We Accelerate Discovery

You are here

Printer

Program Snapshot

The NIH Common Fund’s Metabolomics program aims to increase national capacity in metabolomics by supporting the development of next generation technologies to enhance the sensitivity and speed with which specific elements of the cellular metabolome can be identified and quantified, providing training and mentoring opportunities, increasing the inventory of chemically identifiable metabolites through the synthesis and availability of high quality reference standards, and by promoting data sharing and collaboration.

Learn more here

Program Highlights

Metablomics Highlight

NEW! Research from Metabolomics Program Mentored Research Scientist Dr. Mary Cloud Ammons provides insight into the unique metabolism of bacteria that colonize chronic wounds. Infection with bacterial communities contributes to the conversion of an acute wound to a chronic state. Using Nuclear Magnetic Resonance Spectrometry, Dr. Ammons and her colleagues looked at the metabolite composition of Staphylococcus aureus bacteria from two classes: Drug-resistant highly virulent bacteria obtained from clinical isolates and non-virulent drug-sensitive lab strains. For each strain, they analyzed samples grown in standard liquid cultures and others grown under biofilm conditions that mimic the chronic wound environment. They found that both bacterial strains exhibited distinct metabolite profiles when grown in the wound-like environment. These results suggest the possibility of developing molecular markers that could be used to classify the bacteria found within a wound and determine conversion to a chronic wound state. The nature of the metabolites also provide clues to the biological changes that occur when bacteria are grown in chronic wound conditions, offering the potential to develop therapeutic agents that exploit their distinct metabolism. View the article abstract here​.

Click on the image below to view Dr. Ammons' video contest submission that explains her research in plain language with the help of some animated bacteria!​

Exit Disclaimer
Metabolomics of Bacterial Biofilms 

Studying the ebb and flow of biological molecules in the metabolism with metabolomics
Dr. Gary Patti and his team at the Washington University School of Medicine have built on recent advances in the fields of metabolomics and bioinformatics to develop a new approach to studying the ebb and flow of biological molecules as they are processed during metabolism. Their approach combines two techniques called “untargeted metabolomics analysis” and “isotopic labeling” that allow them to track the fate of a biological molecule in an unbiased manner. This publication describes their unique experimental process and introduces a new software program they’ve developed to make data analysis easier. They describe a test case which experimentally validates their system and demonstrates that it can be useful in identifying new biochemical pathways. Their system also allows us follow the fate of individual biological molecules in response to environmental changes. Read the article abstract here​.

Learn more about Metabolomics Initiatives
The NIH Common Fund is taking a comprehensive approach to increasing the research capacity in metabolomics by funding a variety of initiatives in this area, including training, technology development, standards synthesis, and data sharing capability for this new field.
View the Metabolomics Press Release.
 

Learn more about the Metabolomics Community

 

NEW! Metabolomics introduction and training: training materials and videos from the 2014 University of Florida Metabolomics Workshop & Symposium are now available on the Metabolomics Workbench Online Training and Education page. Exit Disclaimer

Learn about using Isotope Tracers in Metabolic Research, November 10-14, 2014, in an annual course sponsored by the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): http://www.mmpc.org/shared/tracers.aspx​Exit Disclaimer

The metabolomeXchange: the beginnings of international metabolomics data sharing. Four databases are now accessible from the metabolomeXchange including the Metabolomics Workbench funded by the Common Fund. Check it out at: http://metabolomexchange.org/. Exit Disclaimer

NIH Common Fund Annual Meeting: Metabolomics. Not open to the public. The NIH Eastern Regional Comprehensive Metabolomics Resource Core at RTI International (RTI RCMRC) is hosting the NIH Common Fund Annual Meeting on October 29 and 30. The event will take place at the National Institute of Environmental Health Sciences (NIEHS), located at in Research Triangle Park, NC. The meeting is open to NIH Metabolomics Consortium members only. For more information, click here.

Learn more about the strengths of each NIH-funded metabolomics resource core hereExit Disclaimer

Nominations now being accepted for metabolite standards to be synthesized by the NIH’s Common Fund Metabolomics program. Read More . . . Exit Disclaimer

 

For Metabolomics Data and Resources visit the Metabolomics Workbench  Exit Disclaimer

The NIH Common Fund’s Increasing Metabolomic Research Capacity program components and goals:

Increasing Metabolomic Research Capacity program components and goals

 

Up to Top