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Program Snapshot

The NIH Common Fund’s Metabolomics program aims to increase national capacity in metabolomics by supporting the development of next generation technologies to enhance the sensitivity and speed with which specific elements of the cellular metabolome can be identified and quantified, providing training and mentoring opportunities, increasing the inventory of chemically identifiable metabolites through the synthesis and availability of high quality reference standards, and by promoting data sharing and collaboration.

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Program Highlights

Metablomics Highlight

NEW! Research from Metabolomics Program Mentored Research Scientist Dr. Mary Cloud Ammons provides insight into the unique metabolism of bacteria that colonize chronic wounds. Infection with bacterial communities contributes to the conversation of an acute wound to a chronic state. Using Nuclear Magnetic Resonance Spectrometry, Dr. Ammons and her colleagues looked at the metabolite composition of Staphylococcus aureus bacteria from two classes: Drug-resistant highly virulent bacteria obtained from clinical isolates and non-virulent drug-sensitive lab strains. For each strain, they analyzed samples grown in standard liquid cultures and others grown under biofilm conditions that mimic the chronic wound environment. They found that both bacterial strains exhibited distinct metabolite profiles when grown in the wound-like environment. These results suggest the possibility of developing molecular markers that could be used to classify the bacteria found within a wound and determine conversion to a chronic wound state. The nature of the metabolites also provide clues to the biological changes that occur when bacteria are grown in chronic wound conditions, offering the potential to develop therapeutic agents that exploit their distinct metabolism. View the article abstract here​.

Click on the image below to view Dr. Ammons' video contest submission that explains her research in plain language with the help of some animated bacteria!​

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Metabolomics of Bacterial Biofilms 

Studying the ebb and flow of biological molecules in the metabolism with metabolomics
Dr. Gary Patti and his team at the Washington University School of Medicine have built on recent advances in the fields of metabolomics and bioinformatics to develop a new approach to studying the ebb and flow of biological molecules as they are processed during metabolism. Their approach combines two techniques called “untargeted metabolomics analysis” and “isotopic labeling” that allow them to track the fate of a biological molecule in an unbiased manner. This publication describes their unique experimental process and introduces a new software program they’ve developed to make data analysis easier. They describe a test case which experimentally validates their system and demonstrates that it can be useful in identifying new biochemical pathways. Their system also allows us follow the fate of individual biological molecules in response to environmental changes. Read the article abstract here​.

Using metabolomics to understand the interplay of antibiotics and a pathogenic bacterium that can live in the gut:
Metabolomics Program Mentored Research Scientist Dr. Casey Theriot, utilizing the Michigan Regional Comprehensive Metabolomics Resource Center (MRC2 Exit Disclaimer), published in Nature Communications that metabolites produced by gut microbes change in response to antibiotic treatment and favor growth of the pathogenic bacterium C. difficile.

View the article abstract here.  Click here for Metabolomics Funded Research.

Researchers look at the relationship between metabolic health and the metabolites found in blood:
New work from the NIH West Coast Metabolomics Center at UC Davis describes how the metabolites found in the blood of women who are obese, sedentary and insulin-resistant change after the women participate in a weight loss and exercise intervention.  Some of the metabolites that changed were derived from the gut, and may have originated either from diet or from gut-dwelling microbes.  By revealing an association between improved metabolic health and an altered metabolite profile, this study and others like it could help us understand, diagnose and treat complex metabolic disorders like type 2 diabetes mellitus.  Click here Exit Disclaimer to access the research article.

Learn more about Metabolomics Initiatives
The NIH Common Fund is taking a comprehensive approach to increasing the research capacity in metabolomics by funding a variety of initiatives in this area, including training, technology development, standards synthesis, and data sharing capability for this new field.
View the Metabolomics Press Release.
 

Learn more about the Metabolomics Community

 

NEW! The metabolomeXchange: the beginnings of international metabolomics data sharing. Four databases are now accessible from the metabolomeXchange including the Metabolomics Workbench funded by the Common Fund. Check it out at: http://metabolomexchange.org/. Exit Disclaimer

Metabolomics Symposium & Workshop: July 27 & July 28-August 8, 2014, University of Kentucky, Lexington. The one-day symposium on July 27 will feature leaders in the stable isotope-resolved metabolomics field as well as researchers from around the world who are successfully using this technique to further their individual studies. The 12-day workshop is appropriate for graduate students, technicians, postdocs, and faculty who wish to integrate stable isotope-enabled studies of metabolism into their experimental design. Click here for more information and to register. Exit Disclaimer 

NEW! Registration Open for the August 22, 2014 Metabolomics Symposium at RTI International. Co-sponsored by the NIH Eastern Regional Comprehensive Metabolomics Core at RTI International and Waters Corporation. Keynote Speakers: Dr. Daniel Shaughnessy, NIEHS; Dr. Robert Plumb; Waters Corporatio and Imperial College. For more information or to register, click here. Exit Disclaimer 

Mayo Clinic Metabolomics Symposium: Sept. 8-10, 2014, Rochester, Minn.​ This symposium will present translational science investigators, KL2 and other K-award scholars, and research fellows new to the metabolomics field an opportunity to explore the latest information on metabolomics and network with colleagues and world-recognized experts in the field.​ Click here for more information and to register. Exit Disclaimer 

NIH Common Fund Annual Meeting: Metabolomics. 
Not open to the public. The NIH Eastern Regional Comprehensive Metabolomics Resource Core at RTI International (RTI RCMRC) is hosting the NIH Common Fund Annual Meeting on October 29 and 30. The event will take place at the National Institute of Environmental Health Sciences (NIEHS), located at in Research Triangle Park, NC. The meeting is open to NIH Metabolomics Consortium members only. For more information, click here.

Nominations now being accepted for metabolite standards to be synthesized by the NIH’s Common Fund Metabolomics program. Read More . . . Exit Disclaimer

 

For Metabolomics Data and Resources visit the Metabolomics Workbench  Exit Disclaimer

The NIH Common Fund’s Increasing Metabolomic Research Capacity program components and goals:

Increasing Metabolomic Research Capacity program components and goals

 

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