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Extracellular RNA Communication

Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-028

In September 2021, the awards below transitioned into their UH3 phase. The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on demonstrating isolation effectiveness using human biofluids.
PI Name	Institution Name	Title
CHIU, DANIEL T	UNIVERSITY OF WASHINGTON	Single Extracellular Vesicle Sorting and Analysis
DAS, SAUMYA (contact) TALISMAN, TIJANA VAN KEUREN-JENSEN, KENDALL	MASSACHUSETTS GENERAL HOSPITAL	Molecular dissection and imaging of extracellular vesicles to define their origin and targets
GHIRAN, IONITA CALIN (contact) JONES, JENNIFER MILOSAVLJEVIC, ALEKSANDAR	BETH ISRAEL DEACONESS MEDICAL CENTER	Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry
REATEGUI, EDUARDO (contact) KIM, YON SON BETTY	OHIO STATE UNIVERSITY	Microfluidics Array Based Sorting, Isolation, and RNA Analysis in Single Extracellular V csicles
ROUTENBERG, DAVID AARON	MESO SCALE DIAGNOSTICS, LLC	Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures
WONG, DAVID T (contact) HUANG, TONY JUN KIM, SUNG KIM, YONG XIE, YA-HONG	UNIVERSITY OF CALIFORNIA LOS ANGELES	Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids

**Advancing Extracellular RNA (exRNA) Communication Research: Improved Isolation and Analysis of exRNA-Carrier Subclasses (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-027**

In September 2021, the awards below transitioned into their UH3 phase. The UG3 phase (first phase) of these awards focused on technology development and feasibility, while the UG3 phase will focus on UH3 optimizing, refining, and scaling-up of validated separation technologies using human biofluids.
CHANG, HSUEH-CHIA	UNIVERSITY OF NOTRE DAME	High-Throughput Electrokinetic Fractionation and Analysis of Extracellular RNA Nano-Carriers
COFFEY, ROBERT J. (contact) CHAREST, ALAIN	VANDERBILT UNIVERSITY MEDICAL CENTER	Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma
LAURENT, LOUISE CHANG	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargo
RAFFAI, ROBERT (contact) MATEESCU, BOGDAN VAN KEUREN-JENSEN, KENDALL	NORTHERN CALIFORNIA INSTITUTE/RES/EDU	P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using Microfluidic
WITWER, KENNETH W	JOHNS HOPKINS UNIVERSITY	Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates

**Data Management and Resource Repository (DMRR) on Extracellular RNA (U54 Clinical Trial Not Allowed) RFA-RM-18-026**
PI Name	Institution Name	Title
MILOSAVLJEVIC, ALEKSANDAR (contact) GALAS, DAVID J. GERSTEIN, MARK BENDER	BAYLOR COLLEGE OF MEDICINE	DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE EXRNA ATLAS PHASE II

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-18-648
PI Name	Institution Name	Title
HERMANN, THOMAS C	UNIVERSITY OF CALIFORNIA, SAN DIEGO	2019 RNA Nanotechnology GRC/GRS

**Clinical Utility of Extracellular RNA for Biomarker Development (UH2/UH3) RFA-RM-12-013**
In 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the biomarkers.
PI Name	Institution Name	Title
CARTER, BOB S (contact) HOCHBERG, FRED H	UNIVERSITY OF CALIFORNIA SAN DIEGO	exRNA Biomarkers for Human Glioma
DAS, SAUMYA (contact) KWONG, RAYMOND Y ROSENZWEIG, ANTHONY SABATINE, MARC S	BETH ISRAEL DEACONESS MEDICAL CENTER	Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI
FREEDMAN, JANE E	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
JENSEN, KENDALL(contact) ADELSON, P. DAVID HUENTELMAN, MATTHEW KALANI, YASHAR	TRANSLATIONAL GENOMICS RESEARCH INST	exRNA signatures Predict Outcomes after brain injury
LAURENT, LOUISE C	UNIVERSITY OF CALIFORNIA SAN DIEGO	ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction
PATEL, TUSHAR	MAYO CLINIC JACKSONVILLE	Extracellular non-coding RNA biomarkers of hepatocellular cancer
SAUGSTAD, JULIE ANNE (contact) QUINN, JOSEPH F	OREGON HEALTH AND SCI UNIVERSITY	Clinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimers Disease
TUSCHL, THOMAS (contact) SUTHANTHIRAN, MANIKKAM	ROCKEFELLER UNIVERSITY	Clinical utility of extracellular RNA as marker of kidney disease progression
WEINER, HOWARD L	BRIGHAM AND WOMEN'S HOSPITAL	Circulating MicroRNAs as Disease Biomarkers in Multiple Sclerosis
WONG, DAVID T	UNIVERSITY OF CALIFORNIA LOS ANGELES	Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection

