The Protein Capture Reagents Program data portal goes live. Researchers can find information on publicly-available affinity reagents for human transcription factors including: antigen source, binder type, performed validations and links to distributors.
Protein Capture Reagents Data Portal
International Collaboration on Protein Affinity Reagents
The Protein Capture Reagents Program, part of the NIH Office of the Director, signed a Memorandum of Understanding (MOU) with the Affinomics consortium and the Human Protein Atlas . The purpose of the MOU is to set up cooperative activities in the production and use of protein affinity reagents. The NIH and these European programs have unique missions but many common goals. The cooperation guided by this MOU should benefit all programs and the main goal of generating valuable resources for protein affinity reagents for the scientific community.
Combining Techniques to Create Optimal Affinity Reagents
Protein Capture Reagents Program grantee Dr. H. Tom Soh and colleagues have combined multiple high-throughput methods to efficiently create and validate affinity reagents called apatmers. The aptamers developed in this study recognize a specific protein commonly found on the surface of stem cells. Reagents like these may one day help researchers isolate stem cells from a complex mixture of cells. Read: “Development of an Efficient Targeted Cell-SELEX Procedure for DNA Aptamer Reagents” .
“Calling the Next Generation of Affinity Reagents”
Nature Methods reports on efforts by the NIH Common Fund Protein Capture Reagents Program and scientists around the world to fill the need for renewable and reliable affinity reagents that can detect and isolate specific protein molecules. Scientists are refining and validating older technologies or designing all new ones to provide biomedical researchers with high-quality affinity reagents. Find out how high-throughput methods are being combined with technologies ranging from traditional antibody proteins to engineered nucleic acid/protein hybrids to address this important hurdle for biomedical discovery. Read the article
Schematic of Protein Capture Reagents program components