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Funded Research

The Molecular Libraries and Imaging program has transitioned from Common Fund support. For more information, please visit https://commonfund.nih.gov/molecularlibraries/index. Please note that since the Molecular Libraries and Imaging program is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis. 

Molecular Libraries Screening Centers and Small Molecule Repository

Molecular Libraries Probe Production Centers Network (MLPCN) (U54) – Limited Competition
RFA-RM-08-005
PI NameInstitution NameTitle
AUBE, JEFFREYUNIVERSITY OF KANSASUniversity of Kansas Specialized Chemistry Center
JACKSON, MICHAELSANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCHBurnham Center for Chemical Genomics
JONSSON, COLLEENSOUTHERN RESEARCH INSTITUTESouthern Research Specialized Biocontainment Screening Center (SRSBSC)
LI, MINJOHNS HOPKINS UNIVERSITYJohns Hopkins Ion Channel Center
LINDSLEY, CRAIGVANDERBILT UNIVERSITYThe Vanderbilt Specialized Chemistry Center for Accelerated Probe Development
ROSEN, HUGHTHE SCRIPPS RESEARCH INSTITUTEThe Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps
SCHREIBER, STUARTBROAD INSTITUTEBroad Institute Comprehensive Screening Center
SIMEONOV, ANTONNCATSNIH Chemical Genomics Center
SKLAR, LARRYUNIVERSITY OF NEW MEXICOUniversity of New Mexico Center for Molecular Discovery

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Molecular Libraries Screening Centers Network (MLSCN)#
RFA-RM-04-017
PI NameInstitution NameTitle
AUSTIN, CHRISU.S. NATIONAL HUMAN GENOME RESEARCH INST

NIH Chemical Genomics Center (NCGC)

DIAMOND, SCOTTUNIVERSITY OF PENNSYLVANIA

The Penn Center for Molecular Discovery

DINGLEDINE, RAYMONDEMORY UNIVERSITYEmory Chemistry-Biology Center in the MLSCN
LAZO, JOHNUNIVERSITY OF PITTSBURGH AT PITTSBURGHUniversity of Pittsburgh Molecular Libraries Screening Center
PIAZZA, GARYSOUTHERN RESEARCH INSTITUTESouthern Research Molecular Libraries Screening Center
REED, JOHNTHE BURNHAM INSTITUTESan Diego Center for Chemical Genomics
ROSEN, HUGHTHE SCRIPPS RESEARCH INSTITUTEScripps Research Institute Molecular Screen Center(RMI)
ROTHMAN, JAMESCOLUMBIA UNIVERSITY MEDICAL CENTERMLSCN Center at Columbia University
SKLAR, LARRYUNIVERSITY OF NEW MEXICO ALBUQUERQUE

New Mexico Molecular Libraries Screening Center

WEAVER, C. DAVIDVANDERBILT UNIVERSITY

Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters

Special Terms and Conditions of Roles and Responsibilities Standard to Each Screening Center (PDF, 6 pages)

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CONTRACTS
PI NameInstitution NameTitle
LIVINGSTON, DOUGBIOFOCUS DPI, A GALAPAGOS COMPANYMolecular Libraries Small Molecule Repository

