Science of Behavior Change
Frequently Asked Questions for Science of Behavior Change FOAs
We appreciate your interest in the Science of Behavior Change funding opportunities and hope that you and your team will choose to submit an application. In order to maximize your chances of success, we would like to provide some guidance that may be helpful as you put the finishing touches on your application:
1. Your application should clearly state the targets (mechanisms or processes) on which it will focus, and the health behaviors that changes in those target processes are hypothesized to cause. Stated another way, your application should describe hypothesized causal chains, starting from your chosen manipulations of a target to resulting changes in health behaviors. We say “describe causal chains” because it is likely that there will be separate causal chains for each chosen target-health behavior relationship.
2. In response to the Letters of Intent received and other questions from potential applicants, we have developed additional FAQs which have been added below. Topics that seem to be particularly confusing are what constitutes medical regimen adherence and how to make the case for the relevance to clinical outcomes or conditions in the application. Please review these FAQs to be sure that your application is consistent with the information provided here.
3. For clarification of these or other issues, we encourage you to talk with one or more of the scientific contacts listed in the RFA to which you are applying.
8. Who are appropriate subjects, and what is an appropriate setting, for this research? Does the work on medical regimen adherence need to be conducted in individuals for whom specific medical regimens have been prescribed or recommended?
13. Can an institution/research team submit more than one application to a one RFA or submit an application to more than one of these companion RFAs (i.e., one interpersonal and social processes project and one self-regulation project)?
14. The UH2/UH3 RFAs mention the need to focus on targets relevant to two (or more) health behaviors relevant to two (or more) clinical endpoints or conditions. How are these targets, behaviors and endpoints supposed to be related?
FAQs Specific to the U01 Resource and Coordinating Center (RCC) RFA (RFA-RM-14-017)
- Conducting systematic reviews and meta-analyses of existing clinical trial reports and archived data sets, and using these sources to generate testable hypotheses concerning potential putative intervention targets, differential response of individuals to treatment, and estimates of intervention efficacy and effectiveness.
- All aspects of behavior change research and NIH-approved Good Clinical Practices (see http://www.nhlbi.nih.gov/research/funding/research-support/crg/managemen... for more information) as well as ethical issues related to clinical research.
- Facilitating cooperation between basic and clinical scientists and in behavioral intervention development.
- Helping to take research questions from hypothesis to implementation and the ability to document these processes.
- Study design and statistics, particularly with novel designs and methods that could enhance the efficiency of validation studies and behavioral trial designs.
- Creativity and innovation in solving technical and project challenges, as well as coordinating efforts among disparate research communities.
- The three target domains (self-regulation; stress reactivity and stress resilience; interpersonal and social processes) sufficient to participate as a member of the subcommittee for that target domain and ensure that products produced by target domain subcommittees will be suitable for the first three objectives of the RCC.
Questions generated from the January 21, 2015 Webinar
42. Please clarify what is meant by basic in the RFA where it notes that "both basic and clinical scientist" are required for the UH2/UH3 teams? Does basic here mean testing human blood and/or tissues, research in animals, or something else?
Applications that do not have a component related to medical regimen adherence will be deemed non-responsive.
• A clear plan of operation for the administrative structure and proposed interactions among the investigators
• A clear description of the collaborative team process that will be used for the work proposed
• A clear plan for lines of communication and exchange of data among team members
• A rationale explaining how integration and collaboration among participants will be fostered
• A clear articulation of the role(s) and responsibilities for each member of the team and how this will provide the requisite synergies for the research activities in the UH2/UH3
• The Team Science Justification and Organization attachment is not in lieu of the additional requirements if the institution is submitting a multiple PI application.
• Applications lacking the Team Science Justification and Organization attachment will be deemed incomplete and will not be reviewed.
If you have already submitted your application without a Team Science Justification and Organization attachment, you can amend your application up to the March 20, 2015 receipt date.
FAQs Specific to the Science of Behavior Change Administrative Supplements (PA-16-344)
53. Do we need to show not only that the treatment moves target, but also whether engaging the target impacts clinical endpoints? Also, will we need to measure the putative mechanism at more than one time point? Is that feasible in the time frame and budget?
This page last reviewed on May 12, 2017