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Science of Behavior Change

Frequently Asked Questions for Science of Behavior Change FOAs

1. What is the Common Fund?

2. What is the Science of Behavior Change Program?




3. What is the experimental approach?

4. What scientific expertise is required for the experimental medicine approach to behavior change?

5. What are putative intervention targets?

6. Why do these announcements have a specific focus on adherence to medical regimens?

7. What is meant by medical regimen adherence?

8. Who are appropriate subjects, and what is an appropriate setting, for this research? Does the work on medical regimen adherence need to be conducted in individuals for whom specific medical regimens have been prescribed or recommended?

9. What are cooperative agreements?

10. What is the SOBC Research Network Steering Committee?

11. How are Program Officers assigned for Common Fund programs?

12. Can applications from the same institution be submitted for a UH2/UH3 project and the U24 Resource and Coordinating Center?

13. Can an institution/research team submit more than one application to a one RFA or submit an application to more than one of these companion RFAs (i.e., one interpersonal and social processes project and one self-regulation project)?

FAQs Specific to the UH2/UH3 RFAs (RFA-RM-14-018RFA-RM-14-019RFA-RM-14-020)

14. The UH2/UH3 RFAs mention the need to focus on targets relevant to two (or more) health behaviors relevant to two (or more) clinical endpoints or conditions. How are these targets, behaviors and endpoints supposed to be related?

15. Can a project be funded as a UH2 for the 5-year award period?

16. Does adherence to medical regimens have to be included in my application?

17. What type of expertise is necessary for the UH2/UH3 investigator team?

18. Are studies of preclinical nonhuman primates responsive to these RFAs?

19. Can these projects support the conduct of a large scale clinical trial?

20. If clinical trials are not permitted, is this announcement just calling for basic science?

21. What sorts of experimental manipulation or intervention techniques are permitted for testing target engagement?

22. Can research teams span institutions?

23. Can an institution or research team submit more than one application to a given RFA (or submit one interpersonal processes project and one stress project)?

24. How will the transition from UH2 to UH3 be determined?

FAQs Specific to the U01 Resource and Coordinating Center (RCC) RFA (RFA-RM-14-017)

25. What is the role of the Resource and Coordinating Center (RCC) and how will it relate to the UH2/UH3 projects?

26. What type of expertise is necessary for the RCC investigator team?

Questions generated from the January 21, 2015 Webinar

27. Is integrated data analysis on existing data permissible for the UH2 phase?

28. Is the new biosketch format required?

29. What types of samples or populations are considered appropriate for UH2 phase (e.g., clinical, disease-specific, org general population)?

30. What constitutes medical regimen adherence? Would exercise count?

31. For the UH2, will we have to test the link between medical regimen adherence and, for example, self-regulation?

32. Is the funding cap for the UH3 phase of the project $1.25 million per year, or for the total UH3 phase?

33. Are senior investigators likely to be more successful give the collaborative nature of these projects? Is it expected that senior investigators will be the ones applying?

34. Can applications involve qualitative data collection as part of measuring putative targets? [Relevant to FAQ #27]

35. Does the Resources and Coordinating Center have a separate RFA or does each application need a coordinating center?

36. Do interventions need to be on an individual level or a community level?

37. Would it be better to have multiple PD/PI as well as multi-institutions apply?

38. How should applicants budget for the UH3 phase if the results of the UH2 phase are unknown? For example, how would specific budget lines be determine?

39. How many awards are expected to be made for each RFA?

40. Would probing the targets using pharmacological probes be acceptable?

41. For the budget caps, are the indirect cost associated with the subcontract sites part of the total cost, or are they separate from (in addition to) the total cost?

42. Please clarify what is meant by basic in the RFA where it notes that "both basic and clinical scientist" are required for the UH2/UH3 teams? Does basic here mean testing human blood and/or tissues, research in animals, or something else?

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