Kids First is Pleased to Announce New Cohort Data Available for Access

DNA sequence and clinical phenotype data for the “Discovery of the Genetic Basis of Structural Heart and Other Birth Defects”project (Accession Number: phs001138.v1.p2) are now available for access through NIH’s Database of Genotypes and Phenotypes (dbGaP).

This Kids First cohort selected for sequencing in 2015, is a sub-study of Pediatric Cardiac Genomics Consortium (PCGC) Study. This cohort was selected for further sequencing in 2016, and that data will be made available in the future. Researchers can visit the X01 projects page for the data release dates for each of the cohorts and the FAQs page for guidance on how to access the data. 


Gabriella Miller Kids First Pediatric Research Program will establish a New Pediatric Data Resource Center

The Kids First Program is establishing a Pediatric Data Resource Center in collaboration with The Center for Data Driven Discovery in Biomedicine at Children's Hospital of Philadelphia (CHOP) to allow researchers everywhere access to vast amounts of childhood cancer and structural birth defects genetics data. Read more https://d3b.center/kidsfirst/


Third Set of Childhood Cancer and Structural Birth Defect Patient Cohorts Announced

Kids First is pleased to announce the selection of a third set of childhood cancer and structural birth defects patient cohorts for whole genome sequencing. These patient cohorts will contribute to the forthcoming Kids First Data Resource which will allow scientists to identify genetic pathways that underlie these conditions and to explore whether shared genetic pathways exist between childhood cancer and structural birth defects. The applications were reviewed by a panel of external scientific experts and the selected cohorts address the following conditions:

The Kids First program will to call for applications to support whole genome sequencing of additional childhood cancer and structural birth defect cohorts in fiscal year 2018, pending availability of funds.


An FY15 X01 Project's Data is Now Publicly Available in dbGaP

In FY2015, Kids First selected the Genomic Analysis of Congenital Diaphragmatic Hernia cohort for whole genome sequencing. DNA sequence and clinical phenotype data for this project is now available in dbGap, and will be accessible through the forthcoming Kids First Data Resource. Until the Kids First Data Resource is completed researchers can visit the research projects page for the data release dates for each of the cohorts and the FAQs page for guidance on how to access the data.


Second Set of Childhood Cancer and Structural Birth Defect Patient Cohorts Announced

Kids First is excited to announce the selection of a second set of childhood cancer and structural birth defects patient cohorts for whole genome sequencing. These patient cohorts will contribute to the forthcoming Kids First Data Resource which will allow scientists to identify genetic pathways that underlie these conditions and to explore whether shared genetic pathways exist between childhood cancer and structural birth defects. The applications were reviewed by a panel of external scientific experts and the selected cohorts address the following conditions:

  • Cancers of the nerves that help control involuntary function (Neuroblastoma)
  • Cancers of the bone marrow that makes blood cells (Acute lymphoblastic leukemia and Hodgkin and non-Hodgkin lymphoma)
  • Diverse collection of Central Nervous System (CNS) and non-CNS solid tumors
  • Congenital Heart Defects
  • Developmental disorders of the chest muscle used for breathing (Congenital Diaphragmatic Hernia)
  • Cleft lip and cleft palate (Orofacial Cleft Birth Defects)
  • Congenital hearing loss
  • Abnormal curvature of the spine (adolescent idiopathic scoliosis)

Learn more about the 2015 and 2016 cohorts. The Kids First program plans to call for applications to support whole genome sequencing of additional childhood cancer and structural birth defect cohorts in fiscal years 2017-2018, pending availability of funds.


This page last reviewed on November 20, 2017