Disclaimer: The information in these pages are meant to provide general guidance. Instructions and procedures outlined in the Funding Opportunity Announcement and SF424 (R&R) Application Guide take precedence over any information provided and should be referred to for complete and comprehensive directions.

Application Process


Follow the Instructions

It is critical that applicants follow the Research Instructions in the SF424 (R&R) Application Guide except where instructed in the Funding Opportunity Announcement to do otherwise. When the Funding Opportunity Announcement provides instructions that differ from the SF424 (R&R) Application Guide, the instructions given in the Funding Opportunity Announcement take precedence and should be followed.

All attachments should be formatted according to NIH format standards.

Adherence to the application requirements is mandatory and strictly enforced. Applications that are out of compliance with these instructions may not be accepted for review.

Required Forms

Refer to the Funding Opportunity Announcement and SF424 (R&R) Application Guide for complete instructions.

SF424 (R&R) Form

Follow all instructions in the SF424 (R&R) Application Guide.

Agency Routing Identifier

Enter Science Area Designations in the Agency Routing Identifier. Designate two scientific areas (a primary and secondary) from the list below. For each area, enter the one-digit code and abbreviation (e.g., 1 BSS).

1 BSS - Behavioral and Social Science
2 CB - Chemical Biology
3 CTR - Clinical and Translational Research
4 IDI - Infectious Diseases and Immunology
5 IE - Instrumentation and Engineering
6 MCB - Molecular and Cellular Biology
7 NS - Neuroscience
8 HIB - High-Throughput and Integrative Biology
9 BCB - Bioinformatics and Computational Biology

Important: For each of the two science area designations, enter the one-digit code followed by one space and then the corresponding abbreviation. Enter the primary area first and secondary area second. Separate the two entries by a semicolon.

Correct Example: 1 BSS; 7 NS

The areas of science listed above are very broad and frequently overlapping. Pioneer Award reviewers are chosen for their breadth of knowledge and expertise and will be able to review a broad range of applications. Choose the two science areas that are most appropriate for your proposed project.

The scientific areas are used solely to aid in the assignment of panel reviewers and does not affect an application’s funding potential. Application requirements and instructions are identical for all the science areas. All applications are reviewed at the same time, by the same panel, and compete for a single source of dedicated funds.

Note: The science area designations (two one-digit codes with abbreviations) must also be included at the beginning of the Research Strategy essay.

Type of Application

Must be "New."

Proposed Project

The start date should be September 30, 2023, and the end date should be July 31, 2028.

Estimated Project Funding
  • Total Federal Funds Requested: Enter $3,500,000.
  • Total Non-Federal Funds: Enter $0.
  • Total Federal & Non-Federal Funds: Enter $3,500,000.
  • Estimated Program Income: Enter $0.

Note: The budget request is entered only in the fields for "Total Federal Funds Requested" and "Total Federal & Non-Federal Funds" as described above. Funds may be requested for personnel (including collaborators), supplies, equipment, sub-contracts, and other allowable costs. Only the five-year direct cost total ($3.5 million) should be entered in the fields for "Total Federal Funds Requested" and "Total Federal & Non-Federal Funds." Applicable Facilities and Administrative (F&A) costs will be determined at the time of award and should not be included in the budget request. A detailed budget is not requested and will not be accepted.

Cover Letter Attachment

The Cover Letter Attachment must include the names of those writing reference letters for the PD/PI and any known project personnel and/or collaborators. The cover letter is for internal NIH use only and will not be shared with peer reviewers. It is used by NIH staff to plan the review and avoid conflicts of interest.

PHS 398 Cover Page Supplement Form

Follow all instructions in the SF424 (R&R) Application Guide.

R&R Other Project Information Form

Follow all instructions in the SF424 (R&R) Application Guide with additional instructions for the sections outlined in the Funding Opportunity Announcement below.

Project Summary/Abstract

There is a limit of 30 lines of text.

Project Narrative

There is a limit of three sentences.

Bibliography & References Cited

Do not use this section. Reference citations are not required. Citations considered essential may be included in the essay and must be included in the page limit.

Facilities & Other Resources

Upload a brief statement (one page maximum) of the facilities to be used for the conduct of the research.


Do not use.

Other Attachments

Do not use.

Other Tips
  • For more help on human subjects, visit the NIH Grants & Funding website.
  • Foreign components are defined as the performance of any significant scientific element or segment of a project outside of the United States, either by the recipient or by a researcher employed by a foreign organization, whether or not grant funds are expended. It is crucial that you disclose all foreign components, which include foreign collaborations that will result in co-authorship. See the definition of Foreign Components for more details.

Project/Performance Site Location(s)

Follow all instructions in the SF424 (R&R) Application Guide.

R&R Senior/Key Person Profile Form

Follow all instructions in the SF424 (R&R) Application Guide, but only the PD/PI’s biosketch is allowed. Inclusion of other personnel or collaborator biosketches anywhere in the application will result in your application being administratively withdrawn.

Profile Project Director/Principal Investigator

Attach a list of Current and Pending Support from all sources, including current year direct costs and effort devoted to each project.

Profile - Senior/Key Person

Do not use. Submit information for the PD/PI only. Information on collaborators and other key personnel is not required but may be included in the Research Strategy essay.

Additional Senior/Key Person Profile(s)

Do not use. Only the PD/PI may submit a Biographical Sketch. Inclusion of other personnel or collaborator biosketches anywhere in the application will result in your application being administratively withdrawn.

