Molecular Libraries and Imaging (2499)
Publication TitleAuthorsJournalPublication DatePage NoPubMedID
A Novel Inhibitor of Alpha- Galactosidase Identified from a Compound Library ScreenMotabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng WCurrent Chemical Genomics20104: 67-73999999929
Fluorescence polarization assays in small molecule screeningLea, W. L., and Simeonov, A. Expert Op Drug Disc 20116: 17-32999999928
The Ups and Downs of Structure-Activity LandscapesGuha R. Methods Mol Biol.2011672:101-107999999927
The Ups and Downs of Structure-Activity LandscapesGuha R.Cheminformatics and Computational Chemical Biology2011101-107999999926
Understanding Enzymes as Reporters or Targets in Assays Using Quantitative High-Throughput Screening (qHTS)Auld DS, Thorne N, Boxer MB, Southall N, Shen M, Thomas CJ, Inglese J4th International ESCEC Symposium on Experimental Standard Conditions of Enzyme Characterizations2010999999925
Identification and validation of clinically utilized drugs for the treatment of adrenocortical cancerNilubol N, Zhang L, Shen M, Zhang Y-Q, He M, Kebebew EEndocrine-Related Cancer2012999999924
Interplay between Tdp1, CtIP and PARP for the Repair of Topoisomerase I and II-induced DNA Damage in Vertebrate CellsMurai J, Huang S-Y N, Das BB, Dexheimer TS, Takeda S, Pommier YPloS Genetics2012999999923
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinaseMorgan HP, Walsh M, Boxer M, Shen M, Blackburn EA, Wear MA, McNae IW, Nowicki MW, Michels P A-M, Auld DS, Fothergill-Gilmore LA & Walkinshaw MDJ. Biological Chemistry2012999999922
NRG1-ErbB4-p110δ signaling in schizophrenia. Reversal of amphetamine-induced behaviors by selective p110δ inhibitionLaw AJ, Wang Y, Sei Y, Papaleo F, Huang W, Thomas CJ, Austin CP, Harrison PJ, Lipska BK, Hyde TM, Kleinman JE, Weinberger DRProc Natl Acad Sci USA2012999999921
Physiopathological role of the Neuropeptide S system in cocaine relapse: A mechanism mediated by the hypothalamic hypocretin systemKallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo RProc Natl Acad Sci USA2010999999920
Computational approaches in cheminformatics and bioinformaticsGuha R, Bender A. 1st ed Hoboken2012999999919
Exploring Structure-activity-relationships to design novel drugsGuha, R.Silico Models for Drug Discovery2012999999918
Selecting, acquiring and using small molecule libraries for high-throughput screeningDandapani S, Rosse G, Southall N, Salvino JM, Thomas CJCurr. Prot. Chem. Biol.2012999999917
A High Affinity αIIbβ3 Antagonist Displays a Novel Mechanism of Inhibiting Ligand Binding, Competing with Mg2+ for Interacting with the MIDAS Glu220Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Zhu J, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BSNat. Struct. Mol. Biol.2011999999916
Molecular Sensors for Transcriptional and Post-Transcriptional AssaysAuld DS & Thorne NChemical Genomics2011999999915
Urotensin-II Receptor Antagonists: From Peptides to Small-Molecules. Assessment of Potency, Selectivity, and In Vitro ADME PropertiesLuci D, Maloney DDiane Luci: ACS 2011999999914
Chapter 16. Tyrosyl DNA-phosphodiesteraseDexheimer TS, Huang S-YN, Das BB, Pommier YDNA Topoisomerases and Cancer. Cancer Drug Discovery and Development2012335-354999999913
Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New Bioactive CompoundsBenson SC, Lee L, Wei W, Ni F, Olmos JDJ, Strom KR, Beeler AB, Cheng KC-C, Inglese J, Kota S, Takahashi V, Strosberg AD, Connor JH, Bushkin GG, Snyder JKHeterocycles201184 (1)999999912
On Exploring Structure Activity RelationshipsGuha RSilico Models for Drug Discovery2013999999911
Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in RatsWang M, Defranco D, Wright K, Quazi S, Chen J, Spencer-Pierce J, Zaghloul I, Pak R, Darvari R, Krishnan A, Perreault M, Sun L, Ozer J, O’Hara D, Rup B, and Xu XJ Bioequiv Availab 2012069-077999999910
Perspectives and Challenges in Epigenetic Therapy: DNA Methylation in Cancer Stem Cells. Book Chapter in: DNA Methylation: Principles, Mechanisms and ChallengesSun L, Yang A, Cabarcas SM, Mathews LA, Farrar WNova Science Publisher2013999999909
Pharmaceutical Profiling Case Study in DisruptionKerns, EH. ACS Med Chem Lett2013150-152999999908
CD28-ITK signals regulate autoreactive T cell trafficking into tissuesJain M, Jiang J-k, Greiner D, Thomas CJ, Berg LJ, Kang JThe Journal of Immunology2012188, 123.41999999907
Identification of Potent and Selective Diphenylpropanamide RORγ InhibitorsHuh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP Johnson RL, Huang W Littman DRACS Med Chem Lett.201279-84999999906
Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data SourcesGuha R, Nguyen D-T, Southall N, Jadhav ACurrent Protocols in Chemical Biology2012193–209999999905
Exploring Structure-Activity Data Using the Landscape ParadigmGuhaWIREs Comput Mol Sci, 22012829–841999999904
Reply to Kojo: Mechanisms of antioxidant-induced DNA damageFox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung KProc Natl Acad Sci USA2012109 (30)999999903
Selecting, acquiring and using small molecule libraries for high-throughput screeningDandapani S, Rosse G, Southall N, Salvino JM, Thomas CJCurrent Protocols in Chemical Biology2012177–191999999902
Toxicity testing with Heparg spheroidsAuld DS, Lea W, Davis MI, Simeonov AASSAY and Drug Development Technologies2012393-406999999901
Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease.Guo, Yiqing; Pace, Jesse; Li, Zhengzhe; Ma'ayan, Avi; Wang, Zichen; Revelo, Monica P; Chen, Edward; Gu, Xiangchen; Attalah, Ahmed; Yang, Yaqi; Estrada, Chelsea; Yang, Vincent W; He, John C; Mallipattu, Sandeep KJournal of the American Society of Nephrology : JASN.2018 Aug 24;30143559
eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks.Clarke, Daniel J B; Kuleshov, Maxim V; Schilder, Brian M; Torre, Denis; Duffy, Mary E; Keenan, Alexandra B; Lachmann, Alexander; Feldmann, Axel S; Gundersen, Gregory W; Silverstein, Moshe C; Wang, Zichen; Ma'ayan, AviNucleic acids research.2018 Jul 02;29800326
A proteomics landscape of circadian clock in mouse liver.Wang, Yunzhi; Song, Lei; Liu, Mingwei; Ge, Rui; Zhou, Quan; Liu, Wanlin; Li, Ruiyang; Qie, Jingbo; Zhen, Bei; Wang, Yi; He, Fuchu; Qin, Jun; Ding, ChenNature communications.2018 Apr 19;29674717
Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer.Collins, Kyla A L; Stuhlmiller, Timothy J; Zawistowski, Jon S; East, Michael P; Pham, Trang T; Hall, Claire R; Goulet, Daniel R; Bevill, Samantha M; Angus, Steven P; Velarde, Sara H; Sciaky, Noah; Oprea, Tudor I; Graves, Lee M; Johnson, Gary L; Gomez, Shawn MOncotarget.2018 Mar 20;29643987
Massive mining of publicly available RNA-seq data from human and mouse.Lachmann, Alexander; Torre, Denis; Keenan, Alexandra B; Jagodnik, Kathleen M; Lee, Hoyjin J; Wang, Lily; Silverstein, Moshe C; Ma'ayan, AviNature communications.;29636450
Datasets2Tools, repository and search engine for bioinformatics datasets, tools and canned analyses.Torre, Denis; Krawczuk, Patrycja; Jagodnik, Kathleen M; Lachmann, Alexander; Wang, Zichen; Wang, Lily; Kuleshov, Maxim V; Ma'ayan, AviScientific data.2018 Feb 27;29485625
Unexplored therapeutic opportunities in the human genome.Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren; Campbell, Allen; Gan, Gregory N; Gaulton, Anna; Gomez, Shawn M; Guha, Rajarshi; Hersey, Anne; Holmes, Jayme; Jadhav, Ajit; Jensen, Lars Juhl; Johnson, Gary L; Karlson, Anneli; Leach, Andrew R; Ma'ayan, Avi; Malovannaya, Anna; Mani, Subramani; Mathias, Stephen L; McManus, Michael T; Meehan, Terrence F; von Mering, Christian; Muthas, Daniel; Nguyen, Dac-Trung; Overington, John P; Papadatos, George; Qin, Jun; Reich, Christian; Roth, Bryan L; Schürer, Stephan C; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Tomita, Susumu; Tudose, Ilinca; Ursu, Oleg; Vidovic, Du?ica; Waller, Anna; Westergaard, David; Yang, Jeremy J; Zahoránszky-Köhalmi, GergelyNature reviews. Drug discovery.2018 May;29472638
L1000FWD: fireworks visualization of drug-induced transcriptomic signatures.Wang, Zichen; Lachmann, Alexander; Keenan, Alexandra B; Ma'ayan, AviBioinformatics (Oxford, England).;29420694
Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition.Koplev, Simon; Lin, Katie; Dohlman, Anders B; Ma'ayan, AviPLoS computational biology.2018 01;29293502
Structure-inspired design of ?-arrestin-biased ligands for aminergic GPCRs.McCorvy, John D; Butler, Kyle V; Kelly, Brendan; Rechsteiner, Katie; Karpiak, Joel; Betz, Robin M; Kormos, Bethany L; Shoichet, Brian K; Dror, Ron O; Jin, Jian; Roth, Bryan LNature chemical biology.2017 Dec 11;29227473
Cell-specific prediction and application of drug-induced gene expression profiles.Hodos, Rachel; Zhang, Ping; Lee, Hao-Chih; Duan, Qiaonan; Wang, Zichen; Clark, Neil R; Ma'ayan, Avi; Wang, Fei; Kidd, Brian; Hu, Jianying; Sontag, David; Dudley, JoelPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.2018;29218867
Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age.Wang, Zichen; Li, Li; Glicksberg, Benjamin S; Israel, Ariel; Dudley, Joel T; Ma'ayan, AviJournal of biomedical informatics.2017 Dec;29113935
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.Niepel, Mario; Hafner, Marc; Duan, Qiaonan; Wang, Zichen; Paull, Evan O; Chung, Mirra; Lu, Xiaodong; Stuart, Joshua M; Golub, Todd R; Subramanian, Aravind; Ma'ayan, Avi; Sorger, Peter KNature communications.2017 Oct 30;29084964
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin?G Associated Kinase.Asquith, Christopher R M; Laitinen, Tuomo; Bennett, James M; Godoi, Paulo H; East, Michael P; Tizzard, Graham J; Graves, Lee M; Johnson, Gary L; Dornsife, Ronna E; Wells, Carrow I; Elkins, Jonathan M; Willson, Timothy M; Zuercher, William JChemMedChem.2018 Jan 08;29072804
D4dopamine receptor high-resolution structures enable the discovery of selective agonists.Wang, Sheng; Wacker, Daniel; Levit, Anat; Che, Tao; Betz, Robin M; McCorvy, John D; Venkatakrishnan, A J; Huang, Xi-Ping; Dror, Ron O; Shoichet, Brian K; Roth, Bryan LScience (New York, N.Y.).2017 10 20;29051383
Discovery of new GPCR ligands to illuminate new biology.Roth, Bryan L; Irwin, John J; Shoichet, Brian KNature chemical biology.2017 Nov;29045379
Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.Pera, Tonio; Deshpande, Deepak A; Ippolito, Michael; Wang, Bin; Gavrila, Adelina; Michael, James V; Nayak, Ajay P; Tompkins, Eric; Farrell, Eleni; Kroeze, Wesley K; Roth, Bryan L; Panettieri Jr, Reynold A; Benovic, Jeffrey L; An, Steven S; Dulin, Nickolai O; Penn, Raymond BFASEB journal : official publication of the Federation of American Societies for Experimental Biology.;29042451
Report and Application of a Tool Compound Data Set.Butler, Kyle V; MacDonald, Ian A; Hathaway, Nathaniel A; Jin, JianJournal of chemical information and modeling.2017 Nov 02;29035535
Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data.Fernandez, Nicolas F; Gundersen, Gregory W; Rahman, Adeeb; Grimes, Mark L; Rikova, Klarisa; Hornbeck, Peter; Ma'ayan, AviScientific data.2017 Oct 10;28994825
Complex systems biology.Ma'ayan, AviJournal of the Royal Society, Interface.2017 Sep;28931638
A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.Lam, Pui-Ying; Mendu, Suresh K; Mills, Robert W; Zheng, Baohui; Padilla, Hugo; Milan, David J; Desai, Bimal N; Peterson, Randall TScientific reports.2017 Sep 19;28928472
Assembly rules for GABAA receptor complexes in the brain.Martenson, James S;Yamasaki, Tokiwa;Chaudhury, Nashid H;Albrecht, David;Tomita, SusumueLife28816653
Intracoronary Imaging, Cholesterol Efflux, and Transcriptomics after Intensive Statin Treatment in Diabetes.Chamaria, Surbhi; Johnson, Kipp W; Vengrenyuk, Yuliya; Baber, Usman; Shameer, Khader; Divaraniya, Aparna A; Glicksberg, Benjamin S; Li, Li; Bhatheja, Samit; Moreno, Pedro; Maehara, Akiko; Mehran, Roxana; Dudley, Joel T; Narula, Jagat; Sharma, Samin K; Kini, Annapoorna SScientific reports.2017 Aug 01;28765529
How Ligands Illuminate GPCR Molecular Pharmacology.Wacker, Daniel; Stevens, Raymond C; Roth, Bryan LCell.2017 Jul 27;28753422
From flamingo dance to (desirable) drug discovery: a nature-inspired approach.Sánchez-Rodríguez, Aminael; Pérez-Castillo, Yunierkis; Schürer, Stephan C; Nicolotti, Orazio; Mangiatordi, Giuseppe Felice; Borges, Fernanda; Cordeiro, M Natalia D S; Tejera, Eduardo; Medina-Franco, José L; Cruz-Monteagudo, MaykelDrug discovery today.2017 Jun 15;28624633
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.Sangodkar, Jaya; Perl, Abbey; Tohme, Rita; Kiselar, Janna; Kastrinsky, David B; Zaware, Nilesh; Izadmehr, Sudeh; Mazhar, Sahar; Wiredja, Danica D; O'Connor, Caitlin M; Hoon, Divya; Dhawan, Neil S; Schlatzer, Daniela; Yao, Shen; Leonard, Daniel; Borczuk, AThe Journal of clinical investigation.2017 Jun 01;28504649
A mouse tissue transcription factor atlas.Zhou, Quan; Liu, Mingwei; Xia, Xia; Gong, Tongqing; Feng, Jinwen; Liu, Wanlin; Liu, Yang; Zhen, Bei; Wang, Yi; Ding, Chen; Qin, JunNature communications.2017 Apr 21;28429721
L1000CDS(2): LINCS L1000 characteristic direction signatures search engine.Duan, Qiaonan; Reid, St Patrick; Clark, Neil R; Wang, Zichen; Fernandez, Nicolas F; Rouillard, Andrew D; Readhead, Ben; Tritsch, Sarah R; Hodos, Rachel; Hafner, Marc; Niepel, Mario; Sorger, Peter K; Dudley, Joel T; Bavari, Sina; Panchal, Rekha G; Ma'ayan, AviNPJ systems biology and applications.2016;28413689
In silico design of novel probes for the atypical opioid receptor MRGPRX2.Lansu, Katherine; Karpiak, Joel; Liu, Jing; Huang, Xi-Ping; McCorvy, John D; Kroeze, Wesley K; Che, Tao; Nagase, Hiroshi; Carroll, Frank I; Jin, Jian; Shoichet, Brian K; Roth, Bryan LNature chemical biology.2017 May;28288109
GARLH Family Proteins Stabilize GABAA Receptors at Synapses.Yamasaki, Tokiwa; Hoyos-Ramirez, Erika; Martenson, James S; Morimoto-Tomita, Megumi; Tomita, SusumuNeuron.2017 Mar 08;28279354
Systemic QSAR and phenotypic virtual screening: chasing butterflies in drug discovery.Cruz-Monteagudo, Maykel; Schürer, Stephan; Tejera, Eduardo; Pérez-Castillo, Yunierkis; Medina-Franco, José L; Sánchez-Rodríguez, Aminael; Borges, FernandaDrug discovery today.2017 Mar 06;28274840
A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.Pappalardo, Zachary; Gambhir Chopra, Deeksha; Hennings, Thomas G; Richards, Hunter; Choe, Justin; Yang, Katherine; Baeyens, Luc; Ang, Kenny; Chen, Steven; Arkin, Michelle; German, Michael S; McManus, Michael T; Ku, Gregory MDiabetes.2017 Jun;28246293
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.Le Gonidec, Sophie; Chaves-Almagro, Carline; Bai, Yushi; Kang, Hye Jin; Smith, Allyson; Wanecq, Estelle; Huang, Xi-Ping; Prats, Hervé; Knibiehler, Bernard; Roth, Bryan L; Barak, Larry S; Caron, Marc G; Valet, Philippe; Audigier, Yves; Masri, BernardFASEB journal : official publication of the Federation of American Societies for Experimental Biology.2017 06;28242772
Differential cytokine contributions of perivascular haematopoietic stem cell niches.Asada, Noboru; Kunisaki, Yuya; Pierce, Halley; Wang, Zichen; Fernandez, Nicolas F; Birbrair, Alexander; Ma'ayan, Avi; Frenette, Paul SNature cell biology.2017 Mar;28218906
Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning.Shameer, Khader; Glicksberg, Benjamin S; Hodos, Rachel; Johnson, Kipp W; Badgeley, Marcus A; Readhead, Ben; Tomlinson, Max S; O'Connor, Timothy; Miotto, Riccardo; Kidd, Brian A; Chen, Rong; Ma'ayan, Avi; Dudley, Joel TBriefings in bioinformatics.2017 Feb 15;28200013
Automated cell type discovery and classification through knowledge transfer.Lee, Hao-Chih; Kosoy, Roman; Becker, Christine E; Dudley, Joel T; Kidd, Brian ABioinformatics (Oxford, England).2017 Jun 01;28158442
Protein biomarker druggability profiling.Mani, Subramani; Cannon, Daniel; Ohls, Robin; Oprea, Tudor; Mathias, Stephen; Ballard, Karri; Ursu, Oleg; Bologa, CristianJournal of biomedical informatics.2017 Feb;28131723
Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity.Smith, Milo R; Burman, Poromendro; Sadahiro, Masato; Kidd, Brian A; Dudley, Joel T; Morishita, HirofumieNeuro.2016 Nov-Dec;28101530
Novel Therapeutics Identification for Fibrosis in Renal Allograft Using Integrative Informatics Approach.Li, Li; Greene, Ilana; Readhead, Benjamin; Menon, Madhav C; Kidd, Brian A; Uzilov, Andrew V; Wei, Chengguo; Philippe, Nimrod; Schroppel, Bernd; He, John Cijiang; Chen, Rong; Dudley, Joel T; Murphy, BarbaraScientific reports.2017 Jan 04;28051114
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven FinkbeinerProceedings of the National Academy of Sciences of the United States of America.2017 Jan 31;1165–117028028237
Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis.Wei, Chengguo; Li, Li; Menon, Madhav C; Zhang, Weijia; Fu, Jia; Kidd, Brian; Keung, Karen L; Woytovich, Christopher; Greene, Ilana; Xiao, Wenzhen; Salem, Fadi; Yi, Zhengzi; He, John Cijiang; Dudley, Joel T; Murphy, BarbaraJournal of the American Society of Nephrology : JASN.2017 May;27927780
A comprehensive map of molecular drug targets.Santos, Rita; Ursu, Oleg; Gaulton, Anna; Bento, A Patrícia; Donadi, Ramesh S; Bologa, Cristian G; Karlsson, Anneli; Al-Lazikani, Bissan; Hersey, Anne; Oprea, Tudor I; Overington, John PNature reviews. Drug discovery.2017 01;27910877
Pharos: Collating protein information to shed light on the druggable genome.Nguyen, Dac-Trung; Mathias, Stephen; Bologa, Cristian; Brunak, Soren; Fernandez, Nicolas; Gaulton, Anna; Hersey, Anne; Holmes, Jayme; Jensen, Lars Juhl; Karlsson, Anneli; Liu, Guixia; Ma'ayan, Avi; Mandava, Geetha; Mani, Subramani; Mehta, Saurabh; Overington, John; Patel, Juhee; Rouillard, Andrew D; Schürer, Stephan; Sheils, Timothy; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Yang, Jeremy; Jadhav, Ajit; Oprea, Tudor I; Guha, RajarshiNucleic acids research.2017 Jan 4;27903890
EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS.Cohain, Ariella; Divaraniya, Aparna A; Zhu, Kuixi; Scarpa, Joseph R; Kasarskis, Andrew; Zhu, Jun; Chang, Rui; Dudley, Joel T; Schadt, Eric EPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.2016;27896968
EXPLORING BRAIN TRANSCRIPTOMIC PATTERNS: A TOPOLOGICAL ANALYSIS USING SPATIAL EXPRESSION NETWORKS.Kuncheva, Zhana; Krishnan, Michelle L; Montana, GiovanniPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.2016;27896963
GEN3VA: aggregation and analysis of gene expression signatures from related studies.Gundersen, Gregory W; Jagodnik, Kathleen M; Woodland, Holly; Fernandez, Nicholas F; Sani, Kevin; Dohlman, Anders B; Ung, Peter Man-Un; Monteiro, Caroline D; Schlessinger, Avner; Ma'ayan, AviBMC bioinformatics.2016 Nov 15;27846806
DrugCentral: online drug compendium.Ursu, Oleg; Holmes, Jayme; Knockel, Jeffrey; Bologa, Cristian G; Yang, Jeremy J; Mathias, Stephen L; Nelson, Stuart J; Oprea, Tudor INucleic acids research.2017 Jan 4;27789690
Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.Sato, Seiji; Huang, Xi-Ping; Kroeze, Wesley K; Roth, Bryan LMolecular pharmacology.2016 Dec;27754899
Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.Wang, Zichen; Monteiro, Caroline D; Jagodnik, Kathleen M; Fernandez, Nicolas F; Gundersen, Gregory W; Rouillard, Andrew D; Jenkins, Sherry L; Feldmann, Axel S; Hu, Kevin S; McDermott, Michael G; Duan, Qiaonan; Clark, Neil R; Jones, Matthew R; Kou, Yan; Goff, Troy; Woodland, Holly; Amaral, Fabio M R; Szeto, Gregory L; Fuchs, Oliver; Schüssler-Fiorenza Rose, Sophia M; Sharma, Shvetank; Schwartz, Uwe; Bausela, Xabier Bengoetxea; Szymkiewicz, Maciej; Maroulis, Vasileios; Salykin, Anton; Barra, Carolina M; Kruth, Candice D; Bongio, Nicholas J; Mathur, Vaibhav; Todoric, Radmila D; Rubin, Udi E; Malatras, Apostolos; Fulp, Carl T; Galindo, John A; Motiejunaite, Ruta; Jüschke, Christoph; Dishuck, Philip C; Lahl, Katharina; Jafari, Mohieddin; Aibar, Sara; Zaravinos, Apostolos; Steenhuizen, Linda H; Allison, Lindsey R; Gamallo, Pablo; de Andres Segura, Fernando; Dae Devlin, Tyler; Pérez-García, Vicente; Ma'ayan, AviNature communications.2016 Sep 26;27667448
Replicating Cardiovascular Condition-Birth Month Associations.Li, Li; Boland, Mary Regina; Miotto, Riccardo; Tatonetti, Nicholas P; Dudley, Joel TScientific reports.2016 Sep 14;27624541
An open RNA-Seq data analysis pipeline tutorial with an example of reprocessing data from a recent Zika virus study.Wang, Zichen; Ma'ayan, AviF1000Research.2016 Jul 5;27583132
Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.Butler, Kyle V; Bohn, Kelsey; Hrycyna, Christine A; Jin, JianMedChemComm.2016 May 1;27547295
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.von Schimmelmann, Melanie; Feinberg, Philip A; Sullivan, Josefa M; Ku, Stacy M; Badimon, Ana; Duff, Mary Kaye; Wang, Zichen; Lachmann, Alexander; Dewell, Scott; Ma'ayan, Avi; Han, Ming-Hu; Tarakhovsky, Alexander; Schaefer, AnneNature neuroscience.2016 Oct;27526204
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins.Rouillard, Andrew D; Gundersen, Gregory W; Fernandez, Nicolas F; Wang, Zichen; Monteiro, Caroline D; McDermott, Michael G; Ma'ayan, AviDatabase : the journal of biological databases and curation.2016;27374120
Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.Glicksberg, Benjamin S; Li, Li; Badgeley, Marcus A; Shameer, Khader; Kosoy, Roman; Beckmann, Noam D; Pho, Nam; Hakenberg, Jörg; Ma, Meng; Ayers, Kristin L; Hoffman, Gabriel E; Dan Li, Shuyu; Schadt, Eric E; Patel, Chirag J; Chen, Rong; Dudley, Joel TBioinformatics (Oxford, England).2016 Jun 15;27307606
Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers.Mallipattu, Sandeep K; Guo, Yiqing; Revelo, Monica P; Roa-Peña, Lucia; Miller, Timothy; Ling, Jason; Shankland, Stuart J; Bialkowska, Agnieszka B; Ly, Victoria; Estrada, Chelsea; Jain, Mukesh K; Lu, Yuan; Ma'ayan, Avi; Mehrotra, Anita; Yacoub, Rabi; Nord, Edward P; Woroniecki, Robert P; Yang, Vincent W; He, John CJournal of the American Society of Nephrology : JASN.2016 Jun 10;27288011
Cognitive Machine-Learning Algorithm for Cardiac Imaging: A Pilot Study for Differentiating Constrictive Pericarditis From Restrictive Cardiomyopathy.Sengupta, Partho P; Huang, Yen-Min; Bansal, Manish; Ashrafi, Ali; Fisher, Matt; Shameer, Khader; Gall, Walt; Dudley, Joel TCirculation. Cardiovascular imaging.2016 Jun;27266599
?1 receptor ligands control a switch between passive and active threat responses.Rennekamp, Andrew J; Huang, Xi-Ping; Wang, You; Patel, Samir; Lorello, Paul J; Cade, Lindsay; Gonzales, Andrew P W; Yeh, Jing-Ruey Joanna; Caldarone, Barbara J; Roth, Bryan L; Kokel, David; Peterson, Randall TNature chemical biology.2016 Jul;27239788
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.Bruni, Giancarlo; Rennekamp, Andrew J; Velenich, Andrea; McCarroll, Matthew; Gendelev, Leo; Fertsch, Ethan; Taylor, Jack; Lakhani, Parth; Lensen, Dennis; Evron, Tama; Lorello, Paul J; Huang, Xi-Ping; Kolczewski, Sabine; Carey, Galen; Caldarone, Barbara J; Prinssen, Eric; Roth, Bryan L; Keiser, Michael J; Peterson, Randall T; Kokel, DavidNature chemical biology.2016 Jul;27239787
Badapple: promiscuity patterns from noisy evidence.Yang, Jeremy J; Ursu, Oleg; Lipinski, Christopher A; Sklar, Larry A; Oprea, Tudor I; Bologa, Cristian GJournal of cheminformatics.2016;27239230
Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.Morgan, David J; Poolman, Toryn M; Williamson, Andrew J K; Wang, Zichen; Clark, Neil R; Ma'ayan, Avi; Whetton, Anthony D; Brass, Andrew; Matthews, Laura C; Ray, David WScientific reports.2016;27226058
Cre dependent DREADD (designer receptors exclusively activated by designer drugs) mice.Zhu, Hu; Aryal, Dipendra K; Olsen, Reid H J; Urban, Daniel J; Swearingen, Amanda; Forbes, Stacy; Roth, Bryan L; Hochgeschwender, UteGenesis (New York, N.Y. : 2000).2016 May 19;27194399
Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records.Miotto, Riccardo; Li, Li; Kidd, Brian A; Dudley, Joel TScientific reports.2016 May 17;27185194
BDDCS, the Rule of 5 and drugability.Benet, Leslie Z; Hosey, Chelsea M; Ursu, Oleg; Oprea, Tudor IAdvanced drug delivery reviews.2016 Jun 1;27182629
Systems Medicine Approaches to Improving Understanding, Treatment, and Clinical Management of Neuroendocrine Prostate Cancer.Yadav, Kamlesh K; Shameer, Khader; Readhead, Ben; Yadav, Shalini S; Li, Li; Kasarskis, Andrew; Tewari, Ashutosh K; Dudley, Joel TCurrent pharmaceutical design.2016;27174811
Drug-induced adverse events prediction with the LINCS L1000 data.Wang, Zichen; Clark, Neil R; Ma'ayan, AviBioinformatics (Oxford, England).2016 Aug 1;27153606
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.Kuleshov, Maxim V; Jones, Matthew R; Rouillard, Andrew D; Fernandez, Nicolas F; Duan, Qiaonan; Wang, Zichen; Koplev, Simon; Jenkins, Sherry L; Jagodnik, Kathleen M; Lachmann, Alexander; McDermott, Michael G; Monteiro, Caroline D; Gundersen, Gregory W; Ma'ayan, AviNucleic acids research.2016 Jul 8;27141961
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Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluationGeorge-Thompson AM, Ursu O, Babkin P, Iancu CV, Whang A, Oprea TI, Choe JYScientific ReportsEpub 2016 Apr 14.27074918
Integrative network modeling approaches to personalized cancer medicineKidd BA, Readhead BP, Eden C, Parekh S, Dudley JTPersonalized Medicine2015 Jun 112(3):245-25727019658
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Evaluation of direct-to-consumer low-volume lab tests in healthy adultsKidd BA, Hoffman G, Zimmerman N, Li L, Morgan JW, Glowe PK, Botwin GJ, Parekh S, Babic N, Doust MW, Stock GB, Schadt EE, Dudley JTJ Clin Invest2016 Mar 28pii: 86318. doi: 10.1172/JCI86318. [Epub ahead of print]27018593
Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles.Rezza, Amélie; Wang, Zichen; Sennett, Rachel; Qiao, Wenlian; Wang, Dongmei; Heitman, Nicholas; Mok, Ka Wai; Clavel, Carlos; Yi, Rui; Zandstra, Peter; Ma'ayan, Avi; Rendl, MichaelCell reports.2016 Mar 29;27009580
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Ruderfer, Douglas M; Charney, Alexander W; Readhead, Ben; Kidd, Brian A; Kähler, Anna K; Kenny, Paul J; Keiser, Michael J; Moran, Jennifer L; Hultman, Christina M; Scott, Stuart A; Sullivan, Patrick F; Purcell, Shaun M; Dudley, Joel T; Sklar, PamelaThe lancet. Psychiatry.2016 Apr;26915512
Translational bioinformatics in the era of real-time biomedical, health care and wellness data streamsShameer K, Badgeley MA, Miotto R, Glicksberg BS, Morgan JW, Dudley JTBrief Bioinform2016 Feb 14pii: bbv118. [Epub ahead of print]26876889
Integrative radiogenomic analysis for multicentric radiophenotype in glioblastomaKong DS, Kim J, Lee IH, Kim ST, Seol HJ, Lee JI, Park WY, Ryu G, Wang Z, Ma'ayan A, Nam DHOncotarget2016 Feb 1doi: 10.18632/oncotarget.7115. [Epub ahead of print]26863628
Principal Angle Enrichment Analysis (PAEA): Dimensionally Reduced Multivariate Gene Set Enrichment Analysis Tool.Clark, Neil R; Szymkiewicz, Maciej; Wang, Zichen; Monteiro, Caroline D; Jones, Matthew R; Ma'ayan, AviProceedings. IEEE International Conference on Bioinformatics and Biomedicine.2015 Nov;256-26226848405
A three-groups model for high-throughput survival screens.Shaby, Benjamin A; Skibinski, Gaia; Ando, Michael; LaDow, Eva S; Finkbeiner, StevenBiometrics.2016 Jan 28;26821783
Fetal liver hematopoietic stem cell niches associate with portal vessels.Khan, Jalal A; Mendelson, Avital; Kunisaki, Yuya; Birbrair, Alexander; Kou, Yan; Arnal-Estapé, Anna; Pinho, Sandra; Ciero, Paul; Nakahara, Fumio; Ma'ayan, Avi; Bergman, Aviv; Merad, Miriam; Frenette, Paul SScience (New York, N.Y.).2016 Jan 8;176-8026634440
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Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(?exon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.Readhead, B; Haure-Mirande, J-V; Zhang, B; Haroutunian, V; Gandy, S; Schadt, E E; Dudley, J T; Ehrlich, M EMolecular psychiatry.2015 Nov 10;26552589
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.Huang, Xi-Ping; Karpiak, Joel; Kroeze, Wesley K; Zhu, Hu; Chen, Xin; Moy, Sheryl S; Saddoris, Kara A; Nikolova, Viktoriya D; Farrell, Martilias S; Wang, Sheng; Mangano, Thomas J; Deshpande, Deepak A; Jiang, Alice; Penn, Raymond B; Jin, Jian; Koller, BeverNature.2015 Nov 26;477-8326550826
Identification of type 2 diabetes subgroups through topological analysis of patient similarity.Li, Li; Cheng, Wei-Yi; Glicksberg, Benjamin S; Gottesman, Omri; Tamler, Ronald; Chen, Rong; Bottinger, Erwin P; Dudley, Joel TScience translational medicine.2015 Oct 28;311ra17426511511
Noribogaine is a G-protein biased ?-opioid receptor agonist.Maillet, Emeline L; Milon, Nicolas; Heghinian, Mari D; Fishback, James; Schürer, Stephan C; Garamszegi, Nandor; Mash, Deborah CNeuropharmacology.2015 Dec;675-8826302653
Reprint of ''Abstraction for data integration: Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction''.Rouillard, Andrew D; Wang, Zichen; Ma'ayan, AviComputational biology and chemistry.2015 Dec;123-3826297300
An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.Sennett, Rachel; Wang, Zichen; Rezza, Amélie; Grisanti, Laura; Roitershtein, Nataly; Sicchio, Cristina; Mok, Ka Wai; Heitman, Nicholas J; Clavel, Carlos; Ma'ayan, Avi; Rendl, MichaelDevelopmental cell.2015 Sep 14;577-9126256211
Computational and Practical Aspects of Drug Repositioning.Oprea, Tudor I; Overington, John PAssay and drug development technologies.2015 Jul-Aug;299-30626241209
Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis.Stockton Jr, Steven D; Gomes, Ivone; Liu, Tong; Moraje, Chandrakala; Hipólito, Lucia; Jones, Matthew R; Ma'ayan, Avi; Morón, Jose A; Li, Hong; Devi, Lakshmi AMolecular & cellular proteomics : MCP.2015 Oct;2564-7626149443
Publisher?s Note:Abstraction for data integration:Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction.Rouillard, Andrew D; Wang, Zichen; Ma'ayan, AviComputational biology and chemistry.2015 Oct;104-1926101093
Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.Roth, Bryan L; Kroeze, Wesley KThe Journal of biological chemistry.2015 Aug 7;19471-726100629
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.Vardy, Eyal; Sassano, Maria F; Rennekamp, Andrew J; Kroeze, Wesley K; Mosier, Philip D; Westkaemper, Richard B; Stevens, Craig W; Katritch, Vsevolod; Stevens, Raymond C; Peterson, Randall T; Roth, Bryan LChemistry & biology.2015 Jun 18;764-7526091169
Dynamics of the discovery process of protein-protein interactions from low content studies.Wang, Zichen; Clark, Neil R; Ma'ayan, AviBMC systems biology.2015;2626048415
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.Boettcher, Michael; McManus, Michael TMolecular cell.2015 May 21;575-8526000843
GEO2Enrichr: browser extension and server app to extract gene sets from GEO and analyze them for biological functions.Gundersen, Gregory W; Jones, Matthew R; Rouillard, Andrew D; Kou, Yan; Monteiro, Caroline D; Feldmann, Axel S; Hu, Kevin S; Ma'ayan, AviBioinformatics (Oxford, England).2015 Sep 15;3060-225971742
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.Kroeze, Wesley K; Sassano, Maria F; Huang, Xi-Ping; Lansu, Katherine; McCorvy, John D; Giguère, Patrick M; Sciaky, Noah; Roth, Bryan LNature structural & molecular biology.2015 May;362-925895059
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains.Stuhlmiller, Timothy J; Miller, Samantha M; Zawistowski, Jon S; Nakamura, Kazuhiro; Beltran, Adriana S; Duncan, James S; Angus, Steven P; Collins, Kyla A L; Granger, Deborah A; Reuther, Rachel A; Graves, Lee M; Gomez, Shawn M; Kuan, Pei-Fen; Parker, Joel Cell reports.2015 Apr 21;390-40425865888
Cell-Based Screening: Extracting Meaning from Complex DataFinkbeiner S., Frumkin M., Kassner PDNeuron 2015 Apr 886(1):160-17425856492
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors.Tsai, Yihsuan S; Dominguez, Daniel; Gomez, Shawn M; Wang, ZefengOncotarget.2015 Mar 30;6825-3925749525
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders.Björkegren, Johan L M; Kovacic, Jason C; Dudley, Joel T; Schadt, Eric EJournal of the American College of Cardiology.2015 Mar 3;830-4525720628
Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions.Xu, Ke; Schadt, Eric E; Pollard, Katherine S; Roussos, Panos; Dudley, Joel TMolecular biology and evolution.2015 May;1148-6025681384
REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.Baida, Gleb; Bhalla, Pankaj; Kirsanov, Kirill; Lesovaya, Ekaterina; Yakubovskaya, Marianna; Yuen, Kit; Guo, Shuchi; Lavker, Robert M; Readhead, Ben; Dudley, Joel T; Budunova, IrinaEMBO molecular medicine.2015 Jan;42-5825504525
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme.Duarte, Luis F; Young, Andrew R J; Wang, Zichen; Wu, Hsan-Au; Panda, Taniya; Kou, Yan; Kapoor, Avnish; Hasson, Dan; Mills, Nicholas R; Ma'ayan, Avi; Narita, Masashi; Bernstein, EmilyNature communications.2014;521025394905
A blueprint of cell identity.Ma'ayan, Avi; Duan, QiaonanNature biotechnology.2014 Oct;1007-825299921
Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.Petrukhin, KonstantinDrug discovery today. Therapeutic strategies2013e11-e2025152755
Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification.Sahn, James J; Granger, Brett A; Martin, Stephen FOrganic & biomolecular chemistry2014 Aug 19NULL25135846
Lean Big Data integration in systems biology and systems pharmacology.Ma'ayan, Avi; Rouillard, Andrew D; Clark, Neil R; Wang, Zichen; Duan, Qiaonan; Kou, YanTrends in pharmacological sciences2014 Sep450-46025109570
Drug/Cell-line Browser: interactive canvas visualization of cancer drug/cell-line viability assay datasets.Duan, Qiaonan; Wang, Zichen; Fernandez, Nicolas F; Rouillard, Andrew D; Tan, Christopher M; Benes, Cyril H; Ma'ayan, AviBioinformatics (Oxford, England).2014 Nov 15;3289-9025100688
Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes.Yu, Yi-Yun; Georg, Gunda IAdvanced synthesis & catalysis2014 Apr 141359-136925071423
A high throughput flow cytometric assay platform targeting transporter inhibition.Tegos, George P; Evangelisti, Annette M; Strouse, J Jacob; Ursu, Oleg; Bologa, Cristian; Sklar, Larry ADrug discovery today. Technologies2014 June95-e10325027381
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Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis.Goller, Carlos C; Arshad, Mehreen; Noah, James W; Ananthan, Subramaniam; Evans, Carrie W; Nebane, N Miranda; Rasmussen, Lynn; Sosa, Melinda; Tower, Nichole A; White, E Lucile; Neuenswander, Benjamin; Porubsky, Patrick; Maki, Brooks E; Rogers, Steven A; ScPloS one2014e9605424983234
Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.Parks, Gregory S; Wang, Lien; Wang, Zhiwei; Civelli, OlivierThe Journal of comparative neurology2014 Jun 30NULL24978951
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Barmada, Sami J; Serio, Andrea; Arjun, Arpana; Bilican, Bilada; Daub, Aaron; Ando, D Michael; Tsvetkov, Andrey; Pleiss, Michael; Li, Xingli; Peisach, Daniel; Shaw, Christopher; Chandran, Siddharthan; Finkbeiner, StevenNature chemical biology.2014 Aug;24974230
Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process.Medda, Federico; Hulme, ChristopherTetrahedron letters2014 May 13328-333124954960
Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.Sully, Erin K; Malachowa, Natalia; Elmore, Bradley O; Alexander, Susan M; Femling, Jon K; Gray, Brian M; DeLeo, Frank R; Otto, Michael; Cheung, Ambrose L; Edwards, Bruce S; Sklar, Larry A; Horswill, Alexander R; Hall, Pamela R; Gresham, Hattie DPLoS pathogens2014 June100417424945495
Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction.Ayaz, Muhammad; Xu, Zhigang; Hulme, ChristopherTetrahedron letters2014 Jun 43406-340924932052
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.Duan, Qiaonan; Flynn, Corey; Niepel, Mario; Hafner, Marc; Muhlich, Jeremy L; Fernandez, Nicolas F; Rouillard, Andrew D; Tan, Christopher M; Chen, Edward Y; Golub, Todd R; Sorger, Peter K; Subramanian, Aravind; Ma'ayan, AviNucleic acids research2014 JulW449-6024906883
Enzyme inhibitor discovery by activity-based protein profiling.Niphakis, Micah J; Cravatt, Benjamin FAnnual review of biochemistry2014341-7724905785
Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum.Du, Lin; Robles, Andrew J; King, Jarrod B; Mooberry, Susan L; Cichewicz, Robert HJournal of natural products2014 Jun 271459-6624893224
Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi.Wijeratne, E M Kithsiri; Espinosa-Artiles, Patricia; Gruener, Raphael; Gunatilaka, A A LeslieJournal of natural products2014 Jun 271467-7224882589
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C; Li, Kelin; Lis, Lev G; Walters, Michael A; Schoenen, Frank J; Lin, Henry J; Deshaies, Raymond J; Arkin, Michelle RJournal of molecular biology2014 Jul 292886-9924878061
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor.Conn, P Michael; Smith, Emery; Spicer, Timothy; Chase, Peter; Scampavia, Louis; Janovick, Jo AnnAssay and drug development technologies2014 May238-4624831790
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.Sun, Haiyan; Wei, Ying; Deng, Huayun; Xiong, Qiaojie; Li, Min; Lahiri, Joydeep; Fang, YeScientific reports2014493424816792
Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays.Low, Yen Sia; Sedykh, Alexander Yeugenyevich; Rusyn, Ivan; Tropsha, AlexanderCurrent topics in medicinal chemistry20141356-6424805064
Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs.Wenthur, Cody J; Morrison, Ryan D; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig WBioorganic & medicinal chemistry letters2014 Jun 152693-824794112
Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella.Kwan, Jason C; Tianero, Ma Diarey B; Donia, Mohamed S; Wyche, Thomas P; Bugni, Tim S; Schmidt, Eric WPloS one2014e9585024788869
Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions.Martinez-Ariza, Guillermo; Ayaz, Muhammad; Medda, Federico; Hulme, ChristopherThe Journal of organic chemistry2014 Jun 65153-6224788091
Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from *-substituted *-hydroxyaminoaldehydes.Ranade, Adwait R; Georg, Gunda IThe Journal of organic chemistry2014 Feb 7984-9224785413
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.Abulwerdi, Fardokht A; Liao, Chenzhong; Mady, Ahmed S; Gavin, Jordan; Shen, Chenxi; Cierpicki, Tomasz; Stuckey, Jeanne A; Showalter, H D Hollis; Nikolovska-Coleska, ZanetaJournal of medicinal chemistry2014 May 224111-3324749893
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor.Yan, Fei; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; O'Malley, Bert W; Lonard, David MPloS one2014e9524324743578
Protein chaperones: a composition of matter review (2008 - 2013).Taldone, Tony; Patel, Hardik J; Bolaender, Alexander; Patel, Maulik R; Chiosis, GabrielaExpert opinion on therapeutic patents2014 May501-1824742089
Solvent-dependent divergent functions of Sc(OTf)ýýý in stereoselective epoxide-opening spiroketalizations.Sharma, Indrajeet; Wurst, Jacqueline M; Tan, Derek SOrganic letters2014 May 22474-724742081
Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth.Sarkisyan, Gor; Gay, Laurie J; Nguyen, Nhan; Felding, Brunhilde H; Rosen, HughAmerican journal of physiology. Cell physiology2014 Jul 1C14-2424740542
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.Oldstone, Michael B A; Rosen, HughCurrent topics in microbiology and immunology2014129-4724728596
Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.Swale, Daniel R; Kharade, Sujay V; Denton, Jerod SCurrent opinion in pharmacology2014 Apr15-Jul24721648
Evaluation of prostate-specific membrane antigen as an imaging reporter.Castanares, Mark A; Mukherjee, Amarnath; Chowdhury, Wasim H; Liu, Minzhi; Chen, Ying; Mease, Ronnie C; Wang, Yuchuan; Rodriguez, Ronald; Lupold, Shawn E; Pomper, Martin GJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014 May805-1124700883
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe.Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P JefChemMedChem2014 Apr 1NULL24692176
Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2.Gavrish, Ekaterina; Sit, Clarissa S; Cao, Shugeng; Kandror, Olga; Spoering, Amy; Peoples, Aaron; Ling, Losee; Fetterman, Ashley; Hughes, Dallas; Bissell, Anthony; Torrey, Heather; Akopian, Tatos; Mueller, Andreas; Epstein, Slava; Goldberg, Alfred; Clardy,Chemistry & biology2014 Apr 24509-1824684906
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.Rai, Ganesha; Joshi, Netra; Jung, Joo Eun; Liu, Yu; Schultz, Lena; Yasgar, Adam; Perry, Steve; Diaz, Giovanni; Zhang, Qiangli; Kenyon, Victor; Jadhav, Ajit; Simeonov, Anton; Lo, Eng H; van Leyen, Klaus; Maloney, David J; Holman, Theodore RJournal of medicinal chemistry2014 May 224035-4824684213
Protein phosphatases in pancreatic islets.Ortsater, Henrik; Grankvist, Nina; Honkanen, Richard E; Sjoholm, AkeThe Journal of endocrinology2014 JunR121-R14424681827
Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy.Walsh, Kevin B; Teijaro, John R; Brock, Linda G; Fremgen, Daniel M; Collins, Peter L; Rosen, Hugh; Oldstone, Michael B AJournal of virology2014 Jun6281-9324672024
The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions.Prohaska, Kimberly M; Bennett, Ryan P; Salter, Jason D; Smith, Harold CWiley interdisciplinary reviews. RNA2014 Mar 24NULL24664896
Synthesis of novel peptidyl adenosine antibiotic analogs.Moukha-Chafiq, Omar; Reynolds, Robert CNucleosides, nucleotides & nucleic acids201453-6324660880
Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis.Kim, Yong Wook; Georg, Gunda IOrganic letters2014 Mar 211574-724650204
In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.Mandal, Nawajes A; Tran, Julie-Thu A; Zheng, Lixin; Wilkerson, Joseph L; Brush, Richard S; McRae, Joel; Agbaga, Martin-Paul; Zhang, Kang; Petrukhin, Konstantin; Ayyagari, Radha; Anderson, Robert EInvestigative ophthalmology & visual science2014 Apr2705-1324644051
A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence.Vekariya, Rakesh H; Liu, Ruzhang; Aube, JeffreyOrganic letters2014 Apr 41844-724635056
Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.Pagano, Nicholas; Heil, Marintha L; Cosford, Nicholas D PSynthesis20122537-254624634547
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor.Yuan, Hsiangkuo; Wilson, Christy M; Xia, Jun; Doyle, Sarah L; Li, Shuqin; Fales, Andrew M; Liu, Yang; Ozaki, Ema; Mulfaul, Kelly; Hanna, Gabi; Palmer, Gregory M; Wang, Lihong V; Grant, Gerald A; Vo-Dinh, TuanNanoscale2014 Apr 214078-8224619405
Equilibrium and kinetics of Sin Nombre hantavirus binding at DAF/CD55 functionalized bead surfaces.Buranda, Tione; Swanson, Scarlett; Bondu, Virginie; Schaefer, Leah; Maclean, James; Mo, Zhenzhen; Wycoff, Keith; Belle, Archana; Hjelle, BrianViruses20141091-11124618810
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora.Ziemert, Nadine; Lechner, Anna; Wietz, Matthias; Millan-Aguinaga, Natalie; Chavarria, Krystle L; Jensen, Paul RobertProceedings of the National Academy of Sciences of the United States of America2014 Mar 25E1130-924616526
A chimeric siderophore halts swarming Vibrio.Bottcher, Thomas; Clardy, JonAngewandte Chemie (International ed. in English)2014 Mar 243510-324615751
Discovery of ML314, a Brain Penetrant Non-Peptidic *-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick R; Li, Yujie; Milewski, Monika; Gosalia, Palak; Gray, Wilson; Mehta, Alka; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Heynen-Genel, Susanne; Vasile, StefaACS medicinal chemistry letters2013 Jul 20846-85124611085
Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy.Teijaro, John R; Walsh, Kevin B; Long, James P; Tordoff, Kevin P; Stark, Gregory V; Eisfeld, Amie J; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B AVirology2014 Mar152-724606692
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.Brahimi, Fouad; Ko, Eunhwa; Malakhov, Andrey; Burgess, Kevin; Saragovi, H UriPloS one2014e8961724603864
Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation.Kwan, Jason C; Liu, Yanxia; Ratnayake, Ranjala; Hatano, Ryo; Kuribara, Akiko; Morimoto, Chiko; Ohnuma, Kei; Paul, Valerie J; Ye, Tao; Luesch, HendrikChembiochem : a European journal of chemical biology2014 Apr 14799-80424591193
Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor ýý is therapeutic in the collagen-induced arthritis experimental model.Chang, Mi Ra; Lyda, Brent; Kamenecka, Theodore M; Griffin, Patrick RArthritis & rheumatology (Hoboken, N.J.)2014 Mar579-8824574218
Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking.Gonzalez, David J; Vuong, Lisa; Gonzalez, Isaiah S; Keller, Nadia; McGrosso, Dominic; Hwang, John H; Hung, Jun; Zinkernagel, Annelies; Dixon, Jack E; Dorrestein, Pieter C; Nizet, VictorMolecular & cellular proteomics : MCP2014 May1262-7224567418
Diastereoselective synthesis of ýý- and ýý-lactams from imines and sulfone-substituted anhydrides.Sorto, Nohemy A; Di Maso, Michael J; Munoz, Manuel A; Dougherty, Ryan J; Fettinger, James C; Shaw, Jared TThe Journal of organic chemistry2014 Mar 212601-1024552208
MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines.Bell, Christan E; Shaw, Arthur Y; De Moliner, Fabio; Hulme, ChristopherTetrahedron2014 Jan 754-5924535889
Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.Ellis, Gregory A; Wyche, Thomas P; Fry, Charles G; Braun, Doug R; Bugni, Tim SMarine drugs2014 Feb1013-2224534844
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.Gregory, Karen J; Nguyen, Elizabeth D; Malosh, Chrysa; Mendenhall, Jeffrey L; Zic, Jessica Z; Bates, Brittney S; Noetzel, Meredith J; Squire, Emma F; Turner, Eric M; Rook, Jerri M; Emmitte, Kyle A; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn,ACS chemical neuroscience2014 Apr 16282-9524528109
M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses.Pancani, Tristano; Bolarinwa, Caroline; Smith, Yoland; Lindsley, Craig W; Conn, P Jeffrey; Xiang, ZixiuACS chemical neuroscience2014 Apr 16318-2424528004
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis.Bandyopadhyay, Sanghamitra; Rogers, Jack TBiochemical pharmacology2014 Apr 15486-9424513321
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor.Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry ACurrent protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.]20149.43.1-9.43.1124510772
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor.Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry ACurrent protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.]20149.43.1-9.43.1124510772
Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.Xie, Pengfei; Ma, Ming; Rateb, Mostafa E; Shaaban, Khaled A; Yu, Zhiguo; Huang, Sheng-Xiong; Zhao, Li-Xing; Zhu, Xiangcheng; Yan, Yijun; Peterson, Ryan M; Lohman, Jeremy R; Yang, Dong; Yin, Min; Rudolf, Jeffrey D; Jiang, Yi; Duan, Yanwen; Shen, BenJournal of natural products2014 Feb 28377-8724484381
Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.Neochoritis, Constantinos G; Domling, AlexanderOrganic & biomolecular chemistry2014 Mar 141649-5124477767
Programmed death-1: therapeutic success after more than 100ýýýyears of cancer immunotherapy.Domling, Alexander; Holak, Tad AAngewandte Chemie (International ed. in English)2014 Feb 242286-824474145
Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons.Fan, Longchang; Guan, Xiaowei; Wang, Wei; Zhao, Jian-Yuan; Zhang, Hongkang; Tiwari, Vinod; Hoffman, Paul N; Li, Min; Tao, Yuan-XiangMolecular pain2014824472174
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.He, Shihan; Senter, Timothy J; Pollock, Jonathan; Han, Changho; Upadhyay, Sunil Kumar; Purohit, Trupta; Gogliotti, Rocco D; Lindsley, Craig W; Cierpicki, Tomasz; Stauffer, Shaun R; Grembecka, JolantaJournal of medicinal chemistry2014 Feb 271543-5624472025
Chemo- and site-selective derivatizations of natural products enabling biological studies.Robles, Omar; Romo, DanielNatural product reports2014 Mar318-3424468713
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza.Gao, Wei; Sun, Hai-Xi; Xiao, Hongbin; Cui, Guanghong; Hillwig, Matthew L; Jackson, Alana; Wang, Xiao; Shen, Ye; Zhao, Nan; Zhang, Liangxiao; Wang, Xiu-Jie; Peters, Reuben J; Huang, LuqiBMC genomics20147324467826
A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.Lewallen, Daniel M; Bicker, Kevin L; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul RACS chemical biology2014 Apr 18913-2124467619
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres.Sheffler, Douglas J; Nedelovych, Michael T; Williams, Richard; Turner, Stephen C; Duerk, Brittany B; Robbins, Megan R; Jadhav, Sataya B; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Daniels, R Nathan; Lindsley, Craig WBioorganic & medicinal chemistry letters2014 Feb 151062-624462664
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.Jones, Carrie K; Sheffler, Douglas J; Williams, Richard; Jadhav, Sataya B; Felts, Andrew S; Morrison, Ryan D; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig WBioorganic & medicinal chemistry letters2014 Feb 151067-7024461352
A novel class of ion displacement ligands as antagonists of the *IIb*3 receptor that limit conformational reorganization of the receptor.Jiang, Jian-kang; McCoy, Joshua G; Shen, Min; LeClair, Christopher A; Huang, Wenwei; Negri, Ana; Li, Jihong; Blue, Robert; Harrington, Amanda Weil; Naini, Sarasija; David 3rd, George; Choi, Won-Seok; Volpi, Elisabetta; Fernandez, Joseph; Babayeva, MarianaBioorganic & medicinal chemistry letters2014 Feb 151148-5324461295
Probing chemical space with alkaloid-inspired libraries.McLeod, Michael C; Singh, Gurpreet; Plampin 3rd, James N; Rane, Digamber; Wang, Jenna L; Day, Victor W; Aube, JeffreyNature chemistry2014 Feb133-4024451589
Chemical modulation of glycerolipid signaling and metabolic pathways.Scott, Sarah A; Mathews, Thomas P; Ivanova, Pavlina T; Lindsley, Craig W; Brown, H AlexBiochimica et biophysica acta2014 Jan 15NULL24440821
Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.Dreyton, Christina J; Anderson, Erin D; Subramanian, Venkataraman; Boger, Dale L; Thompson, Paul RBioorganic & medicinal chemistry2014 Feb 151362-924440480
Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model.Aldrich, Leslie N; Berry, Cynthia B; Bates, Brittney S; Konkol, Leah C; So, Miranda; Lindsley, Craig WEuropean journal of organic chemistry2013 Jul 1NULL24415906
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.Ardecky, Robert J; Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Brown, Brock; Ganji, Santhi; Zou, Jiwen; Pass, Ian; Narisawa, Sonoko; Iano, Flavia Godoy; Rosenstein, Craig; Cheltsov, Anton; Rascon, Justin; Hedrick, Michael; Gasior, Carlton; Forster, Anita;Bioorganic & medicinal chemistry letters2014 Feb 11000-424412070
The University of New Mexico Center for Molecular Discovery.Edwards, Bruce S; Gouveia, Kristine; Oprea, Tudor I; Sklar, Larry ACombinatorial chemistry & high throughput screening2014 Mar256-6524409953
Collaborative pre-competitive preclinical drug discovery with academics and pharma/biotech partners at Sanford|Burnham: infrastructure, capabilities & operational models.Chung, Thomas D YCombinatorial chemistry & high throughput screening2014 Mar272-8924409951
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.Huang, Yijun; Wolf, Siglinde; Beck, Barbara; Kohler, Lisa-Maria; Khoury, Kareem; Popowicz, Grzegorz M; Goda, Sayed K; Subklewe, Marion; Twarda, Aleksandra; Holak, Tad A; Domling, AlexanderACS chemical biology2014 Mar 21802-1124405416
Covalent inhibition of the lymphoid tyrosine phosphatase.Ahmed, Vanessa F; Bottini, Nunzio; Barrios, Amy MChemMedChem2014 Feb296-924403103
Grubbs cross-metathesis pathway for a scalable synthesis of ýý-keto-*,*-unsaturated esters.Nair, Reji N; Bannister, Thomas DThe Journal of organic chemistry2014 Feb 71467-7224393145
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.Luci, Diane K; Jameson 2nd, J Brian; Yasgar, Adam; Diaz, Giovanni; Joshi, Netra; Kantz, Auric; Markham, Kate; Perry, Steve; Kuhn, Norine; Yeung, Jennifer; Kerns, Edward H; Schultz, Lena; Holinstat, Michael; Nadler, Jerry L; Taylor-Fishwick, David A; JadhaJournal of medicinal chemistry2014 Jan 23495-50624393039
Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.Wang, Ying; Lonard, David M; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy G; Wang, Jin; Qi, Ruogu; Matzuk, Alexander J; Song, Xianzhou; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; Zhou, Suoling; Liao, Lan; Xu, Jianming; O'Malley, BertCancer research2014 Mar 11506-1724390736
