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Funded Research

2023 NIH Director's Early Independence Award (DP5) - RFA-RM-22-021

*Diversity Statement

PI NameInstitution NameTitle
BENNETT, MARIKO LCHILDREN'S HOSP OF PHILADELPHIAUnlocking microglia targeting for neurotherapeutics
BERSHAD, ANYA KUNIVERSITY OF CALIFORNIA LOS ANGELESMDMA as a Treatment for Social Deficits in Schizophrenia
DHINDSA, RYAN BAYLOR COLLEGE OF MEDICINEIdentifying transcriptomic and epigenomic convergence in intellectual and developmental disorders 
FERENCZI, EMILY ANNEMASSACHUSETTS GENERAL HOSPITALDeciphering Neuronal Control of Behavioral Initiation and Suppression 
GBADAMOSI, MOHAMMED OLUSOJIUNIVERSITY OF FLORIDADecoding the Heterogeneity in Chemo-Immunomodulation to Unlock the Potential of Chemoimmunotherapy in Metastatic Triple-Negative Breast Cancer
GUEBLE, SUSAN EYALE UNIVERSITYTherapeutic Potential of a Novel MGMT-Dependent DNA Interstrand Crosslinking Agent in the Treatment of DNA Repair Deficient Cancer
KINNEBREW, MAIA STANFORD UNIVERSITYDeciphering the lipid composition of primary cilia in human metabolic disease
PINGLAY, SUDARSHAN UNIVERSITY OF WASHINGTONDissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencing
SEESE, RONALD ROBERTNORTHEAST OHIO MEDICAL UNIVERSITYDefining the Autonomic Cerebellum in Autism
SHANMUGAN, SHEILA UNIVERSITY OF PENNSYLVANIAUsing person-specific networks to uncover sex differences in vulnerability to internalizing disorders
SUSA, KATHERINE JULIAUNIVERSITY OF CALIFORNIA, SAN FRANCISCOIdentifying, Characterizing, and Targeting Regulators of B Cell Activation
THEODORIS, CHRISTINA VICKYJ. DAVID GLADSTONE INSTITUTESTransfer learning leveraging large-scale transcriptomics to map disrupted gene networks in cardiovascular disease
TSAI, JONATHAN MICHAELBRIGHAM AND WOMEN'S HOSPITALCharacterizing a Common Degradation Pathway for Nuclear Hormone Receptors

 

2022 NIH Director's Early Independence Award (DP5) - RFA-RM-21-018

*Diversity Statement

PI NameInstitution NameTitle
AMOR VEGAS, CORINACOLD SPRING HARBOR LABORATORYDeconstructing Aging with Senolytic CAR T Cells
BEEL, ANDREW JSTANFORD UNIVERSITYStructure and Pharmacologic Modulation of the Mitotic Chromosomes Central Axis
GITLIN, ALEXANDERSLOAN-KETTERING INST CAN RESEARCHRegulation of Proinflammatory Cytokine Responses by a Caspase-8-N4BP1 Axis
GRAJALES-REYES, GARY EWASHINGTON UNIVERSITY SAINT LOUISCAR-Based Approaches for the Treatment of Alzheimers Disease
HIURA, LISAUNIVERSITY OF COLORADOFunctional Ontogeny of Pair Bonding Neural Circuits
HOFFMANN, MAGNUS ADRIAN GEROCALIFORNIA INSTITUTE OF TECHNOLOGYSelf-Assembling Spike-EBR Nanoparticles as a Vaccine Platform Technology Against SARS-CoV-2 and Future Pandemic Coronaviruses.
LI, YUN ROSEBECKMAN RESEARCH INSTITUTE/CITY OF HOPEBiomarkers, Mechanisms and Modulation of Oxidative Stress Associated Risk Factors in Carcinogenesis
MILLER, DANNY ERWINUNIVERSITY OF WASHINGTONLong-Read DNA and RNA Sequencing to Identify Disease-Causing Genetic Variation and Streamline Testing
OCANAS, SARAH RENEEOKLAHOMA MEDICAL RESEARCH FOUNDATIONSex Chromosomal Regulation of Hippocampal Microglial Activation with Alzheimers Disease and Aging
PINNEY, MARGAUXUNIVERSITY OF CALIFORNIA, SAN FRANCISCOLeveraging Adaptive Evolution and High-Throughput Techniques to Dissect the Link Between Biochemical Function and Fitness
TERKER, ANDREW SVANDERBILT UNIVERSITY MEDICAL CENTERInnovative Therapeutic Approaches to Treat Chronic Kidney Disease
WILLIS, MARY DBOSTON UNIVERSITY MEDICAL CAMPUSA Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy
XIA, BOBROAD INSTITUTE, INC.Transposable Element Interaction and Its Impact on Human Development and Health
YANG, ANDREW CHRISUNIVERSITY OF CALIFORNIA, SAN FRANCISCOMolecular Tools to Decipher Communication Across the Blood-Brain Barrier

