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Program Snapshot

The Common Fund's Genotype-Tissue Expression (GTEx) program aims to study human gene expression and regulation in multiple tissues, providing valuable insights into the mechanisms of gene regulation and, in the future, its disease-related perturbations. Genetic variation between individuals will be examined for correlation with differences in gene expression level to identify regions of the genome that influence whether and how much a gene is expressed. The GTEx project includes the following initiatives:

  • Novel Statistical Methods for Human Gene Expression Quantitative Trait Loci (eQTL) Analysis
  • Laboratory, Data Analysis, and Coordinating Center (LDACC)
  • caHUB Acquisition of Normal Tissues in Support of the GTEx Project


Program Highlights

The Genotype-Tissue Expression (GTEX) project Commentary is featured in Nature Genetics

The June 2013 issue of Nature Genetics highlights the GTEx project published by the GTEx Consortium.

Additional Information

You and GTEx: Updated Informational Brochure

Visit the GTEx website for Donors and Families

For any questions, please contact Deborah Colantuoni at GTEXInfo@mail.nih.gov

Image of Genotype-Tissue Expression Project Tissue SamplingGTEx Symposium: All things considered — Biospecimens, 'Omics Data, and Ethical Issues. This 2 day symposium covered a broad range of topics that focus on the collection of normal biospecimens for GTEx. The symposium was open to the public. View the agenda. View the Symposium Website. View the archived videocast of Day 1 of Day 2.

GTEx Pilot Phase Data Show How Differences in DNA Affect Gene Activity and Disease Susceptibility. Analyses from the GTEx pilot phase were recently published in Science and other journals. Learn how the GTEx resource is poised to advance our understanding of how genetics and gene activity affect human health and disease. Read a brief summary of the potential of the GTEx resource and some of the pilot phase findings. Read the Press Release.

The Genotype-Tissue Expression Project (GTEx) Biospecimens Access Policy is a mechanism  to allow researchers access to tissues in the GTEx biobank. The policy and related forms can be found on the GTEx PortalExit Disclaimer Go directly to GTEx Sample Request Forms. Exit Disclaimer

See how many researchers are using the GTEx data from mid-2012 to mid-2013


The GTEx (Genotype-Tissue Expression) Project


The GTEx (Genotype-Tissue Expression) Project. Correlations between genotype and tissue-specific gene expression levels will help identify regions of the genome that influence whether and how much a gene is expressed. GTEx will help researchers to understand inherited susceptibility to disease and will be a resource database and tissue bank for many studies in the future.


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