The Common Fund’s Protein Capture Reagents program is developing new resources and tools to understand the critical role the multitude of cellular proteins play in normal development and health as well as in disease. These resources will support a wide-range of research and clinical applications that will enable the isolation and tracking of proteins of interest and permit their use as diagnostic biomarkers of disease onset and progression.
Using DNA for More than Genetic Information
Tiny chains of DNA molecules that fold up into variety of 3-dimensional shapes that recognize and bind to a whole host of biological molecules are called aptamers. Protein Capture Reagents Program grantee Dr. H. Tom Soh and colleagues developed a way to make apatmers quickly and have used aptamers in a new device to track the drug levels in an animal’s bloodstream in real time.
Learn more about apatmers here.
Image source: From Ferguson et al. Sci Transl Med 5, 213ra165 (2013). Reprinted with permission from AAAS.
NIH Common Fund Supports Initiatives for the Development of Protein Capture Reagents and Technologies
The NIH Common Fund Protein Capture Reagents Program makes six new awards in fiscal year 2011 to accelerate the development of a renewable affinity reagent resource for human transcription factors, and technology for new affinity reagents against the human proteome. The projects address the pressing need for new resources and tools to understand the critical role the multitude of cellular proteins play in normal development and health as well as in disease.
See: ProteinCapture.org for the reagents that are currently available.
Schematic of Protein Capture Reagents program components