4D Nucleome (logo)

Program Snapshot

The Common Fund’s 4D Nucleome program aims to understand the principles behind the three-dimensional organization of the nucleus in space and time (the 4th dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.

The 4D Nucleome program issued its awards in September of 2015. During the first two years, 4DN awardees organized themselves into a 4DN Network poised to achieve the overall goals of the program. This included the establishment of data standards, a set of common cell lines, a publication policy, a data portal, community outreach, and joint analysis projects to benchmark various imaging and multi-omics 4DN tools and approaches. The organization of the 4DN program is described in a 2017 marker paper in Nature. The program also made ten Transformative Collaborative Project Awards (TCPAs) in 2017, eight of which were funded by NIH. Program deliverables currently available through the public 4DN Portal include nearly 2000 datasets from hundreds of experiments, 52 software packages and 23 protocols. 4DN officially joined the International Human Epigenome Consortium (IHEC) in October of 2017.



This page last reviewed on April 12, 2019