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​​Funded Research

2013 NIH Director’s Pioneer Award Program (DP1) RFA-RM-12-015

PI Name Institution Name Title

ARNSTEN, AMY F.T.

YALE UNIVERSITY

Highly evolved brain circuits in primates:  molecular vulnerabilities for disease

BOYDEN, EDWARD S.

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and Disease

GLADYSHEV, VADIM N.

BRIGHAM AND WOMEN'S HOSPITAL

Mechanisms of lifespan control

KHAKH, BALJIT

UNIVERSITY OF CALIFORNIA LOS ANGELES

Astrocyte branchlet dysfunction as an early step in brain disorders

LIN, MICHAEL Z.

STANFORD UNIVERSITY

Optogenetics for all: A general method for optical control of protein activity

SHENDURE, JAY ASHOK

UNIVERSITY OF WASHINGTON

Interpreting Genetic Variants of Uncertain Significance

TRAYANOVA, NATALIA A.

JOHNS HOPKINS UNIVERSITY

Virtual Electrophysiology Laboratory

WANG, FAN

DUKE UNIVERSITY

Toward causal neuroscience: capture and manipulate emergent neuronal ensembles

WEINBERGER, LEOR S.

J. DAVID GLADSTONE INSTITUTES

Evolvable Resistance-Proof Therapies

XIE, XIAOLIANG SUNNEY

HARVARD UNIVERSITY

Probing Dynamics of The Human Genome by Single Cell Sequencing

YUSTE, RAFAEL M.

COLUMBIA UNIV NEW YORK MORNINGSIDE

Functional connectomics of the neocortical microcircuit

ZYLKA, MARK J.

UNIV OF NORTH CAROLINA CHAPEL HILL

The Elongation Hypothesis of Autism

 

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2012 NIH Director’s Pioneer Award Program (DP1)
RFA-RM-11-004

PI Name Institution Name Title

BRUNET, ANNE

STANFORD UNIVERSITY

Transgenerational epigenetic inheritance of longevity

MARCOTTE, EDWARD M

UNIVERSITY OF TEXAS AUSTIN

Next-Generation Proteomics: Massively Parallel Single-Molecule Protein Identification & Quantification

PLOEGH, HIDDE L

WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

A new strategy to disrupt protein-protein interactions in eukaryotic cell

SMOLKE, CHRISTINA D

STANFORD UNIVERSITY

Synthetic Biology Platforms for Natural Product Discovery and Biosynthesis

TANG, YI

UNIVERSITY OF CALIFORNIA LOS ANGELES

Rediscovering Natural Chemical Diversity

TSAO, DORIS YING

CALIFORNIA INSTITUTE OF TECHNOLOGY

Understanding the circuit for topological object tracking

WANG, LIHONG

WASHINGTON UNIVERSITY IN ST. LOUIS

Photon Tunneling: Shedding new light on Biomedicine

WU, CHAO-TING

HARVARD UNIVERSITY

The inheritance of position: It's not just who you are, it's where you are

YELLEN, GARY I

HARVARD UNIVERSITY

Single cell analysis of metabolism using genetically-encoded fluorescent sensors

ZHANG, FENG

BROAD INSTITUTE, INC.

Probing Neuropsychiatric Diseases Using Targeted Epigenome and Genome Engineering

 

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2011 NIH Director’s Pioneer Award Program (DP1)
RFA-RM-10-008

PI Name Institution Name Title

BANERJEE, UTPAL

UNIVERSITY OF CALIFORNIA LOS ANGELES

Developmental Control of Metabolism

BASS, BRENDA L.

UNIVERSITY OF UTAH

Cellular double-stranded RNA as a signal of stress, immunity, and aging

BENNETT, JEAN

UNIVERSITY OF PENNSYLVANIA

Broad Spectrum Molecular Therapy for Blinding Retina Disorders

CLEMONS, WILLIAM M.

CALIFORNIA INSTITUTE OF TECHNOLOGY

NIH Pioneer Award

ENGERT, FLORIAN

HARVARD UNIVERSITY

Watching a vertebrate brain learn and behave in a virtual environment

FEINBERG, ANDREW P

JOHNS HOPKINS UNIVERSITY

A General Stochastic Epigenetic Model for Evolution, Development, and Disease

HILDRETH, JAMES E.K.

