The goal of the Illuminating the Druggable Genome (IDG) Program is to improve our understanding of the properties and functions of proteins that are currently not well studied within commonly drug-targeted protein families. Currently, the pilot phase of the program is developing a website that integrates information about understudied proteins so that researchers everywhere can easily access it, catalyzing their own research and helping them find new proteins that may be of interest. In addition IDG is developing technologies to enable the study of understudied druggable proteins in a high throughput manner. The upcoming implementation phase of IDG aims to expand the informatics tools developed in the pilot phase, elucidate the function of understudied proteins from three key druggable protein families, and disseminate the IDG-generated resources to the greater scientific community.
Investigators in the IDG Consortium have Mapped Out the Targets of Every FDA Approved Drug. The IDG Knowledge Management Center has undertaken a comprehensive examination of the protein targets of all FDA approved drugs. Read more about the findings of this study.
Investigators from the Common Fund’s Illuminating the Druggable Genome program, used an innovative approach to uncover the function of orphan GPCRs. Read more.
IDG and KOMP2 Collaboration
The IDG Program is working closely with a complementary Common Fund effort, the Knockout Mouse Phenotyping (KOMP2) Program. By sharing information, IDG and KOMP2 will enhance the ability of both programs to prioritize genes of unknown function for study, and increase the pace and scientific depth of phenotyping studies, accelerating the discovery of biology that is relevant to health and disease.
Learn more about the IDG/KOMP2 collaboration.
For more information about the IDG program, contact the IDG Program Manager:
Jenna Baker, PhD | firstname.lastname@example.org.
IDG awardee Dr. Bryan Roth and colleagues develop a new method to study the potential interaction between proteins and other chemicals. The Roth lab published a recent study in the journal Nature Chemical Biology that highlighted how new computational methods can build upon previous IDG supported technology (PRESTO-Tango) to rapidly test if thousands of chemicals may alter different proteins’ function. This study used an understudied G-coupled protein receptor (GPCR) as a test case and found new chemicals that may help with side effects from opioid medication. By combining the speed of computational analysis with experimental evidence, the Roth lab hopes to help continue the success of the IDG program by learning more about understudied proteins and the small molecules they interact with. To find out more about this exciting research, read the full study here.
New research from IDG awardee Susumu Tomita and colleagues helps our understanding of how neurons work in the brain. A new research study published in the journal Neuron from the Tomita lab shows how certain proteins, termed GARLHs in the study, help move other proteins, called ion channels, which are important in neuronal signaling, to the correct location. Without these proteins interacting together, the signals between neurons in the brain would not work properly. This work highlights how the IDG program supports research that discovers unknown protein interactions to better our understanding of how proteins work. To find out more about how these proteins work, read the full study here.
IDG awardee Dr. Bryan Roth has been invited to give the 2017 Martin Rodbell Memorial Lecture sponsored by the National Institute of Environmental Health and Sciences on May 16, 2017. Dr. Roth's research focuses on increasing our capacity to find new drugs for relatively unknown proteins. Find out more about Dr. Roth's research by visiting his website. Stay tuned for more information about the lecture and congratulations Dr. Roth!
A technical assistance teleconference was held for potential applicants to these FOAs on December 13, 2016 at 3:30 PM EST. Click here to play a recording of this webinar.
As the user interface portal developed by the IDG, Pharos combines data on all human proteins from the over 100 data sources. Users are able to access, query, filter, and download any of this data from this portal. Learn how to use Pharos here.
Pharos: Collating protein information to shed light on the druggable genome. This article details the information that can be accessed through Pharos and describes how to use the portal.
More resources developed by the IDG program can be found here.