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Program Snapshot

The overall goal of the NIH HCS Research Collaboratory program is to strengthen the national capacity to implement cost-effective large-scale research studies that engage health care delivery organizations as research partners. The aim of the program is to provide a framework of implementation methods and best practices that will enable the participation of many health care systems in clinical research, not to support a defined health care research network. Research conducted in partnership with health care systems is essential to strengthen the relevance of research results to health practice.


Program Highlights

Visit the HCS Research Collaboratory website for in-depth program information.
NIH Collaboratory
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The STOP Colon Cancer Demonstration Project learned valuable lessons about promoting colon cancer screening among minority and low-income populations.
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Learn more about the project in the fun & educational video "Kids Say the Darndest Things: Now They're Talking About Colon Cancer" below.
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Kids Say the Darndest Things: Now They're Talking About Colon Cancer 

Collaboratory Researchers Find Poor Compliance with Clinical Trials Reporting Law. A new analysis of data from the ClinicalTrials.gov website shows that despite federal laws requiring the public reporting of results from clinical trials, most research sponsors fail to do so in a timely fashion—or, in many cases, at all. The study, published in the New England Journal of Medicine, was conducted by researchers supported by the NIH Collaboratory and the Clinical Trials Transformation Initiative (CTTI). A brief description of the findings is available in the Collaboratory's Living Textbook "Rethinking Clinical Trials." Exit Disclaimer The original research article was published in The New England Journal of Medicine. Exit Disclaimer

Ethical and Regulatory Challenges for Pragmatic Cluster Randomized Trials. A new report by researchers from the NIH Collaboratory explores some of the challenges facing physicians, scientists, and patient groups who are working to develop innovative methods for performing clinical trials. A brief description of the report is available in the Collaboratory's Living Textbook "Rethinking Clinical Trials." Exit Disclaimer The original research article was published in the journal Clinical Trials. Exit Disclaimer

"A guide to research partnerships for pragmatic clinical trials." The HCS Research Collaboratory's Systems Interactions Core just published a paper that highlights multiple lessons about building strong research partnerships between health researchers and healthcare systems. Read the full article in The BMJ. Exit Disclaimer Supplemental material is available in the Collaboratory's Living Textbook. Exit Disclaimer

Groundbreaking Suicide Study. One of the HCS Research Collaboratory Demonstration Projects is gearing up for a groundbreaking study that will help researchers learn more about ways to treat people experiencing suicidal thoughts. Nearly 20,000 patients will be able to participate in a trial that draws from other successful interventions for depression and suicide. Read the Science Update about this project from the National Institute of Mental Health.

An NIH-supported Viewpoint Essay in JAMA on the “ethical and regulatory complexities” that are the focus of current debate regarding the conduct of pragmatic clinical trials, trials that attempt to integrate research into the routine practice of clinical care.​
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NIH HCS Research Collaboratory


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