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Program Snapshot

The High-Risk, High-Reward Research program has four unique funding opportunities for exceptionally creative scientists who propose highly innovative approaches to major challenges in biomedical research:

           

 

           

In the News

Developing an Auto-Focusing Contact Lens Modeled after Fish

Hongrui Jiang, a 2011 New Innovator, designed extremely small, super light-sensitive sensors inspired by the retina of elephant nose fish. The work is a step towards creating a contact lens that autofocuses within milliseconds that can be used to treat presbyopia. Jiang's work is featured in an NIH press release and on Discovery News.  Read more


PBS's NOVA Features Christine Denny in "Memory Hackers"

Christine Denny, a 2013 Early Independence awardee, was featured in PBS's NOVA "Memory Hackers,"  which aired February 10, 2016 on PBS. The special examines the science of memory editing.

Program Booklet  •  Abstract Book  •  Photos  •  Videocasts for Day 1Day 2, and Day 3

Application Information

Comparison of  High Risk-High Reward Programs

APPLICATION STATUS
  Pioneer Award New Innovator
Award
Transformative
Research Award

Early Independence
Award

FY 2018

Announcement: Spring
Due Date: Fall

Announcement: Spring
Due Date: Fall

Announcement: Spring
Due Date: Fall

Announcement: Spring
Due Date: Fall

FY 2017

RFA-RM-16-005
Under Review

RFA-RM-16-004
Under Review

RFA-RM-16-007
Under Review

RFA-RM-16-006
Under Review

Announcements

The 2018 High-Risk, High-Reward Research Symposium is Coming June 2018


2017 PECASEWhite House Press ReleaseGregory AlushinManish AroraChristine HendonMichael McAlpine

Congratulations to the 2017 PECASE recipients for their High-Risk, High-Reward Research projects! High-Risk High-Reward Research awardees who received PECASE awards for research projects supported by other agencies include Aaron Esser-Kahn (New Innovator), Ahmad Khalil (New Innovator), Elizabeth Nolan (New Innovator) and Harris Wang (Early Independence awardee).

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