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The goal of the Gabriella Miller Kids First Pediatric Research Program (Kids First) is to help researchers uncover new insights into the biology of childhood cancer and structural birth defects, including the discovery of shared genetic pathways between these disorders. Visit the Kids First program page and the Kids First Data Resource Portal to learn more.

CFDE Engagement Award: OD030162

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to accelerate development of therapeutic devices that modulate electrical activity in nerves to improve organ function. Visit the SPARC program page and the SPARC Portal to learn more.

CFDE Engagement Award: OD030164

The goal of the Human BioMolecular Atlas Program (HuBMAP) is to develop an open and global platform to map healthy cells in the human body. Visit the HuBMAP program page and the HuBMAP Consortium webpage to learn more.

CFDE Engagement Award: OD030545

The Extracellular RNA Communication (ExRNA) program is working to understand extracellular RNA biology and accelerate development of potential therapeutics and diagnostics. Visit the ExRNA program page and the ExRNA Research Portal to learn more.

CFDE Engagement Award: OD030547

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to uncover at the molecular level how exercise improves and preserves the health of the body’s tissues and organs. Visit the MoTrPAC program page and MoTrPAC Data Hub to learn more.

The goal of the 4D Nucleome Data (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). Visit the 4DN program page and the 4D Nucleome Web Portal to learn more.

The Human Microbiome Project (HMP) developed research resources to enable the study of the microbial communities that live in and on our bodies and the roles they play in human health and disease. Visit the HMP program page and the HMP Data Portal to learn more.

Metabolomics is the study of the chemical reactions that occur in organisms, cells, or tissues and the small chemicals (metabolites) that are produced as a result. The Metabolomics program aims to catalyze science around the role of metabolomics in human health. Visit the Metabolomics program page and the Metabolomics Workbench to learn more.

CFDE Engagement Award: OD030544

The goal of the Illuminating the Druggable Genome (IDG) program is to identify and provide information on proteins that are currently not well studied within commonly drug-targeted protein families. Visit the IDG program page and the IDG Consortium to learn more.

CFDE Engagement Award: OD030546

The Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a library that catalogs changes that occur when different types of cells are exposed to a variety of agents that disrupt normal cellular functions, called “perturbagens.” Visit the LINCS program page and the LINCS Consortium to learn more.

CFDE Engagement Award: OD030160

The Genotype-Tissue Expression (GTEx) program established a data resource and tissue bank to study the relationship between genetic variants (inherited changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals. GTEx is also examining how gene expression varies between male and female. Visit the GTEx program page and the GTEx Portal to learn more.

CFDE Engagement Award: OD030161

Novel Insights into Complex Conditions

Novel insights into complex conditions—generating multi-layered organ maps that will incorporate genetic mutations, structural birth defects, and gene activity changes during development, to create a powerful tool for studying complex conditions like Down syndrome. Visit the CFDE Highlights page for the latest CFDE research highlights.

New Drug Targets for Pediatric Cancer Treatments

New drug targets for pediatric cancer treatments—identifying new potential therapeutic targets for specific types of pediatric cancers by comparing the gene activity differences between tumors and healthy organ tissue. Visit the CFDE Highlights page for the latest CFDE research highlights.

Data-Driven Treatment Planning

Data-driven treatment planning—coupling drug and small molecule predictions with patient gene activity data to uncover key molecular pathways and help with developing effective treatment strategies, predicting drug responses, identifying the best candidate drugs for specific patients, and tracking disease progression and recovery. Visit the CFDE Highlights page for the latest CFDE research highlights.

Working with Data in the Cloud

Solutions for working with data in the cloud—exploring new ways to combine data sets and discover solutions for working across independent cloud-based platforms. Visit the CFDE Highlights page for the latest CFDE research highlights.

The Common Fund Data Ecosystem (CFDE) is enhancing the ability to ask scientific questions across data sets. Visit the CFDE Portal to learn more.

CFDE Coordinating Center Award: OD025459

Future Eligible Data Coordinating Centers

In January 2020, the Common Fund released an Engagement Opportunity Announcement (OTA-20-005) for eligible DCCs to engage with the CFDE Coordinating Center and other DCCs to establish the CFDE. For more details, please view the Engagement Opportunity Announcement and Process for Rolling Submission of Engagement Opportunity Award Plans.