 

2021 NIH Director's Early Independence Award (DP5) - RFA-RM-20-014

*Diversity Statement

PI NameInstitution NameTitle
ABOUD, KATHERINEVANDERBILT UNIVERSITYBridging the Gap Between Brain Network Science and High-Definition Non-Invasive Brain Stimulation to Develop a Scalable Adult Literacy Intervention
AHMED, JALALICAHN SCHOOL OF MEDICINE AT MOUNT SINAIAdvancing CAR T Cell Therapy for Solid Tumors
BINTU, BOGDANUNIVERSITY OF CALIFORNIA, SAN DIEGOHigh-Throughput Imaging of 3D Chromatin Regulation Events in the Nervous System
CAPIN, JACOB JMARQUETTE UNIVERSITYLife After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
KOSS, BRIANUNIV OF ARKANSAS FOR MED SCISDiscovering T Cell Proteome Turnover Dynamics to Overcome the Solid Tumor Microenvironment
LEE, HONG HSIMASSACHUSETTS GENERAL HOSPITALRevealing Tissue Microstructure in the Brain Gray Matter in Alzheimers Disease Using In Vivo High-Gradient Diffusion MRI
MARSHALL, DEBORAH CATHERINEICAHN SCHOOL OF MEDICINE AT MOUNT SINAINovel Functional Anatomic and Biomarker Indices of Radiation-Induced Female Sexual Toxicities in a Multi-Center Cohort
NIGRA, ANNE ECOLUMBIA UNIVERSITY HEALTH SCIENCESPublic Drinking Water Contaminants and Infant Health: Advancing Environmental Justice
PITTER, KENNETH LOHIO STATE UNIVERSITYCellular Phenotypic Heterogeneity and Resistance to Radiotherapy in Pancreatic Adenocarcinoma
SHEYBANI, NATASHA DIBAUNIVERSITY OF VIRGINIAImmunoengineering Next-Generation Cancer Therapies with Focused Ultrasound
SHMUYLOVICH, LEONIDWASHINGTON UNIVERSITYInfrared Skin Imaging to Transform Noninvasive Diagnosis and Management of Skin Disease
SIMONETTI, FRANCESCO ROBERTOJOHNS HOPKINS UNIVERSITYInvestigating Antigen-Driven Clonal Proliferation to Target HIV-1 Persistence
WINETRAUB, YONATANSTANFORD UNIVERSITYOCT as a Platform for Non-Invasive Virtual H&E Biopsy

 

