The Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) provides broad, standardized phenotyping of a genome-wide collection of mouse knockouts generated by the International Knockout Mouse Consortium (IKMC), funded by the NIH, European Union, Wellcome Trust, Canada, and the Texas Enterprise Fund.
Researchers Use KOMP2 Mice to Learn About Genes That Help Repair Heart Tissue
The mammalian heart has the capacity to “self-renew,” or repair itself, but only early in life. Understanding more about the genes and mechanisms involved in heart repair during early life may provide clues into possible therapeutic approaches to reactivating this capacity in the adult heart.
Illuminating Essential Gene Function in Mice
Drs. Mary Dickinson and Steve Murray and collaborators, as part of the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC), have been using mouse models to study essential genes.
IMPC Leads Coordinated Effort to Characterize Every Gene in the Mouse Genome
A recent Biocentury Innovations report features the progress made by the International Mouse Phenotyping Consortium (IMPC), which is an international mouse phenotyping partnership between ten countries and includes the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2).
New Statistical Tools for Standardizing High Throughput Analysis in Mouse Phenotyping
Researchers funded by the National Institutes of Health’s Common Fund Knockout Mouse Phenotyping Program (KOMP2) are are developing statistical tools to help researchers analyze large amounts of phenotyping data.
NIH-Funded KOMP2 Program Leads the Way in Efforts to Ensure Reproducibility and Enhance Transparency in Research
Researchers funded by the National Institutes of Health’s Common Fund Knockout Mouse Phenotyping Program (KOMP2) are making efforts to improve methods of data collection and reporting in animal research, with the goals of making these processes more accessible and research findings more reproducible.
A Comprehensive New Atlas for Knockout Mice Phenotypes
Research supported by the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) have developed a comprehensive atlas detailing gene expression patterns in different mutant mouse lines.
Applying a New Method to Generate Knockout Mice
Research supported by the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) has applied a new way to generate conditional knockout mice, which are mice with a gene that can be selectively eliminated in specific cells or tissues at a specific point in time.
Looking for information about mice phenotyped through KOMP2? Visit www.mousephenotype.org, where you can use the "Search" function to search by gene, phenotype, anatomy, or protocol.
The International Mouse Phenotyping Consortium (IMPC) has released a new video describing efforts and resources from the Consortium!
International Efforts in Mouse Phenotyping
KOMP2 is partnering with organizations from ten countries as part of the International Mouse Phenotyping Consortium (IMPC) in an internationally coordinated effort to undertake a broad-based, systematic genome-wide phenotyping of knockout mice.
Visit the IMPC website here
Read more about the IMPC Informatics Team here