MEHARRY MEDICAL COLLEGE

Role of Natural Pseudotyping with Other Viruses in HIV Transmission

PAN, TAO

UNIVERSITY OF CHICAGO

Mis-translation as a new mechanism of stress response in biology

RAMANATHAN, SHARAD

HARVARD UNIVERSITY

A Road Map to the Neocortexs

SCHNEIDER, DAVID S

STANFORD UNIVERSITY

Mapping the road to recovery - Does the way we get better differ from the way we

SIAPAS, ATHANASSIOS G

CALIFORNIA INSTITUTE OF TECHNOLOGY

Nanoprobe arrays for massively parallel 3-D recordings of brain activity

TOLIAS, ANDREAS SAVAS

BAYLOR COLLEGE OF MEDICINE

Dissecting the Fabric of the Cerebral Cortex

YANIK, MEHMET FATIH

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Generating transplantable neurons by in vivo combinatorial screening of transcript

 

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2010 NIH Director’s Pioneer Award Program (DP1)
RFA-RM-09-010

PI Name Institution Name Title

BARBAS, CARLOS F

SCRIPPS RESEARCH INSTITUTE

Chemically Programmed Immunity

BJORKMAN, PAMELA J

CALIFORNIA INSTITUTE OF TECHNOLOGY

Thwarting HIV evasion of antibody avidity with novel antibody architectures

DRAGOI, VALENTIN

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

Examining Population Coding Underlying Complex Behavior in Freely Moving Primates

FESIK, STEPHEN W

VANDERBILT UNIVERSITY MEDICAL CENTER

Expanding the druggable genome

HORVATH, TAMAS L

YALE UNIVERSITY

Hypothalamic AgRP neurons are determinants of healthy lifespan and higher brain f

JOUNG, J. KEITH

MASSACHUSETTS GENERAL HOSPITAL

Advancing stem cell technologies using engineered zinc finger proteins

KLEINFELD, DAVID

UNIVERSITY OF CALIFORNIA SAN DIEGO

Defining the Logic of Neurovascular Signaling in the Brain

LIN, HAIFAN

YALE UNIVERSITY

Toward a Central Question in Epigenetics: A Major Epigenetic Programming Mechanis

LIU, JUN O

JOHNS HOPKINS UNIVERSITY

Generation and Proteome-Wide Screening of Hybrid Combinatorial Libraries

MARICQ, ANDRES VILLU

UNIVERSITY OF UTAH

Simultaneous in vivo studies of synapses, neurons, and learning and memory

NADEAU, JOSEPH H

CASE WESTERN RESERVE UNIVERSITY

Lamarck Redux: Transgenerational genetic effects on phenotypes and disease

NICOLELIS, MIGUEL A. L.

DUKE UNIVERSITY

A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating Technologies

RAMAKRISHNAN, LALITA

UNIVERSITY OF WASHINGTON

Linking the behavior of individual host cells to their transcriptional signatures

ROLE, LORNA W

THE RESEARCH FOUNDATION OF SUNY

Unveiling the role and taking control of Cholinergic Tone in circuits of attentio

ROUKES, MICHAEL L

CALIFORNIA INSTITUTE OF TECHNOLOGY

Nanoscale Tools to Push Biomedical Frontiers

SAMUDRALA, RAM

UNIVERSITY OF WASHINGTON

NOVEL PARADIGMS FOR DRUG DISCOVERY: COMPUTATIONAL MULTITARGET SCREENING

YANKNER, BRUCE A

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Modeling the Aging Epigenome

 

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2009 NIH Director’s Pioneer Award Program (DP1)
RFA-RM 09-001
PI Name Institution Name Title
BENJAMIN, IVOR J UNIVERSITY OF UTAH Protein Misfolding Diseases and Oxido-Reductive Pathways
CHAWLA, AJAY STANFORD UNIVERSITY Immune Triggers of Tissue Regeneration
CHEN, CHANG-ZHENG STANFORD UNIVERSITY The Role of Pre-miRNA Loop in Target Regulation by microRNA Genes
CHEROUTRE, HILDE LA JOLLA INST FOR ALLERGY & IMMUNOLOGY Uncovering the Missing Link that Determines Susceptibility to Autoimmunity
COVERT, MARKUS W STANFORD UNIVERSITY A Gene-Complete Computational Model of Yeast
DESIMONE, JOSEPH M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Delivery of Biological Therapeutics: Using Engineered Particles and Novel Deliver
EVANS, SYLVIA M UNIVERSITY OF CALIFORNIA SAN DIEGO Approaches to Cardiac Regeneration
FETCHO, JOSEPH R. CORNELL UNIVERSITY ITHACA Global changes in synaptic strength and excitability during sleep and wakefulness
HOLY, TIMOTHY E WASHINGTON UNIVERSITY WATCHING ACTION POTENTIALS IN INTACT NEURONAL CIRCUITS
REYA, TANNISHTHA DUKE UNIVERSITY Imaging self-renewal and transformation in hematopoietic stem cells
ROBINSON, GENE E UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System
ROSENBERG, SUSAN M BAYLOR COLLEGE OF MEDICINE Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes
SAMSON, LEONA D MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing novel methods to measure DNA repair capacity in human populations
SHAH, NIRAO M UNIVERSITY OF CALIFORNIA SAN FRANCISCO Dissecting the neural control of social attachment
SHENOY, KRISHNA V STANFORD UNIVERSITY Toward an Animal Model of Freely Moving Human
TISHKOFF, SARAH UNIVERSITY OF PENNSYLVANIA African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits
TRAVIS, ALEXANDER J CORNELL UNIVERSITY ITHACA Nanoscale energy production for implantable medical devices
ZHANG, JIN JOHNS HOPKINS UNIVERSITY Creating a Genetically Encodable Nano-Compass to Navigate in Molecular Networks

