The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:
- Large-scale production of perturbation-induced molecular and cellular signatures
- Creation of a database, common data standards and public user interface for accessing the data
- Computational tool development and integrative data analyses
- Development of new cost-effective, molecular and cellular phenotypic assays
- Integration of existing datasets into LINCS
Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.
LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce
Cancer, generally speaking, occurs due to unregulated cell reproduction. As cells grow and multiply unchecked they need to produce more proteins, ultimately leading to the formation of tumors.
LINCS Researchers Find New Insights into Measures of Drug Activity
More effective therapeutics are needed for numerous conditions affecting people, yet drug development remains inefficient.
LINCS hosted a two-day workshop on March 20-21, 2013 which included presentations, discussions, and tutorials on LINCS science, data resources, and software tools. Presentations and videos from this are available here.