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Funded Research

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-22-024
PI NameInstitution NameTitle
ALDINGER, KIMBERLY ANNESEATTLE CHILDREN'S HOSPITALDefining the MAST4 interactome in brain development and epilepsy
BHATNAGAR, SUSHANT (contact)
KIMPLE, MICHELLE E
UNIVERSITY OF ALABAMA AT BIRMINGHAMInvestigating the Effects of ADGRB3 Signaling on Incretin-Mediated Insulin Secretion from Pancreatic Beta-Cells
BRASCH, JULIAUNIVERSITY OF UTAHStructural and functional characterization of synaptic adhesion GPCR ADGRB3 binding interactions
CALDWELL, KIM AUNIVERSITY OF ALABAMA IN TUSCALOOSAFunctional analysis of KCNK12 in dopaminergic neuroprotection
CHEN, RONGWAKE FOREST UNIVERSITY HEALTH SCIENCESIllumination of TAAR2 Location, Function and Regulators
CHOI, SUYONGUNIVERSITY OF NEBRASKA MEDICAL CENTERPIP5K1A is a novel mutant KRAS effector and essential for pancreatic cancer cell survival
COETZEE, WILLIAM A (contact)
FESKE, STEFAN
NEW YORK UNIVERSITY SCHOOL OF MEDICINETweety proteins: their roles in pericytes and macrophages
CUELLO, LUIS GONZALOTEXAS TECH UNIVERSITY HEALTH SCIS CENTERUtilizing the power of synthetic biology and De Novo design for the overexpression and biochemical stabilization of KCNA6 or Kv1.6 potassium channels in the E. coli expression system
CUI, TAIXINGUNIVERSITY OF SOUTH CAROLINA AT COLUMBIACyclin-dependent kinase (CDK)19-mediated vein graft intimal hyperplasia
GARCIA, VICTORNEW YORK MEDICAL COLLEGEUncovering the role of GPR75 as an activator of fatty acid transporters in non-alcoholic fatty liver disease (NAFLD)
GELMANN, EDWARD PUNIVERSITY OF ARIZONADYRK1B Inhibition for Prostate Cancer
KANT, SHASHIBRIGHAM AND WOMEN'S HOSPITALMixed Lineage Kinase 2 (MLK2) and vascular homeostasis
KEMP, CHRISTOPHER JFRED HUTCHINSON CANCER CENTERMechanisms of Pip4k2c and Pip5k1b dependencies in Ras driven squamous cell carcinoma
RESSL, SUSANNEUNIVERSITY OF TEXAS AT AUSTINThe biophysical basis of the ADGRB3 extra-cellular interaction network.
SATO, PRISCILADREXEL UNIVERSITYDeciphering a novel kinase function for adck2 in the heart
SCHURER, STEPHAN CUNIVERSITY OF MIAMI SCHOOL OF MEDICINEElucidating the Understudied Kinase PNCK as a Prospective Drug Target in Renal Cell Carcinoma
TANIS, JESSICA EUNIVERSITY OF DELAWAREImpact of PIP5K1 on extracellular vesicle biogenesis
TERENTYEV, DMITRY AOHIO STATE UNIVERSITYDefining the role of KCNN1 in atrial arrhythmias
VETTER, STEFAN WNORTH DAKOTA STATE UNIVERSITYBiochemical Characterization of the CAMKV Pseudokinase
WEIS, WILLIAM ISTANFORD UNIVERSITYNanobody- and mini-G protein-enabled molecular pharmacology of HCAR1
WONG, CHING-ONRUTGERS THE STATE UNIV OF NJ NEWARKThe role of TTYH1 in glial cell autophagy

