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Program Snapshot

Part of the Common Fund's High-Risk, High-Reward Research program, the Transformative Research Award supports exceptionally innovative, unconventional, paradigm-shifting research projects that are inherently risky and untested.

 

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Highlights

Ultra-Resolution Microscopy

MoleculesPeng Yin, a 2010 New Innovator and 2013 Transformative Research awardee, enhanced DNA nanotechnology-powered super-resolution microscopy to visualize distinct molecules five nanometers apart. The method opens the way for researchers to study individual molecular features in molecular complexes.

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Treating Mitochondrial Disease with Hypoxia

Respiratory Care deviceVamsi Mootha (2011 Transformative Researcher) and Feng Zhang (2010 and 2015 Transformative Researcher and 2012 Pioneer) found low levels of oxygen is an effective therapy for mitochondrial diseases, which are debilitating and largely untreatable. Zebrafish and mouse models showed fewer symptoms and had a dramatically longer life span when raised in a low oxygen environment.

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Manipulating the Electron Transport Chain

Reflective cells with illuminationVamsi Mootha, a 2011 Transformative Researcher, created a nicotinamide adenine dinucleotide (NAD+) producing bacteria Lactobacillus brevis (LbNOX) for manipulating the crucial electron transport system in mitochondria. Increasing NAD+ in the cytosol or mitochondria improved proliferative and metabolic defects caused by an impaired electron transport chain.
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Transformative_Awards@mail.nih.gov

In partnership with NICHD, FIC, NCI, NCCIH, NEI, NHLBI, NHGRI, NIAD, NIAMS, NIBIB, NIDDK, NIEHS, NIGMS, NIMH, NINR, NIA, NIDA, NINDS, NLM, and NIH

Application Information

Hand filling out a form•  Open to individuals or teams at all career stages
•  No limits on budget requests
•  Find IC-specific guidelines for Clinical Research
•  Find an IC contact for Scientific Research
•  More information
 

Application Status
FY 2017

RFA-RM-16-007
Closed

High Risk, High Reward FAQ

Announcements

Congratulations to the 2016 NIH Director's Transformative Research Awardees! (pictured)
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High Risk, High Reward Research Symposium
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Julie Dunning HotoppJulie Dunning Hotopp Featured in NIH Director's Blog

Julie Dunning Hotopp, a 2015 Transformative Researcher, is featured in the NIH Director's Blog discussing her work on bacterial gene transfer into the human genome and its impact on human cancers. While there is evidence that cancerous cells harbor more bacterial genes, it isn't clear if the bacterial genes cause the cancer or if cancer is more prone to taking in the genes, a relationship Dunning Hotopp intends to elucidate.


Dianne NewmanDianne Newman Gives NIH Director's Wednesday Afternoon Lecture

Dianne Newman spoke at the January 13, 2016, NIH Director's Wednesday Afternoon Lecture on “The Importance of Growing Slowly: Roles for Redox Active “Antibiotics” in Microbial Survial.” Watch the Videocast.


Gold TrophyEdward Boyden and Karl Deisseroth Receive 2016 Life Sciences Breakthrough Prize


Edward Boyden (2007 New Innovator, 2012 and 2013 Transformative Research, and 2013 Pioneer awardee) and Karl Deisseroth (2005 Pioneer and 2012 Transformative Research awardee) were awarded $3 million each for the 2016 Breakthrough Prize in Life Sciences

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