2020 NIH Director's Early Independence Award (DP5) - RFA-RM-19-008

*Diversity Statement

PI NameInstitution NameTitle
BAILEY, ADAM LEEUNIVERSITY OF UTAHDeterminants of Yellow Fever Pathogenesis in Humans
BAXTER, SALLY LIUUNIVERSITY OF CALIFORNIA, SAN DIEGOMulti-Modal Health Information Technology Innovations for Precision Management of Glaucoma
BICK, ALEXANDERVANDERBILT UNIVERSITY MEDICAL CENTERTargeting Clonal Hematopoiesis of Indeterminate Potential Using Human Genetics
CHO, HYUNGHOONBROAD INSTITUTE, INC.Computational Methods for Enhancing Privacy in Biomedical Data Sharing
EXPOSITO-ALONSO, MOISESCARNEGIE INSTITUTION OF WASHINGTON, D.C.Predicting and Controlling Polygenic Health Traits Using Probabilistic Models and Evolution-Inspired Gene Editing
GEORGE, JACOB ANTHONYUNIVERSITY OF UTAHPatient-Centered Rehabilitation and Dexterous Assistive Devices for Stroke Patients Using Bionic Exoskeletons Controlled by Non-Invasive Eectromyography
HILL, SARAH JAMESDANA-FARBER CANCER INSTDissecting the Interaction Between DNA Damage Repair Defects and the Tumor Microenvironment
HO, CHI-MINCOLUMBIA UNIVERSITY HEALTH SCIENCESMolecular Basis of Effector Protein Export in the Malaria Parasite Plasmodium falciparum
NAM, SEUNGWEILL MEDICAL COLL OF CORNELL UNIVDefining Malignant Hematopoiesis Via Single-Cell Multi-Omics
OPARA, IJEOMASTATE UNIVERSITY NEW YORK STONY BROOKUnderstanding the Role of Neighborhoods on Urban Youths Substance Use and Mental Health: A Community-Based Substance Abuse Prevention Project
STERGACHIS, ANDREWUNIVERSITY OF WASHINGTONInvestigating the Contribution of Non-Coding Genetic Variation to Rare Disorders
SUEZ, JOTHAMJOHNS HOPKINS UNIVERSITYThe Role of Non-Nutritive Sweeteners-Microbiome Interactions in the Pathogenesis of Metabolic Syndrome
TRIBLE, WARINGHARVARD UNIVERSITYThe Molecular Basis of Caste Development and Evolution in Ants

 

2019 NIH Director's Early Independence Award (DP5) - RFA-RM-18-010

*Advisory Committee to the NIH Director Working Group Findings

PI NameInstitution NameTitle
BRESTOFF, JONATHAN RWASHINGTON UNIVERSITYRegulation of Innate Immune Cell Responses Through Cell-to-Cell Transfer of Mitochondria
DEVRIES, ZACHARYNORTH CAROLINA STATE UNIVERSITY RALEIGHHistamine in Homes: Exposure Risks and Health Effects
EVRONY, GILAD DAVIDNEW YORK UNIVERSITY SCHOOL OF MEDICINESingle-Cell Genomic Approaches to Study the Cellular Origins of Brain Tumors
JONAS, STEVEN JOHNUNIVERSITY OF CALIFORNIA LOS ANGELESNanoscience-Inspired Acoustofluidic Assembly Lines for Gene and Cellular Therapies
KOSTOVA, KAMENACARNEGIE INSTITUTION OF WASHINGTON, D.C.How Cells Monitor the Integrity of Their Translation Apparatus
MINA, MICHAEL JHARVARD SCHOOL OF PUBLIC HEALTHDeconvolution and Reconstruction of Immune Histories to Enhance Infectious Disease Prevention and Vaccination Strategies and Optimize Surveillance Efforts
RAMACHANDRAN, KAPILHARVARD UNIVERSITYMolecular Determinants of Neuronal Protein Homeostasis Through Plasma Membrane-Localized Proteasome Complexes
SAMSTEIN, ROBERT MICAHN SCHOOL OF MEDICINE AT MOUNT SINAIDissecting the Influence of DNA Damage Response and Homologous Recombination Deficiencies on Tumor Immunogenicity
SCHLEIDER, JESSICA LEESTATE UNIVERSITY NEW YORK STONY BROOKHarnessing Network Science to Personalize Scalable Interventions for Adolescent Depression
SCHULMAN, SOLBETH ISRAEL DEACONESS MEDICAL CENTERFunctional Genetics of Tissue Factor in Bleeding and Thrombotic Risk
SHAFFER, SYDNEYUNIVERSITY OF PENNSYLVANIADecoding Mechanisms of Phenotypic Memory in Single Cells
ZHANG, HAICHONGWORCESTER POLYTECHNIC INSTITUTEMultiparametric Photoacoustic Imaging-Based Identification of Aggressive Prostate Cancer