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-21-012
PI NameInstitution NameTitle
CAO, ERHUUNIVERSITY OF UTAHDevelop enabling biochemical and structural tools for dissecting the roles of PKD2L2 in metabolism
DELLING, MARKUS GUNIVERSITY OF CALIFORNIA, SAN FRANCISCOFunctional characterization of the dark matter ion channel polycystin2-like2
FESKE, STEFAN (contact) 
COETZEE, WILLIAM A
NEW YORK UNIVERSITY SCHOOL OF MEDICINEFAM26F function and role in macrophages
JACKSON, PETER KENTSTANFORD UNIVERSITYUnderstudied GPCRs connecting signaling in primary cilia to obesity and metabolic disease
KHAN, MOHD NAZIREMORY UNIVERSITYTargeting GPR68 as a novel modulator of osteoarthritis
KU, GREGORY MICHAELUNIVERSITY OF CALIFORNIA, SAN FRANCISCOCreating a mouse and human model of a novel monogenic diabetes syndrome
MA, ZHENGYUALFRED I. DU PONT HOSP FOR CHILDRENIdentify cell surface protein ligand candidates for understudied adhesion GPCRs using a sensitive cell-based approach
NAKAGAWA, TERUNAGAVANDERBILT UNIVERSITYIlluminating the structure and function of CACNG5 and 7
ORLANDI, CESAREUNIVERSITY OF ROCHESTEROrphan Receptor Gprc5b in Retinoic Acid-induced Affective Behaviors
PROBER, DAVID AARON (contact) 
CHOU, TSUI-FEN 
CALIFORNIA INSTITUTE OF TECHNOLOGYPhosphoproteomic Analyses of Understudied Protein Kinases that affect Zebrafish Sleep
SACK, JON THOMAS (contact)
FERNS, MICHAEL J     
UNIVERSITY OF CALIFORNIA AT DAVIS Generation of tools for visualizing understudied KvS potassium channel proteins
SHEPARD, BLYTHE D GEORGETOWN UNIVERSITYHepatic GPR125: ligands and liver repair
SINGH, HARPREETOHIO STATE UNIVERSITYBiophysical properties and role of CLIC6 in cardiomyocyte mitochondria
THYME, SUMMER BUNIVERSITY OF ALABAMA AT BIRMINGHAMRole of VRK2 Kinase in Brain Development and Function
TOWLER, DWIGHT AUT SOUTHWESTERN MEDICAL CENTERCdc42bpg signaling in arteriosclerosis and vascular fibrosis
TURK, BENJAMIN EYALE UNIVERSITYDefining protein interaction networks involving the atypical MAP kinases ERK4 and ERK7
WANG, BIAOUNIVERSITY OF CALIFORNIA, SAN FRANCISCOTSSK-dependent signaling pathway in spermatogenesis
YOUNG, SAMUEL MATTHEWUNIVERSITY OF IOWAElucidating the roles of CACNA2D2 and CACNA2D3 in presynaptic regulation of mammalian synaptic function
YU, EUGENE ROSWELL PARK CANCER INSTITUTE CORPCRISPR-mediated engineering and pilot study of mouse mutants of the bitter taste receptor genes
ZAGOTTA, WILLIAM NUNIVERSITY OF WASHINGTONFunctional and structural dynamics of KCNH4 and KCNH8

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-21-020
PI NameInstitution NameTitle
KANNAN, NATARAJAN (contact)
LU, WEI.
UNIVERSITY OF GEORGIAAnnotating dark ion-channel functions using evolutionary features, machine learning and knowledge graph mining
PANDEY, GAURAV (contact)
SCHLESSINGER, AVNER
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIMulti-modal data integration to identify kinase substrates
ZHANG, BINGBAYLOR COLLEGE OF MEDICINEIlluminating understudied druggable proteins using pan-cancer proteogenomics data

