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Figure 2 of "Lumbar Imaging With Reporting Of Epidemiology (LIRE)—Protocol for a pragmatic cluster randomized trial"Study Design of LIRE Pragmatic Trial Published

Dr. Jerry Jarvik and colleagues have published an article in Contemporary Clinical Trials describing the design of the Lumbar Imaging With Reporting of Epidemiology (LIRE Exit Disclaimer) trial. The trial is being supported by the HCS Research Collaboratory as a demonstration project. Read a brief summary of the article Exit Disclaimer in plain language. Read the original article abstract.

Reference:

Lumbar Imaging With Reporting Of Epidemiology (LIRE)-Protocol for a pragmatic cluster randomized trial. Jarvik JG, Comstock BA, James KT, Avins AL, Bresnahan BW, Deyo RA, Luetmer PH, Friedly JL, Meier EN, Cherkin DC, Gold LS, Rundell SD, Halabi SS, Kallmes DF, Tan KW, Turner JA, Kessler LG, Lavallee DC, Stephens KA, Heagerty PJ. Contemporary Clinical Trials. doi: 10.1016/j.cct.2015.10.003. [Epub ahead of print] October 19, 2015.

 

 

 

Findings from STOP CRC on Pragmatic Trial Recruitment

Drs. Coronado and Green, lead researchers of the Strategies and Opportunities to Stop Colorectal Cancer in Priority Populations (STOP CRC Exit Disclaimer) pragmatic trial demonstration project, and colleagues have published an article in Clinical Trials describing the challenges of recruiting participants into large, multi-site pragmatic clinical trials—particularly at the health system level. Read a brief summary of the article Exit Disclaimer in plain language. Read the original article abstract.

Reference:

Recruiting community health centers into pragmatic research: Findings from STOP CRC. Coronado GD, Retecki S, Schneider J, Taplin SH, Burdick T, Green BB. Clinical Trials. 2015 Sep 29. pii: 1740774515608122. [Epub ahead of print].

 

 

Video of Dr. Josephine Briggs Stakeholder Interview about the HCS Research CollaboratoryInterview with Dr. Josephine Briggs on the Impact of HCS Research Collaboratory

Click on the image at right to watch an interview with the Director of the NIH National Center for Complementary and Integrative Health (NCCIH) as she describes the impact of the HCS Research Collaboratory and its collaborators. Exit Disclaimer

 

 

 

Collaboratory Researchers Find Poor Compliance with Clinical Trials Reporting Law

A new analysis of data from the ClinicalTrials.gov website shows that despite federal laws requiring the public reporting of results from clinical trials, most research sponsors fail to do so in a timely fashion — or, in many cases, at all. The study, published in the New England Journal of Medicine, was conducted by researchers supported by the NIH Collaboratory and the Clinical Trials Transformation Initiative (CTTI). A brief description of the findings is available in the Collaboratory's Living Textbook "Rethinking Clinical Trials." Exit Disclaimer The original research article was published in The New England Journal of Medicine. The article abstract is freely available. Exit Disclaimer

 

Ethical and Regulatory Challenges for Pragmatic Cluster Randomized Trials

A new report by researchers from the NIH Collaboratory explores some of the challenges facing physicians, scientists, and patient groups who are working to develop innovative methods for performing clinical trials. A brief description of the report is available in the Collaboratory's Living Textbook "Rethinking Clinical Trials." Exit Disclaimer  The original research article was published in the journal Clinical Trials. The article abstract is freely available. Exit Disclaimer

 

"A guide to research partnerships for pragmatic clinical trials."

The HCS Research Collaboratory's Systems Interactions Core just published a paper that highlights multiple lessons about building strong research partnerships between health researchers and healthcare systems.

Read the full article in The BMJ. Exit Disclaimer
Supplemental Material is available in the Collaboratory's Living Textbook. Exit Disclaimer

 

Groundbreaking Suicide Study

An HCS Research Collaboratory Demonstration Project will help researchers learn more about ways to treat people experiencing suicidal thoughts. Nearly 20,000 patients will be able to participate in a trial that draws from other successful interventions for depression and suicide. One of the treatments being tested was developed with the help of other patients. 

Read the Science Update from the National Institute of Mental Health about the "Pragmatic Trial of Population-Based Programs to Prevent Suicide Attempt" Demonstration Project.
Get Detailed Information on the Demonstration Project from the HCS Research Collaboratory website. Exit Disclaimer

 

Large data networks important tools for public health and research needsLarge Data Networks to Support Public Health and Research

HCS Research Collaboratory grantee, Dr. Richard Platt, and his colleagues published an article in Health Affairs profiling four large health data networks. The networks are “examples of the first stage in the development of a shared national big-data resource that leverages the investments of many agencies and organizations for the benefit of multiple networks and users.” Read a summary of the article Exit Disclaimer in plain language. Read the original article abstract Exit Disclaimer (full text requires subscription).

Reference:

Four Health Data Networks Illustrate the Potential for a Shared National Multipurpose Big-Data Network. Curtis LH, Brown J, Platt R. Health Affairs. July 2014, vol. 33, no. 7, 1178-1186.

 

Kids Say the Darndest Things: Now They're Talking About Colon Cancer

STOP Colon Cancer Demonstration Project

This HCS Collaboratory Demonstration Project learned valuable lessons from a pilot study about promoting cancer screening among minority and low-income populations.

Read the National Public Radio "Shots Blog" post about the project. Exit Disclaimer
Click on the image at right to watch a fun & educational video about the project.
Read the original research article in BMC Cancer. Exit Disclaimer

 

Electronic Health Records and Pragmatic Clinical Trials

In a recent article in the Journal of the American Medical Informatics Association the HCS Research Collaboratory describes the challenges and opportunities faced in using electronic health records when conducting pragmatic clinical trials.

Read a brief description of the article from the HCS Collaboratory here. Exit Disclaimer

 

Improving Medical Research Studies through Participant Feedback

HCS Research Collaboratory steering committee chairman Barry Coller, M.D., recently published an article in the New England Journal of Medicine on how medical research participants’ experiences could be used to improve the planning process for medical research studies.

Read a brief description of the article from the HCS Collaboratory here. Exit Disclaimer

 

 

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