The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a library of molecular signatures that describes how different types of cells respond to a variety of agents that disrupt normal cellular functions, called “perturbagens.” This library may help us better understand normal and diseased cellular states and how to alter them.
The program currently supports LINCS Data and Signature Generation Centers and coordinates with the NIH Big Data to Knowledge (BD2K) initiative through a BD2K-LINCS Data Integration and Coordination Center.
Sex and gender play a role in how health and disease differ across individuals, and considering these factors during research informs the development of preventive and therapeutic interventions for both sexes. Learn how supplements to LINCS grants are enabling researchers to investigate sex as a biological variable.
Cancer, generally speaking, occurs due to unregulated cell reproduction. As cells grow and multiply unchecked they need to produce more proteins, ultimately leading to the formation of tumors.