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Program Snapshot

Many biological experiments are performed on groups of cells, under the assumption that all cells of a particular “type” are identical. However, recent evidence from studies of single cells reveals that this assumption is incorrect. Individual cells within the same population may differ dramatically, and these differences can have important consequences for the health and function of the entire population.

Program Highlights

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

The unavailability of 3D structural maps for many organs makes understanding the structure-function relationships at cellular, circuit and organ-wide scale difficult. This knowledge gap has been attributed to the absence of a method that enables whole-organ imaging. In this publication, several techniques are described that allow for the process of tissue clearing during which whole organs and bodies are rendered optically transparent, thereby exposing their cellular structure with intact connectivity.

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Save the Date! 2015 Annual PI Meeting Information

The 3rd Annual Single Cell Analysis Investigators Meeting is scheduled for April 20-21, 2015, in the Bethesda area, Maryland.  Please save the date!  More details will be available at the end of this year.


NEW! Register for the “Follow that Cell” Challenge

Single Cell Analysis Collage

The NIH is seeking novel robust methods for analysis of individual cells that  can detect and assess changes in cell behavior and function over time either as a result of natural state changes or when perturbed. Read More

Register and submit your solution for the challenge here
See the Federal Register Notice 
Submission Deadline (Phase 1): December 15, 2014
Phase 1 Winners and other Finalists Announced: March 16, 2015

Related links
"Follow that Cell" Challenge Press Release 
Seeker Spotlight 
"Follow that Cell" YouTube Video featuring Dr. Insel 





Funding Opportunity Announcement for Single Cell Analysis Program

Development of Highly Innovative Tools and Technology for Analysis of Single Cells

The Development of Highly Innovative Tools and Technology for Analysis of Single Cells FOA is affiliated with the Common Fund Single Cell Analysis Program (SCAP), but is not receiving direct Common Fund support. Awards made through this FOA will be funded by participating component NIH Institutes and Centers.









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