A novel analgesic isolated from a traditional chinese medicine.Zhang, Yan; Wang, Chaoran; Wang, Lien; Parks, Gregory Scott; Zhang, Xiuli; Guo, Zhimou; Ke, Yanxiong; Li, Kang-Wu; Kim, Mi Kyeong; Vo, Benjamin; Borrelli, Emiliana; Ge, Guangbo; Yang, Ling; Wang, Zhiwei; Garcia-Fuster, M Julia; Luo, Z David; Liang, XinmiaCurrent biology : CB2014 Jan 20117-2324388848
High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity.Ofori, Leslie O; Hilimire, Thomas A; Bennett, Ryan P; Brown Jr, Nathaniel W; Smith, Harold C; Miller, Benjamin LJournal of medicinal chemistry2014 Feb 13723-3224387306
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Chris A; Bi, Danse; Basha, Fatima Z; Hanson, Paul RHeterocycles2012 Dec 31NULL24385680
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol.Zang, Qin; Zhou, Aihua; Javed, Salim; Maity, Pradip K; Knudtson, Chris A; Bi, Danse; Hastings, Jared J; Basha, Fatima Z; Hanson, Paul RHeterocycles2012 Dec 31NULL24385679
Activation of the nuclear factor e2-related factor 2 pathway by novel natural products halomadurones a-d and a synthetic analogue.Wyche, Thomas P; Standiford, Miranda; Hou, Yanpeng; Braun, Doug; Johnson, Delinda A; Johnson, Jeffrey A; Bugni, Tim SMarine drugs20135089-9924351907
Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles.MacDonald, Jacob P; Shupe, Benjamin H; Schreiber, John D; Franz, Annaliese KChemical communications (Cambridge, England)2014 May 255242-424336395
Imidazole-derived agonists for the neurotensin 1 receptor.Hershberger, Paul M; Hedrick, Michael P; Peddibhotla, Satyamaheshwar; Mangravita-Novo, Arianna; Gosalia, Palak; Li, Yujie; Gray, Wilson; Vicchiarelli, Michael; Smith, Layton H; Chung, Thomas D Y; Thomas, James B; Caron, Marc G; Pinkerton, Anthony B; BarakBioorganic & medicinal chemistry letters2014 Jan 1262-724332089
A simple one-pot 2-step N-1-alkylation of indoles with *-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles.Martinez-Ariza, Guillermo; Ayaz, Muhammad; Hulme, ChristopherTetrahedron letters2013 Dec 4NULL24327792
Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones.Singh, Gurpreet; Meyer, Angelica; Aube, JeffreyThe Journal of organic chemistry2014 Jan 3452-824325280
Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism.Kwan, Jason C; Schmidt, Eric WPloS one2013e8082224324632
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.Zaytseva, Natalya; Lynn, Jeffery G; Wu, Qi; Mudaliar, Deepti J; Sun, Haiyan; Kuang, Patty Q; Fang, YeSensors and actuators. B, Chemical2013 NovNULL24319319
High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.Sharma, Kamal; Choi, Se-Young; Zhang, Yong; Nieland, Thomas J F; Long, Shunyou; Li, Min; Huganir, Richard LCell reports2013 Dec 121330-4124316074
Application of ion-sensitive field effect transistors for ion channel screening.Walsh, Kenneth B; DeRoller, Nicholas; Zhu, Yihao; Koley, GoutamBiosensors & bioelectronics2014 Apr 15448-5424315877
Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams.Asad, Naeem; Samarakoon, Thiwanka B; Zang, Qin; Loh, Joanna K; Javed, Salim; Hanson, Paul ROrganic letters2014 Jan 382-524313225
Multiplex cytological profiling assay to measure diverse cellular states.Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Sokolnicki, Katherine L; Anthony Wilson, J; Walpita, Deepika; Kemp, Melissa M; Petri Seiler, Kathleen; Carrel, Hyman A; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Carpenter, Anne E; Shamji, Alykhan FPloS one2013e8099924312513
Multiplex cytological profiling assay to measure diverse cellular states.Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Sokolnicki, Katherine L; Anthony Wilson, J; Walpita, Deepika; Kemp, Melissa M; Petri Seiler, Kathleen; Carrel, Hyman A; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Carpenter, Anne E; Shamji, Alykhan FPloS one2013e8099924312513
Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.Yun, Bogeon; Lee, HeeJung; Ghosh, Moumita; Cravatt, Benjamin F; Hsu, Ku-Lung; Bonventre, Joseph V; Ewing, Heather; Gelb, Michael H; Leslie, Christina CThe Journal of biological chemistry2014 Jan 171491-50424297180
An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support.Fei, Yiyan; Landry, James P; Li, Yanhong; Yu, Hai; Lau, Kam; Huang, Shengshu; Chokhawala, Harshal A; Chen, Xi; Zhu, X DThe Review of scientific instruments2013 Nov11410224289409
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.Doherty, Joanne R; Yang, Chunying; Scott, Kristen E N; Cameron, Michael D; Fallahi, Mohammad; Li, Weimin; Hall, Mark A; Amelio, Antonio L; Mishra, Jitendra K; Li, Fangzheng; Tortosa, Mariola; Genau, Heide Marika; Rounbehler, Robert J; Lu, Yunqi; Dang, ChiCancer research2014 Feb 1908-2024285728
Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity.Du, Lin; Robles, Andrew J; King, Jarrod B; Powell, Douglas R; Miller, Andrew N; Mooberry, Susan L; Cichewicz, Robert HAngewandte Chemie (International ed. in English)2014 Jan 13804-924285637
Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating.Zhang, Qiansen; Zhou, Pingzheng; Chen, Zhuxi; Li, Min; Jiang, Hualiang; Gao, Zhaobing; Yang, HuaiyuProceedings of the National Academy of Sciences of the United States of America2013 Dec 1020093-824277843
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.Kotsikorou, Evangelia; Sharir, Haleli; Shore, Derek M; Hurst, Dow P; Lynch, Diane L; Madrigal, Karla E; Heynen-Genel, Susanne; Milan, Loribelle B; Chung, Thomas D Y; Seltzman, Herbert H; Bai, Yushi; Caron, Marc G; Barak, Larry S; Croatt, Mitchell P; AboodBiochemistry2013 Dec 319456-6924274581
Inhibiting AMPylation: A Novel Screen To Identify the First Small Molecule Inhibitors of Protein AMPylation.Lewallen, Daniel M; Sreelatha, Anju; Dharmarajan, Venkatasubramanian; Madoux, Franck; Chase, Peter; Griffin, Patrick R; Orth, Kim; Hodder, Peter; Thompson, Paul RACS chemical biology2013 Nov 25NULL24274060
Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.Raphemot, Rene; Kadakia, Rishin J; Olsen, Michelle L; Banerjee, Sreedatta; Days, Emily; Smith, Stephen S; Weaver, C David; Denton, Jerod SAssay and drug development technologies2013 Nov-Dec532-4324266659
Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.Bruntz, Ronald C; Taylor, Harry E; Lindsley, Craig W; Brown, H AlexThe Journal of biological chemistry2014 Jan 10600-1624257753
Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC).Chen, Haijun; Wild, Christopher; Zhou, Xiaobin; Ye, Na; Cheng, Xiaodong; Zhou, JiaJournal of medicinal chemistry2013 Nov 27NULL24256330
Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A-E, Five Sesterterpenoids from Emericella sp. AST0036, a Fungal Endophyte of Astragalus lentiginosus1.Xu, Ya-Ming; Espinosa-Artiles, Patricia; Liu, Mangping X; Arnold, A Elizabeth; Gunatilaka, A A LeslieJournal of natural products2013 Nov 19NULL24251417
Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Hanson, Paul R; Organ, Michael GJournal of flow chemistry2012 DecNULL24244871
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Ullah, Farman; Zang, Qin; Javed, Salim; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul R; Organ, Michael GSynthesis2012NULL24244052
Deorphanizing the human transmembrane genome: A landscape of uncharacterized membrane proteins.Babcock, Joseph J; Li, MinActa pharmacologica Sinica2014 Jan23-Nov24241348
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.Deng, Xianming; Elkins, Jonathan M; Zhang, Jinwei; Yang, Qingkai; Erazo, Tatiana; Gomez, Nestor; Choi, Hwan Geun; Wang, Jinhua; Dzamko, Nicolas; Lee, Jiing-Dwan; Sim, Taebo; Kim, Namdoo; Alessi, Dario R; Lizcano, Jose M; Knapp, Stefan; Gray, Nathanael SEuropean journal of medicinal chemistry2013 Dec758-6724239623
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.Deng, Xianming; Elkins, Jonathan M; Zhang, Jinwei; Yang, Qingkai; Erazo, Tatiana; Gomez, Nestor; Choi, Hwan Geun; Wang, Jinhua; Dzamko, Nicolas; Lee, Jiing-Dwan; Sim, Taebo; Kim, NamDoo; Alessi, Dario R; Lizcano, Jose M; Knapp, Stefan; Gray, Nathanael SEuropean journal of medicinal chemistry2013 Dec758-6724239623
Inhibition of the TRPC5 ion channel protects the kidney filter.Schaldecker, Thomas; Kim, Sookyung; Tarabanis, Constantine; Tian, Dequan; Hakroush, Samy; Castonguay, Philip; Ahn, Wooin; Wallentin, Hanna; Heid, Hans; Hopkins, Corey R; Lindsley, Craig W; Riccio, Antonio; Buvall, Lisa; Weins, Astrid; Greka, AnnaThe Journal of clinical investigation2013 Dec 25298-30924231357
Transient protein states in designing inhibitors of the MDM2-p53 interaction.Bista, Michal; Wolf, Siglinde; Khoury, Kareem; Kowalska, Kaja; Huang, Yijun; Wrona, Ewa; Arciniega, Marcelino; Popowicz, Grzegorz M; Holak, Tad A; Domling, AlexanderStructure (London, England : 1993)2013 Dec 32143-5124207125
Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.Li, Min; Khambu, Bilon; Zhang, Hao; Kang, Jeong-Han; Chen, Xiaoyun; Chen, Daohong; Vollmer, Laura; Liu, Pei-Qing; Vogt, Andreas; Yin, Xiao-MingThe Journal of biological chemistry2013 Dec 1335769-8024174532
Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig WJournal of medicinal chemistry2013 Nov 279351-524164599
HIV-1 accessory proteins: VpR.Zhao, Richard Y; Bukrinsky, Michael IMethods in molecular biology (Clifton, N.J.)2014125-3424158819
Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.Hsu, Ku-Lung; Tsuboi, Katsunori; Whitby, Landon R; Speers, Anna E; Pugh, Holly; Inloes, Jordon; Cravatt, Benjamin FJournal of medicinal chemistry2013 Nov 148257-6924152245
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus.Liu, Wei-Ting; Lamsa, Anne; Wong, Weng Ruh; Boudreau, Paul D; Kersten, Roland; Peng, Yao; Moree, Wilna J; Duggan, Brendan M; Moore, Bradley S; Gerwick, William H; Linington, Roger G; Pogliano, Kit; Dorrestein, Pieter CThe Journal of antibiotics2013 Oct 23NULL24149839
Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans.Stefan, Christopher P; Cunningham, Kyle WThe Journal of biological chemistry2013 Nov 2934861-7024142703
Human protamine-1 as an MRI reporter gene based on chemical exchange.Bar-Shir, Amnon; Liu, Guanshu; Chan, Kannie W Y; Oskolkov, Nikita; Song, Xiaolei; Yadav, Nirbhay N; Walczak, Piotr; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf AACS chemical biology2014 Jan 17134-824138139
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.Guerrero, Miguel; Poddutoori, Ramulu; Urbano, Mariangela; Peng, Xuemei; Spicer, Timothy P; Chase, Peter S; Hodder, Peter S; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2013 Dec 16346-924135724
Modulators of the Sphingosine 1-phosphate receptor 1.Urbano, Mariangela; Guerrero, Miguel; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2013 Dec 16377-8924125884
Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI.Liu, Guanshu; Bettegowda, Chetan; Qiao, Yuan; Staedtke, Verena; Chan, Kannie W Y; Bai, Renyuan; Li, Yuguo; Riggins, Gregory J; Kinzler, Kenneth W; Bulte, Jeff W M; McMahon, Michael T; Gilad, Assaf A; Vogelstein, Bert; Zhou, Shibin; van Zijl, Peter C MMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2013 Dec1690-824123389
A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth.May, Elebeoba E; Leitao, Andrei; Tropsha, Alexander; Oprea, Tudor IComputational biology and chemistry2013 Dec167-8024121675
Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3).Robinson, James; Smith, Anthony; Sturchler, Emmanuel; Tabrizifard, Sahba; Kamenecka, Theodore; McDonald, PatriciaAssay and drug development technologies2013 Oct468-7724116939
A pilot biomedical engineering course in rapid prototyping for mobile health.Stokes, Todd H; Venugopalan, Janani; Hubbard, Elena N; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference20132515-824110238
Challenges and triumphs to genomics-based natural product discovery.Jensen, Paul R; Chavarria, Krystle L; Fenical, William; Moore, Bradley S; Ziemert, NadineJournal of industrial microbiology & biotechnology2014 Feb203-924104399
A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90).Shahinas, Dea; Folefoc, Asongna; Taldone, Tony; Chiosis, Gabriela; Crandall, Ian; Pillai, Dylan RPloS one2013e7544624098696
Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation.Wan, Xia; Lu, Yungang; Chen, Xueqin; Xiong, Jian; Zhou, Yuanda; Li, Ping; Xia, Bingqing; Li, Min; Zhu, Michael X; Gao, ZhaobingPflugers Archiv : European journal of physiology2014 Jul1273-8724092046
Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella.Chibebe Junior, Jose; Sabino, Caetano P; Tan, Xiaojiang; Junqueira, Juliana C; Wang, Yan; Fuchs, Beth B; Jorge, Antonio O C; Tegos, George P; Hamblin, Michael R; Mylonakis, EleftheriosBMC microbiology201321724083556
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.Turlington, Mark; Chun, Aspen; Tomar, Sakshi; Eggler, Aimee; Grum-Tokars, Valerie; Jacobs, Jon; Daniels, J Scott; Dawson, Eric; Saldanha, Adrian; Chase, Peter; Baez-Santos, Yahira M; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew D; Stauffer, Shaun RBioorganic & medicinal chemistry letters2013 Nov 156172-724080461
Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751.Wijeratne, E M Kithsiri; He, Hongping; Franzblau, Scott G; Hoffman, Angela M; Gunatilaka, A A LeslieJournal of natural products2013 Oct 251860-524079882
Stereocontrol in asymmetric ýý-lactam syntheses from imines and cyanosuccinic anhydrides.Pattawong, Ommidala; Tan, Darlene Q; Fettinger, James C; Shaw, Jared T; Cheong, Paul Ha-YeonOrganic letters2013 Oct 45130-324070216
Stereoselective synthesis of ýý-lactams from imines and cyanosuccinic anhydrides.Tan, Darlene Q; Younai, Ashkaan; Pattawong, Ommidala; Fettinger, James C; Cheong, Paul Ha-Yeon; Shaw, Jared TOrganic letters2013 Oct 45126-924070117
Synthesis and Characterization of Thiolate-Oxo Ligated Zinc Alkyl Derivatives for Production of Zn-Based Nanoparticles.Boyle, Timothy J; Pratt 3rd, Harry D; Alam, Todd M; Headley, Thomas; Rodriguez, Mark AEuropean journal of inorganic chemistry2009 Mar 1855-86524068879
Indolo[3,2-a]carbazoles from a deep-water sponge of the genus Asteropus.Russell, Floyd; Harmody, Dedra; McCarthy, Peter J; Pomponi, Shirley A; Wright, Amy EJournal of natural products2013 Oct 251989-9224063539
The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm.Kapur, Sunil; Macrae, Calum AFrontiers in physiology201322124062689
Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy.Vo-Dinh, Tuan; Fales, Andrew M; Griffin, Guy D; Khoury, Christopher G; Liu, Yang; Ngo, Hoan; Norton, Stephen J; Register, Janna K; Wang, Hsin-Neng; Yuan, HsiangkuoNanoscale2013 Nov 710127-4024056945
Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide Turlington, Mark; Noetzel, Meredith J; Chun, Aspen; Zhou, Ya; Gogliotti, Rocco D; Nguyen, Elizabeth D; Gregory, Karen J; Vinson, Paige N; Rook, Jerri M; Gogi, Kiran K; Xiang, Zixiu; Bridges, Thomas M; Daniels, J Scott; Jones, Carrie; Niswender, Colleen M;Journal of medicinal chemistry2013 Oct 247976-9624050755
Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.NULLDrug discovery today. Technologies2013e219-31424050278
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.Ljosa, Vebjorn; Caie, Peter D; Ter Horst, Rob; Sokolnicki, Katherine L; Jenkins, Emma L; Daya, Sandeep; Roberts, Mark E; Jones, Thouis R; Singh, Shantanu; Genovesio, Auguste; Clemons, Paul A; Carragher, Neil O; Carpenter, Anne EJournal of biomolecular screening2013 Dec1321-924045582
Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.Storaska, Andrew J; Mei, Jian P; Wu, Meng; Li, Min; Wade, Susan M; Blazer, Levi L; Sjogren, Benita; Hopkins, Corey R; Lindsley, Craig W; Lin, Zhihong; Babcock, Joseph J; McManus, Owen B; Neubig, Richard RCellular signalling2013 Dec2848-5524041654
Identification of Potent and Selective Diphenylpropanamide RORýý Inhibitors.Huh, Jun R; Englund, Erika E; Wang, Hang; Huang, Ruili; Huang, Pengxiang; Rastinejad, Fraydoon; Inglese, James; Austin, Christopher P; Johnson, Ronald L; Huang, Wenwei; Littman, Dan RACS medicinal chemistry letters2013 Jan 1079-8424040486
A general, enantioselective synthesis of ýý- and ýý-fluoroamines.O'Reilly, Matthew C; Lindsley, Craig WTetrahedron letters2013 Jul 103627-362924039308
Nuclear magnetic resonance at the picomole level of a DNA adduct.Kautz, Roger; Wang, Poguang; Giese, Roger WChemical research in toxicology2013 Oct 211424-924028148
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In vitro and In vivo.Abulwerdi, Fardokht; Liao, Chenzhong; Liu, Meilan; Azmi, Asfar S; Aboukameel, Amro; Mady, Ahmed Sa; Gulappa, Thippeswamy; Cierpicki, Tomasz; Owens, Scott; Zhang, Tao; Sun, Duxin; Stuckey, Jeanne A; Mohammad, Ramzi M; Nikolovska-Coleska, ZanetaMolecular cancer therapeutics2013 Sep 9NULL24019208
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.Rosenthal, Andrew S; Dexheimer, Thomas S; Gileadi, Opher; Nguyen, Giang H; Chu, Wai Kit; Hickson, Ian D; Jadhav, Ajit; Simeonov, Anton; Maloney, David JBioorganic & medicinal chemistry letters2013 Oct 155660-624012121
Amphiphilic suramin dissolves Matrigel, causing an 'inhibition' artefact within in vitro angiogenesis assays.Prigozhina, Natalie L; Heisel, Andrew J; Seldeen, Jordan R; Cosford, Nicholas D P; Price, Jeffrey HInternational journal of experimental pathology2013 Dec412-723998420
Size and crystallinity in protein-templated inorganic nanoparticles.Jolley, Craig C; Uchida, Masaki; Reichhardt, Courtney; Harrington, Richard; Kang, Sebyung; Klem, Michael T; Parise, John B; Douglas, TrevorChemistry of materials : a publication of the American Chemical Society2010 Aug 244612-461823997427
Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade.Gunawan, Steven; Hulme, ChristopherTetrahedron letters2013 Aug 144467-447023997316
A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia.Singh, Harpreet; Shelat, Anang A; Singh, Amandeep; Boulos, Nidal; Williams, Richard T; Guy, R KiplinJournal of biomolecular screening2014 Jan158-6723989453
Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells: Comparing HTS Results from 1536-Well Plate-Based and High-Content Platforms.Sugarman, Eliot; Koo, Ada; Suyama, Eigo; Ruidiaz, Manuel E; Heynen-Genel, Susanne; Nguyen, Kevin H; Vasile, Stefan; Soundarapandian, Mangala M; Vega, Rick B; Kelly, Daniel P; Smith, Layton H; Malany, SiobhanJournal of biomolecular screening2014 Jan77-8723989452
A High-Voltage Integrated Circuit Engine for a Dielectrophoresis-based Programmable Micro-Fluidic Processor.Current, K Wayne; Yuk, Kelvin; McConaghy, Charles; Gascoyne, Peter R C; Schwartz, Jon A; Vykoukal, Jody V; Andrews, CraigProceedings ... International Conference on MEMS, NANO, and Smart Systems. International Conference on MEMS, NANO, and Smart Systems2005 Jul 24153-15823989241
Spectral bounds on plasmon resonances for Ag and Au prolate and oblate nanospheroids.Norton, Stephen J; Vo-Dinh, TuanJournal of nanophotonics2008 Sep 26NULL23977404
Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization.Khoury, Christopher G; Vo-Dinh, TuanThe journal of physical chemistry. C, Nanomaterials and interfaces200818849-1885923977403
Assessing the Location of Surface Plasmons Over Nanotriangle and Nanohole Arrays of Different Size and Periodicity.Correia-Ledo, Debby; Gibson, Kirsty F; Dhawan, Anuj; Couture, Maxime; Vo-Dinh, Tuan; Graham, Duncan; Masson, Jean-FrancoisThe journal of physical chemistry. C, Nanomaterials and interfaces2012 Mar 296884-689223977402
Theoretical Simulation and Focused Ion Beam Fabrication of Gold Nanostructures For Surface-Enhanced Raman Scattering (SERS).Dhawan, Anuj; Gerhold, Michael; Vo-Dinh, TuanNanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences2007 Dec164-17123976888
Plasmon Resonances of Nanoshells of Spheroidal Shape.Norton, Stephen J; Vo-Dinh, TuanIEEE transactions on nanotechnology2007627-63823976876
FIB Fabrication of Metallic Nanostructures on End-Faces of Optical Fibers for Chemical Sensing Applications.Dhawan, A; Muth, J F; Leonard, D N; Gerhold, M D; Gleeson, J; Vo-Dinh, T; Russell, P EJournal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society20082168-217323976838
Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.Arnold, David M; Laporte, Matthew G; Anderson, Shelby M; Wipf, PeterTetrahedron2013 Sep 97719-773123976798
Small-molecule antagonists of melanopsin-mediated phototransduction.Jones, Kenneth A; Hatori, Megumi; Mure, Ludovic S; Bramley, Jayne R; Artymyshyn, Roman; Hong, Sang-Phyo; Marzabadi, Mohammad; Zhong, Huailing; Sprouse, Jeffrey; Zhu, Quansheng; Hartwick, Andrew T E; Sollars, Patricia J; Pickard, Gary E; Panda, SatchidananNature chemical biology2013 Oct630-523974117
On the Nonnegative Rank of Euclidean Distance Matrices.Lin, Matthew M; Chu, Moody TLinear algebra and its applications2010 Sep 1681-68923966751
Parameter Reconstruction of Vibration Systems from Partial Eigeninformation.Dong, Bo; Lin, Matthew M; Chu, Moody TJournal of sound and vibration2009 Nov 13391-40123966750
Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions.Nguyen, Huy H; Palazzo, Teresa A; Kurth, Mark JOrganic letters2013 Sep 64492-523961714
Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues.Schulte, Michael L; Turlington, Mark L; Phatak, Sharangdhar S; Harp, Joel M; Stauffer, Shaun R; Lindsley, Craig WChemistry (Weinheim an der Bergstrasse, Germany)2013 Aug 16NULL23956045
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-ýýýýC]pyruvate.Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B; Larson, Peder E Z; Harzstark, Andrea L; Ferrone, Marcus; van Criekinge, Mark; Chang, Jose W; Bok, Robert; Park, Ilwoo; Reed, Galen; Carvajal, Lucas; Small, Eric J; Munster, Pamela; Weinberg, Vivian KScience translational medicine2013 Aug 14198ra10823946197
VirD: a virion display array for profiling functional membrane proteins.Hu, Shaohui; Feng, Yingzhu; Henson, Brandon; Wang, Bochu; Huang, Xiaofang; Li, Min; Desai, Prashant; Zhu, HengAnalytical chemistry2013 Sep 38046-5423941274
Integrated analysis of drug-induced gene expression profiles predicts novel hERG inhibitors.Babcock, Joseph J; Du, Fang; Xu, Kaiping; Wheelan, Sarah J; Li, MinPloS one2013e6951323936032
Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.Deng, Huayun; Sun, Haiyan; Fang, YeJournal of pharmacological and toxicological methods2013 Nov-Dec323-3323933114
Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide.Boodram, Sherry N; McCann, Lucas C; Organ, Michael G; Johnson, Philip EAnalytical biochemistry2013 Nov 15231-623928050
Rapid parallel flow cytometry assays of active GTPases using effector beads.Buranda, Tione; Basuray, Soumik; Swanson, Scarlett; Agola, Jacob; Bondu, Virginie; Wandinger-Ness, AngelaAnalytical biochemistry2013 Aug 6149-15723928044
Spiro Fused Diterpene-Indole Alkaloids from a Creek-Bottom-Derived Aspergillus terreus.Cai, Shengxin; Du, Lin; Gerea, Alexandra L; King, Jarrod B; You, Jianlan; Cichewicz, Robert HOrganic letters2013 Aug 164186-923924243
Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery.Ramadhar, Timothy R; Beemelmanns, Christine; Currie, Cameron R; Clardy, JonThe Journal of antibiotics2014 Jan53-823921819
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.Ramos-Hunter, Susan J; Engers, Darren W; Kaufmann, Kristian; Du, Yu; Lindsley, Craig W; Weaver, C David; Sulikowski, Gary ABioorganic & medicinal chemistry letters2013 Sep 155195-823916258
Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids.Montaser, Rana; Paul, Valerie J; Luesch, HendrikOrganic letters2013 Aug 164050-323915229
Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity.Gunawan, Steven; Hulme, ChristopherOrganic & biomolecular chemistry2013 Sep 286036-4623912086
A highly specific cell-based high-throughput screening assay for ligands of cyclic adenosine monophosphate receptor protein in gram-negative bacteria.Wang, Hongxia; Silva, Anisia J; Rasmussen, Lynn; White, E Lucile; Benitez, Jorge AAssay and drug development technologies2013 Jul382-723906348
A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.Du, Yuhong; Fu, Robert W; Lou, Bin; Zhao, Jing; Qui, Min; Khuri, Fadlo R; Fu, HaianAssay and drug development technologies2013 Jul367-8123906346
Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model.Grant, Sarah Schmidt; Kawate, Tomohiko; Nag, Partha P; Silvis, Melanie R; Gordon, Katherine; Stanley, Sarah A; Kazyanskaya, Edward; Nietupski, Raymond; Golas, Aaron; Fitzgerald, Michael; Cho, Sanghyun; Franzblau, Scott G; Hung, Deborah TACS chemical biology2013 Oct 182224-3423898841
A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene.Stallforth, Pierre; Brock, Debra A; Cantley, Alexandra M; Tian, Xiangjun; Queller, David C; Strassmann, Joan E; Clardy, JonProceedings of the National Academy of Sciences of the United States of America2013 Sep 314528-3323898207
NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41.Gochin, Miriam; Whitby, Landon R; Phillips, Aaron H; Boger, Dale LJournal of computer-aided molecular design2013 Jul569-8223893342
Emerging trends in the discovery of natural product antibacterials.Bologa, Cristian G; Ursu, Oleg; Oprea, Tudor I; Melancon 3rd, Charles E; Tegos, George PCurrent opinion in pharmacology2013 Jul 24NULL23890825
An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins.Gao, Xue; Jiang, Wei; Jimenez-Oses, Gonzalo; Choi, Moon Seok; Houk, Kendall N; Tang, Yi; Walsh, Christopher TChemistry & biology2013 Jul 25870-823890005
pCAP-based peptide substrates: The new tool in the box of tyrosine phosphatase assays.Stanford, Stephanie M; Krishnamurthy, Divya; Kulkarni, Rhushikesh A; Karver, Caitlin E; Bruenger, Eveline; Walker, Logan M; Ma, Chen-Ting; Chung, Thomas D Y; Sergienko, Eduard; Bottini, Nunzio; Barrios, Amy MMethods (San Diego, Calif.)2013 Jul 22NULL23886911
Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.Al-Mestarihi, Ahmad; Romo, Anthony; Liu, Hung-wen; Bachmann, Brian OJournal of the American Chemical Society2013 Aug 711457-6023885759
Analysis of High-Dimensional Structure-Activity Screening Datasets Using the Optimal Bit String Tree.Zhang, Ke; Hughes-Oliver, Jacqueline M; Young, S StanleyTechnometrics : a journal of statistics for the physical, chemical, and engineering sciences2013161-17323878407
Production of ýý-galactosylceramide by a prominent member of the human gut microbiota.Wieland Brown, Laura C; Penaranda, Cristina; Kashyap, Purna C; Williams, Brianna B; Clardy, Jon; Kronenberg, Mitchell; Sonnenburg, Justin L; Comstock, Laurie E; Bluestone, Jeffrey A; Fischbach, Michael APLoS biology2013 Jule100161023874157
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Santagata, Sandro; Mendillo, Marc L; Tang, Yun-chi; Subramanian, Aravind; Perley, Casey C; Roche, Stephane P; Wong, Bang; Narayan, Rajiv; Kwon, Hyoungtae; Koeva, Martina; Amon, Angelika; Golub, Todd R; Porco Jr, John A; Whitesell, Luke; Lindquist, SusanScience (New York, N.Y.)2013 Jul 19123830323869022
Novel diuretic targets.Denton, Jerod S; Pao, Alan C; Maduke, MerrittAmerican journal of physiology. Renal physiology2013 Oct 1F931-4223863472
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.Rahmouni, Souad; Delacroix, Laurence; Liu, Wallace H; Tautz, LutzMethods in molecular biology (Clifton, N.J.)2013241-7023860658
High-throughput screening for protein tyrosine phosphatase activity modulators.Tautz, Lutz; Sergienko, Eduard AMethods in molecular biology (Clifton, N.J.)2013223-4023860657
Protein tyrosine phosphatases: structure, function, and implication in human disease.Tautz, Lutz; Critton, David A; Grotegut, StefanMethods in molecular biology (Clifton, N.J.)2013179-22123860656
New activity assays for ENPP1 with physiological substrates ATP and ADP.Ma, Chen-Ting; Sergienko, Eduard AMethods in molecular biology (Clifton, N.J.)2013145-5423860653
Modulators of intestinal alkaline phosphatase.Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Sergienko, Eduard AMethods in molecular biology (Clifton, N.J.)2013135-4423860652
A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples.Sergienko, Eduard A; Sun, Qing; Ma, Chen-TingMethods in molecular biology (Clifton, N.J.)2013103-1323860649
Robotic implementation of assays: tissue-nonspecific alkaline phosphatase (TNAP) case study.Chung, Thomas D YMethods in molecular biology (Clifton, N.J.)201353-8423860647
A sphingosine 1-phosphate receptor 2 selective allosteric agonist.Satsu, Hideo; Schaeffer, Marie-Therese; Guerrero, Miguel; Saldana, Adrian; Eberhart, Christina; Hodder, Peter; Cayanan, Charmagne; Schurer, Stephan; Bhhatarai, Barun; Roberts, Ed; Rosen, Hugh; Brown, Steven JBioorganic & medicinal chemistry2013 Sep 15373-8223849205
Integrative chemical-biological read-across approach for chemical hazard classification.Low, Yen; Sedykh, Alexander; Fourches, Denis; Golbraikh, Alexander; Whelan, Maurice; Rusyn, Ivan; Tropsha, AlexanderChemical research in toxicology2013 Aug 191199-20823848138
Regulation of proteolysis by human deubiquitinating enzymes.Eletr, Ziad M; Wilkinson, Keith DBiochimica et biophysica acta2013 Jul 9NULL23845989
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.Wen, Wandong; Wu, Wenjun; Romaine, Ian M; Kaufmann, Kristian; Du, Yu; Sulikowski, Gary A; Weaver, C David; Lindsley, Craig WBioorganic & medicinal chemistry letters2013 Jun 20NULL23838260
Small-molecule procaspase activators identified using fluorescence polarization.Vickers, Chris J; Gonzalez-Paez, Gonzalo E; Umotoy, Jeffrey C; Cayanan-Garrett, Charmagne; Brown, Steven J; Wolan, Dennis WChembiochem : a European journal of chemical biology2013 Aug 191419-2223836614
Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae.Napper, Andrew D; Motlekar, Nuzhat; de Almeida, Rogerio Alves; Pavitt, Graham DCurrent protocols in chemical biology2011 Mar 14165323836585
Scaling and systems biology for integrating multiple organs-on-a-chip.Wikswo, John P; Curtis, Erica L; Eagleton, Zachary E; Evans, Brian C; Kole, Ayeeshik; Hofmeister, Lucas H; Matloff, William JLab on a chip2013 Aug 133496-51123828456
Identification of a ýý-ýý opioid receptor heteromer-biased agonist with antinociceptive activity.Gomes, Ivone; Fujita, Wakako; Gupta, Achla; Saldanha, Adrian S; Negri, Ana; Pinello, Christine E; Roberts, Edward; Filizola, Marta; Hodder, Peter; Devi, Lakshmi AProceedings of the National Academy of Sciences of the United States of America2013 Jul 1612072-723818586
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.Guo, Juan; Zhou, Yongjin J; Hillwig, Matthew L; Shen, Ye; Yang, Lei; Wang, Yajun; Zhang, Xianan; Liu, Wujun; Peters, Reuben J; Chen, Xiaoya; Zhao, Zongbao K; Huang, LuqiProceedings of the National Academy of Sciences of the United States of America2013 Jul 1612108-1323812755
PPAR*-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.Kim, S; Kiyosawa, N; Burgoon, L D; Chang, C C; Zacharewski, T RThe Journal of steroid biochemistry and molecular biology2013 Nov236-4723811191
Allokutzneria multivorans sp. nov., an actinomycete isolated from soil.Cao, Yan-Ru; Chen, Xiu; Jiang, Yi; Wang, Li-Song; Jiang, Cheng-LinInternational journal of systematic and evolutionary microbiology2013 Nov4254-823811139
Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas.Yang, Miao; Odelberg, Shannon J; Tong, Zongzhong; Li, Dean Y; Looper, Ryan ETetrahedron2013 Jul 85744-575023807819
Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond.Vatansever, Fatma; de Melo, Wanessa C M A; Avci, Pinar; Vecchio, Daniela; Sadasivam, Magesh; Gupta, Asheesh; Chandran, Rakkiyappan; Karimi, Mahdi; Parizotto, Nivaldo A; Yin, Rui; Tegos, George P; Hamblin, Michael RFEMS microbiology reviews2013 Nov955-8923802986
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.Li, Ping; Chen, Zhuxi; Xu, Haiyan; Sun, Haifeng; Li, Hao; Liu, Hong; Yang, Huaiyu; Gao, Zhaobing; Jiang, Hualiang; Li, MinCell research2013 Sep1106-1823797855
Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis.Wu, Yisheng; Wang, Qiang; Hillwig, Matthew L; Peters, Reuben JThe Biochemical journal2013 Jun 25NULL23795884
Characterisation of polymer shelled microbubbles in wall less flow phantom using high frequency ultrasound and video microscopy.Chitnis, P V; Lee, P; Dayton, P A; Mamou, J; Ketterling, J ABubble science engineering and technology2011 Nov 173-7823795208
A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.Zhao, Xiuli; Tang, Zongxiang; Zhang, Hongkang; Atianjoh, Fidelis E; Zhao, Jian-Yuan; Liang, Lingli; Wang, Wei; Guan, Xiaowei; Kao, Sheng-Chin; Tiwari, Vinod; Gao, Yong-Jing; Hoffman, Paul N; Cui, Hengmi; Li, Min; Dong, Xinzhong; Tao, Yuan-XiangNature neuroscience2013 Aug1024-3123792947
Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics.Wang, Hsin-Neng; Fales, Andrew M; Zaas, Aimee K; Woods, Christopher W; Burke, Thomas; Ginsburg, Geoffrey S; Vo-Dinh, TuanAnalytica chimica acta2013 Jul 5153-823790305
Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.Pinilla, Clemencia; Edwards, Bruce S; Appel, Jon R; Yates-Gibbins, Tina; Giulianotti, Marc A; Medina-Franco, Jose L; Young, Susan M; Santos, Radleigh G; Sklar, Larry A; Houghten, Richard AMolecular pharmacology2013 Sep314-2423788657
In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes.McAnally, Danielle; Vicchiarelli, Michael; Siddiquee, Khandaker; Smith, Layton HCurrent protocols in chemical biology2012 Dec 1299-30923788556
Profiling protein methylation with cofactor analog containing terminal alkyne functionality.Blum, Gil; Bothwell, Ian R; Islam, Kabirul; Luo, MinkuiCurrent protocols in chemical biology2013 Mar 167-8823788324
Development of highly selective casein kinase 1ýý/1ýý (CK1ýý/ýý) inhibitors with potent antiproliferative properties.Bibian, Mathieu; Rahaim, Ronald J; Choi, Jun Yong; Noguchi, Yoshihiko; Schurer, Stephan; Chen, Weimin; Nakanishi, Shima; Licht, Konstantin; Rosenberg, Laura H; Li, Lin; Feng, Yangbo; Cameron, Michael D; Duckett, Derek R; Cleveland, John L; Roush, William Bioorganic & medicinal chemistry letters2013 Aug 14374-8023787102
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.Yeung, J; Apopa, P L; Vesci, J; Stolla, M; Rai, G; Simeonov, A; Jadhav, A; Fernandez-Perez, P; Maloney, D J; Boutaud, O; Holman, T R; Holinstat, MThrombosis and haemostasis2013 Sep569-8123784669
RanGTP and CLASP1 cooperate to position the mitotic spindle.Bird, Stephen L; Heald, Rebecca; Weis, KarstenMolecular biology of the cell2013 Aug2506-1423783028
Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets.Young, Summer E; Duvernay, Matthew T; Schulte, Michael L; Lindsley, Craig W; Hamm, Heidi EPloS one2013e6552823776495
In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway.Wang, Rui; Mason, Daniel E; Choe, Keith P; Lewin, Alfred S; Peters, Eric C; Luesch, HendrikACS chemical biology2013 Aug 161764-7423773140
Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays.Landry, James P; Fei, Yiyan; Zhu, Xiangdong; Ke, Yaohuang; Yu, Guoliang; Lee, PierreAssay and drug development technologies2013 Jun326-3223772553
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.Xiao, Jingbo; Huang, Zaohua; Chen, Catherine Z; Agoulnik, Irina U; Southall, Noel; Hu, Xin; Jones, Raisa E; Ferrer, Marc; Zheng, Wei; Agoulnik, Alexander I; Marugan, Juan JNature communications2013195323764525
Various cyclization scaffolds by a truly Ugi 4-CR.Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, AlexanderOrganic & biomolecular chemistry2013 Jun 1323760036
Synthesis of spirocarbamate oxindoles via intramolecular trapping of a ýý-silyl carbocation by an N-Boc group.Shupe, Benjamin H; Allen, Emily E; MacDonald, Jacob P; Wilson, Sean O; Franz, Annaliese KOrganic letters2013 Jul 53218-2123758331
Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.Yu, Yi-Yun; Bi, Lei; Georg, Gunda IThe Journal of organic chemistry2013 Jun 216163-923750615
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.Ardecky, Robert J; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Gonzalez-Lopez, Marcos; Ganji, Santhi Reddy; Ravanan, Palaniyandi; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D PBioorganic & medicinal chemistry letters2013 Jul 154253-723743278
Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones.De, Subhasis; Chen, Lu; Zhang, Shuxing; Gilbertson, Scott RACS combinatorial science2013 Jul 8340-323742807
A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress.Wang, Hongxia; Zhang, Li; Silva, Anisia J; Benitez, Jorge AAntimicrobial agents and chemotherapy2013 Aug3950-923733460
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.Kaufmann, Kristian; Romaine, Ian; Days, Emily; Pascual, Conrado; Malik, Adam; Yang, Liya; Zou, Bende; Du, Yu; Sliwoski, Greg; Morrison, Ryan D; Denton, Jerod; Niswender, Colleen M; Daniels, J Scott; Sulikowski, Gary A; Xie, Xinmin Simon; Lindsley, Craig WACS chemical neuroscience2013 Sep 181278-8623730969
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.Floyd, Scott R; Pacold, Michael E; Huang, Qiuying; Clarke, Scott M; Lam, Fred C; Cannell, Ian G; Bryson, Bryan D; Rameseder, Jonathan; Lee, Michael J; Blake, Emily J; Fydrych, Anna; Ho, Richard; Greenberger, Benjamin A; Chen, Grace C; Maffa, Amanda; Del RNature2013 Jun 13246-5023728299
Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.Scott, Sarah A; Xiang, Yun; Mathews, Thomas P; Cho, Hyekyung P; Myers, David S; Armstrong, Michelle D; Tallman, Keri A; O'Reilly, Matthew C; Lindsley, Craig W; Brown, H AlexThe Journal of biological chemistry2013 Jul 1220477-8723723068
The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors.Santos, Radleigh G; Appel, Jon R; Giulianotti, Marc A; Edwards, Bruce S; Sklar, Larry A; Houghten, Richard A; Pinilla, ClemenciaMolecules (Basel, Switzerland)20136408-2423722730
Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip.Ngo, Hoan Thanh; Wang, Hsin-Neng; Fales, Andrew M; Vo-Dinh, TuanAnalytical chemistry2013 Jul 26378-8323718777
Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative Allosteric Modulator (NAM).Wenthur, Cody J; Morrison, Ryan; Felts, Andrew S; Smith, Katrina A; Engers, Julie L; Byers, Frank W; Daniels, J Scott; Emmitte, Kyle A; Conn, P Jeffrey; Lindsley, Craig WJournal of medicinal chemistry2013 Jun 275208-1223718281
Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry.Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, ChristopherOrganic letters2013 Jun 72738-4123718233
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.Harris, Michael T; Walker, Dawn M; Drew, Mark E; Mitchell, William G; Dao, Kevin; Schroeder, Chad E; Flaherty, Daniel P; Weiner, Warren S; Golden, Jennifer E; Morris, James CAntimicrobial agents and chemotherapy2013 Aug3731-723716053
Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.Rateb, Mostafa E; Yu, Zhiguo; Yan, Yijun; Yang, Dong; Huang, Tingting; Vodanovic-Jankovic, Sanja; Kron, Michael A; Shen, BenThe Journal of antibiotics2013 May 2923715040
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh; Zhu, Hao; Afantitis, Antreas; Mouchlis, Varnavas D; Melagraki, Georgia; Rusyn, Ivan; Tropsha, AlexanderToxicology and applied pharmacology2013 Oct 167-7623707773
Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.Medina-Franco, Jose L; Edwards, Bruce S; Pinilla, Clemencia; Appel, Jon R; Giulianotti, Marc A; Santos, Radleigh G; Yongye, Austin B; Sklar, Larry A; Houghten, Richard AJournal of chemical information and modeling2013 Jun 241475-8523705689
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David NThe Journal of biological chemistry2013 Jul 519949-5723703611
Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe Alkaloid Analogues.Granger, Brett A; Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen FACS combinatorial science2013 Jun 4NULL23697376
Predicting drug-induced QT prolongation effects using multi-view learning.Zhang, Jintao; Huan, JunIEEE transactions on nanobioscience2013 Sep206-1323694701
Inside job: ligand-receptor pharmacology beneath the plasma membrane.Babcock, Joseph J; Li, MinActa pharmacologica Sinica2013 Jul859-6923685953
Synthesis of a Library of "Lead-Like" ýý-Lactams by a One Pot, Four-Component Reaction.Martin, Kevin S; Di Maso, Michael J; Fettinger, James C; Shaw, Jared ThomasACS combinatorial science2013 May 17NULL23682712
Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology.Watson, Venita Gresham; Drake, Katherine M; Peng, Yu; Napper, Andrew DAssay and drug development technologies2013 May253-6823679849
Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.Lu, Jiuyi; Chen, Minyong; Ren, Xiu-Rong; Wang, Jiangbo; Lyerly, H Kim; Barak, Larry; Chen, WeiPloS one2013e6335323671675
Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine.Blum, Gil; Islam, Kabirul; Luo, MinkuiCurrent protocols in chemical biology2013 Mar 145-6623667794
Using Azido Analogue of S-Adenosyl-L-methionine for Bioorthogonal Profiling of Protein Methylation (BPPM).Blum, Gil; Islam, Kabirul; Luo, MinkuiCurrent protocols in chemical biology2013 Mar45-6623667794
Mechanism-based corrector combination restores ýýF508-CFTR folding and function.Okiyoneda, Tsukasa; Veit, Guido; Dekkers, Johanna F; Bagdany, Miklos; Soya, Naoto; Xu, Haijin; Roldan, Ariel; Verkman, Alan S; Kurth, Mark; Simon, Agnes; Hegedus, Tamas; Beekman, Jeffrey M; Lukacs, Gergely LNature chemical biology2013 Jul444-5423666117
New route to the ergoline skeleton via cyclization of 4-unsubstituted indoles.Burley, Scott D; Lam, Vicky V; Lakner, Frederick J; Bergdahl, B Mikael; Parker, Matthew AOrganic letters2013 Jun 72598-60023659323
A rapid membrane potential assay to monitor CFTR function and inhibition.Maitra, Rangan; Sivashanmugam, Perumal; Warner, KeithJournal of biomolecular screening2013 Oct1132-723653393
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.Xu, Wei; Chooi, Yit-Heng; Choi, Jin W; Li, Shuang; Vederas, John C; Da Silva, Nancy A; Tang, YiAngewandte Chemie (International ed. in English)2013 Jun 176472-523653178
Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.Zhou, Pingzheng; Yu, Haibo; Gu, Min; Nan, Fa-jun; Gao, Zhaobing; Li, MinProceedings of the National Academy of Sciences of the United States of America2013 May 218726-3123650395
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.Yu, Haibo; Lin, Zhihong; Mattmann, Margrith E; Zou, Beiyan; Terrenoire, Cecile; Zhang, Hongkang; Wu, Meng; McManus, Owen B; Kass, Robert S; Lindsley, Craig W; Hopkins, Corey R; Li, MinProceedings of the National Academy of Sciences of the United States of America2013 May 218732-723650380
Tricycles by a new ugi variation and pictet-spengler reaction in one pot.Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, AlexanderChemistry (Weinheim an der Bergstrasse, Germany)2013 Jun 178048-5223649922
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.Coombs, Thomas C; Tanega, Cordelle; Shen, Min; Wang, Jenna L; Auld, Douglas S; Gerritz, Samuel W; Schoenen, Frank J; Thomas, Craig J; Aube, JeffreyBioorganic & medicinal chemistry letters2013 Jun 153654-6123642479
High-Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor.Conn, P Michael; Smith, Emery; Hodder, Peter; Janovick, Jo Ann; Smithson, David CJournal of biomolecular screening2013 May 223640875
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Engers, Darren W; Frist, Audrey Y; Lindsley, Craig W; Hong, Charles C; Hopkins, Corey RBioorganic & medicinal chemistry letters2013 Jun 13248-5223639540
An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans.Leung, Chi K; Wang, Ying; Malany, Siobhan; Deonarine, Andrew; Nguyen, Kevin; Vasile, Stefan; Choe, Keith PPloS one2013e6216623637990
Cheminformatics aspects of high throughput screening: from robots to models: symposium summary.Jane Tseng, Y; Martin, Eric; G Bologa, Cristian; Shelat, Anang AJournal of computer-aided molecular design2013 May443-5323636795
Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig WTetrahedron letters2013 May 12231-223423606772
A small molecule inhibitor of redox-regulated protein translocation into mitochondria.Dabir, Deepa V; Hasson, Samuel A; Setoguchi, Kiyoko; Johnson, Meghan E; Wongkongkathep, Piriya; Douglas, Colin J; Zimmerman, Johannes; Damoiseaux, Robert; Teitell, Michael A; Koehler, Carla MDevelopmental cell2013 Apr 1581-9223597483
Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor.Cheng, Bokun; Cao, Shugeng; Vasquez, Victor; Annamalai, Thirunavukkarasu; Tamayo-Castillo, Giselle; Clardy, Jon; Tse-Dinh, Yuk-ChingPloS one2013e6077023593306
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening.Thomas, Pei W; Spicer, Timothy; Cammarata, Michael; Brodbelt, Jennifer S; Hodder, Peter; Fast, WalterBioorganic & medicinal chemistry2013 Jun 13138-4623591260
A small molecule inhibitor of fungal histone acetyltransferase Rtt109.Lopes da Rosa, Jessica; Bajaj, Vineeta; Spoonamore, James; Kaufman, Paul DBioorganic & medicinal chemistry letters2013 May 152853-923587423
An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.Mulrooney, Carol A; Lahr, David L; Quintin, Michael J; Youngsaye, Willmen; Moccia, Dennis; Asiedu, Jacob K; Mulligan, Evan L; Akella, Lakshmi B; Marcaurelle, Lisa A; Montgomery, Philip; Bittker, Joshua A; Clemons, Paul A; Brudz, Stephen; Dandapani, SivaraJournal of computer-aided molecular design2013 May455-6823585218
Neural progenitor cells labeling with microbubble contrast agent for ultrasound imaging in vivo.Cui, Wenjin; Tavri, Sidhartha; Benchimol, Michael J; Itani, Malak; Olson, Emilia S; Zhang, Hong; Decyk, Marika; Ramirez, Rosemarie G; Barback, Christopher V; Kono, Yuko; Mattrey, Robert FBiomaterials2013 Jul4926-3523578557
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents.Karapetyan, Yervand Eduard; Sferrazza, Gian Franco; Zhou, Minghai; Ottenberg, Gregory; Spicer, Timothy; Chase, Peter; Fallahi, Mohammad; Hodder, Peter; Weissmann, Charles; Lasmezas, Corinne IdaProceedings of the National Academy of Sciences of the United States of America2013 Apr 237044-923576755
The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding.Zhu, Xiang-Wei; Sedykh, Alexander; Zhu, Hao; Liu, Shu-Shen; Tropsha, AlexanderPharmaceutical research2013 Jul1790-823568522
Discovery of BRM Targeted Therapies: Novel Reactivation of an Anti-cancer Gene.Gramling, Sarah; Reisman, DavidLetters in drug design & discovery2011 Jan 193-9923565070
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.Hu, Longqin; Magesh, Sadagopan; Chen, Lin; Wang, Lili; Lewis, Timothy A; Chen, Yu; Khodier, Carol; Inoyama, Daigo; Beamer, Lesa J; Emge, Thomas J; Shen, Jian; Kerrigan, John E; Kong, Ah-Ng Tony; Dandapani, Sivaraman; Palmer, Michelle; Schreiber, Stuart L;Bioorganic & medicinal chemistry letters2013 May 153039-4323562243
Discovery of ML326: The first sub-micromolar, selective M5 PAM.Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Scott Daniels, J; Jeffrey Conn, P; Wood, Michael R; Lindsley, Craig WBioorganic & medicinal chemistry letters2013 May 152996-300023562060
Ugi/Robinson-Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles.Shaw, Arthur Y; Xu, Zhigang; Hulme, ChristopherTetrahedron letters2012 Apr 111998-200023559684
Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones.Coffman, Keith C; Palazzo, Teresa A; Hartley, Timothy P; Fettinger, James C; Tantillo, Dean J; Kurth, Mark JOrganic letters2013 Apr 192062-523557405
Synthesis and Characterization of Germanium Coordination Compounds for Production of Germanium Nanomaterials.Boyle, Timothy J; Tribby, Louis J; Ottley, Leigh Anna M; Han, Sang MEuropean journal of inorganic chemistry2009 Dec 15550-556023555180
Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol.Hutt, Oliver E; Doan, Trinh L; Georg, Gunda IOrganic letters2013 Apr 51602-523530630
Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C-H activation.Yu, Yi-Yun; Georg, Gunda IChemical communications (Cambridge, England)2013 May 73694-623529083
Sphingosine-1-phosphate and its receptors: structure, signaling, and influence.Rosen, Hugh; Stevens, Raymond C; Hanson, Michael; Roberts, Edward; Oldstone, Michael B AAnnual review of biochemistry2013637-6223527695
Intermolecular C-O Addition of Carboxylic Acids to Arynes: Synthesis of o-Hydroxyaryl Ketones, Xanthones, 4-Chromanones, and Flavones.Dubrovskiy, Anton V; Larock, Richard CTetrahedron2013 Apr 12789-279823520410
Solution-phase parallel synthesis of a multisubstituted cyclic imidate library.Mehta, Saurabh; Waldo, Jesse P; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard CACS combinatorial science2013 May 13247-5423514214
Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.Dranchak P, MacArthur R, Guha R, Zuercher WJ, Drewry DH, Auld DS, Inglese J.PLoS One2013 Mar 7e5788823505445
A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families.De Moliner, Fabio; Hulme, ChristopherTetrahedron letters2012 Oct 245787-579023504533
Histological image classification using biologically interpretable shape-based features.Kothari, Sonal; Phan, John H; Young, Andrew N; Wang, May DBMC medical imaging2013923497380
Applications of fiber-optics-based nanosensors to drug discovery.Vo-Dinh, Tuan; Scaffidi, Jonathan; Gregas, Molly; Zhang, Yan; Seewaldt, VictoriaExpert opinion on drug discovery2009 Aug889-90023496274
Molecular sentinel-on-chip for SERS-based biosensing.Wang, Hsin-Neng; Dhawan, Anuj; Du, Yan; Batchelor, Dale; Leonard, Donovan N; Misra, Veena; Vo-Dinh, TuanPhysical chemistry chemical physics : PCCP2013 Apr 286008-1523493773
High-Throughput RT-PCR for small-molecule screening assays.Bittker, Joshua ACurrent protocols in chemical biology2012 Mar 149-6323487248
Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay.Cryan, Lorna M; Habeshian, Kaiane A; Caldwell, Thomas P; Morris, Meredith T; Ackroyd, P Christine; Christensen, Kenneth A; Rogers, Michael SJournal of biomolecular screening2013 Jul714-2523479355
Bioluminescent assays for cytochrome P450 enzymes.Auld DS, Veith H, Cali JJ.Methods Mol Biol20131-923475663
Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes.Dubrovskiy, Anton V; Jain, Prashi; Shi, Feng; Lushington, Gerald H; Santini, Conrad; Porubsky, Patrick; Larock, Richard CACS combinatorial science2013 Apr 8193-20123472819
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.Strouse, J Jacob; Ivnitski-Steele, Irena; Waller, Anna; Young, Susan M; Perez, Dominique; Evangelisti, Annette M; Ursu, Oleg; Bologa, Cristian G; Carter, Mark B; Salas, Virginia M; Tegos, George; Larson, Richard S; Oprea, Tudor I; Edwards, Bruce S; Sklar,Analytical biochemistry2013 Jun 177-8723470221
The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide.Cabarcas SM, Sun L, Mathews L, Thomas S, Zhang X, Farrar WL.Pancreas2013 Jul861-7023462327
Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules.Sun, Hongmao; Veith, Henrike; Xia, Menghang; Austin, Christopher P; Tice, Raymond R; Huang, RuiliMolecular informatics2012 Nov 1783-79223459712
Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.Chen, Haijun; Ding, Chunyong; Wild, Christopher; Liu, Huiling; Wang, Tianzhi; White, Mark A; Cheng, Xiaodong; Zhou, JiaTetrahedron letters2013 Mar 201546-154923459418
A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems.Senter, Timothy J; Schulte, Michael L; Konkol, Leah C; Wadzinski, Tyler E; Lindsley, Craig WTetrahedron letters2013 Mar 271645-164823459400
hERG channel function: beyond long QT.Babcock, Joseph J; Li, MinActa pharmacologica Sinica2013 Mar329-3523459091
Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model.Chibebe Junior, Jose; Fuchs, Beth B; Sabino, Caetano P; Junqueira, Juliana C; Jorge, Antonio O C; Ribeiro, Martha S; Gilmore, Michael S; Rice, Louis B; Tegos, George P; Hamblin, Michael R; Mylonakis, EleftheriosPloS one2013e5592623457486
EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.Jiang, Wei; Cacho, Ralph A; Chiou, Grace; Garg, Neil K; Tang, Yi; Walsh, Christopher TJournal of the American Chemical Society2013 Mar 204457-6623451921
High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe.McCallum, Megan M; Nandhikonda, Premchendar; Temmer, Jonathan J; Eyermann, Charles; Simeonov, Anton; Jadhav, Ajit; Yasgar, Adam; Maloney, David; Arnold, Alexander LeggyJournal of biomolecular screening2013 Feb 2723446699
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.O'Reilly, Matthew C; Scott, Sarah A; Brown, Kyle A; Oguin 3rd, Thomas H; Thomas, Paul G; Daniels, J Scott; Morrison, Ryan; Brown, H Alex; Lindsley, Craig WJournal of medicinal chemistry2013 Mar 282695-923445448
Probing the metabotropic glutamate receptor 5 (mGluýýý) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Gregory, Karen J; Nguyen, Elizabeth D; Reiff, Sean D; Squire, Emma F; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, P JeffreyMolecular pharmacology2013 May991-100623444015
Developing irreversible inhibitors of the protein kinase cysteinome.Liu, Qingsong; Sabnis, Yogesh; Zhao, Zheng; Zhang, Tinghu; Buhrlage, Sara J; Jones, Lyn H; Gray, Nathanael SChemistry & biology2013 Feb 21146-5923438744
