The Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) provides broad, standardized phenotyping of a genome-wide collection of mouse knockouts generated by the International Knockout Mouse Consortium (IKMC), funded by the NIH, European Union, Wellcome Trust, Canada, and the Texas Enterprise Fund.
IMPC Leads Coordinated Effort to Characterize Every Gene in the Mouse Genome
A recent Biocentury Innovations report features the progress made by the International Mouse Phenotyping Consortium (IMPC), which is an international mouse phenotyping partnership between ten countries and includes the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2).
New Statistical Tools for Standardizing High Throughput Analysis in Mouse Phenotyping
Researchers funded by the National Institutes of Health’s Common Fund Knockout Mouse Phenotyping Program (KOMP2) are are developing statistical tools to help researchers analyze large amounts of phenotyping data.
NIH-Funded KOMP2 Program Leads the Way in Efforts to Ensure Reproducibility and Enhance Transparency in Research
Researchers funded by the National Institutes of Health’s Common Fund Knockout Mouse Phenotyping Program (KOMP2) are making efforts to improve methods of data collection and reporting in animal research, with the goals of making these processes more accessible and research findings more reproducible.
A Comprehensive New Atlas for Knockout Mice Phenotypes
Research supported by the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) have developed a comprehensive atlas detailing gene expression patterns in different mutant mouse lines.
Applying a New Method to Generate Knockout Mice
Research supported by the Common Fund’s Knockout Mouse Phenotyping Program (KOMP2) has applied a new way to generate conditional knockout mice, which are mice with a gene that can be selectively eliminated in specific cells or tissues at a specific point in time.
Looking for information about mice phenotyped through KOMP2? Visit www.mousephenotype.org, where you can use the "Search" function to search by gene, phenotype, anatomy, or protocol.
FEATURE OF THE MONTH
The International Mouse Phenotyping Consortium (IMPC) is looking to make improvements in its data accessibility and needs your input!
Consider taking time to participate in a survey that aims to make IMPC data easily accessible to everyone looking for phenotypes, images and raw data. Please find the survey here
Visit the IMPC site at mousephenotype.org, and be sure to check back often as new data is added and accessibility is improved!
KOMP2 investigators publish important resources, advances, and challenges for mouse phenotyping
- Overview of the International Mouse Phenotyping Consortium (IMPC)
- Overview of the International Knockout Mouse Consortium (IKMC)
- Information on the KOMP Repository
- Informatics infrastructure developments in mouse phenotyping
- Resources for conditional mutagenesis studies
- Unifying ontology for phenotypic data
Images showing KOMP2 research (clockwise from top): a genetically modified chimeric mouse; a researcher preparing tissue samples for analysis; a mouse embryo showing expression (in blue) of one member of the TCF/LEF family of genes, a regulator of several important biological pathways.
International Efforts in Mouse Phenotyping
KOMP2 is partnering with organizations from ten countries as part of the International Mouse Phenotyping Consortium (IMPC) in an internationally coordinated effort to undertake a broad-based, systematic genome-wide phenotyping of knockout mice.
Visit the IMPC website here
Read more about the IMPC Informatics Team here