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)
PAR-09-129
PI NameInstitution NameTitle
ADHIKARI, SANJAYGEORGETOWN UNIVERSITYScreening of inhibitors for human 5-prime-tyrosyl DNA phosphodiesterase (hTDP2)
ALDRICH, COURTNEY CUNIVERSITY OF MINNESOTA TWIN CITIESA fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis
ALTSHULER, DAVIDMASSACHUSETTS GENERAL HOSPITALIdentifying the Molecular Pathways Regulating Glucose-dependent Insulin Secretion
ARNER, ELIAS S.J.KAROLINSKA INSTITUTEHTS FOR DRUGS TARGETING THE MAMMALIAN SELENOPROTEIN THIOREDOXIN REDUCTASE 1
ARNOLD, ALEXANDERUNIVERSITY OF WISCONSIN MILWAUKEESmall molecule inhibitors of the vitamin D receptor-coactivator interaction
ATKINS, JOHN F.UNIVERSITY OF UTAHHigh Throughput Screening for Foot and Mouth Disease Virus Antivirals
BARAK, LAWRENCE S.DUKE UNIVERSITYSmall Molecule Agonsists for the Neurotensin 1 Receptor
BARROW, JAMES (contact)
FERRER, MARC
WEINBERGER, DANIEL
LIEBER INSTITUTE, INC.High Throughput Screening for Specific Inhibitors and Modulators of A Novel Potas
BASSLER, BONNIE LPRINCETON UNIVERSITYA High-Throughput Screen for Modulators of Quorum Sensing in Vibrio cholerae
BERTHELSEN, JENSUNIVERSITY OF COPENHAGENSmall-molecule inhibitors of hADAM12
BISHAI, WILLIAM RAMSESJOHNS HOPKINS UNIVERSITYScreen for Synthetic lethality in Mycobacterium Tuberculosis
BISWAL, SHYAMJOHNS HOPKINS UNIVERSITYDevelopment of inlammasome inhibitors to be used as anti-inflammatory agents
BOTTINI, NUNZIOLA JOLLA INST FOR ALLERGY & IMMUNOLGYSmall molecule inhibitors of LMPTP: an obesity drug target
BROSH, ROBERT M (contact)
BOHR, VILHELM A
U.S. NATIONAL INSTITUTE ON AGINGHigh Throughput Screening to Identify Inhibitors of the WRN Syndrome Helicase
CANNON, RICHARD DUNIVERSITY OF OTAGOIdentification of Broad-spectrum Antifungal Efflux Pump Inhibitors
CAULFIELD, MICHAEL JINTERNATIONAL AIDS VACCINE INITIATIVEScreening for HIV-1 envelope mimetics from small molecule libraries
CHEN, JAMES KSTANFORD UNIVERSITYA high-throughput screen for small-molecule antagonists of Gli function
CHUNG,DONGHOONUNIVERSITY OF LOUISVILLEA Cell-based HTS to discover molecules that inhibit VEEV, encephalitic alphavirus
CLARK, RACHAEL ANNBRIGHAM AND WOMEN'S HOSPITALIdentification of agents that induce E-selectin on human endothelial cells
CONNOR, JOHN HBOSTON UNIVERSITY MEDICAL CAMPUSStage-Specific Inhibitors of Orthopoxviruses
CONTESSA, JOSEPH NYALE UNIVERSITYA bioluminescent screen for inhibitors of N-linked glycosylation
CRABTREE, GERALD RSTANFORD UNIVERSITYScreen for Small Molecule Inhibitors of ATP Dependent Chromatin Remodeling
DALLMANN, H. GARRYUNIVERSITY OF COLORADO AT BOULDERScreening for Inhibitors of DNA Replication in Gram-Positive Bacteria
DANG, LENNYAGIOS PHARMACEUTICALS, INC.HTS for inhibitors of IDH1m & synthetic-lethal in tumor cells producing 2HG
DAUGHERTY, PATRICK SUNIVERSITY OF CALIFORNIA SANTA BARBARASerine protease zymogen activation by small molecules
DAVEY, ROBERT AUNIVERSITY OF TEXAS MEDICAL BR GALVESTONHTS for Filo- and Arena-virus Entry Mechanisms
DESHAIES, RAYMOND JCALIFORNIA INSTITUTE OF TECHNOLOGYHTS for Rpn11 chemical probes
DISNEY, MATTHEW DSCRIPPS FLORIDAHTS to Identify Small Molecules Targeting Repeating Transcripts
DONG, XINZHONGJOHNS HOPKINS UNIVERSITYA screen for small molecule modulators of human GPCR MrgX1
ERKINE, ALEXANDRE M.BUTLER UNIVERSITYSelective Inhibitors of Human HSF2
FISHER, PAUL BVIRGINIA COMMONWEALTH UNIVERSITYScreening strategy for small molecules inhibitors of cancer
FLAUMENHAFT, ROBERT CBETH ISRAEL DEACONESS MEDICAL CENTERIdentification of small molecule inhibitors of protein disulfide isomerase
FLETTERICK, ROBERT JUNIVERSITY OF CALIFORNIA SAN FRANCISCOScreening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
FORTE, MICHAEL A (contact)
BOURDETTE, DENNIS NEIL
OREGON HEALTH AND SCIENCE UNIVERSITYSmall Molecules Targeting the Mitochondrial Permeability Transition
FREED, ERICNATIONAL CANCER INSTITUTEDiscovery of lead compounds that inhibit HIV-1 budding by blocking the interaction
FRIZZELL, RAYMOND AUNIVERSITY OF PITTSBURGH AT PITTSBURGHTrans-NIH Research Support
FRYDMAN, JUDITHSTANFORD UNIVERSITYHigh-Throughput Screening for Modulators of Cytosolic Chaperonin Activity
GEHRING, KALLEMCGILL UNIVERSITYHTS Screening for small-molecule inhibitors of microRNA-mediated mRNA deadenylati
GEISS, BRIANCOLORADO STATE UNIVERSITY-FORT COLLINSA High-Throughput Assay for Probes of the Flavivirus RNA Guanylyltransferase
GERSHENGORN, MARVIN CU.S. NATIONAL INST DIABETES/DIGST/KIDNEYHigh Throughput Screening for Biased Agonists of the TSH Receptor that Activate t
GERSHENGORN, MARVIN CU.S. NATIONAL INST DIABETES/DIGST/KIDNEYQuantitative High-Throughput Screening for Small Molecule Antagonists of Human TSHR
GERSHENGORN, MARVIN CU.S. NATIONAL INST DIABETES/DIGST/KIDNEYqHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor
GLIMCHER, LAURIE HOLLISHARVARD UNIVERSITY (SCH OF PUBLIC HLTH)Schnurri-3 Inhibitors: specific inducers of adult bone formation
GOLUBKOV, VLADISLAVSANFORD-BURNHAM MEDICAL RESEARCH INSTITA High Content Screen to Identify Inhibitors of MT1-MMP Activation
GOTTESMAN, MICHAEL (contact)
HALL, MATTHEW DAVID
SIMEONOV, ANTON MOMTCHILOV
KOPIN, ALAN S
NATIONAL CANCER INSTITUTEA high-throughput screen for MDR1-selective chemotherapeutics
GOULD, ROBERTBROAD INSTITUTE, INC.Screen for Inhibitors of STK-33 Kinase Activity
GRAVES, STEVEN WUNIVERSITY OF NEW MEXICOHigh-throughput multiplex microsphere screening for toxin protease inhibitors
GRIMALDI, MAURIZIOSOUTHERN RESEARCH INSTITUTEA fully validated assay to identify activators of ERSR in human glioma cells: identification of small molecules with potential gliotoxic activity
HAHN, WILLIAM CDANA-FARBER CANCER INSTITUTEDiscovering modulators of PAX8 for targeting ovarian cancer
HALDAR, KASTURI (contact)
ZHENG, WEI
UNIVERSITY OF NOTRE DAMEMalaria Phosphatase Inhibitors Identified as a Potential New Malaria Treatment
HARDY, JEANNE ANNUNIVERSITY OF MASSACHUSETTS AMHERSTCaspase-6 allosteric inhibitors: activity probes and neurodegeneration treatment
HARLAN-WILLIAMS, LISA MUNIVERSITY OF KANSAS MEDICAL CENTERHTS Assay to Identify Small Molecule Activators of BRCA1 Expression
HARRIS, REUBEN SUNIVERSITY OF MINNESOTA TWIN CITIESAPOBEC3G DNA Deaminase Inhibitor High Throughput Screen
HERZBERG, OSNATUNIVERSITY OF MARYLAND COLLEGE PK CAMPUSCompound library screening using Giardia labmblia high throughput viability assay
HU, LONGQINRUTGERS THE ST UNIV OF NJ NEW BRUNSWICKHTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction
IADAROLA, MICHAEL JU.S. NAT'L INST/DENTAL/CRANIOFACIAL RESHTS for Identifying Allosteric Modulators of TRPV1 receptor
IMPERIALI, BARBARAMASSACHUSETTS INSTITUTE OF TECHNOLOGYInhibition of Glycoprotein Biosynthesis in Gram-Negative Pathogens
INIGUEZ LLUHI, JORGE AUNIVERSITY OF MICHIGAN AT ANN ARBORChemical probes targeting the SUMO protease SENP1 in Prostate Cancer
IOANNOU, YIANNIS AMOUNT SINAI SCHOOL OF MEDICINE OF NYUHTS of NPC1 promoter activators
IOANNOU, YIANNIS AMOUNT SINAI SCHOOL OF MEDICINE OF NYUHTS of Rab9 Promoter Activators
JACOBSON, DAVID AARONVANDERBILT UNIVERSITYSmall molecule modulators of the two-pore-domain potassium channel, TREK-2
JANZEN, WILLIAM PERRYUNIVERSITY OF NORTH CAROLINA CHAPEL HILLHigh-Throughput Screening for the Discovery of Novel Scaffolds that Antagonize Methylated Histone Recognition
JARVIK, JONATHAN WCARNEGIE-MELLON UNIVERSITYHTS FOR NON-CANONICAL LIGANDS FOR BETA 2 ADRENERGIC RECEPTOR INTERNALIZATION
JENKINSON, SARAH RHIANNON (contact);
CHEN, CATHERINE;
HODES, RICHARD JOEL
NATIONAL CANCER INSTITUTEIdentification of small molecule activator of co-stimulatory pathways for T cell
JENNINGS, PATRICIA AUNIVERSITY OF CALIFORNIA SAN DIEGOHTS for Modulators of MitoNEET Proteins' Function
JONSSON, COLLEEN BUNIVERSITY OF LOUISVILLEDiscovery of Small Molecule Probes for Influenza NS1A
KAUFMAN, RANDAL JUNIVERSITY OF MICHIGAN AT ANN ARBORHTP chemical genomic screens to identify positive regulators of the Unfolded Protein Response
KIM, HEE-YONGU.S. NATIONAL INST ALCOHOL AB/ALCOHOLISMHigh Throughput Screening (HTS) for Akt/mTORC2: Identification of Novel Inhibitor
KITSIS, RICHARD NALBERT EINSTEIN COL OF MED YESHIVA UNIVHigh-Throughput Screen for Small Molecules that Modulate Myocardial Damage
KOH, MEI YEEUNIVERSITY OF TEXAS MD ANDERSON CAN CTRHigh-throughput screen for specific small-molecule inhibitors of HIF-2A activity
KOPIN, ALAN STUFTS MEDICAL CENTERBursicon Receptor Antagonists: Templates for Developing Novel Insecticides
KRISHNAMURTHY, PARTHA CUNIVERSITY OF KANSAS MEDICAL CENTERHigh Throughput Screening for Inhibitors of the ABC Transporter ABCB6
KUNG, ANDREW L (contact)
STEGMAIER, KIMBERLY
DANA-FARBER CANCER INSTITUTETargeting the ETS Transcription Factor Rearrangement EWS/FLI in Ewing's Sarcoma
LANDER, ERIC SBROAD INSTITUTE, INC.High-throughput screening for small molecules with specific toxicity for breast cancer stem cells
LASMEZAS, CORINNE IDASCRIPPS FLORIDAHigh Throughput Screening for compounds reducing cell surface prion protein
LEE, JEANNIE TMASSACHUSETTS GENERAL HOSPITALHTS of Gamma Glutamyl Transpeptidase for the Discovery of Novel Antimicrobials
LIANG, T. JAKE (contact)
ZHENG, WEI
U.S. NATIONAL INST DIABETES/DIGST/KIDNEYQuantitative High Throughput Screen to Identify Novel Antivirals against Hepatiti
LIEBER, MICHAEL RUNIVERSITY OF SOUTHERN CALIFORNIASelective Inhibitors of the Artemis Endonuclease
LINDQUIST, SUSAN L.WHITEHEAD INSTITUTE FOR BIOMEDICAL RESIdentification of malaria Hsp40 chaperone inhibitors in yeast
LINDQUIST, SUSAN L.WHITEHEAD INSTITUTE FOR BIOMEDICAL RESIdentification of compounds that reverse cellular toxicity of A beta peptide in a
LLOYD, R STEPHENOREGON HEALTH AND SCIENCE UNIVERSITYInhibitors of DNA polymerase kappa
LORSCH, JON RJOHNS HOPKINS UNIVERSITYModulators of the fidelity of start codon recognition in eukaryotes
LU, KUN PINGBETH ISRAEL DEACONESS MEDICAL CENTERIdentification of Pin1 Chemical Probes for Studying Phosphorylation Signaling
MAEGAWA, GUSTAVO HENRIQUE BOFFJOHNS HOPKINS UNIVERSITYA Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase
MAHLEY, ROBERT W.J. DAVID GLADSTONE INSTITUTESApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
MANKIN, ALEXANDER S (contact)
ORELLE, CEDRIC
UNIVERSITY OF ILLINOIS AT CHICAGOInhibitors of Bacterial Protein Synthesis with Novel Modes of Action
MARCHAND, CHRISTOPHENATIONAL CANCER INSTITUTEQuantitative High-throughput Discovery of Human Tyrosyl-DNA Phosphodiesterase I (Tdp1) Inhibitors
MARUGAN, JUAN J (contact)
FERRER, MARC 
OLEFSKY, JERROLD MICHAEL
U.S. NATIONAL HUMAN GENOME RESEARCH INSTIdentification of GPR120 B-arrestin-2 Biased Agonists for the Treatment of Insuli
MAURIZI, MICHAEL ROBERTNATIONAL CANCER INSTITUTEHigh throughput screen to identify activators of Bacillus subtilis ClpP with anti
MAZIN, ALEXANDER VDREXEL UNIVERSITYDevelopment of RAD52 inhibitors to induce synthetic lethality of BRCA2-deficient
MAZIN, ALEXANDER VDREXEL UNIVERSITYIdentification of inhibitors of RAD54, an important DNA repair protein
MINOND, DMITRIYTORREY PINES INST FOR MOLECULAR STUDIESHTS Assays to Discover Selective Inhibitors of ADAM10 and 17
MOWEN, KERRI ASCRIPPS RESEARCH INSTITUTEAn Activity-Based Assay to Screen for PRMT1 Inhibitors
NELSON, WILLIAM GEORGEJOHNS HOPKINS UNIVERSITYScreen for Small Molecule Antagonists of MBD2
NEUBIG, RICHARD RUNIVERSITY OF MICHIGAN AT ANN ARBORCell-based Screen for RGS Modulators
OSTERMAN, ANDREI LSANFORD-BURNHAM MEDICAL RESEARCH INSTITInhibitors of Staphylococcus aureus NaMN adenylyltransferase NadD
PARRA, KARLETT JUNIVERSITY OF NEW MEXICO HEALTH SCIS CTRFlow Cytometry HTS of Small Molecules that Regulate V-ATPase Proton Transport
PATHAK, VINAY K.NATIONAL CANCER INSTITUTEIdentification of Small Molecule Inhibitors of Vif-A3G and Vif-A3F Interactions as Novel Antiviral Agents for Treatment of HIV-1 Infection
PEGAN, SCOTT DUSANUNIVERSITY OF DENVER (COLORADO SEMINARY)Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
PETROSKI, MATTHEWSANFORD-BURNHAM MEDICAL RESEARCH INSTITHigh throughput screening for modulators of UBC12
POMMIER, YVESNATIONAL CANCER INSTITUTEIdentification of human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) repair inhibitors
PRELICH, GREGORYYESHIVA UNIVERSITYA High-throughput in Vivo Screen for Small Molecule Inhibitors of SUMOylation
PROSSNITZ, ERIC RUNIVERSITY OF NEW MEXICO HEALTH SCIS CTRMLP Assay for Arrestin-AP2 Inhibitors
PUIGSERVER, PEREDANA-FARBER CANCER INSTITUTEHTS of Compounds Modulating PGC-1a Acetylation and Oxidative Metabolic Function
REDDY, SITA (contact)
NEAMATI, NOURI
UNIVERSITY OF SOUTHERN CALIFORNIAHigh Throughput Screen for Myotonic Dystrophy Type 1
RICKERT, ROBERT CSANFORD-BURNHAM MEDICAL RESEARCH INSTITUTEFunctional Antagonists of EBI12/GPR183 as chemical probes for inflammation
ROTH, GREGORY PAULSANFORD-BURNHAM MEDICAL RESEARCH INSTITUTEProbing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis
RUOSLAHTI, ERKKISANFORD-BURNHAM MEDICAL RESEARCH INSTITHigh-throughput screen to identify modulators of CendR-mediated cellular uptake
SABATINI, DAVID M.WHITEHEAD INSTITUTE FOR BIOMEDICAL RESInhibitors of serine biosynthesis
SALVESEN, GUY SSANFORD-BURNHAM MEDICAL RESEARCH INSTITSelective Allosteric Inhibitors of SENP8
SASAKI, ATSUOBETH ISRAEL DEACONESS MEDICAL CENTERChemical probes that modulate a stress pathway phosphatidylinositol 5-phosphate 4
SHAMJI, ALYKHANBROAD INSTITUTE, INC.Development of Small-Molecule Probes of the Histone Methyltransferase NSD2
SHEWMAKER, FRANK PHENRY M. JACKSON FDN FOR THE ADV MIL/MEDMolecular library screen for suppressors of FUS proteinopathy
SIBLEY, DAVID R.U.S. NATIONAL INST/NEURO/DS/STROKEDiscovery of Novel Allosteric Modulators of the D3 Dopamine Receptor
SIDEROVSKI, DAVID PUNIVERSITY OF NORTH CAROLINA CHAPEL HILLEnzymatic Screen for RGS Protein Modulators
SLUSHER, BARBARA STAUCHJOHNS HOPKINS UNIVERSITYHTS Screening for Glutaminase Inhibitors
SODROSKI, JOSEPH GDANA-FARBER CANCER INSTITUTEBroad-range Inhibitors of Human Immunodeficiency Virus Entry
STAMM, STEFANUNIVERSITY OF KENTUCKYIdentification of substances that change alternative pre-mRNA splicing of the serotonin 2C receptor
STANLEY, JOHN RUNIVERSITY OF PENNSYLVANIAHigh throughput screening to find inhibitors of pathogenic pemphigus antibodies
STERN, LAWRENCE JUNIV OF MASSACHUSETTS MED SCH WORCESTERSmall molecule probes of ERAP-1
SYKES, DAVID BMASSACHUSETTS GENERAL HOSPITALDiscovering small molecules that overcome differentiation arrest in acute myeloid
TAUTZ, LUTZSANFORD-BURNHAM MEDICAL RESEARCH INSTITSTEP inhibitors for intervention in Alzheimer's Disease
TESMER, JOHN J GUNIVERSITY OF MICHIGAN AT ANN ARBORRNA Aptamer-Based Screen for Selective Inhibitors of GRK2
TORTORELLA, DOMENICOMOUNT SINAI SCHOOL OF MEDICINE OF NYUIdentification of Inhibitors that Stabilize ER Degradation Substrates
TORTORELLA, DOMENICOMOUNT SINAI SCHOOL OF MEDICINEIdentification of novel inhibitors targeting entry of human cytomegalovirus
UMEMORI, HISASHIUNIVERSITY OF MICHIGAN AT ANN ARBORSmall Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy
VUORI, KRISTIINASANFORD-BURNHAM MEDICAL RESEARCH INSTITHTS for Caspase-8 selective TRAIL Sensitizers
WAHL, GEOFFREY MYLESSALK INSTITUTE FOR BIOLOGICAL STUDIESHigh Throughput Screen for Inhibitors of the mdm2/mdmx Interaction
WALKINSHAW, MALCOLM DOUGLASUNIVERSITY OF EDINBURGHIdentification of glycolytic pathway inhibitors against Trypanosoma cruzi pyruvat
WEISSBACH, HERBERTFLORIDA ATLANTIC UNIVERSITYHigh Throughput Assay for Activators and Inhibitors of MSRA
WENNERBERG, KRISTERSOUTHERN RESEARCH INSTITUTEDiscovery of small molecule inhibitors of the oncogenic and cytokinetic protein M
WHITESELL, LUKE JWHITEHEAD INSTITUTE FOR BIOMEDICAL RESIdentifying species-specific anti-malarial Hsp90 inhibitors using genetically engineered yeast
WILSON, SAMUEL HU.S. NATIONAL INST OF ENVIRON HLTH SCISDiscovery and Characterization of Human DNA Polymerase Beta Inhibitors
WOODGATE, ROGERU.S. NATIONAL INST/CHILD HLTH/HUMAN DEVHigh Throughput Screening to Identify Inhibitors of Human DNA Polymerase eta and polymerase iota
WU, MENGJOHNS HOPKINS UNIVERSITYSubtype-Specific Small Molecule Chemical Probes for Non-neuronal KCNQ1 Potassium Channel
WU, MENGJOHNS HOPKINS UNIVERSITYDevelopment of Bioactive Chemical Probes for Calcium-activated Chloride Channel
WU, XIAOHUACAROLINAS MEDICAL CENTERHTS for Enhancer of Glycosylation of Alpha Dystroglycan
XU, HAOXINGUNIVERSITY OF MICHIGAN AT ANN ARBORKinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion c
YOULE, RICHARD JAMESU.S. NATIONAL INST/NEURO/DS/STROKEHigh content screening for small molecule modulators of Pink1 expression and mito
YOUNG, RICHARD AWHITEHEAD INSTITUTE FOR BIOMEDICAL RESDiscovery of small molecule inhibitors of c-Myc/Mac dimerization and DNA binding
YUE, DAVID TJOHNS HOPKINS UNIVERSITYModulators of CaV1.3 Ca2+ regulation
XU, WEIUNIVERSITY OF WISCONSIN MADISONIdentification of ERalpha/ERbeta Heterodimer-specific Ligands by HTS
ZHANG, YAN JESSIEUNIVERSITY OF TEXAS AUSTINDiscovery of Inhibitors for Small C-terminal Domain Phosphatases
ZHAO, RUI (contact)
FORD, HEIDE L
UNIVERSITY OF COLORADO DENVERIdentify inhibitors of the Six1/Eya interaction using high throughput screening
ZHAO, RUI (contact)
ZHANG, QINGHONG
UNIVERSITY OF COLORADO DENVERIdentify Inhibitors of the Transcriptional Co-Repressor CtBP Using HTS for Cancer
ZHENG, WEI, Contact
REMALEY, ALAN THOMAS
U.S. NATIONAL HUMAN GENOME RESEARCH INSTIdentification of Acid Sphingomyelinase Inhibitors for the Treatment of Atherosclerosis
ZHENG, WEI (contact)
SHILOH, YOSEF
U.S. NATIONAL HUMAN GENOME RESEARCH INSTHTS for Identifying Potential Drug Treatment of Ataxia-Telangiectasia
ZHUANG, ZHIHAOUNIVERSITY OF DELAWAREDiscovery of inhibitors against ubiquitin specific protease in human DNA damage r

