Once thought to exist only within cells, RNA is now known to be exported from cells and play a role in newly discovered mechanisms of cell-to-cell communication. The Common Fund’s Extracellular RNA Communication (ERC) program aims to discover fundamental biological principles about the mechanisms of extracellular RNA (exRNA) generation, secretion, and transport; to identify and develop a catalogue of exRNA in normal human body fluids; and to investigate the potential for using exRNAs as therapeutic molecules or biomarkers of disease.
NIH has announced a new funding opportunity that is related to, but separate from, the Common Fund's Extracellular RNA Communication program.
Extracellular RNA Shows Promise in Treating Multiple Sclerosis and Other Neurological Conditions
Dr. Richard Kraig and colleagues are exploring how extracellular microRNAs could be used as a novel therapeutic for multiple sclerosis and other demyelinating diseases.