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-20-019
PI NameInstitution NameTitle
BANERJEE, PRIYA RSTATE UNIVERSITY OF NEW YORK AT BUFFALODeciphering the role of low complexity domains in dual specificity kinase function
BOBECK, ERIN NICOLEUTAH STATE UNIVERSITYGPR171 As a Novel Target to Treat Neuropathic Pain
BRETT, THOMAS JOHNWASHINGTON UNIVERSITYIlluminating the role of chloride channel regulator CLCA4 in TMEM16 Family potentiation and disease
CARON, KATHLEEN MUNIV OF NORTH CAROLINA CHAPEL HILLIlluminating Orphan GPCRs in Lymphatics
CHANG, GEOFFREY A (contact) 
INSEL, PAUL A 
UNIVERSITY OF CALIFORNIA, SAN DIEGONanobody inhibitors of proton-sensing G protein-coupled receptors
COLECRAFT, HENRY MCOLUMBIA UNIVERSITY HEALTH SCIENCESNanobodies for Probing CACNA2D2 and CACNA2D3 Function, Expression, and Therapeutics
GAUTRON, LAURENTUT SOUTHWESTERN MEDICAL CENTERNeuronal GPR149 and energy homeostasis
GERBER, SCOTT ADARTMOUTH COLLEGEProteomics approaches for illuminating the functions of the dark kinases Nek6, Nek7 & Nek9
GRUETER, CHAD EUNIVERSITY OF IOWACdk19-dependent transcriptional mechanisms in cardiac hypertrophy
HAMMOND, GERALD RUNIVERSITY OF PITTSBURGH AT PITTSBURGHPIP5K1A as a novel driver of PI3K signaling in health and disease
KHOR, BERNARDBENAROYA RESEARCH INST AT VIRGINIA MASONIlluminating a novel role of understudied DYRKs in anti-inflammatory T cell differentiation
LEE, SUN JOOWASHINGTON UNIVERSITYStructure/function analysis of understudied pH-sensitive Kir4.2 channels in vitro with conformation specific nanobodies
MACLEAN, DAVID MALCOMUNIVERSITY OF ROCHESTERGenetic code expansion and the study of CACNG proteins
MAIERS, JESSICA LMAYO CLINIC ROCHESTERIdentifying targetable mechanisms of TMEM38B/TRIC-B in liver fibrosis
MYERS, BENJAMINUNIVERSITY OF UTAHIlluminating Druggable Targets via Interrogation of Direct GPCR-kinase Interactions
NAIRN, ANGUS CYALE UNIVERSITYRole of MAST3 kinase in developmental and epileptic encephalopathy
PABLA, NAVJOTOHIO STATE UNIVERSITYIlluminating the biological functions of CDKL1 Kinase
REITER, JEREMY FUNIVERSITY OF CALIFORNIA, SAN FRANCISCOIlluminating the function of the understudied kinase DYRK2 in ciliary Hedgehog signal transduction
SANTY, LORRAINE CPENNSYLVANIA STATE UNIVERSITY-UNIV PARKIdentifying endosomal Phosphatidylinositol 4-phosphate 5-kinase isoforms regulating growth factor stimulated integrin recycling and migration
SUTTON, LAURIEUNIVERSITY OF MARYLAND BALT CO CAMPUSInvestigating the role of GPR162 in hedonic behaviors
TRAYNELIS, STEPHEN FEMORY UNIVERSITYGenetic analysis to determine the functional role of GRID1
VARSHNEY, GAURAV KOKLAHOMA MEDICAL RESEARCH FOUNDATIONFunctional characterization of understudied protein kinases implicated in developmental disorders using zebrafish
WANDINGER-NESS, ANGELA (contact) 
HUDSON, LAURIE G
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTRIlluminating the functions and translational potential of CDC42BP/MRCK kinases in ovarian cancer
ZHANG, CHENGUNIVERSITY OF PITTSBURGH AT PITTSBURGHStructure and pharmacology of GPR32 in the resolution of inflammation