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Solicitation of Assays for HTS in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03/X01)
PAR-08-034 & PAR-08-035
PI NameInstitution NameTitle
ABOOD, MARY ECALIFORNIA PACIFIC MED CTR RES INSTITUTEScreening for Selective Ligands for GPR55
AULD, DOUGLAS
BELLER, MATHIAS (contact)
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRYqHTS to Identify Modulators of Lipid Storage
AGOULNIK, ALEXANDER I.BAYLOR COLLEGE OF MEDICINESmall molecule agonists of the relaxin receptor
ANDROPHY, ELLIOT JUNIV OF MASSACHUSETTS MED SCH WORCESTERHigh Throughput Screen for SMA
BARAK, LAWRENCE S.DUKE UNIVERSITYAntagonists for the Orphan Receptor GPR-35
BARAK, LAWRENCE SDUKE UNIVERSITYAgonists and Antagonists for the Kappa Opioid Receptor
BASSLER, BONNIE LPRINCETON UNIVERSITYA High-Throughput Screen for LuxS Quorum-Sensing Inhibitors
BEZPROZVANNY, ILYA B.UNIVERSITY OF TEXAS SW MED CTR/DALLASHTS Screen for Small Molecule Inhibitors of Mint-PDZ Domain
BISHAI, WILLIAM RAMSESJOHNS HOPKINS UNIVERSITYScreen for Synthetic Lethality in Mycobacterium Tuberculosis
BOKOCH, GARY M.SCRIPPS RESEARCH INSTITUTEHTS For Inhibitors of NADPH Oxidase 1 (Nox1)
BRODSKY, JEFFREY LUNIVERSITY OF PITTSBURGH AT PITTSBURGHIdentification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent
BUGGE, THOMAS HU.S. NAT'L INST/DENTAL/CRANIOFACIAL RESInhibitors of Cell Surface uPA Generation
BURHANS, WILLIAM CROSWELL PARK CANCER INSTITUTE CORPA yeast HTS for caloric restriction mimetics that inhibit age-related superoxide
BUSHWELLER, JOHN HACKETTUNIVERSITY OF VIRGINIA CHARLOTTESVILLEScreening for Inhibitors of MLL Translocation Proteins in Leukemia
CHEN, YUANCITY OF HOPE/BECKMAN RESEARCH INSTITUTEA high throughput screening assay for the identification of SUMOylation inhibitor
CIVELLI, OLIVIERUNIV OF CALIFORNIA IRVINEHigh-Throughput Assay for G-Protein Coupled Receptors in Pain Research
DENISON, MICHAEL STEVENUNIVERSITY OF CALIFORNIA DAVISHigh Throughput Screening for Activators of the Ah Receptor
DESHAIES, RAYMOND JCALIFORNIA INSTITUTE OF TECHNOLOGYHigh-Throughput Campaign to Identify Reversible Small Molecule Inhibitor of p97/C
ECKENHOFF, RODERIC G.UNIVERSITY OF PENNSYLVANIAHigh throughput screening of a general anesthetic binding site
ENGEL, DANIEL AUNIVERSITY OF VIRGINIA CHARLOTTESVILLEHigh Throughput Screen for Inhibitors of Influenza NS1 Protein Function
FLAUMENHAFT, ROBERT CBETH ISRAEL DEACONESS MEDICAL CENTERChemical Genetic Analysis of Platelet Granule Secretion
FRICK, DAVID N.NEW YORK MEDICAL COLLEGEHepatitis C VIrus NS3 Helicase Inhibitor Discovery
GARDINER, DONALD LQUEENSLAND INSTITUTE OF MEDICAL RESEARCHIdentification of Inhibitors of the Plasmodium Falciparum M18 Metalloprotease
GILBERT, SHAWN ROBERTUNIVERSITY OF ALABAMA AT BIRMINGHAMIdentification of Molecular Probes to Activate the Hypoxia Inducible Factor Pathw
GILEADI, OPHER (contact);
VINDIGNI, ALESSANDRO
UNIVERSITY OF OXFORDSmall-molecule inhibitors of the human RECQ1 and Bloom DNA helicases
GOLUB, TODD R.MASSACHUSETTS INSTITUTE OF TECHNOLOGYDiscovery of inhibitors of anti-apoptotic protein A1
GOULD, ROBERTMASSACHUSETTS INSTITUTE OF TECHNOLOGYDiscovering Inhibitors of histone demethylase GASC-1
GREMBECKA, JOLANTA (contact)
CIERPICKI, TOMASZ
UNIVERSITY OF VIRGINIA CHARLOTTESVILLEScreening for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leuke
HAGGARTY, STEPHEN J
PAN, JEN (contact)
MASSACHUSETTS INSTITUTE OF TECHNOLOGYDiscovery of potent, and selective allosteric inhibitors of GSK-3b
HARDING, HEATHER PNEW YORK UNIVERSITY SCHOOL OF MEDICINEScreen for Inhibitors of 2' Phosphotransferase
HASLAM, DAVID BWASHINGTON UNIVERSITYA SCREEN FOR SMALL MOLECULE INHIBITORS OF SHIGA TOXIN AND RICIN ACTIVITY
HEIL, MARINTHA LSOUTHERN RESEARCH INSTITUTEA Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activ
HEILIG, MARKUS ALEXANDERU.S. NATIONAL INST ALCOHOL AB/ALCOHOLISMIdentification of Small Molecule Antagonists for the Neuropeptide Receptor Using
HERZBERG, OSNATUNIVERSITY OF MD BIOTECHNOLOGY INSTITUTEHTP Screen of Compounds that Inhibit Giardia Fructose-1,6-Bisphosphate Aldolase
HONKANEN, RICHARD EUNIVERSITY OF SOUTH ALABAMAHTP screening for inhibitors of ser/the protein phosphatase 5
HUANG, SUINORTHWESTERN UNIVERSITYA Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
HUNG, DEBORAH TMASSACHUSETTS INSTITUTE OF TECHNOLOGYElucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis
HWANG, INKYUSCRIPPS RESEARCH INSTITUTEThe High Throughput Screening for Developing T Cell Immune Modulators
JARSTFER, MICHAEL BUNIVERSITY OF NORTH CAROLINA CHAPEL HILLAllosteric Potentiators of the Oxytocin System for the Control of Social Motivation
KAUFMAN, RANDAL JUNIVERSITY OF MICHIGAN AT ANN ARBORHigh Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
KOEHLER, CARLA M.UNIVERSITY OF CALIFORNIA LOS ANGELESSmall molecule modulators for mitochondrial protein import
KOEHLER, CARLA M.UNIVERSITY OF CALIFORNIA LOS ANGELESSmall Molecule Modulators for Redox Regulation in the Mitochondrial Intermembrane
KUPERSHMIDT, SABINAVANDERBILT UNIVERSITYIdentification of compounds that protect HERG from block by proarrhythmic agents
LAI, KENTUNIVERSITY OF MIAMI SCHOOL OF MEDICINEToward Improved Therapy for Classic Galactosemia
LEVINE, ROSS LSLOAN-KETTERING INSTITUTE FOR CANCER RESHigh Throughput Screen for JAK2V617F Mutant Selective Inhibitors
LI, MINJOHNS HOPKINS UNIVERSITYDevelopment of Chemical Probes for KCNQ Potassium Channels
LINDQUIST, SUSAN L.WHITEHEAD INSTITUTE FOR BIOMEDICAL RESReversing Antifungal Drug Resistance
LITTMAN, DAN RNEW YORK UNIVERSITY SCHOOL OF MEDICINEScreen for Small Molecule Compounds that Modulate the Transcriptional Activity of
MAKHINA, ELENAUNIVERSITY OF PITTSBURGH AT PITTSBURGHHigh Throughput Screening for Potassium Channel Modulators
MAZIN, ALEXANDER VDREXEL UNIVERSITYA Screen for Modulators of Human Rad51, a Key DNA Repair Protein
MCDONOUGH, PATRICK MVALA SCIENCES, INCA High Throughput Imaging Assay for Hepatic Lipid Droplet Formation
MILLAN, JOSE LUISBURNHAM INSTITUTE FOR MEDICAL RESEARCHThe Role of PHOSPHO1 in the Initiation of Skeletal Calcification
MISTELI, TOMU.S. NATIONAL CANCER INSTITUTEA high-throughput screen for pre-mRNA splicing modulators
MOORE, CLAIRE L;
KUMAMOTO, CAROL A
TUFTS UNIVERSITY BOSTONHigh throughput screening for polyadenylation inhibitors using the MLSCN library
NAKAMURA, KAZUHIROUNIVERSITY OF NORTH CAROLINA CHAPEL HILLTR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain Interaction
PAULUS, HENRYBOSTON BIOMEDICAL RESEARCH INSTITUTEIntein inhibitors as potential TB drugs
PELLECCHIA, MAURIZIOBURNHAM INSTITUTE FOR MEDICAL RESEARCHNovel Chemical Probes Targeting the FRB Domain of mTOR
PELLETIER, JERRYMC GILL UNIVERSITYInterdicting Eukaryotic Translation Initiation Factor-RNA Interaction
REED, JOHN CSANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCHHigh Throughput Screening Assays for NOD1 and NOD2 Inhibitors
REED, JOHN CSANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCHChemical Modulation of the Siah-1 Pathway
REED, JOHN CSANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCHHTS Assay for UBC13, a Mediator of Inflammatory Signaling
REISMAN, DAVID NUNIVERSITY OF MICHIGAN AT ANN ARBORReverse the Epigenetic Suppression of BRM through High Throughput Screening
RODRIGUEZ, ANANEW YORK UNIVERSITY SCHOOL OF MEDICINENew Drugs for Acute and Chronic Stages of Trypanosome Cruzi
RUGGIERO, ALICIA M.VANDERBILT UNIVERSITYA Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators
SCHMIDT, WALTER K.UNIVERSITY OF GEORGIA (UGA)Discovery of Specific Cell-Permeable Inhibitors of the Ras Converting Enzyme
STOCKWELL, BRENT RCOLUMBIA UNIV NEW YORK MORNINGSIDEScreen for RAS-Selective Lethal Compounds and VDAC Ligands
STROSBERG, ARTHUR DONNYSCRIPPS RESEARCH INSTITUTEHTS Assay for Inhibitors of HCV Core Protein
SUN, HONGMINUNIVERSITY OF MISSOURI-COLUMBIAHigh Throughput Screening for Small Compounds to Inhibit the Expression of Strept
TAUTZ, LUTZSANFORD-BURNHAM MEDICAL RESEARCH INSTITSmall-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR
THORNTON, CHARLES A.UNIVERSITY OF ROCHESTERInhibitors of MBNL1 - poly(CUG)binding
TOKARS, VALERIE L.UNIVERSITY OF ILLINOIS AT CHICAGOHigh Throughput Screening for Identifying Lead Compounds Against 3CLpro
VANDER HEIDEN, MATTHEWDANA-FARBER CANCER INSTITUTEDiscovery of Lead Compounds which Modulate Tumor Specific Pyruvate Kinase M2 Acti
WALKINSHAW, MALCOLM DOUGLASUNIVERSITY OF EDINBURGHDiscovery of Lead Compounds Against Trypanosomiasis and Leishmaniasis Through Ind
WANG, ZHIYONGSALK INSTITUTE FOR BIOLOGICAL STUDIESHigh throughput screen for the master regulator of obesity and diabetes p/CIP
WERNER-WASHBURNE, MARGARET C.UNIVERSITY OF NEW MEXICOChemical Screen of TOR pathway GFP fusion proteins in S. cerevisiae
WHITESELL, LUKE JWHITEHEAD INSTITUTE FOR BIOMEDICAL RESIdentifying Small Molecules To Probe the Role of Heat Shock Factor 1 in Cancer
WILSON, DAVID M.U.S. NATIONAL INSTITUTE ON AGINGHigh Throughput Screening to Identify Inhibitors of the Human Abasic Endonuclease
YANG, VINCENT WEMORY UNIVERSITYHigh Throughput Screen for Small Molecule Inhibitors of Colorectal Cancer Cell Pr
ZHENG, WEIU.S. NATIONAL HUMAN GENOME RESEARCH INSTMultiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington?
ZHENG, WEIU.S. NATIONAL HUMAN GENOME RESEARCH INSTIdentification of Activators and Inhibitors of alpha-Glucosidase as Potential Cha
ZHENG, WEIU.S. NATIONAL HUMAN GENOME RESEARCH INSTHTS for Identifying Activators and Inhibitors of Alpha-Galactosidase A for the Po

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03/X01)
PAR-06-259 & PAR-06-545
PI NameInstitution NameTitle
BALLATORE, CARLOUNIVERSITY OF PENNSYLVANIAHigh Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi
BUGGE, THOMAS HU.S. NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCHQuantitative High Throughput Screening for Anthrax Toxin Inhibitors
BURKART, MICHAEL DUNIVERSITY OF CALIFORNIA SAN DIEGOA qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases
BUSHWELLER, JOHN HUNIVERSITY OF VIRGINIA CHARLOTTESVILLEScreening for Inhibitors of Runx and CBFb Translocation Products in Leukemia
COLLER, BARRY SROCKEFELLER UNIVERSITYHigh Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3
COOMBS, GARYUNIVERSITY OF UTAHThe Role of Wnts in Stem Cell
DAY, BILLY WUNIVERSITY OF PITTSBURGH AT PITTSBURGHHTS Assays for Microtubule Stabilizers
FREEZE, HUDSON HBURNHAM INSTITUTE FOR MEDICAL RESEARCHTherapeutic Inhibitors of Phosphomannose Isomerase
GARDINER, DONALD L (Contact);
TRENHOLME, KATHARINE RUTH
DALTON, JOHN PIU
QUEENSLAND INSTITUTE OF MEDICAL RESEARCHHigh Through-Put Screening of Plasmodium Falciparum Aminopeptidases
GERSHENGORN, MARVIN CU.S. NATIONAL INST DIABETES/DIGST/KIDNEYLigand Discovery for Thyroid-Stimulating Hormone Receptor (TSHR) by Virtual and H
GLASS, JONATHAN DAVIDEMORY UNIVERSITYDiscovering Calpain Inhibitors of Neurological Diseases
GRIMALDI, MAURIZIOSOUTHERN RESEARCH INSTITUTEAn HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators
HASELBECK, ROBERT JOHNRX3 PHARMACEUTICALS, INC.Identification of Target-Specific Antimicrobials
HELLER, STEFANSTANFORD UNIVERSITYIdentification of Modulators of the TRPML3 and TRPN1 ion Channels
HOLMAN, THEODORE RUNIVERSITY OF CALIFORNIA SANTA CRUZHigh Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors
KOLE, RYSZARDUNIVERSITY OF NORTH CAROLINA CHAPEL HILLModulation of Alternative Splicing by HTS Identified Compounds
LARSON, RICHARD SUNIVERSITY OF NEW MEXICO ALBUQUERQUEMultiplex Screening for ABC Transporter Inhibitors
LEISSRING, MALCOLM ASCRIPPS RESEARCH INSTITUTEHTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme
LEWIS, KIMNORTHEASTERN UNIVERSITYScreening C. Albicans Biofilms for Lethal Potentiators of Miconazole
LI, QIANJUNUNIVERSITY OF ALABAMA AT BIRMINGHAMA HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
LIU, PU PAULU.S. NATIONAL HUMAN GENOME RESEARCH INSTHigh-Throughput Screening for Compounds Blocking Interaction Between CBFb-SMMHC a
MARSHALL, WALLACEUNIVERSITY OF CALIFORNIA SAN FRANCISCOSmall Molecule Inhibitors of Cilia
MATTS, ROBERT LOKLAHOMA STATE UNIVERSITY STILLWATERHigh Throughput Screen for Hsp90 Inhibitors
MCDONOUGH, PATRICK MVALA SCIENCES, INCHigh Throughput Imaging Assay for Beta-Catenin
MCNEIL, MICHAEL RCOLORADO STATE UNIVERSITY – FORT COLLINSHTS Screen of TB RmIC & RmID dTDP-Rhamnose Formation Enzymes
MILLAN, JOSE LUISBURNHAM INSTITUTE FOR MEDICAL RESEARCHActivators of the Pyrophosphatase Activity of Alkaline Phosphatase
MORRIS, JAMES CULVINCLEMSON UNIVERSITYIdentification of Inhibitors of Trypanosoma Brucei Hexokinases
NATARAJAN, AMARNATHUNIVERSITY OF TEXAS MEDICAL BR GALVESTONHTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Int
NUNNARI, JODI MUNIVERSITY OF CALIFORNIA DAVISChemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors
PASSER, BRENT JMASSACHUSETTS GENERAL HOSPITALA High-Throughput Screen to Identify Small Molecule Compounds That Augment
PELLECCHIA, MAURIZIOBURNHAM INSTITUTE FOR MEDICAL RESEARCHNovel Chemotypes Against Influenza A Virus
PELLETIER, JERRYMCGILL UNIVERSITYScreening for Small Molecule Inhibitors of Eukaryotic Translation Initiation
PLEMPER, RICHARD K.EMORY UNIVERSITYHigh Throughput Screening-Based Identification of Measles Virus Probes
REED, JOHN CBURNHAM INSTITUTE FOR MEDICAL RESEARCHChemical Antagonists of IAP-Family Anti-Apoptotic Proteins
REED, JOHN CBURNHAM INSTITUTE FOR MEDICAL RESEARCHChemical Inhibitors of ER Stress
RON, DAVIDNEW YORK UNIVERSITY SCHOOL OF MEDICINEScreening for Inhibitors of the Integrated Stress Response
ROZANOV, DMITRIBURNHAM INSTITUTE FOR MEDICAL RESEARCHScreening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells
SEVERSON, WILLIAM ESOUTHERN RESEARCH INSTITUTEA Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus
SEVERSON, WILLIAM ESOUTHERN RESEARCH INSTITUTEA Cell Based HTS Approach for the Discovery of New Inhibitors of RSV
SHOICHET, BRIAN KUNIVERSITY OF CALIFORNIA SAN FRANCISCOPromiscuous and Specific Inhibitors of Cruzain
SMITH, SUSAN M.E.EMORY UNIVERSITYHTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes
SMITHGALL, THOMAS EDWARDUNIVERSITY OF PITTSBURGH AT PITTSBURGHTargeting HIV-1 Nef with Small Molecules
STAUFFACHER, CYNTHIA VPURDUE UNIVERSITY WEST LAFAYETTEScaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
STOCKWELL, BRENT RCOLUMBIA UNIV NEW YORK MORNINGSIDELuciferase Screen for MDM2 E3 Ligase Inhibitors
TOBIAS, PETER SSCRIPPS RESEARCH INSTITUTEHigh Throughput Screening for Toll-Like Receptors
WANDINGER-NESS, ANGELAUNIVERSITY OF NEW MEXICO ALBUQUERQUEHTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras-
WANG, QIMING JANEUNIVERSITY OF PITTSBURGH AT PITTSBURGHIMAP-Based Fluorescent Polarization Assay for High Throughput Screening of Protein
YIN, XIAO-MINGUNIVERSITY OF PITTSBURGH AT PITTSBURGHHigh-Content Cell-Based Screening for Modulators of Autophagy
YUAN, JUNYINGHARVARD UNIVERSITY (MEDICAL SCHOOL)A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway
ZHENG, WEIU.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTEHTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors
ZHENG, WEIU.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTEHTS for Identification of Inhibitors Against the ERK Signaling Pathway using a Ho