 

2018 NIH Director's Early Independence Award (DP5) - RFA-RM-17-008

*Commitment to Diversity

PI NameInstitution NameTitle
BAKHOUM, SAMUEL FSLOAN-KETTERING INST CAN RESEARCHThe Role of Chromosomal Instability in Tumor Evolution
BILAL, USAMADREXEL UNIVERSITYThe Health Consequences of Urban Scaling
CHAO, HSIAO-TUANBAYLOR COLLEGE OF MEDICINEIlluminating GABAergic Signaling in Neurodevelopmental Disorders
DESELM, CARLWASHINGTON UNIVERSITYImmune Activating CAR-Modified Antigen Presenting Cells
ERB, MICHAEL ASCRIPPS RESEARCH INSTITUTETargeting Crotonyl-Lysine Chromatin Readers to Disrupt Pathogenic Gene Expression in Leukemia
GOULD, ALISONCALIFORNIA ACADEMY OF SCIENCESInvestigating Mechanisms of Specificity in a Bioluminescent Vertebrate-Bacteria Symbiosis
HEINSBROEK, JASPERMEDICAL UNIVERSITY OF SOUTH CAROLINADissecting Ventral Pallidal Subcircuit Contributions to Drug Seeking in Addiction
JAIN, ISHA HIMANIUNIVERSITY OF CALIFORNIA, SAN FRANCISCORedesigning a Neurons Breath: A Modern Twist to Classical Oxygen Biology
KNOUSE, KRISTIN AWHITEHEAD INSTITUTE FOR BIOMEDICAL RESDissecting and Engineering Reversible Cell Cycle States
OVCHINNIKOV, SERGEY LHARVARD UNIVERSITYExploring the Unknown Protein Universe Using Evolutionary Information
SELLMYER, MARK ANTHONYUNIVERSITY OF PENNSYLVANIANext Generation Tools for Imaging Bacterial Infection and Its Relationship to the Immune System
WEXLER, ANNAUNIVERSITY OF PENNSYLVANIADo-It-Yourself and Direct-to-Consumer Medicine and Science: Assessing the Public Health Issues and Regulatory Gaps

 

2017 NIH Director's Early Independence Award (DP5) - RFA-RM-16-006

*Statement on Diversity

PI NameInstitution NameTitle
ARBOLEDA, VALERIE ANNEUNIVERSITY OF CALIFORNIA LOS ANGELESUnraveling CorrelationsBetween Mendelian and Common Disease Using Functional Genomics
BADRAN, AHMED HUSSEINHARVARD UNIVERSITYFunctional Interrogation of Ribosomal Biology Using Continuous Evolution
CHEN, FEIBROAD INSTITUTE, INC.Characterizing Glioma Heterogeneity with Novel Multiplexed Nanoscale Imaging Technologies
EAGEN, KYLE PATRICKNORTHWESTERN UNIVERSITY AT CHICAGOBiochemical Basis of Chromatin Folding and Chromosome Condensation
FINUCANE, HILARYBROAD INSTITUTE, INC.Identifying Disease-Relevant Cell Types by Integrating Genetic and Functional Genomics Data
GYMREK, MELISSAUNIVERSITY OF CALIFORNIA SAN DIEGOSystematic Identification and Interpretation of Repetitive Variants Underlying Schizophrenia
LOH, KYLE MSTANFORD UNIVERSITYDeveloping Approaches for Universal Organ Transplantation
MEHR, SAMUEL AHARVARD UNIVERSITYPsychological Functions of Music in Infancy
MORRIS, ZACHARY SCOTTUNIVERSITY OF WISCONSIN-MADISONCombining Radiation and Tumor-Specific Antibody Therapies to Elicit In Situ Tumor Vaccination
SONG, ZIRUIHARVARD MEDICAL SCHOOLInequities in Health Outcomes in the Twenty-First Century: Understanding New Causes and the Impact of Delivery System Reforms on Health Care Disparities
ZHOU, CHUANKAIBUCK INSTITUTE FOR RESEARCH ON AGINGMechanism of Organelle Dysfunction During Aging and the Related Rejuvenation Process

