Somatic Cell Genome Editing Consortium

Map showing icons in locations indicated in the list
Clickable icon Baylor College of Medicine
Clickable icon Beth Israel Deaconess Medical Center
close x Delivery Technologies for In Vivo Genome Editing

Bioengineered red blood cells as extracellular vesicle-mediated delivery platforms for gene editing machinery
Clickable icon Broad Institute
close x Novel AAVs engineered for efficient and noninvasive cross-species gene editing throughout the central nervous system"

Expanding the Scope of Base Editing
Clickable icon Case Western Reserve University
close x In vivo delivery of CRISPR Cas9-guide RNA nucleoprotein complexes using the nanoPOD platform
Clickable icon Columbia University Health Sciences
close x Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative Disorders
Clickable icon Duke University
close x Microphysiological Human Tissue Systems for Monitoring of Genome Editing Outcomes

Evolving High Potency AAV Vectors for Neuromuscular Genome Editing

Epigenome Editing Technologies for Treating Diverse Disease
Clickable icon The Georgia Institute of Technology
close x Highly Specific ZFN-Based HSC Gene Editing Therapies Identified By In Vivo Barcode Nanoparticle Screens And Rationally Designed Mrna
Clickable icon J. David Gladstone Institutes
close x Human microtissues for in situ detection and functional measurement of adverse consequences caused by genome editing
Clickable icon Jackson Laboratory
close x The Jackson Laboratory Gene Editing Testing Center (JAX-GETC)
Clickable icon Johns Hopkins University
close x Non-Invasive Tracking of Genome-Corrected iPS cells in ALS
Clickable icon Massachusetts Ear and Eye Infirmary
close x Efficient in Vivo RNP-based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid Nanoparticles
Clickable icon Massachusetts General Hospital
close x Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editing
Clickable icon Massachusetts Institute of Technology
close x Knockin marmoset reporters for non-invasive measuring of genome-editing efficiency
Clickable icon Mayo Clinic
close x Building the mitochondrial genome editing repertoire
Clickable icon Medical College of Wisconsin
close x Dissemination and Coordinating Center for the SCGE Consortium
Clickable icon The Ohio State University
close x Development of a nanoparticle-based gene editing technology for neurological applications
Clickable icon Oregon Health & Science University
close x Rhesus Macaque Somatic Cell Gene Editing Resource
Clickable icon Recombinetics, Inc.
close x Development of Swine Reporter Models for Testing Somatic Cell Genome Editing Tools
Clickable icon Rice University
close x Velcro AAV Vector for tissue-specific delivery of genome editing reagents with enhanced cargo capacity
Clickable icon St. Jude Children’s Research Hospital
close x A novel human T-cell platform to define biological effects of genome editing
Clickable icon Texas Tech University Health Sciences Center
close x Novel CRISPR-Cas9 protein delivery to T cells in vivo by targeting CD7
Clickable icon University of California, Berkeley
close x Molecular MRI for in vivo tracking of gene editing and gene edited cells

Cas9 RNP delivery to immune cells in vivo via molecular targeting

Expanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systems
Clickable icon University of California, Davis
close x Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools

Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo

Cell-specific nanocarrier with endocytic and endosomolytic activities for therapeutic genome editing
Clickable icon University of Connecticut SCH of MED/DNT
close x Human cardiac microtissues with innate immune sensing to study adverse consequences of genome editing
Clickable icon The University of Iowa
close x Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides
Clickable icon University of Massachusetts MED SCH
close x Develop combinatorial non-viral and viral CRISPR delivery for lung diseases

Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors
Clickable icon University of Missouri, Columbia
close x Swine Somatic Cell Genome Editing (SCGE) Center
Clickable icon University of Pittsburgh
Clickable icon University of Washington
close x Improving the Safety of Genome Editing With Human Kidney Organoids
Clickable icon University of Western Ontario
close x Non-Invasive Monitoring of CRISPR/Cas-Edited Chimeric Antigen Receptor T (CAR-T) Cells with Reporter Gene-Based Magnetic Resonance Imaging and Positron Emission Tomography
Clickable icon University of Wisconsin–Madison
close x Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids

Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
Clickable icon Washington University
close x Endothelial-targeted adenovirus for organ-selective gene editing in vivo
Clickable icon Yale University
close x Poly(amine-co-ester)s for Targeted Delivery In Vivo of Gene Editing Agents to Bone Marrow and Lung

Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brain

PNA Nanoparticles for Gene Editing In Vivo