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147
PAR-06-259
PI NameInstitution NameTitle
DE FIGUEIREDO, PAULTEXAS A&M UNIVERSITY SYSTEMDrug Discovery for Bone Marrow Failure Diseases
FRANK, DAVID ADANA-FARBER CANCER INSTITUTEModulators of STAT transcription factors for the targeted therapy of cancer
GRIFFIN, PATRICK RSCRIPPS RESEARCH INSTITUTEHTRF screen for identifying SRC-1 selective agonists of PPARgamma
GU, HOWARD HOHIO STATE UNIVERSITYHigh Throughput Screening for Cocaine Antagonists
KUHN, PETERSCRIPPS RESEARCH INSTITUTEEphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition
LIOU, HSIOU-CHIIMMUNETARGET, INC.Development of Screening Assays for NF-KB-Rel Inhibitors
MARTINEZ, ELISABETH DUNIVERSITY OF TEXAS SW MED CTR/DALLASHigh Throughput Screens for Epigenetic Modulators
MERCOLA, MARKBURNHAM INSTITUTE FOR MEDICAL RESEARCHScreen for Compounds that Promote Cardiomyocyte Cell Cycle Entry
NICHOLSON, BENJAMINPROGENRA, INC.Identification of Compounds that Modulate Human Deubiquitinase Function
NIRENBERG, MARSHALL WARRENU.S. NATIONAL HEART LUNG & BLOOD INSMolecules that Enhance CREB Activity
QU, ZHICANSOUTHERN RESEARCH INSTITUTECell-Based Screening for Anti-Angiogenic Agents
REED, JOHN CBURNHAM INSTITUTE FOR MEDICAL RESEARCHHigh Throughput Screening Assay for Hsp70 Inhibitors
ROGERS, JACK TMASSACHUSETTS GENERAL HOSPITALMLSCN SCReen of the Amyloid precursor protein 5'untranslated region
SEIDAH, NABIL G.CLINICAL RESEARCH INSTITUTE OF MONTREALHigh Throughput Screens for targets of the Proprotein Convertases Furin, PC5, SKI-1 and PCSK9 Using Cell-Based Assays
SHOICHET, BRIAN K.UNIVERSITY OF CALIFORNIA SAN FRANCISCOPromiscuous and Specific Inhibitors of B-lactamase
SKLAR, LARRY A.UNIVERSITY OF NEW MEXICO ALBUQUERQUEHTS for BCI-2 Family Multiplex
SUN, YIUNIVERSITY OF MICHIGAN-ANN ARBORSynthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147
PAR-06-259
PI NameInstitution NameTitle
AULD, DOUGLAS SNIH/NHGRIIdentification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A
BRISSON, MARNI JUNIVERSITY OF PITTSBURGHHomogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase I
DESAI, SANJAY ANAT'L INST OF ALLERGY/INFEC DISEHigh-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC)
FIELDS, GREGG BFLORIDA ATLANTIC UNIVERSITYADAMTS/MMP Drug Development
GRESHAM, HATTIE DUNIVERSITY OF NEW MEXICO ALBUQUERQUESmall Molecule Inhibition of Staphylococcus Aureus Virulence
HAMMOCK, BRUCE DUNIVERSITY OF CALIFORNIA DAVISNovel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammat
HOFFMANN, MICHAELUNIVERSITY OF WISCONSINTargeting a Protein Interaction Site on Smad Transcription Factors
KATZENELLENBOGEN, JOHN AUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNScreen for Coactivator Binding Inhibitors to Block Estrogen Action
KELLY, JEFFERY WSCRIPPS RESEARCH INSTITUTEHigh Throughput Screening for Protein Misfolding Disease Therapeutics
LEYH, THOMAS S.YESHIVA UNIVERSITYScreening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae
MCPIKE, MARK PORTHOSYSTEMS, INC.Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery
PELLECCHIA, MAURIZIOBURNHAM INSTITUTEChemical Tools to Investigate the Protein Folding/Degradation Machinery
STRONGIN, ALEXBURNHAM INSTITUTEScreening Chemicals to Suppress MT1-MMP Synthesis in Cancer
THOMPSON, TODD AUNIVERSITY OF NEW MEXICO ALBUQUERQUEActivators of Prostate Cell Differentiation
WELLS, JAMES AUNIVERSITY OF CALIFORNIA SAN FRANCISCOInhibitors of Caspase-1 and Caspase-7
WILLIAMSON, JAMES RSCRIPPS RESEARCH INSTITUTEHigh Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction
YAFFE, MICHAELMASSACHUSETTS INST OF TECHNOLOHigh Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Lik
ZHENG, WEINIH/ NHGRIHTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmac

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (X01) Reissue of PAR-05-060
PAR-05-147
PI NameInstitution NameTitle
CONN, P JEFFREYVANDERBILT UNIVERSITYDiscovery of novel allosteric modulators of the M1 muscarinic receptor
HARSAY, EDINAUNIVERSITY OF KANSAS LAWRENCEChemical Genetics Screens to Identify Modulators of Post-Golgi Transport
KURET, JEFF AOHIO STATE UNIVERSITYLigands for premortem diagnosis and treatment of Alzheimer's disease
LEWIS, KIM ANORTHEASTERN UNIVERSITYA Screen for Novel Antimicrobials
LI, XIAOLINGORPHAGEN PHARMACEUTICALSHigh Throughput Screening of Select Orphan Nuclear Receptors
MCHENRY, CHARLES SUNIVERSITY OF COLORADO DENVER/HSC AURORAConducting a HTS against a Multi-protein DNA Replication System
MERCOLA, MARKBURNHAM INSTITUTEScreening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells
MERCOLA, MARKBURNHAM INSTITUTEScreening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells
MILLAN, JOSE LUISBURNHAM INSTITUTEPharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
MUSTELIN, TOMAS MBURNHAM INSTITUTEHTS for HePTP Inhibitors-a leukemia target
MUSTELIN, TOMAS MBURNHAM INSTITUTEHTS for LYP inhibitors-an autoimmunity target
NISWENDER, COLLEEN MVANDERBILT UNIVERSITYDiscovery of novel allosteric agonists of the M4 muscarinic receptor
PARNIAK, MICHAEL AUNIVERSITY OF PITTSBURGH AT PITTSBURGHHTS assays for inhibitors of HIV RNase H
PASQUALE, ELENA BBURNHAM INSTITUTEEphA4 Receptor Antagonists for Nervous System Repair
PAVITT, GRAHAM DUNIVERSITY OF MANCHESTER, UKHigh-throughput screen for a therapeutic agent for elF2B-related disorders
PIAZZA, GARY ASOUTHERN RESEARCH INSTITUTEIdentification of Molecular Probes that Reverse MRP-Mediated Drug Resistance
PROSSNITZ, ERIC RUNIVERSITY OF NEW MEXICO ALBUQUERQUEMLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors
PROSSNITZ, ERIC RUNIVERSITY OF NEW MEXICO ALBUQUERQUEMLSCN Assay for Inhibitors of Arrestin-GPR Interactions
REED, JOHN CBURNHAM INSTITUTEChemical Inhibitors of anti-apoptotic protein Bfl-1
REED, JOHN CBURNHAM INSTITUTEChemical inhibitors of antigen receptor-induced NF-?Beta activation
RUBENSTEIN, AMY LZYGOGEN, LLCZebrafish Lipid Metabolism Assay
SHARLOW, ELIZABETH R.UNIVERSITY OF PITTSBURGHFluroscence polarization assay for PLK1 inhibitors
SKLAR, LARRY AUNIVERSITY OF NEW MEXICO ALBUQUERQUEMLSCN Assay for Allosteric Ligands for the VLA-4 Integrin
SKOWYRA, DOROTAST. LOUIS UNIVERSITYATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for fl
STRONGIN, ALEX YBURNHAM INSTITUTEInhibitors of the NS3 Proteinase of West Nile and Dengue Viruses
STURGESS, MICHAEL ACHAPERONE TECHNOLOGIES, INC.Development of a HTS assay for Inhibitors of bacterial DnaK
WATTS, VAL JPURDUE UNIVERSITY WEST LAFAYETTEAllosteric Modulators of D1 Receptors
YI, FANGYALE UNIVERSITYIdentifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction usin

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (R03)
PAR-05-060
PI NameInstitution NameTitle
APPEL, BRUCEVANDERBILT UNIVERSITYA Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish
CHEN, BENJAMIN PUNIVERSITY OF TEXAS SW MED CTR/DALLASTRANSLATIONAL CONTROL OF RADIATION-INDUCED APOPTOSIS
CHENG, XIAODONGUNIVERSITY OF TEXAS MEDICAL BR GALVESTONChemical Genetic Screening of Oncogene RAS-Based Inhibitors
CHIOSIS, GABRIELASLOAN-KETTERING INSTITUTE FOR CANCER RESFP Assay for Isolation of Hsp90 Inhibitors
CHIOSIS, GABRIELASLOAN-KETTERING INSTITUTE FOR CANCER RESIsolation of Inhibitors of Her-Kinase Expression
DIAMOND, SCOTT LUNIVERSITY OF PENNSYLVANIAMultiplexed HTS of Serine and Cysteine Proteases
EDWARDS, BRUCEUNIVERSITY OF NEW MEXICO ALBUQUERQUEAssay for Formylpeptide Receptor Family Ligands
FU, HAIANEMORY UNIVERSITYAlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 Disruptors
GOLDFARB, DAVID SUNIVERSITY OF ROCHESTERYeast Lifespan Chemical Screening
LAZO, JOHN SUNIVERSITY OF PITTSBURGH AT PITTSBURGHChemical Complementation Assay for MKP-1
LAZO, JOHN SUNIVERSITY OF PITTSBURGH AT PITTSBURGHChemical Complementation Assay for MKP-3
LAZO, JOHN SUNIVERSITY OF PITTSBURGH AT PITTSBURGHIn Vitro High Throughput Screening Assay for MKP-1
LAZO, JOHN SUNIVERSITY OF PITTSBURGH AT PITTSBURGHIn Vitro High Throughput Screening Assay for MKP-3
MAYER, THOMASCOLUMBIA UNIVERSITY HEALTH SCIENCESCellular Assay for TNF Alpha Induced NF Kappa B Translocation
MAYER, THOMASCOLUMBIA UNIVERSITY HEALTH SCIENCESCellular Assay for TNF Alpha Induced E-Selectin Expression
MAYER, THOMASCOLUMBIA UNIVERSITY HEALTH SCIENCESCELLULAR ASSAY:PRESENTATION OF THE ADHESION MOLECUL
MUSTAEV, ARKADYPUBLIC HEALTH RESEARCH INSTITUTEDevelopment of the HTS Assay for E. Coli RNA Polymerase (RNAP)
NISWENDER, COLLEEN MVANDERBILT UNIVERSITYMeasurement of GPCR-mediated thallium flux through GIRK Channels
PAUMET, FABIENNECOLUMBIA UNIVERSITY HEALTH SCIENCESUnraveling the Molecular Mechanisms of Phagocytosis
ROTHMAN, JAMES ECOLUMBIA UNIVERSITY HEALTH SCIENCESAggregation and Clearance of Mutant Huntingtin
ROTHMAN, JAMES ECOLUMBIA UNIVERSITY HEALTH SCIENCESRegulation of Neurotransmitter Transporter Recycling
SANNA M. GERMANASCRIPPS RESEARCH INSTITUTEMLSCN HTS Assays R03 - S1P1
TEITLER, MILTALBANY MEDICAL COLLEGE OF UNION UNIVHuman 5HT 1E Serotonin Receptor Drug Development
WALKER, SUZANNEHARVARD UNIVERSITY (MEDICAL SCHOOL)Identification of O-GlcNAc Transferase Inhibitors by HTS
WHITE, E. LUCILESOUTHERN RESEARCH INSTITUTEHigh Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase
WILKINSON, KEITH DEMORY UNIVERSITYHTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme
WILLIAMS, DAVID LILLINOIS STATE UNIVERSITYHTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins
ZHOU, MINGCOLUMBIA UNIVERSITY HEALTH SCIENCESSmall-Molecule Modulators of a Family of Voltage-Dependent Potassium Channels

