1 00:00:00,060 --> 00:00:14,429 do you want to edit and entertain but oh 2 00:00:04,040 --> 00:00:16,949 yeah hello everybody some quick 3 00:00:14,429 --> 00:00:19,439 housekeeping or the question we're going 4 00:00:16,949 --> 00:00:21,359 to host a presentation by Vivian with 5 00:00:19,439 --> 00:00:25,140 some slides that we will post later on 6 00:00:21,359 --> 00:00:26,689 our website the brief presentation we 7 00:00:25,140 --> 00:00:29,340 will have a good long 8 00:00:26,689 --> 00:00:31,170 question-and-answer session we ask that 9 00:00:29,340 --> 00:00:33,690 you post your questions in the chat box 10 00:00:31,170 --> 00:00:37,469 so that we can capture them to post fa 11 00:00:33,690 --> 00:00:39,690 Q's later today or spoon in the 12 00:00:37,469 --> 00:00:41,579 following week so please questions in 13 00:00:39,690 --> 00:00:47,640 the chat box we're going to keep you 14 00:00:41,579 --> 00:00:50,129 muted for now okie retro okay just to 15 00:00:47,640 --> 00:00:51,690 remind everyone thank you for the ones 16 00:00:50,129 --> 00:00:53,520 that folks of you that have already sent 17 00:00:51,690 --> 00:00:57,420 us a whole lot of questions we're 18 00:00:53,520 --> 00:00:59,609 compiling those already and since time 19 00:00:57,420 --> 00:01:01,320 is short we will finance today but 20 00:00:59,609 --> 00:01:04,530 certainly have those addressed in the 21 00:01:01,320 --> 00:01:05,549 coming day really FAQ but right so now 22 00:01:04,530 --> 00:01:07,200 I'm going to do just two short 23 00:01:05,549 --> 00:01:10,439 ten-minute presentation which is going 24 00:01:07,200 --> 00:01:12,900 to give an overview of the OTE the 25 00:01:10,439 --> 00:01:14,729 reasoning behind this there's some 26 00:01:12,900 --> 00:01:17,220 expectations from NIH most of those I 27 00:01:14,729 --> 00:01:19,140 should cover well you read elicitation 28 00:01:17,220 --> 00:01:20,700 it's really just to give you an overview 29 00:01:19,140 --> 00:01:22,080 to that I'm assuming the majority that 30 00:01:20,700 --> 00:01:25,590 people here have already interested in 31 00:01:22,080 --> 00:01:27,030 this and the Robotics Club right so I'm 32 00:01:25,590 --> 00:01:28,729 going to move to the next slide which 33 00:01:27,030 --> 00:01:31,909 types it up 34 00:01:28,729 --> 00:01:31,909 it's right 35 00:01:36,110 --> 00:01:43,580 so the tuning is just that okay I'll get 36 00:01:39,980 --> 00:01:45,560 you DD alright just particularly look at 37 00:01:43,580 --> 00:01:48,530 especially where this program is 38 00:01:45,560 --> 00:01:51,530 situated this program is at NIH and part 39 00:01:48,530 --> 00:01:52,970 of the Common Fund or greater some of 40 00:01:51,530 --> 00:01:55,670 you have dealt with Common Fund some of 41 00:01:52,970 --> 00:01:57,620 you are not actually Common Fund is part 42 00:01:55,670 --> 00:01:59,930 of the Office of the Director or OD and 43 00:01:57,620 --> 00:02:02,450 the Common Fund wrestle is very large 44 00:01:59,930 --> 00:02:04,460 challenging obstacle research and the 45 00:02:02,450 --> 00:02:06,830 idea to capitalize on these kind of new 46 00:02:04,460 --> 00:02:08,570 scientific emerging opportunities for 47 00:02:06,830 --> 00:02:10,640 those of you thin Common Fund programs 48 00:02:08,570 --> 00:02:13,550 are quite diverse and they're quite 49 00:02:10,640 --> 00:02:15,530 large in the common the Commons that 50 00:02:13,550 --> 00:02:18,440 data Commons itself has the fortune of 51 00:02:15,530 --> 00:02:20,300 having a very similar name the other 52 00:02:18,440 --> 00:02:21,800 thing about the Common Fund is they're 53 00:02:20,300 --> 00:02:23,840 looking for very large catalytic 54 00:02:21,800 --> 00:02:26,180 programs really have high impact goals 55 00:02:23,840 --> 00:02:28,040 and a cutting edge science in the order 56 00:02:26,180 --> 00:02:29,870 of five to ten years so they're longer 57 00:02:28,040 --> 00:02:31,910 than some of the other programs we've 58 00:02:29,870 --> 00:02:34,040 seen at NIH they're very goal-driven 59 00:02:31,910 --> 00:02:36,080 Sall though there's research there is 60 00:02:34,040 --> 00:02:38,000 also very much a goal in terms of what 61 00:02:36,080 --> 00:02:40,100 our campuses sort of we want to get for 62 00:02:38,000 --> 00:02:42,140 this particular program again 63 00:02:40,100 --> 00:02:44,090 referencing back to the OT the intent 64 00:02:42,140 --> 00:02:46,310 there is to have a series of capability 65 00:02:44,090 --> 00:02:48,560 where we can really show some defined 66 00:02:46,310 --> 00:02:52,160 use of these data sets in new 67 00:02:48,560 --> 00:02:53,989 computational environments another thing 68 00:02:52,160 --> 00:02:55,910 here is we looking at promoting the 69 00:02:53,989 --> 00:02:59,600 mission of multiple NIH institutes and 70 00:02:55,910 --> 00:03:01,220 there are multiple adaptogen here we're 71 00:02:59,600 --> 00:03:03,290 working directly with the three data 72 00:03:01,220 --> 00:03:05,630 sets that have been discussed in the OT 73 00:03:03,290 --> 00:03:08,959 but are made with common fund but also 74 00:03:05,630 --> 00:03:12,050 NHGRI and also NHLBI and the awards 75 00:03:08,959 --> 00:03:23,750 ought to be through NHLBI so there are 76 00:03:12,050 --> 00:03:25,910 examples of just trial itself that 77 00:03:23,750 --> 00:03:30,890 teaching sound so again please because 78 00:03:25,910 --> 00:03:32,480 you are not taught but right go back to 79 00:03:30,890 --> 00:03:34,820 the purpose of Common Fund it's really 80 00:03:32,480 --> 00:03:37,340 looking at trans-nih programs that a 81 00:03:34,820 --> 00:03:39,080 large and impactful across NIH and 82 00:03:37,340 --> 00:03:41,360 they're cross-cutting requires a high 83 00:03:39,080 --> 00:03:43,519 level of coordination we're very subtle 84 00:03:41,360 --> 00:03:45,980 isn't quite current might be based 85 00:03:43,519 --> 00:03:47,510 programs and we work on all of the folks 86 00:03:45,980 --> 00:03:49,370 that are here with me at the moment 87 00:03:47,510 --> 00:03:50,780 Trinitarian faculty from 88 00:03:49,370 --> 00:03:56,360 have also been contributing to this 89 00:03:50,780 --> 00:04:01,970 program that is far all right let's go 90 00:03:56,360 --> 00:04:04,580 to the next slide so that's of the DOE 91 00:04:01,970 --> 00:04:06,019 Commons as a pilot phase overview many 92 00:04:04,580 --> 00:04:07,909 of you would have signed the big data to 93 00:04:06,019 --> 00:04:09,860 knowledge program and essentially the 94 00:04:07,909 --> 00:04:12,200 Commons or the data Commons is coming at 95 00:04:09,860 --> 00:04:13,790 the second phase of this program we're 96 00:04:12,200 --> 00:04:16,400 going to be looking at essentially look 97 00:04:13,790 --> 00:04:19,010 providing a collection of nih-funded 98 00:04:16,400 --> 00:04:23,780 datasets and making them available in 99 00:04:19,010 --> 00:04:25,940 public clouds with associated tools in 100 00:04:23,780 --> 00:04:29,210 particular we're looking at using a test 101 00:04:25,940 --> 00:04:31,699 phase here for particular data sets and 102 00:04:29,210 --> 00:04:33,800 we'll speak more about that probably 103 00:04:31,699 --> 00:04:35,389 later those three data sets are chosen 104 00:04:33,800 --> 00:04:37,130 just as a starting point which is why 105 00:04:35,389 --> 00:04:39,289 this