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Program Snapshot

The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:

  • Large-scale production of perturbation-induced molecular and cellular signatures
  • Creation of a database, common data standards and public user interface for accessing the data
  • Computational tool development and integrative data analyses
  • Development of new cost-effective, molecular and cellular phenotypic assays
  • Integration of existing datasets into LINCS

Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.

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Program Highlights

LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce 

Cancer, generally speaking, occurs due to unregulated cell reproduction. As cells grow and multiply unchecked they need to produce more proteins, ultimately leading to the formation of tumors.

Program Highlights

LINCS Researchers Find New Insights into Measures of Drug ActivityLINCS Researchers Find New Insights into Measures of Drug Activity

More effective therapeutics are needed for numerous conditions affecting people, yet drug development remains inefficient.


NEW! BD2K-LINCS Perturbation Data Coordination and Integration Center (DCIC) Grant Awarded. The Icahn School of Medicine at Mount Sinai was chosen as the new DCIC to coordinate efforts between the LINCS and BD2K initiatives. Read the BD2K awards press release. Visit the BD2K Funded Research page to learn more about the grant.

Grants for Second Phase of LINCS Program Awarded. After a successful 3-year pilot project, the NIH announces $64 million in awards to establish 6 LINCS Data and Signature Generating Centers. Read the press release.

NIH LINCS Program​​
View materials from the LINCS Data Forum 2013

LINCS hosted a two-day workshop on March 20-21, 2013 which included presentations, discussions, and tutorials on LINCS science, data resources, and software tools. Presentations and videos from this are available here. Exit Disclaimer


ACCESS THE LINCS PORTAL The LINCS portal is a source of information for the research community and general public about the LINCS project.  The portal contains details about the assays, cell types, and perturbagens currently part of the library, as well as links to participating sites, the data releases from the sites, and software that can be used for analyzing the data. Click on the image below to get started. Exit Disclaimer


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