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Program Snapshot

Genetic material, located within the nucleus of a cell, is not randomly organized.  Although the spatial configuration of DNA and DNA-associated proteins is known to influence gene expression and cellular function, how this occurs is currently unknown. The Common Fund’s 4D Nucleome program aims to understand the principles behind the three-dimensional organization of the nucleus in space and time (the 4th dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.

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Program Highlight

The Common Fund Launches New 4D Nucleome Program

NEW! Read the press release announcing the 4D Nucleome program and other new Common Fund programs! NIH programs to focus on emerging areas of science

During the 2013-2014 Common Fund strategic planning process, the NIH community identified the need to understand how nuclear organization in space and time affects cellular function in health and disease. Recent advances in our understanding of genomics and epigenomics, coupled with technological breakthroughs in tools and methods to study and manipulate nuclear architecture, provide the opportunity to catalyze this nascent field of research. The Common Fund is launching the 4D Nucleome program to address these identified needs and opportunities.



NEW! Informational Webinar: 4D Nucleome Initiatives

Program Staff associated  with the new NIH Common Fund “4D Nucleome” Program will organize a webinar for potential applicants to the six 4DN FOAs on Monday, November 10th at 12 noon Eastern Time.

Background information about the 4DN Program will be presented by NIH staff, with most of the time dedicated to answering questions from potential applicants. If you are interested in participating, please let us know by email at 4DNucleome@mail.nih.gov . You may also email your questions ahead of time in order to facilitate the discussion. Call-in information and webinar instructions will be made available through this website one week before the webinar.

4D Nucleome Program Announces First Funding Opportunities

The NIH has issued six Funding Opportunity Announcements for the 4D Nucleome program. For more information and details on how to apply, click the links below.

  • Nuclear Organization and Function Interdisciplinary Consortium (NOFIC) (U54) (RFA-RM-14-006): NOFIC will be composed of multidisciplinary teams that will develop and validate novel approaches and genome-wide mapping technologies that will lead to a deeper understanding of nuclear organization in time and space, and the role of this organization in regulating gene expression programs.
  • Nucleomics Tools (U01) (RFA-RM-14-007): This initiative will stimulate the development and validation of chemical and biochemical technologies for measuring three dimensional interactions between specific places in the genome (genomic loci), or between genomic loci and regulators of genome organization and function, in mammalian cells.
  • Study of Nuclear Bodies and Compartments (U01) (RFA-RM-14-008): This initiative will support the development of tools and strategies to study the three dimensional architecture of the nucleus in relationship to the spatial arrangement of nuclear bodies and molecular machinery regulating gene expression, the structure and function of poorly characterized nuclear structures and compartments, and the role of specialized proteins and RNAs in nuclear organization and function.
  • 4D Nucleome Imaging Tools (U01) (RFA-RM-14-009): This initiative will stimulate the development of higher throughput, higher resolution and higher content imaging approaches that can measure changes in nuclear organization in live single cells.
  • 4D Nucleome Network Organizational Hub (U01) (RFA-RM-14-010): The 4DN-OHwill develop a community website to facilitate sharing of data, reagents, standards, and protocols; foster collaborations; organize yearly scientific meetings; and oversee administrative aspects of the program. 4DN-OH will also administer the Opportunity Pool, a fund to support new projects and initiatives that address identified needs arising throughout the lifetime of the program.
  • 4D Nucleome Network Data Coordination and Integration Center (U01) (RFA-RM-14-011): 4DN-DCIC will track, store, and display all data generated by 4D Nucleome investigators; provide a Data Analysis Center to assist with integrated analyses; develop metrics and standards to be adopted by the community at large; and provide visualization tools to facilitate access and understanding of complex datasets.




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