 

2016 NIH Director's Early Independence Award (DP5) - RFA-RM-15-006

PI NameInstitution NameTitle
ABRAHAM, JONATHANBRIGHAM AND WOMEN'S HOSPITALAntibody Therapeutics for Human Viral Hemorrhagic Fevers and Prevention of Late Neurological Syndromes
BIND, MARIE-ABELE CATHERINEHARVARD UNIVERSITYTransporting Established Insights from Classical Experimental Design to Address Causal Questions in Environmental Epidemiology, Including the Understanding of Biological Mediating Mechanisms
BRUNKARD, JACOB OUNIVERSITY OF CALIFORNIA BERKELEYAn Aminoacyl tRNA Synthetase is a Nitrogen Sensor that Activates TOR in Plants
DEKOSKY, BRANDON JAMESUNIVERSITY OF KANSAS LAWRENCEComprehensive Analysis of Human Adaptive Immune Receptors to Elucidate Correlates of Epstein-Barr Virus Disease Suppression
DIVITO, SHERRIE JILLBRIGHAM AND WOMEN'S HOSPITALInvestigating a Novel Cell Population in Delayed-Onset Drug Hypersensitivity Reactions
DIXON, JESSESALK INSTITUTE FOR BIOLOGICAL STUDIESMechanisms of Formation of 3D Genome Structures
GANTZ, VALENTINO MATTEOUNIVERSITY OF CALIFORNIA SAN DIEGODevelopment, Characterization and Application of CRISPR/Cas9 Gene Drive Technologies and Related Active Genetic Elements to Benefit Research and Society at Large
GIOVENCO, DANIEL PHILIPRBHS-SCHOOL OF PUBLIC HEALTHGeographic Variation in the Diverse Tobacco Retail Environment and Its Impact on Tobacco Use Disparities
KOENIG, KRISTEN MARIEHARVARD UNIVERSITYInvestigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental Approaches
MANGLIK, AASHISHSTANFORD UNIVERSITYMolecular Mechanisms of Iron Homeostasis
MARTINEZ-BAKKER, MICAELA ELVIRAPRINCETON UNIVERSITYHacking Epidemics: Unlocking the Drivers of Transmission Seasonality to Battle Vaccome-Preventable Diseases
MUGNIER, MONICAJOHNS HOPKINS UNIVERSITYVariant Surface Glycoprotein Diversification in Trypanosoma brucei
RAMIREZ, STEVEHARVARD UNIVERSITYArtificially Modulating Memories to Alleviate Psychiatric Disease-Like States
RING, AARON MICHAELYALE UNIVERSITYUncoupling Pleiotropy in the LIGHT/HVEM/LTBetaR Signaling Network
SPITZER, MATTHEWUNIVERSITY OF CALIFORNIA, SAN FRANCISCOQuantitatively Modeling Immune Responses to Cancer
YACKLE, KEVINUNIVERSITY OF CALIFORNIA, SAN FRANCISCOCellular and Molecular Identification of the Breathing Pacemaker Neurons

 

