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The goal of the Gabriella Miller Kids First Pediatric Research Program (Kids First) is to help researchers uncover new insights into the biology of childhood cancer and structural birth defects, including the discovery of shared genetic pathways between these disorders. Visit the Kids First program page and the Kids First Data Resource Portal to learn more.

CFDE Engagement Award: OD030162

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to accelerate development of therapeutic devices that modulate electrical activity in nerves to improve organ function. Visit the SPARC program page and the SPARC Portal to learn more.

CFDE Engagement Award: OD030164

The goal of the Human BioMolecular Atlas Program (HuBMAP) is to develop an open and global platform to map healthy cells in the human body. Visit the HuBMAP program page and the HuBMAP Consortium webpage to learn more.

CFDE Engagement Award: OD030545

The Extracellular RNA Communication (ExRNA) program is working to understand extracellular RNA biology and accelerate development of potential therapeutics and diagnostics. Visit the ExRNA program page and the ExRNA Research Portal to learn more.

CFDE Engagement Award: OD030547

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to uncover at the molecular level how exercise improves and preserves the health of the body’s tissues and organs. Visit the MoTrPAC program page and MoTrPAC Data Hub to learn more.

The goal of the 4D Nucleome Data (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). Visit the 4DN program page and the 4D Nucleome Web Portal to learn more.

CFDE Engagement Award: OD032119

The Human Microbiome Project (HMP) developed research resources to enable the study of the microbial communities that live in and on our bodies and the roles they play in human health and disease. Visit the HMP program page and the HMP Data Portal to learn more.

Metabolomics is the study of the chemical reactions that occur in organisms, cells, or tissues and the small chemicals (metabolites) that are produced as a result. The Metabolomics program aims to catalyze science around the role of metabolomics in human health. Visit the Metabolomics program page and the Metabolomics Workbench to learn more.

CFDE Engagement Award: OD030544

The goal of the Illuminating the Druggable Genome (IDG) program is to identify and provide information on proteins that are currently not well studied within commonly drug-targeted protein families. Visit the IDG program page and the IDG Consortium to learn more.

CFDE Engagement Award: OD030546

The Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a library that catalogs changes that occur when different types of cells are exposed to a variety of agents that disrupt normal cellular functions, called “perturbagens.” Visit the LINCS program page and the LINCS Consortium to learn more.

CFDE Engagement Award: OD030160

The Genotype-Tissue Expression (GTEx) program established a data resource and tissue bank to study the relationship between genetic variants (inherited changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals. GTEx is also examining how gene expression varies between male and female. Visit the GTEx program page and the GTEx Portal to learn more.

CFDE Engagement Award: OD030161

The goal of the Common Fund’s Glycoscience program is to create new resources, tools, and method to make the study of glycans (sugars) more accessible to the broader research community. Visit the Glycoscience program page and the GlyGen webpage to learn more.

CFDE Engagement Award: OD032092

Gene Centric Prototype Dashboard

This project will develop methods to harmonize gene, protein, and RNA identifiers and generate a cloud workspace that pools gene information from DCCs for use cases. Learn more on the CFDE Highlights page.

CLinical Observations and Vocabularies (CLOVoc)

This project will build FAIR metadata about human clinical data to improve the ability to query across and integrate different datasets so that they are interoperable and reusable for secondary analyses. Learn more on the CFDE Highlights page.

Aggregation and Sharing of Variant-centric Information

This project aims to make CFDE variant data FAIR by establishing a framework to derive information about specific variants and regulatory elements from the high-volume -omics profiling datasets to interpret such non-coding variants. Learn more on the CFDE Highlights page.

Toxicology Screening Pipeline

This project will develop a pipeline infrastructure that will tag CFDE Portal records for genes, gene products, and small molecules with labels of toxicity potential for reproductive and developmental processes. Learn more on the CFDE Highlights page.

The Common Fund Data Ecosystem (CFDE) is enhancing the ability to ask scientific questions across data sets. Visit the CFDE Portal to learn more.

CFDE Coordinating Center Award: OD025459

Future Eligible Data Coordinating Centers

In January 2020, the Common Fund released an Engagement Opportunity Announcement (OTA-20-005) for eligible DCCs to engage with the CFDE Coordinating Center and other DCCs to establish the CFDE. For more details, please view the Engagement Opportunity Announcement and Process for Rolling Submission of Engagement Opportunity Award Plans.