The Common Fund's Epigenomics Program includes a series of complementary initiatives aimed at generating new research tools, technologies, datasets, and infrastructure to accelerate our understanding of how genome-wide chemical modifications to DNA regulate gene activity without altering the DNA sequence itself and what role these modifications play in health and disease.
Double Meaning: Researchers Discover "Hidden Code" in Genes
Jumping genes have a job to do
Common Fund Researchers Detail Epigenomic Changes during Development
Epigenomics researchers publish new study linking genetic variation and gene regulation in many common diseases
Cell Snapshot of Histone Marks
Epigenomics researcher Dr. Yingming Zhao has published a Cell Snapshot summarizing all known histone marks from human, mouse, and rat. Dr. Zhao's group discovered a significant proportion of the 400 currently known marks. Many histone marks play important roles in regulating gene expression, and identifying and understanding the specific functions of each of these marks will enable research into many aspects of human health and disease.
View the Cell Snapshot: Histone Modifications
Tips and Tools for Using Epigenomics Resources
ENCODE/Roadmap Epigenomics Tutorial
Overview of Epigenomics program resources
Watch Epigenomics grantee John Stamatoyannopoulos’ lecture “A Roadmap to the Living Genome,” in which he presents research describing new epigenomic maps for a wide variety of normal human cell/tissue types; insights into the genomic patterning of epigenomic features; and encoding of cellular state, maturity, and fate information within epigenomic landscapes.
Watch “A Roadmap to the Living Genome” video here.
Download slides from the Epigenomics presentation to the NIH Council of Councils
Download slides here.