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-19-011
PI NameInstitution NameTitle
BUROW, MATTHEW E. (contact) 
DREWRY, DAVID HAROLD
TULANE UNIVERSITY OF LOUISIANACharacterization of an understudied kinase, NEK5, in acquisition of a mesenchymal and migratory cell
FOSKETT, JAMES KEVINUNIVERSITY OF PENNSYLVANIAIdentification of CALHM proteins as ion channels
GLIMCHER, LAURIE HOLLISDANA-FARBER CANCER INSTMulti-faceted Roles of an Atypical Kinase RIOK2 in Erythropoiesis and Myelodyplastic Syndromes
GOETZ, SARAHDUKE UNIVERSITYDefining biochemical mechanisms of dominant interference by disease-causing variants of TTBK2
GOLKOWSKI, MARTINUNIVERSITY OF WASHINGTONTargeting understudied kinases in cancer cell plasticity and drug resistance
HAHN, WILLIAM CDANA-FARBER CANCER INSTNovel genetic dependencies in VRK2 methylated glioblastoma multiforme
JIN, CHUNYANG (contact) 
HESK, DAVID
RESEARCH TRIANGLE INSTITUTEPreparation and characterization of radioligands for the orphan receptor GPR88
JO, YOUNG-HWANALBERT EINSTEIN COLLEGE OF MEDICINERole of HCAR1 in glucose homeostasis
JURA, NATALIAUNIVERSITY OF CALIFORNIA, SAN FRANCISCOStructural and functional investigation of the understudied HIPK1 kinase
MANGLIK, AASHISHUNIVERSITY OF CALIFORNIA, SAN FRANCISCOBiochemical approaches to enlighten GPR85 function
MARTINELLI, DAVID CHRISTOPHERUNIVERSITY OF CONNECTICUT SCH OF MED/DNTDetermination of the subcellular localization of adhesion G protein-coupled receptor B3 (ADGRB3) and its locations of interaction with secreted C1Q-like ligands 
NGUYEN, THUYRESEARCH TRIANGLE INSTITUTEDevelopment of Novel Neuropeptide B/W Receptor 1 Agonists
PHILIPS, MARK REIDNEW YORK UNIVERSITY SCHOOL OF MEDICINERegulation of KRAS Trafficking and Signaling by GPR31
REN, HONGXIA (contact) 
WATTS, VAL J
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLISIlluminating the Metabolic Function of GPR162 by Delineating Downstream Signaling Pathways and Characterizing Hypothalamic Expression Pattern
SODEN, MARTA E   UNIVERSITY OF WASHINGTONTargeted mutagenesis to elucidate the function of understudied ion channels in the central nervous system 
TERSEY, SARAH A. (contact) 
MIRMIRA, RAGHAVENDRA G
UNIVERSITY OF CHICAGOThe 12-HETE receptor Gpr31 in the β-cell pathogenesis of type 1 diabetes
TSAI, NIEN-PEIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNStudy of PAK3 in epilepsy-associated defects in synaptic plasticity

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-18-021
PI NameInstitution NameTitle
ARAC-OZKAN, DEMETUNIVERSITY OF CHICAGOStructural and Functional Studies of Brain Angiogenesis Inhibitors (BAIs/ADGRBs)
CHAHROUR, MARIAUT SOUTHWESTERN MEDICAL CENTERInvestigating the role of BCKDK in neurodevelopmental disorders through a novel mouse model
DEVI, LAKSHMI AICAHN SCHOOL OF MEDICINE AT MOUNT SINAITargeted Deorphanization of G Protein-Coupled Receptors
FESKE, STEFANNEW YORK UNIVERSITY SCHOOL OF MEDICINECalcium channel CACNB1 in T cell function and immunity
GREEN, THOMAS ARTHUR (contact)
LAEZZA, FERNANDA
UNIVERSITY OF TEXAS MED BR GALVESTONGpr12: a novel factor for addiction and mental health
ISOM, DANIELUNIVERSITY OF MIAMI SCHOOL OF MEDICINENew CRISPR-based technologies for screening dark GPCRs
KU, GREGORY MICHAELUNIVERSITY OF CALIFORNIA, SAN FRANCISCOUncovering Two Novel Diabetes Drug Targets in the IDG
LEE, AMYUNIVERSITY OF IOWAIlluminating the functions of CACNA2D4 in the brain
LODMELL, J STEPHENUNIVERSITY OF MONTANARole of the atypical protein kinase RIOK3 in the cellular antiviral response
MARTO, JARROD ADANA-FARBER CANCER INSTTools for the understudied kinase PNK3
NEWTON, ALEXANDRA CUNIVERSITY OF CALIFORNIA, SAN DIEGOEstablishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
SEBAG, JULIEN ALBERTUNIVERSITY OF IOWAIdentification of the central localization and regulation of the Prokineticin 1 Receptor, a novel target for the treatment of obesity
TAYLOR, SUSAN SUNIVERSITY OF CALIFORNIA, SAN DIEGOIlluminating the Role of understudied PRKACB Splice Variants in PKA Signaling
TURK, BENJAMIN E (contact)
CALDERWOOD, DAVID A
YALE UNIVERSITYInteraction of substrates and inhibitors with tousled-like kinase 2
WHIM, MATTHEWLSU HEALTH SCIENCES CENTERDetermining the role of the adrenal Y2 and Y5 receptors in the prevention of hypoglycemia
WHITEHURST, ANGELIQUE WRIGHTUT SOUTHWESTERN MEDICAL CENTERMechanisms and Models of Testis Specific Serine Kinase 6 (TSSK6)

