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Program Snapshot

The Common Fund’s Protein Capture Reagents program is developing new resources and tools to understand the critical role the multitude of cellular proteins play in development, health, and disease. These resources will support a wide-range of research and clinical applications by enabling the isolation and tracking of proteins of interest.

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Program Highlights

Standardizing Antibody Quality

Antibodies are a crucial component in multiple cell biology applications, but there are currently no standardized methods to assess antibody quality. Researchers, including awardee Anthony Kossiakoff, developed a standard operating procedure (SOP) using mass spectrometry to quantitatively assess antibodies used in immunoprecipitation experiments (IP-MS), representing a major step toward standardizing antibody quality.

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The Need for Standardized Antibodies in Research

Two op-ed pieces in Nature and Nature Methods discuss the importance of standardizing antibodies by improving antibody quality and performance in order to enhance reproducibility in biomedical research.

Using DNA for More than Genetic Information

Image of drug molecules binding aptamers.Tiny chains of DNA molecules that fold up into variety of 3-dimensional shapes that recognize and bind to a whole host of biological molecules are called aptamers.  Protein Capture Reagents Program grantee Dr. H. Tom Soh and colleagues developed a way to make apatmers quickly and have used aptamers in a new device to track the drug levels in an animal’s bloodstream in real time.

Learn more about apatmers here.

Image source: From Ferguson et al. Sci Transl Med 5, 213ra165 (2013). Reprinted with permission from AAAS.

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Schematic of Protein Capture Reagents program components
Schematic of Protein Capture Reagents Program Components

Protein Capture Reagents Program Data Portal Exit Disclaimer

Find information on available affinity reagents for human transcription factors generated by the Protein Capture Reagents Program, including antigen source, binder type, performed validations, and links to distributors.

NEW! Request for Information (RFI) from Protein Capture Reagents Program

The Protein Capture Reagent Program has released a Request for Information (RFI) to obtain community Input on Validation Assays for Affinity Reagents Generated by the NIH Common Fund Protein Capture Reagents Program.

  • Responses are due October 20, 2015
  • Comments must be submitted to: proteincapture@mail.nih.gov

In the News

CDI Laboratories Showcased at White House Demo Day

The biotech startup CDI Laboratories Exit Disclaimer, whose system of monoclonal antibody production is part of the Protein Capture Reagents program, was showcased at the first-ever White House Demo Day held on August 4, 2015. Ignacio Pino, president of CDI Laboratories, was invited to the White House to represent his company, which produces research-grade protein and antibody products. Pino founded the company in 2008, with Heng Zhu, Seth Blackshaw, Jef Boeke, Dan Eichinger and Joe Bonaventura.

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