Frequently Asked Questions

NIH Common Fund Cryoelectron Tomography Initiative

RFA-RM-19-009 (Service Centers)

RFA-RM-19-010 (Service Network Hub)

Purpose

1.  What is the purpose of these RFAs?

2.  Will the awards be research project grants?

3.  How will these cooperative agreements differ from a research grant?

4.  Are there other significant differences?

5.  Where do I find the special terms governing the conduct of awards made under these RFAs?

6.  Will this initiative be continued after the first project period?

7.  Post award, what outcomes will be assessed in evaluating progress?

8.  Will publications by the centers be a consideration in evaluating progress or in the continuation of the program?

RFAs

1.  How are the network hub (RFA-RM-19-010) and the specimen preparation centers (RFA-RM-19-009) alike?

2.  How are the network hub (RFA-RM-19-010) and the other service centers (RFA-RM-19-009) different?

Applications

1.  Can I submit more than one application to the same RFA?

2.  Can I apply to both RFA-RM-19-010 and RFA-RM-19-009?

3.  Can I apply as a PD/PI on one team applying to RFA-RM-19-010, and also as a PD/PI(s) on a different team applying to RFA-RM-19-009?

4.  What is the page limit for the Research Strategy section of the application?

5.  What PI effort is required?

6.  I have scientific expertise but do not have prior experience running an NIH center or collaborative grant. Should I consider applying to RFA-RM-19-009 (Service Centers for specimen preparation)?

7.  I have scientific expertise but do not have prior experience running an NIH center or collaborative grant. Should I consider applying to RFA-RM-19-010 (Network Hub)?

8.  I am a relatively new investigator still in the first project period of my NIH grant. Should I consider applying?

9.  The RFAs look very similar. Do I need to read both of them?

Services

1.  What is a "standard service"?

2.  What is "cross-training"?

3.  What is "access to instrumentation"?

4.  What standard services should I include in my application?

5.  What capacity (throughput) of services should I propose (i.e. how much time to prepare a particular kind of specimen)?

6.  How do I judge what is realistic?

7.  After I receive my award, what minimum specimen preparation services will my center be expected to provide?

8.  Beyond the minimum specimen preparation services, will all the centers be expected to provide the same services?

9.  The RFAs look very similar. Do I need to read both of them?

10.  Should I include real examples of users and their projects?

11.  Beyond standard services (specimen preparation for RFA-RM-19-009; specimen collection and data collection for RFA-RM-19-010), we would like to provide assistance and training to users with other aspects of their projects. Should we include plans to use project funds to offer these additional services?

12.  We have a cryoelectron microscope on site, and in our application for a specimen preparation center (RFA-RM-19-009) we would like to include data collection services. Should we include plans to use project funds to offer this additional service?

13.  Our laboratory has expertise in advanced computational methods for extracting information from cryoET maps. In our application for the network hub (RFA-RM-19-010) we would like to include services like sub-tomogram averaging, segmentation, and machine learning. Should we include plans to use project funds to offer this additional service?

Technology Development

1.  Will the centers perform technology development?

2.  Are the centers expected to invent entirely new technologies?

3.  What is "internal development"?

4.  Should I include plans for internal development?

5.  What is "development of a protocol"?

6.  We would like to explore the feasibility of entirely new technologies for cryoET, can we include this?

7.  If my interest is technology development rather than service, what are my funding options?

8.  I have research projects in my laboratory that are relevant to the center. Should I integrate them into my application?

Users and Staff

1.  What does it mean that "services and cross-training should be provided and tracked on a parent laboratory basis?"

2.  Can my center offer training directly to individuals?

3.  How can individuals find training in the cryoET field?

4.  Who is an "approved user"?

5.  Can I host long-term visitors (for example, sabbatical visitors or postdoctoral fellows?

6.  Can I offer workshops and courses?

7.  Will I be able to use my center's resources for my other research?

8.  Should I recruit postdoctoral fellows to fill the technical service roles?

Individual Centers and the Network

1.  Will the network hub lead the network or provide directions to the other centers?

2.  In my application, should I address technical and scientific criteria for evaluating users' applications for services?

3.  In my application, should I include plans for the administration and logistics of the Network Coordinating Group and the user review process?

4.  How will users be assigned to the individual centers?

Budget, General

1.  Do the centers pay for users' travel, lodging or board?

2.  Do the centers pay for users' specialty supplies or other expenses?

3.  Can I include a foreign subcontract in my application?

4.  Can I engage a foreign investigator from outside the US as a consultant?

5.  Are service contracts allowed?

6.  Is carry-over allowable?

7.  Should I discuss carry-over in my application?

8.  How should I handle vertebrate animals and human subjects?

Interim Review

1.  What is the interim review?

This page last reviewed on August 5, 2019