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Funded Research

 

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) RFA-RM-11-022

PI Name Institution Name Title

GEORGE, STEVEN CARL

UNIVERSITY OF CALIFORNIA IRVINE

An integrated in vitro model of perfused tumor and cardiac tissue

GRIFFITH, LINDA G

MASSACHUSETTS INST OF TECH

All-Human Microphysical Model of Metastasis Therapy

HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.

UNIVERSITY OF CALIFORNIA BERKELEY

Disease-Specific Integrated Microphysiological Human Tissue Models

HIMMELFARB, JONATHAN

UNIVERSITY OF WASHINGTON

A Tissue Engineered Human Kidney Microphysiological System

PARKER, KEVIN KIT

HARVARD UNIVERSITY

Human Cardio-Pulmonary System on a Chip

TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L

MASSACHUSETTS GENERAL HOSPITAL

A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity

THOMSON, JAMES ALEXANDER

MORGRIDGE INSTITUTE FOR RESEARCH

Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity

TRUSKEY, GEORGE A

DUKE UNIVERSITY

Circulatory system and integrated muscle tissue for drug and tissue toxicity

VUNJAK-NOVAKOVIC, GORDANA COLUMBIA UNIV NEW YORK MORNINGSIDE Integrated heart-liver-vascular systems for drug testing in human health and dise

WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J

VANDERBILT UNIVERSITY

Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses

WOODRUFF, TERESA K NORTHWESTERN UNIVERSITY AT CHICAGO Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
 
 

Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3) RFA-TR-12-004

PI Name Institution Name Title

AKHLAGHI, FATEMEH (contact)
LEGGIO, LORENZO

UNIVERSITY OF RHODE ISLAND

A Novel Compound for Alcoholism Treatment: a Translational Strategy

BREIER, ALAN

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

The Efficacy and Safety of a Selective Estrogen Receptor Beta agonist (LY500307)

BRUNZELL, DARLENE H (contact)
PERKINS, KENNETH ALAN

VIRGINIA COMMONWEALTH UNIVERSITY

Medication development of a novel therapeutic for smoking cessation

EISSA, TONY

BAYLOR COLLEGE OF MEDICINE

Therapeutic Strategy for LAM (Lymphangioleiomyomatosis)

KRYSTAL, JOHN H

YALE UNIVERSITY

Translational Neuroscience Optimization of GlyT1 Inhibitor

MILLER, JORDAN D (contact)
ENRIQUEZ-SARANO, MAURICE
SCHAFF, HARTZELL V.

MAYO CLINIC ROCHESTER

Therapeutic Strategy to slow progression of calcific aortic valve stenosis

STRITTMATTER, STEPHEN M (contact)
NYGAARD, HAAKON BERGE
VAN DYCK, CHRISTOPHER H

YALE UNIVERSITY

Fyn Inhibition by AZD0530 for Alzheimers Disease

WAGNER, KATHRYN R (contact)
FROEHNER, STANLEY C

HUGO W. MOSER RES INST KENNEDY KRIEGER

Partnering to treat an Orphan Disease Duchenne Muscular Dystrophy

 

Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH3) RFA-TR-12-005

PI Name Institution Name Title

ANNEX, BRIAN H

UNIVERSITY OF VIRGINIA

Reuse of ZD4054 for patients with symptomatic PAD

 

Stem/Progenitor Cell-Derived Human Micro-organs and -tissues (U18) RFA-RM-12-001

PI Name Institution Name Title

CHRISTIANO, ANGELA M

COLUMBIA UNIVERSITY HEALTH SCIENCES

Modeling complex diseases using iPSC-derived skin constructs

DONOWITZ, MARK

JOHNS HOPKINS UNIVERSITY

Human Intestinal Organoids: Pre-Clinical Models of Non-Inflammatory Diarrhea

HARTUNG, THOMAS

JOHNS HOPKINS UNIVERSITY

A 3D Model of Human Brain Development for Studying Gene/Environment Interactions

LYNCH, JOHN P

UNIVERSITY OF PENNSYLVANIA

Modeling oxidative stress and DNA damage using GI organotypic culture systems

NICHOLS, JOAN E

UNIVERSITY OF TEXAS MEDICAL BR GALVESTON

3D human lung model to study lung disease and formation of fibrosis

TUAN, ROCKY S

UNIVERSITY OF PITTSBURGH

3-D Osteochondral Micro-tissue to Model Pathogenesis of Osteoarthritis

WELLS, JAMES M

CINCINNATI CHILDRENS HOSPITAL MED CTR

Generating Human Intestinal Organoids with an ENS

 

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) RFA-RM-11-022

PI Name Institution Name Title

GEORGE, STEVEN CARL

UNIVERSITY OF CALIFORNIA IRVINE

An integrated in vitro model of perfused tumor and cardiac tissue

GRIFFITH, LINDA G

MASSACHUSETTS INST OF TECH

All-Human Microphysical Model of Metastasis Therapy

HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.

UNIVERSITY OF CALIFORNIA BERKELEY

Disease-Specific Integrated Microphysiological Human Tissue Models

HIMMELFARB, JONATHAN

UNIVERSITY OF WASHINGTON

A Tissue Engineered Human Kidney Microphysiological System

PARKER, KEVIN KIT

HARVARD UNIVERSITY

Human Cardio-Pulmonary System on a Chip

SHULER, MICHAEL L (contact)
HICKMAN, JAMES J

CORNELL UNIVERSITY

Microphysiologial systems and low cost microfluidic platform with analytics

TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L

MASSACHUSETTS GENERAL HOSPITAL

A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity

THOMSON, JAMES ALEXANDER

MORGRIDGE INSTITUTE FOR RESEARCH

Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity

TRUSKEY, GEORGE A

DUKE UNIVERSITY

Circulatory system and integrated muscle tissue for drug and tissue toxicity

VUNJAK-NOVAKOVIC, GORDANA COLUMBIA UNIV NEW YORK MORNINGSIDE Integrated heart-liver-vascular systems for drug testing in human health and dise

WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J

VANDERBILT UNIVERSITY

Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses

WOODRUFF, TERESA K NORTHWESTERN UNIVERSITY AT CHICAGO Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System

 

Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01)
RFA-RM-10-006
PI Name Institution Name Title
BARSAN, WILLIAM G (contact)
BERRY, DONALD A
LEWIS, ROGER J
UNIVERSITY OF MICHIGAN AT ANN ARBOR Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design
CERVEN, DANIEL R (contact)
DEGEORGE, GEORGE L.
MB RESEARCH LABORATORIES, INC. Replacement Ocular Battery (ROBatt)
HOURCADE, DENNIS E. WASHINGTON UNIVERSITY Characterization/Bioinformatics-modeling of Nanoparticle: Complement Interactions
INGBER, DONALD E HARVARD UNIVERSITY (MEDICAL SCHOOL) Heart-Lung Micromachine for Safety and Efficacy Testing

 

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