHN LOUIS

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

RNA and Chromatin Formation: From Discovery to Mechanism

 

SABETI, PARDIS CHRISTINE

 

HARVARD UNIVERSITY

 

Host and Pathogen Evolution in Lassa Fever

 

SAINT-GENIEZ, MAGALI

 

SCHEPENS EYE RESEARCH INSTITUTE

 

Bioengineering of Bruch's Membrane for the Treatment of Age-Related Macular Degeneration

 

SHOU, WENYING

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Cellular Cooperation and Cheating: An Experimental and Mathematical Analysis

 

SONNENBURG, JUSTIN

 

STANFORD UNIVERSITY

 

Discovery of Gut Microbiota-Targeted Small Molecules: New Tools and TherapeuticsARRA Logo

 

TAVAZOIE, SOHAIL F

 

ROCKEFELLER UNIVERSITY

 

The Discovery of microRNAs That Predict Chemotherapeutic Responsiveness of CancerARRA Logo

 

TIMLIN, JERILYN

 

SANDIA CORP-SANDIA NATIONAL LABORATORIES

 

Multiplexed Measurements of Protein Dynamics and Interactions at Extreme Resolution

 

TSO, CHO-LEA

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Cellular Quiescence and Brain Tumor Stem Cells

 

ULLIAN, ERIK M

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

The Role of Astrocytes in Plasticity and Disease

 

VEZYS, VAIVA D

 

UNIVERSITY OF MINNESOTA TWIN CITIES

 

Understanding the Persistence of Immune-Mediated Chronic Diseases

 

WEINBERGER, LEOR S

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Developing Transmissible Antivirals by Exploiting Gene-Expression CircuitryARRA Logo

 

ZHANG, CHUN-LI

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Neurogenesis De Novo in the Adult Central Nervous System

 

 

2008 NIH Director's New Innovator Award (DP2) - RFA-RM-08-014

PI Name Institution Name Title
BRYANT, ZEV

 

STANFORD UNIVERSITY

 

Engineering Molecular Motors

 

BUCKANOVICH, RONALD J

 

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

 

Using Embryonic Stem Cells to Re-Create a Human Tumor Microenvironment to Develop Ovarian Cancer Therapeutic and Diagnostic Tools

 

CARDOZO, TIMOTHY J

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Chemical Biology Design for Malaria

 

CHRISTMAN, KAREN L

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Engineering a Dynamic Extracellular Matrix Microenvironment

 

COBB, BRIAN A

 

CASE WESTERN RESERVE UNIVERSITY

 

T Cell Dependent Immune Responses to Carbohydrate Antigens

 

COHN, RONALD D

 

JOHNS HOPKINS UNIVERSITY

 

Maintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation

 

DUAN, XIANGFENG

 

UNIVERSITY OF CALIFORNIA, LOS ANGELES

 

Integrated Free-Standing Nanoprobes for Neuroscience and Beyond

 

FIELD, SETH J

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology

 

GITAI, ZEMER

 

PRINCETON UNIVERSITY

 

Discovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology

 

GITLER, AARON D

 

UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE

 

Using Yeast Cells to Define Mechanisms of Human Neurodegenerative Diseases

 

GRACIAS, DAVID H

 

JOHNS HOPKINS UNIVERSITY

 

Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine

 

HAYNES, CHRISTY L

 

UNIVERSITY OF MINNESOTA

 

Immune System-on-a-Chip for Quantitative Analysis of Cell Interactions during Allergy Response

 

KESLER, SHELLI R

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

Assessment and Treatment of Cognitive Deficits in Breast Cancer

 

KIRICHOK, YURIY

 

UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO

 

Molecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targets

 

KUMAR, SANJAY

 

UNIVERSITY OF CALIFORNIA, BERKELEY

 

Cellular Mechanobiology: Biophysics and Therapeutics

 

KUO, CHAY T

 

DUKE UNIVERSITY MEDICAL CENTER

 

Discovering Pathways Regulating Neurogenesis and Brain Remodeling after Injury

 

MAHAL, LARA K

 

UNIVERSITY OF TEXAS AT AUSTIN

 

An Integrated Systems Approach to Deconstructing Glycosylation

 

MURPHY, COLEEN TARA

 

PRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTE

 

Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators

 

NOMA, KENICHI

 

WISTAR INSTITUTE

 

A New Methodology to Decipher Three-Dimensional Genome Structure

 

OHI, MELANIE DIANE

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Multifaceted Approaches for Studying the Structure and Function of Spliceosomes

 

PFENNIG, KARIN S

 

UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL

 

The Origins and Maintenance of Context-Dependent Behavior

 

RAMALHO-SANTOS, MIGUEL

 

UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO

 

Role of Pluripotency in Development of the Germline

 

RECK-PETERSON, SAMARA L

 

HARVARD MEDICAL SCHOOL

 

Cellular Control of Microtubule-Based Transport: Unraveling Its Molecular Mechanism

 

SHAPIRO, ERIK

 

YALE UNIVERSITY SCHOOL OF MEDICINE

 

Single Cell MRI of Directed Cell Migration to Stroke

 

SHIH, WILLIAM M

 

DANA-FARBER CANCER INSTITUTE

 

NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes

 

WAGERS, AMY JO

 

JOSLIN DIABETES CENTER

 

Aging and Rejuvenation of the Hematopoietic Stem Cell Niche

 

WANG, JUE D

 

BAYLOR COLLEGE OF MEDICINE

 

The Molecular Interface of Replication Elongation and the Cellular Environment

 

WANG, LEI

 

SALK INSTITUTE OF BIOLOGICAL STUDIES

 

Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans

 

WU, JOSEPH C

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

Inducing Pluripotency with miRNAs: New Paradigm Shif in Cell Reprogramming

 

WU, SEAN M

 

MASSACHUSETTS GENERAL HOSPITAL

 

Generation of Functional Organs via Developmental Chimerism

 

ZEITLINGER, JULIA

 

STOWERS INSTITUTE FOR MEDICAL RESEARCH

 

Investigating Developmental Potential Based on Genome-Wide Chromatin Status

 

 

2007 NIH Director's New Innovator Award (DP2) - RFA-RM-07-009

PI Name Institution Name Title
AAGAARD-TILLERY, KJERSTI

 

BAYLOR COLLEGE OF MEDICINE

 

Characterization of the Fetal Primate Epigenome and Metabolome under In Utero Conditions of Maternal Obesity

 

BAILEY, RYAN

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays

 

BOYDEN, EDWARD

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Novel Tools and Principles for Precisely Controlling Brain Activity

 

CHAMPAGNE, FRANCES

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Epigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior

 

DAVIES, SEAN

 

VANDERBILT UNIVERSITY

 

Transformed Probiotic Bacteria for Treatment of Chronic Diseases

 

FERNANDEZ-FUNEZ, PEDRO

 

UNIVERSITY OF TEXAS MEDICAL BR GALVESTON

 

Mechanisms of Prion Misfolding

 

FORTUNE, SARAH

 

HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)

 

Variation in M. tuberculosis in Response to Host Selection

 

GARRAWAY, LEVI

 

DANA-FARBER CANCER INSTITUTE

 

Defining Melanoma Therapeutic Avenues by Integrative Functional Genomics

 

GUMBO, TAWANDA

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Efflux Pump Inhibitors to Reduce Duration of Antituberculosis Therapy

 

HACOHEN, NIR

 

MASSACHUSETTS GENERAL HOSPITAL

 

Revealing Pathogen-Sensing Pathways Using RNAi Libraries

 

HELDWEIN, EKATERINA

 

TUFTS UNIVERSITY BOSTON

 

Structural and Mechanistic Studies of Herpesvirus Entry into Host Cells

 

HOCHEDLINGER, KONRAD

 

MASSACHUSETTS GENERAL HOSPITAL

 

Reprogramming of Somatic Cells by Defined Factors

 

JACOBSON, KRISTEN

 

UNIVERSITY OF CHICAGO

 

From Neighborhoods to Neurons and Beyond

 

JANKOWSKY, JOANNA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Selective Neuronal Silencing to Study Cognitive Decline in Alzheimer's Disease

 

JASANOFF, ALAN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Genetically-Controlled MRI Contrast Agents for Functional Brain Imaging

 

JOHNSON, MARK

 

BRIGHAM AND WOMEN'S HOSPITAL

 

MicroRNA Biogenesis and the Cancer Proteome

 

LLINAS, MANUEL

 

PRINCETON UNIVERSITY

 

Novel Antimalarial Strategies Using Metabolomic Network Discovery

 

PAPA, FEROZ

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living Cells

 

PE'ER, DANA

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Genetic Variation and Regulatory Networks: Mechanisms and Complexity

 

PLATH, KATHRIN

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Chromatin and Epigenetic Inheritance

 

RAPE, MICHAEL

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Ubiquitin-Dependent Mechanisms of Tissue-Specific Cell Cycle Control

 

ROSENBLATT, JODY

 

UNIVERSITY OF UTAH

 

Identification of Signals that Extrude an Apoptotic Cell from an Epithelium

 

SAGHATELIAN, ALAN

 

HARVARD UNIVERSITY

 

Discovery Metabolite Profiling of the Prolyl Peptidases

 

SHORTER, JAMES

 

UNIVERSITY OF PENNSYLVANIA

 

Amyloid Elimination by Hsp104 and Substrate-Optimized Variants

 

SIPKINS, DOROTHY

 

UNIVERSITY OF CHICAGO

 

Stem Cell, Tumor and Bone Marrow Microenvironment Cross-Talk In Vivo

 

SPIEGEL, DAVID

 

YALE UNIVERSITY

 

Small-Molecule Antibody Recruiting Therapeutics for Treating Human Disease

 

SZIGETHY, EVA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness

 

TOOMRE, DEREK

 

YALE UNIVERSITY

 

Novel TIRF Microscopy for Analyzing Trafficking and Signaling at the Cell Cortex

 

YANG, JING

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Epithelial-Mesenchymal Transition in Tumor Metastasis

 

YANIK, MEHMET

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Development of On-Chip Ultra High-Throughput Whole-Animal Assay Technologies

 

This page last reviewed on February 22, 2023.

This page last reviewed on September 12, 2023