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.Welsbie, Derek S; Yang, Zhiyong; Ge, Yan; Mitchell, Katherine L; Zhou, Xinrong; Martin, Scott E; Berlinicke, Cynthia A; Hackler Jr, Laszlo; Fuller, John; Fu, Jie; Cao, Li-hui; Han, Bing; Auld, Douglas; Xue, Tian; Hirai, Syu-ichi; Germain, Lucie; Simard-Bisson, Caroline; Blouin, Richard; Nguyen, Judy V; Davis, Chung-ha O; Enke, Raymond A; Boye, Sanford L; Merbs, Shannath L; Marsh-Armstrong, Nicholas; Hauswirth, William W; DiAntonio, Aaron; Nickells, Robert W; Inglese, James; Hanes, Justin; Yau, King-Wai; Quigley, Harry A; Zack, Donald JProceedings of the National Academy of Sciences of the United States of America2013 Mar 54045-5023431148
Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.Huang, Gang; Chen, Huabing; Dong, Ying; Luo, Xiuquan; Yu, Haijun; Moore, Zachary; Bey, Erik A; Boothman, David A; Gao, JinmingTheranostics2013116-2623423156
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael RBioorganic & medicinal chemistry letters2013 Mar 151860-423416001
Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders.Gregory, Karen J; Noetzel, Meredith J; Niswender, Colleen MProgress in molecular biology and translational science201361-12123415092
Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Klein, Michael T; Vinson, Paige N; Niswender, Colleen MProgress in molecular biology and translational science20131-5923415091
Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived claisen rearrangements.McIntosh, John A; Lin, Zhenjian; Tianero, Ma Diarey B; Schmidt, Eric WACS chemical biology2013 May 17877-8323411099
Synthesis and activity of biomimetic biofilm disruptors.Bottcher, Thomas; Kolodkin-Gal, Ilana; Kolter, Roberto; Losick, Richard; Clardy, JonJournal of the American Chemical Society2013 Feb 272927-3023406351
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.Germain, Andrew R; Carmody, Leigh C; Nag, Partha P; Morgan, Barbara; Verplank, Lynn; Fernandez, Cristina; Donckele, Etienne; Feng, Yuxiong; Perez, Jose R; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric S; Gupta, Piyush B; Schreiber, Stuart L; Munoz,Bioorganic & medicinal chemistry letters2013 Mar 151834-823403082
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.Sivan G, Martin SE, Myers TG, Buehler E, Szymczyk KH, Ormanoglu P, Moss B.Proc Natl Acad Sci U S A2013 Feb 263519-2423401514
A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase.Chen CZ, Southall N, Galkin A, Lim K, Marugan JJ, Kulakova L, Shinn P, van Leer D, Zheng W, Herzberg O.Curr Chem Genomics201293-10223400734
Parallel solution-phase synthesis of an adenosine antibiotic analog library.Moukha-chafiq, Omar; Reynolds, Robert CACS combinatorial science2013 Mar 11147-5223398694
An end to the myth: there is no drug development pipeline.Baxter K, Horn E, Gal-Edd N, Zonno K, O'Leary J, Terry PF, Terry SF.Sci Transl Med2013 Feb 65(171)23390245
Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells.Sherman, Sean P; Pyle, April DPloS one2013e5494823383009
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.Hong, Lin; Kenney, S Ray; Phillips, Genevieve K; Simpson, Denise; Schroeder, Chad E; Noth, Julica; Romero, Elsa; Swanson, Scarlett; Waller, Anna; Strouse, J Jacob; Carter, Mark; Chigaev, Alexandre; Ursu, Oleg; Oprea, Tudor; Hjelle, Brian; Golden, JenniferThe Journal of biological chemistry2013 Mar 228531-4323382385
High-throughput screening for small-molecule modulators of inward rectifier potassium channels.Raphemot, Rene; Weaver, C David; Denton, Jerod SJournal of visualized experiments : JoVE201323381507
Antibody therapeutics targeting ion channels: are we there yet?Sun, Han; Li, MinActa pharmacologica Sinica2013 Feb199-20423381110
Engineering challenges for instrumenting and controlling integrated organ-on-chip systems.Wikswo, John P; Block 3rd, Frank E; Cliffel, David E; Goodwin, Cody R; Marasco, Christina C; Markov, Dmitry A; McLean, David L; McLean, John A; McKenzie, Jennifer R; Reiserer, Ronald S; Samson, Philip C; Schaffer, David K; Seale, Kevin T; Sherrod, Stacy DIEEE transactions on bio-medical engineering2013 Mar682-9023380852
Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).Zak, Krzysztof; Pecak, Aleksandra; Rys, Barbara; Wladyka, Benedykt; Domling, Alexander; Weber, Lutz; Holak, Tad A; Dubin, GrzegorzExpert opinion on therapeutic patents2013 Apr425-4823374098
Feasibility of multiplex quantum dot stain using primary antibodies from four distinct host animals.Tran, Jonathan K; Hubbard, Elena N; Stokes, Todd H; Moffitt, Richard A; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20126576-923367436
Scale normalization of histopathological images for batch invariant cancer diagnostic models.Kothari, Sonal; Phan, John H; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20124406-923366904
Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines.Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J.RNA Biol2013 Feb287-30023353574
Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Emert-Sedlak, Lori A; Narute, Purushottam; Shu, Sherry T; Poe, Jerrod A; Shi, Haibin; Yanamala, Naveena; Alvarado, John Jeff; Lazo, John S; Yeh, Joanne I; Johnston, Paul A; Smithgall, Thomas EChemistry & biology2013 Jan 2482-9123352142
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanad Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Chemistry & biology2013 Jan 2455-6223352139
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanad Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Jadhav, Ajit; Gileadi, Opher; Maloney, David J; Simeonov, Anton; Hickson, Ian DChemistry & biology2013 Jan 2455-6223352139
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.Salvador, Lilibeth A; Taori, Kanchan; Biggs, Jason S; Jakoncic, Jean; Ostrov, David A; Paul, Valerie J; Luesch, HendrikJournal of medicinal chemistry2013 Feb 141276-9023350733
Effect of virulence factors on the photodynamic inactivation of Cryptococcus neoformans.Prates, Renato A; Fuchs, Beth Burgwyn; Mizuno, Kazue; Naqvi, Qurat; Kato, Ilka T; Ribeiro, Martha S; Mylonakis, Eleftherios; Tegos, George P; Hamblin, Michael RPloS one2013e5438723349872
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High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model.Titus SA, Southall N, Marugan J, Austin CP, Zheng W.Curr Chem Genomics201279-8623346268
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Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR 3rd, Wooge W, Tong W, Dix D.ALTEX201351-623338806
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Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin.Haynes, Stuart W; Gao, Xue; Tang, Yi; Walsh, Christopher TACS chemical biology2013 Apr 19741-823330675
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.Davis, Mindy I; Sasaki, Atsuo T; Shen, Min; Emerling, Brooke M; Thorne, Natasha; Michael, Sam; Pragani, Rajan; Boxer, Matthew; Sumita, Kazutaka; Takeuchi, Koh; Auld, Douglas S; Li, Zhuyin; Cantley, Lewis C; Simeonov, AntonPloS one2013e5412723326584
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.Vamos, Mitchell; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Mace, Peter D; Snipas, Scott J; Gonzalez, Monica L; Ganji, Santhi Reddy; Ardecky, Robert J; Riedl, Stefan J; Salvesen, Guy S; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D PACS chemical biology2013 Apr 19725-3223323685
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.Chou, Tsui-Fen; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Deshaies, Raymond JChemMedChem2013 Feb297-31223316025
Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride.Long Y, Lin Z, Xia M, Zheng W, Li Z.Toxicol Appl Pharmacol2013 Mar 1155-6623313619
High-throughput flow cytometry compatible biosensor based on fluorogen activating protein technology.Wu, Yang; Tapia, Phillip H; Fisher, Gregory W; Waggoner, Alan S; Jarvik, Jonathan; Sklar, Larry ACytometry. Part A : the journal of the International Society for Analytical Cytology2013 Feb220-623303704
Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.Liang, Yu; Vogel, Jodi L; Arbuckle, Jesse H; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Maloney, David J; Kristie, Thomas MScience translational medicine2013 Jan 9167ra523303604
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A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I; Ananthan, Subramaniam; White, E Lucile; Jia, Fuli; Jonsson, Colleen B; Severson, William EVirology journal20131923302182
Structural separations by ion mobility-MS for glycomics and glycoproteomics.Fenn, Larissa S; McLean, John AMethods in molecular biology (Clifton, N.J.)2013171-9423296531
Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.Hu, Xin; Vujanac, Milos; Southall, Noel; Stebbins, C ErecBioorganic & medicinal chemistry letters2013 Feb 151056-6223294700
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression.Bar-Shir, Amnon; Liu, Guanshu; Liang, Yajie; Yadav, Nirbhay N; McMahon, Michael T; Walczak, Piotr; Nimmagadda, Sridhar; Pomper, Martin G; Tallman, Keri A; Greenberg, Marc M; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf AJournal of the American Chemical Society2013 Jan 301617-2423289583
[Diversity and bioactivity of culturable actinobacteria from animal feces].Jiang, Yi; Cao, Yanru; Han, Li; Jin, Rongxian; Zheng, Dan; He, Wenxiang; Li, Youlong; Huang, XueshiWei sheng wu xue bao = Acta microbiologica Sinica2012 Oct 41282-923289327
SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.Guerrero, Miguel; Urbano, Mariangela; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2013 Feb 1614-923287738
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Chen, Haijun; Tsalkova, Tamara; Chepurny, Oleg G; Mei, Fang C; Holz, George G; Cheng, Xiaodong; Zhou, JiaJournal of medicinal chemistry2013 Feb 14952-6223286832
Microbial metabolic exchange in 3D.Watrous, Jeramie D; Phelan, Vanessa V; Hsu, Cheng-Chih; Moree, Wilna J; Duggan, Brendan M; Alexandrov, Theodore; Dorrestein, Pieter CThe ISME journal2013 Apr770-8023283018
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.Duveau, Damien Y; Hu, Xin; Walsh, Martin J; Shukla, Suneet; Skoumbourdis, Amanda P; Boxer, Matthew B; Ambudkar, Suresh V; Shen, Min; Thomas, Craig JBioorganic & medicinal chemistry letters2013 Feb 1682-623273517
Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions.Sedykh, Alexander; Fourches, Denis; Duan, Jianmin; Hucke, Oliver; Garneau, Michel; Zhu, Hao; Bonneau, Pierre; Tropsha, AlexanderPharmaceutical research2013 Apr996-100723269503
Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling.Nguyen, Huy H; Kurth, Mark JOrganic letters2013 Jan 18362-523268775
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).Nagano, Joseph M G; Hsu, Ku-Lung; Whitby, Landon R; Niphakis, Micah J; Speers, Anna E; Brown, Steven J; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter; Srinivasan, Prabhavathi; Gonzalez, Tara D; Rosen, Hugh; Bahnson, Brian J; CraBioorganic & medicinal chemistry letters2013 Feb 1839-4323260346
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.Digby, Gregory J; Utley, Thomas J; Lamsal, Atin; Sevel, Christian; Sheffler, Douglas J; Lebois, Evan P; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Lindsley, Craig W; Conn, P JeffreyACS chemical neuroscience2012 Dec 191025-3623259038
Adapting human pluripotent stem cells to high-throughput and high-content screening.Desbordes, Sabrina C; Studer, LorenzNature protocols2013 Jan111-3023257981
Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.Zhang, Liying; Fourches, Denis; Sedykh, Alexander; Zhu, Hao; Golbraikh, Alexander; Ekins, Sean; Clark, Julie; Connelly, Michele C; Sigal, Martina; Hodges, Dena; Guiguemde, Armand; Guy, R Kiplin; Tropsha, AlexanderJournal of chemical information and modeling2013 Feb 25475-9223252936
C911: A bench-level control for sequence specific siRNA off-target effects.Buehler E, Chen YC, Martin S.PLoS One2012e5194223251657
Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants.Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, ZhaobingPloS one2012e5182023251633
Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.Chandler, Josephine R; Truong, Thao T; Silva, Patricia M; Seyedsayamdost, Mohammad R; Carr, Gavin; Radey, Matthew; Jacobs, Michael A; Sims, Elizabeth H; Clardy, Jon; Greenberg, E PetermBio201223249812
RS-WebPredictor: a server for predicting CYP-mediated sites of metabolism on drug-like molecules.Zaretzki, Jed; Bergeron, Charles; Huang, Tao-wei; Rydberg, Patrik; Swamidass, S Joshua; Breneman, Curt MBioinformatics (Oxford, England)2013 Feb 15497-823242264
Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.Guo, Yirui; Partch, Carrie L; Key, Jason; Card, Paul B; Pashkov, Victor; Patel, Anjana; Bruick, Richard K; Wurdak, Heiko; Gardner, Kevin HACS chemical biology2013 Mar 15626-3523240775
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael RBioorganic & medicinal chemistry letters2013 Jan 15412-623237839
Small molecule amides as potent ROR-ýý selective modulators.Khan, Pasha M; El-Gendy, Bahaa El-Dien M; Kumar, Naresh; Garcia-Ordonez, Ruben; Lin, Li; Ruiz, Claudia H; Cameron, Michael D; Griffin, Patrick R; Kamenecka, Theodore MBioorganic & medicinal chemistry letters2013 Jan 15532-623232056
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL prJacobs, Jon; Grum-Tokars, Valerie; Zhou, Ya; Turlington, Mark; Saldanha, S Adrian; Chase, Peter; Eggler, Aimee; Dawson, Eric S; Baez-Santos, Yahira M; Tomar, Sakshi; Mielech, Anna M; Baker, Susan C; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew; StaufJournal of medicinal chemistry2013 Jan 24534-4623231439
Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.Oldstone, Michael B A; Teijaro, John R; Walsh, Kevin B; Rosen, HughVirology2013 Jan 592-10123217619
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.Johnson, Barry C; Pauly, Gary T; Rai, Ganesha; Patel, Disha; Bauman, Joseph D; Baker, Heather L; Das, Kalyan; Schneider, Joel P; Maloney, David J; Arnold, Eddy; Thomas, Craig J; Hughes, Stephen HRetrovirology20129923217210
Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay.Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI.J Biomol Screen2013 Jul670-723212924
A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.Dobri, Nicoleta; Qin, Qiong; Kong, Jian; Yamamoto, Kazunori; Liu, Zhao; Moiseyev, Gennadiy; Ma, Jian-Xing; Allikmets, Rando; Sparrow, Janet R; Petrukhin, KonstantinInvestigative ophthalmology & visual science2013 Jan85-9523211825
A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().Mott, Bryan T; Cheng, Ken Chih-Chien; Guha, Rajarshi; Kommer, Valerie P; Williams, David L; Vermeire, Jon J; Cappello, Michael; Maloney, David J; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Inglese, James; Posner, Gary H; Thomas, Craig JMedChemComm2012 Dec1505-151123205265
Nonomuraea solani sp. nov., an actinomycete isolated from eggplant root (Solanum melongena L.).Wang, Xiangjing; Zhao, Junwei; Liu, Chongxi; Wang, Jidong; Shen, Yue; Jia, Feiyu; Wang, Liang; Zhang, Ji; Yu, Chao; Xiang, WenshengInternational journal of systematic and evolutionary microbiology2013 Jul2418-2323203622
Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease.Lu, Bin; Lee, Jae; Nie, Xiaobo; Li, Min; Morozov, Yaroslav I; Venkatesh, Sundararajan; Bogenhagen, Daniel F; Temiakov, Dmitry; Suzuki, Carolyn KMolecular cell2013 Jan 10121-3223201127
Further exploration of Mýýý allosteric agonists: subtle structural changes abolish Mýýý allosteric agonism and result in pan-mAChR orthosteric antagonism.Sheffler, Douglas J; Sevel, Christian; Le, Uyen; Lovell, Kimberly M; Tarr, James C; Carrington, Sheridan J S; Cho, Hyekyung P; Digby, Gregory J; Niswender, Colleen M; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Lindsley, Craig WBioorganic & medicinal chemistry letters2013 Jan 1223-723200253
Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection.Yuan, Hsiangkuo; Liu, Yang; Fales, Andrew M; Li, You Leo; Liu, Jesse; Vo-Dinh, TuanAnalytical chemistry2013 Jan 2208-1223194068
High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.McCoy, Eric S; Lea, Wendy A; Mott, Bryan T; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Zylka, Mark JJournal of biomolecular screening2013 Apr481-923190738
Bimodal behavior and isobestic transition pathway in surface plasmon resonance sensing.Dhawan, Anuj; Canva, Michael; Vo-Dinh, TuanOptics express2012 Oct 823630-4223188328
Genome streamlining and chemical defense in a coral reef symbiosis.Kwan, Jason C; Donia, Mohamed S; Han, Andrew W; Hirose, Euichi; Haygood, Margo G; Schmidt, Eric WProceedings of the National Academy of Sciences of the United States of America2012 Dec 1120655-6023185008
The Role of Phosphatases in the Initiation of Skeletal Mineralization.Millan, Jose LuisCalcified tissue international2012 Nov 2723183786
Selenium dioxide-mediated synthesis of ýý-ketoamides from arylglyoxals and secondary amines.Shaw, Arthur Y; Denning, Christine R; Hulme, ChristopherTetrahedron letters2012 Aug 84151-415323180891
Discovery of a selective Mýýý positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.Le, Uyen; Melancon, Bruce J; Bridges, Thomas M; Vinson, Paige N; Utley, Thomas J; Lamsal, Atin; Rodriguez, Alice L; Venable, Daryl; Sheffler, Douglas J; Jones, Carrie K; Blobaum, Anna L; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Niswender, ColleBioorganic & medicinal chemistry letters2013 Jan 1346-5023177787
Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.Tarr, James C; Turlington, Mark L; Reid, Paul R; Utley, Thomas J; Sheffler, Douglas J; Cho, Hyekyung P; Klar, Rebecca; Pancani, Tristano; Klein, Michael T; Bridges, Thomas M; Morrison, Ryan D; Blobaum, Anna L; Xiang, Zixui; Daniels, J Scott; Niswender, CoACS chemical neuroscience2012 Nov 21884-9523173069
The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP.Pultz, Ingrid Swanson; Christen, Matthias; Kulasekara, Hemantha Don; Kennard, Andrew; Kulasekara, Bridget; Miller, Samuel IMolecular microbiology2012 Dec1424-4023163901
Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.Florian, Amy E; Lepensky, Christopher K; Kwon, Ohyun; Haynes, Mark K; Sklar, Larry A; Zweifach, AdamJournal of biomolecular screening2013 Apr420-923160568
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.Bauer, Renato A; Wenderski, Todd A; Tan, Derek SNature chemical biology2013 Jan21-923160003
Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.Lee, Gabsang; Ramirez, Christina N; Kim, Hyesoo; Zeltner, Nadja; Liu, Becky; Radu, Constantin; Bhinder, Bhavneet; Kim, Yong Jun; Choi, In Young; Mukherjee-Clavin, Bipasha; Djaballah, Hakim; Studer, LorenzNature biotechnology2012 Dec1244-823159879
Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds.Huang, Yijun; Khoury, Kareem; Chanas, Tyler; Domling, AlexanderOrganic letters2012 Dec 75916-923157402
Semitransparent nanostructured films for imaging mass spectrometry and optical microscopy.Forsythe, Jay G; Broussard, Joshua A; Lawrie, Jenifer L; Kliman, Michal; Jiao, Yang; Weiss, Sharon M; Webb, Donna J; McLean, John AAnalytical chemistry2012 Dec 1810665-7023146026
Marine cyanobacterial fatty acid amides acting on cannabinoid receptors.Montaser, Rana; Paul, Valerie J; Luesch, HendrikChembiochem : a European journal of chemical biology2012 Dec 212676-8123143757
Discovery and SAR of a novel series of non-MPEP site mGluýýý PAMs based on an aryl glycine sulfonamide scaffold.Rodriguez, Alice L; Zhou, Ya; Williams, Richard; David Weaver, C; Vinson, Paige N; Dawson, Eric S; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolome, Jose M; Macdonald, Gregor J; Scott Daniels, J; Niswender, Colleen M; Jones, Carrie K; JeffreyBioorganic & medicinal chemistry letters2012 Dec 157388-9223142615
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Rook, Jerri M; Noetzel, Meredith J; Pouliot, Wendy A; Bridges, Thomas M; Vinson, Paige N; Cho, Hyekyung P; Zhou, Ya; Gogliotti, Rocco D; Manka, Jason T; Gregory, Karen J; Stauffer, Shaun R; Dudek, F Edward; Xiang, Zixiu; Niswender, Colleen M; Daniels, J SBiological psychiatry2013 Mar 15501-923140665
Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles.Avila, Belem; El-Dakdouki, Mohammad H; Nazer, Musa Z; Harrison, Jason G; Tantillo, Dean J; Haddadin, Makhluf J; Kurth, Mark JTetrahedron letters2012 Nov 286475-647823139435
A high-throughput screening assay using Krabbe disease patient cells.Ribbens, Jameson; Whiteley, Grace; Furuya, Hirokazu; Southall, Noel; Hu, Xin; Marugan, Juan; Ferrer, Marc; Maegawa, Gustavo H BAnalytical biochemistry2013 Mar 115-2523138179
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ.Antimicrob Agents Chemother2013 Jan425-3523129054
Antimicrobial photodynamic inactivation inhibits Candida albicans virulence factors and reduces in vivo pathogenicity.Kato, Ilka Tiemy; Prates, Renato Araujo; Sabino, Caetano Padial; Fuchs, Beth Burgwyn; Tegos, George P; Mylonakis, Eleftherios; Hamblin, Michael R; Ribeiro, Martha SimoesAntimicrobial agents and chemotherapy2013 Jan445-5123129051
Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011).Deng, Xianming; Choi, Hwan Geun; Buhrlage, Sara J; Gray, Nathanael SExpert opinion on therapeutic patents2012 Dec1415-2623126385
Regio- and stereoselective synthesis of cyclic imidates via electrophilic cyclization of 2-(1-alkynyl)benzamides. A correction.Mehta, Saurabh; Yao, Tuanli; Larock, Richard CThe Journal of organic chemistry2012 Dec 710938-4423110553
A survey of quantitative descriptions of molecular structure.Guha R, Willighagen E.Curr Top Med Chem20121946-5623110530
Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.Dorjsuren, Dorjbal; Kim, Daemyung; Vyjayanti, Vaddadi N; Maloney, David J; Jadhav, Ajit; Wilson 3rd, David M; Simeonov, AntonPloS one2012e4797423110144
In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie LCancer chemotherapy and pharmacology2013 Feb331-4423108699
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DAGLýý inhibition perturbs a lipid network involved in macrophage inflammatory responses.Hsu, Ku-Lung; Tsuboi, Katsunori; Adibekian, Alexander; Pugh, Holly; Masuda, Kim; Cravatt, Benjamin FNature chemical biology2012 Dec999-100723103940
In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3.Qin, Qiong; Knapinska, Anna; Dobri, Nicoleta; Madoux, Franck; Chase, Peter; Hodder, Peter; Petrukhin, KonstantinJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2013 Apr298-30923098562
Compact quantum dots for single-molecule imaging.Smith, Andrew M; Nie, ShumingJournal of visualized experiments : JoVE2012NULL23093375
The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles.Haddadin, Makhluf J; Conrad, Wayne E; Kurth, Mark JMini reviews in medicinal chemistry2012 Oct1293-30023092440
Discovery of small molecule fusion inhibitors targeting HIV-1 gp41.Zhou, Guangyan; Chu, ShidongCurrent pharmaceutical design20131818-2623092284
Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Ferguson, Stephen S; Xia, Menghang; Swaan, Peter W; Wang, HongbingPharmaceutical research2013 Feb489-50123090669
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy.Williamson, Elizabeth A; Damiani, Leah; Leitao, Andrei; Hu, Chelin; Hathaway, Helen; Oprea, Tudor; Sklar, Larry; Shaheen, Montaser; Bauman, Julie; Wang, Wei; Nickoloff, Jac A; Lee, Suk-Hee; Hromas, RobertCancer research2012 Dec 16200-823090115
Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids.Kim, Yong Wook; Niphakis, Micah J; Georg, Gunda IThe Journal of organic chemistry2012 Nov 29496-50323088256
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Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes.Seyedsayamdost, Mohammad R; Traxler, Matthew F; Clardy, Jon; Kolter, RobertoMethods in enzymology201289-10923084935
Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design.Custodi, Chiara; Nuti, Roberto; Oprea, Tudor I; Macchiarulo, AntonioJournal of molecular graphics & modelling2012 Sep70-8123079642
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Saldanha, S Adrian; Chase, Peter; Wang, Zhiwei; Civelli, Olivier; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2012 Dec 17135-4123079522
Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells.Le Marchand, Sylvain J; Piston, David WPloS one2012e4708423077547
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Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.Zheng, Weihong; Ibanez, Glorymar; Wu, Hong; Blum, Gil; Zeng, Hong; Dong, Aiping; Li, Fengling; Hajian, Taraneh; Allali-Hassani, Abdellah; Amaya, Maria F; Siarheyeva, Alena; Yu, Wenyu; Brown, Peter J; Schapira, Matthieu; Vedadi, Masoud; Min, Jinrong; Luo, Journal of the American Chemical Society2012 Oct 3118004-1423043551
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ýý-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.Xu, Miao; Liu, Ke; Swaroop, Manju; Porter, Forbes D; Sidhu, Rohini; Firnkes, Sally; Finkes, Sally; Ory, Daniel S; Marugan, Juan J; Xiao, Jingbo; Southall, Noel; Pavan, William J; Davidson, Cristin; Walkley, Steven U; Remaley, Alan T; Baxa, Ulrich; Sun, Wei; McKew, John C; Austin, Christopher P; Zheng, WeiThe Journal of biological chemistry2012 Nov 1639349-6023035117
Identification and characterization of a compound that protects cardiac tissue from human Ether-a-go-go-related gene (hERG)-related drug-induced arrhythmias.Potet, Franck; Lorinc, Amanda N; Chaigne, Sebastien; Hopkins, Corey R; Venkataraman, Raghav; Stepanovic, Svetlana Z; Lewis, L Michelle; Days, Emily; Sidorov, Veniamin Y; Engers, Darren W; Zou, Beiyan; Afshartous, David; George Jr, Alfred L; Campbell, CourThe Journal of biological chemistry2012 Nov 1639613-2523033485
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.Haynes, Stuart W; Gao, Xue; Tang, Yi; Walsh, Christopher TJournal of the American Chemical Society2012 Oct 2417444-723030663
High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A.PLoS One2012e4559423029124
Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.Carr, Gavin; Derbyshire, Emily R; Caldera, Eric; Currie, Cameron R; Clardy, JonJournal of natural products2012 Oct 261806-923025282
MRI biosensor for protein kinase A encoded by a single synthetic gene.Airan, Raag D; Bar-Shir, Amnon; Liu, Guanshu; Pelled, Galit; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf AMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2012 Dec1919-2323023588
Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors.Preuss, Janina; Richardson, Adam D; Pinkerton, Anthony; Hedrick, Michael; Sergienko, Eduard; Rahlfs, Stefan; Becker, Katja; Bode, LarsJournal of biomolecular screening2013 Mar286-9723023104
Exploring chemical diversity via a modular reaction pairing strategy.Loh, Joanna K; Yoon, Sun Young; Samarakoon, Thiwanka B; Rolfe, Alan; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul RBeilstein journal of organic chemistry20121293-30223019462
A coincidence reporter-gene system for high-throughput screening.Cheng KC, Inglese J.Nat Methods2012 Oct93723018994
Briareolate esters from the gorgonian Briareum asbestinum.Meginley, Rian J; Gupta, Prasoon; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon MMarine drugs2012 Aug1662-7023015768
Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics.Kong, Koon Yin; Marcus, Adam I; Giannakakou, Paraskevi; Wang, May DongmeiInternational journal of computational biology and drug design2012298-31323013655
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.Nayar, Ribhu; Enos, Megan; Prince, Amanda; Shin, Hyunmu; Hemmers, Saskia; Jiang, Jian-kang; Klein, Ulf; Thomas, Craig J; Berg, Leslie JProceedings of the National Academy of Sciences of the United States of America2012 Oct 9E2794-80223011795
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.Maloney, Patrick R; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; Li, Linda; Roth, Gregory P; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, FuBioorganic & medicinal chemistry letters2012 Nov 16656-6023010269
Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.Knapp, John M; Zhu, Jie S; Tantillo, Dean J; Kurth, Mark JAngewandte Chemie (International ed. in English)2012 Oct 1510588-9123001913
Rapidly relocating molecules between organelles to manipulate small GTPase activity.Phua, Siew Cheng; Pohlmeyer, Christopher; Inoue, TakanariACS chemical biology2012 Dec 211950-522999378
Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases.Smanski, Michael J; Peterson, Ryan M; Shen, BenMethods in enzymology2012163-8622999174
Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening.Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E.J Transl Med2012 Sep 2119822999104
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.Cacho, Ralph A; Jiang, Wei; Chooi, Yit-Heng; Walsh, Christopher T; Tang, YiJournal of the American Chemical Society2012 Oct 1016781-9022998630
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.Huang, Fen; Zhang, Hongkang; Wu, Meng; Yang, Huanghe; Kudo, Makoto; Peters, Christian J; Woodruff, Prescott G; Solberg, Owen D; Donne, Matthew L; Huang, Xiaozhu; Sheppard, Dean; Fahy, John V; Wolters, Paul J; Hogan, Brigid L M; Finkbeiner, Walter E; Li, MProceedings of the National Academy of Sciences of the United States of America2012 Oct 216354-922988107
Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds.Tomasini-Johansson, Bianca R; Johnson, Ian A; Hoffmann, F Michael; Mosher, Deane FMatrix biology : journal of the International Society for Matrix Biology2012 Jul360-722986508
Structure and biosynthesis of the antibiotic bottromycin D.Hou, Yanpeng; Tianero, Ma Diarey B; Kwan, Jason C; Wyche, Thomas P; Michel, Cole R; Ellis, Gregory A; Vazquez-Rivera, Emmanuel; Braun, Doug R; Rose, Warren E; Schmidt, Eric W; Bugni, Tim SOrganic letters2012 Oct 55050-322984777
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells.Sirenko, Oksana; Crittenden, Carole; Callamaras, Nick; Hesley, Jayne; Chen, Yen-Wen; Funes, Carlos; Rusyn, Ivan; Anson, Blake; Cromwell, Evan FJournal of biomolecular screening2013 Jan39-5322972846
Novel selective allosteric and bitopic ligands for the S1P(3) receptor.Jo, Euijung; Bhhatarai, Barun; Repetto, Emanuela; Guerrero, Miguel; Riley, Sean; Brown, Steven J; Kohno, Yasushi; Roberts, Edward; Schurer, Stephan C; Rosen, HughACS chemical biology2012 Dec 211975-8322971058
Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.Khoury, Kareem; Sinha, Mantosh K; Nagashima, Tadamichi; Herdtweck, Eberhardt; Domling, AlexanderAngewandte Chemie (International ed. in English)2012 Oct 810280-322968839
A dual-column solid phase extraction strategy for online collection and preparation of continuously flowing effluent streams for mass spectrometry.Enders, Jeffrey R; Marasco, Christina C; Wikswo, John P; McLean, John AAnalytical chemistry2012 Oct 168467-7422967262
New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase.Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Kron, Michael; Shen, BenOrganic letters2012 Sep 214946-922967068
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, ANature structural & molecular biology2012 Oct1037-4322961382
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, Albert H C; Blencowe, Benjamin J; Wang, Sun Chong; Kapranov, Philipp; Kustra, Rafal; Labrie, Viviane; Klimasauskas, Saulius; Petronis, ArturasNature structural & molecular biology2012 Oct1037-4322961382
Small molecule inhibitors of RORýýt: targeting Th17 cells and other applications.Huh, Jun R; Littman, Dan REuropean journal of immunology2012 Sep2232-722949321
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.Pouliot, Lynn M; Chen, Yu-Chi; Bai, Jennifer; Guha, Rajarshi; Martin, Scott E; Gottesman, Michael M; Hall, Matthew DCancer research2012 Nov 155945-5522942255
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.Ndjomou, Jean; Kolli, Rajesh; Mukherjee, Sourav; Shadrick, William R; Hanson, Alicia M; Sweeney, Noreena L; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David NAntiviral research2012 Nov245-5522940425
Navigating the fungal polyketide chemical space: from genes to molecules.Chooi, Yit-Heng; Tang, YiThe Journal of organic chemistry2012 Nov 169933-5322938194
Interspecies modulation of bacterial development through iron competition and siderophore piracy.Traxler, Matthew F; Seyedsayamdost, Mohammad R; Clardy, Jon; Kolter, RobertoMolecular microbiology2012 Nov628-4422931126
Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination?Dai, Tianhong; Murray, Clinton K; Vrahas, Mark S; Baer, David G; Tegos, George P; Hamblin, Michael RThe journal of trauma and acute care surgery2012 Sep661-722929495
Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action.Tebbets, Brad; Yu, Zhiguo; Stewart, Douglas; Zhao, Li-Xing; Jiang, Yi; Xu, Li-Hua; Andes, David; Shen, Ben; Klein, BruceMedical mycology : official publication of the International Society for Human and Animal Mycology2012 Aug 2822928922
One-pot phosphine-catalyzed syntheses of quinolines.Khong, San; Kwon, OhyunThe Journal of organic chemistry2012 Sep 218257-6722928667
A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.Mathews, Lesley A; Keller, Jonathan M; Goodwin, Bonnie L; Guha, Rajarshi; Shinn, Paul; Mull, Rebecca; Thomas, Craig J; de Kluyver, Rachel L; Sayers, Thomas J; Ferrer, MarcJournal of biomolecular screening2012 Oct1231-4222927676
High throughput measurement of Caýýýýý dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.Cerignoli, Fabio; Charlot, David; Whittaker, Ross; Ingermanson, Randy; Gehalot, Piyush; Savchenko, Alex; Gallacher, David J; Towart, Rob; Price, Jeffrey H; McDonough, Patrick M; Mercola, MarkJournal of pharmacological and toxicological methods2012 Nov-Dec246-5622926323
Stereoselective synthesis of acortatarins A and B.Wurst, Jacqueline M; Verano, Alyssa L; Tan, Derek SOrganic letters2012 Sep 74442-522924668
Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium.Boudreau, Paul D; Byrum, Tara; Liu, Wei-Ting; Dorrestein, Pieter C; Gerwick, William HJournal of natural products2012 Sep 281560-7022924493
Synthesis of Tetrazolo-Fused Benzodiazepines and Benzodiazepinones by a Two-Step Protocol Using an Ugi-Azide Reaction for Initial Diversity Generation.Gunawan, Steven; Ayaz, Muhammad; De Moliner, Fabio; Frett, Brendan; Kaiser, Christine; Patrick, Nina; Xu, Zhigang; Hulme, ChristopherTetrahedron2012 Jul 85606-561122923851
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry.Strouse, J Jacob; Ivnitski-Steele, Irena; Khawaja, Hadya M; Perez, Dominique; Ricci, Jerec; Yao, Tuanli; Weiner, Warren S; Schroeder, Chad E; Simpson, Denise S; Maki, Brooks E; Li, Kelin; Golden, Jennifer E; Foutz, Terry D; Waller, Anna; Evangelisti, AnneJournal of biomolecular screening2013 Jan26-3822923785
Activation of the ATM-Snail pathway promotes breast cancer metastasis.Sun, Mianen; Guo, Xiaojing; Qian, Xiaolong; Wang, Haibo; Yang, Chunying; Brinkman, Kathryn L; Serrano-Gonzalez, Monica; Jope, Richard S; Zhou, Binhua; Engler, David A; Zhan, Ming; Wong, Stephen T C; Fu, Li; Xu, BoJournal of molecular cell biology2012 Oct304-1522923499
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, KevinNature chemical biology2012 Oct839-4722922757
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin D; Malstrom, Scott; Khan, Tahsin M; Kung, Charles; Skoumbourdis, Amanda P; Veith, Henrike; Southall, Noel; Walsh, Martin J; Brimacombe, Kyle R; Leister, William; Lunt, Sophia Y; Johnson, Zachary R; Yen, Katharine E; Kunii, Kaiko; Davidson, Shawn M; Christofk, Heather R; Austin, Christopher P; Inglese, James; Harris, Marian H; Asara, John M; Stephanopoulos, Gregory; Salituro, Francesco G; Jin, Shengfang; Dang, Lenny; Auld, Douglas S; Park, Hee-Won; Cantley, Lewis C; Thomas, Craig J; Vander Heiden, Matthew GNature chemical biology2012 Oct839-4722922757
Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.Thorne, Natasha; Shen, Min; Lea, Wendy A; Simeonov, Anton; Lovell, Scott; Auld, Douglas S; Inglese, JamesChemistry & biology2012 Aug 241060-7222921073
Total synthesis of (ýý)-hirsutine: application of phosphine-catalyzed imine-allene [4 + 2] annulation.Villa, Reymundo A; Xu, Qihai; Kwon, OhyunOrganic letters2012 Sep 74634-722920858
Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis.O'Reilly, Matthew C; Lindsley, Craig WTetrahedron letters2012 Mar 281539-154222919116
Cyclosporine A and bromocriptine attenuate cell death mediated by intracellular calcium mobilization.Kim, In Ki; Park, So Jung; Park, Jhang Ho; Lee, Seung-Ho; Hong, Sung Eun; Reed, John CBMB reports2012 Aug482-722917034
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFýý interaction.Cunningham, Lea; Finckbeiner, Steven; Hyde, R Katherine; Southall, Noel; Marugan, Juan; Yedavalli, Venkat R K; Dehdashti, Seameen Jean; Reinhold, William C; Alemu, Lemlem; Zhao, Ling; Yeh, Jing-Ruey Joanna; Sood, Raman; Pommier, Yves; Austin, Christopher P; Jeang, Kuan-Teh; Zheng, Wei; Liu, PaulProceedings of the National Academy of Sciences of the United States of America2012 Sep 414592-722912405
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.Mattmann, Margrith E; Yu, Haibo; Lin, Zhihong; Xu, Kaiping; Huang, Xiaofang; Long, Shunyou; Wu, Meng; McManus, Owen B; Engers, Darren W; Le, Uyen M; Li, Min; Lindsley, Craig W; Hopkins, Corey RBioorganic & medicinal chemistry letters2012 Sep 155936-4122910039
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.Morgan, Hugh P; Walsh, Martin J; Blackburn, Elizabeth A; Wear, Martin A; Boxer, Matthew B; Shen, Min; Veith, Henrike; McNae, Iain W; Nowicki, Matthew W; Michels, Paul A M; Auld, Douglas S; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm DThe Biochemical journal2012 Nov 1567-7222906073
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.Gao, Xue; Haynes, Stuart W; Ames, Brian D; Wang, Peng; Vien, Linda P; Walsh, Christopher T; Tang, YiNature chemical biology2012 Oct823-3022902615
Bacterial pathogens commandeer rab GTPases to establish intracellular niches.Stein, Mary-Pat; Muller, Matthias P; Wandinger-Ness, AngelaTraffic (Copenhagen, Denmark)2012 Dec1565-8822901006
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.Seguin, Sandlin P; Ireland, Alex W; Gupta, Tushar; Wright, Christine M; Miyata, Yoshinari; Wipf, Peter; Pipas, James M; Gestwicki, Jason E; Brodsky, Jeffrey LAntiviral research2012 Oct70-8122898086
A suite of modular fluorescence assays interrogate the human immunodeficiency virus glycoprotein-41 coiled coil and assist in determining binding mechanism of low molecular weight fusion inhibitors.Gochin, MiriamAssay and drug development technologies2012 Oct407-1622897493
Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents.Avila, Belem; Roth, Aaron; Streets, Heather; Dwyer, Donard S; Kurth, Mark JBioorganic & medicinal chemistry letters2012 Sep 155976-822892117
Labeling of neuronal receptors and transporters with quantum dots.Chang, Jerry C; Kovtun, Oleg; Blakely, Randy D; Rosenthal, Sandra JWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2012 Nov-Dec605-1922887823
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.Kiffer-Moreira, Tina; Yadav, Manisha C; Zhu, Dongxing; Narisawa, Sonoko; Sheen, Campbell; Stec, Boguslaw; Cosford, Nicholas D; Dahl, Russell; Farquharson, Colin; Hoylaerts, Marc F; Macrae, Vicky E; Millan, Jose LuisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013 Jan81-9122887744
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.Thal, David M; Homan, Kristoff T; Chen, Jun; Wu, Emily K; Hinkle, Patricia M; Huang, Z Maggie; Chuprun, J Kurt; Song, Jianliang; Gao, Erhe; Cheung, Joseph Y; Sklar, Larry A; Koch, Walter J; Tesmer, John J GACS chemical biology2012 Nov 161830-922882301
Exploring uncharted territories: predicting activity cliffs in structure-activity landscapes.Guha, RajarshiJournal of chemical information and modeling2012 Aug 272181-9122873578
Biochemical analysis of protein SUMOylation.Alontaga, Aileen Y; Bobkova, Ekaterina; Chen, YuanCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2012 JulUnit10.2922870855
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.Wu, Victoria M; Chen, Steven C; Arkin, Michelle R; Reiter, Jeremy FProceedings of the National Academy of Sciences of the United States of America2012 Aug 2113644-922864913
Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics.Xu X, Vugmeyster Y.AAPS J2012 Dec781-9122864668
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Gregory, Karen J; Noetzel, Meredith J; Rook, Jerri M; Vinson, Paige N; Stauffer, Shaun R; Rodriguez, Alice L; Emmitte, Kyle A; Zhou, Ya; Chun, Aspen C; Felts, Andrew S; Chauder, Brian A; Lindsley, Craig W; Niswender, Colleen M; Conn, P JeffreyMolecular pharmacology2012 Nov860-7522863693
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.Reith, Alastair D; Bamborough, Paul; Jandu, Karamjit; Andreotti, Daniele; Mensah, Lucy; Dossang, Pamela; Choi, Hwan Geun; Deng, Xianming; Zhang, Jinwei; Alessi, Dario R; Gray, Nathanael SBioorganic & medicinal chemistry letters2012 Sep 15625-922863203
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Qiang; Goldenson, Benjamin; Silver, Serena J; Schenone, Monica; Dancik, Vlado; Huang, Zan; Wang, Ling-Zhi; Lewis, Timothy A; An, W Frank; Li, Xiaoyu; Bray, Mark-Anthony; Thiollier, Clarisse; Diebold, Lauren; Gilles, Laure; Vokes, Martha S; Moore, ChrCell2012 Aug 3575-8922863010
Assembly of four diverse heterocyclic libraries enabled by Prins cyclization, Au-catalyzed enyne cycloisomerization, and automated amide synthesis.Cui, Jiayue; Chai, David I; Miller, Christopher; Hao, Jason; Thomas, Christopher; Wang, JingQi; Scheidt, Karl A; Kozmin, Sergey AThe Journal of organic chemistry2012 Sep 77435-7022860634
Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions.Sahn, James J; Martin, Stephen FACS combinatorial science2012 Aug 2022857149
Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul RACS combinatorial science2012 Aug 13456-922853708
Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method.Zheng, Bo; West, Lyndon MJournal of liquid chromatography & related technologies2009118-13222851883
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.Yang, Chunying; Lee, Michael; Hao, Jianwei; Cui, Xiaoli; Guo, Xiaojing; Smal, Caroline; Bontemps, Francoise; Ma, Shumei; Liu, Xiaodong; Engler, David; Parker, William B; Xu, BoNucleic acids research2012 Oct9621-3222850745
Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target.Treger, R S; Cook, A G; Rai, G; Maloney, D J; Simeonov, A; Jadhav, A; Thomas, C J; Williams, D L; Cappello, M; Vermeire, J JInternational journal for parasitology, drugs and drug resistance2012 Dec 1171-17722844653
Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.Gerea, Alexandra L; Branscum, Katie M; King, Jarrod B; You, Jianlan; Powell, Douglas R; Miller, Andrew N; Spear, John R; Cichewicz, Robert HTetrahedron letters2012 Aug 84202-420522844162
Click-based synthesis of triazolobithiazole ýýF508-CFTR correctors for cystic fibrosis.Donald, Michael B; Rodriguez, Kevin X; Shay, Hannah; Phuan, Puay-Wah; Verkman, A S; Kurth, Mark JBioorganic & medicinal chemistry2012 Sep 15247-5322841006
Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.Bannwarth, Ludovic; Goldberg, Allison B; Chen, Catherine; Turk, Benjamin EChemistry & biology2012 Jul 27875-8222840775
Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ýýýýP and ýýýýC NMR spectroscopy.Jeffries, Rex E; Gamcsik, Michael P; Keshari, Kayvan R; Pediaditakis, Peter; Tikunov, Andrey P; Young, Gregory B; Lee, Haakil; Watkins, Paul B; Macdonald, Jeffrey MTissue engineering. Part C, Methods2013 Feb93-10022835003
Discovery of a novel noniminosugar acid ýý glucosidase chaperone series.Xiao, Jingbo; Westbroek, Wendy; Motabar, Omid; Lea, Wendy A; Hu, Xin; Velayati, Arash; Zheng, Wei; Southall, Noel; Gustafson, Ann Marie; Goldin, Ehud; Sidransky, Ellen; Liu, Ke; Simeonov, Anton; Tamargo, Rafael J; Ribes, Antonia; Matalonga, Leslie; Ferrer, Marc; Marugan, Juan JJournal of medicinal chemistry2012 Sep 137546-5922834902
Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic Dynein-mediated transport of glucocorticoid receptor to the nucleus.Johnston, Paul A; Shinde, Sunita N; Hua, Yun; Shun, Tong Ying; Lazo, John S; Day, Billy WAssay and drug development technologies2012 Oct432-5622830992
Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4.Seyedsayamdost, Mohammad R; Cleto, Sara; Carr, Gavin; Vlamakis, Hera; Joao Vieira, Maria; Kolter, Roberto; Clardy, JonJournal of the American Chemical Society2012 Aug 2213550-322830960
Drug repurposing: far beyond new targets for old drugs.Oprea, T I; Mestres, JThe AAPS journal2012 Dec759-6322826034
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles.Conrad, Wayne E; Rodriguez, Kevin X; Nguyen, Huy H; Fettinger, James C; Haddadin, Makhluf J; Kurth, Mark JOrganic letters2012 Aug 33870-322823414
Development of drugs for Epstein-Barr virus using high-throughput in silico virtual screening.Li, Ning; Thompson, Scott; Jiang, Hualiang; Lieberman, Paul M; Luo, ChengExpert opinion on drug discovery2010 Dec1189-20322822721
Plasma and tissue concentrations of ýý-tocopherol and ýý-tocopherol following high dose dietary supplementation in mice.Baxter, Laura L; Marugan, Juan J; Xiao, Jingbo; Incao, Art; McKew, John C; Zheng, Wei; Pavan, William JNutrients2012 Jun467-9022822447
Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue.Hahn, Kristopher N; Fadeyi, Olugbeminiyi O; Cho, Hyekyung P; Lindsley, Craig WTetrahedron letters2012 Jul 113577-358022822275
Compound collection preparation for virtual screening.Bologa, Cristian G; Oprea, Tudor IMethods in molecular biology (Clifton, N.J.)2012125-4322821595
Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity.Krueger, Aaron B; Dehdashti, Seameen J; Southall, Noel; Marugan, Juan J; Ferrer, Marc; Li, Xueni; Ford, Heide L; Zheng, Wei; Zhao, RuiJournal of biomolecular screening2013 Jan85-9622820394
Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.Choi, Hwan Geun; Zhang, Jianming; Weisberg, Ellen; Griffin, James D; Sim, Taebo; Gray, Nathanael SBioorganic & medicinal chemistry letters2012 Aug 155297-30222819762
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasPreuss, Janina; Maloney, Patrick; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Gosalia, Palak; Milewski, Monika; Li, Yujie Linda; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Vasile, Stefan; Sergienko, Eduard; MangraviJournal of medicinal chemistry2012 Aug 237262-7222813531
Targeting iron assimilation to develop new antibacterials.Foley, Timothy L; Simeonov, AntonExpert opinion on drug discovery2012 Sep831-4722812521
A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6.Polireddy, Kishore; Khan, Mohiuddin Md Taimur; Chavan, Hemantkumar; Young, Susan; Ma, Xiaochao; Waller, Anna; Garcia, Matthew; Perez, Dominique; Chavez, Stephanie; Strouse, Jacob J; Haynes, Mark K; Bologa, Cristian G; Oprea, Tudor I; Tegos, George P; SklaPloS one2012e4000522808084
Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions.Vugmeyster, Yulia; Harrold, John; Xu, XinThe AAPS journal2012 Dec714-2722798020
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, Cheung, Yiu-Yin; Yu, Haibo; Xu, Kaiping; Zou, Beiyan; Wu, Meng; McManus, Owen B; Li, Min; Lindsley, Craig W; Hopkins, Corey RJournal of medicinal chemistry2012 Aug 96975-922793372
Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.Wang, Wei; Cao, Haiping; Wolf, Siglinde; Camacho-Horvitz, Miguel S; Holak, Tad A; Domling, AlexanderBioorganic & medicinal chemistry2013 Jul 153982-9522789708
A multiplexed siRNA screening strategy to identify genes in the PARP pathway.Stec, Erica; Locco, Louis; Szymanski, Stacey; Bartz, Steven R; Toniatti, Carlo; Needham, Rachel H V; Palmieri, Anthony; Carleton, Michael; Cleary, Michele A; Jackson, Aimee L; Linsley, Peter S; Strulovici, Berta; Ferrer, Marc; Santini, FrancescaJournal of biomolecular screening2012 Dec1316-2822786893
Unusual Friedlander Reactions: A Route to Novel Quinoxaline-Based Heterocycles.Shoker, Tharallah A; Ghattass, Khaled I; Fettinger, James C; Kurth, Mark J; Haddadin, Makhluf JOrganic letters2012 Jul 1122783916
O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase.Talukdar, Arindam; Zhao, Yujie; Lv, Wei; Bacher, Adelbert; Illarionov, Boris; Fischer, Markus; Cushman, MarkThe Journal of organic chemistry2012 Jul 206239-6122780198
Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles.Pathak, Tejas P; Osiak, Jaroslaw G; Vaden, Rachel M; Welm, Bryan E; Sigman, Matthew STetrahedron2012 Jul 15203-520822778488
Highly efficient click labeling using 2-[ýýýýýF]fluoroethyl azide and synthesis of an ýýýýýFN-hydroxysuccinimide ester as conjugation agent.Zhou, Dong; Chu, Wenhua; Dence, Carmen S; Mach, Robert H; Welch, Michael JNuclear medicine and biology2012 Nov1175-8122770647
A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel.Yang, Huaiyu; Gao, Zhaobing; Li, Ping; Yu, Kunqian; Yu, Ye; Xu, Tian-Le; Li, Min; Jiang, HualiangBiophysical journal2012 Apr 181815-2522768937
A FRET-based high throughput screening assay to identify inhibitors of anthrax protective antigen binding to capillary morphogenesis gene 2 protein.Rogers, Michael S; Cryan, Lorna M; Habeshian, Kaiane A; Bazinet, Lauren; Caldwell, Thomas P; Ackroyd, P Christine; Christensen, Kenneth APloS one2012e3991122768167
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states.Somvanshi, Vishal S; Sloup, Rudolph E; Crawford, Jason M; Martin, Alexander R; Heidt, Anthony J; Kim, Kwi-suk; Clardy, Jon; Ciche, Todd AScience (New York, N.Y.)2012 Jul 688-9322767929
Discovery of regulators of receptor internalization with high-throughput flow cytometry.Wu, Yang; Tapia, Phillip H; Fisher, Gregory W; Simons, Peter C; Strouse, J Jacob; Foutz, Terry; Waggoner, Alan S; Jarvik, Jonathan; Sklar, Larry AMolecular pharmacology2012 Oct645-5722767611
Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.Grimm, Christian; Jors, Simone; Guo, Zhaohua; Obukhov, Alexander G; Heller, StefanThe Journal of biological chemistry2012 Jun 2922701-822753890
Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes.Choi, Eun Ju; Beatty, Deanna S; Paul, Lauren A; Fenical, William; Jensen, Paul RInternational journal of systematic and evolutionary microbiology2013 Apr1219-2822753528
Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles.Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, ChristopherAngewandte Chemie (International ed. in English)2012 Aug 68037-4022753341
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.Melancon, Bruce J; Utley, Thomas J; Sevel, Christian; Mattmann, Margrith E; Cheung, Yiu-Yin; Bridges, Thomas M; Morrison, Ryan D; Sheffler, Douglas J; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael RBioorganic & medicinal chemistry letters2012 Aug 15035-4022749871
One-Pot, Two-Step Cascade Synthesis of Quinazolinotriazolobenzodiazepines.Guggenheim, Kathryn G; Toru, Hannah; Kurth, Mark JOrganic letters2012 Jun 2922746550
General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.Xu, Zhigang; Ayaz, Muhammad; Cappelli, Alexandra A; Hulme, ChristopherACS combinatorial science2012 Aug 13460-422746181
Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation.Chang, Jerry C; Tomlinson, Ian D; Warnement, Michael R; Ustione, Alessandro; Carneiro, Ana M D; Piston, David W; Blakely, Randy D; Rosenthal, Sandra JThe Journal of neuroscience : the official journal of the Society for Neuroscience2012 Jun 278919-2922745492
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.Zhang, Hongkang; Zou, Beiyan; Yu, Haibo; Moretti, Alessandra; Wang, Xiaoying; Yan, Wei; Babcock, Joseph J; Bellin, Milena; McManus, Owen B; Tomaselli, Gordon; Nan, Fajun; Laugwitz, Karl-Ludwig; Li, MinProceedings of the National Academy of Sciences of the United States of America2012 Jul 1711866-7122745159
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.Mukherjee, Sourav; Hanson, Alicia M; Shadrick, William R; Ndjomou, Jean; Sweeney, Noreena L; Hernandez, John J; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Heck, Julie A; Arnold, Leggy A; Schoenen, Frank J; Frick, David NNucleic acids research2012 Sep 18607-2122740655
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.Salovich, James M; Vinson, Paige N; Sheffler, Douglas J; Lamsal, Atin; Utley, Thomas J; Blobaum, Anna L; Bridges, Thomas M; Le, Uyen; Jones, Carrie K; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, CoBioorganic & medicinal chemistry letters2012 Aug 15084-822738637
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.Frankowski, Kevin J; Hedrick, Michael P; Gosalia, Palak; Li, Kelin; Shi, Shenghua; Whipple, David; Ghosh, Partha; Prisinzano, Thomas E; Schoenen, Frank J; Su, Ying; Vasile, S; Sergienko, Eduard; Gray, Wilson; Hariharan, Santosh; Milan, Loribelle; Heynen-GACS chemical neuroscience2012 Mar 21221-23622737280
TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance.Yuan, Hsiangkuo; Fales, Andrew M; Vo-Dinh, TuanJournal of the American Chemical Society2012 Jul 1811358-6122734608
Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol).Vugmeyster, Yulia; Entrican, Clifford A; Joyce, Alison P; Lawrence-Henderson, Rosemary F; Leary, Beth A; Mahoney, Christopher S; Patel, Himakshi K; Raso, Stephen W; Olland, Stephane H; Hegen, Martin; Xu, XinBioconjugate chemistry2012 Jul 181452-6222731748
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.Delpire, Eric; Baranczak, Aleksandra; Waterson, Alex G; Kim, Kwangho; Kett, Nathan; Morrison, Ryan D; Daniels, J Scott; Weaver, C David; Lindsley, Craig WBioorganic & medicinal chemistry letters2012 Jul 154532-522727639
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRýý and kit.Deng, Xianming; Zhou, Wenjun; Weisberg, Ellen; Wang, Jinhua; Zhang, Jianming; Sasaki, Takaaki; Nelson, Erik; Griffin, James D; Janne, Pasi A; Gray, Nathanael SBioorganic & medicinal chemistry letters2012 Jul 154579-8422727638
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.Smith, Susan M E; Min, Jaeki; Ganesh, Thota; Diebold, Becky; Kawahara, Tsukasa; Zhu, Yerun; McCoy, James; Sun, Aiming; Snyder, James P; Fu, Haian; Du, Yuhong; Lewis, Iestyn; Lambeth, J DavidChemistry & biology2012 Jun 22752-6322726689
Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules.Sun, Hongmao; Shahane, Sampada; Xia, Menghang; Austin, Christopher P; Huang, RuiliJournal of chemical information and modeling2012 Jul 522725677
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.Digby, Gregory J; Noetzel, Meredith J; Bubser, Michael; Utley, Thomas J; Walker, Adam G; Byun, Nellie E; Lebois, Evan P; Xiang, Zixiu; Sheffler, Douglas J; Cho, Hyekyung P; Davis, Albert A; Nemirovsky, Natali E; Mennenga, Sarah E; Camp, Bryan W; Bimonte-NThe Journal of neuroscience : the official journal of the Society for Neuroscience2012 Jun 208532-4422723693
Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol.Fan, Yi Chiao; Kwon, OhyunOrganic letters2012 Jul 63264-722721256
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants.Chen, Yun; Cao, Shugeng; Chai, Yunrong; Clardy, Jon; Kolter, Roberto; Guo, Jian-hua; Losick, RichardMolecular microbiology2012 Aug418-3022716461
Facile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization.Sahn, James J; Martin, Stephen FTetrahedron letters2011 Dec 216855-685822711939
Small molecule perimeter defense in entomopathogenic bacteria.Crawford, Jason M; Portmann, Cyril; Zhang, Xu; Roeffaers, Maarten B J; Clardy, JonProceedings of the National Academy of Sciences of the United States of America2012 Jul 310821-622711807
A high-throughput sphingomyelinase assay using natural substrate.Xu, Miao; Liu, Ke; Southall, Noel; Marugan, Juan J; Remaley, Alan T; Zheng, WeiAnalytical and bioanalytical chemistry2012 Aug407-1422710568
Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones.Gunawan, Steven; Nichol, Gary; Hulme, ChristopherTetrahedron letters2012 Mar 281664-166722707799
A fluorescent screening assay for identifying modulators of GIRK channels.Vazquez, Maribel; Dunn, Charity A; Walsh, Kenneth BJournal of visualized experiments : JoVE201222706581
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.Yang, Yibin; Shaffer 3rd, Arthur L; Emre, N C Tolga; Ceribelli, Michele; Zhang, Meili; Wright, George; Xiao, Wenming; Powell, John; Platig, John; Kohlhammer, Holger; Young, Ryan M; Zhao, Hong; Yang, Yandan; Xu, Weihong; Buggy, Joseph J; Balasubramanian, Sriram; Mathews, Lesley A; Shinn, Paul; Guha, Rajarshi; Ferrer, Marc; Thomas, Craig; Waldmann, Thomas A; Staudt, Louis MCancer cell2012 Jun 12723-3722698399
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.Adibekian, Alexander; Martin, Brent R; Chang, Jae Won; Hsu, Ku-Lung; Tsuboi, Katsunori; Bachovchin, Daniel A; Speers, Anna E; Brown, Steven J; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter S; Rosen, Hugh; Cravatt, Benjamin FJournal of the American Chemical Society2012 Jun 2710345-822690931
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110ýý inhibition as a potential therapeutic strategy.Law, Amanda J; Wang, Yanhong; Sei, Yoshitatsu; O'Donnell, Patricio; Piantadosi, Patrick; Papaleo, Francesco; Straub, Richard E; Huang, Wenwei; Thomas, Craig J; Vakkalanka, Radhakrishna; Besterman, Aaron D; Lipska, Barbara K; Hyde, Thomas M; Harrison, Paul J; Kleinman, Joel E; Weinberger, Daniel RProceedings of the National Academy of Sciences of the United States of America2012 Jul 2412165-7022689948
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.Sekar, Divya; Hahn, Christina; Brune, Bernhard; Roberts, Edward; Weigert, AndreasEuropean journal of immunology2012 Jun1585-9822678911
Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance.Choe, Keith P; Leung, Chi K; Miyamoto, Michael MDrug metabolism reviews2012 Aug209-2322656429
Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.Kaila, Neelu; Huang, Adrian; Moretto, Alessandro; Follows, Bruce; Janz, Kristin; Lowe, Michael; Thomason, Jennifer; Mansour, Tarek S; Hubeau, Cedric; Page, Karen; Morgan, Paul; Fish, Susan; Xu, Xin; Williams, Cara; Saiah, EddineJournal of medicinal chemistry2012 Jun 145088-10922651823
P53 mdm2 inhibitors.Khoury, Kareem; Domling, AlexCurrent pharmaceutical design20124668-7822650254
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.Patnaik, Samarjit; Zheng, Wei; Choi, Jae H; Motabar, Omid; Southall, Noel; Westbroek, Wendy; Lea, Wendy A; Velayati, Arash; Goldin, Ehud; Sidransky, Ellen; Leister, William; Marugan, Juan JJournal of medicinal chemistry2012 Jun 285734-4822646221
siRNA off-target effects in genome-wide screens identify signaling pathway members.Buehler, Eugen; Khan, Aly A; Marine, Shane; Rajaram, Misha; Bahl, Amit; Burchard, Julja; Ferrer, MarcScientific reports201242822645644
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.Gonzalez, David J; Xu, Yuquan; Yang, Yu-Liang; Esquenazi, Eduardo; Liu, Wei-Ting; Edlund, Anna; Duong, Tram; Du, Liangcheng; Molnar, Istvan; Gerwick, William H; Jensen, Paul R; Fischbach, Michael; Liaw, Chih-Chuang; Straight, Paul; Nizet, Victor; DorresteJournal of proteomics2012 Aug 305069-7622641157
Synthesis of peptidomimetics, ýý- and ýý-lactam tetrazoles.Gunawan, Steven; Keck, Kristen; Laetsch, Alex; Hulme, ChristopherMolecular diversity2012 Aug601-622622388
A general, enantioselective synthesis of protected morpholines and piperazines.O'Reilly, Matthew C; Lindsley, Craig WOrganic letters2012 Jun 12910-322616979
Solution-phase synthesis of a highly substituted furan library.Cho, Chul-Hee; Shi, Feng; Jung, Dai-Il; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard CACS combinatorial science2012 Jul 9403-1422612549
The spectral networks paradigm in high throughput mass spectrometry.Guthals, Adrian; Watrous, Jeramie D; Dorrestein, Pieter C; Bandeira, NunoMolecular bioSystems2012 Oct2535-4422610447
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.Chen, Haijun; Tsalkova, Tamara; Mei, Fang C; Hu, Yaohua; Cheng, Xiaodong; Zhou, JiaBioorganic & medicinal chemistry letters2012 Jun 154038-4322607683
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Sheffler, Douglas J; Wenthur, Cody J; Bruner, Joshua A; Carrington, Sheridan J S; Vinson, Paige N; Gogi, Kiran K; Blobaum, Anna L; Morrison, Ryan D; Vamos, Mitchell; Cosford, Nicholas D P; Stauffer, Shaun R; Daniels, J Scott; Niswender, Colleen M; Conn, PBioorganic & medicinal chemistry letters2012 Jun 153921-522607673
Bicyclic C21 terpenoids from the marine sponge Clathria compressa.Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon MJournal of natural products2012 Jun 221223-722607472
Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756).Deng, Xianming; S Gray, NathanaelExpert opinion on therapeutic patents2012 Jun709-1322607035
Non-iminosugar glucocerebrosidase small molecule chaperones.Marugan, Juan Jose; Huang, Wenwei; Motabar, Omid; Zheng, Wei; Xiao, Jingbo; Patnaik, Samarjit; Southall, Noel; Westbroek, Wendy; Lea, Wendy A; Simeonov, Anton; Goldin, Ehud; Debernardi, Maria A; Sidransky, EllenMedChemComm2012 Jan56-6022606365
A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis.Yang, Ruojing; Lacson, Raul G; Castriota, Gino; Zhang, Xiaohua D; Liu, Yaping; Zhao, Wenqing; Einstein, Monica; Camargo, Luiz Miguel; Qureshi, Sajjad; Wong, Kenny K; Zhang, Bei B; Ferrer, Marc; Berger, Joel PPloS one2012e3638422590537
Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.Herman, Ariel G; Hayano, Miki; Poyurovsky, Masha V; Shimada, Kenichi; Skouta, Rachid; Prives, Carol; Stockwell, Brent RCancer discovery2011 Sep312-2522586610
Chiral aminophosphines as catalysts for enantioselective double-Michael indoline syntheses.Khong, San N; Kwon, OhyunMolecules (Basel, Switzerland)20125626-5022580397
Nanofiber-based delivery of bioactive agents and stem cells to bone sites.Zhang, Zhanpeng; Hu, Jiang; Ma, Peter XAdvanced drug delivery reviews2012 Sep1129-4122579758
Parallel synthesis of peptide-like macrocycles containing imidazole-4,5-dicarboxylic acid.Xu, Zhigang; Wheeler, Kraig A; Baures, Paul WMolecules (Basel, Switzerland)20125346-6222569415
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.Ji, Cheng; Lin, Weimin; Moraski, Garrett C; Thanassi, Jane A; Pucci, Michael J; Franzblau, Scott G; Mollmann, Ute; Miller, Marvin JBioorganic & medicinal chemistry2012 Jun 13422-822560837
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges.Vugmeyster, Yulia; Xu, Xin; Theil, Frank-Peter; Khawli, Leslie A; Leach, Michael WWorld journal of biological chemistry2012 Apr 2673-9222558487
Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.Lea, Wendy A; Simeonov, AntonPloS one2012e3621922558390
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Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.Shukla, Sunita J; Huang, Ruili; Simmons, Steven O; Tice, Raymond R; Witt, Kristine L; Vanleer, Danielle; Ramabhadran, Ram; Austin, Christopher P; Xia, MenghangEnvironmental health perspectives2012 Aug1150-622551509
Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen FTetrahedron letters2012 Feb 1477-47922544982
Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles.Shaw, Arthur Y; McLaren, Jonathan A; Nichol, Gary S; Hulme, ChristopherTetrahedron letters2012 May 232592-259422544981
A self-produced trigger for biofilm disassembly that targets exopolysaccharide.Kolodkin-Gal, Ilana; Cao, Shugeng; Chai, Liraz; Bottcher, Thomas; Kolter, Roberto; Clardy, Jon; Losick, RichardCell2012 Apr 27684-9222541437
Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer.LaValle, Courtney R; Zhang, Liyong; Xu, Shuping; Eiseman, Julie L; Wang, Q JaneMolecular cancer therapeutics2012 Jul1389-9922532599
Identification of drug modulators targeting gene-dosage disease CMT1A.Jang, Sung-Wook; Lopez-Anido, Camila; MacArthur, Ryan; Svaren, John; Inglese, JamesACS chemical biology2012 Jul 201205-1322530759
Paradigm shift in toxicity testing and modeling.Sun, Hongmao; Xia, Menghang; Austin, Christopher P; Huang, RuiliThe AAPS journal2012 Sep473-8022528508
Phosphine-catalyzed intramolecular ýý-umpolung addition of ýý-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3-pyrrolines.Andrews, Ian P; Blank, Brian R; Kwon, OhyunChemical communications (Cambridge, England)2012 May 285373-522526463
Nitrosation of aryl and heteroaryltrifluoroborates with nitrosonium tetrafluoroborate.Molander, Gary A; Cavalcanti, Livia NThe Journal of organic chemistry2012 May 44402-1322524190
RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes.Zaretzki, Jed; Rydberg, Patrik; Bergeron, Charles; Bennett, Kristin P; Olsen, Lars; Breneman, Curt MJournal of chemical information and modeling2012 Jun 251637-5922524152
Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.Hellwig, Sabine; Miduturu, Chandra V; Kanda, Shigeru; Zhang, Jianming; Filippakopoulos, Panagis; Salah, Eidarus; Deng, Xianming; Choi, Hwan Geun; Zhou, Wenjun; Hur, Wooyoung; Knapp, Stefan; Gray, Nathanael S; Smithgall, Thomas EChemistry & biology2012 Apr 20529-4022520759
Microbial strain prioritization using metabolomics tools for the discovery of natural products.Hou, Yanpeng; Braun, Doug R; Michel, Cole R; Klassen, Jonathan L; Adnani, Navid; Wyche, Thomas P; Bugni, Tim SAnalytical chemistry2012 May 154277-8322519562
Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform.Dai, Tianhong; Fuchs, Beth B; Coleman, Jeffrey J; Prates, Renato A; Astrakas, Christos; St Denis, Tyler G; Ribeiro, Martha S; Mylonakis, Eleftherios; Hamblin, Michael R; Tegos, George PFrontiers in microbiology201212022514547
Vacuolar H+-ATPase (V-ATPase) promotes vacuolar membrane permeabilization and nonapoptotic death in stressed yeast.Kim, Hyemin; Kim, Adam; Cunningham, Kyle WThe Journal of biological chemistry2012 Jun 119029-3922511765
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.Melancon, Bruce J; Gogliotti, Rocco D; Tarr, James C; Saleh, Sam A; Chauder, Brian A; Lebois, Evan P; Cho, Hyekyung P; Utley, Thomas J; Sheffler, Douglas J; Bridges, Thomas M; Morrison, Ryan D; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; LindBioorganic & medicinal chemistry letters2012 May 153467-7222507963
Scandium(III)-catalyzed enantioselective allylation of isatins using allylsilanes.Hanhan, Nadine V; Tang, Yng C; Tran, Ngon T; Franz, Annaliese KOrganic letters2012 May 42218-2122506841
Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization.Dillon, Myles B C; Bachovchin, Daniel A; Brown, Steven J; Finn, M G; Rosen, Hugh; Cravatt, Benjamin F; Mowen, Kerri AACS chemical biology2012 Jul 201198-20422506763
Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.Musille, Paul M; Pathak, Manish C; Lauer, Janelle L; Hudson, William H; Griffin, Patrick R; Ortlund, Eric ANature structural & molecular biology2012 May532-7, S1-222504882
High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them.Lee, Chrissie Y; Johnson, Ronald L; Wichterman-Kouznetsova, Jennifer; Guha, Rajarshi; Ferrer, Marc; Tuzmen, Pinar; Martin, Scott E; Zhu, Wenge; DePamphilis, Melvin LMethods (San Diego, Calif.)2012 Jun234-4822503772
Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain, Andrew R; Carmody, Leigh C; Morgan, Barbara; Fernandez, Cristina; Forbeck, Erin; Lewis, Timothy A; Nag, Partha P; Ting, Amal; VerPlank, Lynn; Feng, Yuxiong; Perez, Jose R; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric S; Gupta, Piyush B; SBioorganic & medicinal chemistry letters2012 May 153571-422503247
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.Youngsaye, Willmen; Dockendorff, Chris; Vincent, Benjamin; Hartland, Cathy L; Bittker, Joshua A; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L; Munoz, BenitoBioorganic & medicinal chemistry letters2012 May 13362-522497765
Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock.Bucarey, Sergio A; Penn, Kevin; Paul, Lauren; Fenical, William; Jensen, Paul RApplied and environmental microbiology2012 Jun4175-8222492446
Cyanoacetamides (IV): Versatile One-Pot Route to 2-Quinoline-3-carboxamides.Wang, Kan; Herdtweck, Eberhardt; Domling, AlexanderACS combinatorial science2012 Apr 1822486416
A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition.Agola, Jacob O; Hong, Lin; Surviladze, Zurab; Ursu, Oleg; Waller, Anna; Strouse, J Jacob; Simpson, Denise S; Schroeder, Chad E; Oprea, Tudor I; Golden, Jennifer E; Aube, Jeffrey; Buranda, Tione; Sklar, Larry A; Wandinger-Ness, AngelaACS chemical biology2012 Jun 151095-10822486388
Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.Wyche, Thomas P; Hou, Yanpeng; Vazquez-Rivera, Emmanuel; Braun, Doug; Bugni, Tim SJournal of natural products2012 Apr 27735-4022482367
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.Ndungu, J Maina; Krumm, Stefanie A; Yan, Dan; Arrendale, Richard F; Reddy, G Prabhakar; Evers, Taylor; Howard, Randy; Natchus, Michael G; Saindane, Manohar T; Liotta, Dennis C; Plemper, Richard K; Snyder, James P; Sun, AimingJournal of medicinal chemistry2012 May 104220-3022480182
The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity.Ziemert, Nadine; Podell, Sheila; Penn, Kevin; Badger, Jonathan H; Allen, Eric; Jensen, Paul RPloS one2012e3406422479523
ChemModLab: a web-based cheminformatics modeling laboratory.Hughes-Oliver, Jacqueline M; Brooks, Atina D; Welch, William J; Khaledi, Morteza G; Hawkins, Douglas; Young, S Stanley; Patil, Kirtesh; Howell, Gary W; Ng, Raymond T; Chu, Moody TIn silico biology2011-201261-8122475752
A versatile enantioselective synthesis of azabicyclic ring systems: a concise total synthesis of (+)-grandisineýýýD and unnatural analogues.Fadeyi, Olugbeminiyi O; Senter, Timothy J; Hahn, Kristopher N; Lindsley, Craig WChemistry (Weinheim an der Bergstrasse, Germany)2012 May 75826-3122473565
Universal quantification of structurally diverse natural products using an evaporative light scattering detector.Adnani, Navid; Michel, Cole R; Bugni, Tim SJournal of natural products2012 Apr 27802-622471612
Autonomous transmembrane segment S4 of the voltage sensor domain partitions into the lipid membrane.Tiriveedhi, Venkataswarup; Miller, Melissa; Butko, Peter; Li, MinBiochimica et biophysica acta2012 Jul1698-70522465069
Systematic identification of genomic markers of drug sensitivity in cancer cells.Garnett, Mathew J; Edelman, Elena J; Heidorn, Sonja J; Greenman, Chris D; Dastur, Anahita; Lau, King Wai; Greninger, Patricia; Thompson, I Richard; Luo, Xi; Soares, Jorge; Liu, Qingsong; Iorio, Francesco; Surdez, Didier; Chen, Li; Milano, Randy J; BignellNature2012 Mar 29570-522460902
Systematic identification of genomic markers of drug sensitivity in cancer cells.Garnett, Mathew J; Edelman, Elena J; Heidorn, Sonja J; Greenman, Chris D; Dastur, Anahita; Lau, King Wai; Greninger, Patricia; Thompson, I Richard; Luo, Xi; Soares, Jorge; Liu, Qingsong; Iorio, Francesco; Surdez, Didier; Chen, Li; Milano, Randy J; Bignell, Graham R; Tam, Ah T; Davies, Helen; Stevenson, Jesse A; Barthorpe, Syd; Lutz, Stephen R; Kogera, Fiona; Lawrence, Karl; McLaren-Douglas, Anne; Mitropoulos, Xeni; Mironenko, Tatiana; Thi, Helen; Richardson, Laura; Zhou, Wenjun; Jewitt, Frances; Zhang, Tinghu; O'Brien, Patrick; Boisvert, Jessica L; Price, Stacey; Hur, Wooyoung; Yang, Wanjuan; Deng, Xianming; Butler, Adam; Choi, Hwan Geun; Chang, Jae Won; Baselga, Jose; Stamenkovic, Ivan; Engelman, Jeffrey A; Sharma, Sreenath V; Delattre, Olivier; Saez-Rodriguez, Julio; Gray, Nathanael S; Settleman, Jeffrey; Futreal, P Andrew; Haber, Daniel A; Stratton, Michael R; Ramaswamy, Sridhar; McDermott, Ultan; Benes, Cyril HNature2012 Mar 29570-522460902
Bacterial biosynthesis and maturation of the didemnin anti-cancer agents.Xu, Ying; Kersten, Roland D; Nam, Sang-Jip; Lu, Liang; Al-Suwailem, Abdulaziz M; Zheng, Huajun; Fenical, William; Dorrestein, Pieter C; Moore, Bradley S; Qian, Pei-YuanJournal of the American Chemical Society2012 May 238625-3222458477
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Rai, Ganesha; Vyjayanti, Vaddadi N; Dorjsuren, Dorjbal; Simeonov, Anton; Jadhav, Ajit; Wilson 3rd, David M; Maloney, David JJournal of medicinal chemistry2012 Apr 123101-1222455312
Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.MacDonald, Jacob P; Badillo, Joseph J; Arevalo, Gary E; Silva-Garcia, Abel; Franz, Annaliese KACS combinatorial science2012 Apr 9285-9322449252
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis.Smanski, Michael J; Peterson, Ryan M; Huang, Sheng-Xiong; Shen, BenCurrent opinion in chemical biology2012 Apr132-4122445175
Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.Amundsen, Susan K; Spicer, Timothy; Karabulut, Ahmet C; Londono, Luz Marina; Eberhart, Christina; Fernandez Vega, Virneliz; Bannister, Thomas D; Hodder, Peter; Smith, Gerald RACS chemical biology2012 May 18879-9122443934
Enantioselective Pictet-Spengler Reactions of Isatins for the Synthesis of Spiroindolones.Badillo, Joseph J; Silva-Garcia, Abel; Shupe, Benjamin H; Fettinger, James C; Franz, Annaliese KTetrahedron letters2011 Oct 265550-555322442499
Cluster cytometry for high-capacity bioanalysis.Edwards, Bruce S; Zhu, Jingshu; Chen, Jun; Carter, Mark B; Thal, David M; Tesmer, John J G; Graves, Steven W; Sklar, Larry ACytometry. Part A : the journal of the International Society for Analytical Cytology2012 May419-2922438314
Chemistry and biology of multicomponent reactions.Domling, Alexander; Wang, Wei; Wang, KanChemical reviews2012 Jun 133083-13522435608
Screening methods for influenza antiviral drug discovery.Atkins, Colm; Evans, Carrie W; White, E Lucile; Noah, James WExpert opinion on drug discovery2012 May429-3822435452
Application of a homogenous membrane potential assay to assess mitochondrial function.Sakamuru, Srilatha; Li, Xiao; Attene-Ramos, Matias S; Huang, Ruili; Lu, Jianming; Shou, Louie; Shen, Min; Tice, Raymond R; Austin, Christopher P; Xia, MenghangPhysiological genomics2012 May 1495-50322433785
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.Fox, Jennifer T; Sakamuru, Srilatha; Huang, Ruili; Teneva, Nedelina; Simmons, Steven O; Xia, Menghang; Tice, Raymond R; Austin, Christopher P; Myung, KyungjaeProceedings of the National Academy of Sciences of the United States of America2012 Apr 35423-822431602
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists.Koes, David; Khoury, Kareem; Huang, Yijun; Wang, Wei; Bista, Michal; Popowicz, Grzegorz M; Wolf, Siglinde; Holak, Tad A; Domling, Alexander; Camacho, Carlos JPloS one2012e3283922427896
Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive ýý-helix mimetic library.Whitby, Landon R; Boyle, Kristopher E; Cai, Lifeng; Yu, Xiaoqian; Gochin, Miriam; Boger, Dale LBioorganic & medicinal chemistry letters2012 Apr 152861-522424973
Structure-guided design of a high-affinity platelet integrin ýýIIbýý3 receptor antagonist that disrupts Mgýýýýý binding to the MIDAS.Zhu, Jieqing; Choi, Won-Seok; McCoy, Joshua G; Negri, Ana; Zhu, Jianghai; Naini, Sarasija; Li, Jihong; Shen, Min; Huang, Wenwei; Bougie, Daniel; Rasmussen, Mark; Aster, Richard; Thomas, Craig J; Filizola, Marta; Springer, Timothy A; Coller, Barry SScience translational medicine2012 Mar 14125ra3222422993
Combined elemental and biomolecular mass spectrometry imaging for probing the inventory of tissue at a micrometer scale.Matusch, Andreas; Fenn, Larissa S; Depboylu, Candan; Klietz, Martin; Strohmer, Sven; McLean, John A; Becker, J SabineAnalytical chemistry2012 Apr 33170-822413784
High-throughput luciferase reporter assay for small-molecule inhibitors of microRNA function.Connelly, Colleen M; Thomas, Meryl; Deiters, AlexanderJournal of biomolecular screening2012 Jul822-822412086
Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.Li, Kelin; Frankowski, Kevin J; Belon, Craig A; Neuenswander, Ben; Ndjomou, Jean; Hanson, Alicia M; Shanahan, Matthew A; Schoenen, Frank J; Blagg, Brian S J; Aube, Jeffrey; Frick, David NJournal of medicinal chemistry2012 Apr 123319-3022409723
High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.Bialkowska, Agnieszka B; Yang, Vincent WFuture oncology (London, England)2012 Mar259-7222409463
The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.Englund, Erika E; Neumann, Susanne; Eliseeva, Elena; McCoy, Joshua G; Titus, Steven; Zheng, Wei; Southall, Noel; Shin, Paul; Leister, William; Thomas, Craig J; Inglese, James; Austin, Christopher P; Gershengorn, Marvin C; Huang, WenweiMedChemComm2011 Oct1016-102022408719
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.Kopp, Felix; Stratton, Christopher F; Akella, Lakshmi B; Tan, Derek SNature chemical biology2012 Apr358-6522406518
Comparative genomics reveals evidence of marine adaptation in Salinispora species.Penn, Kevin; Jensen, Paul RBMC genomics20128622401625
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.Wang, Xiaoru; You, Jianlan; King, Jarrod B; Powell, Douglas R; Cichewicz, Robert HJournal of natural products2012 Apr 27707-1522400916
In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes.Liu, Guanshu; Moake, Matthew; Har-el, Yah-el; Long, Chris M; Chan, Kannie W Y; Cardona, Amanda; Jamil, Muksit; Walczak, Piotr; Gilad, Assaf A; Sgouros, George; van Zijl, Peter C M; Bulte, Jeff W M; McMahon, Michael TMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2012 Apr1106-1322392814
Direct binding of a hepatitis C virus inhibitor to the viral capsid protein.Kota, Smitha; Takahashi, Virginia; Ni, Feng; Snyder, John K; Strosberg, A DonnyPloS one2012e3220722389688
Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.Faisal, Saqib; Ullah, Farman; Maity, Pradip K; Rolfe, Alan; Samarakoon, Thiwanka B; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Basha, Fatima Z; Organ, Michael G; Hanson, Paul RACS combinatorial science2012 Apr 9268-7222384820
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.Liu G, Abraham S, Tran L, Vickers TD, Xu S, Hadd MJ, Quiambao S, Holladay MW, Hua H, Ford Pulido JM, Gunawardane RN, Davis MI, Eichelberger SR, Apuy JL, Gitnick D, Gardner MF, James J, Breider MA, Belli B, Armstrong RC, Treiber DK.J Med Chem2012 Apr 123250-6022380736
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.Huang, Fei; Mazina, Olga M; Zentner, Isaac J; Cocklin, Simon; Mazin, Alexander VJournal of medicinal chemistry2012 Apr 123011-2022380680
A novel fluorescent general anesthetic enables imaging of sites of action in vivo.Emerson, Daniel J; Liao, Zhengzheng; Eckenhoff, Roderic G; Dmochowski, Ivan JAnesthesiology2012 Jun136322373900
Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry.Gonzalez, David J; Okumura, Cheryl Y; Hollands, Andrew; Kersten, Roland; Akong-Moore, Kathryn; Pence, Morgan A; Malone, Cheryl L; Derieux, Jaclyn; Moore, Bradley S; Horswill, Alexander R; Dixon, Jack E; Dorrestein, Pieter C; Nizet, VictorThe Journal of biological chemistry2012 Apr 2013889-9822371493
In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars.Yuan, Hsiangkuo; Khoury, Christopher G; Wilson, Christy M; Grant, Gerald A; Bennett, Adam J; Vo-Dinh, TuanNanomedicine : nanotechnology, biology, and medicine2012 Nov1355-6322370335
The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.Xiang, Zixiu; Thompson, Analisa D; Brogan, John T; Schulte, Michael L; Melancon, Bruce J; Mi, Debbie; Lewis, L Michelle; Zou, Bende; Yang, Liya; Morrison, Ryan; Santomango, Tammy; Byers, Frank; Brewer, Katrina; Aldrich, Jonathan S; Yu, Haibo; Dawson, EricACS chemical neuroscience2011 Dec 21730-74222368764
Exploiting effectors of Rac GTPase.Jo, Hakryul; Luo, Hongbo RChemistry & biology2012 Feb 24169-7122365599
Identification of mammalian protein quality control factors by high-throughput cellular imaging.Pegoraro, Gianluca; Voss, Ty C; Martin, Scott E; Tuzmen, Pinar; Guha, Rajarshi; Misteli, TomPloS one2012e3168422363705
Cyclopropanations of olefin-containing natural products for simultaneous arming and structure activity studies.Robles, Omar; Serna-Saldivar, Sergio O; Gutierrez-Uribe, Janet A; Romo, DanielOrganic letters2012 Mar 161394-722360738
Straightforward assembly of phenylimidazoquinoxalines via a one-pot two-step MCR process.De Moliner, Fabio; Hulme, ChristopherOrganic letters2012 Mar 21354-722356134
Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines.Coffman, Keith C; Hartley, Timothy P; Dallas, Jerry L; Kurth, Mark JACS combinatorial science2012 Apr 9280-422352295
New advances in MR-compatible bioartificial liver.Jeffries, Rex E; Macdonald, Jeffrey MNMR in biomedicine2012 Mar427-4222351642
Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain.Wyatt, Shelby K; Manning, H Charles; Bai, Mingfeng; Ehtesham, Moneeb; Mapara, Khubaib Y; Thompson, Reid C; Bornhop, Darryl JCurrent molecular medicine2012 May458-6622348613
Transporter-mediated Efflux Influences CNS Side Effects: ABCB1, from Antitarget to Target.Broccatelli, Fabio; Carosati, Emanuele; Cruciani, Gabriele; Oprea, Tudor IMolecular informatics2010 Jan 1216-2622347894
A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission.Conley, Nicholas R; Dragulescu-Andrasi, Anca; Rao, Jianghong; Moerner, W EAngewandte Chemie (International ed. in English)2012 Apr 23350-322344705
Crystal structure of a lipid G protein-coupled receptor.Hanson, Michael A; Roth, Christopher B; Jo, Euijung; Griffith, Mark T; Scott, Fiona L; Reinhart, Greg; Desale, Hans; Clemons, Bryan; Cahalan, Stuart M; Schuerer, Stephan C; Sanna, M Germana; Han, Gye Won; Kuhn, Peter; Rosen, Hugh; Stevens, Raymond CScience (New York, N.Y.)2012 Feb 17851-522344443
A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing.Mousley, Carl J; Yuan, Peihua; Gaur, Naseem A; Trettin, Kyle D; Nile, Aaron H; Deminoff, Stephen J; Dewar, Brian J; Wolpert, Max; Macdonald, Jeffrey M; Herman, Paul K; Hinnebusch, Alan G; Bankaitis, Vytas ACell2012 Feb 17702-1522341443
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.Zhang, Jinwei; Deng, Xianming; Choi, Hwan Geun; Alessi, Dario R; Gray, Nathanael SBioorganic & medicinal chemistry letters2012 Mar 11864-922335897
Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211.Huang, Sheng-Xiong; Wang, Xiang-Jing; Yan, Yijun; Wang, Ji-Dong; Zhang, Ji; Liu, Chong-Xi; Xiang, Wen-Sheng; Shen, BenOrganic letters2012 Mar 21254-722332843
Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.Gunawan, Steven; Petit, Joachim; Hulme, ChristopherACS combinatorial science2012 Mar 12160-322330239
Synthesis of azaphilone-based chemical libraries.Achard, Mathieu; Beeler, Aaron B; Porco Jr, John AACS combinatorial science2012 Mar 12236-4422330196
Synthesis of benzisoxazolines by the coupling of arynes with nitrones.Lu, Chun; Dubrovskiy, Anton V; Larock, Richard CThe Journal of organic chemistry2012 Mar 22279-8422329405
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.Heidebrecht Jr, Richard W; Mulrooney, Carol; Austin, Christopher P; Barker Jr, Robert H; Beaudoin, Jennifer A; Cheng, Ken Chih-Chien; Comer, Eamon; Dandapani, Sivaraman; Dick, Justin; Duvall, Jeremy R; Ekland, Eric H; Fidock, David A; Fitzgerald, Mark E; Foley, Michael; Guha, Rajarshi; Hinkson, Paul; Kramer, Martin; Lukens, Amanda K; Masi, Daniela; Marcaurelle, Lisa A; Su, Xin-Zhuan; Thomas, Craig J; Weiwer, Michel; Wiegand, Roger C; Wirth, Dyann; Xia, Menghang; Yuan, Jing; Zhao, Jinghua; Palmer, Michelle; Munoz, Benito; Schreiber, StuartACS medicinal chemistry letters2012 Feb 9112-11722328964
Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation.Sun, Aiming; Ndungu, J Maina; Krumm, Stefanie A; Yoon, Jeong-Joong; Thepchatri, Pahk; Natchus, Michael; Plemper, Richard K; Snyder, James PACS medicinal chemistry letters2011 Aug 23798-80322328961
Microbubbles in Imaging: Applications Beyond Ultrasound.Kogan, Paul; Gessner, Ryan C; Dayton, Paul ABubble science engineering and technology2010 Jun3-822328906
Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres.Skoda, Erin M; Davis, Gary C; Wipf, PeterOrganic process research & development201226-3422323894
The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.Bernstein, Steven H; Venkatesh, Sundararajan; Li, Min; Lee, Jae; Lu, Bin; Hilchey, Shannon P; Morse, Kimberly M; Metcalfe, Hollie M; Skalska, Jolanta; Andreeff, Michael; Brookes, Paul S; Suzuki, Carolyn KBlood2012 Apr 53321-922323447
Synthesis of ýý-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.Zhang, Jianxiang; Ellsworth, Kristin; Ma, Peter XMacromolecular rapid communications2012 Apr 23664-7122318939
From laptop to benchtop to bedside: structure-based drug design on protein targets.Chen, Lu; Morrow, John K; Tran, Hoang T; Phatak, Sharangdhar S; Du-Cuny, Lei; Zhang, ShuxingCurrent pharmaceutical design20121217-3922316152
Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.Zang, Qin; Javed, Salim; Porubsky, Patrick; Ullah, Farman; Neuenswander, Benjamin; Lushington, Gerald H; Basha, Fatima Z; Organ, Michael G; Hanson, Paul RACS combinatorial science2012 Mar 12211-722311745
High Throughput, Label-free Screening Small Molecule Compound Libraries for Protein-Ligands using Combination of Small Molecule Microarrays and a Special Ellipsometry-based Optical Scanner.Landry, James P; Fei, Yiyan; Zhu, X DInternational drug discovery2011 Dec8-1322306883
Development of small-molecule probes that selectively kill cells induced to express mutant RAS.Weiwer, Michel; Bittker, Joshua A; Lewis, Timothy A; Shimada, Kenichi; Yang, Wan Seok; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Stockwell, Brent R; Schreiber, Stuart L; Munoz, BenitoBioorganic & medicinal chemistry letters2012 Feb 151822-622297109
Identification of SR2211: a potent synthetic RORýý-selective modulator.Kumar, Naresh; Lyda, Brent; Chang, Mi Ra; Lauer, Janelle L; Solt, Laura A; Burris, Thomas P; Kamenecka, Theodore M; Griffin, Patrick RACS chemical biology2012 Apr 20672-722292739
Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.Oprea, Tudor I; Nielsen, Sonny Kim; Ursu, Oleg; Yang, Jeremy J; Taboureau, Olivier; Mathias, Stephen L; Kouskoumvekaki, Lrene; Sklar, Larry A; Bologa, Cristian GMolecular informatics2011 Mar 14100-11122287994
A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists.Tsalkova, Tamara; Mei, Fang C; Cheng, XiaodongPloS one2012e3044122276201
Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening?Tang, Hao; Wang, Xiang Simon; Hsieh, Jui-Hua; Tropsha, AlexanderProteins2012 Jun1503-2122275072
Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.Donald, James R; Wood, Rebekah R; Martin, Stephen FACS combinatorial science2012 Feb 13135-4322273436
High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.Goldin, Ehud; Zheng, Wei; Motabar, Omid; Southall, Noel; Choi, Jae Hyuk; Marugan, Juan; Austin, Christopher P; Sidransky, EllenPloS one2012e2986122272254
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.Lock, Eric F; Abdo, Nour; Huang, Ruili; Xia, Menghang; Kosyk, Oksana; O'Shea, Shannon H; Zhou, Yi-Hui; Sedykh, Alexander; Tropsha, Alexander; Austin, Christopher P; Tice, Raymond R; Wright, Fred A; Rusyn, IvanToxicological sciences : an official journal of the Society of Toxicology2012 Apr578-8822268004
Design, Synthesis, and Biological Evaluation of PKD Inhibitors.George, Kara M; Frantz, Marie-Celine; Bravo-Altamirano, Karla; Lavalle, Courtney R; Tandon, Manuj; Leimgruber, Stephanie; Sharlow, Elizabeth R; Lazo, John S; Wang, Q Jane; Wipf, PeterPharmaceutics2011 Jun186-22822267986
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptorýýý5 (mGluýýý): from an artificial neural network virtual screen to an in vivo tool compound.Mueller, Ralf; Dawson, Eric S; Meiler, Jens; Rodriguez, Alice L; Chauder, Brian A; Bates, Brittney S; Felts, Andrew S; Lamb, Jeffrey P; Menon, Usha N; Jadhav, Sataywan B; Kane, Alexander S; Jones, Carrie K; Gregory, Karen J; Niswender, Colleen M; Conn, P ChemMedChem2012 Mar 5406-1422267125
Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.Wijeratne, E M Kithsiri; Bashyal, Bharat P; Liu, Manping X; Rocha, Danilo D; Gunaherath, G M Kamal B; U'Ren, Jana M; Gunatilaka, Malkanthi K; Arnold, A Elizabeth; Whitesell, Luke; Gunatilaka, A A LeslieJournal of natural products2012 Mar 23361-922264149
Thiosuccinyl peptides as Sirt5-specific inhibitors.He, Bin; Du, Jintang; Lin, HeningJournal of the American Chemical Society2012 Feb 11922-522263694
Improving the prediction of the brain disposition for orally administered drugs using BDDCS.Broccatelli, Fabio; Larregieu, Caroline A; Cruciani, Gabriele; Oprea, Tudor I; Benet, Leslie ZAdvanced drug delivery reviews2012 Jan95-10922261306
Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging.Yuan, Hsiangkuo; Khoury, Christopher G; Hwang, Hanjun; Wilson, Christy M; Grant, Gerald A; Vo-Dinh, TuanNanotechnology2012 Feb 2407510222260928
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.Chen, Jun; Young, Susan M; Allen, Chris; Seeber, Andrew; Peli-Gulli, Marie-Pierre; Panchaud, Nicolas; Waller, Anna; Ursu, Oleg; Yao, Tuanli; Golden, Jennifer E; Strouse, J Jacob; Carter, Mark B; Kang, Huining; Bologa, Cristian G; Foutz, Terry D; Edwards, ACS chemical biology2012 Apr 20715-2222260433
[Diversity of cultured actinomycete in the Baltic Sea].Jiang, Yi; Cao, Yanru; Wang, Qian; Jin, RongxianWei sheng wu xue bao = Acta microbiologica Sinica2011 Nov 41461-722260043
A high throughput scintillation proximity imaging assay for protein methyltransferases.Ibanez, Glorymar; Shum, David; Blum, Gil; Bhinder, Bhavneet; Radu, Constantin; Antczak, Christophe; Luo, Minkui; Djaballah, HakimCombinatorial chemistry & high throughput screening2012 Jun 1359-7122256970
Total Synthesis (+)-7-Bromotrypargine and Unnatural Analogs: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance.Brogan, John T; Stoops, Sydney L; Crews, Brenda C; Marnett, Lawrence J; Lindsley, Craig WACS chemical neuroscience2011 Nov 16633-63922247792
CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism.Wang, Qiang; Hillwig, Matthew L; Wu, Yisheng; Peters, Reuben JPlant physiology2012 Mar1418-2522247270
CEST phase mapping using a length and offset varied saturation (LOVARS) scheme.Song, Xiaolei; Gilad, Assaf A; Joel, Suresh; Liu, Guanshu; Bar-Shir, Amnon; Liang, Yajie; Gorelik, Michael; Pekar, James J; van Zijl, Peter C M; Bulte, Jeff W M; McMahon, Michael TMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2012 Oct1074-8622246684
Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.Weir, Scott J; DeGennaro, Louis J; Austin, Christopher PCancer research2012 Mar 11055-822246671
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.Choi, Jun Yong; Plummer, Mark S; Starr, Jeremy; Desbonnet, Charlene R; Soutter, Holly; Chang, Jeanne; Miller, J Richard; Dillman, Keith; Miller, Alita A; Roush, William RJournal of medicinal chemistry2012 Jan 26852-7022243413
Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes.Vera, Domingo Mariano Adolfo; Haynes, Mark H; Ball, Anthony R; Dai, Tianhong; Astrakas, Christos; Kelso, Michael J; Hamblin, Michael R; Tegos, George PPhotochemistry and photobiology2012 May-Jun499-51122242675
Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines.Xu, Zhigang; Shaw, Arthur Y; Dietrich, Justin; Cappelli, Alexandra P; Nichol, Gary; Hulme, ChristopherMolecular diversity2012 Feb73-922237832
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.Liu, Jinping; Luo, Shukun; Zhao, Hongchang; Liao, Ji; Li, Jing; Yang, Chunying; Xu, Bo; Stern, David F; Xu, Xingzhi; Ye, KeqiongNucleic acids research2012 May3898-91222234877
Enteractinococcus coprophilus gen. nov., sp. nov., of the family Micrococcaceae, isolated from Panthera tigris amoyensis faeces, and transfer of Yaniella fodinae Dhanjal et al. 2011 to the genus Enteractinococcus as Enteractinococcus fodinae comb. nov.Cao, Yan-Ru; Jiang, Yi; Jin, Rong-Xian; Han, Li; He, Wen-Xiang; Li, You-Long; Huang, Xue-Shi; Xue, Quan-HongInternational journal of systematic and evolutionary microbiology2012 Nov2710-622228667
Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration.Vugmeyster, Yulia; Wang, Qin; Xu, Xin; Harrold, John; Daugusta, Daren; Li, Jian; Zollner, Richard; Flannery, Carl R; Rivera-Bermudez, Moises AThe AAPS journal2012 Mar97-10422228117
Synthesis of a ýý-lactam library via formal cycloaddition of imines and substituted succinic anhydrides.Tan, Darlene Q; Atherton, Amy L; Smith, Austin J; Soldi, Cristian; Hurley, Katherine A; Fettinger, James C; Shaw, Jared TACS combinatorial science2012 Mar 12218-2322225535
BDDCS class prediction for new molecular entities.Broccatelli, Fabio; Cruciani, Gabriele; Benet, Leslie Z; Oprea, Tudor IMolecular pharmaceutics2012 Mar 5570-8022224483
Synthetic biological approaches to natural product biosynthesis.Winter, Jaclyn M; Tang, YiCurrent opinion in biotechnology2012 Jan 322221832
Current chemical biology approaches to interrogate protein methyltransferases.Luo, MinkuiACS chemical biology2012 Mar 16443-6322220966
Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.Chen, Catherine Z; Sobczak, Krzysztof; Hoskins, Jason; Southall, Noel; Marugan, Juan J; Zheng, Wei; Thornton, Charles A; Austin, Christopher PAnalytical and bioanalytical chemistry2012 Feb1889-9822218462
Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products.Goodwin, Cody R; Fenn, Larissa S; Derewacz, Dagmara K; Bachmann, Brian O; McLean, John AJournal of natural products2012 Jan 2748-5322216918
Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease.Geng, Haifeng; Whiteley, Grace; Ribbens, Jameson; Zheng, Wei; Southall, Noel; Hu, Xin; Marugan, Juan J; Ferrer, Marc; Maegawa, Gustavo H BPloS one2011e2950422216298
Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.Wang, Qiang; Hillwig, Matthew L; Okada, Kazunori; Yamazaki, Kohei; Wu, Yisheng; Swaminathan, Sivakumar; Yamane, Hisakazu; Peters, Reuben JThe Journal of biological chemistry2012 Feb 246159-6822215681
Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p).Chan, Chun-Yuan; Prudom, Catherine; Raines, Summer M; Charkhzarrin, Sahba; Melman, Sandra D; De Haro, Leyma P; Allen, Chris; Lee, Samuel A; Sklar, Larry A; Parra, Karlett JThe Journal of biological chemistry2012 Mar 2310236-5022215674
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ýýF508 cystic fibrosis transmembrane conductance regulator protein.Knapp, John M; Wood, Alex B; Phuan, Puay-Wah; Lodewyk, Michael W; Tantillo, Dean J; Verkman, A S; Kurth, Mark JJournal of medicinal chemistry2012 Feb 91242-5122214395
The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes.Rath, Christopher M; Dorrestein, Pieter CCurrent opinion in microbiology2012 Apr147-5422209085
Of possible cheminformatics futures.Oprea, Tudor I; Taboureau, Olivier; Bologa, Cristian GJournal of computer-aided molecular design2012 Jan107-1222207193
Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.Dower, Ken; Filone, Claire Marie; Hodges, Erin N; Bjornson, Zach B; Rubins, Kathleen H; Brown, Lauren E; Schaus, Scott; Hensley, Lisa E; Connor, John HJournal of virology2012 Mar2632-4022205744
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.Holmes, Ann R; Keniya, Mikhail V; Ivnitski-Steele, Irena; Monk, Brian C; Lamping, Erwin; Sklar, Larry A; Cannon, Richard DAntimicrobial agents and chemotherapy2012 Mar1508-1522203607
Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography.Streeter, Jason E; Gessner, Ryan C; Tsuruta, James; Feingold, Steven; Dayton, Paul AMolecular imaging2011 Dec460-822201537
Small-molecule proteostasis regulators for protein conformational diseases.Calamini, Barbara; Silva, Maria Catarina; Madoux, Franck; Hutt, Darren M; Khanna, Shilpi; Chalfant, Monica A; Saldanha, S Adrian; Hodder, Peter; Tait, Bradley D; Garza, Dan; Balch, William E; Morimoto, Richard INature chemical biology2012 Feb185-9622198733
Inhibition of the NF-ýýB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.Olivera, Anlys; Moore, Terry W; Hu, Fang; Brown, Andrew P; Sun, Aiming; Liotta, Dennis C; Snyder, James P; Yoon, Younghyoun; Shim, Hyunsuk; Marcus, Adam I; Miller, Andrew H; Pace, Thaddeus W WInternational immunopharmacology2012 Feb368-7722197802
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.Melancon, Bruce J; Lamers, Alexander P; Bridges, Thomas M; Sulikowski, Gary A; Utley, Thomas J; Sheffler, Douglas J; Noetzel, Meredith J; Morrison, Ryan D; Scott Daniels, J; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Wood, Bioorganic & medicinal chemistry letters2012 Jan 151044-822197142
Design of triazole-stapled BCL9 ýý-helical peptides to target the ýý-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction.Kawamoto, Steven A; Coleska, Adriana; Ran, Xu; Yi, Han; Yang, Chao-Yie; Wang, ShaomengJournal of medicinal chemistry2012 Feb 91137-4622196480
Exploring polypharmacology using a ROCS-based target fishing approach.AbdulHameed, Mohamed Diwan M; Chaudhury, Sidhartha; Singh, Narender; Sun, Hongmao; Wallqvist, Anders; Tawa, Gregory JJournal of chemical information and modeling2012 Feb 27492-50522196353
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.Ni, Terri T; Rellinger, Eric J; Mukherjee, Amrita; Xie, Shuying; Stephens, Lauren; Thorne, Curtis A; Kim, Kwangho; Hu, Jiangyong; Lee, Ethan; Marnett, Larry; Hatzopoulos, Antonis K; Zhong, Tao PChemistry & biology2011 Dec 231658-6822195568
Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays.Landry, James P; Fei, Yiyan; Zhu, XiangdongAssay and drug development technologies2012 Jun250-922192305
ýýýýC magnetic resonance spectroscopy detection of changes in serine isotopomers reflects changes in mitochondrial redox status.Johnson, C Bryce; Tikunov, Andrey P; Lee, Haakil; Wolak, Justyna E; Pediaditakis, Peter; Romney, Doug A; Holmuhamedov, Ekhson; Gamcsik, Michael P; Macdonald, Jeffrey MMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2012 Sep671-922190282
Is RORýý a therapeutic target for treating Mycobacterium tuberculosis infections?Baures, Paul WTuberculosis (Edinburgh, Scotland)2012 Jan95-922186085
Expedient synthesis of a 72-membered isoxazolino-*-ketoamide library by a 2ýý3-component reaction.Knapp, John M; Zhu, Jie S; Wood, Alex B; Kurth, Mark JACS combinatorial science2012 Feb 1385-822181856
Omegatides: constrained analogs of peptide primary sequence.Fedoseyenko, Dmytro; Raghuraman, Arjun; Ko, Eunhwa; Burgess, KevinOrganic & biomolecular chemistry2012 Feb 7921-422179815
Microbial metabolic exchange--the chemotype-to-phenotype link.Phelan, Vanessa V; Liu, Wei-Ting; Pogliano, Kit; Dorrestein, Pieter CNature chemical biology2012 Jan26-3522173357
Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway.Theriault, Jimmy R; Felts, Andrew S; Bates, Brittney S; Perez, Jose R; Palmer, Michelle; Gilbert, Shawn R; Dawson, Eric S; Engers, Julie L; Lindsley, Craig W; Emmitte, Kyle ABioorganic & medicinal chemistry letters2012 Jan 176-8122172704
Quantitative high-throughput drug screening identifies novel classes of drugs with anticancer activity in thyroid cancer cells: opportunities for repurposing.Zhang, Lisa; He, Mei; Zhang, Yaqin; Nilubol, Naris; Shen, Min; Kebebew, ElectronThe Journal of clinical endocrinology and metabolism2012 MarE319-2822170715
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization.Ueno, Tasuku; Falkenburger, Bjorn H; Pohlmeyer, Christopher; Inoue, TakanariScience signaling2011ra8722169478
Yeast based small molecule screen for inhibitors of SARS-CoV.Frieman, Matthew; Basu, Dipanwita; Matthews, Krystal; Taylor, Justin; Jones, Grant; Pickles, Raymond; Baric, Ralph; Engel, Daniel APloS one2011e2847922164298
Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors.Daghestani, Hikmat N; Day, Billy WSensors (Basel, Switzerland)20109630-4622163431
Catalytic asymmetric [3+2] annulation of allylsilanes with isatins: synthesis of spirooxindoles.Hanhan, Nadine V; Ball-Jones, Nicolas R; Tran, Ngon T; Franz, Annaliese KAngewandte Chemie (International ed. in English)2012 Jan 23989-9222162028
Phospholipase D as a therapeutic target in brain disorders.Lindsley, Craig W; Brown, H AlexNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012 Jan301-222157867
Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.Costello, Leslie C; Franklin, Renty B; Zou, Jing; Feng, Pei; Bok, Robert; Swanson, Mark G; Kurhanewicz, JohnCancer biology & therapy2011 Dec 151078-8422156800
High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.Zhai, Dayong; Godoi, Paulo; Sergienko, Eduard; Dahl, Russell; Chan, Xochella; Brown, Brock; Rascon, Justin; Hurder, Andrew; Su, Ying; Chung, Thomas D Y; Jin, Chaofang; Diaz, Paul; Reed, John CJournal of biomolecular screening2012 Mar350-6022156224
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.Yeung, Jennifer; Apopa, Patrick L; Vesci, Joanne; Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Holman, Theodore R; Maloney, David J; Boutaud, Olivier; Holinstat, MichaelMolecular pharmacology2012 Mar420-3022155783
MCR synthesis of praziquantel derivatives.Liu, Haixia; William, Samia; Herdtweck, Eberhardt; Botros, Sanaa; Domling, AlexanderChemical biology & drug design2012 Apr470-722151001
Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa).Xu, Meimei; Galhano, Rita; Wiemann, Philipp; Bueno, Emilio; Tiernan, Mollie; Wu, William; Chung, Ill-Min; Gershenzon, Jonathan; Tudzynski, Bettina; Sesma, Ane; Peters, Reuben JThe New phytologist2012 Feb570-522150231
hERGCentral: a large database to store, retrieve, and analyze compound-human Ether-a-go-go related gene channel interactions to facilitate cardiotoxicity assessment in drug development.Du, Fang; Yu, Haibo; Zou, Beiyan; Babcock, Joseph; Long, Shunyou; Li, MinAssay and drug development technologies2011 Dec580-822149888
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.Melancon, Bruce J; Hopkins, Corey R; Wood, Michael R; Emmitte, Kyle A; Niswender, Colleen M; Christopoulos, Arthur; Conn, P Jeffrey; Lindsley, Craig WJournal of medicinal chemistry2012 Feb 231445-6422148748
High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors.Surviladze, Zurab; Young, Susan M; Sklar, Larry AMethods in molecular biology (Clifton, N.J.)2012253-7022144280
Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.Xiang, Zixiu; Thompson, Analisa D; Jones, Carrie K; Lindsley, Craig W; Conn, P JeffreyThe Journal of pharmacology and experimental therapeutics2012 Mar595-60322135383
Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.Yu, Haibo; Wu, Meng; Townsend, Steven D; Zou, Beiyan; Long, Shunyou; Daniels, J Scott; McManus, Owen B; Li, Min; Lindsley, Craig W; Hopkins, Corey RACS chemical neuroscience2011 Oct 19572-57722125664
Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.Odejinmi, Si; Rascon, Rg; Tang, M; Vankayalapati, H; Lai, KACS medicinal chemistry letters2011 Sep 8667-67222125663
Multitasking in the mitochondrion by the ATP-dependent Lon protease.Venkatesh, Sundararajan; Lee, Jae; Singh, Kamalendra; Lee, Irene; Suzuki, Carolyn KBiochimica et biophysica acta2012 Jan56-6622119779
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1Pýýý-R) agonists.Guerrero, Miguel; Urbano, Mariangela; Zhao, Jian; Crisp, Melissa; Chase, Peter; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2012 Jan 1537-4222119461
Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.Cruz, Patricia G; Auld, Douglas S; Schultz, Pamela J; Lovell, Scott; Battaile, Kevin P; MacArthur, Ryan; Shen, Min; Tamayo-Castillo, Giselle; Inglese, James; Sherman, David HChemistry & biology2011 Nov 231442-5222118678
Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.Chen, Junjun; Dexheimer, Thomas S; Ai, Yongxing; Liang, Qin; Villamil, Mark A; Inglese, James; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Zhuang, ZhihaoChemistry & biology2011 Nov 231390-40022118673
Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'.Freel, Kelle C; Edlund, Anna; Jensen, Paul REnvironmental microbiology2012 Feb480-9322117917
Utility-aware screening with clique-oriented prioritization.Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul AJournal of chemical information and modeling2012 Jan 2329-3722117901
Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out.Organ, Michael G; Hanson, Paul R; Rolfe, Alan; Samarakoon, Thiwanka B; Ullah, FarmanJournal of flow chemistry2011 Aug32-3922116791
AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis.Onyenwoke, Rob U; Forsberg, Lawrence J; Liu, Lucy; Williams, Tyisha; Alzate, Oscar; Brenman, Jay EMolecular biology of the cell2012 Jan381-922114351
Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A.Cardellina 2nd, John H; Vieira, Rebecca C; Eccard, Vanessa; Skerry, Janet; Montgomery, Vicki; Campbell, Yvette; Roxas-Duncan, Virginia; Leister, William; Leclair, Christopher A; Maloney, David J; Padula, Daniele; Pescitelli, Gennaro; Khavrutskii, Ilja; Hu, Xin; Wallqvist, Anders; Smith, Leonard AACS medicinal chemistry letters2011 Mar 10396-40122102940
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.Yang, Chunying; Tang, Xi; Guo, Xiaojing; Niikura, Yohei; Kitagawa, Katsumi; Cui, Kemi; Wong, Stephen T C; Fu, Li; Xu, BoMolecular cell2011 Nov 18597-60822099307
High-throughput screening for inhibitors of sialyl- and fucosyltransferases.Rillahan, Cory D; Brown, Steven J; Register, Amy C; Rosen, Hugh; Paulson, James CAngewandte Chemie (International ed. in English)2011 Dec 2312534-722095645
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.Jones, Carrie K; Bubser, Michael; Thompson, Analisa D; Dickerson, Jonathan W; Turle-Lorenzo, Nathalie; Amalric, Marianne; Blobaum, Anna L; Bridges, Thomas M; Morrison, Ryan D; Jadhav, Satyawan; Engers, Darren W; Italiano, Kimberly; Bode, Jacob; Daniels, JThe Journal of pharmacology and experimental therapeutics2012 Feb404-2122088953