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Technology Development

Assay Development for High Throughput Molecular Screening (R21)
PAR-10-182
PI NameInstitution NameTitle
BRUICK, RICHARD K (contact)
HAMZA, IQBAL
UNIVERSITY OF TEXAS SW MED CTR/DALLASHigh Throughput Screen Development for Modulators of Heme Transporters
CARAVAN, PETER DMASSACHUSETTS GENERAL HOSPITALHigh throughput assay for fibrin-binding probes
CARSTENS, RUSS PAULUNIVERSITY OF PENNSYLVANIAHigh throughput assays for modulators of splicing switches during the EMT
CUNNINGHAM, KYLE WJOHNS HOPKINS UNIVERSITYAssays for Non-selective Cation Channel Inhibitors
DESHAIES, RAYMOND JCALIFORNIA INSTITUTE OF TECHNOLOGYA Screen for Inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases
GARDINER, DONALD L (contact)
BROWN, CHRISTOPHER LESLIE
MCCARTHY, JAMES STANISLAUS
TRENHOLME, KATHARINE RUTH
QUEENSLAND INSTITUTE OF MEDICAL RESEARCHAssay Development for lead identification of anti-gametocydial agents
GOLDBERG, ALFRED LHARVARD UNIVERSITY (MEDICAL SCHOOL)Assay Development for Screening of Specific IKK alpha Kinase Inhibitors
JARDETZKY, THEODORE SSTANFORD UNIVERSITYDevelopment of an IgE:Receptor Fluorescence Assay For High Throughput Screening
JOHNSTON, PAUL A.UNIVERSITY OF PITTSBURGH AT PITTSBURGHHCS Assay to Identify Disruptors of AR-TIF2 Protein-Protein Interactions
LUO, JUN-LISCRIPPS FLORIDAAssay Development for Screening of Specific IKK alpha Kinase Inhibitors
MARTINEZ-SOBRIDO, LUISUNIVERSITY OF ROCHESTERIdentification of compounds that activate interferon to treat viral infections
MERCOLA, MARKSANFORD-BURNHAM MEDICAL RESEARCH INSTITUTEHTS for inhibitors of RBPJ co-repressor complex
ROHATGI, RAJATSTANFORD UNIVERSITYHigh-throughput imaging of Hedgehog pathway components at the primary cilium
STROSBERG, ARTHUR DONNYSCRIPPS RESEARCH INSTITUTEDevelopment of a HTS assay to screen for inhibitors of HCV core NS3h interactions
SWANSTROM, RONALD I (contact)
JANZEN, WILLIAM PERRY
UNIVERSITY OF NORTH CAROLINA CHAPEL HILLHigh Throughput Screen For HIV-1 MA/CA Processing Site Inhibitors
WEAVER, C DAVIDVANDERBILT UNIVERSITYAn HTS-compatible Assay to Probe Muscarinic Receptor Modulation of the M current
ZHOU, PENGBOWEILL MEDICAL COLLEGE OF CORNELL UNIVDevelopment of high throughput assays to identify small molecule inhibitors of the CLR4 ubiquitin ligase

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Assay Development for High Throughput Molecular Screening (R21)
PAR-08-024
PI NameInstitution NameTitle
ADES, SARAH EPENNSYLVANIA STATE UNIVERSITY-UNIV PARKAssay Development for Inhibitors of the Essential sRNA-Sigma E Virulence Factors
ALDRICH, COURTNEY CUNIVERSITY OF MINNESOTA TWIN CITIESA Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
BALCH, WILLIAM EDWARD (Contact)
CONKRIGHT, JULIANA J
UNIV OF MASSACHUSETTS MED SCH WORCESTERHTS Approach to Correction of Alpha-1-Antitrypsin Misfolding Disease
BEINBORN, MARTINNEW ENGLAND MEDICAL CENTER HOSPITALSIdentification of Class B GPCR Modulators Using Hypersensitive Receptor Probes
BEREZOVSKA, OKSANAMASSACHUSETTS GENERAL HOSPITALDevelopment of a HTS assay for modulators of presenilin 1 conformation
BERG, LESLIE J (Contact);
ANDREOTTI, AMY;
KANG, JOONSOO
NEW ENGLAND MEDICAL CENTER HOSPITALSScreening for inhibitors of the T cell Tec Kinase (lTK)
BRAUTIGAN, DAVID LUNIVERSITY OF VIRGINIA CHARLOTTESVILLETriple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C
BRENMAN, JAY (contact)
SEXTON, JONATHAN ZACHARY
UNIVERSITY OF NORTH CAROLINA CHAPEL HILLHTS assay development to identify regulators of peroxisome biogenesis/function
BURANDA, TIONEUNIVERSITY OF NEW MEXICO HEALTH SCIS CTRDevelopment of HTS Assays for Inhibitors of Viral-Cell Interactions
BURRIS, THOMAS PSCRIPPS RESEARCH INSTITUTEDevelopment and Validation of a REV-ERBalpha HTS Assay
BURRIS, THOMAS PSCRIPPS RESEARCH INSTITUTEDevelopment of a High Throughput Screening Assay for RORgamma
BURRIS, THOMAS PSCRIPPS RESEARCH INSTITUTEDevelopment of an HTS assay to identify FXR antagonists
BUSHWELLER, JOHN HACKETTUNIVERSITY OF VIRGINIA CHARLOTTESVILLEScreening for Inhibitors for ERG in Prostate Cancer
CASTILLA, LUCIO HUNIV OF MASSACHUSETTS MED SCH WORCESTERIdentification of CBFB-MYH11 specific inhibitors for acute myeloid leukemia
CHAUDHARY, PREET MUNIVERSITY OF PITTSBURGH AT PITTSBURGHSmall Molecule Inhibitors of K13-Induced NF-kB Activation
CHEN, YUANCITY OF HOPE/BECKMAN RESEARCH INSTITUTEHigh Throughput Assays to Identify Inhibitors of SUMO-mediated Protein-Protein Interactions
CHENG, XIAODONGUNIVERSITY OF TEXAS MEDICAL BR GALVESTONHigh throughput assay for novel pharmacological probes Targeting cAMP signaling
CHO, CHARLES YOON-HYUNGNOVARTIS INST FOR FUNCTIONAL GENOMICSScreen for Small Molecule Regulators of Retinal Progenitor Epithelial Cell Phagocytosis
CHUANG, TSUNG-HSIENBURNHAM INSTITUTE FOR MEDICAL RESEARCHCell-based assay for high-throughput screening of TLR3 activators
CHUNG, WOOK JOONUNIVERSITY OF ALABAMA AT BIRMINGHAMA Novel HTS Cell-Based Imaging Assay to Identify Chemical Correctors for deltaF508-CFTR
CUI, LIWANGPENNSYLVANIA STATE UNIVERSITY-UNIV PARKDevelopment of a cell-based method for high-throughput drug screening in malaria
DEITERS, ALEXANDERNORTH CAROLINA STATE UNIVERSITY RALEIGHHigh-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
DENTON, JEROD SVANDERBILT UNIVERSITYChemical probes of the astroglial potassium channel Kir4.1
DIAMOND, SCOTT, (contact)
BLOBEL, GERD A
UNIVERSITY OF PENNSYLVANIADevelopment of a Cell-Based Screen for Inhibitors of the FOG-1-NuRD Interaction
DUERKSEN-HUGHES, PENELOPE JLOMA LINDA UNIVERSITYHTS Screening for Inhibitors of HPV 16 E6/Caspase 8 Binding
ENGEL, DANIEL A. (Contact)
BARIC, RALPH S
UNIVERSITY OF VIRGINIA CHARLOTTESVILLEYeast Based Assays for Chemical Screens Against SARS-CoV Target
ENGEL, JUAN CUNIVERSITY OF CALIFORNIA SAN FRANCISCOHTS assay for the intracellular stages of T. cruzi, the vector of Chagas disease
FABRIS, DANIELEUNIVERSITY OF MARYLAND BALT CO CAMPUSMS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interaction
FORD, JAMES MATTHEWSTANFORD UNIVERSITYA High-Throughput Assay for DNA Repair Activity in the Presence of Aberrant BRCA1
GARDNER, KEVIN H (Contact)
BRUICK, RICHARD K
UNIVERSITY OF TEXAS SW MED CTR/DALLASHigh Throughput Screen Development for Modulators of PAS/Coactivator Interactions
GILMOUR, BRIAN P.RESEARCH TRIANGLE INSTITUTEScreening Assay for Human TAAR1 Ligands
GOBER, JAMES WUNIVERSITY OF CALIFORNIA LOS ANGELESIdentification small molecule inhibitors of the bacterial morphogenetic complex
GOCHIN, MIRIAM DRTOURO UNIVERSITY OF CALIFORNIAAssay development for high affinity non-peptide HIV-1 gp41 inhibitors
HASLAM, DAVID B.WASHINGTON UNIVERSITYAn HTS Assay For Inhibitors Of C. Difficle Toxins
HODGSON, LOUISYESHIVA UNIVERSITYHigh Throughput Screening Assay of Cdc42 Activation in Cancer
HONKANEN, RICHARD EUNIVERSITY OF SOUTH ALABAMADevelopment of a HTS-assay for inhibitors of a type 2C protein phosphatase (PPMD1/WIP1)
JACKSON, MARYCOLORADO STATE UNIVERSITY-FORT COLLINSAssay Development of M. Tuberculosis Class II Aldolase
JIANG, ZHEN YUEBURNHAM INSTITUTE FOR MEDICAL RESEARCHHigh content screening assay for activators of glucose transporter GLUT4
JEGLA, TIMOTHY J.SCRIPPS RESEARCH INSTITUTEHTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels
KAISER, PETERUNIVERSITY OF CALIFORNIA IRVINEIdentification of Small Molecules for Reactivation of p53 Cancer Mutants
KAUFMAN, PAUL DUNIV OF MASSACHUSETTS MED SCH WORCESTERHTS development for targeted anti-fungal small molecules
KAYE, KENNETH MBRIGHAM AND WOMEN'S HOSPITALInhibitors of Kaposi’s Sarcoma Herpesvirus
KING, MICHAEL PTHOMAS JEFFERSON UNIVERSITYDevelopment of HTS assays for mitochondrial function
KRALLI, ANASTASIASCRIPPS RESEARCH INSTITUTEA HTS assay for agonists of the orphan nuclear receptor ERRg
LIEBERMAN, PAUL M.WISTAR INSTITUTEAssay Development for Inhibitors of KSHV
LIN, HENINGCORNELL UNIVERSITY ITHACAHigh-throughput assays for the development of SIRT5-specific inhibitors
LUO, MINKUISLOAN-KETTERING INSTITUTE FOR CANCER RESDeveloping High Throughput Assay to Identify Protein Methyltransferase Inhibitors
MADDEN, DEAN RDARTMOUTH COLLEGESmall-Molecule Targeting of CFTR:PDZ Trafficking Interactions
MAEGAWA, GUSTAVO HENRIQUE BOFFJOHNS HOPKINS UNIVERSITYA HTS assay to identify molecular probes for arylsulfatase A
MAITRA, RANGANRESEARCH TRIANGLE INSTITUTEHigh-throughput Assay to Identify CFTR Inhibitors
MARTIN, THOMAS F.UNIVERSITY OF WISCONSIN MADISONSCREENING FOR INHIBITORS OF VESICLE EXOCYTOSIS
MCDONALD, PATRICIA H.SCRIPPS RESEARCH INSTITUTEA novel approach to enable a HTS-compatible Galanin 3 receptor cell-based assay
MCNEIL, MICHAEL R.COLORADO STATE UNIVERSITY-FORT COLLINSHTS assay and configuration for inhibitors of the UDP-Mur formation pathway
MILLER, SAMUEL I.UNIVERSITY OF WASHINGTONAssay Development for High Throughput Molecular Screening
MUSSER, SIEGFRIED M.TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRHigh Throughput Screening for Tat Transport Inhibitors
NAPIERALA, MAREKUNIVERSITY OF TEXAS MD ANDERSON CAN CTRTargeting trinucleotide repeats-induced transcriptional silencing in Friedreich's Ataxia
NAPPER, ANDREWALFRED I. DU PONT HOSP FOR CHILDRENInhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
NEUBIG, RICHARD RUNIVERSITY OF MICHIGAN AT ANN ARBORAssay development for cellular RGS7 family modulators
PANDA, SATCHIDANANDASALK INSTITUTE FOR BIOLOGICAL STUDIESMelanopsin Photoactivation Assay
PASQUALE, ELENA BBURNHAM INSTITUTE FOR MEDICAL RESEARCHCell-based screening for EphA2 receptor inhibitors
PAULUS, HENRY (contact)
EMERSON, CHARLES P.
BOSTON BIOMEDICAL RESEARCH INSTITUTEIdentification of inhibitors of hedgehog autoprocessing
PETRUKHIN, KONSTANTINCOLUMBIA UNIVERSITY HEALTH SCIENCESDevelopment of the HTS assay for visual cycle inhibitors
PINTER, ABRAHAMUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOLHTS assays for reagents capable of unmasking conserved neutralization sites in HIV-1 Env
POTTER, JAMES DOUGLASUNIVERSITY OF MIAMI SCHOOL OF MEDICINEHTS for Regulated Muscle Thin Filament Function
PYLE, APRIL D.UNIVERSITY OF CALIFORNIA LOS ANGELESDevelopment of High Content Screens for Human Pluripotent Stem Cells
REITER, JEREMY F
ARKIN, MICHELLE R
UNIVERSITY OF CALIFORNIA SAN FRANCISCOA novel high content screen for regulators of ciliogenesis and Hedgehog signaling
ROGERS, JACK TMASSACHUSETTS GENERAL HOSPITALRNA Targeted Screens of the Prion 5'UTR
ROSEN, HUGHSCRIPPS RESEARCH INSTITUTEHTS for inhibitors of NADPH Oxidase 2 (NOX 2)
ROTH, GREGORYBURNHAM INSTITUTE FOR MEDICAL RESEARCHHTS to Identify Novel Chemical Probes for CCR6
SACKS, DAVID B.BRIGHAM AND WOMEN'S HOSPITALHigh throughput screen to identify inhibitors of Salmonella invasion
SATTERTHWAIT, ARNOLDBURNHAM INSTITUTE FOR MEDICAL RESEARCHDevelopment of HTS assays for Bcl-2 converters
SIBLEY, DAVID R.U.S. NATIONAL INST/NEURO/DS/STROKEFunctionally-selective ligands for the D2 dopamine receptor
SMITH, HAROLD COYAGEN, INC.Development of a High Throughput Screen for Antagonists of Vif Dimerization
STRANGE, KEVINVANDERBILT UNIVERSITYA high throughput screen for inhibitors of nematode detoxification genes
STROSBERG, ARTHUR DONNYSCRIPPS RESEARCH INSTITUTENovel Assay for Small Molecule Inhibitors of core-NS5A Interaction
SUZUKI, CAROLYN KUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOLHigh throughput screening assays to identify small molecules that target the ClpXP protease
TOBIAS, PETER SSCRIPPS RESEARCH INSTITUTEHigh Throughput Screening Assays to Identify Inhibitors of TLR4 Signaling
TOMASINI-JOHANSSON, BIANCAUNIVERSITY OF WISCONSIN MADISONModulators of Fibronectin Fibrillogenesis
TSE-DINH, YUK-CHINGNEW YORK MEDICAL COLLEGEHTS assay development targeting Yersinia pestis topoisomerase I
TURK, BENJAMIN EYALE UNIVERSITYIdentification of exosite-targeting inhibitors of anthrax lethal factor
WAGNER, ERIC JUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONAssay for Compounds that Elicit Misprocessing of Small Nuclear RNA
WAGNER, GERHARDHARVARD UNIVERSITY (MEDICAL SCHOOL)Assays for Discovery of Translation Inhibitors
WALKER, SUZANNE LHARVARD UNIVERSITY (MEDICAL SCHOOL)Cell-based HTS for Compounds that Block Virulence Factor Expression in MRSA
WALSH, KENNETH BUNIVERSITY OF SOUTH CAROLINA AT COLUMBIAReal Time Screening for GIRK1/4 Channel Blockers
WANDINGER-NESS, ANGELAUNIVERSITY OF NEW MEXICOHTS to identify small molecules that disrupt Rab GTPase activator and effector protein interactions
WANG, SHAOMENGUNIVERSITY OF MICHIGAN AT ANN ARBORDiscovery of small-molecule inhibitors of the Beta-Catenin / BCL-9 Interaction
WILLIAMS, RICHARD THOMASST. JUDE CHILDREN'S RESEARCH HOSPITALSynergy Screening of BCR-ABL-driven Lymphoid Leukemias
WOODARD, RONALD WESLEYUNIVERSITY OF MICHIGAN AT ANN ARBORMining the kds Pathways - New Source of Novel Antibacterial Targets
YAFFE, MICHAEL B (Contact)
FLOYD, SCOTT R
MASSACHUSETTS INSTITUTE OF TECHNOLOGYHigh-content screening for modifiers of the DNA damage response
YANG, PRISCILLA LI-NINGHARVARD UNIVERSITY (MEDICAL SCHOOL)Development of Cellular Assays of Dengue Virus Infection
ZHANG, QISHENGUNIVERSITY OF NORTH CAROLINA CHAPEL HILLHigh Throughput Assay Development for ARFGAP Modulators
ZHAO, RICHARD YUQIUNIVERSITY OF MARYLAND BALTIMOREFission Yeast as a HTS Platform for New Molecular Probes of HIV-1 VPR-Medicated A
ZHONG, TAO PVANDERBILT UNIVERSITYHigh content assay for zebrafish cardiomyocyte development
ZWEIFACH, ADAMUNIVERSITY OF CONNECTICUT STORRSA High-throughput Screen of Lytic Granule Exocytosis