R&R Budget Form

Do not use. A detailed budget is not requested and will not be accepted.

R&R Subaward Budget

Do not use. A detailed budget is not requested and will not be accepted.

PHS 398 Research Plan Form

Follow all instructions in the SF424 (R&R) Application Guide with additional instructions in the Funding Opportunity Announcement.

Specific Aims

Do not use.

Research Strategy

The Research Strategy essay should contain the information below and be saved as a pdf titled "Essay.pdf."

Your essay should describe:

  1. Your innovative vision for addressing a major challenge or pursuing an outstanding opportunity of relevance to NIH
  2. The importance of this challenge or opportunity
  3. Your qualifications to engage in groundbreaking research

No detailed scientific plan should be provided since the research plan is expected to evolve during the tenure of the grant. The essay should include the following sections in the order given with the headings as shown below:

  1. Scientific Areas: Provide 1-digit code and abbreviation for primary and secondary science areas at the beginning of essay. See "Agency Routing Identifier" information above for codes and format.
  2. Project Title: The project title must be descriptive of the proposed project.
  3. Project Description: Prominently indicate that neither a detailed experimental plan nor extensive preliminary data are being provided per the FOA. However, the reviewers must still have a clear sense of the overall research to be pursued and must be convinced that the research will be pursued in a robust and rigorous manner. The writing should be at a level that conveys the significance and impact of the application to broadly knowledgeable scientists with different expertise domains.
    • What is the scientific challenge or opportunity that will be addressed, and why is this important?
    • What are the pioneering, highly innovative approaches that, if successful, would lead to groundbreaking or paradigm-shifting results?
  4. Evidence of PD's/PI's Innovativeness: What concrete evidence can you provide for your claim of innovativeness? For example, qualities common to many highly innovative people include the ability to integrate diverse sources of information; an inclination to question paradigms; a willingness to work with intellectual uncertainties; persistence in the face of failure; an ability to work collaboratively with researchers from diverse disciplines; and the energy and concentration necessary to plan and execute effective strategies for accomplishing goals.
  5. How the Planned Research Differs from the PD's/PI's Past or Current Work: How does the proposed project represent a new and distinct direction for your research? While a new research direction may have the PDF/PI's prior work and expertise as its foundation, it cannot be an obvious extension or scale-up of a current research enterprise which could be appropriate for a more conventional NIH funding mechanism, such as a new or renewal R01. Rather, a new research direction must reflect a fundamental new insight and which may involve the development of exceptionally innovative approaches and/or the posing of radically unconventional hypotheses. Applications for projects that are extensions of ongoing research should not be submitted.
  6. Suitability for Pioneer Award Program: Why is the planned research uniquely suited to the stated goal of the Pioneer Award rather than a more “traditional” grant mechanism?
  7. Statement of Research Effort Commitment: A statement must be included that, if chosen to receive an award, the PD/PI will commit more than 6 person-months (at least 51%) of his/her research effort to the project supported by the Pioneer Award in the first three years of the award and at least 4 months (33%) research effort and at least 3 months (25%) in years four and five, respectively. Applicants with current research commitments of 6 person-months or more must provide a compelling explanation describing how their effort on existing grants will be adjusted to permit them to devote the required minimum effort to the Pioneer Award project

Applicants considering research involving clinical trials are strongly advised to discuss their research ideas with IC staff at the scientifically most relevant NIH Institutes or Centers (ICs) to ensure that such research would conform to the clinical trial research policies of those ICs. Funding of applications involving clinical trials is contingent upon conformance to the policies of the IC administering the award.

Note: References are not required but if included must fit within the page limit. Figures and illustrations may be included but must also fit within the page limit. Letters of collaboration will not be accepted. Information on collaborators may be included in the Essay and their names and affiliations should be listed in the PHS Assignment Request Form (see below).

Progress Report Publication List

Do not use.

Multiple PD/PI Leadership Plan

Do not use.

Consortium/Contractual Arrangements

Do not use.

Letters of Support

Do not use.

Resource Sharing Plan

You are expected to comply with instructions for Resource Sharing Plans in the SF424 (R&R) Application Guide, but the plans will be asked for as Just in Time information if an award is being considered.


Only limited Appendix materials are allowed as described in the SF424 (R&R) Application Guide.

PHS Human Subjects and Clinical Trials Information

Follow the instructions in the SF424 (R&R) Application Guide. But if you answered "Yes" to the question “Are Human Subjects Involved?” on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.

Study Record: PHS Human Subjects and Clinical Trials Information

Follow the instructions in the SF424 (R&R) Application Guide.

Delayed Onset Study

Follow the instructions in the SF424 (R&R) Application Guide. Note: Delayed onset does not apply to a study that can be described but will not start immediately (i.e., delayed start).

PHS Assignment Request Form

Follow all instructions in the SF424 (R&R) Application Guide, but do not request an assignment to a particular review panel (integrated review group) or awarding component (NIH Institute or Center). All applications are automatically received as "Office of the Director" applications and reviewed by a single Special Emphasis Panel convened by the Center for Scientific Review.

Provide the names of collaborators and their institutional affiliations so the Scientific Review Officer can avoid conflicts of interest when selecting reviewers. Also, if you wish to exclude individuals from reviewing your application, list their names, institutional affiliations, and the reasons why they should not serve as reviewers. NIH will consider your request but is not obligated to accept it.



More questions? Contact us at PioneerAwards@mail.nih.gov.

This page last reviewed on August 22, 2022