Program Snapshot

The Common Fund's Epigenomics Program has generated a set of reference epigenomes and new research tools, technologies, datasets, and infrastructure to accelerate our understanding of how genome-wide chemical modifications to DNA regulate gene activity without altering the DNA sequence itself and what role these modifications play in health and disease.

The Roadmap Epigenomics program issued its first round of awards in 2008. The program issued 77 awards and produced 111 reference maps of epigenomic modifications in a variety of healthy human cells and tissues, as well as other resources and tools that are extensively used by the biomedical research community. The Roadmap datasets are available through the Roadmap Epigenomics Mapping Consortium website and the Baylor Epigenome Atlas. The Roadmap Epigenomics program became a founding member of the International Human Epigenome Consortium (IHEC) in 2010. Roadmap Epigenomics awardees have published over 800 peer-reviewed articles. An integrative analysis paper, together with more than 20 companion papers, was published in a 2015 special edition of Nature. Program funding ended in 2017.

A Scientific Illustration of How Epigenetic Mechanisms Can Affect Health

Epigenomics Resources


This page last reviewed on August 14, 2018