Program Snapshot
Part of the High-Risk, High-Reward Research program, the award supports early career investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the NIH mission.
- Single PI only
- Must have Early Stage Investigator status (completed doctoral degree or postgraduate clinical training within last 10 years and never received a substantial NIH independent research award)
- No preliminary data required
- Minimum of 25% research effort
- $475,000/year for 5 years
See the Award Overview for more information.

Applications due August 19, 2025