The goal of the Illuminating the Druggable Genome (IDG) Program is to improve our understanding of the properties and functions of proteins that are currently unannotated within the four most commonly drug-targeted protein families: the G-protein coupled receptors, nuclear receptors, ion channels, and protein kinases. Currently, the pilot program aims to create a data resource center, the Knowledge Management Center (KMC) that will catalog known information about the four protein families and obtain additional information about their function(s) so that investigators can determine whether a given protein is of interest. In this way, the KMC will be used to identify and prioritize unannotated proteins for further study.
IDG will develop and implement a public Web portal through which information can be transmitted to the broader community. The IDG program will also adapt and/or develop the technologies necessary to elucidate function within the four families of the druggable genome, if there is some indication that the function has relevance to disease.
Investigators from the Common Fund’s Illuminating the Druggable Genome program, used an innovative approach to uncover the function of orphan GPCRs. Read more.
IDG and KOMP2 Collaboration
The IDG Program is working closely with a complementary Common Fund effort, the Knockout Mouse Phenotyping (KOMP2) Program. By sharing information, IDG and KOMP2 will enhance the ability of both programs to prioritize genes of unknown function for study, and increase the pace and scientific depth of phenotyping studies, accelerating the discovery of biology that is relevant to health and disease.
Learn more about the IDG/KOMP2 collaboration.
NEW! PHAROS: the IDG User Interface Portal
Publications from IDG Investigators: Exploring the Druggable Genome
A recent paper published in Nature by IDG grantees Brian Shoichet and Bryan Roth, suggests combining physical and structure-based screening as a broadly useful method for ligand discovery of understudied and orphan GPCRs.
A recent article in Science Translational Medicine from IDG investigator Joel T. Dudley, demonstrates the usefulness of applying the precision medicine approach to characterize the complexity of Type 2 diabetes using high-dimensional electronic medical records and genotype data from over 11,000 patients.
NIH Director's Blog: Big Data Study Reveals Possible Subtypes of Type 2 Diabetes
An article published in Nature Structural and Molecular Biology describes PRESTO-Tango; a screening assay developed by Dr. Bryan L. Roth and colleagues at the University of North Carolina, Chapel Hill. PRESTO-Tango allows for the simultaneous investigation of every nonolfactory G protein-coupled receptor in the human genome. The methods and reagents developed are freely available to the scientific community.
Dr. Gary Johnson at the University of North Carolina, Chapel Hill published a paper in Cell Reports that used a global approach to study the effects of adaptation of the kinome (the full complement of human protein kinases) and its role in drug resistance during cancer treatment.
From the laboratory of Dr. Avi Ma'ayan
Search for genes and functional terms extracted and organized from over a hundred publicly available resources using the bioinformatics portal, Harmonizome and the Harmonizome mobile app.