Part of the Common Fund's High-Risk, High-Reward Research program, the NIH Director's Transformative Research Award supports exceptionally innovative, unconventional, paradigm-shifting research projects that are inherently risky and untested.
Peng Yin, a 2010 New Innovator and 2013 Transformative Research awardee, enhanced DNA nanotechnology-powered super-resolution microscopy to visualize distinct molecules five nanometers apart. The method opens the way for researchers to study individual molecular features in molecular complexes.
Treating Mitochondrial Disease with Hypoxia
Vamsi Mootha (2011 Transformative Researcher) and Feng Zhang (2010 and 2015 Transformative Researcher and 2012 Pioneer) found low levels of oxygen is an effective therapy for mitochondrial diseases, which are debilitating and largely untreatable. Zebrafish and mouse models showed fewer symptoms and had a dramatically longer life span when raised in a low oxygen environment.
The Office of the Director in partnership with
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Cancer Institute
- National Center for Complementary and Integrative Health
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging