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Funded Research

The Regulatory Science Program has transitioned from Common Fund support. For more information please visit https://commonfund.nih.gov/regulatoryscience.

Please note that since the Regulatory Science program is no longer being supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis.

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) FA-RM-11-022
PI NameInstitution NameTitle
GEORGE, STEVEN CARLUNIVERSITY OF CALIFORNIA IRVINEAn integrated in vitro model of perfused tumor and cardiac tissue
GRIFFITH, LINDA GMASSACHUSETTS INST OF TECHAll-Human Microphysical Model of Metastasis Therapy
HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.
UNIVERSITY OF CALIFORNIA BERKELEYDisease-Specific Integrated Microphysiological Human Tissue Models
HIMMELFARB, JONATHANUNIVERSITY OF WASHINGTONA Tissue Engineered Human Kidney Microphysiological System
PARKER, KEVIN KITHARVARD UNIVERSITYHuman Cardio-Pulmonary System on a Chip
TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L
MASSACHUSETTS GENERAL HOSPITALA 3D biomimetic liver sinusoid construct for predicting physiology and toxicity
THOMSON, JAMES ALEXANDERMORGRIDGE INSTITUTE FOR RESEARCHHuman iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity
TRUSKEY, GEORGE ADUKE UNIVERSITYCirculatory system and integrated muscle tissue for drug and tissue toxicity
VUNJAK-NOVAKOVIC, GORDANACOLUMBIA UNIV NEW YORK MORNINGSIDEIntegrated heart-liver-vascular systems for drug testing in human health and dise
WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J
VANDERBILT UNIVERSITYNeurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses
WOODRUFF, TERESA KNORTHWESTERN UNIVERSITY AT CHICAGOEx Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System

 

Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3) RFA-TR-12-004
PI NameInstitution NameTitle
AKHLAGHI, FATEMEH (contact)
LEGGIO, LORENZO
UNIVERSITY OF RHODE ISLANDA Novel Compound for Alcoholism Treatment: a Translational Strategy
BREIER, ALANINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISThe Efficacy and Safety of a Selective Estrogen Receptor Beta agonist (LY500307)
BRUNZELL, DARLENE H (contact)
PERKINS, KENNETH ALAN
VIRGINIA COMMONWEALTH UNIVERSITYMedication development of a novel therapeutic for smoking cessation
EISSA, TONYBAYLOR COLLEGE OF MEDICINETherapeutic Strategy for LAM (Lymphangioleiomyomatosis)
KRYSTAL, JOHN HYALE UNIVERSITYTranslational Neuroscience Optimization of GlyT1 Inhibitor
MILLER, JORDAN D (contact)
ENRIQUEZ-SARANO, MAURICE
SCHAFF, HARTZELL V.
MAYO CLINIC ROCHESTERTherapeutic Strategy to slow progression of calcific aortic valve stenosis
STRITTMATTER, STEPHEN M (contact)
NYGAARD, HAAKON BERGE
VAN DYCK, CHRISTOPHER H
YALE UNIVERSITYFyn Inhibition by AZD0530 for Alzheimers Disease
WAGNER, KATHRYN R (contact)
FROEHNER, STANLEY C
HUGO W. MOSER RES INST KENNEDY KRIEGERPartnering to treat an Orphan Disease Duchenne Muscular Dystrophy

 

Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH3) RFA-TR-12-005
PI NameInstitution NameTitle
ANNEX, BRIAN HUNIVERSITY OF VIRGINIAReuse of ZD4054 for patients with symptomatic PAD

 

Stem/Progenitor Cell-Derived Human Micro-organs and -tissues (U18) RFA-RM-12-001
PI NameInstitution NameTitle
CHRISTIANO, ANGELA MCOLUMBIA UNIVERSITY HEALTH SCIENCESModeling complex diseases using iPSC-derived skin constructs
DONOWITZ, MARKJOHNS HOPKINS UNIVERSITYHuman Intestinal Organoids: Pre-Clinical Models of Non-Inflammatory Diarrhea
HARTUNG, THOMASJOHNS HOPKINS UNIVERSITYA 3D Model of Human Brain Development for Studying Gene/Environment Interactions
LYNCH, JOHN PUNIVERSITY OF PENNSYLVANIAModeling oxidative stress and DNA damage using GI organotypic culture systems
NICHOLS, JOAN EUNIVERSITY OF TEXAS MEDICAL BR GALVESTON3D human lung model to study lung disease and formation of fibrosis
TUAN, ROCKY SUNIVERSITY OF PITTSBURGH3-D Osteochondral Micro-tissue to Model Pathogenesis of Osteoarthritis
WELLS, JAMES MCINCINNATI CHILDRENS HOSPITAL MED CTRGenerating Human Intestinal Organoids with an ENS

 

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) RFA-RM-11-022
PI NameInstitution NameTitle
GEORGE, STEVEN CARLUNIVERSITY OF CALIFORNIA IRVINEAn integrated in vitro model of perfused tumor and cardiac tissue
GRIFFITH, LINDA GMASSACHUSETTS INST OF TECHAll-Human Microphysical Model of Metastasis Therapy
HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.
UNIVERSITY OF CALIFORNIA BERKELEYDisease-Specific Integrated Microphysiological Human Tissue Models
HIMMELFARB, JONATHANUNIVERSITY OF WASHINGTONA Tissue Engineered Human Kidney Microphysiological System
PARKER, KEVIN KITHARVARD UNIVERSITYHuman Cardio-Pulmonary System on a Chip
SHULER, MICHAEL L (contact)
HICKMAN, JAMES J
CORNELL UNIVERSITYMicrophysiologial systems and low cost microfluidic platform with analytics
TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L
MASSACHUSETTS GENERAL HOSPITALA 3D biomimetic liver sinusoid construct for predicting physiology and toxicity
THOMSON, JAMES ALEXANDERMORGRIDGE INSTITUTE FOR RESEARCHHuman iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity
TRUSKEY, GEORGE ADUKE UNIVERSITYCirculatory system and integrated muscle tissue for drug and tissue toxicity
VUNJAK-NOVAKOVIC, GORDANACOLUMBIA UNIV NEW YORK MORNINGSIDEIntegrated heart-liver-vascular systems for drug testing in human health and dise
WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J
VANDERBILT UNIVERSITYNeurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses
WOODRUFF, TERESA KNORTHWESTERN UNIVERSITY AT CHICAGOEx Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System

 

Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01)
RFA-RM-10-006
PI NameInstitution NameTitle
BARSAN, WILLIAM G (contact)
BERRY, DONALD A
LEWIS, ROGER J
UNIVERSITY OF MICHIGAN AT ANN ARBORAccelerating Drug and Device Evaluation through Innovative Clinical Trial Design
CERVEN, DANIEL R (contact)
DEGEORGE, GEORGE L.
MB RESEARCH LABORATORIES, INC.Replacement Ocular Battery (ROBatt)
HOURCADE, DENNIS E.WASHINGTON UNIVERSITYCharacterization/Bioinformatics-modeling of Nanoparticle: Complement Interactions
INGBER, DONALD EHARVARD UNIVERSITY (MEDICAL SCHOOL)Heart-Lung Micromachine for Safety and Efficacy Testing

This page last reviewed on January 17, 2024