The goal of the Illuminating the Druggable Genome (IDG) Program is to improve our understanding of the properties and functions of proteins that are currently unannotated within the four most commonly drug-targeted protein families: the G-protein coupled receptors, nuclear receptors, ion channels, and protein kinases. Currently, the pilot program aims to create a data resource center, the Knowledge Management Center (KMC) that will catalog known information about the four protein families and obtain additional information about their function(s) so that investigators can determine whether a given protein is of interest. In this way, the KMC will be used to identify and prioritize unannotated proteins for further study.
IDG will develop and implement a public Web portal through which information can be transmitted to the broader community. The IDG program will also adapt and/or develop the technologies necessary to elucidate function within the four families of the druggable genome, if there is some indication that the function has relevance to disease.
IDG and KOMP2 Collaboration
The IDG Program is working closely with a complementary Common Fund effort, the Knockout Mouse Phenotyping (KOMP2) Program. By sharing information, IDG and KOMP2 will enhance the ability of both programs to prioritize genes of unknown function for study, and increase the pace and scientific depth of phenotyping studies, accelerating the discovery of biology that is relevant to health and disease.
For more information about the IDG/KOMP2 collaboration click here.