Common seed analysis to identify off-target effects in siRNA screens.Marine, Shane; Bahl, Amit; Ferrer, Marc; Buehler, EugenJournal of biomolecular screening2012 Mar370-822086724
PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem.Canny, Stephanie A; Cruz, Yasel; Southern, Mark R; Griffin, Patrick RBioinformatics (Oxford, England)2012 Jan 1140-122084255
Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.Sergienko, Eduard; Xu, Jian; Liu, Wallace H; Dahl, Russell; Critton, David A; Su, Ying; Brown, Brock T; Chan, Xochella; Yang, Li; Bobkova, Ekaterina V; Vasile, Stefan; Yuan, Hongbin; Rascon, Justin; Colayco, Sharon; Sidique, Shyama; Cosford, Nicholas D P;ACS chemical biology2012 Feb 17367-7722070201
Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.Tran, Elizabeth; Sun, Haiyan; Fang, YeAssay and drug development technologies2012 Feb37-4522066912
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.Jhaveri, Komal; Taldone, Tony; Modi, Shanu; Chiosis, GabrielaBiochimica et biophysica acta2012 Mar742-5522062686
Selective molecular sequestration with concurrent natural product functionalization and derivatization: from crude natural product extracts to a single natural product derivative in one step.Krchnak, Viktor; Zajicek, Jaroslav; Miller, Patricia A; Miller, Marvin JThe Journal of organic chemistry2011 Dec 1610249-5322059469
Classification of scaffold-hopping approaches.Sun, Hongmao; Tawa, Gregory; Wallqvist, AndersDrug discovery today2012 Apr310-2422056715
Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format.Moeller, Timothy A; Shukla, Sunita J; Xia, MenghangAssay and drug development technologies2012 Feb78-8722053711
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.Anastasiou, Dimitrios; Poulogiannis, George; Asara, John M; Boxer, Matthew B; Jiang, Jian-kang; Shen, Min; Bellinger, Gary; Sasaki, Atsuo T; Locasale, Jason W; Auld, Douglas S; Thomas, Craig J; Vander Heiden, Matthew G; Cantley, Lewis CScience (New York, N.Y.)2011 Dec 21278-8322052977
A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells.Zwartz, Gordon J; Chigaev, Alexandre; Foutz, Terry D; Edwards, Bruce; Sklar, Larry ACytometry. Part A : the journal of the International Society for Analytical Cytology2011 Mar233-4022045643
Targeting Eph receptors with peptides and small molecules: progress and challenges.Noberini, Roberta; Lamberto, Ilaria; Pasquale, Elena BSeminars in cell & developmental biology2012 Feb51-722044885
Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design.Cai, Lifeng; Gochin, Miriam; Liu, KeliangCurrent topics in medicinal chemistry2011 Dec2959-8422044229
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Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging.Keshari, Kayvan R; Kurhanewicz, John; Bok, Robert; Larson, Peder E Z; Vigneron, Daniel B; Wilson, David MProceedings of the National Academy of Sciences of the United States of America2011 Nov 1518606-1122042839
Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen FACS combinatorial science2012 Jan 975-922040015
Comprehensive analysis of kinase inhibitor selectivity.Davis, Mindy I; Hunt, Jeremy P; Herrgard, Sanna; Ciceri, Pietro; Wodicka, Lisa M; Pallares, Gabriel; Hocker, Michael; Treiber, Daniel K; Zarrinkar, Patrick PNature biotechnology2011 Nov1046-5122037378
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Anastassiadis, Theonie; Deacon, Sean W; Devarajan, Karthik; Ma, Haiching; Peterson, Jeffrey RNature biotechnology2011 Nov1039-4522037377
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.Lewin, Anita H; Miller, Gregory M; Gilmour, BrianBioorganic & medicinal chemistry2011 Dec 17044-822037049
Biology-driven library design for probe discovery.Inglese, James; Hasson, Samuel AChemistry & biology2011 Oct 281204-522035786
Multiplex de novo sequencing of peptide antibiotics.Mohimani, Hosein; Liu, Wei-Ting; Yang, Yu-Liang; Gaudencio, Susana P; Fenical, William; Dorrestein, Pieter C; Pevzner, Pavel AJournal of computational biology : a journal of computational molecular cell biology2011 Nov1371-8122035290
Functional fluorescently labeled bithiazole ýýF508-CFTR corrector imaged in whole body slices in mice.Davison, Holly R; Taylor, Stephanie; Drake, Chris; Phuan, Puay-Wah; Derichs, Nico; Yao, Chenjuan; Jones, Ella F; Sutcliffe, Julie; Verkman, A S; Kurth, Mark JBioconjugate chemistry2011 Dec 212593-922034937
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.Madiraju, Charitha; Welsh, Kate; Cuddy, Michael P; Godoi, Paulo H; Pass, Ian; Ngo, Tram; Vasile, Stefan; Sergienko, Eduard A; Diaz, Paul; Matsuzawa, Shu-Ichi; Reed, John CJournal of biomolecular screening2012 Feb163-7622034497
A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.Motabar, Omid; Goldin, Ehud; Leister, William; Liu, Ke; Southall, Noel; Huang, Wenwei; Marugan, Juan J; Sidransky, Ellen; Zheng, WeiAnalytical and bioanalytical chemistry2012 Jan731-922033823
S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.Gonzalez-Cabrera, Pedro J; Cahalan, Stuart M; Nguyen, Nhan; Sarkisyan, Gor; Leaf, Nora B; Cameron, Michael D; Kago, Tomoyuki; Rosen, HughMolecular pharmacology2012 Feb166-7422031473
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.Utley, Thomas; Haddenham, Dustin; Salovich, James M; Zamorano, Rocio; Vinson, Paige N; Lindsley, Craig W; Hopkins, Corey R; Niswender, Colleen MBioorganic & medicinal chemistry letters2011 Dec 16955-922030026
Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.Chan, Lai N; Fiji, Hannah D G; Watanabe, Masaru; Kwon, Ohyun; Tamanoi, FuyuhikoPloS one2011e2613522028818
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Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury.Zou, Wei; Roth, Robert A; Younis, Husam S; Malle, Ernst; Ganey, Patricia EToxicology2011 Dec 18278-8522019926
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.Roth, Joshua; Minond, Dmitriy; Darout, Etzer; Liu, Qin; Lauer, Janelle; Hodder, Peter; Fields, Gregg B; Roush, William RBioorganic & medicinal chemistry letters2011 Dec 17180-422018790
Identification of small-molecule inhibitors of Trypansoma cruzi replication.Germain, Andrew R; Carmody, Leigh C; Dockendorff, Chris; Galan-Rodriguez, Cristina; Rodriguez, Ana; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Schreiber, Stuart L; Munoz, BenitoBioorganic & medicinal chemistry letters2011 Dec 17197-20022018462
Fluorescent labeling agents change binding profiles of glycan-binding proteins.Fei, Yiyan; Sun, Yung-Shin; Li, Yanhong; Lau, Kam; Yu, Hai; Chokhawala, Harshal A; Huang, Shengshu; Landry, James P; Chen, Xi; Zhu, XiangdongMolecular bioSystems2011 Dec3343-5222009201
An analysis of scale and rotation invariance in the bag-of-features method for histopathological image classification.Raza, S Hussain; Parry, R Mitchell; Moffitt, Richard A; Young, Andrew N; Wang, May DMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention201166-7422003685
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Smardaesidins A-G, isopimarane and 20-nor-isopimarane diterpenoids from Smardaea sp., a fungal endophyte of the moss Ceratodon purpureus.Wang, Xiao-Ning; Bashyal, Bharat P; Wijeratne, E M Kithsiri; U'Ren, Jana M; Liu, Manping X; Gunatilaka, Malkanthi K; Arnold, A Elizabeth; Gunatilaka, A A LeslieJournal of natural products2011 Oct 282052-6121999655
Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus.Liu, Wei-Ting; Kersten, Roland D; Yang, Yu-Liang; Moore, Bradley S; Dorrestein, Pieter CJournal of the American Chemical Society2011 Nov 1618010-321999343
Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on.O'Boyle, Noel M; Guha, Rajarshi; Willighagen, Egon L; Adams, Samuel E; Alvarsson, Jonathan; Bradley, Jean-Claude; Filippov, Igor V; Hanson, Robert M; Hanwell, Marcus D; Hutchison, Geoffrey R; James, Craig A; Jeliazkova, Nina; Lang, Andrew Sid; Langner, Karol M; Lonie, David C; Lowe, Daniel M; Pansanel, Jerome; Pavlov, Dmitry; Spjuth, Ola; Steinbeck, Christoph; Tenderholt, Adam L; Theisen, Kevin J; Murray-Rust, PeterJournal of cheminformatics20113721999342
Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.Sharlow, Elizabeth R; Mustata Wilson, Gabriela; Close, David; Leimgruber, Stephanie; Tandon, Manuj; Reed, Robyn B; Shun, Tong Ying; Wang, Q Jane; Wipf, Peter; Lazo, John SPloS one2011e2513421998636
Palladium(II)-catalyzed dehydrogenative alkenylation of cyclic enaminones via the Fujiwara-Moritani reaction.Yu, Yi-Yun; Niphakis, Micah J; Georg, Gunda IOrganic letters2011 Nov 45932-521995751
Synthesis of caeliferins, elicitors of plant immune responses: accessing lipophilic natural products via cross metathesis.O'Doherty, Inish; Yim, Joshua J; Schmelz, Eric A; Schroeder, Frank COrganic letters2011 Nov 45900-321992613
Enantioselective and regioselective indium(III)-catalyzed addition of pyrroles to isatins.Gutierrez, Elisa G; Wong, Casey J; Sahin, Aziza H; Franz, Annaliese KOrganic letters2011 Nov 45754-721992567
The BioAssay network and its implications to future therapeutic discovery.Zhang, Jintao; Lushington, Gerald H; Huan, JunBMC bioinformatics2011S121988927
Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7.Wu, Yisheng; Hillwig, Matthew L; Wang, Qiang; Peters, Reuben JFEBS letters2011 Nov 43446-5121985968
A mass spectrometry-guided genome mining approach for natural product peptidogenomics.Kersten, Roland D; Yang, Yu-Liang; Xu, Yuquan; Cimermancic, Peter; Nam, Sang-Jip; Fenical, William; Fischbach, Michael A; Moore, Bradley S; Dorrestein, Pieter CNature chemical biology2011 Nov794-80221983601
Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1.Qiao, Kangjian; Chooi, Yit-Heng; Tang, YiMetabolic engineering2011 Nov723-3221983160
Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.Urbano, Mariangela; Guerrero, Miguel; Velaparthi, Subash; Crisp, Melissa; Chase, Peter; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2011 Nov 156739-4521982495
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.Mestres, J; Seifert, S A; Oprea, T IClinical pharmacology and therapeutics2011 Nov662-521975349
Parsimonious discovery of synergistic drug combinations.Severyn, Bryan; Liehr, Robert A; Wolicki, Alex; Nguyen, Kevin H; Hudak, Edward M; Ferrer, Marc; Caldwell, Jeremy S; Hermes, Jeffrey D; Li, Jing; Tudor, MatthewACS chemical biology2011 Dec 161391-821974780
All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease.St Denis, Tyler G; Dai, Tianhong; Izikson, Leonid; Astrakas, Christos; Anderson, Richard Rox; Hamblin, Michael R; Tegos, George PVirulence2011 Nov-Dec509-2021971183
A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots.Chang, Jerry C; Tomlinson, Ian D; Warnement, Michael R; Iwamoto, Hideki; DeFelice, Louis J; Blakely, Randy D; Rosenthal, Sandra JJournal of the American Chemical Society2011 Nov 917528-3121970724
Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes.Fang, Yuesi; Wu, Chunrui; Larock, Richard C; Shi, FengThe Journal of organic chemistry2011 Nov 48840-5121970468
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (Jones, Carrie K; Engers, Darren W; Thompson, Analisa D; Field, Julie R; Blobaum, Anna L; Lindsley, Stacey R; Zhou, Ya; Gogliotti, Rocco D; Jadhav, Satyawan; Zamorano, Rocio; Bogenpohl, Jim; Smith, Yoland; Morrison, Ryan; Daniels, J Scott; Weaver, C David;Journal of medicinal chemistry2011 Nov 107639-4721966889
Methods for Activity Analysis of the Proteins that Regulate Histone Methylation.Quinn AM, Simeonov A.Curr Chem Genomics201195-10521966349
Multiplexed Analysis of Peptide Functionality Using Lanthanide-based Structural Shift Reagents.Kerr, Thomas J; Gant-Branum, Randi L; McLean, John AInternational journal of mass spectrometry2011 Oct 128-3221966243
Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice.Thomsen, Morgane; Lindsley, Craig W; Conn, P Jeffrey; Wessell, Jeffrey E; Fulton, Brian S; Wess, Jurgen; Caine, S BarakPsychopharmacology2012 Apr673-8521964721
Is prolonged stem cell mobilization detrimental for hematopoiesis?Chigaev, Alexandre; Winter, Stuart S; Sklar, Larry AMedical hypotheses2011 Dec1111-321963354
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.Lebois, Evan P; Bridges, Thomas M; Lewis, L Michelle; Dawson, Eric S; Kane, Alexander S; Xiang, Zixiu; Jadhav, Satyawan B; Yin, Huiyong; Kennedy, J Phillip; Meiler, Jens; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Weaver, C David; Lindsley, CACS chemical neuroscience2010104-12121961051
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.Walsh, Martin J; Brimacombe, Kyle R; Veith, Henrike; Bougie, James M; Daniel, Thomas; Leister, William; Cantley, Lewis C; Israelsen, William J; Vander Heiden, Matthew G; Shen, Min; Auld, Douglas S; Thomas, Craig J; Boxer, Matthew BBioorganic & medicinal chemistry letters2011 Nov 16322-721958545
caCORRECT2: Improving the accuracy and reliability of microarray data in the presence of artifacts.Moffitt, Richard A; Yin-Goen, Qiqin; Stokes, Todd H; Parry, R Mitchell; Torrance, James H; Phan, John H; Young, Andrew N; Wang, May DBMC bioinformatics201138321957981
Cell targeting with hybrid Qýý virus-like particles displaying epidermal growth factor.Pokorski, Jonathan K; Hovlid, Marisa L; Finn, M GChembiochem : a European journal of chemical biology2011 Nov 42441-721956837
Workflow and metrics for image quality control in large-scale high-content screens.Bray, Mark-Anthony; Fraser, Adam N; Hasaka, Thomas P; Carpenter, Anne EJournal of biomolecular screening2012 Feb266-7421956170
High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions.Chen, Jun; Carter, Mark B; Edwards, Bruce S; Cai, Hong; Sklar, Larry ACytometry. Part A : the journal of the International Society for Analytical Cytology2012 Jan90-821954189
Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.Huang, Yijun; Wolf, Siglinde; Koes, David; Popowicz, Grzegorz M; Camacho, Carlos J; Holak, Tad A; Domling, AlexanderChemMedChem2012 Jan 249-5221954050
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating la Paz Santangelo, Maria; Gest, Petra M; Guerin, Marcelo E; Coincon, Mathieu; Pham, Ha; Ryan, Gavin; Puckett, Susan E; Spencer, John S; Gonzalez-Juarrero, Mercedes; Daher, Racha; Lenaerts, Anne J; Schnappinger, Dirk; Therisod, Michel; Ehrt, Sabine; SygThe Journal of biological chemistry2011 Nov 1840219-3121949126
High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity.Seguin, Sandlin P; Evans, Carrie W; Nebane-Akah, Miranda; McKellip, Sara; Ananthan, Subramaniam; Tower, Nichole A; Sosa, Melinda; Rasmussen, Lynn; White, E Lucile; Maki, Brooks E; Matharu, Daljit S; Golden, Jennifer E; Aube, Jeffrey; Brodsky, Jeffrey L; NJournal of biomolecular screening2012 Feb194-20321948801
Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.Crawford, Jason M; Mahlstedt, Sarah A; Malcolmson, Steven J; Clardy, Jon; Walsh, Christopher TChemistry & biology2011 Sep 231102-1221944749
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes.Peatey, Christopher L; Spicer, Timothy P; Hodder, Peter S; Trenholme, Katharine R; Gardiner, Donald LMolecular and biochemical parasitology2011 Dec127-3121939693
Direct Hiyama cross-coupling of enaminones with triethoxy(aryl)silanes and dimethylphenylsilanol.Bi, Lei; Georg, Gunda IOrganic letters2011 Oct 215413-521939201
Phospholipase D: enzymology, functionality, and chemical modulation.Selvy, Paige E; Lavieri, Robert R; Lindsley, Craig W; Brown, H AlexChemical reviews2011 Oct 126064-11921936578
Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.Naidu, Mamta D; Agarwal, Rakhi; Pena, Louis A; Cunha, Luis; Mezei, Mihaly; Shen, Min; Wilson 3rd, David M; Liu, Yuan; Sanchez, Zina; Chaudhary, Pankaj; Wilson, Samuel H; Waring, Michael JPloS one2011e2367921935361
Phosphine-initiated general base catalysis: facile access to benzannulated 1,3-diheteroatom five-membered rings via double-Michael reactions of allenes.Szeto, Judy; Sriramurthy, Vardhineedi; Kwon, OhyunOrganic letters2011 Oct 215420-321932819
Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice.Dai, Tianhong; Bil de Arce, Vida J; Tegos, George P; Hamblin, Michael RAntimicrobial agents and chemotherapy2011 Dec5710-721930868
Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet.Benninger, R K P; Head, W Steven; Zhang, Min; Satin, Leslie S; Piston, David WThe Journal of physiology2011 Nov 155453-6621930600
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.Lebois, Evan P; Digby, Gregory J; Sheffler, Douglas J; Melancon, Bruce J; Tarr, James C; Cho, Hyekyung P; Miller, Nicole R; Morrison, Ryan; Bridges, Thomas M; Xiang, Zixiu; Scott Daniels, J; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig WBioorganic & medicinal chemistry letters2011 Nov 16451-521930376
Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41.Zhou, Guangyan; Wu, Dong; Snyder, Beth; Ptak, Roger G; Kaur, Harmeet; Gochin, MiriamJournal of medicinal chemistry2011 Oct 277220-3121928824
Roseobacticides: small molecule modulators of an algal-bacterial symbiosis.Seyedsayamdost, Mohammad R; Carr, Gavin; Kolter, Roberto; Clardy, JonJournal of the American Chemical Society2011 Nov 1618343-921928816
Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.Chou, Danny Hung-Chieh; Duvall, Jeremy R; Gerard, Baudouin; Liu, Haibo; Pandya, Bhaumik A; Suh, Byung-Chul; Forbeck, Erin M; Faloon, Patrick; Wagner, Bridget K; Marcaurelle, Lisa AACS medicinal chemistry letters2011 Sep 8698-70221927648
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.Zang, Qin; Javed, Salim; Ullah, Farman; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Basha, Fatima Z; Organ, Michael G; Hanson, Paul RSynthesis2011 Sep 12743-275021927510
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.Teijaro, John R; Walsh, Kevin B; Cahalan, Stuart; Fremgen, Daniel M; Roberts, Edward; Scott, Fiona; Martinborough, Esther; Peach, Robert; Oldstone, Michael B A; Rosen, HughCell2011 Sep 16980-9121925319
Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.Daghestani, Hikmat N; Zhu, Guangyu; Johnston, Paul A; Shinde, Sunita N; Brodsky, Jeffrey L; Day, Billy WAssay and drug development technologies2012 Feb46-6021919741
Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent.Liu, Guanshu; Liang, Yajie; Bar-Shir, Amnon; Chan, Kannie W Y; Galpoththawela, Chulani S; Bernard, Segun M; Tse, Terence; Yadav, Nirbhay N; Walczak, Piotr; McMahon, Michael T; Bulte, Jeff W M; van Zijl, Peter C M; Gilad, Assaf AJournal of the American Chemical Society2011 Oct 1916326-921919523
Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening.Andriani, Grasiella; Chessler, Anne-Danielle C; Courtemanche, Gilles; Burleigh, Barbara A; Rodriguez, AnaPLoS neglected tropical diseases2011 Auge129821912715
Overview: assays for studying integrin-dependent cell adhesion.Chigaev, Alexandre; Sklar, Larry AMethods in molecular biology (Clifton, N.J.)20123-1421909902
Exploring protein superstructures and dynamics in live bacterial cells using single-molecule and superresolution imaging.Biteen, Julie S; Shapiro, Lucy; Moerner, W EMethods in molecular biology (Clifton, N.J.)2011139-5821909887
Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data.Sun, Hongmao; Veith, Henrike; Xia, Menghang; Austin, Christopher P; Huang, RuiliJournal of chemical information and modeling2011 Oct 242474-8121905670
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.Vidovic, Dusica; Xie, Yuli; Rinderspacher, Alison; Deng, Shi-Xian; Landry, Donald W; Chung, Caty; Smith, Deborah H; Tautz, Lutz; Schurer, Stephan CJournal of computer-aided molecular design2011 Sep873-8321904909
Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines.Suen, Yat Fan; Hope, Hakon; Nantz, Michael H; Haddadin, Makhluf J; Kurth, And Mark JTetrahedron letters2006 Nov 67893-789621904417
Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.Tang, M; Odejinmi, S I; Allette, Y M; Vankayalapati, H; Lai, KBioorganic & medicinal chemistry2011 Oct 15886-9521903402
A brief survey of mRNA surveillance.van Hoof, Ambro; Wagner, Eric JTrends in biochemical sciences2011 Nov585-9221903397
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol.Rolfe, Alan; Ullah, Farman; Samarakoon, Thiwanka B; Kurtz, Ryan D; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul RACS combinatorial science2011 Nov 14653-821902243
Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm.Walsh, Kevin B; Teijaro, John R; Rosen, Hugh; Oldstone, Michael B AImmunologic research2011 Oct15-2521901448
Optimization and application of median filter corrections to relieve diverse spatial patterns in microtiter plate data.Bushway, Paul J; Azimi, Behrad; Heynen-Genel, SusanneJournal of biomolecular screening2011 Oct1068-8021900202
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance.Tsuboi, Katsunori; Bachovchin, Daniel A; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Hodder, Peter; Rosen, Hugh; Cravatt, Benjamin FJournal of the American Chemical Society2011 Oct 1916605-1621899313
A modular reaction pairing approach to the diversity-oriented synthesis of fused- and bridged-polycyclic sultams.Samarakoon, Thiwanka B; Loh, Joanna K; Rolfe, Alan; Le, Lisa S; Yoon, Sun Young; Lushington, Gerald H; Hanson, Paul ROrganic letters2011 Oct 75148-5121899284
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.Ames, Brian D; Haynes, Stuart W; Gao, Xue; Evans, Bradley S; Kelleher, Neil L; Tang, Yi; Walsh, Christopher TBiochemistry2011 Oct 118756-6921899262
Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion.Chamni, Supakarn; He, Qing-Li; Dang, Yongjun; Bhat, Shridhar; Liu, Jun O; Romo, DanielACS chemical biology2011 Nov 181175-8121894934
Antidiabetic actions of a non-agonist PPARýý ligand blocking Cdk5-mediated phosphorylation.Choi, Jang Hyun; Banks, Alexander S; Kamenecka, Theodore M; Busby, Scott A; Chalmers, Michael J; Kumar, Naresh; Kuruvilla, Dana S; Shin, Youseung; He, Yuanjun; Bruning, John B; Marciano, David P; Cameron, Michael D; Laznik, Dina; Jurczak, Michael J; SchurNature2011 Sep 22477-8121892191
Nonomuraea soli sp. nov., an actinomycete isolated from soil.Cao, Yan-Ru; Jin, Rong-Xian; Jiang, Yi; He, Wen-Xiang; Jiang, Cheng-LinInternational journal of systematic and evolutionary microbiology2012 Jul1587-9121890732
Ligand-dependent perturbation of the conformational ensemble for the GPCR ýý2 adrenergic receptor revealed by HDX.West, Graham M; Chien, Ellen Y T; Katritch, Vsevolod; Gatchalian, Jovylyn; Chalmers, Michael J; Stevens, Raymond C; Griffin, Patrick RStructure (London, England : 1993)2011 Oct 121424-3221889352
NRPS substrate promiscuity diversifies the xenematides.Crawford, Jason M; Portmann, Cyril; Kontnik, Renee; Walsh, Christopher T; Clardy, JonOrganic letters2011 Oct 75144-721888371
Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening.Bialkowska, Agnieszka B; Crisp, Melissa; Bannister, Thomas; He, Yuanjun; Chowdhury, Sarwat; Schurer, Stephan; Chase, Peter; Spicer, Timothy; Madoux, Franck; Tian, Chenlu; Hodder, Peter; Zaharevitz, Daniel; Yang, Vincent WMolecular cancer therapeutics2011 Nov2043-5121885866
The role of residue C410 on activation of the human vitamin D receptor by various ligands.Castillo, Hilda S; Ousley, Amanda M; Duraj-Thatte, Anna; Lindstrom, Kelli N; Patel, Dina D; Bommarius, Andreas S; Azizi, BaharehThe Journal of steroid biochemistry and molecular biology2012 Jan76-8621884792
Marine natural products: a new wave of drugs?Montaser, Rana; Luesch, HendrikFuture medicinal chemistry2011 Sep1475-8921882941
Inhibition of marine biofouling by bacterial quorum sensing inhibitors.Dobretsov, Sergey; Teplitski, Max; Bayer, Mirko; Gunasekera, Sarath; Proksch, Peter; Paul, Valerie JBiofouling2011 Sep893-90521882898
Rank order entropy: why one metric is not enough.McLellan, Margaret R; Ryan, M Dominic; Breneman, Curt MJournal of chemical information and modeling2011 Sep 262302-1921875058
Evolution of secondary metabolite genes in three closely related marine actinomycete species.Freel, Kelle C; Nam, Sang-Jip; Fenical, William; Jensen, Paul RApplied and environmental microbiology2011 Oct7261-7021873479
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.Zhao, Li-Xing; Huang, Sheng-Xiong; Tang, Shu-Kun; Jiang, Cheng-Lin; Duan, Yanwen; Beutler, John A; Henrich, Curtis J; McMahon, James B; Schmid, Tobias; Blees, Johanna S; Colburn, Nancy H; Rajski, Scott R; Shen, BenJournal of natural products2011 Sep 231990-521870828
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an ýý-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.Li, Yanran; Chooi, Yit-Heng; Sheng, Yuewei; Valentine, Joan S; Tang, YiJournal of the American Chemical Society2011 Oct 515773-8521866960
Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.Rolfe, Alan; Painter, Thomas O; Asad, Naeem; Hur, Moon Young; Jeon, Kyu Ok; Brzozowski, Marek; Klimberg, Sarra V; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Hanson, Paul RACS combinatorial science2011 Sep 12511-721866904
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors.Wang, Rui; Ibanez, Glorymar; Islam, Kabirul; Zheng, Weihong; Blum, Gil; Sengelaub, Caitlin; Luo, MinkuiMolecular bioSystems2011 Nov2970-8121866297
Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, TuanLangmuir : the ACS journal of surfaces and colloids2011 Oct 412186-9021859159
N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin JJournal of medicinal chemistry2011 Oct 136843-5821859126
Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems.Henrikson, Jon C; Ellis, Trevor K; King, Jarrod B; Cichewicz, Robert HJournal of natural products2011 Sep 231959-6421854017
Cross-pharmacology analysis of G protein-coupled receptors.Brianso, Ferran; Carrascosa, Maria C; Oprea, Tudor I; Mestres, JordiCurrent topics in medicinal chemistry20111956-6321851335
Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam.Montaser, Rana; Paul, Valerie J; Luesch, HendrikPhytochemistry2011 Nov2068-7421843895
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.Martin, S E; Wu, Z-H; Gehlhaus, K; Jones, T L; Zhang, Y-W; Guha, R; Miyamoto, S; Pommier, Y; Caplen, N JCurrent cancer drug targets2011 Oct976-8621834757
Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility.Tran, Hoang T; Zhang, ShuxingJournal of chemical information and modeling2011 Sep 262352-6021834588
Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen FOrganic letters2011 Sep 24542-521834504
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1ýý inhibitors.Huang, Wenwei; Huang, Ruili; Attene-Ramos, Matias S; Sakamuru, Srilatha; Englund, Erika E; Inglese, James; Austin, Christopher P; Xia, MenghangBioorganic & medicinal chemistry letters2011 Sep 155239-4321831635
Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates.Knapp, John M; Fettinger, James C; Kurth, Mark JOrganic letters2011 Sep 24732-521827181
7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.Kiselev, Evgeny; DeGuire, Sean; Morrell, Andrew; Agama, Keli; Dexheimer, Thomas S; Pommier, Yves; Cushman, MarkJournal of medicinal chemistry2011 Sep 86106-1621823606
Human pluripotent stem cells: the development of high-content screening strategies.Sherman, Sean P; Alva, Jackelyn A; Thakore-Shah, Kaushali; Pyle, April DMethods in molecular biology (Clifton, N.J.)2011283-9521822883
Imaging mass spectrometry in microbiology.Watrous, Jeramie D; Dorrestein, Pieter CNature reviews. Microbiology2011 Sep683-9421822293
Discovery, synthesis, and biological evaluation of novel SMN protein modulators.Xiao, Jingbo; Marugan, Juan J; Zheng, Wei; Titus, Steve; Southall, Noel; Cherry, Jonathan J; Evans, Matthew; Androphy, Elliot J; Austin, Christopher PJournal of medicinal chemistry2011 Sep 226215-3321819082
BDDCS applied to over 900 drugs.Benet, Leslie Z; Broccatelli, Fabio; Oprea, Tudor IThe AAPS journal2011 Dec519-4721818695
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.Yuan, Jing; Cheng, Ken Chih-Chien; Johnson, Ronald L; Huang, Ruili; Pattaradilokrat, Sittiporn; Liu, Anna; Guha, Rajarshi; Fidock, David A; Inglese, James; Wellems, Thomas E; Austin, Christopher P; Su, Xin-zhuanScience (New York, N.Y.)2011 Aug 5724-921817045
Metal-free chlorodeboronation of organotrifluoroborates.Molander, Gary A; Cavalcanti, Livia NThe Journal of organic chemistry2011 Sep 27195-20321812468
Phosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways.Na, Risong; Jing, Chengfeng; Xu, Qihai; Jiang, Hui; Wu, Xi; Shi, Jiayan; Zhong, Jiangchun; Wang, Min; Benitez, Diego; Tkatchouk, Ekaterina; Goddard, William A; Guo, Hongchao; Kwon, OhyunJournal of the American Chemical Society2011 Aug 3113337-4821812448
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.Youngsaye, Willmen; Vincent, Benjamin; Hartland, Cathy L; Morgan, Barbara J; Buhrlage, Sara J; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L; MunoBioorganic & medicinal chemistry letters2011 Sep 155502-521802942
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, PatrickChemistry & biology2011 Jul 29868-7921802008
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick; Gray, Nathanael SChemistry & biology2011 Jul 29868-7921802008
Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.Correa, Ricardo G; Khan, Pasha M; Askari, Nadav; Zhai, Dayong; Gerlic, Motti; Brown, Brock; Magnuson, Gavin; Spreafico, Roberto; Albani, Salvatore; Sergienko, Eduard; Diaz, Paul W; Roth, Gregory P; Reed, John CChemistry & biology2011 Jul 29825-3221802003
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Miller, Melissa; Shi, Jie; Zhu, Yingmin; Kustov, Maksym; Tian, Jin-bin; Stevens, Amy; Wu, Meng; Xu, Jia; Long, Shunyou; Yang, Pu; Zholos, Alexander V; Salovich, James M; Weaver, C David; Hopkins, Corey R; Lindsley, Craig W; McManus, Owen; Li, Min; Zhu, MiThe Journal of biological chemistry2011 Sep 2333436-4621795696
SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1Pýýý) receptor.Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2011 Sep 155470-421783362
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.Dennis, Megan K; Field, Angela S; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Bologa, Cristian G; Oprea, Tudor I; Yamaguchi, Yuri; Hayashi, Shin-Ichi; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric RThe Journal of steroid biochemistry and molecular biology2011 Nov358-6621782022
Zeocin for selection of bleMX6 resistance in fission yeast.Benko, Zsigmond; Zhao, Richard YBioTechniques2011 Jul57-6021781055
Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy.Lo, Kai-Yin; Sun, Yung-Shin; Landry, James P; Zhu, Xiangdong; Deng, WenbinBioTechniques2011 Jun381-821781038
Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A.Leighty, Matthew W; Georg, Gunda IACS medicinal chemistry letters2011 Apr 14313-31521779519
A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.Grimes, Kimberly D; Aldrich, Courtney CAnalytical biochemistry2011 Oct 15264-7321771578
A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.Li, Yangmei; Giulianotti, Marc; Houghten, Richard ATetrahedron letters2010 Oct 275637-563921765557
Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds.Choi, Jonghoon; Kim, Kyobum; Kim, Taeho; Liu, Guanshu; Bar-Shir, Amnon; Hyeon, Taeghwan; McMahon, Michael T; Bulte, Jeff W M; Fisher, John P; Gilad, Assaf AJournal of controlled release : official journal of the Controlled Release Society2011 Dec 10239-4521763735
Sequencing cyclic peptides by multistage mass spectrometry.Mohimani, Hosein; Yang, Yu-Liang; Liu, Wei-Ting; Hsieh, Pei-Wen; Dorrestein, Pieter C; Pevzner, Pavel AProteomics2011 Sep3642-5021751357
Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.Brown, Lauren E; Dai, Peng; Porco Jr, John A; Schaus, Scott EOrganic letters2011 Aug 194228-3121749159
Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor.Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; Sherrer, Eric S; McLean, Amanda B; Robins, Allan J; West, Lyndon MOrganic letters2011 Aug 53920-321749084
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches.Ekland, Eric H; Schneider, Jessica; Fidock, David AFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011 Oct3583-9321746861
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, Journal of medicinal chemistry2011 Aug 115485-9721739938
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, David J; Holman, Theodore RJournal of medicinal chemistry2011 Aug 115485-9721739938
Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: synthesis of multisubstituted cyclohexenes.Tran, Yang S; Martin, Tioga J; Kwon, OhyunChemistry, an Asian journal2011 Aug 12101-621739609
First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp.Wyche, Thomas P; Hou, Yanpeng; Braun, Doug; Cohen, Hannah C; Xiong, May P; Bugni, Tim SThe Journal of organic chemistry2011 Aug 196542-721736356
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD.J Biol Chem2011 Sep 931232-4021733839
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening.Prigozhina, Natalie L; Heisel, Andrew; Wei, Ke; Noberini, Roberta; Hunter, Edward A; Calzolari, Diego; Seldeen, Jordan R; Pasquale, Elena B; Ruiz-Lozano, Pilar; Mercola, Mark; Price, Jeffrey HBiology of the cell / under the auspices of the European Cell Biology Organization2011 Oct 1467-8121732911
Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.Asad, Naeem; Hanson, Paul R; Long, Toby R; Rayabarapu, Dinesh K; Rolfe, AlanChemical communications (Cambridge, England)2011 Sep 79528-3021727956
Receptor-based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling.Dong, Xialan; Ebalunode, Jerry O; Yang, Sheng-Yong; Zheng, WeifanCurrent computer-aided drug design2011 Sep 1181-921726192
Animal models of idiosyncratic drug-induced liver injury--current status.Roth, Robert A; Ganey, Patricia ECritical reviews in toxicology2011 Oct723-3921726137
Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola.Edlund, Anna; Loesgen, Sandra; Fenical, William; Jensen, Paul RApplied and environmental microbiology2011 Sep5916-2521724881
Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori.Fei, Y Y; Schmidt, A; Bylund, G; Johansson, D X; Henriksson, S; Lebrilla, C; Solnick, J V; Boren, T; Zhu, X DAnalytical chemistry2011 Aug 156336-4121721569
Synthesis and structure-activity evaluation of isatin-ýý-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.Hall, Matthew D; Brimacombe, Kyle R; Varonka, Matthew S; Pluchino, Kristen M; Monda, Julie K; Li, Jiayang; Walsh, Martin J; Boxer, Matthew B; Warren, Timothy H; Fales, Henry M; Gottesman, Michael MJournal of medicinal chemistry2011 Aug 255878-8921721528
Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling.Cho, Chul-Hee; Jung, Dai-Il; Neuenswander, Benjamin; Larock, Richard CACS combinatorial science2011 Sep 12501-1021721520
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples.Simons, Peter C; Young, Susan M; Carter, Mark B; Waller, Anna; Zhai, Dayong; Reed, John C; Edwards, Bruce S; Sklar, Larry ANature protocols2011 Jul943-5221720309
Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry.Gonzalez, David J; Haste, Nina M; Hollands, Andrew; Fleming, Tinya C; Hamby, Matthew; Pogliano, Kit; Nizet, Victor; Dorrestein, Pieter CMicrobiology (Reading, England)2011 Sep2485-9221719540
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase.Antczak, Christophe; Shum, David; Bassit, Bhramdeo; Frattini, Mark G; Li, Yueming; de Stanchina, Elisa; Scheinberg, David A; Djaballah, HakimBioorganic & medicinal chemistry letters2011 Aug 14528-3221719286
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus.Walsh, Kevin B; Teijaro, John R; Wilker, Peter R; Jatzek, Anna; Fremgen, Daniel M; Das, Subash C; Watanabe, Tokiko; Hatta, Masato; Shinya, Kyoko; Suresh, Marulasiddappa; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B AProceedings of the National Academy of Sciences of the United States of America2011 Jul 1912018-2321715659
QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action.Artemenko, A G; Muratov, E N; Kuz'min, V E; Muratov, N N; Varlamova, E V; Kuz'mina, A V; Gorb, L G; Golius, A; Hill, F C; Leszczynski, J; Tropsha, ASAR and QSAR in environmental research2011 Jul-Sep575-60121714735
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.Peterson, Katherine E; Cinelli, Maris A; Morrell, Andrew E; Mehta, Akhil; Dexheimer, Thomas S; Agama, Keli; Antony, Smitha; Pommier, Yves; Cushman, MarkJournal of medicinal chemistry2011 Jul 284937-5321710981
A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae.Rasmussen, Lynn; White, E Lucile; Pathak, Ashish; Ayala, Julio C; Wang, Hongxia; Wu, Jian-He; Benitez, Jorge A; Silva, Anisia JAntimicrobial agents and chemotherapy2011 Sep4134-4321709090
Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry.Kliman, Michal; May, Jody C; McLean, John ABiochimica et biophysica acta2011 Nov935-4521708282
Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp.Meickle, Theresa; Gunasekera, Sarath P; Liu, Yanxia; Luesch, Hendrik; Paul, Valerie JBioorganic & medicinal chemistry2011 Nov 156576-8021705224
In situ kinase profiling reveals functionally relevant properties of native kinases.Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Wu, Jiangyue; Brown, Heidi; Zhou, David; Zhang, Jianming; Jagannathan, Subadhra; Aban, Arwin; Okerberg, Eric; Herring, Chris; Nordin, Brian; Weissig, Helge; Yang, Qingkai; Lee, Jiing-Dwan; Gray, Nathanael S; KozChemistry & biology2011 Jun 24699-71021700206
Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4.Seyedsayamdost, Mohammad R; Traxler, Matthew F; Zheng, Shao-Liang; Kolter, Roberto; Clardy, JonJournal of the American Chemical Society2011 Aug 311434-721699219
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors.Lone, Anna Mari; Bachovchin, Daniel A; Westwood, David B; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Rosen, Hugh; Cravatt, Benjamin F; Saghatelian, AlanJournal of the American Chemical Society2011 Aug 311665-7421692504
Enhancing the rate of scaffold discovery with diversity-oriented prioritization.Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul ABioinformatics (Oxford, England)2011 Aug 152271-821685049
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.Gonzalez-Lopez, Marcos; Welsh, Kate; Finlay, Darren; Ardecky, Robert J; Ganji, Santhi Reddy; Su, Ying; Yuan, Hongbin; Teriete, Peter; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D PBioorganic & medicinal chemistry letters2011 Jul 154332-621680182
Up-regulation of A-type potassium currents protects neurons against cerebral ischemia.Deng, Ping; Pang, Zhi-Ping; Lei, Zhigang; Shikano, Sojin; Xiong, Qiaojie; Harvey, Brandon K; London, Barry; Wang, Yun; Li, Min; Xu, Zao CJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011 Sep1823-3521673715
Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.Espinoza, Stefano; Salahpour, Ali; Masri, Bernard; Sotnikova, Tatyana D; Messa, Mirko; Barak, Larry S; Caron, Marc G; Gainetdinov, Raul RMolecular pharmacology2011 Sep416-2521670104
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.Dever, Seth M; Golding, Sarah E; Rosenberg, Elizabeth; Adams, Bret R; Idowu, Michael O; Quillin, John M; Valerie, Nicholas; Xu, Bo; Povirk, Lawrence F; Valerie, KristofferAging2011 May515-3221666281
Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones.Kantevari, Srinivas; Yempala, Thirumal; Yogeeswari, Perumal; Sriram, Dharmarajan; Sridhar, BalasubramanianBioorganic & medicinal chemistry letters2011 Jul 154316-921665469
Reconstituting the key steps of the DNA double-strand break repair in vitro.Rossi, Matthew J; Bugreev, Dmitry V; Mazina, Olga M; Mazin, Alexander VMethods in molecular biology (Clifton, N.J.)2011407-2021660707
Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.Agola, J O; Jim, P A; Ward, H H; Basuray, S; Wandinger-Ness, AClinical genetics2011 Oct305-1821651512
Synthesis of spiro-fused pyrazolidoylisoxazolines.Guggenheim, Kathryn G; Butler, Jeffrey D; Painter, Phillip P; Lorsbach, Beth A; Tantillo, Dean J; Kurth, Mark JThe Journal of organic chemistry2011 Jul 155803-1221650164
Design, synthesis, and diversification of 3,5-substituted enone library.Khalaf, Juhienah; Estrella-Jimenez, Maria E; Shashack, Matthew J; Phatak, Sharangdhar S; Zhang, Shuxing; Gilbertson, Scott RACS combinatorial science2011 Jul 11351-621648460
2D NMR-spectroscopic screening reveals polyketides in ladybugs.Deyrup, Stephen T; Eckman, Laura E; McCarthy, Patrick H; Smedley, Scott R; Meinwald, Jerrold; Schroeder, Frank CProceedings of the National Academy of Sciences of the United States of America2011 Jun 149753-821646540
Two High Throughput Screen Assays for Measurement of TNF-ýý in THP-1 Cells.Leister, Kristin P; Huang, Ruili; Goodwin, Bonnie L; Chen, Andrew; Austin, Christopher P; Xia, MenghangCurrent chemical genomics201121-921643507
Exploratory analysis of kinetic solubility measurements of a small molecule library.Guha, Rajarshi; Dexheimer, Thomas S; Kestranek, Aimee N; Jadhav, Ajit; Chervenak, Andrew M; Ford, Michael G; Simeonov, Anton; Roth, Gregory P; Thomas, Craig JBioorganic & medicinal chemistry2011 Jul 14127-3421640593
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.Bachovchin, Daniel A; Zuhl, Andrea M; Speers, Anna E; Wolfe, Monique R; Weerapana, Eranthie; Brown, Steven J; Rosen, Hugh; Cravatt, Benjamin FJournal of medicinal chemistry2011 Jul 285229-3621639134
RGD-conjugated human ferritin nanoparticles for imaging vascular inflammation and angiogenesis in experimental carotid and aortic disease.Kitagawa, Toshiro; Kosuge, Hisanori; Uchida, Masaki; Dua, Monica M; Iida, Yasunori; Dalman, Ronald L; Douglas, Trevor; McConnell, Michael VMolecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging2012 Jun315-2421638084
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.Sooryakumar, Dhriti; Dexheimer, Thomas S; Teicher, Beverly A; Pommier, YvesMolecular cancer therapeutics2011 Aug1490-921636699
The JAK2/STAT3 signaling pathway is required for growth of CD44ýýýCD24ýýý stem cell-like breast cancer cells in human tumors.Marotta, Lauren L C; Almendro, Vanessa; Marusyk, Andriy; Shipitsin, Michail; Schemme, Janina; Walker, Sarah R; Bloushtain-Qimron, Noga; Kim, Jessica J; Choudhury, Sibgat A; Maruyama, Reo; Wu, Zhenhua; Gonen, Mithat; Mulvey, Laura A; Bessarabova, Marina O;The Journal of clinical investigation2011 Jul2723-3521633165
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.Shukla, Suneet; Skoumbourdis, Amanda P; Walsh, Martin J; Hartz, Anika M S; Fung, King Leung; Wu, Chung-Pu; Gottesman, Michael M; Bauer, Bjorn; Thomas, Craig J; Ambudkar, Suresh VMolecular pharmaceutics2011 Aug 11292-30221630681
Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish.Wythe, Joshua D; Jurynec, Michael J; Urness, Lisa D; Jones, Christopher A; Sabeh, M Khaled; Werdich, Andreas A; Sato, Mariko; Yost, H Joseph; Grunwald, David J; Macrae, Calum A; Li, Dean YDisease models & mechanisms2011 Sep-Oct607-2121628396
Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization.Pokorski, Jonathan K; Breitenkamp, Kurt; Liepold, Lars O; Qazi, Shefah; Finn, M GJournal of the American Chemical Society2011 Jun 229242-521627118
Fluorescent proton sensors based on energy transfer.Thivierge, Cliferson; Han, Junyan; Jenkins, Roxanne M; Burgess, KevinThe Journal of organic chemistry2011 Jul 15219-2821618970
Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.Reyes, Maribel; Benet, Leslie ZJournal of pharmaceutical sciences2011 Sep3831-4221618544
Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.Wang, Hao-Ran; Wu, Meng; Yu, Haibo; Long, Shunyou; Stevens, Amy; Engers, Darren W; Sackin, Henry; Daniels, J Scott; Dawson, Eric S; Hopkins, Corey R; Lindsley, Craig W; Li, Min; McManus, Owen BACS chemical biology2011 Aug 19845-5621615117
Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.Carr, Gavin; Seyedsayamdost, Mohammad R; Chandler, Josephine R; Greenberg, E Peter; Clardy, JonOrganic letters2011 Jun 173048-5121615115
Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.Forseth, Ry R; Fox, Ellen M; Chung, DaWoon; Howlett, Barbara J; Keller, Nancy P; Schroeder, Frank CJournal of the American Chemical Society2011 Jun 299678-8121612254
The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles.Conrad, Wayne E; Fukazawa, Ryo; Haddadin, Makhluf J; Kurth, Mark JOrganic letters2011 Jun 173138-4121612219
Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument.Baillargeon, Pierre; Scampavia, Louis; Einsteder, Ross; Hodder, PeterJournal of laboratory automation2011 Jun197-20321609702
Development of p97 AAA ATPase inhibitors.Chou, Tsui-Fen; Deshaies, Raymond JAutophagy2011 Sep1091-221606684
Structural determinants of the alpha2 adrenoceptor subtype selectivity.Ostopovici-Halip, Liliana; Curpan, Ramona; Mracec, Maria; Bologa, Cristian GJournal of molecular graphics & modelling2011 Aug1030-821602069
Multicomponent assembly and diversification of novel heterocyclic scaffolds derived from 2-arylpiperidines.Hardy, Simon; Martin, Stephen FOrganic letters2011 Jun 173102-521598984
Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.Xia, Menghang; Guo, Vicky; Huang, Ruili; Shahane, Sampada A; Austin, Christopher P; Nirenberg, Marshall; Sharma, Shail KCellular and molecular neurobiology2011 Aug901-721598037
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.Xu, Cheng-Ran; Cole, Philip A; Meyers, David J; Kormish, Jay; Dent, Sharon; Zaret, Kenneth SScience (New York, N.Y.)2011 May 20963-621596989
Bacterial symbionts and natural products.Crawford, Jason M; Clardy, JonChemical communications (Cambridge, England)2011 Jul 217559-6621594283
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.Haynes, Stuart W; Ames, Brian D; Gao, Xue; Tang, Yi; Walsh, Christopher TBiochemistry2011 Jun 285668-7921591693
Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry.Yang, Yu-Liang; Xu, Yuquan; Kersten, Roland D; Liu, Wei-Ting; Meehan, Michael J; Moore, Bradley S; Bandeira, Nuno; Dorrestein, Pieter CAngewandte Chemie (International ed. in English)2011 Jun 205839-4221574228
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Guerrero, Miguel; Urbano, Mariangela; Velaparthi, Subash; Zhao, Jian; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, EdwardBioorganic & medicinal chemistry letters2011 Jun 153632-621570287
Synthesis, activity, and structural analysis of novel ýý-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Chung, Suhman; Himmel, Daniel M; Jiang, Jian-Kang; Wojtak, Krzysztof; Bauman, Joseph D; Rausch, Jason W; Wilson, Jennifer A; Beutler, John A; Thomas, Craig J; Arnold, Eddy; Le Grice, Stuart F JJournal of medicinal chemistry2011 Jul 144462-7321568335
Characterizing the diversity and biological relevance of the MLPCN assay manifold and screening set.Zhang, Jintao; Lushington, Gerald H; Huan, JunJournal of chemical information and modeling2011 Jun 271205-1521568288
High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.Curpan, Ramona F; Simons, Peter C; Zhai, Dayong; Young, Susan M; Carter, Mark B; Bologa, Cristian G; Oprea, Tudor I; Satterthwait, Arnold C; Reed, John C; Edwards, Bruce S; Sklar, Larry AAssay and drug development technologies2011 Oct465-7421561376
Solving the puzzle of metastasis: the evolution of cell migration in neoplasms.Chen, Jun; Sprouffske, Kathleen; Huang, Qihong; Maley, Carlo CPloS one2011e1793321556134
Magnetic resonance imaging of cells in experimental disease models.Muja, Naser; Bulte, Jeff W MProgress in nuclear magnetic resonance spectroscopy2009 Jul61-7721552511
Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and ýý-amino alcohols.Fan, Yi Chiao; Kwon, OhyunMolecules (Basel, Switzerland)20113802-2521546881
Proteostasis: a new therapeutic paradigm for pulmonary disease.Bouchecareilh, Marion; Balch, William EProceedings of the American Thoracic Society2011 May189-9521543800
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.Huang, Ruili; Xia, Menghang; Cho, Ming-Hsuang; Sakamuru, Srilatha; Shinn, Paul; Houck, Keith A; Dix, David J; Judson, Richard S; Witt, Kristine L; Kavlock, Robert J; Tice, Raymond R; Austin, Christopher PEnvironmental health perspectives2011 Aug1142-821543282
Agonist-directed desensitization of the ýý2-adrenergic receptor.Goral, Vasiliy; Jin, Yan; Sun, Haiyan; Ferrie, Ann M; Wu, Qi; Fang, YePloS one2011e1928221541288
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.Wurst, Jacqueline M; Liu, Guodong; Tan, Derek SJournal of the American Chemical Society2011 May 257916-2521539313
Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.Dahl, Russell; Bravo, Yalda; Sharma, Vandana; Ichikawa, Mie; Dhanya, Raveendra-Panickar; Hedrick, Michael; Brown, Brock; Rascon, Justin; Vicchiarelli, Michael; Mangravita-Novo, Arianna; Yang, Li; Stonich, Derek; Su, Ying; Smith, Layton H; Sergienko, EduarJournal of medicinal chemistry2011 May 263661-821539312
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.Yamamoto, Kimiyo N; Hirota, Kouji; Kono, Koichi; Takeda, Shunichi; Sakamuru, Srilatha; Xia, Menghang; Huang, Ruili; Austin, Christopher P; Witt, Kristine L; Tice, Raymond REnvironmental and molecular mutagenesis2011 Aug547-6121538559
High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis.Li, Angela Ying-Jian; Lin, Her Helen; Kuo, Ching-Ying; Shih, Hsiu-Ming; Wang, Clay Chia Chun; Yen, Yun; Ann, David KongMolecular and cellular biology2011 Jul2605-1721536653
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.Kotsikorou, Evangelia; Madrigal, Karla E; Hurst, Dow P; Sharir, Haleli; Lynch, Diane L; Heynen-Genel, Susanne; Milan, Loribelle B; Chung, Thomas D Y; Seltzman, Herbert H; Bai, Yushi; Caron, Marc G; Barak, Larry; Abood, Mary E; Reggio, Patricia HBiochemistry2011 Jun 285633-4721534610
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage.Grindberg, Rashel V; Ishoey, Thomas; Brinza, Dumitru; Esquenazi, Eduardo; Coates, R Cameron; Liu, Wei-ting; Gerwick, Lena; Dorrestein, Pieter C; Pevzner, Pavel; Lasken, Roger; Gerwick, William HPloS one2011e1856521533272
RS-predictor: a new tool for predicting sites of cytochrome P450-mediated metabolism applied to CYP 3A4.Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik; Huang, Tao-wei; Bennett, Kristin P; Breneman, Curt MJournal of chemical information and modeling2011 Jul 251667-8921528931
Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data.Chalmers, Michael J; Pascal, Bruce D; Willis, Scooter; Zhang, Jun; Iturria, Stephen J; Dodge, Jeffery A; Griffin, Patrick RInternational journal of mass spectrometry2011 Apr 3059-6821528013
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.Huang, Ruili; Southall, Noel; Wang, Yuhong; Yasgar, Adam; Shinn, Paul; Jadhav, Ajit; Nguyen, Dac-Trung; Austin, Christopher PScience translational medicine2011 Apr 2780ps1621525397
Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling.Boutin, Alisa; Allen, Michael D; Geras-Raaka, Elizabeth; Huang, Wenwei; Neumann, Susanne; Gershengorn, Marvin CMolecular pharmacology2011 Aug240-621525174
Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.Lopez-Vallejo, Fabian; Caulfield, Thomas; Martinez-Mayorga, Karina; Giulianotti, Marc A; Nefzi, Adel; Houghten, Richard A; Medina-Franco, Jose LCombinatorial chemistry & high throughput screening2011 Jul475-8721521151
Active-site-directed chemical tools for profiling mitochondrial Lon protease.Fishovitz, Jennifer; Li, Min; Frase, Hilary; Hudak, Jason; Craig, Sandra; Ko, Kristin; Berdis, Anthony J; Suzuki, Carolyn K; Lee, IreneACS chemical biology2011 Aug 19781-821520912
The nitrosocarbonyl hetero-Diels-Alder reaction as a useful tool for organic syntheses.Bodnar, Brian S; Miller, Marvin JAngewandte Chemie (International ed. in English)2011 Jun 145630-4721520360
Magnetomotive molecular nanoprobes.John, Renu; Boppart, Stephen ACurrent medicinal chemistry20112103-1421517766
Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.Leclair, Christopher A; Boxer, Matthew B; Thomas, Craig J; Maloney, David JTetrahedron letters2010 Dec 296852-685521516235
Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.Chigaev, Alexandre; Smagley, Yelena; Zhang, Yinan; Waller, Anna; Haynes, Mark K; Amit, Or; Wang, Wei; Larson, Richard S; Sklar, Larry AThe Journal of biological chemistry2011 Jun 1020375-8621515675
Amphiregulin exosomes increase cancer cell invasion.Higginbotham, James N; Demory Beckler, Michelle; Gephart, Jonathan D; Franklin, Jeffrey L; Bogatcheva, Galina; Kremers, Gert-Jan; Piston, David W; Ayers, Gregory D; McConnell, Russell E; Tyska, Matthew J; Coffey, Robert JCurrent biology : CB2011 May 10779-8621514161
Facile and unified approach to skeletally diverse, privileged scaffolds.Sahn, James J; Su, Justin Y; Martin, Stephen FOrganic letters2011 May 202590-321513290
Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.Cencic, Regina; Desforges, Marc; Hall, David R; Kozakov, Dima; Du, Yuhong; Min, Jaeki; Dingledine, Raymond; Fu, Haian; Vajda, Sandor; Talbot, Pierre J; Pelletier, JerryJournal of virology2011 Jul6381-921507972
Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.Bobkova, Ekaterina V; Liu, Wallace H; Colayco, Sharon; Rascon, Justin; Vasile, Stefan; Gasior, Carlton; Critton, David A; Chan, Xochella; Dahl, Russell; Su, Ying; Sergienko, Eduard; Chung, Thomas D Y; Mustelin, Tomas; Page, Rebecca; Tautz, LutzACS medicinal chemistry letters2011 Feb113-11821503265
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.Huryn, Donna M; Brodsky, Jeffrey L; Brummond, Kay M; Chambers, Peter G; Eyer, Benjamin; Ireland, Alex W; Kawasumi, Masaoki; Laporte, Matthew G; Lloyd, Kayla; Manteau, Baptiste; Nghiem, Paul; Quade, Bettina; Seguin, Sandlin P; Wipf, PeterProceedings of the National Academy of Sciences of the United States of America2011 Apr 266757-6221502524
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.Solt, Laura A; Kumar, Naresh; Nuhant, Philippe; Wang, Yongjun; Lauer, Janelle L; Liu, Jin; Istrate, Monica A; Kamenecka, Theodore M; Roush, William R; Vidovic, Dusica; Schurer, Stephan C; Xu, Jihong; Wagoner, Gail; Drew, Paul D; Griffin, Patrick R; BurrisNature2011 Apr 28491-421499262
Discovery of new antimalarial chemotypes through chemical methodology and library development.Brown, Lauren E; Chih-Chien Cheng, Ken; Wei, Wan-Guo; Yuan, Pingwei; Dai, Peng; Trilles, Richard; Ni, Feng; Yuan, Jing; MacArthur, Ryan; Guha, Rajarshi; Johnson, Ronald L; Su, Xin-zhuan; Dominguez, Melissa M; Snyder, John K; Beeler, Aaron B; Schaus, Scott E; Inglese, James; Porco Jr, John AProceedings of the National Academy of Sciences of the United States of America2011 Apr 266775-8021498685
Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells.Zhou, Kejin; Wang, Yiguang; Huang, Xiaonan; Luby-Phelps, Katherine; Sumer, Baran D; Gao, JinmingAngewandte Chemie (International ed. in English)2011 Jun 276109-1421495146
Noncanonical TGFýý signaling contributes to aortic aneurysm progression in Marfan syndrome mice.Holm, Tammy M; Habashi, Jennifer P; Doyle, Jefferson J; Bedja, Djahida; Chen, YiChun; van Erp, Christel; Lindsay, Mark E; Kim, David; Schoenhoff, Florian; Cohn, Ronald D; Loeys, Bart L; Thomas, Craig J; Patnaik, Samarjit; Marugan, Juan J; Judge, Daniel P; Dietz, Harry CScience (New York, N.Y.)2011 Apr 15358-6121493862
Phosphine-catalyzed ýý'-umpolung addition of nucleophiles to activated ýý-alkyl allenes.Martin, Tioga J; Vakhshori, Venus G; Tran, Yang S; Kwon, OhyunOrganic letters2011 May 202586-921491870
Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera.Mevers, Emily; Liu, Wei-Ting; Engene, Niclas; Mohimani, Hosein; Byrum, Tara; Pevzner, Pavel A; Dorrestein, Pieter C; Spadafora, Carmenza; Gerwick, William HJournal of natural products2011 May 27928-3621488639
Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria.Fiamegos, Yiannis C; Kastritis, Panagiotis L; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M J J; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael R; Tegos, George PPloS one2011e1812721483731
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, Paul A; Wilson, J Anthony; Dancik, Vlado; Muller, Sandrine; Carrinski, Hyman A; Wagner, Bridget K; Koehler, Angela N; Schreiber, Stuart LProceedings of the National Academy of Sciences of the United States of America2011 Apr 266817-2221482810
A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.Johnson, Ronald L; Hwang, Jong Yeon; Arnold, Leggy A; Huang, Ruili; Wichterman, Jennifer; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Guy, R Kiplin; Huang, WenweiJournal of biomolecular screening2011 Jul618-2721482722
An improved cerulean fluorescent protein with enhanced brightness and reduced reversible photoswitching.Markwardt, Michele L; Kremers, Gert-Jan; Kraft, Catherine A; Ray, Krishanu; Cranfill, Paula J C; Wilson, Korey A; Day, Richard N; Wachter, Rebekka M; Davidson, Michael W; Rizzo, Mark APloS one2011e1789621479270
Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy.Gramling, S; Rogers, C; Liu, G; Reisman, DOncogene2011 Jul 213289-9421478905
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Zhang, Jun; Chalmers, Michael J; Stayrook, Keith R; Burris, Lorri L; Wang, Yongjun; Busby, Scott A; Pascal, Bruce D; Garcia-Ordonez, Ruben D; Bruning, John B; Istrate, Monica A; Kojetin, Douglas J; Dodge, Jeffrey A; Burris, Thomas P; Griffin, Patrick RNature structural & molecular biology2011 May556-6321478866
Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing.Kaya, Mehmet; Feingold, Steven; Hettiarachchi, Kanaka; Lee, Abraham P; Dayton, Paul ABubble science engineering and technology2010 Dec33-4021475641
Microbial efflux pump inhibition: tactics and strategies.Tegos, George P; Haynes, Mark; Strouse, J Jacob; Khan, Mohiuddin Md T; Bologa, Cristian G; Oprea, Tudor I; Sklar, Larry ACurrent pharmaceutical design20111291-30221470111
Importazole, a small molecule inhibitor of the transport receptor importin-ýý.Soderholm, Jonathan F; Bird, Stephen L; Kalab, Petr; Sampathkumar, Yasaswini; Hasegawa, Keisuke; Uehara-Bingen, Michael; Weis, Karsten; Heald, RebeccaACS chemical biology2011 Jul 15700-821469738
A facile surfactant critical micelle concentration determination.Cai, Lifeng; Gochin, Miriam; Liu, KeliangChemical communications (Cambridge, England)2011 May 215527-921468398
High Throughput Synthesis of 2,3,6-Trisubstituted-5,6-Dihydroimidazo[2,1-b]thiazole Derivatives.Li, Yangmei; Giulianotti, Marc; Houghten, Richard ATetrahedron letters2011 Feb 9696-69821461055
Three-component synthesis of cyclic enaminones via ketene cyclization.Seki, Hajime; Georg, Gunda IOrganic letters2011 May 62147-921456588
Energy transfer cassettes in silica nanoparticles target intracellular organelles.Jose, Jiney; Loudet, Aurore; Ueno, Yuichiro; Wu, Liangxing; Chen, Hsiang-Yun; Son, Dong Hee; Barhoumi, Rola; Burghardt, Robert; Burgess, KevinOrganic & biomolecular chemistry2011 May 213871-721455504
Assay of the multiple energy-producing pathways of mammalian cells.Bochner, Barry R; Siri, Mark; Huang, Richard H; Noble, Shawn; Lei, Xiang-He; Clemons, Paul A; Wagner, Bridget KPloS one2011e1814721455318
Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines.Pepe, Antonella; Pamment, Michael; Georg, Gunda I; Malhotra, Sanjay VThe Journal of organic chemistry2011 May 63527-3021452823
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.Moura-Letts, Gustavo; Diblasi, Christine M; Bauer, Renato A; Tan, Derek SProceedings of the National Academy of Sciences of the United States of America2011 Apr 266745-5021451137
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).Rosenthal, Andrew S; Tanega, Cordelle; Shen, Min; Mott, Bryan T; Bougie, James M; Nguyen, Dac-Trung; Misteli, Tom; Auld, Douglas S; Maloney, David J; Thomas, Craig JBioorganic & medicinal chemistry letters2011 May 153152-821450467
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.Salvador, Lilibeth A; Biggs, Jason S; Paul, Valerie J; Luesch, HendrikJournal of natural products2011 May 27917-2721446699
Actions of a picomolar short-acting S1Pýýý agonist in S1Pýýý-eGFP knock-in mice.Cahalan, Stuart M; Gonzalez-Cabrera, Pedro J; Sarkisyan, Gor; Nguyen, Nhan; Schaeffer, Marie-Therese; Huang, Liming; Yeager, Adam; Clemons, Bryan; Scott, Fiona; Rosen, HughNature chemical biology2011 May254-621445057
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.Chu, Wenhua; Rothfuss, Justin; Zhou, Dong; Mach, Robert HBioorganic & medicinal chemistry letters2011 Apr 152192-721441025
Highly substituted lactone/ester-containing furan library by the palladium-catalyzed carbonylation of hydroxyl-substituted 3-iodofurans.Cho, Chul-Hee; Larock, Richard CACS combinatorial science2011 May 9272-921434604
Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria.Chlipala, George; Mo, Shunyan; Carcache de Blanco, Esperanza J; Ito, Aiko; Bazarek, Stanley; Orjala, JimmyPharmaceutical biology2009 Jan53-6021430788
The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.Seyedsayamdost, Mohammad R; Case, Rebecca J; Kolter, Roberto; Clardy, JonNature chemistry2011 Apr331-521430694
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.Huang, Fei; Motlekar, Nuzhat A; Burgwin, Chelsea M; Napper, Andrew D; Diamond, Scott L; Mazin, Alexander VACS chemical biology2011 Jun 17628-3521428443
Chemistry and biology of macrolide antiparasitic agents.Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R; Boothroyd, John C; Khosla, ChaitanJournal of medicinal chemistry2011 Apr 282792-80421428405
Functional model of metabolite gating by human voltage-dependent anion channel 2.Bauer, Andras J; Gieschler, Simone; Lemberg, Kathryn M; McDermott, Ann E; Stockwell, Brent RBiochemistry2011 May 33408-1021425834
Hybrid top-down and bottom-up fabrication approach for wafer-scale plasmonic nanoplatforms.Dhawan, Anuj; Du, Yan; Batchelor, Dale; Wang, Hsin-Neng; Leonard, Donovon; Misra, Veena; Ozturk, Mehmet; Gerhold, Michael D; Vo-Dinh, TuanSmall (Weinheim an der Bergstrasse, Germany)2011 Mar 21727-3121425456
Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines.Markina, Nataliya A; Mancuso, Raffaella; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard CACS combinatorial science2011 May 9265-7121410207
Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Ledeboer, Nathan; Huang, Sheng-Xiong; Rajski, Scott R; Kron, Michael; Shen, BenOrganic letters2011 Apr 152034-721405052
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.Bachovchin, Daniel A; Mohr, Justin T; Speers, Anna E; Wang, Chu; Berlin, Jacob M; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Schurer, Stephan C; Nomura, Daniel K; Rosen, Hugh; Fu, Gregory C; Cravatt, Benjamin FProceedings of the National Academy of Sciences of the United States of America2011 Apr 266811-621398589
A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.Du, Yuhong; Nikolovska-Coleska, Zaneta; Qui, Min; Li, Lian; Lewis, Iestyn; Dingledine, Raymond; Stuckey, Jeanne A; Krajewski, Krzysztof; Roller, Peter P; Wang, Shaomeng; Fu, HaianAssay and drug development technologies2011 Aug382-9321395401
One-pot synthesis of 2-amino-indole-3-carboxamide and analogous.Wang, Kan; Herdtweck, Eberhardt; Domling, AlexanderACS combinatorial science2011 Mar 14140-621395342
Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging.Dhawan, A; Duval, A; Nakkach, M; Barbillon, G; Moreau, J; Canva, M; Vo-Dinh, TNanotechnology2011 Apr 2216530121393822
Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms.LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D; Diamond, Scott L; Lewis, KimThe Journal of antimicrobial chemotherapy2011 Apr820-621393183
Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions.Uchida, Masaki; Kosuge, Hisanori; Terashima, Masahiro; Willits, Deborah A; Liepold, Lars O; Young, Mark J; McConnell, Michael V; Douglas, TrevorACS nano2011 Apr 262493-50221391720
Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines.Chavez, Kathryn J; Feng, Xiaohong; Flanders, James A; Rodriguez, Eloy; Schroeder, Frank CJournal of natural products2011 May 271293-721391655
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, Jen Q; Lewis, Michael C; Ketterman, Josh K; Clore, Elizabeth L; Riley, Misha; Richards, Keenan R; Berry-Scott, Erin; Liu, Xiulin; Wagner, Florence F; Holson, Edward B; Neve, Rachael L; Biechele, Travis L; Moon, Randall T; Scolnick, Edward M; PetrysheNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011 Jun1397-41121389981
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.Evdokimov, Nikolai M; Van Slambrouck, Severine; Heffeter, Petra; Tu, Lee; Le Calve, Benjamin; Lamoral-Theys, Delphine; Hooten, Carla J; Uglinskii, Pavel Y; Rogelj, Snezna; Kiss, Robert; Steelant, Wim F A; Berger, Walter; Yang, Jeremy J; Bologa, Cristian GJournal of medicinal chemistry2011 Apr 142012-2121388138
A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.Qiao, Kangjian; Zhou, Hui; Xu, Wei; Zhang, Wenjun; Garg, Neil; Tang, YiOrganic letters2011 Apr 11758-6121384820
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).Ghoreschi, Kamran; Jesson, Michael I; Li, Xiong; Lee, Jamie L; Ghosh, Sarbani; Alsup, Jason W; Warner, James D; Tanaka, Masao; Steward-Tharp, Scott M; Gadina, Massimo; Thomas, Craig J; Minnerly, John C; Storer, Chad E; LaBranche, Timothy P; Radi, Zaher A; Dowty, Martin E; Head, Richard D; Meyer, Debra M; Kishore, Nandini; O'Shea, John JJournal of immunology (Baltimore, Md. : 1950)2011 Apr 14234-4321383241
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.Chou, Tsui-Fen; Brown, Steve J; Minond, Dmitriy; Nordin, Brian E; Li, Kelin; Jones, Amanda C; Chase, Peter; Porubsky, Patrick R; Stoltz, Brian M; Schoenen, Frank J; Patricelli, Matthew P; Hodder, Peter; Rosen, Hugh; Deshaies, Raymond JProceedings of the National Academy of Sciences of the United States of America2011 Mar 224834-921383145
Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity.Cruz, Daniel; Wang, Zhiming; Kibbie, Jon; Modlin, Robert; Kwon, OhyunProceedings of the National Academy of Sciences of the United States of America2011 Apr 266769-7421383121
Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.Busby, Scott A; Kumar, Naresh; Kuruvilla, Dana S; Istrate, Monica A; Conkright, Juliana J; Wang, Yongjun; Kamenecka, Theodore M; Cameron, Michael D; Roush, William R; Burris, Thomas P; Griffin, Patrick RACS chemical biology2011 Jun 17618-2721381756
Marinobufagenin levels in preeclamptic patients: a preliminary report.Agunanne, Enoch; Horvat, Darijana; Harrison, Recherael; Uddin, M Nasir; Jones, Richard; Kuehl, Thomas J; Ghanem, Daad Abi; Berghman, Luc R; Lai, Xinzhong; Li, Jing; Romo, Daniel; Puschett, Jules BAmerican journal of perinatology2011 Aug509-1421380994
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.Deng, Xianming; Dzamko, Nicolas; Prescott, Alan; Davies, Paul; Liu, Qingsong; Yang, Qingkai; Lee, Jiing-Dwan; Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Alessi, Dario R; Gray, Nathanael SNature chemical biology2011 Apr203-521378983
The binding of fluorophores to proteins depends on the cellular environment.Kim, Yun Kyung; Lee, Jun-Seok; Bi, Xuezhi; Ha, Hyung-Ho; Ng, Shin Hui; Ahn, Young-hoon; Lee, Jae-Jung; Wagner, Bridget K; Clemons, Paul A; Chang, Young-TaeAngewandte Chemie (International ed. in English)2011 Mar 142761-321370369
Discovering small-molecule estrogen receptor ýý/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.Sun, Aiming; Moore, Terry W; Gunther, Jillian R; Kim, Mi-Sun; Rhoden, Eric; Du, Yuhong; Fu, Haian; Snyder, James P; Katzenellenbogen, John AChemMedChem2011 Apr 4654-6621365764
The effect of inhaled gases on ultrasound contrast agent longevity in vivo.Itani, Malak; Mattrey, Robert FMolecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging2012 Feb40-621365328
Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery.Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon; Currie, Cameron RPloS one2011e1676321364940
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.Xia, Menghang; Shahane, Sampada A; Huang, Ruili; Titus, Steven A; Shum, Enoch; Zhao, Yong; Southall, Noel; Zheng, Wei; Witt, Kristine L; Tice, Raymond R; Austin, Christopher PToxicology and applied pharmacology2011 May 1250-821362439
Equilibrium between a vinylogous ylide and a phosphonium dienolate zwitterion: vinylogous Wittig olefination versus vinylogous aldol-type reaction.Khong, San N; Tran, Yang S; Kwon, OhyunTetrahedron2010 Jun4760-476821359169
Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.Siddiquee, Khandaker; Hampton, Jessica; Khan, Susan; Zadory, Dan; Gleaves, Linda; Vaughan, Douglas E; Smith, Layton HJournal of hypertension2011 Apr724-3121358420
RNA localization in bacteria.Keiler, Kenneth CCurrent opinion in microbiology2011 Apr155-921354362
Photoscattering effect in supercontinuum-generating photonic crystal fiber.Tu, H; Marks, D L; Jiang, Z; Boppart, S AApplied physics letters2008 Feb 1121350681
Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.Chou, Tsui-Fen; Deshaies, Raymond JThe Journal of biological chemistry2011 May 1316546-5421343295
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.Broccatelli, Fabio; Carosati, Emanuele; Neri, Annalisa; Frosini, Maria; Goracci, Laura; Oprea, Tudor I; Cruciani, GabrieleJournal of medicinal chemistry2011 Mar 241740-5121341745
Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam.Gunasekera, Sarath P; Owle, Chivas S; Montaser, Rana; Luesch, Hendrik; Paul, Valerie JJournal of natural products2011 Apr 25871-621341718
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Stanford, Stephanie M; Krishnamurthy, Divya; Falk, Matthew D; Messina, Rossella; Debnath, Bikash; Li, Sheng; Liu, Tong; Kazemi, Roza; Dahl, Russell; He, Yantao; Yu, Xiao; Chan, Andrew C; Zhang, Zhong-Yin; Barrios, Amy M; Woods Jr, Virgil L; Neamati, NouriJournal of medicinal chemistry2011 Mar 241640-5421341673
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.Popowicz, Grzegorz M; Domling, Alexander; Holak, Tad AAngewandte Chemie (International ed. in English)2011 Mar 142680-821341346
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluýýý.Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey RACS combinatorial science2011 Mar 14159-6521338051
A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells.Li, Hui-Fang; Keeton, Adam; Vitolo, Michele; Maddox, Clinton; Rasmussen, Lynn; Hobrath, Judith; White, E Lucille; Park, Ben Ho; Piazza, Gary A; Kim, Jung-Sik; Waldman, ToddJournal of biomolecular screening2011 Apr383-9321335596
Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT).Tomlinson, Ian D; Iwamoto, Hideki; Blakely, Randy D; Rosenthal, Sandra JBioorganic & medicinal chemistry letters2011 Mar 151678-8221334895
Large-scale analysis of UPR-mediated apoptosis in human cells.Fribley, Andrew M; Miller, Justin R; Reist, Tyler E; Callaghan, Michael U; Kaufman, Randal JMethods in enzymology201157-7121329794
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.Chalmers, Michael J; Busby, Scott A; Pascal, Bruce D; West, Graham M; Griffin, Patrick RExpert review of proteomics2011 Feb43-5921329427
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.Liu, Qingsong; Wang, Jinhua; Kang, Seong A; Thoreen, Carson C; Hur, Wooyoung; Ahmed, Tausif; Sabatini, David M; Gray, Nathanael SJournal of medicinal chemistry2011 Mar 101473-8021322566
The evolving field of imaging mass spectrometry and its impact on future biological research.Watrous, Jeramie D; Alexandrov, Theodore; Dorrestein, Pieter CJournal of mass spectrometry : JMS2011 Feb209-2221322093
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.Hwang, Jong Yeon; Huang, Wenwei; Arnold, Leggy A; Huang, Ruili; Attia, Ramy R; Connelly, Michele; Wichterman, Jennifer; Zhu, Fangyi; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Johnson, Ronald L; Guy, R KiplinThe Journal of biological chemistry2011 Apr 811895-90821321127
Vpr-host interactions during HIV-1 viral life cycle.Zhao, Richard Y; Li, Ge; Bukrinsky, Michael IJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2011 Jun216-2921318276
Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones.Fenster, Erik; Long, Toby R; Zang, Qin; Hill, David; Neuenswander, Benjamin; Lushington, Gerald H; Zhou, Aihua; Santini, Conrad; Hanson, Paul RACS combinatorial science2011 May 9244-5021309582
Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis.Choi, Jayoung; Mouillesseaux, Kevin; Wang, Zhiming; Fiji, Hannah D G; Kinderman, Sape S; Otto, Georg W; Geisler, Robert; Kwon, Ohyun; Chen, Jau-NianDevelopment (Cambridge, England)2011 Mar1173-8121307094
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.Gao, Xue; Chooi, Yit-Heng; Ames, Brian D; Wang, Peng; Walsh, Christopher T; Tang, YiJournal of the American Chemical Society2011 Mar 22729-4121299212
Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents.John, Renu; Nguyen, Freddy T; Kolbeck, Kenneth J; Chaney, Eric J; Marjanovic, Marina; Suslick, Kenneth S; Boppart, Stephen AMolecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging2012 Feb17-2421298354
Development of an HTS-compatible assay for discovery of RORýý modulators using AlphaScreenýý technology.Istrate, Monica A; Spicer, Timothy P; Wang, Yan; Bernard, Jerrold A; Helvering, Leah M; Bocchinfuso, Wayne P; Richardson, Timothy I; Zink, Richard; Kumar, Naresh; Montrose-Rafizadeh, Chahrzad; Dodge, Jeffrey; Hodder, Peter; Griffin, Patrick RJournal of biomolecular screening2011 Feb183-9121297105
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.Yuan, Peixiong; Tragon, Tyson; Xia, Menghang; Leclair, Christopher A; Skoumbourdis, Amanda P; Zheng, Wei; Thomas, Craig J; Huang, Ruili; Austin, Christopher P; Chen, Guang; Guitart, XavierPharmacology, biochemistry, and behavior2011 May349-5521296104
Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.Lopez-Vallejo, Fabian; Nefzi, Adel; Bender, Andreas; Owen, John R; Nabney, Ian T; Houghten, Richard A; Medina-Franco, Jose LChemical biology & drug design2011 May328-4221294850
Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles.Avila, Belem; Solano, Danielle M; Haddadin, Makhluf J; Kurth, Mark JOrganic letters2011 Mar 41060-321294577
Chiral kinase inhibitors.Jiang, Jian-kang; Shen, Min; Thomas, Craig J; Boxer, Mathew BCurrent topics in medicinal chemistry2011800-921291394
CEST MRI reporter genes.Liu, Guanshu; Bulte, Jeff W M; Gilad, Assaf AMethods in molecular biology (Clifton, N.J.)2011271-8021279607
Amide proton transfer imaging of the human brain.Zhou, JinyuanMethods in molecular biology (Clifton, N.J.)2011227-3721279604
Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validations.Khemtong, Chalermchai; Togao, Osamu; Ren, Jimin; Kessinger, Chase W; Takahashi, Masaya; Sherry, A Dean; Gao, JinmingJournal of magnetic resonance (San Diego, Calif. : 1997)2011 Mar53-6021277813
Synthesis and diversification of 1,2,3-triazole-fused 1,4-benzodiazepine scaffolds.Donald, James R; Martin, Stephen FOrganic letters2011 Mar 4852-521275426
PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures.Huesa, Carmen; Yadav, Manisha C; Finnila, Mikko A J; Goodyear, Simon R; Robins, Simon P; Tanner, K Elizabeth; Aspden, Richard M; Millan, Jose Luis; Farquharson, ColinBone2011 May 11066-7421272676
Defects in beta cell Caýý+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus.Benninger, R K P; Remedi, M S; Head, W S; Ustione, A; Piston, D W; Nichols, C GDiabetologia2011 May1087-9721271337
Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.Haushalter, Robert W; Filipp, Fabian V; Ko, Kwang-Seuk; Yu, Ricky; Opella, Stanley J; Burkart, Michael DACS chemical biology2011 May 20413-821268653
Pyrrole-based scaffolds for turn mimics.Ko, Eunhwa; Burgess, KevinOrganic letters2011 Mar 4980-321268601
Narrow groove plasmonic nano-gratings for surface plasmon resonance sensing.Dhawan, Anuj; Canva, Michael; Vo-Dinh, TuanOptics express2011 Jan 17787-81321263620
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.Prast-Nielsen, Stefanie; Dexheimer, Thomas S; Schultz, Lena; Stafford, William C; Cheng, Qing; Xu, Jianqiang; Jadhav, Ajit; Arner, Elias S J; Simeonov, AntonFree radical biology & medicine2011 May 11114-2321262347
Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa.Kwan, Jason Christopher; Meickle, Theresa; Ladwa, Dheran; Teplitski, Max; Paul, Valerie; Luesch, HendrikMolecular bioSystems2011 Apr1205-1621258753
An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.Zhu, Wenge; Lee, Chrissie Y; Johnson, Ronald L; Wichterman, Jennifer; Huang, Ruili; DePamphilis, Melvin LMolecular cancer research : MCR2011 Mar294-31021257818
A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids.Abi-Ghanem, Daad; Lai, Xinzhong; Berghman, Luc R; Horvat, Darijana; Li, Jing; Romo, Daniel; Uddin, Mohammad N; Kamano, Yoshiaki; Nogawa, Toshihiko; Xu, Jun-Ping; Pettit, George R; Puschett, Jules BJournal of immunoassay & immunochemistry201131-4621253968
New regulators of a high affinity Ca2+ influx system revealed through a genome-wide screen in yeast.Martin, D Christian; Kim, Hyemin; Mackin, Nancy A; Maldonado-Baez, Lymarie; Evangelista Jr, Carlos C; Beaudry, Veronica G; Dudgeon, Drew D; Naiman, Daniel Q; Erdman, Scott E; Cunningham, Kyle WThe Journal of biological chemistry2011 Mar 2510744-5421252230
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.Marugan, Juan J; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Westbroek, Wendy; Stubblefield, Barbara K; Sidransky, Ellen; Aungst, Ronald A; Lea, Wendy A; Simeonov, Anton; Leister, William; Austin, Christopher PJournal of medicinal chemistry2011 Feb 241033-5821250698
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases.Bekes, Miklos; Prudden, John; Srikumar, Tharan; Raught, Brian; Boddy, Michael N; Salvesen, Guy SThe Journal of biological chemistry2011 Mar 2510238-4721247896
Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R; Clardy, JonOrganic letters2011 Feb 18752-521247188
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.Engers, Darren W; Field, Julie R; Le, Uyen; Zhou, Ya; Bolinger, Julie D; Zamorano, Rocio; Blobaum, Anna L; Jones, Carrie K; Jadhav, Satyawan; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey RJournal of medicinal chemistry2011 Feb 241106-1021247167
Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats.Mullin, Lee; Gessner, Ryan; Kwan, James; Kaya, Mehmet; Borden, Mark A; Dayton, Paul AContrast media & molecular imaging2011 May-Jun126-3121246710
High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.Shu, Chih-Wen; Madiraju, Charitha; Zhai, Dayong; Welsh, Kate; Diaz, Paul; Sergienko, Eduard; Sano, Renata; Reed, John CJournal of biomolecular screening2011 Feb174-8221245471
Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity.Smith 3rd, Amos B; Kim, Won-SukProceedings of the National Academy of Sciences of the United States of America2011 Apr 266787-9221245309
APOBEC3G: a double agent in defense.Smith, Harold CTrends in biochemical sciences2011 May239-4421239176
Nano-fibrous tissue engineering scaffolds capable of growth factor delivery.Hu, Jiang; Ma, Peter XPharmaceutical research2011 Jun1273-8121234657
The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge.Dubberke, E R; Haslam, D B; Lanzas, C; Bobo, L D; Burnham, C-A D; Grohn, Y T; Tarr, P IZoonoses and public health2011 Feb4-2021223531
Label-Free Receptor Assays.Fang, YeDrug discovery today. Technologies2011e5-e1121221420
Helix 11 dynamics is critical for constitutive androstane receptor activity.Wright, Edward; Busby, Scott A; Wisecarver, Sarah; Vincent, Jeremy; Griffin, Patrick R; Fernandez, Elias JStructure (London, England : 1993)2011 Jan 1237-4421220114
A Java API for working with PubChem datasets.Southern, Mark R; Griffin, Patrick RBioinformatics (Oxford, England)2011 Mar 1741-221216779
Discovery of selective irreversible inhibitors for EGFR-T790M.Zhou, Wenjun; Ercan, Dalia; Janne, Pasi A; Gray, Nathanael SBioorganic & medicinal chemistry letters2011 Jan 15638-4321208802
Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.Hwang, Inkyu; Ki, DaLimFrontiers in bioscience : a journal and virtual library2011411-2121196178
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.Reid, Paul R; Bridges, Thomas M; Sheffler, Douglas J; Cho, Hyekyung P; Lewis, L Michelle; Days, Emily; Daniels, J Scott; Jones, Carrie K; Niswender, Colleen M; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael RBioorganic & medicinal chemistry letters2011 May 12697-70121194936
Oxidation of organotrifluoroborates via oxone.Molander, Gary A; Cavalcanti, Livia NThe Journal of organic chemistry2011 Jan 21623-3021192650
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.Cencic, Regina; Hall, David R; Robert, Francis; Du, Yuhong; Min, Jaeki; Li, Lian; Qui, Min; Lewis, Iestyn; Kurtkaya, Serdar; Dingledine, Ray; Fu, Haian; Kozakov, Dima; Vajda, Sandor; Pelletier, JerryProceedings of the National Academy of Sciences of the United States of America2011 Jan 181046-5121191102
Polycyclic compounds by Ugi-Pictet-Spengler sequence.Wang, Wei; Ollio, Sarah; Herdtweck, Eberhardt; Domling, AlexanderThe Journal of organic chemistry2011 Jan 21637-4421190371
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.Vang, Torkel; Xie, Yuli; Liu, Wallace H; Vidovic, Dusica; Liu, Yidong; Wu, Shuangding; Smith, Deborah H; Rinderspacher, Alison; Chung, Caty; Gong, Gangli; Mustelin, Tomas; Landry, Donald W; Rickert, Robert C; Schurer, Stephan C; Deng, Shi-Xian; Tautz, LutJournal of medicinal chemistry2011 Jan 27562-7121190368
Insights into the structural basis of RNA recognition by STAR domain proteins.Ryder, Sean P; Massi, FrancescaAdvances in experimental medicine and biology201037-5321189684
Titanium-catalyzed stereoselective synthesis of spirooxindole oxazolines.Badillo, Joseph J; Arevalo, Gary E; Fettinger, James C; Franz, Annaliese KOrganic letters2011 Feb 4418-2121186788
Activity-guided engineering of natural product carrier proteins.Worthington, Andrew S; Hur, Gene H; Burkart, Michael DMolecular bioSystems2011 Feb365-7021184004
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.Rico-Bautista, Elizabeth; Yang, Chih-Cheng; Lu, Lifang; Roth, Gregory P; Wolf, Dieter ABMC biology201015321182779
Universal peptidomimetics.Ko, Eunhwa; Liu, Jing; Perez, Lisa M; Lu, Genliang; Schaefer, Amber; Burgess, KevinJournal of the American Chemical Society2011 Jan 26462-7721182254
CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice.Wang, Qiang; Hillwig, Matthew L; Peters, Reuben JThe Plant journal : for cell and molecular biology2011 Jan87-9521175892
Spectroscopic optical coherence elastography.Adie, Steven G; Liang, Xing; Kennedy, Brendan F; John, Renu; Sampson, David D; Boppart, Stephen AOptics express2010 Dec 625519-3421164898
CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms.Chlipala, George E; Krunic, Aleksej; Mo, Shunyan; Sturdy, Megan; Orjala, JimmyJournal of chemical information and modeling2011 Jan 24171-8021162567
A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARýý partial agonists.Vidovic, Dusica; Busby, Scott A; Griffin, Patrick R; Schurer, Stephan CChemMedChem2011 Jan 394-10321162086
Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.Shun, Tong Ying; Lazo, John S; Sharlow, Elizabeth R; Johnston, Paul AJournal of biomolecular screening2011 Jan1-1421160066
Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-a-go-go related gene potassium channels.Zou, Beiyan; Yu, Haibo; Babcock, Joseph J; Chanda, Pritam; Bader, Joel S; McManus, Owen B; Li, MinAssay and drug development technologies2010 Dec743-5421158688
Cooperative epigenetic modulation by cancer amplicon genes.Rui, Lixin; Emre, N C Tolga; Kruhlak, Michael J; Chung, Hye-Jung; Steidl, Christian; Slack, Graham; Wright, George W; Lenz, Georg; Ngo, Vu N; Shaffer, Arthur L; Xu, Weihong; Zhao, Hong; Yang, Yandan; Lamy, Laurence; Davis, R Eric; Xiao, Wenming; Powell, John; Maloney, David; Thomas, Craig J; Moller, Peter; Rosenwald, Andreas; Ott, German; Muller-Hermelink, Hans Konrad; Savage, Kerry; Connors, Joseph M; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Weisenburger, Dennis D; Chan, Wing C; Gascoyne, Randy D; Levens, David; Staudt, Louis MCancer cell2010 Dec 14590-60521156283
Paramagnetic relaxation assisted docking of a small indole compound in the HIV-1 gp41 hydrophobic pocket.Gochin, Miriam; Zhou, Guangyan; Phillips, Aaron HACS chemical biology2011 Mar 18267-7421155611
The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis.Bugreev, Dmitry V; Pezza, Roberto J; Mazina, Olga M; Voloshin, Oleg N; Camerini-Otero, R Daniel; Mazin, Alexander VNature structural & molecular biology2011 Jan56-6021151113
Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam.Montaser, Rana; Abboud, Khalil A; Paul, Valerie J; Luesch, HendrikJournal of natural products2011 Jan 28109-1221138309
High content screening for non-classical peroxisome proliferators.Sexton, Jonathan Z; He, Qingping; Forsberg, Lawrence J; Brenman, Jay EInternational journal of high throughput screening2010 Jul127-14021132080
Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.Chigaev, Alexandre; Wu, Yang; Williams, D Bart; Smagley, Yelena; Sklar, Larry AThe Journal of biological chemistry2011 Feb 185455-6321131351
Modeling general proteostasis: proteome balance in health and disease.Roth, Daniela M; Balch, William ECurrent opinion in cell biology2011 Apr126-3421131189
Fabry disease - current treatment and new drug development.Motabar O, Sidransky E, Goldin E, Zheng W.Curr Chem Genomics2010 Jul 2350-621127742
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.King, Oliver N F; Li, Xuan Shirley; Sakurai, Masaaki; Kawamura, Akane; Rose, Nathan R; Ng, Stanley S; Quinn, Amy M; Rai, Ganesha; Mott, Bryan T; Beswick, Paul; Klose, Robert J; Oppermann, Udo; Jadhav, Ajit; Heightman, Tom D; Maloney, David J; Schofield, Christopher J; Simeonov, AntonPloS one2010e1553521124847
A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.Neumann, Susanne; Eliseeva, Elena; McCoy, Joshua G; Napolitano, Giorgio; Giuliani, Cesidio; Monaco, Fabrizio; Huang, Wenwei; Gershengorn, Marvin CThe Journal of clinical endocrinology and metabolism2011 Feb548-5421123444
Quantum dots for quantitative flow cytometry.Buranda, Tione; Wu, Yang; Sklar, Larry AMethods in molecular biology (Clifton, N.J.)201167-8421116979
Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline.Wipf, Peter; George, Kara MSynlett : accounts and rapid communications in synthetic organic chemistry2010 Mar 1644-64821116479
Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor.McCoy, Joshua G; Marugan, Juan J; Liu, Ke; Zheng, Wei; Southall, Noel; Huang, Wenwei; Heilig, Markus; Austin, Christopher PACS chemical neuroscience2010 Aug 18559-57421116448
Clearance (nee Rowland) concepts: a downdate and an update.Benet, Leslie ZJournal of pharmacokinetics and pharmacodynamics2010 Dec529-3921113650
A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization.Cho, Chul-Hee; Jung, Dai-Il; Larock, Richard CTetrahedron letters2010 Dec 156485-648821113432
PROBING CANCER SIGNALING WITH RESONANT WAVEGUIDE GRATING BIOSENSORS.Fang, YeExpert opinion on drug discovery2010 Dec1237-124821113317
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.Ju, Wei; Zhang, Meili; Jiang, Jian-kang; Thomas, Craig J; Oh, Unsong; Bryant, Bonita R; Chen, Jing; Sato, Noriko; Tagaya, Yutaka; Morris, John C; Janik, John E; Jacobson, Steven; Waldmann, Thomas ABlood2011 Feb 101938-4621106989
Encapsulated energy-transfer cassettes with extremely well resolved fluorescent outputs.Ueno, Yuichiro; Jose, Jiney; Loudet, Aurore; Perez-Bolivar, Cesar; Anzenbacher Jr, Pavel; Burgess, KevinJournal of the American Chemical Society2011 Jan 1251-521105708
A stabilizing influence: CAL PDZ inhibition extends the half-life of ýýF508-CFTR.Cushing, Patrick R; Vouilleme, Lars; Pellegrini, Maria; Boisguerin, Prisca; Madden, Dean RAngewandte Chemie (International ed. in English)2010 Dec 179907-1121105033
WebPK, a web-based tool for custom pharmacokinetic simulation.Srimani, Jaydeep; Moffitt, Richard A; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20101494-721096365
Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.Critton, David A; Tautz, Lutz; Page, RebeccaJournal of molecular biology2011 Jan 21619-2921094165
Identification of SR3335 (ML-176): a synthetic RORýý selective inverse agonist.Kumar, Naresh; Kojetin, Douglas J; Solt, Laura A; Kumar, K Ganesh; Nuhant, Philippe; Duckett, Derek R; Cameron, Michael D; Butler, Andrew A; Roush, William R; Griffin, Patrick R; Burris, Thomas PACS chemical biology2011 Mar 18218-2221090593
Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes.Yang, Jane Y; Karr, Jessica R; Watrous, Jeramie D; Dorrestein, Pieter CCurrent opinion in chemical biology2011 Feb79-8721087892
Quantitative reactivity profiling predicts functional cysteines in proteomes.Weerapana, Eranthie; Wang, Chu; Simon, Gabriel M; Richter, Florian; Khare, Sagar; Dillon, Myles B D; Bachovchin, Daniel A; Mowen, Kerri; Baker, David; Cravatt, Benjamin FNature2010 Dec 9790-521085121
High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements.Chen, Catherine Z; Kulakova, Liudmila; Southall, Noel; Marugan, Juan J; Galkin, Andrey; Austin, Christopher P; Herzberg, Osnat; Zheng, WeiAntimicrobial agents and chemotherapy2011 Feb667-7521078930
A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation.Ezzeddine, Nader; Chen, Jiandong; Waltenspiel, Bernhard; Burch, Brandon; Albrecht, Todd; Zhuo, Ming; Warren, William D; Marzluff, William F; Wagner, Eric JMolecular and cellular biology2011 Jan328-4121078872
Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?Johnston, Paul ACurrent opinion in chemical biology2011 Feb174-8221075044
Human ferritin cages for imaging vascular macrophages.Terashima, Masahiro; Uchida, Masaki; Kosuge, Hisanori; Tsao, Philip S; Young, Mark J; Conolly, Steven M; Douglas, Trevor; McConnell, Michael VBiomaterials2011 Feb1430-721074263
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.Niesen, Frank H; Schultz, Lena; Jadhav, Ajit; Bhatia, Chitra; Guo, Kunde; Maloney, David J; Pilka, Ewa S; Wang, Minghua; Oppermann, Udo; Heightman, Tom D; Simeonov, AntonPloS one2010e1371921072165
NMR-spectroscopic analysis of mixtures: from structure to function.Forseth, Ry R; Schroeder, Frank CCurrent opinion in chemical biology2011 Feb38-4721071261
Practical 4'-phosphopantetheine active site discovery from proteomic samples.Meier, Jordan L; Patel, Anand D; Niessen, Sherry; Meehan, Michael; Kersten, Roland; Yang, Jane Y; Rothmann, Michael; Cravatt, Benjamin F; Dorrestein, Pieter C; Burkart, Michael D; Bafna, VineetJournal of proteome research2011 Jan 7320-921067235
Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines.Haddadin, Makhluf J; Bou Zerdan, Raghida M; Kurth, Mark J; Fettinger, James COrganic letters2010 Dec 35502-521067220
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.Dorjsuren, Dorjbal; Kim, Daemyung; Maloney, David J; Wilson 3rd, David M; Simeonov, AntonNucleic acids research2011 Jane1121062821
Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen.Maddry, Joseph A; Chen, Xi; Jonsson, Colleen B; Ananthan, Subramaniam; Hobrath, Judith; Smee, Donald F; Noah, James W; Noah, Diana; Xu, Xiaolin; Jia, Fuli; Maddox, Clinton; Sosa, Melinda I; White, E Lucile; Severson, William EJournal of biomolecular screening2011 Jan73-8121059874
Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii.Krunic, Aleksej; Vallat, Armelle; Mo, Shunyan; Lantvit, Daniel D; Swanson, Steven M; Orjala, JimmyJournal of natural products2010 Nov 291927-3221058727
Metabolomics of urine for the assessment of microvesicular lipid accumulation in the liver following isoniazid exposure.Sumner, Susan J; Burgess, Jason P; Snyder, Rodney W; Popp, James A; Fennell, Timothy RMetabolomics : Official journal of the Metabolomic Society2010 Jun 1238-24921057652
Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.Pinto, Jose Renato; Reynaldo, Daniel P; Parvatiyar, Michelle S; Dweck, David; Liang, Jingsheng; Jones, Michelle A; Sorenson, Martha M; Potter, James DThe Journal of biological chemistry2011 Jan 141005-1321056975
Atomic-level characterization of the ensemble of the Aýý(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms.Sgourakis, Nikolaos G; Merced-Serrano, Myrna; Boutsidis, Christos; Drineas, Petros; Du, Zheming; Wang, Chunyu; Garcia, Angel EJournal of molecular biology2011 Jan 14570-8321056574
Emergent properties of proteostasis-COPII coupled systems in human health and disease.Routledge, Katy E; Gupta, Vijay; Balch, William EMolecular membrane biology2010 Nov385-9721054154
Identification and characterization of steroidogenic factor-1 inverse agonists.Doghman, Mabrouka; Madoux, Franck; Hodder, Peter; Lalli, EnzoMethods in enzymology20103-2321050908
Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling.Ashley, Jason W; McCoy, Erin M; Clements, Daniel A; Shi, Zhenqi; Chen, Taosheng; Feng, XuAssay and drug development technologies2011 Feb40-921050071
A high-throughput screening strategy to overcome virus instability.Rasmussen, Lynn; Maddox, Clinton; Moore, Blake P; Severson, William; White, E LucileAssay and drug development technologies2011 Apr184-9021050067
Identification of novel small molecule activators of nuclear factor-ýýB with neuroprotective action via high-throughput screening.Manuvakhova, Marina S; Johnson, Guyla G; White, Misti C; Ananthan, Subramaniam; Sosa, Melinda; Maddox, Clinton; McKellip, Sara; Rasmussen, Lynn; Wennerberg, Krister; Hobrath, Judith V; White, E Lucile; Maddry, Joseph A; Grimaldi, MaurizioJournal of neuroscience research2011 Jan58-7221046675
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.Kojetin, Douglas; Wang, Yongjun; Kamenecka, Theodore M; Burris, Thomas PACS chemical biology2011 Feb 18131-421043485
Two-step Hantzsch based macrocyclization approach for the synthesis of thiazole-containing cyclopeptides.Nefzi, Adel; Arutyunyan, Sergey; Fenwick, Jason EThe Journal of organic chemistry2010 Nov 197939-4121033717
Applicability domains for classification problems: Benchmarking of distance to models for Ames mutagenicity set.Sushko, Iurii; Novotarskyi, Sergii; Korner, Robert; Pandey, Anil Kumar; Cherkasov, Artem; Li, Jiazhong; Gramatica, Paola; Hansen, Katja; Schroeter, Timon; Muller, Klaus-Robert; Xi, Lili; Liu, Huanxiang; Yao, Xiaojun; Oberg, Tomas; Hormozdiari, Farhad; DaoJournal of chemical information and modeling2010 Dec 272094-11121033656
A rapid and efficient route to benzazole heterocycles.Carpenter, Richard D; Kurth, Mark JNature protocols2010 Nov1731-621030949
Proteostasis strategies for restoring alpha1-antitrypsin deficiency.Bouchecareilh, Marion; Conkright, Juliana J; Balch, William EProceedings of the American Thoracic Society2010 Nov415-2221030523
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in ýý-cells.Kaufman, R J; Back, S H; Song, B; Han, J; Hassler, JDiabetes, obesity & metabolism2010 Oct99-10721029306
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.Sedykh, Alexander; Zhu, Hao; Tang, Hao; Zhang, Liying; Richard, Ann; Rusyn, Ivan; Tropsha, AlexanderEnvironmental health perspectives2011 Mar364-7020980217
The dopamine metabolite 3-methoxytyramine is a neuromodulator.Sotnikova, Tatyana D; Beaulieu, Jean-Martin; Espinoza, Stefano; Masri, Bernard; Zhang, Xiaodong; Salahpour, Ali; Barak, Larry S; Caron, Marc G; Gainetdinov, Raul RPloS one2010e1345220976142
Alkylation of the tumor suppressor PTEN activates Akt and ýý-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.Covey, Tracy M; Edes, Kornelia; Coombs, Gary S; Virshup, David M; Fitzpatrick, Frank APloS one2010e1354520975834
Identification of clinically used drugs that activate pregnane X receptors.Shukla, Sunita J; Sakamuru, Srilatha; Huang, Ruili; Moeller, Timothy A; Shinn, Paul; Vanleer, Danielle; Auld, Douglas S; Austin, Christopher P; Xia, MenghangDrug metabolism and disposition: the biological fate of chemicals2011 Jan151-920966043
Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.Mo, Shunyan; Krunic, Aleksej; Santarsiero, Bernard D; Franzblau, Scott G; Orjala, JimmyPhytochemistry2010 Dec2116-2320965528
One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters.Herath, Ananda; Cosford, Nicholas D POrganic letters2010 Nov 195182-520964284
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs.Zhou, Hui; Qiao, Kangjian; Gao, Zhizeng; Vederas, John C; Tang, YiThe Journal of biological chemistry2010 Dec 3141412-2120961859
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.Hajjo, Rima; Grulke, Christopher M; Golbraikh, Alexander; Setola, Vincent; Huang, Xi-Ping; Roth, Bryan L; Tropsha, AlexanderJournal of medicinal chemistry2010 Nov 117573-8620958049
Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles.Seki, Hajime; Georg, Gunda IJournal of the American Chemical Society2010 Nov 1015512-320958040
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, Paul A; Bodycombe, Nicole E; Carrinski, Hyman A; Wilson, J Anthony; Shamji, Alykhan F; Wagner, Bridget K; Koehler, Angela N; Schreiber, Stuart LProceedings of the National Academy of Sciences of the United States of America2010 Nov 218787-9220956335
Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone.Mao, Yang; Xu, Xianzhong; Xu, Wei; Ishida, Yuko; Leal, Walter S; Ames, James B; Clardy, JonProceedings of the National Academy of Sciences of the United States of America2010 Nov 219102-720956299
Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.Zhang, Jun; Chalmers, Michael J; Stayrook, Keith R; Burris, Lorri L; Garcia-Ordonez, Ruben D; Pascal, Bruce D; Burris, Thomas P; Dodge, Jeffery A; Griffin, Patrick RStructure (London, England : 1993)2010 Oct 131332-4120947021
A disease-relevant high-content screening assay to identify anti-inflammatory compounds for use in cystic fibrosis.Giddings, Angela M; Maitra, RanganJournal of biomolecular screening2010 Dec1204-1020944057
Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies.Larson, Peder E Z; Hu, Simon; Lustig, Michael; Kerr, Adam B; Nelson, Sarah J; Kurhanewicz, John; Pauly, John M; Vigneron, Daniel BMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2011 Mar610-920939089
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.Saunders, Matthew J; Edwards, Bruce S; Zhu, Jingshu; Sklar, Larry A; Graves, Steven WCurrent protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.]2010 OctUnit 13.12.1-1720938917
Disorders of bone remodeling.Feng, Xu; McDonald, Jay MAnnual review of pathology2011121-4520936937
Synthesis of dihydrobenzisoxazoles by the [3 + 2] cycloaddition of arynes and oxaziridines.Kivrak, Arif; Larock, Richard CThe Journal of organic chemistry2010 Nov 57381-720936802
Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs.Marsolais, David; Yagi, Saiko; Kago, Tomoyuki; Leaf, Nora; Rosen, HughMolecular pharmacology2011 Jan61-820935081
Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1.Thompson, Scott; Messick, Troy; Schultz, David C; Reichman, Melvin; Lieberman, Paul MJournal of biomolecular screening2010 Oct1107-1520930215
A high-throughput, homogeneous, fluorescence polarization assay for inhibitors of hedgehog protein autoprocessing.Jiang, Shu-qin; Paulus, HenryJournal of biomolecular screening2010 Oct1082-720930213
Synthesis of 6- and 7-membered cyclic enaminones: scope and mechanism.Niphakis, Micah J; Turunen, Brandon J; Georg, Gunda IThe Journal of organic chemistry2010 Oct 156793-80520929269
Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.Daher, Racha; Coincon, Mathieu; Fonvielle, Matthieu; Gest, Petra M; Guerin, Marcelo E; Jackson, Mary; Sygusch, Jurgen; Therisod, MichelJournal of medicinal chemistry2010 Nov 117836-4220929256
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.Bhave, Gautam; Chauder, Brian A; Liu, Wen; Dawson, Eric S; Kadakia, Rishin; Nguyen, Thuy T; Lewis, L Michelle; Meiler, Jens; Weaver, C David; Satlin, Lisa M; Lindsley, Craig W; Denton, Jerod SMolecular pharmacology2011 Jan42-5020926757
Coupling of receptor conformation and ligand orientation determine graded activity.Bruning, John B; Parent, Alexander A; Gil, German; Zhao, Min; Nowak, Jason; Pace, Margaret C; Smith, Carolyn L; Afonine, Pavel V; Adams, Paul D; Katzenellenbogen, John A; Nettles, Kendall WNature chemical biology2010 Nov837-4320924370
Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Dolle, Roland E; Bourdonnec, Bertrand Le; Worm, Karin; Morales, Guillermo A; Thomas, Craig J; Zhang, WeiJournal of combinatorial chemistry2010 Nov 8765-80620923157
Two rings in them all: the labdane-related diterpenoids.Peters, Reuben JNatural product reports2010 Nov1521-3020890488
Chembench: a cheminformatics workbench.Walker, Theo; Grulke, Christopher M; Pozefsky, Diane; Tropsha, AlexanderBioinformatics (Oxford, England)2010 Dec 13000-120889496
Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase.Mousseau, G; Kota, S; Takahashi, V; Frick, D N; Strosberg, A DThe Journal of general virology2011 Jan101-1120881089
S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.Rolfe, Alan; Samarakoon, Thiwanka B; Klimberg, Sarra V; Brzozowski, Marek; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul RJournal of combinatorial chemistry2010 Nov 8850-420879738
Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.Tinsley, Heather N; Gary, Bernard D; Thaiparambil, Jose; Li, Nan; Lu, Wenyan; Li, Yonghe; Maxuitenko, Yulia Y; Keeton, Adam B; Piazza, Gary ACancer prevention research (Philadelphia, Pa.)2010 Oct1303-1320876730
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.Feng, Jianying; Petersen, Clark D; Coy, David H; Jiang, Jian-Kang; Thomas, Craig J; Pollak, Martin R; Wank, Stephen AProceedings of the National Academy of Sciences of the United States of America2010 Oct 1217791-620876097
Small molecule peptidomimetic inhibitors of importin ýý/ýý mediated nuclear transport.Ambrus, Geza; Whitby, Landon R; Singer, Eric L; Trott, Oleg; Choi, Euna; Olson, Arthur J; Boger, Dale L; Gerace, LarryBioorganic & medicinal chemistry2010 Nov 17611-2020869252
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Rai, Ganesha; Kenyon, Victor; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson, J Brian; Hoobler, Eric; Leister, William; Simeonov, Anton; Holman, Theodore R; Maloney, David JJournal of medicinal chemistry2010 Oct 287392-40420866075
Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS.Zhou, Guangchang; Yan, Xiaoliang; Wu, Ding; Kron, Stephen JBioconjugate chemistry2010 Oct 201917-2420860375
Diterpenoid biopolymers: new directions for renewable materials engineering.Hillwig, Matthew L; Mann, Francis M; Peters, Reuben JBiopolymers2011 Feb71-620857504
Integrating computational and mixture-based screening of combinatorial libraries.Yongye, Austin B; Pinilla, Clemencia; Medina-Franco, Jose L; Giulianotti, Marc A; Dooley, Colette T; Appel, Jon R; Nefzi, Adel; Scior, Thomas; Houghten, Richard A; Martinez-Mayorga, KarinaJournal of molecular modeling2011 Jun1473-8220853183
Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.Joyner, P Matthew; Liu, Jinman; Zhang, Zhijun; Merritt, Justin; Qi, Fengxia; Cichewicz, Robert HOrganic & biomolecular chemistry2010 Dec 215486-920852771
Fluorous diastereomeric mixture synthesis (FDMS) of hydantoin-fused hexahydrochromeno[4,3-b]pyrroles.Lu, Yimin; Geib, Steven J; Damodaran, Krishnan; Sui, Bin; Zhang, Zijuan; Curran, Dennis P; Zhang, WeiChemical communications (Cambridge, England)2010 Oct 287578-8020844802
Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain.Cao, Shugeng; Blodgett, Joshua A V; Clardy, JonOrganic letters2010 Oct 154652-420843016
Fluorine (19F) MRS and MRI in biomedicine.Ruiz-Cabello, Jesus; Barnett, Brad P; Bottomley, Paul A; Bulte, Jeff W MNMR in biomedicine2011 Feb114-2920842758
Computational systems chemical biology.Oprea, Tudor I; May, Elebeoba E; Leitao, Andrei; Tropsha, AlexanderMethods in molecular biology (Clifton, N.J.)2011459-8820838980
The ups and downs of structure-activity landscapes.Guha, RajarshiMethods in molecular biology (Clifton, N.J.)2011101-1720838965
Bioluminescence assay for detecting cell surface membrane protein expression.Kato, Mieko; Chiba, Tomoki; Li, Min; Hanyu, YoshiroAssay and drug development technologies2011 Feb31-920836709
Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery.Macrae, Calum AExpert opinion on drug discovery2010 Jul619-63220835353
Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation.Yao, Nianhuan; Fung, Gabriel; Malekan, Hamed; Ye, Long; Kurth, Mark J; Lam, Kit SCarbohydrate research2010 Oct 132277-8120832778
Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers.Gika, Helen G; Theodoridis, Georgios A; Earll, Mark; Snyder, Rodney W; Sumner, Susan J; Wilson, Ian DAnalytical chemistry2010 Oct 18226-3420828141
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae.Xu, Wei; Cai, Xiaolu; Jung, Michael E; Tang, YiJournal of the American Chemical Society2010 Oct 613604-720828130
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and ýý-arrestin2 with antinociceptive activity.Zhao, Pingwei; Sharir, Haleli; Kapur, Ankur; Cowan, Alan; Geller, Ellen B; Adler, Martin W; Seltzman, Herbert H; Reggio, Patricia H; Heynen-Genel, Susanne; Sauer, Michelle; Chung, Thomas D Y; Bai, Yushi; Chen, Wei; Caron, Marc G; Barak, Larry S; Abood, MaMolecular pharmacology2010 Oct560-820826425
Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research.Bierwolf, Jeanette; Lutgehetmann, Marc; Feng, Kai; Erbes, Johannes; Deichmann, Steffen; Toronyi, Eva; Stieglitz, Christina; Nashan, Bjoern; Ma, Peter X; Pollok, Joerg MBiotechnology and bioengineering2011 Jan141-5020824672
