Tissue Resident Memory T Cells (TRM) generated by skin vaccination

Vaccination to generate protective tissue resident T cells

Vaccination through skin generates long-lived memory T cells, included central memory (TCM) and effector memory (TEM) T cells. Some of these memory T cells migrate into peripheral tissues, including skin, lung, and gastrointestinal tract, and become resident long-lived memory T cells (TRM) that protect against infection.