2015 NIH Director's Early Independence Award (DP5) - RFA-RM-14-004

PI NameInstitution NameTitle
BONDY-DENOMY, JOSEPHUNIVERSITY OF CALIFORNIA, SAN FRANCISCODiscovering New Roles for CRISPR-Cas in Bacterial Pathogenesis 
BRAGG, MARIENEW YORK UNIVERSITY SCHOOL OF MEDICINEImpact of Racially Targeted Food and Beverage Ads on Adolescent Behavior
DEMEHRI, SHADMEHRWASHINGTON UNIVERSITYThe Mechanism of TSLP Anti-Tumor Effects in the Skin
GADE, TERENCE PUNIVERSITY OF PENNSYLVANIAImage-Based Phenotyping of Hepatocellular Carcinoma Cell Survival under Ischemic Stress: Toward Metabolic Imaging of Cancer Dormancy Using Hyperpolarized Carbon-13 Technology
GEE, DYLANYALE UNIVERSITYNovel Mechanisms of Fear Reduction Targeting the Biological State of the Developing Brain
GREENBLATT, MATTHEW BLAKEWEILL MEDICAL COLL OF CORNELL UNIVModulation of Bone Formation by SHN3
HILL, ELAINEUNIVERSITY OF ROCHESTERThe Health Consequences of Shale Gas Development
HSU, PATRICK DAVIDSALK INSTITUTE FOR BIOLOGICAL STUDIESEukaryotic Transcriptome Engineering via Sequence-Specific Regulation of Endogenous RNA
ISRAELSEN, WILLIAM JAMESUT SOUTHWESTERN MEDICAL CENTERDevelopment and Use of a Novel, Tractable Rodent Model for Studies of Hibernation Metabolism
KRUSE, ANDREWHARVARD COLLEGEMolecular Mechanisms of Adiponectin Signaling and PAQR Function
LYUMKIS, DMITRYSALK INSTITUTE FOR BIOLOGICAL STUDIESBreaking Barriers in Structural Biology: Novel CryoEM Methods and Applications
MEDAGLIA, JOHNUNIVERSITY OF PENNSYLVANIADynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control Dysfunction
SHELTZER, JASONCOLD SPRING HARBOR LABORATORYIdentification and Characterization of Genomic Features Affecting Survival Duration in Cancer
SOLOMON, DAVID AUNIVERSITY OF CALIFORNIA, SAN FRANCISCOCohesin Gene Mutations in Tumorigenesis
SONABEND, ADAM MCOLUMBIA UNIVERSITY HEALTH SCIENCESTOP2A Effects on Transcription in Gliomas: Implications for Personalized Therapy
ZHANG, ZHAOCARNEGIE INSTITUTION OF WASHINGTONSomatic Transposition-Mediated Genome Variegation during Development, Disease and Aging Conditions

 

2014 NIH Director's Early Independence Award (DP5) - RFA-RM-13-009

PI NameInstitution NameTitles
ALLISON, KYLE ROUSECOLUMBIA UNIVERSITY HEALTH SCIENCESIsolation and Systems-Level Characterization of Persistent Bacteria
ANGELO, ROBERT MICHAELSTANFORD UNIVERSITYPredictive Signatures in Breast Cancer Using Multiplexed Ion Beam Imaging
BERGELSON, ELIKADUKE UNIVERSITY Mechanisms of Word Learning in Infancy
CHAN, DAVID CHIMINPALO ALTO INSTITUTEThe Benefit and Burden of Electronic Reminders for Optimizing Patient Care
ESCOLA, GARY SEANCOLUMBIA UNIVERSITY HEALTH SCIENCESThe Internal States of Neural Circuits: Data Analysis, Modeling, and Disease
HANNA, JOHN WBRIGHAM AND WOMEN'S HOSPITALNew Ubiquitin-Proteasome System Components that Protect against Proteotoxicity
HILL, ALISON LYNNHARVARD UNIVERSITYQuantification and Prediction of Treatment Efficacy for HIV Cure Strategies
HYSTAD, PERRY WOREGON STATE UNIVERSITYPURE-AIR: A Global Assessment of Air Pollution and Cardiopulmonary Disease
JUDSON, ROBERT LAIRDUNIVERSITY OF CALIFORNIA SAN FRANCISCOMicroRNA-Based Detection of Barriers to Melanoma Progression
MARU, DUNCANBRIGHAM AND WOMEN'S HOSPITALIntegrating Pediatric Care Delivery in Rural Healthcare Systems
MEYER, AARON SAMUELMASSACHUSETTS INSTITUTE OF TECHNOLOGYAdapter-Layer RTK Signaling: Basic Understanding & Targeted DrugResistance
NELSON, ERIC JORGESTANFORD UNIVERSITYA Novel Approach to Improve Patient Care and Diarrheal Disease Research Using Mobile Technology
QUIROZ, YAKEEL TATIANAMASSACHUSETTS GENERAL HOSPITALMemory Network Dysfunction as an Early Marker of Preclinical Alzheimers Disease
RANDLES, AMANDA EUNIVERSITY OF CALIF-LAWRNC LVRMR NAT LABToward Coupled Multiphysics Models of Hemodynamics on Leadership Systems
SANTOS, GLENN-MILOPUBLIC HEALTH FOUNDATION ENTERPRISESThe Better THAN Study: Targeting Heavy Alcohol with Naltrexone among MSM
SIMON, NOAHUNIVERSITY OF WASHINGTONData-Driven Statistical Learning with Applications to Genomics
STOWELL, SEANEMORY UNIVERSITYExamination of Innate Immunity Against Molecular Mimicry

