Molecular Transducers of Physical Activity in Humans Health Relevance

The first year of funding for the Common Fund’s Molecular Transducers of Physical Activity program is currently underway. Although hundreds of studies show that physical activity provides benefit to virtually every aspect of health, the molecular mechanisms underlying these benefits are poorly understood.  The Common Fund is in a unique position to be able to bring together scientists from diverse fields (exercise physiology, genetics, biochemistry, and computation biology) that will be required to discover and interpret the changes that occur in people in response to exercise. The consortium is currently working to develop protocols for pilot studies to determine the molecular mechanisms of how physical activity benefits human health.  Over the course of the program, up to 3,000 participants across the country from diverse cultural and ethnic backgrounds with varying degrees of physical activity will participate in the study to generate a molecular map of changes that occur with physical activity. The data collected will be supplemented by studies in a rodent model, allowing for exploration of molecular changes in tissues not accessible in human participants. This molecular map will be available for researchers to explore, permitting them to study their target of interest in relation to the benefits of physical activity.   In the future, this knowledge should allow researchers and doctors to develop individually targeted exercise recommendations as well as develop therapeutics for those unable to exercise.

NIH Director Dr. Collins Discusses The Physical Activity Program


What May We Find Out?

A goal of the Molecular Transducers of Physical Activity in Humans Program is to identify how the molecules within our bodies change following physical activity. Researchers across the country can then use this information to better understand how physical activity can benefit our health. By moving your mouse over the yellow circles you can see some questions that may be addressed through this research. The Clinical Centers will recruit participants for an exercise program as part of the study.

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How To Get Involved

Are you interested in participating in the MoTrPAC study? The map below shows the location for all of the involved centers. Move your mouse over the center you are interested in and the locations and names will appear on the map. Make sure to check out Clinical Centers to learn more about recruitment, important study information, and how to get involved!

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This page last reviewed on August 28, 2018