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HRHR 2014 Symposium

NEW! You are invited to the HRHR 2014 Symposium being held December 15-17, 2014 in the Natcher Auditorium of the Natcher Conference Center, on the NIH campus. Register for the HRHR 2014 Symposium by November 24, 2014Exit Disclaimer

Learn more about the HRHR 2014 Symposium! Exit Disclaimer

Award Announcement

NEW! 2014 High Risk-High Reward Research Awards Announced!  

The NIH has announced 85 awards to support exceptional innovation in biomedical research. In 2014, the NIH is awarding 10 Pioneer Awards, 50 New Innovator Awards, 8 Transformative Research Awards, and 17 Early Independence Awards. The total funding, which represents contributions from the NIH Common Fund and multiple NIH institutes and centers, is approximately $141 million. Read the press release here.​

REST: The Difference between Destruction and Protection of the Brain 

Karl Deisseroth

The maintenance of cognitive ability during the aging process has become a significant medical challenge of our time. Alzheimer’s disease (AD), currently having no treatment, is one of the leading causes of death in the United States. A host of other neurodegenerative diseases cause a decline in mental ability that is capable of interfering with daily life. The reasons for the onset of these diseases are still being examined. Earlier studies suggest that neuronal loss was a normal consequence of brain aging; however, neuronal cells are preserved in the aging brain and decline only in the presence of neurodegenerative disease. Much of the research into the causes of diseases resulting in dementia has focused on the abnormal proteins that appear in the brains of people with neurodegenerative diseases; however some people with these abnormal protein clumps show little or no signs of cognitive decline. Why is it that some individuals, even those presenting dementia pathology, age with their cognitive function intact while others develop dementia? Read more here.

Archived Program Highlights..

Pioneer Award

Program Description

The NIH Director’s Pioneer Award program complements NIH’s traditional, investigator-initiated grant programs by supporting individual scientists of exceptional creativity, who propose pioneering – and possibly transforming approaches – to major challenges in biomedical and behavioral research. The term “pioneering” is used to describe highly innovative approaches that have the potential to produce an unusually high impact on a broad area of biomedical or behavioral research, and the term “award” is used to mean a grant for conducting research, rather than a reward for past achievements. To be considered pioneering, the proposed research must reflect ideas substantially different from those already being pursued in the investigator’s laboratory or elsewhere. Biomedical and behavioral research is defined broadly in this announcement as encompassing scientific investigations in the biological, behavioral, clinical, social, physical, chemical, computational, engineering, and mathematical sciences.

Awardees are required to commit the major portion (at least 51%) of their research effort to activities supported by the Pioneer Award. Investigators at all career levels are eligible, and those at early to middle stages of their careers and women and members of groups underrepresented in biomedical or behavioral research are especially encouraged to apply.


For more information about the Pioneer Award program, see the Frequently Asked Questions, or e-mail your questions to PioneerAwards@mail.nih.gov.

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