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Assay Development for High Throughput Molecular Screening (R21) This is a reissue of RFA-RM-07-001
RFA-RM-07-008
PI NameInstitution NameTitle
ERNST, NANCY LEWISSEATTLE BIOMEDICAL RESEARCH INSTITUTEA High Throughput Assay to Identify Onhibitors of Trypanosome RNA Editing Ligase
FENG, XUUNIVERSITY OF ALABAMA AT BIRMINGHAMCell-Based Assays for Identifying Anti-RANK Signaling Agents
GRAEF, ISABELLA ASTANFORD UNIVERSITYHTS Assay Development for Modulators of a Nuclear Import/Export Switch
GRANNEMAN, JAMES GWAYNE STATE UNIVERSITYHTS for Novel Activators of Adipocyte and Myocyte Lipolysis
HARSAY, EDINAUNIVERSITY OF KANSAS LAWRENCEPathway-Specific Inhibitors of Post-Golgi Transport
HAZBUN, TONY (contact) 
DAVISSON, VINCENT JO
PURDUE UNIVERSITY WEST LAFAYETTEHigh-throughput Chemotyping of Yeast Signature Strains Reflecting Hsp90 Biology
ILAGAN, MA.XENIA GWASHINGTON UNIVERSITYScreening for Novel Modulators of Notch/RBPjk Interactions
JOHNSON, JEFFREY DALEMETABOLEX, INC.High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase
KAO, GARY DUNIVERSITY OF PENNSYLVANIAThe Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening
KAYE, KENNETH MBRIGHAM AND WOMEN'S HOSPITALChemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
KRANZ, ROBERT GWASHINGTON UNIVERSITYHTS for Cytochrome C Synthesis Pathways
MAITRA, RANGANRESEARCH TRIANGLE INSTITUTEAnti-inflammatory Assay for Cystic Fibrosis
NIKOLOV, DIMITAR BSLOAN-KETTERING INSTITUTE FOR CANCER RESNovel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
PETRIE, HOWARD TSCRIPPS RESEARCH INSTITUTEAssay Development and Screening for Notch Agonists
PETRUKHIN, KONSTANTINCOLUMBIA UNIVERSITY HEALTH SCIENCESDevelopment of the HTS Assay for Agonists of the Orphan Nuclear Receptor NR2E3
PRICE, BRENDAN DDANA-FARBER CANCER INSTITUTEIdentification of Inhibitors of the Tip60 Histone Acetyltransferase
REICHMAN, MELVINLANKENAU INSTITUTE FOR MEDICAL RESEARCHFructosamine-3-Kinase Assay Development and Validation for HTS
SALVESEN, GUY SBURNHAM INSTITUTE FOR MEDICAL RESEARCHDevelopment of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs]
WOLF, DIETER ABURNHAM INSTITUTE FOR MEDICAL RESEARCHOptimized High-Throughput Screen for Small Molecule Inhibitors of P27 Degradation
XU, BOSOUTHERN RESEARCH INSTITUTEAn HTS Assay for Inhibitors of NBS1-ATM Interactions
ZHOU, JIANHUAUNIV OF MASSACHUSETTS MED SCH WORCESTERCell Based Assays for Compounds That Regulate Tau Exon 10 Splicing

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Assay Development for High Throughput Molecular Screening (R21) Reissue of RFA-RM-06-004, which was previously released November 2, 2005 RFA-RM-05-011; Reissue for FY2005 of RFA-RM-04-012
RFA-RM-07-001
PI NameInstitution NameTitle
ARANY, ZOLTAN P.DANA-FARBER CANCER INSTITUTEHigh throughput screening for modulators of the transcriptional coactivator PGC-1
ARGON, YAIRCHILDREN'S HOSPITAL OF PHILADELPHIADeveloping HTS assays for the functions of the chaperone GRP94
BLENIS, JOHNHARVARD UNIVERSITY (MEDICAL SCHOOL)Development of a high content cell based screen for inhibitors of the mTOR signal
CLARDY, JONHARVARD UNIVERSITY (MEDICAL SCHOOL)Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
CLEARY, MICHAEL LqSTANFORD UNIVERSITYInhibitors of MLL-Menin Interaction
DUTTA, ANINDYAUNIVERSITY OF VIRGINIA CHARLOTTESVILLEScreen for TIP60 Inhibitors
FIDOCK, DAVID AYESHIVA UNIVERSITYA cell-based HTS for delayed death inhibitors of the malarial parasite plastid
GERACE, LARRY RSCRIPPS RESEARCH INSTITUTEScreen for Small Molecule Inhibitors of Nuclear Protein Import
GINSBERG, MARK HUNIVERSITY OF CALIFORNIA SAN FRANCISCOAssay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
GOCHIN, MIRIAMTOURO UNIVERSITY CALIFORNIAHigh-Throughput Screening for Human Immunodeficiency Virus Fusion Inhibitors
HARRIS, JASON BMASSACHUSETTS GENERAL HOSPITALDevelopment of a small molecule screen for PhoP regulon inhibitors in Salmonella
HODDER, PETER SIMMONSSCRIPPS RESEARCH INSTITUTEHTS assays for discovery of novel beta-lactamase inhibitors via click chemistry
HUANG, QIHONGWISTAR INSTITUTEA Cell-based Screen for Small Molecule Modulators of the miRNA Pathway
JAIN, ANJALICEDARS-SINAI MEDICAL CENTERFunctional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
JARDETZKY, THEODORE SNORTHWESTERN UNIVERSITYFunctional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
KAMPF, J PATRICKFFA SCIENCES, LLCAn HTS Assay for the Discovery of Specific Inhibitors of Adipocyte FABP
LAVAN, BRIANMETABOLEX, INC.High Throughput Screening for Identification of AKR1C3 Inhibitors
LI, RONGBAOSOUTHERN RESEARCH INSTITUTEHTS Assay Development for Discovery of Specific PYK2 Inhibitors
PETERSON, JEFFREY RINSTITUTE FOR CANCER RESEARCHAllosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1
PIAZZA, GARY ASOUTHERN RESEARCH INSTITUTEA Novel HTS Cell-Based Assay For Cyclic GMP
ROGERS, JACK TMASSACHUSETTS GENERAL HOSPITALMLSN Screen of the PD Alpha Synuclein 5'UTR
ROGERS, MICHAEL SCHILDREN'S HOSPITAL BOSTONAssay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1
RYDER, SEAN PATRICKUNIV OF MASSACHUSETTS MED SCH WORCESTERSmall molecule effectors of maternal gene expression in C. elegans embryogenesis
SANDER, CHRISSLOAN-KETTERING INSTITUTE FOR CANCER RESHigh-throughput identification of compounds that modulate the TGF-beta pathway
SMITH, LAYTON HBURNHAM INSTITUTE FOR MEDICAL RESEARCHHTS to identify chemical probes of the apelin receptor signaling pathway
WUTTKE, DEBORAH SUNIVERSITY OF COLORADO AT BOULDERDevelopment of a HTS Assay Targeting End Protection of Telomeres

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Assay Development for High Throughput Molecular Screening (R03/R21) Reissue for FY2006 of RFA-RM-05-011
RFA-RM-06-004
PI NameInstitution NameTitle
AGAISSE, HERVE FYALE UNIVERSITY SCHOOL OF MEDHigh-throughput screen for compounds affecting intracellular pathogen infection
AIKEN, CHRISTOPHER RVANDERBILT UNIVERSITYDiscovering Novel Inhibitors of HIV-1 Maturation
AYAD, NAGI GSCRIPPS FLORIDA RESEARCH INSTITUTESmall-molecule Inhibitors of Wee1 Degradation and Mitotic Entry
BALK, STEVEN PBETH ISRAEL DEACONESS MEDICAL CENTERHTS for Androgen Receptor Antagonists that Recruit NCoR
BOTTINI, NUNZIOLA JOLLA INST FOR ALLERGY & IMMUNOLGYFluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors
BROWN, STEVEN JSCRIPPS RESEARCH INSTITUTEDevelopment of a High Throughput Screening Galanin 3 Receptor Assay
CRAWFORD, BRETT EZACHARON PHARMACEUTICALS, INC.Development of cell-based assays for discovery of GIcNAc-TV inhibitors
CUNNINGHAM, KYLE WJOHNS HOPKINS UNIVERSITYAssays for compounds that block or stimulate yeast cell death
DAY, BILLY WUNIVERSITY OF PITTSBURGH AT PITTSBURGHHigh Throughput/Content Screens for Dynein Inhibitors
DELISA, MATTHEW PCORNELL UNIVERSITYA cell-based screen for inhibitors of intracellular Abeta aggregation
DENTON, JEROD SVANDERBILT UNIVERSITYIdentification of novel modulators of ROMK K+ channel activity
DESHMUKH, MOHANISH PUNIVERSITY OF NORTH CAROLINA CHAPEL HILLChemical Probes for Uncovering Differential Regulators of Apoptosis in Cells
DJABALLAH, HAKIMSLOAN-KETTERING INSTITUTE FOR CANCER RESNovel & Selective Small Molecular Inhibitors of Human Peptide Deformylase
HODGSON, LOUISUNIVERSITY OF NORTH CAROLINA CHAPEL HILLScreening for RhoC Activation and its modulation by GEFs
HOFFMANN, F. MICHAELUNIVERSITY OF WISCONSIN MADISONAn HTS Assay for Inhibitors of Smad-dependent Transcriptional Responses to TGF-beta
HOGENESCH, JOHN BUNIVERSITY OF PENNSYLVANIAA Dual Transcriptional and High Content Assay for Cryptochrome
HUGHES, ROBERT EBUCK INSTITUTE FOR AGE RESEARCHA cell-based screen for small molecule binders of mutant huntingtin messenger RNA
JEGLA, TIMOTHY JSCRIPPS RESEARCH INSTITUTEDevelopment of HTS Assays for Sub-Threshold Potassium Channels
JOHNSON, GARY LUNIVERSITY OF NORTH CAROLINA CHAPEL HILLInhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease
KHANNA, PYARE LDISCOVERX CORPORATIONHTS Technology for Discovery of Drugs Targeting GPCR Oligomers
LANDICK, ROBERT CUNIVERSITY OF WISCONSIN MADISONHigh-Throughput Identification of RNA polymerase inhibitors in vivo
LEISNER, TINA MUNIVERSITY OF NORTH CAROLINA CHAPEL HILLDeveloping HTS Assays for Novel Intracellular Regulators of Integrin Activation
LEVINE, FREDBURNHAM INSTITUTE FOR MEDICAL RESEARCHHigh-Throughput Screen for Beta-Cell Replication
LINDER, MAURINE EWASHINGTON UNIVERSITYAssay Development to Identify Palmitoylation Inhibitors of Neuronal Proteins
LUO, HONGBO RCHILDREN'S HOSPITAL BOSTONHigh throughput screening for inhibitors of Akt plasma membrane translocation.
MARZLUFF, WILLIAM FUNIVERSITY OF NORTH CAROLINA CHAPEL HILLScreen for molecules inhibiting histone pre-mRNA processing
MCNEIL, MICHAEL RCOLORADO STATE UNIVERSITY-FORT COLLINSGlucosamine-1-phosphate and serine acetylases: HTS assays and configurations
NETTLES, KENDALL WSCRIPPS RESEARCH INSTITUTEAssay Development for Identification of ER-NFkB Pathway Selective Agents
NEUBIG, RICHARD RUNIVERSITY OF MICHIGANMultiplexed flow cytometry screens for RGS inhibitors
NIKOLOVSKA-COLESKA, ZANETATHE UNIVERSITY OF MICHIGANDiscovery and characterization of novel small molecule inhibitors of Mcl-1
PADGETT, RICHARD ACLEVELAND CLINIC FOUNDATIONScreen for Small Molecule Inhibitors of Mammalian Spliceosomes
PERRIMON, NORBERTHARVARD UNIVERSITY (MEDICAL SCHOOL)High-throughput screening assay development for axonopathic neurodegeration
SALAVATI, REZAMCGILL UNIVERSITYRNA as the catalyst for screening drugs against trypanosomatids
THACHER, SCOTT MORPHAGEN PHARMACEUTICALSSmall Molecule Screen for Circadian and Metabolic Transcription Factors
TRAYNELIS, STEPHEN FEMORY UNIVERSITYIdentification of protease activated receptor-2 modulators
WAHLESTEDT, CLAESSCRIPPS RESEARCH INSTITUTEAssay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor
WEISS, ERIC LNORTHWESTERN UNIVERSITYDevelopment of a robust high throughput assay for the discovery of RAM network inhibitors
WELLS, JAMES AUNIVERSITY OF CALIFORNIA SAN FRANCISCOActivators of Procaspase-7
WESSLING-RESNICK, MARIANNEHARVARD UNIVERSITY (SCH OF PUBLIC HLTH)Fluorescence-based screen to probe hepcidin-ferroportin interactions
WILLIAMSON, JAMES RSCRIPPS RESEARCH INSTITUTEHTS for Discovery of Inhibitors of STAR Protein-RNA complexes
XIE, XINMIN SIMONSRI INTERNATIONALDevelopment of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR
ZHU, MICHAEL XOHIO STATE UNIVERSITYHigh throughput screening of ligands of TRP channels