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-18-011
PI NameInstitution NameTitle
KANNAN, NATARAJAN (contact)
KOCHUT, KRZYSZTOF J.
UNIVERSITY OF GEORGIAA data analytics framework for mining the dark kinome
ROBINSON, PETER NICHOLAS (contact)
MUNGALL, CHRISTOPHER J
OPREA, TUDOR I
JACKSON LABORATORYIlluminating the Druggable Genome by Knowledge Graphs
WU, GUANMING (contact)
DEUSTACHIO, PETER G
STEIN, LINCOLN D.
OREGON HEALTH & SCIENCE UNIVERSITYReactome IDG portal: Pathway-based analysis and visualization of understudied human proteins

 

Knowledge Management Center for Illuminating the Druggable Genome (U24) RFA-RM-16-024
PI NameInstitution NameTitle
MA'AYAN, AVIICAHN SCHOOL OF MEDICINE AT MOUNT SINAIKnowledge Management Center for Illuminating the Druggable Genome (Component Award)
OPREA, TUDOR IUNIVERSITY OF NEW MEXICO HEALTH SCIS CTRKnowledge Management Center for Illuminating the Druggable Genome (Center Award)

 

Data and Resource Generation Centers for Illuminating the Druggable Genome (U24) RFA-RM-16-026
PI NameInstitution NameTitle
JOHNSON, GARY LUNIV OF NORTH CAROLINA CHAPEL HILLIlluminating Function of the Understudied Druggable Kinome
MCMANUS, MICHAEL T (contact) 
JAN, LILY Y
UNIVERSITY OF CALIFORNIA, SAN FRANCISCOIlluminating Druggable Dark Matter
ROTH, BRYAN L. (contact) 
SHOICHET, BRIAN K
UNIV OF NORTH CAROLINA CHAPEL HILLIlluminating the druggable GPCR-ome

 

Resource Dissemination and Outreach Center for Illuminating the Druggable Genome (U24) RFA-RM-16-025
PI NameInstitution NameTitle
SCHÜRER, STEPHAN C (contact) 
OPREA, TUDOR I 
SKLAR, LARRY A. 
UNIVERSITY OF MIAMI SCHOOL OF MEDICINEIlluminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)

 

Development of a Knowledge Management Center for Illuminating the Druggable GenomeTitle Here (U54) RFA-RM-13-011
PI NameInstitution NameTitle
MA'AYAN, AVIICAHN SCHOOL OF MEDICINE AT MOUNT SINAIMount Sinais Knowledge Management Center for Illuminating the Druggable Genome
OPREA, TUDOR IUNIVERSITY OF NEW MEXICO HEALTH SCIS CTRIlluminating the Druggable Genome Knowledge Management Center (IDG KMC)

 

Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) RFA-RM-13-010
PI NameInstitution NameTitle
FINKBEINER, STEVEN M.J. DAVID GLADSTONE INSTITUTESPhysical Exam of Human Neurons to Identify Functions of the Druggable Genome
JOHNSON, GARY L.UNIV OF NORTH CAROLINA CHAPEL HILLActivation and Regulation of the Understudied Kinome Using MIB/MS Technology
MCMANUS, MICHAEL T.UNIVERSITY OF CALIFORNIA, SAN FRANCISCOUnlocking the Hidden Kinome
QIN, JUNBAYLOR COLLEGE OF MEDICINESignaling Networks of Nuclear Receptor Transcriptional Crosstalk in Lung Cancer
ROTH, BRYAN L (contact)
SHOICHET, BRIAN K.
UNIV OF NORTH CAROLINA CHAPEL HILLScalable technologies for illuminating the druggable GPCR-ome
TOMITA, SUSUMUYALE UNIVERSITYIdentify functional modulators of ionotropic neurotransmitter receptors in brain
YEH, JING-RUEY JOANNA (contact)
KOKEL, DAVID
MASSACHUSETTS GENERAL HOSPITALScalable in vivo tools for annotating and manipulating the druggable genome

 

This page last reviewed on March 14, 2024