 

2013 NIH Director's Early Independence Award (DP5) - RFA-RM-12-018

PI NameInstitution NameTitles
ALUSHIN, GREGORY MROCKEFELLER UNIVERSITYMechanosensing via Cytoskeletal Strain
BACONGUIS, ISABELLE RHYSSA JOE EDURIAOREGON HEALTH AND SCI UNIVERSITYStructure and Function of Epithelial Sodium Channels
BJORNSSON, HANS TOMASJOHNS HOPKINS UNIVERSITYExploring Kabuki Syndrome as a Treatable Cause of Intellectual Disability
BRUENING, MEREDITH MARIZONA STATE UNIVERSITY-TEMPE CAMPUSThe Role of Friendship Networks on BMI and Behaviors among College Freshmen
CARTER, HANNAH KATHRYNUNIVERSITY OF CALIFORNIANetwork Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data
DENNY, CHRISTINE ANNCOLUMBIA UNIVERSITY HEALTH SCIENCESOptogenetic Dissection of Hippocampal Circuitry Underlying Alzheimers Disease
HSIAO, ELAINECALIFORNIA INSTITUTE OF TECHNOLOGYUncovering Microbial Modulators of Neuroactive Molecules as Novel Therapeutics
JENA, ANUPAM BAPUHARVARD UNIVERSITY (MEDICAL SCHOOL)Physician Determinants of Health Care Spending, Quality, and Patient Outcomes
LOURIDO, SEBASTIANWHITEHEAD INSTITUTE FOR BIOMEDICAL RESDissecting Essential Signaling Pathways in Apicomplexan Parasites
LOVELL, JONATHAN FSTATE UNIVERSITY OF NEW YORK AT BUFFALOTargeting Tumors with Resealable Nanovesicles Permeabilized by NIR Light
LUDINGTON, WILLIAMUNIVERSITY OF CALIFORNIA BERKELEYDeveloping a Reduced Complexity Model Gut Microbiome in the Behavior Model, Drosophila, and Bacteriophage Therapies to Modulate Behavior through the Microbiome
PINCUS, DAVIDWHITEHEAD INSTITUTE FOR BIOMEDICAL RESQuantitative Approaches to Reveal the Homeostatic Control Mechanisms of Stress Responses
QI, LEI STANLEYUNIVERSITY OF CALIFORNIA SAN FRANCISCOA Novel RNA-Guided Platform for Sequence-Specific Cell Reprogramming
WANG, ERIC TUNIVERSITY OF FLORIDAPost-Transcriptional Regulation of Gene Expression in Neuromuscular Disease
WEINBERG, DAVID ERICUNIVERSITY OF CALIFORNIA SAN FRANCISCOFormation and Regulation of the Translating mRNP

 

