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Library of Integrated Network-Based Cellular Signatures (LINCS): Perturbation-Induced Data and Signature Generation Centers (U54) RFA-RM-13-013
PI Name Institution Name Title
GOLUB, TODD R. (contact)
SUBRAMANIAN, ARAVIND
BROAD INSTITUTE, INC. Broad Institute LINCS Center for Transcriptomics
GRAY, JOE W. (contact)
HEISER, LAURA
KORKOLA, JAMES
OREGON HEALTH & SCIENCE UNIVERSITY Extrinsic Perturbations of Cell Physiology and Associated Regulatory Networks
IYENGAR, SRINIVAS RAVI V (contact)
BIRTWISTLE, MARC R
SOBIE, ERIC A
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Drug Combination Signatures for Prediction and Mitigation of Toxicity
JAFFE, JACOB DAVID BROAD INSTITUTE, INC. There and Back Again: Epigenetic Reinforcement of Cellular Signaling States - Overall
SORGER, PETER KARL HARVARD UNIVERSITY (MEDICAL SCHOOL) Pharmaco Response Signatures and Disease Mechanism
THOMPSON, LESLIE MICHELS (contact)
FINKBEINER, STEVEN M
FRAENKEL, ERNEST
ROTHSTEIN, JEFFREY D
SVENDSEN, CLIVE NIELS
UNIVERSITY OF CALIFORNIA-IRVINE Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells

 

Large Scale Production of Perturbagen-Induced Cellular Signatures (U54) RFA-RM-10-003

PI Name Institution Name Title
GOLUB, TODD R. (contact) WINCKLER, WENDY BROAD INSTITUTE, INC. Large scale gene expression analysis of cellular states
MITCHISON, TIMOTHY J.(contact) SORGER, PETER KARL HARVARD UNIVERSITY (MEDICAL SCHOOL) Pharmaco Response Signatures and Disease Mechanism

 

Advanced Technologies for Detection of Perturbation-Induced Cellular Signatures (U01) RFA-RM-10-004
PI Name Institution Name Title
CALIFANO, ANDREA COLUMBIA UNIVERSITY HEALTH SCIENCES Profiling Signatures of synergistic Chemical Perturbations in Diverse Cellular C
JAFFE, JACOB DAVID (contact) MACCOSS, MICHAEL J BROAD INSTITUTE, INC. Accelerated Protein Signaling Signatures
MELDRUM, DEIRDRE R. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Live-cell Microarray for high-throughput observation of metabolic signatures
MILLER-JENSEN, KATHRYN (contact) FAN, RONG YALE UNIVERSITY Detection of Protein Signal Transduction Signatures in Single Cells

 

Computational Tool Development and Integrative Data Analysis for LINCS (U01) RFA-RM-10-005
PI Name Institution Name Title
CALIFANO, ANDREA COLUMBIA UNIVERSITY HEALTH SCIENCES A Systems Approach to Elucidate Mechanisms of Drug Activity and Sensivity
MEDVEDOVIC, MARIO UNIVERSITY OF CINCINNATI Integrative statistical methods and tools for analysis of perturbation signatures
SCHURER, STEPHAN C UNIVERSITY OF MIAMI SCHOOL OF MEDICINE LINCS Information FramEwork (LIFE) to Integrate and Analyze Diverse Data Set
ZHOU, XIAOBO (contact) CHANG, CHUNG-CHE METHODIST HOSPITAL RESEARCH INSTITUTE itNETZ: Integrative and Translational Network-based Cellular Signature Analyzer
 
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