**Clinical Utility of Extracellular RNA for Therapy Development (UH2/UH3) RFA-RM-12-014**
In August 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the therapeutics.
PI Name	Institution Name	Title
ABDEL-MAGEED, ASIM, B	TULANE UNIVERSITY OF LOUISIANA	Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni
ARONIN, NEIL	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Exosome based therapeutics in Huntingtons disease
KRAIG, RICHARD P	UNIVERSITY OF CHICAGO	Exosome RNA-Therapeutics to Promote CNS Myelination
MATIN, AC	STANFORD UNIVERSITY	HER2-targeted exosomal delivery of therapeutic mRNA for enzyme pro-drug therapy
QUESENBERRY, PETER J	RHODE ISLAND HOSPITAL	Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN
SCHMITTGEN, THOMAS D (contact) PHELPS, MITCH A	UNIVERSITY OF FLORIDA	Targeted delivery of microRNA-loaded microvesicle for cancer therapy
SOOD, ANIL K (contact) CALIN, GEORGE A LOPEZ-BERESTEIN, GABRIEL	UT MD ANDERSON CANCER CTR	Novel extra cellular RNA-based combinatorial RNA inhibition therapy
ZHANG, HUANG-GE (contact) GUO, PEIXUAN	UNIVERSITY OF LOUISVILLE	Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs

**NIH Support for Conferences and Scientific Meetings (Parent R13/U13) PA-13-347**
PI Name	Institution Name	Title
GUO, PEIXUAN	GORDON RESEARCH CONFERENCES	2 015 RNA Nanotechnology Gordon Research Conference
QUESENBERRY, PETER J	GORDON RESEARCH CONFERENCES	2016 Extracellular Vesicles Gordon Research Conference
WITWER, KENNETH W	JOHNS HOPKINS UNIVERSITY	International Society for Extracellular Vesicles - Education Day & Meeting
WOODLAND, DAVID L.	KEYSTONE CONFERENCE CENTER	Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication

**Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA (U01) RFA-RM-13-014**
PI Name	Institution Name	Title
FREEDMAN, JANE E (contact) GERSTEIN, MARK BENDER MUKAMAL, KENNETH JAY ODONNELL, CHRISTOPHER J	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Racial and Ethnic Diversity in Human Extracellular RNA
GALAS, DAVID J. (contact) NICKERSON, DEBORAH A WANG, KAI	PACIFIC NORTHWEST RESEARCH INSTITUTE	Reference Profiles of Extracellular RNA in 4 Body Fluids of Healthy Humans
GHIRAN, IONITA CALIN	BETH ISRAEL DEACONESS MEDICAL CENTER	Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy in healthy individuals
LAURENT, LOUISE C	UNIVERSITY OF CALIFORNIA SAN DIEGO	Reference Profiles of ExRNAs in Normal Human Pregnancy
TEWARI, MUNEESH	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Reference Profiles of ExRNA in Biofluids from Well-Defined Human Cohorts
WOODRUFF, PRESCOTT G (contact) ERLE, DAVID J	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA

**Data Management and Resource Repository (DMRR) on Extracellular RNA (U54) RFA-RM-12-010**
PI Name	Institution Name	Title
MILOSAVLJEVIC, ALEKSANDAR (contact) GALAS, DAVID J. GERSTEIN, MARK BENDER	BAYLOR COLLEGE OF MEDICINE	Data management and Resource Repository for the exRNA Atlas

**Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function (U19) RFA-RM-12-012**
PI Name	Institution Name	Title
BLELLOCH, ROBERT H	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	In Vivo Regulated Release and Function of Extracellular Small RNAs
BREAKEFIELD, XANDRA OWENS (contact) CHAREST, ALAIN GOULD, STEPHEN J KRICHEVSKY, ANNA M. MEMPEL, THORSTEN ROMAN	MASSACHUSETTS GENERAL HOSP	exRNA released by glioblastoma alters brain microenvironment
COFFEY, ROBERT J.	VANDERBILT UNIVERSITY MED CTR	Secreted RNA during CRC progression biogenesis function and clinical markers
MCMANUS, MICHAEL T	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	Genetic models for exRNA communication
TUSCHL, THOMAS	ROCKEFELLER UNIVERSITY	Definition of Serum Ribonucleoprotein Composition and its Regulation and Function

This page last reviewed on October 26, 2021

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