 

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2008 ​NIH Director's Pioneer Award Program (DP1)
RFA-RM-08-013
PI Name Institution Name Title
CHEN, JAMES K STANFORD UNIVERSITY Chemical Embryology: Technologies for Manipulating and Visualizing Development
DOLMETSCH, RICARDO E STANFORD UNIVERSITY Using induced pluripotent stem cells to identify the cellular phenotypes of autis
EBERWINE, JAMES H UNIVERSITY OF PENNSYLVANIA Cellular logic of phenotype
EPSTEIN, JOSHUA M BROOKINGS INSTITUTION CENTER Behavioral Epidemiology: Applications of Agent-Based Modeling to Infectious Diseases
HAY, BRUCE A CALIFORNIA INSTITUTE OF TECHNOLOGY Engineering the genetics of wild mosquito populations to fight infectious disease
HOCHSCHILD, ANN HARVARD MEDICAL SCHOOL A new genetic approach for studying prions and other pathogenic protein aggregate
LIEBER, CHARLES M HARVARD UNIVERSITY Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials
LONDON, BARRY UNIVERSITY OF PITTSBURGH In-Vivo Electrophysiology Imaging
MANIATIS, THOMAS P HARVARD UNIVERSITY Use of induced pluripotent stem cells to study mechanims of familial and sporadic
ODOM, TERI WANG NORTHWESTERN UNIVERSITY Reconstructing Sub-cellular Structure using Plasmonic Metamaterials
PARK, HONGKUN HARVARD UNIVERSITY Nano- and Microelectronic Tools for Interrogating Neuronal Circuits and Networks
REGEV, AVIV MASSACHUSETTS INST OF TECHNOLOGY
BROAD INSTITUTE
The temporal reconfiguration of regulatory networks: From yeast to cancer
SAMUEL, ARAVINTHAN D HARVARD UNIVERSITY Biophysical approaches to complex navigational behaviors in larval Drosophila mel
TAVAZOIE, SAEED F PRINCETON UNIVERSITY Towards a cognitive framework for understanding cellular behavior
TING, ALICE Y MASSACHUSETTS INST OF TECHNOLOGY Enabling the study of endogenous proteins in live cells
VAN OUDENAARDEN, ALEXANDER MASSACHUSETTS INST OF TECHNOLOGY Stochastic gene expression in differentiation and development

 

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2007 NIH Director's Pioneer Award Program (DP1)
RFA-RM-07-005
PI Name Institution Name Title
BARRETT, LISA FELDMAN TRUSTEES OF BOSTON COLLEGE Emotions are emergent events constrained by affective and conceptual processes.
BEARMAN, PETER COLUMBIA UNIV NEW YORK MORNINGSIDE Social Determinants of the Autism Epidemic
BROWN, EMERY NEAL MASSACHUSETTS GENERAL HOSPITAL A Systems Neuroscience for the Study of General Anesthesia
CLANDININ, THOMAS R STANFORD UNIVERSITY Dissecting the functional anatomy of the visual system: a new way forward
COLLINS, JAMES J TRUSTEES OF BOSTON UNIVERSITY A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms
GARDEL, MARGARET LISE THE UNIVERSITY OF CHICAGO 2007 NIH Director's Pioneer Award Program
HENSCH, TAKAO CHILDREN'S HOSPITAL CORPORATION Dissecting Non-coding RNA Function in Critical Period Brain Development and Disorders
HORWITZ, MARSHALL S UNIVERSITY OF WASHINGTON NIH Director's Pioneer Award
ISMAGILOV, RUSTEM F THE UNIVERSITY OF CHICAGO 2007 NIH Director's Pioneer Award Program
JENSEN, FRANCES E CHILDREN'S HOSPITAL CORPORATION Understanding the Cognitive Impact of Early Life Epilepsy
SCHNITZER, MARK J STANFORD UNIVERSITY Massively Parallel Brain Imaging
TURRIGIANO, GINA G BRANDEIS UNIVERSITY Probing the Structure of the Synapse Using Superresolution Light Microscopy

