Many biological experiments are performed on groups of cells, under the assumption that all cells of a particular “type” are identical. However, recent evidence from studies of single cells reveals that this assumption is incorrect. Individual cells within the same population may differ dramatically, and these differences can have important consequences for the health and function of the entire population.
Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing
The unavailability of 3D structural maps for many organs makes understanding the structure-function relationships at cellular, circuit and organ-wide scale difficult. This knowledge gap has been attributed to the absence of a method that enables whole-organ imaging. In this publication, several techniques are described that allow for the process of tissue clearing during which whole organs and bodies are rendered optically transparent, thereby exposing their cellular structure with intact connectivity.
Save the Date! 2015 Annual PI Meeting Information
The 3rd Annual Single Cell Analysis Investigators Meeting is scheduled for April 20-21, 2015, in the Bethesda area, Maryland. Please save the date! More details will be available at the end of this year.
Funding Opportunity Announcement for Single Cell Analysis Program
The Development of Highly Innovative Tools and Technology for Analysis of Single Cells FOA is affiliated with the Common Fund Single Cell Analysis Program (SCAP), but is not receiving direct Common Fund support. Awards made through this FOA will be funded by participating component NIH Institutes and Centers.