Imaging dynamic cellular events with quantum dots The bright future.Smith, Andrew M; Wen, Mary M; Nie, ShumingThe biochemist2010 Jun 11220824157
Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge.Gregas, Molly K; Yan, Fei; Scaffidi, Jonathan; Wang, Hsin-Neng; Vo-Dinh, TuanNanomedicine : nanotechnology, biology, and medicine2011 Feb115-2220817123
Identification of novel inhibitors of dietary lipid absorption using zebrafish.Clifton, Justin D; Lucumi, Edinson; Myers, Michael C; Napper, Andrew; Hama, Kotaro; Farber, Steven A; Smith 3rd, Amos B; Huryn, Donna M; Diamond, Scott L; Pack, MichaelPloS one2010e1238620811635
Emerging principles in protease-based drug discovery.Drag, Marcin; Salvesen, Guy SNature reviews. Drug discovery2010 Sep690-70120811381
Small molecule inhibitors of DNA repair nuclease activities of APE1.Wilson 3rd, David M; Simeonov, AntonCellular and molecular life sciences : CMLS2010 Nov3621-3120809131
Quantitative volumetric perfusion mapping of the microvasculature using contrast ultrasound.Feingold, Steven; Gessner, Ryan; Guracar, Ismayil M; Dayton, Paul AInvestigative radiology2010 Oct669-7420808232
A magnetic bead-based protein kinase assay with dual detection techniques.Zhou, Guangchang; Sylvester, Juliesta E; Wu, Ding; Veach, Darren R; Kron, Stephen JAnalytical biochemistry2011 Jan 15-1120807497
Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida.Salvador, Lilibeth A; Paul, Valerie J; Luesch, HendrikJournal of natural products2010 Sep 241606-920806908
Improving success by balanced critical evaluations of assay methods.Inglese J, Napper A, Auld D.Assay Drug Dev Technol2010 Aug120804419
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.Bridges, Thomas M; Kennedy, J Phillip; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig WBioorganic & medicinal chemistry letters2010 Oct 15617-2220801651
Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs.Dellai, Afef; Maricic, Igor; Kumar, Vipin; Arutyunyan, Sergey; Bouraoui, Abderrahman; Nefzi, AdelBioorganic & medicinal chemistry letters2010 Oct 15653-720801649
On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity.Derbal, Safa; Hensler, Mary; Fang, Weiqin; Nizet, Victor; Ghedira, Kamel; Nefzi, AdelBioorganic & medicinal chemistry letters2010 Oct 15701-420800485
Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones.Hammill, Jared T; Contreras-Garcia, Julia; Virshup, Aaron M; Beratan, David; Yang, Weitao; Wipf, PeterTetrahedron2010 Mar 315852-586220798897
Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum.Van Wagoner, Ryan M; Deeds, Jonathan R; Satake, Masayuki; Ribeiro, Anthony A; Place, Allen R; Wright, Jeffrey L CTetrahedron letters2008 Nov 36457-646120798789
Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.Sturdy, Megan; Krunic, Aleksej; Cho, Sanghyun; Franzblau, Scott; Orjala, JimmyJournal of natural products2010 Aug 271441-320795743
Structure and relative potency of several karlotoxins from Karlodinium veneficum.Van Wagoner, Ryan M; Deeds, Jonathan R; Tatters, Avery O; Place, Allen R; Tomas, Carmelo R; Wright, Jeffrey L CJournal of natural products2010 Aug 271360-520795740
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.Lavieri, Robert R; Scott, Sarah A; Selvy, Paige E; Kim, Kwangho; Jadhav, Satyawan; Morrison, Ryan D; Daniels, J Scott; Brown, H Alex; Lindsley, Craig WJournal of medicinal chemistry2010 Sep 236706-1920735042
Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORýý and RORýý.Wang, Yongjun; Kumar, Naresh; Nuhant, Philippe; Cameron, Michael D; Istrate, Monica A; Roush, William R; Griffin, Patrick R; Burris, Thomas PACS chemical biology2010 Nov 191029-3420735016
New insights into repeat instability: role of RNAýýýDNA hybrids.McIvor, Elizabeth I; Polak, Urszula; Napierala, MarekRNA biology2010 Sep-Oct551-820729633
Model-free drug-likeness from fragments.Ursu, Oleg; Oprea, Tudor IJournal of chemical information and modeling2010 Aug 231387-9420726597
Preparation of FRET reporters to support chemical probe development.Foley, Timothy L; Yasgar, Adam; Garcia, Christopher J; Jadhav, Ajit; Simeonov, Anton; Burkart, Michael DOrganic & biomolecular chemistry2010 Oct 214601-620725690
Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment.Martin, Michelle D; Kremers, Gert-Jan; Short, Kurt W; Rocheleau, Jonathan V; Xu, Lei; Piston, David W; Matrisian, Lynn M; Gorden, D LeeMolecular cancer research : MCR2010 Oct1319-2720724460
Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.Dadiboyena, Sureshbabu; Nefzi, AdelEuropean journal of medicinal chemistry2010 Nov4697-70720724040
Highly ýý-selective hydrolysis of ýý,ýý-epoxyalcohols using tetrabutylammonium fluoride.Mukerjee, Purba; Abid, Mohammed; Schroeder, Frank COrganic letters2010 Sep 173986-920722386
Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists.Letourneau JJ, Riviello CM, Li H, Cole AG, Ho KK, Zanetakos HA, Desai H, Zhao J, Auld DS, Napier SE, Thomson FJ, Goan KA, Morphy JR, Ohlmeyer MH, Webb ML.Bioorg Med Chem Lett2010 Sep 155394-720719508
Surface-enhanced Raman scattering detection and tracking of nanoprobes: enhanced uptake and nuclear targeting in single cells.Gregas, Molly K; Scaffidi, Jonathan P; Lauly, Benoit; Vo-Dinh, TuanApplied spectroscopy2010 Aug858-6620719048
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.Gianni, Davide; Taulet, Nicolas; Zhang, Hui; DerMardirossian, Celine; Kister, Jeremy; Martinez, Luis; Roush, William R; Brown, Steven J; Bokoch, Gary M; Rosen, HughACS chemical biology2010 Oct 15981-9320715845
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides.Ullah, Farman; Samarakoon, Thiwanka; Rolfe, Alan; Kurtz, Ryan D; Hanson, Paul R; Organ, Michael GChemistry (Weinheim an der Bergstrasse, Germany)2010 Sep 2410959-6220715214
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.Shukla, Sunita J; Huang, Ruili; Austin, Christopher P; Xia, MenghangDrug discovery today2010 Dec997-100720708096
Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine.Niphakis, Micah J; Georg, Gunda IThe Journal of organic chemistry2010 Sep 36019-2220704319
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.Matthew, Susan; Salvador, Lilibeth A; Schupp, Peter J; Paul, Valerie J; Luesch, HendrikJournal of natural products2010 Sep 241544-5220704304
Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.Frymoyer, A; Shugarts, S; Browne, M; Wu, A H B; Frassetto, L; Benet, L ZClinical pharmacology and therapeutics2010 Oct540-720703222
Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors.Tang, M; Wierenga, K; Elsas, L J; Lai, KChemico-biological interactions2010 Dec 5376-8520696150
Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays.Horiuchi, Kurumi Y; Ma, HaichingMethods in molecular biology (Clifton, N.J.)2009161-7620694691
Chemical microarrays: a new tool for discovery enzyme inhibitors.Liang, Shuguang; Xu, Wei; Horiuchi, Kurumi Y; Wang, Yuan; Ma, HaichingMethods in molecular biology (Clifton, N.J.)2009149-6020694690
High-resolution, high-contrast ultrasound imaging using a prototype dual-frequency transducer: in vitro and in vivo studies.Gessner, Ryan; Lukacs, Marc; Lee, Mike; Cherin, Emmanuel; Foster, F Stuart; Dayton, Paul AIEEE transactions on ultrasonics, ferroelectrics, and frequency control2010 Aug1772-8120679006
Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.Jules, Joel; Ashley, Jason W; Feng, XuExpert opinion on therapeutic targets2010 Sep923-3420678025
Identification of a small molecule inhibitor of importin ýý mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.Hintersteiner, Martin; Ambrus, Geza; Bednenko, Janna; Schmied, Mario; Knox, Andrew J S; Meisner, Nicole-Claudia; Gstach, Hubert; Seifert, Jan-Marcus; Singer, Eric L; Gerace, Larry; Auer, ManfredACS chemical biology2010 Oct 15967-7920677820
Single-cell monitoring using fiberoptic nanosensors.Vo-Dinh, Tuan; Zhang, YanWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2011 Jan-Feb79-8520677238
Plasmonics nanoprobes: detection of single-nucleotide polymorphisms in the breast cancer BRCA1 gene.Wabuyele, Musundi B; Yan, Fei; Vo-Dinh, TuanAnalytical and bioanalytical chemistry2010 Sep729-3620676618
Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.Zhang, Xiaofei; Bertaso, Federica; Yoo, Jong W; Baumgartel, Karsten; Clancy, Sinead M; Lee, Van; Cienfuegos, Cynthia; Wilmot, Carly; Avis, Jacqueline; Hunyh, Truc; Daguia, Catherine; Schmedt, Christian; Noebels, Jeffrey; Jegla, TimothyNature neuroscience2010 Sep1056-820676103
High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.Sergienko, Eduard A; Millan, Jose LuisNature protocols2010 Aug1431-920671726
Structurally characterized luminescent lanthanide zinc carboxylate precursors for Ln-Zn-O nanomaterials.Boyle, Timothy J; Raymond, Rebecca; Boye, Daniel M; Ottley, Leigh Anna M; Lu, PingDalton transactions (Cambridge, England : 2003)2010 Sep 148050-6320664850
Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Dudgeon, Drew D; Shinde, Sunita N; Shun, Tong Ying; Lazo, John S; Strock, Christopher J; Giuliano, Kenneth A; Taylor, D Lansing; Johnston, Patricia A; Johnston, Paul AAssay and drug development technologies2010 Aug437-5820662736
An ultra-high throughput cell-based screen for wee1 degradation inhibitors.Madoux, Franck; Simanski, Scott; Chase, Peter; Mishra, Jitendra K; Roush, William R; Ayad, Nagi G; Hodder, PeterJournal of biomolecular screening2010 Sep907-1720660794
In vivo angiogenesis imaging of solid tumors by alpha(v)beta(3)-targeted, dual-modality micellar nanoprobes.Kessinger, Chase W; Khemtong, Chalermchai; Togao, Osamu; Takahashi, Masaya; Sumer, Baran D; Gao, JinmingExperimental biology and medicine (Maywood, N.J.)2010 Aug957-6520660096
Spontaneous formation of temperature-responsive assemblies by molecular recognition of a beta-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide).Zhang, Jianxiang; Feng, Kai; Cuddihy, Meghan; Kotov, Nicholas A; Ma, Peter XSoft matter2010 Aug 73669-367920657806
Gene expression associations with the growth inhibitory effects of small molecules on live cells: specificity of effects and uniformity of mechanisms.Shedden, Kerby; Yang, Yang; Rosania, GusStatistical analysis and data mining2009 Sep 1175-18520657799
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.Panakova, Daniela; Werdich, Andreas A; Macrae, Calum ANature2010 Aug 12874-820657579
Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening.Chung, Thomas D Y; Sergienko, Eduard; Millan, Jose LuisMolecules (Basel, Switzerland)2010 May3010-3720657462
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.Choi, Jang Hyun; Banks, Alexander S; Estall, Jennifer L; Kajimura, Shingo; Bostrom, Pontus; Laznik, Dina; Ruas, Jorge L; Chalmers, Michael J; Kamenecka, Theodore M; Bluher, Matthias; Griffin, Patrick R; Spiegelman, Bruce MNature2010 Jul 22451-620651683
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.Johnson, Douglas S; Weerapana, Eranthie; Cravatt, Benjamin FFuture medicinal chemistry2010 Jun949-6420640225
Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Dudgeon, Drew D; Shinde, Sunita; Hua, Yun; Shun, Tong Ying; Lazo, John S; Strock, Christopher J; Giuliano, Kenneth A; Taylor, D Lansing; Johnston, Patricia A; Johnston, Paul AJournal of biomolecular screening2010 Aug766-8220639499
Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water.Smith, Amos B; Atasoylu, Onur; Beshore, Douglas CSynlett : accounts and rapid communications in synthetic organic chemistry2009 Jan 12643-264620634903
Investigating the plasmonics of a dipole-excited silver nanoshell: Mie theory versus finite element method.Khoury, Christopher G; Norton, Stephen J; Vo-Dinh, TuanNanotechnology2010 Aug 631520320634565
Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties.Matthew, Susan; Ratnayake, Ranjala; Becerro, Mikel A; Ritson-Williams, Raphael; Paul, Valerie J; Luesch, HendrikMarine drugs20101803-1620631871
Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice.Fong, Cora J; Burgoon, Lyle D; Williams, Kurt J; Jones, A Daniel; Forgacs, Agnes L; Zacharewski, Timothy RJournal of molecular endocrinology2010 Sep161-7320628019
Molecules and methods for super-resolution imaging.Thompson, Michael A; Biteen, Julie S; Lord, Samuel J; Conley, Nicholas R; Moerner, W EMethods in enzymology201027-5920627152
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.Lipinski, Marta M; Hoffman, Greg; Ng, Aylwin; Zhou, Wen; Py, Benedicte F; Hsu, Emily; Liu, Xuxin; Eisenberg, Jason; Liu, Jun; Blenis, John; Xavier, Ramnik J; Yuan, JunyingDevelopmental cell2010 Jun 151041-5220627085
NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies.Weide, Timo; Saldanha, S Adrian; Minond, Dmitriy; Spicer, Timothy P; Fotsing, Joseph R; Spaargaren, Michael; Frere, Jean-Marie; Bebrone, Carine; Sharpless, K Barry; Hodder, Peter S; Fokin, Valery VACS medicinal chemistry letters2010 Jul 8150-15420625539
Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.Butler, Jeffrey D; Coffman, Keith C; Ziebart, Kristin T; Toney, Michael D; Kurth, Mark JChemistry (Weinheim an der Bergstrasse, Germany)2010 Aug 99002-520623732
mTOR Mediated Anti-Cancer Drug Discovery.Liu, Qingsong; Thoreen, Carson; Wang, Jinhua; Sabatini, David; Gray, Nathanael SDrug discovery today. Therapeutic strategies200947-5520622997
A mechanism based protein crosslinker for acyl carrier protein dehydratases.Meier, Jordan L; Haushalter, Robert W; Burkart, Michael DBioorganic & medicinal chemistry letters2010 Aug 154936-920620055
Microscopic imaging and spectroscopy with scattered light.Boustany, Nada N; Boppart, Stephen A; Backman, VadimAnnual review of biomedical engineering2010 Aug 15285-31420617940
Synthesis of substituted chromanones: an organocatalytic aldol/oxa-Michael reaction.Butler, Jeffrey D; Conrad, Wayne E; Lodewyk, Michael W; Fettinger, James C; Tantillo, Dean J; Kurth, Mark JOrganic letters2010 Aug 63410-320617821
Photoconversion of purified fluorescent proteins and dual-probe optical highlighting in live cells.Kremers, Gert-Jan; Piston, DavidJournal of visualized experiments : JoVE201020613710
Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology.Thorne, Natasha; Inglese, James; Auld, Douglas SChemistry & biology2010 Jun 25646-5720609414
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.Lackner, Laura L; Nunnari, JodiChemistry & biology2010 Jun 25578-8320609407
Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence.Salovich, James M; Lindsley, Craig W; Hopkins, Corey RTetrahedron letters2010 Jul 213796-379920606711
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.Judson, Richard S; Martin, Matthew T; Reif, David M; Houck, Keith A; Knudsen, Thomas B; Rotroff, Daniel M; Xia, Menghang; Sakamuru, Srilatha; Huang, Ruili; Shinn, Paul; Austin, Christopher P; Kavlock, Robert J; Dix, David JEnvironmental science & technology2010 Aug 15979-8520602530
A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist.Brahimi, Fouad; Liu, Jing; Malakhov, Andrey; Chowdhury, Shafinaz; Purisima, Enrico O; Ivanisevic, Ljubica; Caron, Antoine; Burgess, Kevin; Saragovi, H UriBiochimica et biophysica acta2010 Sep1018-2620600627
m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol.Hall, Michael A; Xi, Jin; Lor, Chong; Dai, Shuiping; Pearce, Robert; Dailey, William P; Eckenhoff, Roderic GJournal of medicinal chemistry2010 Aug 125667-7520597506
Peptide reporters of kinase activity in whole cell lysates.Wu, Ding; Sylvester, Juliesta E; Parker, Laurie L; Zhou, Guangchang; Kron, Stephen JBiopolymers2010475-8620593469
Towards interoperable and reproducible QSAR analyses: Exchange of datasets.Spjuth O, Willighagen EL, Guha R, Eklund M, Wikberg JE.J Cheminform2010 Jun 30520591161
High-throughput screening of chemical exchange saturation transfer MR contrast agents.Liu, Guanshu; Gilad, Assaf A; Bulte, Jeff W M; van Zijl, Peter C M; McMahon, Michael TContrast media & molecular imaging2010 May-Jun162-7020586030
Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions.Gao, Zhaobing; Zhang, Tangzhi; Wu, Meng; Xiong, Qiaojie; Sun, Haiyan; Zhang, Yinan; Zu, Liansuo; Wang, Wei; Li, MinThe Journal of biological chemistry2010 Sep 328322-3220584905
Protein kinase D as a potential new target for cancer therapy.LaValle, Courtney R; George, Kara M; Sharlow, Elizabeth R; Lazo, John S; Wipf, Peter; Wang, Q JaneBiochimica et biophysica acta2010 Dec183-9220580776
A Convenient Synthetic Route to Furan Esters and Lactones by Palladium-Catalyzed Carboalkoxylation or Cyclocarbonylation of Hydroxyl-Substituted 3-Iodofurans.Cho, Chul-Hee; Larock, Richard CTetrahedron letters2010 Jun 303417-342120577579
Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy.Rolfe, Alan; Hanson, Paul RTetrahedron letters2009 Dec 166935-693720577568
Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology.Charles, Richelle C; Sheikh, Alaullah; Krastins, Bryan; Harris, Jason B; Bhuiyan, M Saruar; LaRocque, Regina C; Logvinenko, Tanya; Sarracino, David A; Kudva, Indira T; Eisenstein, Jana; Podolsky, Michael J; Kalsy, Anuj; Brooks, W Abdullah; Ludwig, AlbrechClinical and vaccine immunology : CVI2010 Aug1188-9520573880
In silico binary classification QSAR models based on 4D-fingerprints and MOE descriptors for prediction of hERG blockage.Su, Bo-Han; Shen, Meng-yu; Esposito, Emilio Xavier; Hopfinger, Anton J; Tseng, Yufeng JJournal of chemical information and modeling2010 Jul 261304-1820565102
Intestinal ferroportin expression in pediatric Crohn's disease.Burpee, Tyler; Mitchell, Paul; Fishman, Douglas; Islam, Shabana; Nemeth, Elizabeta; Westerman, Mark; Wessling-Resnick, Marianne; Grand, Richard JInflammatory bowel diseases2011 Feb524-3120564534
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.Taldone, Tony; Gillan, Victoria; Sun, Weilin; Rodina, Anna; Patel, Pallav; Maitland, Kirsty; O'Neill, Kerry; Chiosis, Gabriela; Devaney, EileenPLoS neglected tropical diseases2010e71420559560
Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification.Cunningham, Christopher W; Mukhopadhyay, Archana; Lushington, Gerald H; Blagg, Brian S J; Prisinzano, Thomas E; Krise, Jeffrey PMolecular pharmaceutics2010 Aug 21301-1020557111
Tandem 6pi-electrocyclization and cycloaddition of nitrodienes to yield multicyclic nitroso acetals.Creech, Gardner S; Kwon, OhyunJournal of the American Chemical Society2010 Jul 78876-720557050
Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Chou, Danny Hung-Chieh; Bodycombe, Nicole E; Carrinski, Hyman A; Lewis, Timothy A; Clemons, Paul A; Schreiber, Stuart L; Wagner, Bridget KACS chemical biology2010 Aug 20729-3420550176
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.Blodgett, Joshua A V; Oh, Dong-Chan; Cao, Shugeng; Currie, Cameron R; Kolter, Roberto; Clardy, JonProceedings of the National Academy of Sciences of the United States of America2010 Jun 2911692-720547882
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.Engel, Juan C; Ang, Kenny K H; Chen, Steven; Arkin, Michelle R; McKerrow, James H; Doyle, Patricia SAntimicrobial agents and chemotherapy2010 Aug3326-3420547819
An economic framework to prioritize confirmatory tests after a high-throughput screen.Swamidass, S Joshua; Bittker, Joshua A; Bodycombe, Nicole E; Ryder, Sean P; Clemons, Paul AJournal of biomolecular screening2010 Jul680-620547534
Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.Kiselyuk, Alice; Farber-Katz, Suzette; Cohen, Tom; Lee, Seung-Hee; Geron, Ifat; Azimi, Behrad; Heynen-Genel, Susanne; Singer, Oded; Price, Jeffrey; Mercola, Mark; Itkin-Ansari, Pamela; Levine, FredJournal of biomolecular screening2010 Jul663-7020547533
Intermolecular C-O addition of carboxylic acids to arynes.Dubrovskiy, Anton V; Larock, Richard COrganic letters2010 Jul 163117-920545313
Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.Bhave, Gautam; Lonergan, Daniel; Chauder, Brian A; Denton, Jerod SFuture medicinal chemistry2010 May757-7420543968
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.Ferreira, Rafaela S; Simeonov, Anton; Jadhav, Ajit; Eidam, Oliv; Mott, Bryan T; Keiser, Michael J; McKerrow, James H; Maloney, David J; Irwin, John J; Shoichet, Brian KJournal of medicinal chemistry2010 Jul 84891-90520540517
Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists.Liu, Jing; Brahimi, Fouad; Saragovi, H Uri; Burgess, KevinJournal of medicinal chemistry2010 Jul 85044-820540510
PESDserv: a server for high-throughput comparison of protein binding site surfaces.Das, Sourav; Krein, Michael P; Breneman, Curt MBioinformatics (Oxford, England)2010 Aug 11913-420538727
Modulation of bitter taste perception by a small molecule hTAS2R antagonist.Slack, Jay P; Brockhoff, Anne; Batram, Claudia; Menzel, Susann; Sonnabend, Caroline; Born, Stephan; Galindo, Maria Mercedes; Kohl, Susann; Thalmann, Sophie; Ostopovici-Halip, Liliana; Simons, Christopher T; Ungureanu, Ioana; Duineveld, Kees; Bologa, CristCurrent biology : CB2010 Jun 221104-920537538
Synergistic allelochemicals from a freshwater cyanobacterium.Leao, Pedro N; Pereira, Alban R; Liu, Wei-Ting; Ng, Julio; Pevzner, Pavel A; Dorrestein, Pieter C; Konig, Gabriele M; Vasconcelos, Vitor M; Gerwick, William HProceedings of the National Academy of Sciences of the United States of America2010 Jun 2211183-820534563
Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas.Carpenter, Richard D; Natarajan, Arutselvan; Lau, Edmond Y; Andrei, Mirela; Solano, Danielle M; Lightstone, Felice C; Denardo, Sally J; Lam, Kit S; Kurth, Mark JCancer research2010 Jul 15448-5620530664
Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs.Mink, Sheldon R; Vashistha, Surabhi; Zhang, Wenxuan; Hodge, Amanda; Agus, David B; Jain, AnjaliMolecular cancer research : MCR2010 Jun809-2020530582
Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.Roman, David L; Blazer, Levi L; Monroy, C Aaron; Neubig, Richard RMolecular pharmacology2010 Sep360-520530129
Syntheses and biological evaluation of ring-C modified colchicine analogs.Yang, Baiyuan; Zhu, Zhiqing C; Goodson, Holly V; Miller, Marvin JBioorganic & medicinal chemistry letters2010 Jun 153831-320529690
Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.Liu, Zhang; Nefzi, AdelJournal of combinatorial chemistry2010 Jul 12566-7020527770
Absolute configuration of brevisamide and brevisin: confirmation of a universal biosynthetic process for Karenia brevis polyethers.Van Wagoner, Ryan M; Satake, Masayuki; Bourdelais, Andrea J; Baden, Daniel G; Wright, Jeffrey L CJournal of natural products2010 Jun 251177-920527743
Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens.Kontnik, Renee; Crawford, Jason M; Clardy, JonACS chemical biology2010 Jul 16659-6520524642
Synthesis of quinazolines from N-(2-nitrophenylsulfonyl)iminodiacetate and alpha-(2-nitrophenylsulfonyl)amino ketones via 2H-indazole 1-oxides.Krupkova, Sona; Slough, Greg A; Krchnak, ViktorThe Journal of organic chemistry2010 Jul 24562-620524619
Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division.Christen, Matthias; Kulasekara, Hemantha D; Christen, Beat; Kulasekara, Bridget R; Hoffman, Lucas R; Miller, Samuel IScience (New York, N.Y.)2010 Jun 41295-720522779
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Zmuda, Erik J; Qi, Ling; Zhu, Michael X; Mirmira, Raghavendra G; Montminy, Marc R; Hai, TsonwinMolecular endocrinology (Baltimore, Md.)2010 Jul1423-3320519332
Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes.Book, Adam J; Gladman, Nicholas P; Lee, Sang-Sook; Scalf, Mark; Smith, Lloyd M; Vierstra, Richard DThe Journal of biological chemistry2010 Aug 1325554-6920516081
A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A.Brunell, David; Weissbach, Herbert; Hodder, Peter; Brot, NathanAssay and drug development technologies2010 Oct615-2020515413
Structural Characterization of Methanol Substituted Lanthanum Halides.Boyle, Timothy J; Ottley, Leigh Anna M; Alam, Todd M; Rodriguez, Mark A; Yang, Pin; McIntyre, Sarah KPolyhedron2010 May 101784-179520514349
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity.Colton, Craig K; Kong, Qiongman; Lai, Liching; Zhu, Michael X; Seyb, Kathleen I; Cuny, Gregory D; Xian, Jun; Glicksman, Marcie A; Lin, Chien-Liang GlennJournal of biomolecular screening2010 Jul653-6220508255
A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.Huang, Gang; Zhang, Chunfu; Li, Shunzi; Khemtong, Chalermchai; Yang, Su-Geun; Tian, Ruhai; Minna, John D; Brown, Kathlynn C; Gao, JinmingJournal of materials chemistry20096367-637220505790
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.Leissring, Malcolm A; Malito, Enrico; Hedouin, Sabrine; Reinstatler, Lael; Sahara, Tomoko; Abdul-Hay, Samer O; Choudhry, Shakeel; Maharvi, Ghulam M; Fauq, Abdul H; Huzarska, Malwina; May, Philip S; Choi, Sungwoon; Logan, Todd P; Turk, Benjamin E; Cantley,PloS one2010e1050420498699
Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.Harmon, Dana E; Davis, Alison J; Castillo, Cynthia; Mecsas, JoanAntimicrobial agents and chemotherapy2010 Aug3241-5420498321
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane.Berndt, N; Yang, H; Trinczek, B; Betzi, S; Zhang, Z; Wu, B; Lawrence, N J; Pellecchia, M; Schonbrunn, E; Cheng, J Q; Sebti, S MCell death and differentiation2010 Nov1795-80420489726
Lymphatic biodistribution of polylactide nanoparticles.Chaney, Eric J; Tang, Li; Tong, Rong; Cheng, Jianjun; Boppart, Stephen AMolecular imaging2010 Jun153-6220487681
Advances in molecular imaging with ultrasound.Gessner, Ryan; Dayton, Paul AMolecular imaging2010 Jun117-2720487678
Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents.Nayak, Tapan K; Dennis, Megan K; Ramesh, Chinnasamy; Burai, Ritwik; Atcher, Robert W; Sklar, Larry A; Norenberg, Jeffrey P; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric RACS chemical biology2010 Jul 16681-9020486699
Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules.Peddibhotla, Satyamaheshwar; Shi, Ranxin; Khan, Pasha; Smith, Layton H; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Okolotowicz, Karl J; Cashman, John R; Reed, John C; Roth, Gregory PJournal of medicinal chemistry2010 Jun 244793-720481485
Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography.Ralston, Tyler S; Adie, Steven G; Marks, Daniel L; Boppart, Stephen A; Carney, P ScottOptics letters2010 May 151683-520479849
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.Wilson, David M; Keshari, Kayvan R; Larson, Peder E Z; Chen, Albert P; Hu, Simon; Van Criekinge, Mark; Bok, Robert; Nelson, Sarah J; Macdonald, Jeffrey M; Vigneron, Daniel B; Kurhanewicz, JohnJournal of magnetic resonance (San Diego, Calif. : 1997)2010 Jul141-720478721
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.Shah, Parag P; Wang, Tianhua; Kaletsky, Rachel L; Myers, Michael C; Purvis, Jeremy E; Jing, Huiyan; Huryn, Donna M; Greenbaum, Doron C; Smith 3rd, Amos B; Bates, Paul; Diamond, Scott LMolecular pharmacology2010 Aug319-2420466822
A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo.Shi, Q; Nguyen, A T; Angell, Y; Deng, D; Na, C-R; Burgess, K; Roberts, D D; Brunicardi, F C; Templeton, N SGene therapy2010 Sep1085-9720463761
A high-throughput screen for chemical inhibitors of exocytic transport in yeast.Zhang, Lisha; Nebane, N Miranda; Wennerberg, Krister; Li, Yujie; Neubauer, Valerie; Hobrath, Judith V; McKellip, Sara; Rasmussen, Lynn; Shindo, Nice; Sosa, Melinda; Maddry, Joseph A; Ananthan, Subramaniam; Piazza, Gary A; White, E Lucile; Harsay, EdinaChembiochem : a European journal of chemical biology2010 Jun 141291-30120461743
The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature.Li, Luowei; Shukla, Suneet; Lee, Andrew; Garfield, Susan H; Maloney, David J; Ambudkar, Suresh V; Yuspa, Stuart HCancer research2010 May 1120460505
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.Jiang, Jian-kang; Boxer, Matthew B; Vander Heiden, Matthew G; Shen, Min; Skoumbourdis, Amanda P; Southall, Noel; Veith, Henrike; Leister, William; Austin, Christopher P; Park, Hee Won; Inglese, James; Cantley, Lewis C; Auld, Douglas S; Thomas, Craig JBioorganic & medicinal chemistry letters2010 Jun 13387-9320451379
Mechanism-based crosslinking as a gauge for functional interaction of modular synthases.Worthington, Andrew S; Porter, Douglas F; Burkart, Michael DOrganic & biomolecular chemistry2010 Apr 211769-7220449476
Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.Zhou, Wei; Madrid, Peter; Fluitt, Amy; Stahl, Andreas; Xie, Xinmin SimonJournal of biomolecular screening2010 Jun488-9720448275
A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens.Moshiri, Houtan; Salavati, RezaNucleic acids research2010 Jule13820444864
Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.Wang, Jiangbo; Lu, Jiuyi; Bond, Michael C; Chen, Minyong; Ren, Xiu-Rong; Lyerly, H Kim; Barak, Larry S; Chen, WeiProceedings of the National Academy of Sciences of the United States of America2010 May 189323-820439738
Application of kernel functions for accurate similarity search in large chemical databases.Wang, Xiaohong; Huan, Jun; Smalter, Aaron; Lushington, Gerald HBMC bioinformatics2010S820438655
Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.Liu, Zhuqing; Myers, Michael C; Shah, Parag P; Beavers, Mary Pat; Benedetti, Phillip A; Diamond, Scott L; Smith 3rd, Amos B; Huryn, Donna MCombinatorial chemistry & high throughput screening2010 May337-5120438448
Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones.Donald, Michael B; Conrad, Wayne E; Oakdale, James S; Butler, Jeffrey D; Haddadin, Makhluf J; Kurth, Mark JOrganic letters2010 Jun 42524-720438102
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.Chang, Yanqi; Ganesh, Thota; Horton, John R; Spannhoff, Astrid; Liu, Jin; Sun, Aiming; Zhang, Xing; Bedford, Mark T; Shinkai, Yoichi; Snyder, James P; Cheng, XiaodongJournal of molecular biology2010 Jul 21-720434463
D-amino acids trigger biofilm disassembly.Kolodkin-Gal, Ilana; Romero, Diego; Cao, Shugeng; Clardy, Jon; Kolter, Roberto; Losick, RichardScience (New York, N.Y.)2010 Apr 30627-920431016
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.Uddin, Md Jashim; Crews, Brenda C; Blobaum, Anna L; Kingsley, Philip J; Gorden, D Lee; McIntyre, J Oliver; Matrisian, Lynn M; Subbaramaiah, Kotha; Dannenberg, Andrew J; Piston, David W; Marnett, Lawrence JCancer research2010 May 13618-2720430759
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.Talukdar, Arindam; Morgunova, Ekaterina; Duan, Jianxin; Meining, Winfried; Foloppe, Nicolas; Nilsson, Lennart; Bacher, Adelbert; Illarionov, Boris; Fischer, Markus; Ladenstein, Rudolf; Cushman, MarkBioorganic & medicinal chemistry2010 May 153518-3420430628
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.Kumar, Naresh; Solt, Laura A; Wang, Yongjun; Rogers, Pamela M; Bhattacharyya, Gargi; Kamenecka, Theodore M; Stayrook, Keith R; Crumbley, Christine; Floyd, Z Elizabeth; Gimble, Jeffrey M; Griffin, Patrick R; Burris, Thomas PEndocrinology2010 Jul3015-2520427485
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.Neumann, Susanne; Huang, Wenwei; Eliseeva, Elena; Titus, Steve; Thomas, Craig J; Gershengorn, Marvin CEndocrinology2010 Jul3454-920427476
Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues.Li, Yangmei; Giulionatti, Marc; Houghten, Richard AOrganic letters2010 May 212250-320426464
Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.Passer, Brent J; Cheema, Tooba; Zhou, Bingsen; Wakimoto, Hiroaki; Zaupa, Cecile; Razmjoo, Mani; Sarte, Jason; Wu, Shulin; Wu, Chin-lee; Noah, James W; Li, Qianjun; Buolamwini, John K; Yen, Yun; Rabkin, Samuel D; Martuza, Robert LCancer research2010 May 153890-520424118
A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells.Sylvester, Juliesta E; Kron, Stephen JMolecular cancer therapeutics2010 May1469-8120423990
Hydrophobic pharmaceuticals mediated self-assembly of beta-cyclodextrin containing hydrophilic copolymers: novel chemical responsive nano-vehicles for drug delivery.Zhang, Jianxiang; Ellsworth, Kristin; Ma, Peter XJournal of controlled release : official journal of the Controlled Release Society2010 Jul 14116-2320417674
Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.Li, Ning; Thompson, Scott; Schultz, David C; Zhu, Weiliang; Jiang, Hualiang; Luo, Cheng; Lieberman, Paul MPloS one2010e1012620405039
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.Sharlow, Elizabeth R; Lyda, Todd A; Dodson, Heidi C; Mustata, Gabriela; Morris, Meredith T; Leimgruber, Stephanie S; Lee, Kuo-Hsiung; Kashiwada, Yoshiki; Close, David; Lazo, John S; Morris, James CPLoS neglected tropical diseases2010e65920405000
In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes.John, Renu; Rezaeipoor, Robabeh; Adie, Steven G; Chaney, Eric J; Oldenburg, Amy L; Marjanovic, Marina; Haldar, Justin P; Sutton, Bradley P; Boppart, Stephen AProceedings of the National Academy of Sciences of the United States of America2010 May 48085-9020404194
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.Burai, Ritwik; Ramesh, Chinnasamy; Shorty, Marvin; Curpan, Ramona; Bologa, Cristian; Sklar, Larry A; Oprea, Tudor; Prossnitz, Eric R; Arterburn, Jeffrey BOrganic & biomolecular chemistry2010 May 72252-920401403
Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.Rolfe, Alan; Lushington, Gerald H; Hanson, Paul ROrganic & biomolecular chemistry2010 May 72198-20320401396
Intracellular imaging of organelles with new water-soluble benzophenoxazine dyes.Jose, Jiney; Loudet, Aurore; Ueno, Yuichiro; Barhoumi, Rola; Burghardt, Robert C; Burgess, KevinOrganic & biomolecular chemistry2010 May 72052-920401381
Synthesis of 2H-indazoles by the [3 + 2] cycloaddition of arynes and sydnones.Wu, Chunrui; Fang, Yuesi; Larock, Richard C; Shi, FengOrganic letters2010 May 212234-720394430
A formal [4 + 4] complementary ambiphile pairing reaction: a new cyclization pathway for ortho-quinone methides.Samarakoon, Thiwanka B; Hur, Moon Y; Kurtz, Ryan D; Hanson, Paul ROrganic letters2010 May 212182-520394415
A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I; Rauh, Daniel; Kaiser, Markus; Waldmann, HerbertAngewandte Chemie (International ed. in English)2010 May 103666-7020394088
High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish.Shin, Jordan T; Pomerantsev, Eugene V; Mably, John D; MacRae, Calum APhysiological genomics2010 Jul 7300-920388839
Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.Zhou, Cong-Ying; Li, Jing; Peddibhotla, Satyamaheshwar; Romo, DanielOrganic letters2010 May 72104-720387852
Design, synthesis, and diversification of 5,5-dimethyl cyclohexen-1,4-dione library.Tanifum, Eric A; Gilbertson, Scott RJournal of combinatorial chemistry2010 May 10318-2020387791
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.Kwiatkowski, Nicholas; Jelluma, Nannette; Filippakopoulos, Panagis; Soundararajan, Meera; Manak, Michael S; Kwon, Mijung; Choi, Hwan Geun; Sim, Taebo; Deveraux, Quinn L; Rottmann, Sabine; Pellman, David; Shah, Jagesh V; Kops, Geert J P L; Knapp, Stefan; GNature chemical biology2010 May359-6820383151
Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile.Li, Xiaohai; Kamenecka, Theodore M; Cameron, Michael DDrug metabolism and disposition: the biological fate of chemicals2010 Jul1238-4520382753
Proton-Resistant Quantum Dots: Stability in Gastrointestinal Fluids and Implications for Oral Delivery of Nanoparticle Agents.Mohs, Aaron M; Duan, Hongwei; Kairdolf, Brad A; Smith, Andrew M; Nie, ShumingNano research2009 Jun 1500-50820379372
Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.Ye, Long; Knapp, John M; Sangwung, Panjamaporn; Fettinger, James C; Verkman, A S; Kurth, Mark JJournal of medicinal chemistry2010 May 133772-8120373765
Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.Chlipala, George E; Pham, Huu Tri; Nguyen, Van Hung; Krunic, Aleksej; Shim, Sang Hee; Soejarto, D Doel; Orjala, JimmyJournal of natural products2010 Apr 23784-720373744
Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment.Zou, Wei; Roth, Robert A; Younis, Husam S; Burgoon, Lyle D; Ganey, Patricia EToxicology2010 Jun 432-820371263
Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays.Buranda, Tione; Wu, Yang; Perez, Dominique; Jett, Stephen D; BonduHawkins, Virginie; Ye, Chunyan; Edwards, Bruce; Hall, Pamela; Larson, Richard S; Lopez, Gabriel P; Sklar, Larry A; Hjelle, BrianAnalytical biochemistry2010 Jul 15151-6020363206
Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design.Ziebart, Kristin T; Dixon, Seth M; Avila, Belem; El-Badri, Mohamed H; Guggenheim, Kathryn G; Kurth, Mark J; Toney, Michael DJournal of medicinal chemistry2010 May 133718-2920359225
The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.Bauer, Renato A; DiBlasi, Christine M; Tan, Derek SOrganic letters2010 May 72084-720356070
Mining connections between chemicals, proteins, and diseases extracted from Medline annotations.Baker, Nancy C; Hemminger, Bradley MJournal of biomedical informatics2010 Aug510-920348023
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Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.Shi, Ranxin; Re, Daniel; Dudl, Eric; Cuddy, Michael; Okolotowicz, Karl J; Dahl, Russell; Su, Ying; Hurder, Andrew; Kitada, Shinichi; Peddibhotla, Satyamaheshwar; Roth, Gregory P; Smith, Layton H; Kipps, Thomas J; Cosford, Nicholas; Cashman, John; Reed, JoACS chemical biology2010 Mar 19287-9920141195
Bright, Red Single-Molecule Emitters: Synthesis and Properties of Environmentally Sensitive Dicyanomethylenedihydrofuran (DCDHF) Fluorophores with Bisaromatic Conjugation.Lu, Zhikuan; Liu, Na; Lord, Samuel J; Bunge, Scott D; Moerner, W E; Twieg, Robert JChemistry of materials : a publication of the American Chemical Society2009 Feb 5797-81020140061
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Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography.Oldenburg, Amy L; Boppart, Stephen APhysics in medicine and biology2010 Feb 211189-20120124653
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Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism.Keshari, Kayvan R; Kurhanewicz, John; Jeffries, Rex E; Wilson, David M; Dewar, Brian J; Van Criekinge, Mark; Zierhut, Matthew; Vigneron, Daniel B; Macdonald, Jeffrey MMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2010 Feb322-920099325
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Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.Seyedsayamdost, Mohammad R; Chandler, Josephine R; Blodgett, Joshua A V; Lima, Patricia S; Duerkop, Breck A; Oinuma, Ken-Ichi; Greenberg, E Peter; Clardy, JonOrganic letters2010 Feb 19716-920095633
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Rad54, the motor of homologous recombination.Mazin, Alexander V; Mazina, Olga M; Bugreev, Dmitry V; Rossi, Matthew JDNA repair2010 Mar 2286-30220089461
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.Ariazi, Eric A; Brailoiu, Eugen; Yerrum, Smitha; Shupp, Heather A; Slifker, Michael J; Cunliffe, Heather E; Black, Michael A; Donato, Anne L; Arterburn, Jeffrey B; Oprea, Tudor I; Prossnitz, Eric R; Dun, Nae J; Jordan, V CraigCancer research2010 Feb 11184-9420086172
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Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis.Bargagna-Mohan, Paola; Paranthan, Riya R; Hamza, Adel; Dimova, Neviana; Trucchi, Beatrice; Srinivasan, Cidambi; Elliott, Gregory I; Zhan, Chang-Guo; Lau, Daniel L; Zhu, Haiyan; Kasahara, Kousuke; Inagaki, Masaki; Cambi, Franca; Mohan, RoyceThe Journal of biological chemistry2010 Mar 57657-6920048155
A simple and mild synthesis of 1H-isochromenes and (Z)-1-alkylidene-1,3-dihydroisobenzofurans by the iodocyclization of 2-(1-alkynyl)benzylic alcohols.Mancuso, Raffaella; Mehta, Saurabh; Gabriele, Bartolo; Salerno, Giuseppe; Jenks, William S; Larock, Richard CThe Journal of organic chemistry2010 Feb 5897-90120043652
Real-time partitioning of octadecyl rhodamine B into bead-supported lipid bilayer membranes revealing quantitative differences in saturable binding sites in DOPC and 1:1:1 DOPC/SM/cholesterol membranes.Buranda, Tione; Wu, Yang; Perez, Dominique; Chigaev, Alexandre; Sklar, Larry AThe journal of physical chemistry. B2010 Jan 281336-4920043651
Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression.Blasiak, Leah C; Clardy, JonJournal of the American Chemical Society2010 Jan 27926-720041686
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Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.Herath, Ananda; Dahl, Russell; Cosford, Nicholas D POrganic letters2010 Feb 5412-520038130
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.Hou, Shangwei; Vigeland, Leif E; Zhang, Guangping; Xu, Rong; Li, Min; Heinemann, Stefan H; Hoshi, ToshinoriThe Journal of biological chemistry2010 Feb 266434-4220037152
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A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.Kota, Smitha; Scampavia, Louis; Spicer, Timothy; Beeler, Aaron B; Takahashi, Virginia; Snyder, John K; Porco, John A; Hodder, Peter; Strosberg, Arthur DonnyAssay and drug development technologies2010 Feb96-10520035614
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Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry.Yan, Shanshan; Miller, Marvin J; Wencewicz, Timothy A; Mollmann, UteBioorganic & medicinal chemistry letters2010 Feb 11302-520031407
Uniting anion relay chemistry with Pd-mediated cross coupling: design, synthesis and evaluation of bifunctional aryl and vinyl silane linchpins.Smith 3rd, Amos B; Kim, Won-Suk; Tong, RongbiaoOrganic letters2010 Feb 5588-9120028107
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.Niswender, Colleen M; Johnson, Kari A; Miller, Nicole R; Ayala, Jennifer E; Luo, Qingwei; Williams, Richard; Saleh, Samir; Orton, Darren; Weaver, C David; Conn, P JeffreyMolecular pharmacology2010 Mar459-6820026717
The ferritin superfamily: Supramolecular templates for materials synthesis.Uchida, Masaki; Kang, Sebyung; Reichhardt, Courtney; Harlen, Kevin; Douglas, TrevorBiochimica et biophysica acta2010 Aug834-4520026386
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Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.Kelly, Kimberly A; Shaw, Stanley Y; Nahrendorf, Matthias; Kristoff, Kelly; Aikawa, Elena; Schreiber, Stuart L; Clemons, Paul A; Weissleder, RalphIntegrative biology : quantitative biosciences from nano to macro2009 Apr311-720023731
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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.Boxer, Matthew B; Jiang, Jian-kang; Vander Heiden, Matthew G; Shen, Min; Skoumbourdis, Amanda P; Southall, Noel; Veith, Henrike; Leister, William; Austin, Christopher P; Park, Hee Won; Inglese, James; Cantley, Lewis C; Auld, Douglas S; Thomas, Craig JJournal of medicinal chemistry2010 Feb 111048-5520017496
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Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.Tinsley, Heather N; Gary, Bernard D; Keeton, Adam B; Zhang, Wei; Abadi, Ashraf H; Reynolds, Robert C; Piazza, Gary AMolecular cancer therapeutics2009 Dec3331-4019996273
Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).Sivendran, Sharmila; Jones, Victoria; Sun, Dianqing; Wang, Yi; Grzegorzewicz, Anna E; Scherman, Michael S; Napper, Andrew D; McCammon, J Andrew; Lee, Richard E; Diamond, Scott L; McNeil, MichaelBioorganic & medicinal chemistry2010 Jan 15896-90819969466
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.Wang, Yongjun; Kumar, Naresh; Solt, Laura A; Richardson, Timothy I; Helvering, Leah M; Crumbley, Christine; Garcia-Ordonez, Ruben D; Stayrook, Keith R; Zhang, Xi; Novick, Scott; Chalmers, Michael J; Griffin, Patrick R; Burris, Thomas PThe Journal of biological chemistry2010 Feb 125013-2519965867
Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles.Khemtong, Chalermchai; Kessinger, Chase W; Togao, Osamu; Ren, Jimin; Takahashi, Masaya; Sherry, A Dean; Gao, JinmingConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20094095-719964823
Automated classification of renal cell carcinoma subtypes using scale invariant feature transform.Raza, S; Sharma, Yachna; Chaudry, Qaiser; Young, Andrew N; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20096687-9019964707
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Quality control of highly multiplexed proteomic immunostaining with quantum dots: correcting for crosstalk.Moffitt, Richard A; Caldwell, Matthew L; Liu, Tao; Liu, Jian; Nie, Shuming; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20096739-4219963937
Deblurring molecular images using desorption electrospray ionization mass spectrometry.Parry, R; Galhena, Asiri S; Fernandez, Facundo M; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20096731-419963935
Biomedical nanotechnology for molecular imaging, diagnostics, and targeted therapy.Nie, ShumingConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20094578-919963842
Solid-phase synthesis and chemical properties of 2-(2-amino/hydroxyethyl)-1-aryl-3,4-dihydropyrazino[1, 2-b]indazol-2-iums.Koci, Jan; Krchnak, ViktorJournal of combinatorial chemistry2010 Jan-Feb168-7519961214
Cyclopenta[b]pyrroles from triazines: synthetic and mechanistic studies.Ye, Long; Haddadin, Makhluf J; Lodewyk, Michael W; Ferreira, Andrew J; Fettinger, James C; Tantillo, Dean J; Kurth, Mark JOrganic letters2010 Jan 1164-719961148
Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR.Mills, Aaron D; Yoo, Choong; Butler, Jeffrey D; Yang, Baoxue; Verkman, A S; Kurth, Mark JBioorganic & medicinal chemistry letters2010 Jan 187-9119954980
Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity.Maddox, Jane F; Amuzie, Chidozie J; Li, Maoxiang; Newport, Sandra W; Sparkenbaugh, Erica; Cuff, Christopher F; Pestka, James J; Cantor, Glenn H; Roth, Robert A; Ganey, Patricia EJournal of toxicology and environmental health. Part A201058-7319953420
Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins.Jones, Adam C; Gerwick, Lena; Gonzalez, David; Dorrestein, Pieter C; Gerwick, William HBMC microbiology200924719951434
Nanostructured Biomaterials for Regeneration.Wei, Guobao; Ma, Peter XAdvanced functional materials2008 Nov 243566-358219946357
Imaging mass spectrometry of natural products.Esquenazi, Eduardo; Yang, Yu-Liang; Watrous, Jeramie; Gerwick, William H; Dorrestein, Pieter CNatural product reports2009 Dec1521-3419936384
Rapid comparison of protein binding site surfaces with property encoded shape distributions.Das, Sourav; Kokardekar, Arshad; Breneman, Curt MJournal of chemical information and modeling2009 Dec2863-7219919089
Translating metabolic exchange with imaging mass spectrometry.Yang, Yu-Liang; Xu, Yuquan; Straight, Paul; Dorrestein, Pieter CNature chemical biology2009 Dec885-719915536
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors.Ostrovsky, Olga; Eletto, Davide; Makarewich, Catherine; Barton, Elisabeth R; Argon, YairBiochimica et biophysica acta2010 Feb333-4119914304
Morphological and Phase Controlled Tungsten Based Nanoparticles: Synthesis and Characterization of Scheelites, Wolframites, and Oxides Nanomaterials.Hernandez-Sanchez, Bernadette A; Boyle, Timothy J; Pratt, Harry D; Rodriguez, Mark A; Brewer, Luke N; Dunphy, Darren RChemistry of materials : a publication of the American Chemical Society2008 Nov 116643-665619911034
Ultraviolet-visible non-supercontinuum ultrafast source enabled by switching single silicon strand-like photonic crystal fibers.Tu, Haohua; Boppart, Stephen AOptics express2009 Sep 2817983-819907587
A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.Gao, Wei; Hillwig, Matthew L; Huang, Luqi; Cui, Guanghong; Wang, Xueyong; Kong, Jianqiang; Yang, Bin; Peters, Reuben JOrganic letters2009 Nov 195170-319905026
Organotrifluoroborates and monocoordinated palladium complexes as catalysts--a perfect combination for Suzuki-Miyaura coupling.Molander, Gary A; Canturk, BelginAngewandte Chemie (International ed. in English)20099240-6119899086
Bioimaging: second window for in vivo imaging.Smith, Andrew M; Mancini, Michael C; Nie, ShumingNature nanotechnology2009 Nov710-119898521
A chemical genetic screen for modulators of exocytic transport identifies inhibitors of a transport mechanism linked to GTR2 function.Zhang, Lisha; Huang, Min; Harsay, EdinaEukaryotic cell2010 Jan116-2619897736
A role for the MS analysis of nucleic acids in the post-genomics age.Fabris, DanieleJournal of the American Society for Mass Spectrometry2010 Jan1-1319897384
New small molecule inhibitors of hepatitis C virus.Wei, Wanguo; Cai, Cuifang; Kota, Smitha; Takahashi, Virginia; Ni, Feng; Strosberg, A Donny; Snyder, John KBioorganic & medicinal chemistry letters2009 Dec 156926-3019896376
Phosphopantetheinyl transferase inhibition and secondary metabolism.Foley, Timothy L; Young, Brian S; Burkart, Michael DThe FEBS journal2009 Dec7134-4519895578
Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions.Li, Yangmei; Yongye, Austin; Giulianotti, Marc; Martinez-Mayorga, Karina; Yu, Yongping; Houghten, Richard AJournal of combinatorial chemistry2009 Nov-Dec1066-7219894764
An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.Mo, Shunyan; Krunic, Aleksej; Pegan, Scott D; Franzblau, Scott G; Orjala, JimmyJournal of natural products2009 Nov2043-519888742
Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties.Liepold, Lars O; Abedin, Md Joynal; Buckhouse, Emily D; Frank, Joseph A; Young, Mark J; Douglas, TrevorNano letters2009 Dec4520-619888720
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.Hu, Hongzhen; Tian, Jinbin; Zhu, Yingmin; Wang, Chunbo; Xiao, Rui; Herz, Jeffrey M; Wood, Jackie D; Zhu, Michael XPflugers Archiv : European journal of physiology2010 Mar579-9219888597
Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.Sharlow, Elizabeth R; Close, David; Shun, Tongying; Leimgruber, Stephanie; Reed, Robyn; Mustata, Gabriela; Wipf, Peter; Johnson, Jacob; O'Neil, Michael; Grogl, Max; Magill, Alan J; Lazo, John SPLoS neglected tropical diseases2009e54019888337
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.Kumar, Naresh; Solt, Laura A; Conkright, Juliana J; Wang, Yongjun; Istrate, Monica A; Busby, Scott A; Garcia-Ordonez, Ruben D; Burris, Thomas P; Griffin, Patrick RMolecular pharmacology2010 Feb228-3619887649
Determinism and divergence of apoptosis susceptibility in mammalian cells.Bhola, Patrick D; Simon, Sanford MJournal of cell science2009 Dec 14296-30219887588
From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.Pagano, Nicholas; Wong, Eric Y; Breiding, Tom; Liu, Haidong; Wilbuer, Alexander; Bregman, Howard; Shen, Qi; Diamond, Scott L; Meggers, EricThe Journal of organic chemistry2009 Dec 48997-900919886617
Identification of a functional network of human epigenetic silencing factors.Poleshko, Andrey; Einarson, Margret B; Shalginskikh, Natalia; Zhang, Rugang; Adams, Peter D; Skalka, Anna Marie; Katz, Richard AThe Journal of biological chemistry2010 Jan 1422-3319880521
Identification of novel agonists of the integrin CD11b/CD18.Faridi, Mohd Hafeez; Maiguel, Dony; Barth, Constantinos J; Stoub, Darren; Day, Ruth; Schurer, Stephan; Gupta, VineetBioorganic & medicinal chemistry letters2009 Dec 156902-619879752
Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics.Easley, Christopher J; Rocheleau, Jonathan V; Head, W Steven; Piston, David WAnalytical chemistry2009 Nov 19086-9519874061
The drug transporter-metabolism alliance: uncovering and defining the interplay.Benet, Leslie ZMolecular pharmaceutics2009 Nov-Dec1631-4319874004
TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization.Samuelson, Lynn E; Dukes, Madeline J; Hunt, Colette R; Casey, Jonathan D; Bornhop, Darryl JBioconjugate chemistry2009 Nov2082-919863077
Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.Keshari, Kayvan R; Wilson, David M; Chen, Albert P; Bok, Robert; Larson, Peder E Z; Hu, Simon; Van Criekinge, Mark; Macdonald, Jeffrey M; Vigneron, Daniel B; Kurhanewicz, JohnJournal of the American Chemical Society2009 Dec 917591-619860409
Galactose toxicity in animals.Lai, Kent; Elsas, Louis J; Wierenga, Klaas JIUBMB life2009 Nov1063-7419859980
Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.Qureshi, Amir H; Chaoji, Vineet; Maiguel, Dony; Faridi, Mohd Hafeez; Barth, Constantinos J; Salem, Saeed M; Singhal, Mudita; Stoub, Darren; Krastins, Bryan; Ogihara, Mitsunori; Zaki, Mohammed J; Gupta, VineetPloS one2009e762719859549
Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.Sun, Aiming; Lu, Yang J; Hu, Haipeng; Shoji, Mamoru; Liotta, Dennis C; Snyder, James PBioorganic & medicinal chemistry letters2009 Dec 16627-3119854644