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PI NameInstitution NameTitle
BACHER, ADELBERTTECHNICAL UNIVERSITY MUNICHHTS on Riboflavin and Terpene Biosynthetic Enzymes
CAFFREY, MICHAEL SUNIVERSITY OF ILLINOIS AT CHICAGOHigh Throughput Screening of HIV Entry Inhibitors
CARTEGNI, LUCASLOAN-KETTERING INSTITUTE FOR CANCER RESDevelopment of HTS Assays to Identify Specific Alternative Splicing Modulators
CHRISTENSEN, KENNETH ACLEMSON UNIVERSITYAssay for Molecules that Inhibit Anthrax Intoxication and Pathological Angiogenes
CLARDY, JON CHARVARD UNIVERSITY (MEDICAL SCHOOL)Phenotypic-based High Throughput Screens for Plasmodium Falciparum Malaria
CRAWFORD, BRETT EZACHARON PHARMACEUTICALS, INC.Cell-Based Screen for Inhibitors of Mucin-Type O-Linked Glycans
CUEVAS, BRUCE DUNIVERSITY OF NORTH CAROLINA CHAPEL HILLMEKK2/3-MEK5 Protein Interaction/Activation/ERK5 Pathway
DELPIRE, ERIC JVANDERBILT UNIVERSITYIdentification of Novel Modulators of CL-dependent Transport Processes via HTS
DEVI, LAKSHMI AMOUNT SINAI SCHOOL OF MEDICINE OF NYUAssay to Screen Ligands that Selectively Activate Opioid Receptor Heterodimers
ENGELMAN, DONALD MYALE UNIVERSITYA High Capacity Screen for Membrane-Active Compounds
GUPTA, VINEETMASSACHUSETTS GENERAL HOSPITALDeveloping HTS Assays for Discovery of Small Molecule Regulators of Integrins
JARSTFER, MICHAEL BUNIVERSITY OF NORTH CAROLINA CHAPEL HILLA High Throughput Screen for Telomerase Assembly
KAMPF, J PATRICKTORREY PINES INSTITUTE/MOLECULAR STUDIESA Fluorescent HTS Assay for the Discovery of FABP Binding Inhibitors
KAN, CHEN-CHENKECK GRADUATE INST OF APPLIED LIFE SCISHuman CD4+ T Cell Based High Throughput Assay for Drug-Resistant HIV-1 Proteases
KATZ, RICHARD AINSTITUTE FOR CANCER RESEARCHGFP-Based Assays to Probe Transcriptional and Post-Transcriptional Controls
KHANNA, PYARE LDISCOVERX CORPORATIONHTS Cell Based EFC Assays for GPCR Drug Discovery
LANSBURY, PETER TBRIGHAM AND WOMEN'S HOSPITALA High-Throughput Assay for SOD1 Aggregation Inhibitors
MARSH-ARMSTRONG, NICHOLAS RKENNEDY KRIEGER RESEARCH INSTITUTE, INC.Photoreceptor Degeneration Assay in Transgenic Xenopus Reporter Line
MCKERROW, JAMES HUNIVERSITY OF CALIFORNIA SAN FRANCISCOHigh Throughput Assay for Screening Compounds Against T. Brucei
MECSAS, JOAN CTUFTS UNIVERSITY BOSTONInhibitors of Yersinia Yop Type III Secretion and Translocation
MOHAN, ROYCEUNIVERSITY OF KENTUCKYNovel High Content Vascular Patterning Assay
MORRIS, DAVID GYALE UNIVERSITYHigh Throughput Molecular Screening for Compounds that Alter Tgfb1 Signaling Tgfb1 Signaling
NISWENDER, COLLEEN MVANDERBILT UNIVERSITYA Direct Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype
PASQUALE, ELENA BBURNHAM INSTITUTEEphA4 Receptor Antagonists for CNS Regeneration
ROGERS, JACK TMASSACHUSETTS GENERAL HOSPITALSmall HTS Molecules Targeting APP 5' Untranslated Region
SCHARENBERG, ANDREW MCHILDREN'S HOSPITAL AND REG MEDICAL CTRTRPM2 HTS Screening Assay Development
SCHMID, MOLLY BKECK GRADUATE INST OF APPLIED LIFE SCISGenetic-Based Whole Cell Assays for Discovery of Novel Antibacterials
SCHMIDT, WALTER KUNIVERSITY OF GEORGIAHTS-Based Identification of Novel Rce1p Inhibitors
SIDEROVSKI, DAVID PUNIVERSITY OF NORTH CAROLINA CHAPEL HILLReal-Time Fluorescence Assays of RGS Domain GAP Activity
SPERANDIO, VANESSAUNIVERSITY OF TEXAS SW MED CTR/DALLASScreen for Quorum Sensing Molecular Inhibitors
STIVERS, JAMES TJOHNS HOPKINS UNIVERSITYHigh Throughput Assay for Topoisomerase Enzyme Targets
STUDER, LORENZSLOAN-KETTERING INSTITUTE FOR CANCER RESHTS Screen for Neural Differentiation in Human ES Cells
SWAAN, PETER WUNIVERSITY OF MARYLAND BALT PROF SCHOOLHigh-Throughput Assay for the Intestinal Peptide Transporter
TRUBETSKOY, VLADIMIR SQUINTESSENCE BIOSCIENCESDevelopment of a Robust HTS Assay to Profile Glucuronidation of Small Molecules
WALDMAN, TODDGEORGETOWN UNIVERSITYIsogenic Cell-Based Screens for Cancer - Targeting Oncogenic B-Catenin
WEIS, KARSTENUNIVERSITY OF CALIFORNIA BERKELEYUsing Chemical Biology to Study the Small GTPase Ran
XIE, XINMIN SSRI INTERNATIONALDevelopment of HTS Assay for K(ATP) Channels Using FLIPR
YE, QI-ZHUANGINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISA Fluorescence Polarization Assay for Methyltransferases
ZACHARIAS, DAVID AUNIVERSITY OF FLORIDAA Cell-Based HT Imaging Assay for Palmitoylation

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High Throughput Molecular Screening Assay Development (R03)
RFA-RM-05-011
PI NameInstitution NameTitle
BEZPROZVANNY, ILYA BUNIVERSITY OF TEXAS SW MED CTR/DALLASScreen for blockers of a CaV2.2-Mint-PDZ1 association
BURGESS, RICHARD RUNIVERSITY OF WISCONSIN MADISONLRET-based HT Screening for Inhibitors of Transcription
BURNS, CHARLES GMASSACHUSETTS GENERAL HOSPITALHTS assay for zebrafish embryonic heart function
CHIOSIS, GABRIELASLOAN-KETTERING INSTITUTE FOR CANCER RESDevelopment of HTS assays probing Hsp90 inhibition
CHUNG, RAYMOND TMASSACHUSETTS GENERAL HOSPITALChemical Genetics to Identify Cellular Regulators of HCV
CLARDY, JON CHARVARD UNIVERSITY (MEDICAL SCHOOL)High-throughput Screens for P. falciparum Malaria
CONN, P JEFFREYVANDERBILT UNIVERSITYDevelopment of a High Throughput Assay for Allosteric P*
DAVID, SUNIL AUNIVERSITY OF KANSAS LAWRENCENovel High-throghput Assay for Angiogenesis Inhibitors
FENTON, ROBERT GUNIVERSITY OF MARYLAND BALT PROF SCHOOLHigh-throughput screen for inhibitors of Mcl-1
FRANK, DAVID ADANA-FARBER CANCER INSTITUTEHigh Throughput Screening for Modulators of STAT5
GOLDFARB, DAVID SUNIVERSITY OF ROCHESTERMolecular Screen for Lifespan Extension in Yeast
HARSAY, EDINAUNIVERSITY OF KANSAS LAWRENCEIdentifying compounds that target post-Golgi secretion
JAYARAMAN, VASANTHIUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONHigh throughout screening assay for glutamate receptors
KIEFF, ELLIOTT D.BRIGHAM AND WOMEN'S HOSPITALScreening of Epstein Barr Virus Replication
KIRKEN, ROBERT AUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONScreening for small molecule inhibitors of Stat5
KUTSCH, OLAFUNIVERSITY OF ALABAMA AT BIRMINGHAMA GFP Based HTS Assay for HIV-1 Tat Inhibitors
LITHGOW, GORDONBUCK INSTITUTE FOR AGE RESEARCHC. elegans, Aging and High Throughput Screening
LU, YILINGUNIVERSITY OF TEXAS MD ANDERSON CAN CTRTissue Lysate Arrays for Molecular Screening
MANION, MICHAEL KFRED HUTCHINSON CANCER RESEARCH CENTERMethods to identify BCL-2 ’gain of function“ inhibitors
MORISSEAU, CHRISTOPHE HPUNIVERSITY OF CALIFORNIA DAVISCyanohydrin based fluorescent substrates of sEH
PERRIMON, NORBERTHARVARD UNIVERSITY (MEDICAL SCHOOL)High-throughput screen for host factors in Listeria infection
ROSENFELD, STEVEN SCOLUMBIA UNIVERSITY HEALTH SCIENCESDevelopment of High Throughput Screening Assays to Targ*
THACHER, SCOTT MORPHAGEN PHARMACEUTICALSSmall Molecular Screen for Thymocyte Drug Target
TORTORELLA, DOMENICOMOUNT SINAI SCHOOL OF MEDICINE OF NYULuminescent assay to identify ER dislocation inhibitors
TSE-DINH, YUK-CHINGNEW YORK MEDICAL COLLEGEDevelopment of a HTS system in E. coli for topoisomeras*
WALDMAN, TODD AGEORGETOWN UNIVERSITYIsogenic Cell-Based Screens for Cancer: Targeting PTEN
WILSON, ROBERT BUNIVERSITY OF PENNSYLVANIAHigh throughput screen for cyclin D1 inhibitors
WRIGHT, KENNETH LH. LEE MOFFITT CANCER CTR & RESEARCH INSHigh Throughput H3-K9 Methyltransferase Inhibitor Screen
XIE, SIMON XSRI INTERNATIONALHTS Assay for Ca 3 T-type Channels Using FLIPR
YAFFE, MICHAEL BMASSACHUSETTS INSTITUTE OF TECHNOLOGYHigh-Throughput Assay Design for Polo Kinase Inhibitors

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Exploratory Centers for Cheminformatics Research (P20)
RFA-RM-05-012
PI NameInstitution NameTitle
BRENEMAN, CURTIS MRENSSELAER POLYTECHNIC INSTITUTEEstablishment of the RPI Exploratory Center for Cheminformatics
CLEMONS, PAUL AMASSACHUSETTS INSTITUTE OF TECHNOLOGYGeneral Data-analysis Tools to Relate Chemical Diversity to Biological Outcomes
FOX, GEOFFREY CINDIANA UNIVERSITY BLOOMINGTONChemical Informatics Cyberinfrastructure
HUGHES-OLIVER, JACQUELINE MNORTH CAROLINA STATE UNIVERSITY RALEIGHComparative and Web-Enabled Virtual Screening
SHEDDEN, KERBYUNIVERSITY OF MICHIGAN AT ANN ARBORMACE - Michigan Alliance for Cheminformatic Exploration
TROPSHA, ALEXANDERUNIVERSITY OF NORTH CAROLINA CHAPEL HILLCarolina Exploratory Center for Cheminformatics Research