 

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2006 NIH Director's Pioneer Award Program (DP1)​
RFA-RM-06-005
PI Name Institution Name Title
BOAHEN, KWABENA STANFORD UNIVERSITY Neurogrid: Emulating a Million Neurons in the Cortex
CHAKRABORTY, ARUP K. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Developing the Principles Governing T Lymphocyte-Mediated Autoimmunity Using an Approach at an Intersection of the Physical and Life Sciences
GIERASCH, LILA M. UNIVERSITY OF MASSACHUSETTS AMHERST NIH Director's Pioneer Award Application
HEALD, REBECCA W. UNIVERSITY OF CALIFORNIA BERKELEY NIH Director's Pioneer Award Application
KIRKEGAARD, KARLA A STANFORD UNIVERSITY Dominant Drug Targets in RNA Viruses
KODADEK, THOMAS UNIVERSITY OF TEXAS SW MED CTR/DALLAS Novel Chemistry to Monitor and Manipulate the Immune System
LEE, CHENG C UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Reversible Suspended Animation of Non-hibernating Mammals
NUDLER, EVGENY NEW YORK UNIVERSITY SCHOOL OF MEDICINE New Approaches to Fight Infection
PIELAK, GARY J. UNIVERSITY OF NORTH CAROLINA CHAPEL HILL In-Cell NMR of Disease-Related Proteins
RELMAN, DAVID A STANFORD UNIVERSITY NIH Director's Pioneer Award Application
SEGAL, ROSALIND A. DANA-FARBER CANCER INSTITUTE An extended view of self: human indigenous microbial communities in health and disease
SHERLEY, JAMES L MASSACHUSETTS INSTITUTE OF TECHNOLOGY Pioneering Human Adult Stem Cell Discovery and Cellular Medicine
XIA, YOUNAN UNIVERSITY OF WASHINGTON Put Nanostructures to Work for Reading and Controlling Cell Behavior

 

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2005 NIH Director's Pioneer Award Program (DP1)
NOT-OD-05-021
PI Name Institution Name Title
CHANDLER, VICKI L UNIVERSITY OF ARIZONA NIH Director's Pioneer Award
CLINE, HOLLIS T COLD SPRING HARBOR LABORATORY NIH Director's Pioneer Award
COSMIDES, LEDA UNIVERSITY OF CALIFORNIA SANTA BARBARA NIH Director's Pioneer Award
DE LANGE, TITIA ROCKEFELLER UNIVERSITY NIH Director's Pioneer Award
DEISSEROTH, KARL A STANFORD UNIVERSITY NIH Director's Pioneer Award
HARBURY, PEHR A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award
JARVIS, ERICH D DUKE UNIVERSITY MEDICAL CENTER NIH Director's Pioneer Award
RANDO, THOMAS A STANFORD UNIVERSITY SCHOOL OF MEDICINE NIH Director's Pioneer Award
SMITH, DEREK J UNIVERSITY OF CAMBRIDGE NIH Director's Pioneer Award
TONONI, GIULIO UNIVERSITY OF WISCONSIN - MADISON MEDICAL SCHOOL NIH Director's Pioneer Award
WATERMAN-STORER, CLARE M. SCRIPPS RESEARCH INSTITUTE NIH Director's Pioneer Award
WOLFE, NATHAN JOHNS HOPKINS UNIVERSITY NIH Director's Pioneer Award
YUAN, JUNYING HARVARD MEDICAL SCHOOL NIH Director's Pioneer Award

 

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2004 NIH Director's Pioneer Award (DP1)
RFA-RM-04-500
PI Name Institution Name Title
ABBOTT, LARRY F. BRANDEIS UNIVERSITY NIH Director's Pioneer Award
DALEY, GEORGE Q CHILDREN'S HOSPITAL (BOSTON) NIH Director's Pioneer Award
HELLINGA, HOMME W. DUKE UNIVERSITY NIH Director's Pioneer Award
MCCUNE, JOSEPH M J. DAVID GLADSTONE INSTITUTES NIH Director's Pioneer Award
MCKNIGHT, STEVEN L UNIVERSITY OF TEXAS SW MED CTR/DALLAS NIH Director's Pioneer Award
MIRKIN, CHAD A NORTHWESTERN UNIVERSITY NIH Director's Pioneer Award
PHILLIPS, ROB CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Director's Pioneer Award
QUAKE, STEPHEN R CALIFORNIA INSTITUTE OF TECHNOLOGY NIH Director's Pioneer Award
XIE, SUNNEY HARVARD UNIVERSITY NIH Director's Pioneer Award
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