2012 NIH Director's Early Independence Award (DP5) - RFA-RM-11-007

PI NameInstitution NameTitles
ANTICEVIC, ALANYALE UNIVERSITYCharacterizing Cognitive Impairment in Schizophrenia via Computational Modeling and Pharmacological Neuroimaging
BATISH, MONAUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOLDetection of Chromosomal Translocations by Single Molecule RNA Imaging
CHEN, YVONNEUNIVERSITY OF CALIFORNIA LOS ANGELESEngineering of Computational Receptors and Gene Circuits for T-cell Immunotherapy
DE LA ZERDA, ADAMSTANFORD UNIVERSITYMolecular Imaging of Protein Glycosylation in Living Subjects
FORNWALT, BRANDON KUNIVERSITY OF KENTUCKYExploring the Role of Dyssynchrony in Pediatric Heart Disease with MRI
GUTTMAN, MITCHELLBROAD INSTITUTE, INC.Deciphering the Mechanism of Large ncRNA Mediated Regulation of Cell State
KAISER, WILLIAM JOSEPHEMORY UNIVERSITYRIP1 and RIP3 rRegulation of Apoptosis, Necrosis, and Inflammation
OBERMEYER, ZIADBRIGHAM AND WOMEN'S HOSPITALUnexpected Death after Medical Encounters: Measurement, Reporting, and Analysis
ROSENBERG, BRADROCKEFELLER UNIVERSITYImmune Profiling by High Throughput Sequencing of Complete Antigen Receptors
SONNENBERG, GREGORY FUNIVERSITY OF PENNSYLVANIARegulation of Host-Commensal Relationships in Human Health and Disease
THOMSON, MATTHEWUNIVERSITY OF CALIFORNIA SAN FRANCISCOQuantitative Models for Controlling Collective Cell Fate Selection in Stem Cells
VICTORA, GABRIEL DWHITEHEAD INSTITUTE FOR BIOMEDICAL RESIn Vivo Approaches to Dissecting B Cell-T Cell Cooperation in Germinal Centers
VILLEDA, SAUL AUNIVERSITY OF CALIFORNIA SAN FRANCISCORegulation of Neurogenesis and Cognition by Systemic Age-Related Immune Factors
YEH, ELLENSTANFORD UNIVERSITYDefining the Novel Eukaryotic Biology of the Apicomplexan Plastid

 

2011 NIH Director's Early Independence Award (DP5) - RFA-RM-10-019

PI NameInstitution NameTitles
BASTA, NICOLE ELAINEUNIVERSITY OF WASHINGTONAntibody Persistence after Conjugate Meningococcal Group A Vaccination in Mali
CALARCO, JOHN ANTHONYHARVARD UNIVERSITYInvestigating the Role of Alternative Splicing Regulatory Networks in Nervous System Development and Function
FRASER, JAMES SOLOMONUNIVERSITY OF CALIFORNIA SAN FRANCISCOThe Impact of Mutation on the Conformations and Recognition of Ubiquitin
HALFMANN, RANDAL ARTHURUNIVERSITY OF TEXAS SW MED CTR/DALLASContributions of Protein Aggregation to Gene Regulation and Phenotypic Diversity
KIDD, JEFFREY MSTANFORD UNIVERSITYCharacterizing the Global Architecture of Genomic Diversity
LEPPER, CHRISTOPHCARNEGIE INSTITUTION OF WASHINGTON, D.C.Molecular Mechanisms of Muscle Stem Cells Transitioning Intoquiescence
OLSEN, CARISSAFRED HUTCHINSON CANCER RESEARCH CENTERDefining the Impact of Lipid Synthesis and Turnover on Aging in C. elegans
SAMACO, RODNEY CBAYLOR COLLEGE OF MEDICINEThe Genetic and Neuroanatomical Origin of Social Behavior
WANG, HARRIS HHARVARD UNIVERSITY (MEDICAL SCHOOL)Functional Metagenomic Reprogramming of the Human Microbiome through Mobilome Engineering
WITTEN, DANIELAUNIVERSITY OF WASHINGTONHigh-Dimensional Unsupervised Learning, with Applications to Genomics
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