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Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41)
RFA-RM-09-007
PI NameInstitution NameTitle
AUBE, JEFFREYUNIVERSITY OF KANSAS LAWRENCEPilot Scale Libraries Inspired by Natural Products
DOEMLING, ALEXANDER SIEGFRIEDUNIVERSITY OF PITTSBURGH AT PITTSBURGHProtein protein interaction directed libraries
GUNATILAKA, LESLIEUNIVERSITY OF ARIZONADiverse Molecular Libraries from Unique Endosymbiotic Fungi
PHILLIPS, ANDREW JUNIVERSITY OF COLORADO AT BOULDERRobust New Chemistries for Heterocycles
SIGMAN, MATTHEW SUNIVERSITY OF UTAHDiscovery Based Studies of Medicinally Relevant Pharmacophore Libraries
WILLIAMS, PHILIPUNIVERSITY OF HAWAII AT MANOAAccessing Cyanobacterial Chemical Diversity: A Unique Natural Product Library

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New Methodologies for Natural Products Chemistry (R01)
RFA-RM-09-005
PI NameInstitution NameTitle
BACHMANN, BRIAN O (contact); MCLEAN, JOHN ALANVANDERBILT UNIVERSITYNew Methodologies for Accelerating Natural Product Discovery
CICHEWICZ, ROBERT HENRYUNIVERSITY OF OKLAHOMA NORMANAccessing Natural Products from Silent Biosynthetic Pathways
JENSEN, PAUL RUNIVERSITY OF CALIFORNIA SAN DIEGOA sequenced-based approach for improved small molecule discovery
SCHMIDT, ERIC WUNIVERSITY OF UTAHRapid Screening and Dereplication of Marine Symbiotic Natural Products
TANG, YIUNIVERSITY OF CALIFORNIA LOS ANGELESA Robust Platform for Reconstituting and Engineering Iterative Megasynthases

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Pilot-Scale Libraries for High-Throughput Screening (P41)
RFA-RM-06-003
PI NameInstitution NameTitle
BAURES, PAUL WILLIAMUNIVERSITY OF TULSAMolecular Libraries from Imidazole-4,5-Dicarboxylic Acid
GEORG, GUNDA IUNIVERSITY OF MINNESOTA TWIN CITIESLibraries for HTS: Privileged Structures in Sparsely Populated Chemical Space
GILBERTSON, SCOTT RUNIVERSITY OF TEXAS MEDICAL BR GALVESTONSynthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds
GRAY, NATHANAEL SDANA-FARBER CANCER INSTITUTEInhibitors of Kinase Activation
HOUGHTEN, RICHARD ATORREY PINES INST FOR MOLECULAR STUDIESStereochemically /Structurally Diverse Pilot Scale Libra
HOUGHTEN, RICHARD ATORREY PINES INST FOR MOLECULAR STUDIESHighly Diverse and Structurally Varied Heterocyclic Libraries for the MLSMR
KRCHNAK, VIKTORUNIVERSITY OF NOTRE DAMECombinational synthesis of bisheterocyclic libraries
KWON, OHYUNUNIVERSITY OF CALIFORNIA LOS ANGELESPilot-Scale Library Production Based on Phosphine Catalysis of Allenes
LAROCK, RICHARD CIOWA STATE UNIVERSITYHeterocyclic /Carbocyclic Libraries for High Throughput
PARKER, MATTHEW ACHEMDIV, INC.New Regions of Diversity Space in Ergot-Based Libraries
SCHROEDER, FRANK CLEMENSBOYCE THOMPSON INST FOR PLANT RESEARCHArthropod-Based Libraries for High Throughput Screening
SMITH, AMOS BUNIVERSITY OF PENNSYLVANIAPilot-Scale Libraries for High-throughput Screening (P41)
WEST, LYNDON MUNIVERSITY OF GEORGIA (UGA)“Drug-Like” Marine Natural Products Library
YU, MARVIN SFLUOROUS TECHNOLOGIES, INC.Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries

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Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41) This is a reissue of RFA-RM-05-014
RFA-RM-08-003
PI NameInstitution NameTitle
GILBERTSON, SCOTT RUNIVERSITY OF TEXAS MEDICAL BR GALVESTONPilot Scale Libraries Based on Biologically Active Scaffolds
HANSON, PAUL RUNIVERSITY OF KANSAS LAWRENCEProbing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK JUNIVERSITY OF CALIFORNIA DAVISComplex Heterocycles and Hybrid Strategies for Pilot Scale Libraries
LUESCH, HENDRIK (Contact)
PAUL, VALERIE J
UNIVERSITY OF FLORIDAPilot-Scale Libraries of Marine Cyanobacterial Natural Products
MARTIN, STEPHENUNIVERSITY OF TEXAS AUSTINGenerating Diverse Pilot-Scale Libraries for Screening
MOLANDER, GARY AUNIVERSITY OF PENNSYLVANIANovel Boronic Acids for Pilot-Scale Screening
REYNOLDS, ROBERT CSOUTHERN RESEARCH INSTITUTEPilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative
SCHAUS, SCOTT EDWARDBOSTON UNIVERSITYStructural and Sterochemically Diverse Heterocycles for the Small Molecule Reposi
SHEN, BENUNIVERSITY OF WISCONSIN MADISONNatural Products from Under-explored Microorganisms
TAN, DEREK SSLOAN-KETTERING INSTITUTE FOR CANCER RESDiversity-Oriented Synthesis of Natural Product-based Libraries for the MLSMR
WIPF, PETERUNIVERSITY OF PITTSBURGH AT PITTSBURGHNovel Heterocyclic Libraries
WRIGHT, AMY EFLORIDA ATLANTIC UNIVERSITYProduction of Pilot Scale Libraries of Marine Natural Products

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Pilot-Scale Libraries for High-Throughput Screening (P41)
RFA-RM-05-014
PI NameInstitution NameTitle
BURGESS, KEVINTEXAS A&M UNIVERSITY SYSTEMEvolving Libraries of Bivalent Compounds
HANSON, PAUL RUNIVERSITY OF KANSAS LAWRENCEProbing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK JUNIVERSITY OF CALIFORNIA DAVISUCD Combinatorial Center - Novel and Diverse Pilot-Scale Library Production
LEE, KUO-HSIUNGUNIVERSITY OF NORTH CAROLINA CHAPEL HILLCHEMICAL DIVERSITY LIBRARIES FROM MEDICINAL PLANTS
PORCO, JOHN ABOSTON UNIVERSITY CHARLES RIVER CAMPUSGeneration of Stereochemically and Structurally Complex Chemical Libraries
SCHREIBER, STUART LMASSACHUSETTS INSTITUTE OF TECHNOLOGYVersatile Diversity-oriented Small Molecule Libraries for Chemogenetics
TAN, DEREK SMEMORIAL SLOAN-KETTERING CANCER CENTERDiversity-Oriented Synthesis of Natural Product-based Libraries for the MLSCN
WRIGHT, JEFFREY LUNIVERSITY OF NORTH CAROLINA WILMINGTONDiverse Chemical Libraries from Photosynthetic Marine Microalgae

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New Methodologies for Natural Products Chemistry (R01) This is a reissue of RFA-RM-05-013
RFA-RM-08-004
PI NameInstitution NameTitle
CLARDY, JONHARVARD UNIVERSITY (MEDICAL SCHOOL)Molecule-to-gene approaches to new natural products
PETERS, REUBEN JIOWA STATE UNIVERSITYA Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids
ROMO, DANIELTEXAS A&M UNIVERSITY SYSTEMNew Methods for Simultaneous Arming and SAR Studies of Natural Products

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New Methodologies for Natural Products Chemistry (R01)
RFA-RM-05-013
PI NameInstitution NameTitle
BURKART, MICHAELUNIVERSITY OF CALIFORNIA SAN DIEGOProteomic Methodologies for Polyketide Biosynthesis
DOYLE, DONALD FGEORGIA INSTITUTE OF TECHNOLOGYNatural Product Biosynthesis by Chemical Complementation
HANDELSMAN, JO EUNIVERSITY OF WISCONSIN MADISONIntracellular Screens for Discovery of Natural Products in Metagenomic Libraries
MILLER, MARVIN JUNIVERSITY OF NOTRE DAMENovel Derivatization/Functionalization of Natural Products
ORJALA, JIMMYUNIVERSITY OF ILLINOIS AT CHICAGOMicroscale LC-MS and NMR Methodology for Rapid Natural Products Chemistry
WANG, CLAY CUNIVERSITY OF SOUTHERN CALIFORNIA

Platforms for Nonribosomal Peptide Manipulation

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Molecular Libraries Screening Instrumentation (R01)
RFA-RM-08-020
PI NameInstitution NameTitle
EDWARDS, BRUCE S.UNIVERSITY OF NEW MEXICOAdvancing High Throughput Flow Cytometry

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Molecular Libraries Screening Instrumentation (R01)
RFA-RM-04-020
PI NameInstitution NameTitle
GASCOYNE, PETER RUNIVERSITY OF TEXAS MD ANDERSON CANCER CENTERReconfigurable microfluidic assay platform for molecular Library Screening
KRON, STEPHEN JUNIVERSITY OF CHICAGOMolecular Library Screening By MALDI-TOF Scanning of Functional Peptide Arrays
LARSON, DALE NHARVARD UNIVERSITY (MEDICAL SCHOOL)HTS of Small Molecule-Protein Interactions
LITVINOV, DMITRIUNIVERSITY OF HOUSTONDevelopment of Nanomagnetic Sensor Array For High Throughput Molecular Screening
MA, HAICHINGREACTION BIOLOGY CORPORATIONMicroarraying and Screening Chemical Libraries
PRICE, JEFFREY HBURNHAM INSTITUTEContinuous-Imaging HT Screening Instrument
VO-DINH, TUANDUKE UNIVERSITYUltra-High-Throughput Screening (uHTS) Based on Surface-Enhanced Raman Scattering
ZHU, XIANGDONGUNIVERSITY OF CALIFORNIA DAVISHigh-Speed Label-Free Optical Detection System for Small-Molecule Microarrays

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Novel Preclinical Tools for Predictive ADME-Toxicology (R21)
RFA-RM-04-023
PI NameInstitution NameTitle
BENET, LESLIE ZUNIVERSITY OF CALIFORNIA SAN FRANCISCOTransporter-Enzyme Interplay Evaluation via Microfluidic HTS Cell Culture Devices
GANEY, PATRICIA EMICHIGAN STATE UNIVERSITYGene Expression in Drug-inflammation Models as Predictive of Idiosyncratic ADRs
HAYSTEAD, TIMOTHY ADUKE UNIVERSITYProteome Mining as a Predicitve Tool of Drug Toxici ty
HOPFINGER, ANTON JCHEM21 GROUP, INC.Novel Descriptors and Informatics Methods for Predictive ADMET Modeling
MA, PETER XUNIVERSITY OF MICHIGAN AT ANN ARBORNano Fibers for ADME/Toxicology
MACDONALD, JEFFREY MUNIVERSITY OF NORTH CAROLINA CHAPEL HILLHuman Enterohepatic Cell Model for Predictive Toxicology
MACRAE, CALUM AMASSACHUSETTS GENERAL HOSPITALZebrafish Assays Predictive for Drug-Induced Cardiac Repolarization Toxicity PS-149
SUMNER, SUSAN JRESEARCH TRIANGLE INSTITUTEMetabolomics: Markers of Drug-Induced Liver Injury
TROPSHA, ALEXANDER EUNIVERSITY OF NORTH CAROLINA CHAPEL HILLRobust computational framework for predictive ADME-Tox Modeling
ZACHAREWSKI, TIMOTHY RMICHIGAN STATE UNIVERSITYHuman Stem Cells for Toxicity Screening

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Development of High Resolution Probes for Cellular Imaging

Innovation In Molecular Imaging Probes (R21)
RFA-RM-04-021
PI NameInstitution NameTitle
BOLSKAR, ROBERT DTDA RESEARCH, INC.Cut Nanotube Capsules for MR Imaging
BOPPART, STEPHEN AUNIVERSITY OF ILLINOIS URBANA-CHAMPAIGNMagnetomotive Optical Molecular Imaging Probes
BOYLE, TIMOTHY JSANDIA CORP-SANDIA NATIONAL LABORATORIESFlourescent Ceramic Nanoprobes
BULTE, JEFF WJOHNS HOPKINS UNIVERSITYDeveloping a CEST Reporter Gene
DAYTON, PAUL AUNIVERSITY OF CALIFORNIA DAVISHigh-Sensitivity Molecular Imaging with Ultrasound
DOUGLAS, TREVORMONTANA STATE UNIVERSITY (BOZEMAN)Targeted MRI with Protein Cage Architectures
GAO, JINMINGUNIVERSITY OF TEXAS SW MED CTR/DALLASMFe2O4-Loaded Polymer Micelles as Ultra-Sensitive MR Molecular Probes
HALPERN, HOWARD JUNIVERSITY OF CHICAGOMagnitude Improvement of Molecular Signaling Imaging
KURHANEWICZ, JOHNUNIVERSITY OF CALIFORNIA SAN FRANCISCOHyperpolarized 13c NMR Studies of Prostate Cancer
MACH, ROBERT HWASHINGTON UNIVERSITYRADIOLABELED PROBES FOR IMAGING CASPASE 3 ACTIVATION
MATTREY, ROBERT FUNIVERSITY OF CALIFORNIA SAN DIEGOMolecular Imaging with Ultrasound Contrast Agents
POMPER, MARTIN GJOHNS HOPKINS UNIVERSITYPSMA-based Gene Reporter-Probe System

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Development of High Resolution Probes for Cellular Imaging (P20)
RFA-RM-04-001
PI NameInstitution NameTitle
BURGESS, KEVINTEXAS A&M UNIVERSITY SYSTEMFluorescent Probes for Multiplexed Intracellular Imaging
DICKSON, ROBERT MGEORGIA INSTITUTE OF TECHNOLOGYSub-nm dendrimer-metal nanoclusters as ultrabright, mod*
MOERNER, WILLIAM ESTANFORD UNIVERSITYSingle-Molecule Fluorophores for Cellular Imaging
NIE, SHUMINGEMORY UNIVERSITYBioaffinity Nanoparticle Probes for Bioimaging
PISTON, DAVID WVANDERBILT UNIVERSITYProbes for Quantitative Optical and Electron Microscopy
SIMON, SANFORD MROCKEFELLER UNIVERSITYImaging single proteins in vivo with quantum dots
SINGER, ROBERT HYESHIVA UNIVERSITYLight-Activated Gene Expression in Single Cells
TING, ALICE YMASSACHUSETTS INSTITUTE OF TECHNOLOGYLibrary-based development of new optical imaging probes
TSIEN, ROGERUNIVERSITY OF CALIFORNIA SAN DIEGOGenetically Targetable Labels For Light and EM

This page last reviewed on January 31, 2024