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Program Snapshot

The Common Fund’s Protein Capture Reagents program is developing new resources and tools to understand the critical role the multitude of cellular proteins play in normal development and health as well as in disease. These resources will support a wide-range of research and clinical applications that will enable the isolation and tracking of proteins of interest and permit their use as diagnostic biomarkers of disease onset and progression.

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Program Highlights

Using DNA for More than Genetic InformationImage of drug molecules binding aptamers.

Tiny chains of DNA molecules that fold up into variety of 3-dimensional shapes that recognize and bind to a whole host of biological molecules are called aptamers.  Protein Capture Reagents Program grantee Dr. H. Tom Soh and colleagues developed a way to make apatmers quickly and have used aptamers in a new device to track the drug levels in an animal’s bloodstream in real time.

Learn more about apatmers here.

Image source: From Ferguson et al. Sci Transl Med 5, 213ra165 (2013). Reprinted with permission from AAAS.

Program Initiatives

NIH Common Fund Supports Initiatives for the Development of Protein Capture Reagents and Technologies

The NIH Common Fund Protein Capture Reagents Program makes six new awards in fiscal year 2011 to accelerate the development of a renewable affinity reagent resource for human transcription factors, and technology for new affinity reagents against the human proteome. The projects address the pressing need for new resources and tools to understand the critical role the multitude of cellular proteins play in normal development and health as well as in disease.

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View the awards…

See: ProteinCapture.org Exit Disclaimer for the reagents that are currently available.

NEW! The Protein Capture Reagents Program data portal goes live. Researchers can find information on publicly-available affinity reagents for human transcription factors including: antigen source, binder type, performed validations and links to distributors.
Protein Capture Reagents Data Portal Exit Disclaimer
 

International Collaboration on Protein Affinity Reagents
The Protein Capture Reagents Program, part of the NIH Office of the Director, signed a Memorandum of Understanding (MOU) with the Affinomics Exit Disclaimer consortium and the Human Protein AtlasExit Disclaimer The purpose of the MOU is to set up cooperative activities in the production and use of protein affinity reagents. The NIH and these European programs have unique missions but many common goals. The cooperation guided by this MOU should benefit all programs and the main goal of generating valuable resources for protein affinity reagents for the scientific community.

“Calling the Next Generation of Affinity Reagents”
Nature Methods reports on efforts by the NIH Common Fund Protein Capture Reagents Program and scientists around the world to fill the need for renewable and reliable affinity reagents that can detect and isolate specific protein molecules. Scientists are refining and validating older technologies or designing all new ones to provide biomedical researchers with high-quality affinity reagents. Find out how high-throughput methods are being combined with technologies ranging from traditional antibody proteins to engineered nucleic acid/protein hybrids to address this important hurdle for biomedical discovery. Read the article Exit Disclaimer

Schematic of Protein Capture Reagents program components
Schematic of Protein Capture Reagents program components
 

 

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