Identification of a new region of SARS-CoV S protein critical for viral entry.Guo, Ying; Tisoncik, Jennifer; McReynolds, Susanna; Farzan, Michael; Prabhakar, Bellur S; Gallagher, Thomas; Rong, Lijun; Caffrey, MichaelJournal of molecular biology2009 Dec 11600-519853613
Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure.Zhu, Hao; Martin, Todd M; Ye, Lin; Sedykh, Alexander; Young, Douglas M; Tropsha, AlexanderChemical research in toxicology2009 Dec1913-2119845371
Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis.Bhola, Patrick D; Mattheyses, Alexa L; Simon, Sanford MBiophysical journal2009 Oct 212222-3119843454
Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.Brothers, Shaun P; Saldanha, S Adrian; Spicer, Timothy P; Cameron, Michael; Mercer, Becky A; Chase, Peter; McDonald, Patricia; Wahlestedt, Claes; Hodder, Peter SMolecular pharmacology2010 Jan46-5719837904
Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm.Reifenberger, Jeff G; Toprak, Erdal; Kim, Hyeongjun; Safer, Dan; Sweeney, H Lee; Selvin, Paul RProceedings of the National Academy of Sciences of the United States of America2009 Oct 2718255-6019828438
Semiconductor nanocrystals: structure, properties, and band gap engineering.Smith, Andrew M; Nie, ShumingAccounts of chemical research2010 Feb 16190-20019827808
Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.Mumenthaler, Shannon M; Ng, Patricia Y B; Hodge, Amanda; Bearss, David; Berk, Gregory; Kanekal, Sarath; Redkar, Sanjeev; Taverna, Pietro; Agus, David B; Jain, AnjaliMolecular cancer therapeutics2009 Oct2882-9319825806
Biomechanical properties of in vivo human skin from dynamic optical coherence elastography.Liang, Xing; Boppart, Stephen AIEEE transactions on bio-medical engineering2010 Apr953-919822464
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).Dahl, Russell; Sergienko, Eduard A; Su, Ying; Mostofi, Yalda S; Yang, Li; Simao, Ana Maria; Narisawa, Sonoko; Brown, Brock; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Smith, Layton H; O'Neill, W Charles; Millan, Jose Luis; Cosford, Nicholas D PJournal of medicinal chemistry2009 Nov 126919-2519821572
A single molecule view of gene expression.Larson, Daniel R; Singer, Robert H; Zenklusen, DanielTrends in cell biology2009 Nov630-719819144
Partial internal reflections on total internal reflection fluorescent microscopy.Simon, Sanford MTrends in cell biology2009 Nov661-819818624
Solution-phase synthesis of a diverse isocoumarin library.Roy, Sujata; Roy, Sudipta; Neuenswander, Benjamin; Hill, David; Larock, Richard CJournal of combinatorial chemistry2009 Nov-Dec1128-3519817453
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.Gross, Stefan Alfred; Guzman, Gustavo Adolfo; Wissenbach, Ulrich; Philipp, Stephan Ernst; Zhu, Michael Xi; Bruns, Dieter; Cavalie, AdolfoThe Journal of biological chemistry2009 Dec 434423-3219815560
Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides.Matthew, Susan; Paul, Valerie J; Luesch, HendrikPhytochemistry2009 Dec2058-6319815244
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.Vidovic, Dusica; Schurer, Stephan CJournal of medicinal chemistry2009 Nov 126649-5919810703
Cancer and virus leads by HTS, chemical design and SEA data mining.Thepchatri, Pahk; Min, Jaeki; Ganesh, Thota; Du, Yuhong; Lewis, Iestyn; Kurtkaya, Serdar; Prussia, Andrew; Li, Lian; Sneed, Blossom; Plemper, Richard K; Fu, Haian; Liotta, Dennis C; Snyder, James P; Dingledine, Raymond; Sun, AimingCurrent topics in medicinal chemistry20091159-7119807668
The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L.Huryn, Donna M; Smith 3rd, Amos BCurrent topics in medicinal chemistry20091206-1619807666
A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).Wipf, Peter; Arnold, David; Carter, Karen; Dong, Shuzhi; Johnston, Paul A; Sharlow, Elizabeth; Lazo, John S; Huryn, DonnaCurrent topics in medicinal chemistry20091194-20519807663
Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30.Arterburn, Jeffrey B; Oprea, Tudor I; Prossnitz, Eric R; Edwards, Bruce S; Sklar, Larry ACurrent topics in medicinal chemistry20091227-3619807662
A model-based ensembling approach for developing QSARs.Zhang, Qianyi; Hughes-Oliver, Jacqueline M; Ng, Raymond TJournal of chemical information and modeling2009 Aug1857-6519807194
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.Emert-Sedlak, Lori; Kodama, Toshiaki; Lerner, Edwina C; Dai, Weixiang; Foster, Caleb; Day, Billy W; Lazo, John S; Smithgall, Thomas EACS chemical biology2009 Nov 20939-4719807124
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.Hollenhorst, Marie A; Clardy, Jon; Walsh, Christopher TBiochemistry2009 Nov 310467-7219807062
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.Deng, Xiaomin; Luyendyk, James P; Ganey, Patricia E; Roth, Robert APharmacological reviews2009 Sep262-8219805476
KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer.Gumireddy, Kiranmai; Li, Anping; Gimotty, Phyllis A; Klein-Szanto, Andres J; Showe, Louise C; Katsaros, Dionyssios; Coukos, George; Zhang, Lin; Huang, QihongNature cell biology2009 Nov1297-30419801974
3D pharmacophore mapping using 4D QSAR analysis for the cytotoxicity of lamellarins against human hormone-dependent T47D breast cancer cells.Thipnate, Poonsiri; Liu, Jianzhong; Hannongbua, Supa; Hopfinger, A JJournal of chemical information and modeling2009 Oct2312-2219799437
Acoustomotive optical coherence elastography for measuring material mechanical properties.Liang, Xing; Orescanin, Marko; Toohey, Kathleen S; Insana, Michael F; Boppart, Stephen AOptics letters2009 Oct 12894-619794759
An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis.Meier, Jordan L; Niessen, Sherry; Hoover, Heather S; Foley, Timothy L; Cravatt, Benjamin F; Burkart, Michael DACS chemical biology2009 Nov 20948-5719785476
Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.Guo, Songpo; Tipparaju, Suresh K; Pegan, Scott D; Wan, Baojie; Mo, Shunyan; Orjala, Jimmy; Mesecar, Andrew D; Franzblau, Scott G; Kozikowski, Alan PBioorganic & medicinal chemistry2009 Oct 157126-3019783449
Antituberculosis activity of the molecular libraries screening center network library.Maddry, Joseph A; Ananthan, Subramaniam; Goldman, Robert C; Hobrath, Judith V; Kwong, Cecil D; Maddox, Clinton; Rasmussen, Lynn; Reynolds, Robert C; Secrist 3rd, John A; Sosa, Melinda I; White, E Lucile; Zhang, WeiTuberculosis (Edinburgh, Scotland)2009 Sep354-6319783214
The nanofibrous architecture of poly(L-lactic acid)-based functional copolymers.Liu, Xiaohua; Ma, Peter XBiomaterials2010 Jan259-6919783035
Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate.Levin, Yakir S; Albers, Mark J; Butler, Thomas N; Spielman, Daniel; Peehl, Donna M; Kurhanewicz, JohnMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2009 Nov1091-819780158
Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.Pratt, Matthew R; Sekedat, Matthew D; Chiang, Kyle P; Muir, Tom WChemistry & biology2009 Sep 251001-1219778728
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering.Morrone, Dana; Lowry, Luke; Determan, Mara K; Hershey, David M; Xu, Meimei; Peters, Reuben JApplied microbiology and biotechnology2010 Feb1893-90619777230
A high-throughput approach for identification of novel general anesthetics.Lea, Wendy A; Xi, Jin; Jadhav, Ajit; Lu, Louis; Austin, Christopher P; Simeonov, Anton; Eckenhoff, Roderic GPloS one2009e715019777064
Alpha shapes applied to molecular shape characterization exhibit novel properties compared to established shape descriptors.Wilson, J Anthony; Bender, Andreas; Kaya, Taner; Clemons, Paul AJournal of chemical information and modeling2009 Oct2231-4119775113
Inducible Bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses.Wiley, James A; Richert, Laura E; Swain, Steve D; Harmsen, Ann; Barnard, Dale L; Randall, Troy D; Jutila, Mark; Douglas, Trevor; Broomell, Chris; Young, Mark; Harmsen, AllenPloS one2009e714219774076
Plasmonics enhancement of a luminescent or Raman-active layer in a multilayered metallic nanoshell.Norton, Stephen J; Vo-Dinh, TuanApplied optics2009 Sep 205040-919767916
Isoform-selective chemical inhibition of mDia-mediated actin assembly.Gauvin, Timothy J; Fukui, Jami; Peterson, Jeffrey R; Higgs, Henry NBiochemistry2009 Oct 139327-919764708
D-amino acids govern stationary phase cell wall remodeling in bacteria.Lam, Hubert; Oh, Dong-Chan; Cava, Felipe; Takacs, Constantin N; Clardy, Jon; de Pedro, Miguel A; Waldor, Matthew KScience (New York, N.Y.)2009 Sep 181552-519762646
Exploration of chromatic aberration for multiplanar imaging: proof of concept with implications for fast, efficient autofocus.Weinigel, Martin; Kellner, Albert L; Price, Jeffrey HCytometry. Part A : the journal of the International Society for Analytical Cytology2009 Dec999-100619760744
Modifications of DCDHF single molecule fluorophores to impart water solubility.Wang, Hui; Lu, Zhikuan; Lord, Samuel J; Moerner, W E; Twieg, Robert JTetrahedron letters2007 May 73471-347419759848
Conformational mAb as a tool for integrin ligand discovery.Njus, Ben H; Chigaev, Alexandre; Waller, Anna; Wlodek, Danuta; Ostopovici-Halip, Liliana; Ursu, Oleg; Wang, Wei; Oprea, Tudor I; Bologa, Cristian G; Sklar, Larry AAssay and drug development technologies2009 Oct507-1519754304
Clinical feasibility of microscopically-guided breast needle biopsy using a fiber-optic probe with computer-aided detection.Zysk, Adam M; Nguyen, Freddy T; Chaney, Eric J; Kotynek, Jan G; Oliphant, Uretz J; Bellafiore, Frank J; Johnson, Patricia A; Rowland, Kendrith M; Boppart, Stephen ATechnology in cancer research & treatment2009 Oct315-2119754207
Regio- and Stereoselective Indium Triflate-Mediated Nucleophilic Ring-Opening Reactions of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene and -[2.2.2]oct-5-ene Systems.Yang, Baiyuan; Miller, Marvin JThe Journal of organic chemistry2009 Sep 1519754105
Highly substituted indole library synthesis by palladium-catalyzed coupling reactions in solution and on a solid support.Worlikar, Shilpa A; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard CJournal of combinatorial chemistry2009 Sep-Oct875-919746991
Effective-substrate theory for optical reflection from a layered substrate.Landry, J P; Wang, X; Fei, Y Y; Zhu, X DJournal of the Optical Society of America. B, Optical physics2008 Jan 12021-202819746189
Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium.Charles, Richelle C; Harris, Jason B; Chase, Michael R; Lebrun, Lauren M; Sheikh, Alaullah; LaRocque, Regina C; Logvinenko, Tanya; Rollins, Sean M; Tarique, Abdullah; Hohmann, Elizabeth L; Rosenberg, Ian; Krastins, Bryan; Sarracino, David A; Qadri, FirdauPloS one2009e699419746165
Efficient hydrolysis of organotrifluoroborates via silica gel and water.Molander, Gary A; Cavalcanti, Livia N; Canturk, Belgin; Pan, Po-Shen; Kennedy, Lauren EThe Journal of organic chemistry2009 Oct 27364-919743828
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.Dai, Susie Y; Burris, Thomas P; Dodge, Jeffrey A; Montrose-Rafizadeh, Chahrzad; Wang, Yong; Pascal, Bruce D; Chalmers, Michael J; Griffin, Patrick RBiochemistry2009 Oct 139668-7619739677
Preparation of potassium azidoaryltrifluoroborates and their cross-coupling with aryl halides.Cho, Young Ae; Kim, Dong-Su; Ahn, Hong Ryul; Canturk, Belgin; Molander, Gary A; Ham, JungyeobOrganic letters2009 Oct 14330-319736957
Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals.Chen, Dianjun; Brahimi, Fouad; Angell, Yu; Li, Yu-Chin; Moscowicz, Jennifer; Saragovi, H Uri; Burgess, KevinACS chemical biology2009 Sep 18769-8119735123
Quantitative detection of bioassays with a low-cost image-sensor array for integrated microsystems.Vykoukal, Daynene M; Stone, Gregory P; Gascoyne, Peter R C; Alt, Eckhard U; Vykoukal, JodyAngewandte Chemie (International ed. in English)20097649-5419735080
Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles.Noel, Romain; Song, Xinyi; Jiang, Rong; Chalmers, Michael J; Griffin, Patrick R; Kamenecka, Theodore MThe Journal of organic chemistry2009 Oct 27595-719731897
Palladium- and copper-catalyzed solution phase synthesis of a diverse library of isoquinolines.Roy, Sudipta; Roy, Sujata; Neuenswander, Benjamin; Hill, David; Larock, Richard CJournal of combinatorial chemistry2009 Nov-Dec1061-519728736
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.Kapur, Ankur; Zhao, Pingwei; Sharir, Haleli; Bai, Yushi; Caron, Marc G; Barak, Larry S; Abood, Mary EThe Journal of biological chemistry2009 Oct 2329817-2719723626
Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.Castaldi, M Paola; Troast, Dawn M; Porco Jr, John AOrganic letters2009 Aug 63362-519719184
Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.Motlekar, Nuzhat; de Almeida, Rogerio Alves; Pavitt, Graham D; Diamond, Scott L; Napper, Andrew DAssay and drug development technologies2009 Oct479-9419715453
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.Kwan, Jason C; Eksioglu, Erika A; Liu, Chen; Paul, Valerie J; Luesch, HendrikJournal of medicinal chemistry2009 Sep 245732-4719715320
Condensation reactions to form oxazoline-substituted potassium organotrifluoroborates.Molander, Gary A; Febo-Ayala, Wilma; Jean-Gerard, LudivineOrganic letters2009 Sep 33830-319708697
High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.Lewis, L Michelle; Bhave, Gautam; Chauder, Brian A; Banerjee, Sreedatta; Lornsen, Katharina A; Redha, Rey; Fallen, Katherine; Lindsley, Craig W; Weaver, C David; Denton, Jerod SMolecular pharmacology2009 Nov1094-10319706730
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.Sidique, Shyama; Shiryaev, Sergey A; Ratnikov, Boris I; Herath, Ananda; Su, Ying; Strongin, Alex Y; Cosford, Nicholas D PBioorganic & medicinal chemistry letters2009 Oct 15773-719703770
Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.Milinkevich, Kristin A; Yoo, Choong L; Sparks, Thomas C; Lorsbach, Beth A; Kurth, Mark JBioorganic & medicinal chemistry letters2009 Oct 15796-819700317
Partially nanofibrous architecture of 3D tissue engineering scaffolds.Wei, Guobao; Ma, Peter XBiomaterials2009 Nov6426-3419699518
Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer.Lupo, Janine M; Chen, Albert P; Zierhut, Matthew L; Bok, Robert A; Cunningham, Charles H; Kurhanewicz, John; Vigneron, Daniel B; Nelson, Sarah JMagnetic resonance imaging2010 Feb153-6219695815
Small molecule DnaK modulators targeting the beta-domain.Cellitti, Jason; Zhang, Ziming; Wang, Si; Wu, Bainan; Yuan, Hongbin; Hasegawa, Patty; Guiney, Donald G; Pellecchia, MaurizioChemical biology & drug design2009 Oct349-5719694756
Palladium-catalyzed decarboxylative rearrangements of allyl 2,2,2-trifluoroethyl malonates: direct access to homoallylic esters.Tardibono Jr, Lawrence P; Patzner, Jerod; Cesario, Cara; Miller, Marvin JOrganic letters2009 Sep 174076-919694457
PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif.Chung, Jean-Ju; Okamoto, Yukari; Coblitz, Brian; Li, Min; Qiu, Yun; Shikano, SojinThe FEBS journal2009 Oct5547-5819691494
The receptor-dependent QSAR paradigm: an overview of the current state of the art.Santos-Filho, Osvaldo A; Hopfinger, Anton J; Cherkasov, Artem; de Alencastro, Ricardo BiccaMedicinal chemistry (Shariqah (United Arab Emirates))2009 Jul359-6619689393
Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones.Pudelova, Nadezda; Krchnak, ViktorJournal of combinatorial chemistry2009 Sep-Oct851-919689103
Plasmonics of 3-D nanoshell dimers using multipole expansion and finite element method.Khoury, Christopher G; Norton, Stephen J; Vo-Dinh, TuanACS nano2009 Sep 222776-8819678677
Marinopyrrole A target elucidation by acyl dye transfer.Hughes, Chambers C; Yang, Yu-Liang; Liu, Wei-Ting; Dorrestein, Pieter C; La Clair, James J; Fenical, WilliamJournal of the American Chemical Society2009 Sep 212094-619673475
Imaging engineered tissues using structural and functional optical coherence tomography.Liang, Xing; Graf, Benedikt W; Boppart, Stephen AJournal of biophotonics2009 Nov643-5519672880
A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents.Zhu, Hao; Ye, Lin; Richard, Ann; Golbraikh, Alexander; Wright, Fred A; Rusyn, Ivan; Tropsha, AlexanderEnvironmental health perspectives2009 Aug1257-6419672406
Next-generation quantum dots.Smith, Andrew M; Nie, ShumingNature biotechnology2009 Aug732-319668181
Synthesis of 3-sulfenyl- and 3-selenylindoles by the Pd/Cu-catalyzed coupling of N,N-dialkyl-2-iodoanilines and terminal alkynes, followed by n-Bu(4)NI-induced electrophilic cyclization.Chen, Yu; Cho, Chul-Hee; Shi, Feng; Larock, Richard CThe Journal of organic chemistry2009 Sep 46802-1119663396
Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.Kikuchi, Koji; Abdel-Aziz, H Ismail; Taniguchi, Yoshihito; Yamazoe, Mitsuyoshi; Takeda, Shunichi; Hirota, KoujiThe Journal of biological chemistry2009 Sep 2526360-719661064
PET imaging of leptin biodistribution and metabolism in rodents and primates.Ceccarini, Giovanni; Flavell, Robert R; Butelman, Eduardo R; Synan, Michael; Willnow, Thomas E; Bar-Dagan, Maya; Goldsmith, Stanley J; Kreek, Mary J; Kothari, Paresh; Vallabhajosula, Shankar; Muir, Tom W; Friedman, Jeffrey MCell metabolism2009 Aug148-5919656493
Demonstration of surface-enhanced Raman scattering by tunable, plasmonic gallium nanoparticles.Wu, Pae C; Khoury, Christopher G; Kim, Tong-Ho; Yang, Yang; Losurdo, Maria; Bianco, Giuseppe V; Vo-Dinh, Tuan; Brown, April S; Everitt, Henry OJournal of the American Chemical Society2009 Sep 212032-319655747
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.Milan, David J; Kim, Albert M; Winterfield, Jeffrey R; Jones, Ian L; Pfeufer, Arne; Sanna, Serena; Arking, Dan E; Amsterdam, Adam H; Sabeh, Khaled M; Mably, John D; Rosenbaum, David S; Peterson, Randall T; Chakravarti, Aravinda; Kaab, Stefan; Roden, Dan MCirculation2009 Aug 18553-919652097
A peptidomimetic of NT-3 acts as a TrkC antagonist.Brahimi, Fouad; Malakhov, Andrey; Lee, Hong Boon; Pattarawarapan, Mookda; Ivanisevic, Lubijca; Burgess, Kevin; Saragovi, H UriPeptides2009 Oct1833-919647025
Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic system.Wu, Meng; Long, Shunyou; Frutos, Anthony G; Eichelberger, Maryna; Li, Min; Fang, YeJournal of receptor and signal transduction research2009202-1019640222
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.Zou, Wei; Beggs, Kevin M; Sparkenbaugh, Erica M; Jones, A Daniel; Younis, Husam S; Roth, Robert A; Ganey, Patricia EThe Journal of pharmacology and experimental therapeutics2009 Oct114-2119638570
Stereoselective synthesis of benzannulated spiroketals: influence of the aromatic ring on reactivity and conformation.Liu, Guodong; Wurst, Jacqueline M; Tan, Derek SOrganic letters2009 Aug 203670-319634891
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.Bugreev, Dmitry V; Mazina, Olga M; Mazin, Alexander VThe Journal of biological chemistry2009 Sep 2526349-5919632996
Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: a double diversity for the identification of new antitubercular compounds.Nefzi, Adel; Appel, Jon; Arutyunyan, Sergey; Houghten, Richard ABioorganic & medicinal chemistry letters2009 Sep 15169-7519632841
Changes in lipid-encapsulated microbubble population during continuous infusion and methods to maintain consistency.Kaya, Mehmet; Gregory 5th, Thomas S; Dayton, Paul AUltrasound in medicine & biology2009 Oct1748-5519632760
3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity.Yu, Gui J; Iwamoto, Satori; Robins, Lori I; Fettinger, James C; Sparks, Thomas C; Lorsbach, Beth A; Kurth, Mark JJournal of agricultural and food chemistry2009 Aug 267422-619624156
KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo.Clancy, Sinead M; Chen, Bihan; Bertaso, Federica; Mamet, Julien; Jegla, TimothyPloS one2009e633019623261
Tunable machine vision-based strategy for automated annotation of chemical databases.Park, Jungkap; Rosania, Gus R; Saitou, KazuhiroJournal of chemical information and modeling2009 Aug1993-200119621901
In vivo MRI cell tracking: clinical studies.Bulte, Jeff W MAJR. American journal of roentgenology2009 Aug314-2519620426
Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors.Wang, Qi; Mach, Robert H; Reichert, David EJournal of chemical information and modeling2009 Aug1963-7319610597
Theory-Guided Design of Bronsted Acid-Assisted Phosphine Catalysis: Synthesis of Dihydropyrones from Aldehydes and Allenoates.Creech, Gardner S; Zhu, Xue-Feng; Fonovic, Branden; Dudding, Travis; Kwon, OhyunTetrahedron2008 Jul 146935-694219606204
Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells.Du, Yuhong; Li, Zijian; Li, Lian; Chen, Zhuo Georgia; Sun, Shi-Yong; Chen, Peifang; Shin, Dong M; Khuri, Fadlo R; Fu, HaianJournal of receptor and signal transduction research2009182-9419604037
Domino Heck-Aza-Michael Reactions: A One-Pot, Sequential Three-Component Approach to 1,1-Dioxido-1,2-benzisothiazoline-3-acetic Acid.Rolfe, Alan; Young, Kyle; Hanson, Paul REuropean journal of organic chemistry20085254-526219603087
Dereplication and de novo sequencing of nonribosomal peptides.Ng, Julio; Bandeira, Nuno; Liu, Wei-Ting; Ghassemian, Majid; Simmons, Thomas L; Gerwick, William H; Linington, Roger; Dorrestein, Pieter C; Pevzner, Pavel ANature methods2009 Aug596-919597502
Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli.Watanabe, Kenji; Hotta, Kinya; Praseuth, Alex P; Searcey, Mark; Wang, Clay C C; Oguri, Hiroki; Oikawa, HideakiChembiochem : a European journal of chemical biology2009 Aug 171965-819588480
Photophysics and stability of cyano-substituted boradiazaindacene dyes.Cieýýlik-Boczula, Katarzyna; Burgess, Kevin; Li, Lingling; Nguyen, Binh; Pandey, Lesley; De Borggraeve, Wim M; Van der Auweraer, Mark; Boens, NoelPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2009 Jul1006-1519582277
Divalent cations slow activation of EAG family K+ channels through direct binding to S4.Zhang, Xiaofei; Bursulaya, Badry; Lee, Christian C; Chen, Bihan; Pivaroff, Kendra; Jegla, TimothyBiophysical journal2009 Jul 8110-2019580749
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.Molina, Gabriela; Vogt, Andreas; Bakan, Ahmet; Dai, Weixiang; Queiroz de Oliveira, Pierre; Znosko, Wade; Smithgall, Thomas E; Bahar, Ivet; Lazo, John S; Day, Billy W; Tsang, MichaelNature chemical biology2009 Sep680-719578332
Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.Ivnitski-Steele, Irena; Holmes, Ann R; Lamping, Erwin; Monk, Brian C; Cannon, Richard D; Sklar, Larry AAnalytical biochemistry2009 Nov 187-9119577533
Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.Lauer-Fields, Janelle L; Chalmers, Michael J; Busby, Scott A; Minond, Dmitriy; Griffin, Patrick R; Fields, Gregg BThe Journal of biological chemistry2009 Sep 424017-2419574232
A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase.Foley, Timothy L; Burkart, Michael DAnalytical biochemistry2009 Nov 139-4719573516
Solution-phase parallel synthesis of a multi-substituted benzo[b]thiophene library.Cho, Chul-Hee; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard CJournal of combinatorial chemistry2009 Sep-Oct900-619569714
The role of transporters in the pharmacokinetics of orally administered drugs.Shugarts, Sarah; Benet, Leslie ZPharmaceutical research2009 Sep2039-5419568696
Fluorescent cassettes for monitoring three-component interactions in vitro and in living cells.Wu, Liangxing; Loudet, Aurore; Barhoumi, Rola; Burghardt, Robert C; Burgess, KevinJournal of the American Chemical Society2009 Jul 89156-719566090
Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network.Hu, Jiang; Feng, Kai; Liu, Xiaohua; Ma, Peter XBiomaterials2009 Oct5061-719564041
Exocytosis of post-Golgi vesicles is regulated by components of the endocytic machinery.Jaiswal, Jyoti K; Rivera, Victor M; Simon, Sanford MCell2009 Jun 261308-1919563761
Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support.Sun, Y S; Landry, J P; Fei, Y Y; Zhu, X D; Luo, J T; Wang, X B; Lam, K SAnalytical chemistry2009 Jul 15373-8019563213
Systems approach to explore components and interactions in the presynapse.Abul-Husn, Noura S; Bushlin, Ittai; Moron, Jose A; Jenkins, Sherry L; Dolios, Georgia; Wang, Rong; Iyengar, Ravi; Ma'ayan, Avi; Devi, Lakshmi AProteomics2009 Jun3303-1519562802
Interactive exploration of chemical space with Scaffold Hunter.Wetzel, Stefan; Klein, Karsten; Renner, Steffen; Rauh, Daniel; Oprea, Tudor I; Mutzel, Petra; Waldmann, HerbertNature chemical biology2009 Aug581-319561620
Bioactivity-guided mapping and navigation of chemical space.Renner, Steffen; van Otterlo, Willem A L; Dominguez Seoane, Marta; Mocklinghoff, Sabine; Hofmann, Bettina; Wetzel, Stefan; Schuffenhauer, Ansgar; Ertl, Peter; Oprea, Tudor I; Steinhilber, Dieter; Brunsveld, Luc; Rauh, Daniel; Waldmann, HerbertNature chemical biology2009 Aug585-9219561619
Assay development and high-throughput antiviral drug screening against Bluetongue virus.Li, Qianjun; Maddox, Clinton; Rasmussen, Lynn; Hobrath, Judith V; White, Lucile EAntiviral research2009 Sep267-7319559054
Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.Sergienko, Eduard; Su, Ying; Chan, Xochella; Brown, Brock; Hurder, Andrew; Narisawa, Sonoko; Millan, Jose LuisJournal of biomolecular screening2009 Aug824-3719556612
An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.Ostrovsky, Olga; Makarewich, Catherine A; Snapp, Erik L; Argon, YairProceedings of the National Academy of Sciences of the United States of America2009 Jul 1411600-519553200
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries.Minond, Dmitriy; Saldanha, S Adrian; Subramaniam, Prem; Spaargaren, Michael; Spicer, Timothy; Fotsing, Joseph R; Weide, Timo; Fokin, Valery V; Sharpless, K Barry; Galleni, Moreno; Bebrone, Carine; Lassaux, Patricia; Hodder, PeterBioorganic & medicinal chemistry2009 Jul 155027-3719553129
Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.Choi, Yongmun; Syeda, Farisa; Walker, John R; Finerty Jr, Patrick J; Cuerrier, Dominic; Wojciechowski, Amy; Liu, Qingsong; Dhe-Paganon, Sirano; Gray, Nathanael SBioorganic & medicinal chemistry letters2009 Aug 14467-7019553108
Syntheses and biological activity studies of novel sterol analogs from nitroso Diels-Alder reactions of ergosterol.Yang, Baiyuan; Miller, Patricia A; Mollmann, Ute; Miller, Marvin JOrganic letters2009 Jul 22828-3119552465
The chemical biology of modular biosynthetic enzymes.Meier, Jordan L; Burkart, Michael DChemical Society reviews2009 Jul2012-4519551180
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.Tsvilovskyy, Volodymyr V; Zholos, Alexander V; Aberle, Thomas; Philipp, Stephan E; Dietrich, Alexander; Zhu, Michael X; Birnbaumer, Lutz; Freichel, Marc; Flockerzi, VeitGastroenterology2009 Oct1415-2419549525
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.Peterson, Yuri K; Wang, Xiang S; Casey, Patrick J; Tropsha, AlexanderJournal of medicinal chemistry2009 Jul 234210-2019537691
A crowdsourcing evaluation of the NIH chemical probes.Oprea, Tudor I; Bologa, Cristian G; Boyer, Scott; Curpan, Ramona F; Glen, Robert C; Hopkins, Andrew L; Lipinski, Christopher A; Marshall, Garland R; Martin, Yvonne C; Ostopovici-Halip, Liliana; Rishton, Gilbert; Ursu, Oleg; Vaz, Roy J; Waller, Chris; WaldNature chemical biology2009 Jul441-719536101
The role of amphiphilicity and negative charge in glycoprotein 41 interactions in the hydrophobic pocket.Gochin, Miriam; Cai, LifengJournal of medicinal chemistry2009 Jul 234338-4419534533
Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors.Roman, David L; Ota, Shodai; Neubig, Richard RJournal of biomolecular screening2009 Jul610-919531661
Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.Johnston, Paul A; Foster, Caleb A; Tierno, Marni Brisson; Shun, Tong Ying; Shinde, Sunita N; Paquette, William D; Brummond, Kay M; Wipf, Peter; Lazo, John SAssay and drug development technologies2009 Jun250-6519530895
Intermodal four-wave mixing from femtosecond pulse-pumped photonic crystal fiber.Tu, H; Jiang, Z; Marks, D L; Boppart, S AApplied physics letters2009 Mar 910110919529787
Polymeric nanomedicine for cancer MR imaging and drug delivery.Khemtong, Chalermchai; Kessinger, Chase W; Gao, JinmingChemical communications (Cambridge, England)2009 Jun 283497-51019521593
Plasmonic nanoprobes for SERS biosensing and bioimaging.Vo-Dinh, Tuan; Wang, Hsin-Neng; Scaffidi, JonathanJournal of biophotonics2010 Jan89-10219517422
The natural history of antibiotics.Clardy, Jon; Fischbach, Michael A; Currie, Cameron RCurrent biology : CB2009 Jun 9R437-4119515346
Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.Watanabe, Kenji; Hotta, Kinya; Nakaya, Mino; Praseuth, Alex P; Wang, Clay C C; Inada, Daiki; Takahashi, Kosaku; Fukushi, Eri; Oguri, Hiroki; Oikawa, HideakiJournal of the American Chemical Society2009 Jul 89347-5319514719
Optical frequency up-conversion by supercontinuum-free widely-tunable fiber-optic Cherenkov radiation.Tu, Haohua; Boppart, Stephen AOptics express2009 Jun 89858-7219506636
One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acids.Rolfe, Alan; Young, Kyle; Volp, Kelly; Schoenen, Frank; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul RJournal of combinatorial chemistry2009 Jul-Aug732-819505109
Adapting Cell-Based Assays to the High Throughput Screening Platform: Problems Encountered and Lessons Learned.Maddox, Clinton B; Rasmussen, Lynn; White, E LucileJALA (Charlottesville, Va.)2008 Jun168-17319492073
Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds.Liu, Xiaohua; Ma, Peter XBiomaterials2009 Sep4094-10319481080
Chapter 11. Subsecond analyses of G-protein coupled-receptor ternary complex dynamics by rapid mix flow cytometry.Buranda, Tione; Wu, Yang; Sklar, Larry AMethods in enzymology2009227-4719480922
Unconventional 2D shape similarity method affords comparable enrichment as a 3D shape method in virtual screening experiments.Ebalunode, Jerry Osagie; Zheng, WeifanJournal of chemical information and modeling2009 Jun1313-2019480404
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.Haynes, Mark K; Strouse, J Jacob; Waller, Anna; Leitao, Andrei; Curpan, Ramona F; Bologa, Cristian; Oprea, Tudor I; Prossnitz, Eric R; Edwards, Bruce S; Sklar, Larry A; Thompson, Todd AJournal of biomolecular screening2009 Jul596-60919470718
Mechanisms of estrogen signaling and gene expression via GPR30.Prossnitz, Eric R; Maggiolini, MarcelloMolecular and cellular endocrinology2009 Sep 2432-819464786
Functionalized BF(2) Chelated Azadipyrromethene Dyes.Loudet, Aurore; Bandichhor, Rakeshwar; Wu, Liangxing; Burgess, KevinTetrahedron2008 Apr 213642-365419458781
Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy.Hettiarachchi, Kanaka; Zhang, Shirley; Feingold, Steven; Lee, Abraham P; Dayton, Paul ABiotechnology progress2009 Jul-Aug938-4519455647
Stimuli-responsive SERS nanoparticles: conformational control of plasmonic coupling and surface Raman enhancement.Qian, Ximei; Li, Jun; Nie, ShumingJournal of the American Chemical Society2009 Jun 107540-119453179
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.Pound, Lynley D; Sarkar, Suparna A; Benninger, Richard K P; Wang, Yingda; Suwanichkul, Adisak; Shadoan, Melanie K; Printz, Richard L; Oeser, James K; Lee, Catherine E; Piston, David W; McGuinness, Owen P; Hutton, John C; Powell, David R; O'Brien, Richard The Biochemical journal2009 Aug 1371-619450229
Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER.Prossnitz, Eric R; Barton, MatthiasProstaglandins & other lipid mediators2009 Sep89-9719442754
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.Bridges, Thomas M; Marlo, Joy E; Niswender, Colleen M; Jones, Carrie K; Jadhav, Satyawan B; Gentry, Patrick R; Plumley, Hyekyung C; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig WJournal of medicinal chemistry2009 Jun 113445-819438238
Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns.Volchenboum, Samuel L; Kristjansdottir, Kolbrun; Wolfgeher, Donald; Kron, Stephen JMolecular & cellular proteomics : MCP2009 Aug2011-2219435713
Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography.Ahmad, Adeel; Adie, Steven G; Chaney, Eric J; Sharma, Utkarsh; Boppart, Stephen AOptics express2009 May 118125-3619434144
Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa.Meickle, Theresa; Matthew, Susan; Ross, Cliff; Luesch, Hendrik; Paul, ValeriePlanta medica2009 Oct1427-3019431099
In vivo effects of a GPR30 antagonist.Dennis, Megan K; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Alcon, Sara N; Nayak, Tapan K; Bologa, Cristian G; Leitao, Andrei; Brailoiu, Eugen; Deliu, Elena; Dun, Nae J; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Oprea, Tudor I; PNature chemical biology2009 Jun421-719430488
Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes.Wang, Hsin-Neng; Vo-Dinh, TuanNanotechnology2009 Feb 1106510119417369
In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I.Lu, Jie; Chan, Lai; Fiji, Hannah D G; Dahl, Russell; Kwon, Ohyun; Tamanoi, FuyuhikoMolecular cancer therapeutics2009 May1218-2619417142
Probing marine natural product defenses with DESI-imaging mass spectrometry.Esquenazi, Eduardo; Dorrestein, Pieter C; Gerwick, William HProceedings of the National Academy of Sciences of the United States of America2009 May 57269-7019416917
"To learn, you must pay attention." Molecular insights into teachers' wisdom.Caron, Marc G; Wightman, R MarkProceedings of the National Academy of Sciences of the United States of America2009 May 57267-819416916
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.Blue, Robert; Kowalska, M Anna; Hirsch, Jessica; Murcia, Marta; Janczak, Christin A; Harrington, Amanda; Jirouskova, Marketa; Li, Jihong; Fuentes, Rudy; Thornton, Michael A; Filizola, Marta; Poncz, Mortimer; Coller, Barry SBlood2009 Jul 2195-20119414864
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides.Liu, Wei-Ting; Ng, Julio; Meluzzi, Dario; Bandeira, Nuno; Gutierrez, Marcelino; Simmons, Thomas L; Schultz, Andrew W; Linington, Roger G; Moore, Bradley S; Gerwick, William H; Pevzner, Pavel A; Dorrestein, Pieter CAnalytical chemistry2009 Jun 14200-919413302
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.Sheffler, Douglas J; Williams, Richard; Bridges, Thomas M; Xiang, Zixiu; Kane, Alexander S; Byun, Nellie E; Jadhav, Satyawan; Mock, Mathew M; Zheng, Fang; Lewis, L Michelle; Jones, Carrie K; Niswender, Colleen M; Weaver, Charles D; Lindsley, Craig W; ConnMolecular pharmacology2009 Aug356-6819407080
Application of the "libraries from libraries" concept to "one-bead one-compound" combinatorial chemistry.Kappel, Joseph C; Fan, Yi C; Lam, Kit SAdvances in experimental medicine and biology200921-219400077
Effects of drug transporters on volume of distribution.Grover, Anita; Benet, Leslie ZThe AAPS journal2009 Jun250-6119399628
Trace amine-associated receptors as emerging therapeutic targets.Sotnikova, Tatyana D; Caron, Marc G; Gainetdinov, Raul RMolecular pharmacology2009 Aug229-3519389919
NAADP mobilizes calcium from acidic organelles through two-pore channels.Calcraft, Peter J; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N; ParrinNature2009 May 28596-60019387438
Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells.Zhang, Sharon S; Hao, Ergeng; Yu, Jianxiu; Liu, Wen; Wang, Jing; Levine, Fred; Feng, Gen-ShengProceedings of the National Academy of Sciences of the United States of America2009 May 57531-619380737
Phosphine-promoted [3 + 3] annulations of aziridines with allenoates: facile entry into highly functionalized tetrahydropyridines.Guo, Hongchao; Xu, Qihai; Kwon, OhyunJournal of the American Chemical Society2009 May 136318-919374356
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.Mo, Shunyan; Krunic, Aleksej; Chlipala, George; Orjala, JimmyJournal of natural products2009 May 22894-919371071
Design and synthesis of a library of tetracyclic hydroazulenoisoindoles.Brummond, Kay M; Mao, Shuli; Shinde, Sunita N; Johnston, Paul J; Day, Billy WJournal of combinatorial chemistry2009 May-Jun486-9419366169
Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors.Cai, Lifeng; Balogh, Edina; Gochin, MiriamAntimicrobial agents and chemotherapy2009 Jun2444-919364877
Photoconversion in orange and red fluorescent proteins.Kremers, Gert-Jan; Hazelwood, Kristin L; Murphy, Christopher S; Davidson, Michael W; Piston, David WNature methods2009 May355-819363494
Polymer-supported alpha-acylamino ketones: preparation and application in syntheses of 1,2,4-trisubstituted-1H-imidazoles.Koci, Jan; Pudelova, Nadýýzda; Krchnak, ViktorJournal of combinatorial chemistry2009 May-Jun397-40219354277
Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots.Rappoport, Joshua Z; Simon, Sanford MJournal of cell science2009 May 11301-519351721
Zebrafish genetic models for arrhythmia.Milan, David J; Macrae, Calum AProgress in biophysics and molecular biology2008 Oct-Nov301-819351520
Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking.Easley, Christopher J; Benninger, Richard K P; Shaver, Jesse H; Steven Head, W; Piston, David WLab on a chip2009 Apr 211119-2719350094
Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ.Perkins, Guy A; Sun, Mei G; Frey, Terrence GMethods in enzymology200929-5219348881
Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects.Woo, Kyung Mi; Chen, Victor J; Jung, Hong-Moon; Kim, Tae-Il; Shin, Hong-In; Baek, Jeong-Hwa; Ryoo, Hyun-Mo; Ma, Peter XTissue engineering. Part A2009 Aug2155-6219348597
High-throughput real-time PCR for detection of gene-expression levels.Wagner, Bridget K; Arany, ZoltanMethods in molecular biology (Clifton, N.J.)2009167-7519347623
High-content screening: flow cytometry analysis.Edwards, Bruce S; Young, Susan M; Ivnitsky-Steele, Irena; Ye, Richard D; Prossnitz, Eric R; Sklar, Larry AMethods in molecular biology (Clifton, N.J.)2009151-6519347622
Assay for isolation of inhibitors of her2-kinase expression.Chiosis, Gabriela; Keeton, Adam BMethods in molecular biology (Clifton, N.J.)2009139-4919347621
Cell-based assays to probe the ERK MAP kinase pathway in endothelial cells.Wyler, Michael R; Smith, Deborah H; Cayanis, Eftihia; Tobben, Udo; Aulner, Nathalie; Mayer, ThomasMethods in molecular biology (Clifton, N.J.)200929-4119347614
A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans.Pungaliya, Chirag; Srinivasan, Jagan; Fox, Bennett W; Malik, Rabia U; Ludewig, Andreas H; Sternberg, Paul W; Schroeder, Frank CProceedings of the National Academy of Sciences of the United States of America2009 May 127708-1319346493
Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis.Hur, Gene H; Meier, Jordan L; Baskin, Jeremy; Codelli, Julian A; Bertozzi, Carolyn R; Marahiel, Mohamed A; Burkart, Michael DChemistry & biology2009 Apr 24372-8119345117
Fuel specificity of the hepatitis C virus NS3 helicase.Belon, Craig A; Frick, David NJournal of molecular biology2009 May 15851-6419332076
Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R; Clardy, JonNature chemical biology2009 Jun391-319330011
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.Bachovchin, Daniel A; Brown, Steven J; Rosen, Hugh; Cravatt, Benjamin FNature biotechnology2009 Apr387-9419329999
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert HJournal of medicinal chemistry2009 Apr 232188-9119326941
Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines.Tardibono, Lawrence P; Miller, Marvin JOrganic letters2009 Apr 21575-819320504
Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists.Doghman, Mabrouka; Cazareth, Julie; Douguet, Dominique; Madoux, Franck; Hodder, Peter; Lalli, EnzoThe Journal of clinical endocrinology and metabolism2009 Jun2178-8319318454
Synthesis of a cross-linked branched polymer network in the interior of a protein cage.Abedin, Md Joynal; Liepold, Lars; Suci, Peter; Young, Mark; Douglas, TrevorJournal of the American Chemical Society2009 Apr 14346-5419317506
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.Patel, Vishal; Mazitschek, Ralph; Coleman, Bradley; Nguyen, Cokey; Urgaonkar, Sameer; Cortese, Joseph; Barker, Robert H; Greenberg, Edward; Tang, Weiping; Bradner, James E; Schreiber, Stuart L; Duraisingh, Manoj T; Wirth, Dyann F; Clardy, JonJournal of medicinal chemistry2009 Apr 232185-719317450
In vivo modification of native carrier protein domains.Mercer, Andrew C; Meier, Jordan L; Torpey, Justin W; Burkart, Michael DChembiochem : a European journal of chemical biology2009 Apr 171091-10019308927
The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.Geng, Yang; Hoke, Ahmet; Delpire, EricThe Journal of biological chemistry2009 May 2214020-819307180
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.Xie, Yuli; Liu, Yidong; Gong, Gangli; Smith, Deborah H; Yan, Fang; Rinderspacher, Alison; Feng, Yan; Zhu, Zhengxiang; Li, Xiangpo; Deng, Shi-Xian; Branden, Lars; Vidovic, Dusica; Chung, Caty; Schurer, Stephan; Morisseau, Christophe; Hammock, Bruce D; LandBioorganic & medicinal chemistry letters2009 Apr 152354-919303288
[18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.Zhou, Dong; Chu, Wenhua; Chen, Delphine L; Wang, Qi; Reichert, David E; Rothfuss, Justin; D'Avignon, Andre; Welch, Michael J; Mach, Robert HOrganic & biomolecular chemistry2009 Apr 71337-4819300818
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules.Marsolais, David; Rosen, HughNature reviews. Drug discovery2009 Apr297-30719300460
Using biological performance similarity to inform disaccharide library design.Tanikawa, Tetsuya; Fridman, Micha; Zhu, Wenjiang; Faulk, Brian; Joseph, Isaac C; Kahne, Daniel; Wagner, Bridget K; Clemons, Paul AJournal of the American Chemical Society2009 Apr 155075-8319298063
Nanohole arrays of mixed designs and microwriting for simultaneous and multiple protein binding studies.Ji, Jin; Yang, Jiun-Chan; Larson, Dale NBiosensors & bioelectronics2009 May 152847-5219297143
Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors.Andrade, Carolina H; Pasqualoto, Kerly F M; Ferreira, Elizabeth I; Hopfinger, Anton JJournal of chemical information and modeling2009 Apr1070-819296716
Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.Li, Xiaohai; He, Yuanjun; Ruiz, Claudia H; Koenig, Marcel; Cameron, Michael D; Vojkovsky, TomasDrug metabolism and disposition: the biological fate of chemicals2009 Jun1242-5019282395
Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy.Madani, Fatemeh; Lind, Jesper; Damberg, Peter; Adams, Stephen R; Tsien, Roger Y; Graslund, Astrid OJournal of the American Chemical Society2009 Apr 84613-519281235
Affinity of drugs and small biologically active molecules to carbon nanotubes: a pharmacodynamics and nanotoxicity factor?Liu, John; Yang, Liu; Hopfinger, Anton JMolecular pharmaceutics2009 May-Jun873-8219281188
Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.Delpire, Eric; Days, Emily; Lewis, L Michelle; Mi, Dehui; Kim, Kwangho; Lindsley, Craig W; Weaver, C DavidProceedings of the National Academy of Sciences of the United States of America2009 Mar 315383-819279215
Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.Wilson, David M; Hurd, Ralph E; Keshari, Kayvan; Van Criekinge, Mark; Chen, Albert P; Nelson, Sarah J; Vigneron, Daniel B; Kurhanewicz, JohnProceedings of the National Academy of Sciences of the United States of America2009 Apr 75503-719276112
Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.Ji, Zhenyu; Mei, Fang C; Lory, Pedro L; Gilbertson, Scott R; Chen, Yijun; Cheng, XiaodongFrontiers in bioscience : a journal and virtual library20092904-1019273243
Novel chemical space exploration via natural products.Rosen, Josefin; Gottfries, Johan; Muresan, Sorel; Backlund, Anders; Oprea, Tudor IJournal of medicinal chemistry2009 Apr 91953-6219265440
Efficient traceless solid-phase synthesis of 3,4-dihydropyrazino[1,2-b]indazoles and their 6-oxides.Pudelova, Nadezda; Krchnak, ViktorJournal of combinatorial chemistry2009 May-Jun370-419245249
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.Rinderspacher, Alison; Cremona, Maria Laura; Liu, Yidong; Deng, Shi-Xian; Xie, Yuli; Gong, Gangli; Aulner, Nathalie; Tobben, Udo; Myers, Katherine; Chung, Caty; Andersen, Monique; Vidovic, Dusica; Schurer, Stephan; Branden, Lars; Yamamoto, Ai; Landry, DonBioorganic & medicinal chemistry letters2009 Mar 151715-719243939
Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes.Shedden, Kerby; Li, Qian; Liu, Fangyi; Chang, Young Tae; Rosania, Gus RCytometry. Part A : the journal of the International Society for Analytical Cytology2009 Jun482-9319243023
Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.Bialkowska, Agnieszka B; Du, Yuhong; Fu, Haian; Yang, Vincent WMolecular cancer therapeutics2009 Mar563-7019240162
Expression order of alpha-v and beta-3 integrin subunits in the N-methyl-N-nitrosourea-induced rat mammary tumor model.Rezaeipoor, Robabeh; Chaney, Eric J; Oldenburg, Amy L; Boppart, Stephen ACancer investigation2009 Jun496-50319234941
Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios.Mehrotra, Sumit; Lee, Ilsoon; Chan, ChristinaActa biomaterialia2009 Jun1474-8819217360
In vivo tracking of cellular therapeutics using magnetic resonance imaging.Long, Christoper M; Bulte, Jeff W MExpert opinion on biological therapy2009 Mar293-30619216619
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.Mustata, Gabriela; Follis, Ariele Viacava; Hammoudeh, Dalia I; Metallo, Steven J; Wang, Huabo; Prochownik, Edward V; Lazo, John S; Bahar, IvetJournal of medicinal chemistry2009 Mar 121247-5019215087
Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides.Matthew, Susan; Paul, Valerie J; Luesch, HendrikPlanta medica2009 Apr528-3319214948
Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors.Abdullah, Newaj M; Rosania, Gus R; Shedden, KerbyPloS one2009e447019214225
Improving the efficiency of biomarker identification using biological knowledge.Phan, John H; Yin-Goen, Qiqin; Young, Andrew N; Wang, May DPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2009427-3819209720
NMR second site screening for structure determination of ligands bound in the hydrophobic pocket of HIV-1 gp41.Balogh, Edina; Wu, Dong; Zhou, Guangyan; Gochin, MiriamJournal of the American Chemical Society2009 Mar 42821-319206471
Zinc activates damage-sensing TRPA1 ion channels.Hu, Hongzhen; Bandell, Michael; Petrus, Matt J; Zhu, Michael X; Patapoutian, ArdemNature chemical biology2009 Mar183-9019202543
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.Conn, P Jeffrey; Jones, Carrie K; Lindsley, Craig WTrends in pharmacological sciences2009 Mar148-5519201489
Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.Wright, Christine M; Seguin, Sandlin P; Fewell, Sheara W; Zhang, Haijiang; Ishwad, Chandra; Vats, Abhay; Lingwood, Clifford A; Wipf, Peter; Fanning, Ellen; Pipas, James M; Brodsky, Jeffrey LVirus research2009 Apr71-8019200446
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.Wieland Brown, Laura C; Acker, Michael G; Clardy, Jon; Walsh, Christopher T; Fischbach, Michael AProceedings of the National Academy of Sciences of the United States of America2009 Feb 242549-5319196969
Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy.Marshall, Wallace FJournal of biomolecular screening2009 Feb133-4119196701
A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding.Gunther, Jillian R; Du, Yuhong; Rhoden, Eric; Lewis, Iestyn; Revennaugh, Brian; Moore, Terry W; Kim, Sung Hoon; Dingledine, Raymond; Fu, Haian; Katzenellenbogen, John AJournal of biomolecular screening2009 Feb181-9319196699
Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers.Smith, Laura A; Liu, Xiaohua; Hu, Jiang; Wang, Peng; Ma, Peter XTissue engineering. Part A2009 Jul1855-6419196152
Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.Praseuth, Alex P; Wang, Clay C C; Watanabe, Kenji; Hotta, Kinya; Oguri, Hiroki; Oikawa, HideakiBiotechnology progress2008 Nov-Dec1226-3119194935
In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles.Khemtong, Chalermchai; Kessinger, Chase W; Ren, Jimin; Bey, Erik A; Yang, Su-Geun; Guthi, Jagadeesh Setti; Boothman, David A; Sherry, A Dean; Gao, JinmingCancer research2009 Feb 151651-819190328
Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles.Gilad, Assaf A; van Laarhoven, Hanneke W M; McMahon, Michael T; Walczak, Piotr; Heerschap, Arend; Neeman, Michal; van Zijl, Peter C M; Bulte, Jeff W MMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine2009 Apr970-419189296
Versatile horizontal force probe for mechanical tests on pipette-held cells, particles, and membrane capsules.Ounkomol, Chawin; Xie, Hongtao; Dayton, Paul A; Heinrich, VolkmarBiophysical journal2009 Feb1218-3119186156
Partially coherent illumination in full-field interferometric synthetic aperture microscopy.Marks, Daniel L; Davis, Brynmor J; Boppart, Stephen A; Scott Carney, PJournal of the Optical Society of America. A, Optics, image science, and vision2009 Feb376-8619183692
Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.Tang, Hao; Wang, Xiang S; Huang, Xi-Ping; Roth, Bryan L; Butler, Kyle V; Kozikowski, Alan P; Jung, Mira; Tropsha, AlexanderJournal of chemical information and modeling2009 Feb461-7619182860
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.Kao, Shih-Chu; Wu, Hai; Xie, Jianming; Chang, Ching-Pin; Ranish, Jeffrey A; Graef, Isabella A; Crabtree, Gerald RScience (New York, N.Y.)2009 Jan 30651-419179536
Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.Lee, Li Ling; Ha, HyungHo; Chang, Young-Tae; DeLisa, Matthew PProtein science : a publication of the Protein Society2009 Feb277-8619177561
One-pot high-throughput synthesis of beta-turn cyclic peptidomimetics via "volatilizable" supports.Li, Yangmei; Yu, Yongping; Giulianotti, Marc; Houghten, Richard AThe Journal of organic chemistry2009 Mar 62183-519173629
A lipid binding domain in sphingosine kinase 2.Don, Anthony S; Rosen, HughBiochemical and biophysical research communications2009 Feb 2787-9219168031
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Cahill, Catherine M; Lahiri, Debomoy K; Huang, Xudong; Rogers, Jack TBiochimica et biophysica acta2009 Jul615-2819166904
Electron microscopy of whole cells in liquid with nanometer Jonge, N; Peckys, D B; Kremers, G J; Piston, D WProceedings of the National Academy of Sciences of the United States of America2009 Feb 172159-6419164524
An agent-based stochastic tumor model for predicting mitotic arrest drug response.Fox, Brandon M; Moffitt, Richard A; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20085458-6119163952
PASuite: a preprocessing algorithm suite for cellular and molecular image classification in cancer diagnosis and treatment.Sharma, Yachna; Raza, S Hussain; Kong, Koon Y; Chaudry, Qaiser; Muller, Susan; Young, Andrew N; Chen, Zhuo Georgia; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20083114-719163366
Simple quantification of multiplexed quantum dot staining in clinical tissue samples.Caldwell, Matthew L; Moffitt, Richard A; Liu, Jian; Parry, R Mitchell; Sharma, Yachna; Wang, May DConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference20081907-1019163062
Rapid, general access to chiral beta-fluoroamines and beta,beta-difluoroamines via organocatalysis.Fadeyi, Olugbeminiyi O; Lindsley, Craig WOrganic letters2009 Feb 19943-619159275
The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation.Ostrovsky, Olga; Ahmed, Noreen T; Argon, YairMolecular biology of the cell2009 Mar1855-6419158397
Multiplexed plasmonic sensing based on small-dimension nanohole arrays and intensity interrogation.Yang, Jiun-Chan; Ji, Jin; Hogle, James M; Larson, Dale NBiosensors & bioelectronics2009 Apr 152334-819157848
Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.El-Badri, M H; Kurth, Mark JJournal of combinatorial chemistry2009 Mar 9228-3819154120
Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering.Liu, Xiaohua; Smith, Laura A; Hu, Jiang; Ma, Peter XBiomaterials2009 Apr2252-819152974
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.Sommers, Joshua A; Rawtani, Nina; Gupta, Rigu; Bugreev, Dmitry V; Mazin, Alexander V; Cantor, Sharon B; Brosh Jr, Robert MThe Journal of biological chemistry2009 Mar 207505-1719150983
A ratiometric pH reporter for imaging protein-dye conjugates in living cells.Han, Junyan; Loudet, Aurore; Barhoumi, Rola; Burghardt, Robert C; Burgess, KevinJournal of the American Chemical Society2009 Feb 111642-319146412
Parallel synthesis of a library of symmetrically- and dissymmetrically-disubstituted imidazole-4,5-dicarboxamides bearing amino acid esters.Solinas, Rosanna; DiCesare, John C; Baures, Paul WMolecules (Basel, Switzerland)</