is the pilot phase those data set 106 00:04:37,130 --> 00:04:40,910 the top mid GTX 10 mods and they are 107 00:04:39,289 --> 00:04:42,169 test cases for the principles and 108 00:04:40,910 --> 00:04:44,300 policies that we'll be using in this 109 00:04:42,169 --> 00:04:48,050 particular program and also to develop 110 00:04:44,300 --> 00:04:51,020 the architectures we expect to see the 111 00:04:48,050 --> 00:04:53,240 overall goal here is we realizing that 112 00:04:51,020 --> 00:04:55,400 NIH we have incredibly large data sets 113 00:04:53,240 --> 00:04:57,620 and incredibly valuable data sets that 114 00:04:55,400 --> 00:04:58,910 people want to consume and we're finding 115 00:04:57,620 --> 00:05:01,070 that many people are wanting to use 116 00:04:58,910 --> 00:05:02,930 public clouds to the L objective and 117 00:05:01,070 --> 00:05:05,690 we're looking for methods to ensure that 118 00:05:02,930 --> 00:05:07,400 the datasets are highly usable by all 119 00:05:05,690 --> 00:05:09,349 the research community in a way that 120 00:05:07,400 --> 00:05:11,660 they these datasets can be stored shared 121 00:05:09,349 --> 00:05:13,220 access and computed on in the right 122 00:05:11,660 --> 00:05:14,510 environment for people to be able to do 123 00:05:13,220 --> 00:05:16,190 this work and I think there's a lot of 124 00:05:14,510 --> 00:05:18,260 background information that has happened 125 00:05:16,190 --> 00:05:19,760 over the last two years which has shown 126 00:05:18,260 --> 00:05:21,199 people are moving to the cloud in a 127 00:05:19,760 --> 00:05:23,360 variety of different forms what we 128 00:05:21,199 --> 00:05:24,919 trying to do is for that step to figure 129 00:05:23,360 --> 00:05:26,960 out what's the right way to have this 130 00:05:24,919 --> 00:05:28,539 data available most systems what the 131 00:05:26,960 --> 00:05:30,710 architecture is supported and 132 00:05:28,539 --> 00:05:31,430 importantly how do we do this give it a 133 00:05:30,710 --> 00:05:34,280 back 134 00:05:31,430 --> 00:05:36,320 subject data that has elicits all the 135 00:05:34,280 --> 00:05:38,240 issues with human subjects concerns the 136 00:05:36,320 --> 00:05:39,740 Elsi issues associated with that and 137 00:05:38,240 --> 00:05:41,419 we're very concerned about those issues 138 00:05:39,740 --> 00:05:42,770 so we're being very careful about that 139 00:05:41,419 --> 00:05:46,789 and that's why they're being discussed 140 00:05:42,770 --> 00:05:48,919 or shown SOT all right the project is 141 00:05:46,789 --> 00:05:52,210 going to go for a period of four years 142 00:05:48,919 --> 00:05:56,259 and the budget is a properly 143 00:05:52,210 --> 00:06:02,840 [Music] 144 00:05:56,259 --> 00:06:04,310 how do I get 25 got it perfect all right 145 00:06:02,840 --> 00:06:06,379 let's have a look just I'm going to 146 00:06:04,310 --> 00:06:09,770 briefly just go what's already in the OT 147 00:06:06,379 --> 00:06:11,479 there are eight key technical scientific 148 00:06:09,770 --> 00:06:12,770 computing capabilities which I'm not 149 00:06:11,479 --> 00:06:14,990 going to go through here in detail 150 00:06:12,770 --> 00:06:18,050 you've all had a chance to look at those 151 00:06:14,990 --> 00:06:19,879 and we're also looking at a set of some 152 00:06:18,050 --> 00:06:22,250 minimum standards which really relate to 153 00:06:19,879 --> 00:06:24,229 openness portability probability of 154 00:06:22,250 --> 00:06:27,259 whatever is going to be developed those 155 00:06:24,229 --> 00:06:30,800 are also described in the OT and we're 156 00:06:27,259 --> 00:06:32,960 encouraging applicants to have a very 157 00:06:30,800 --> 00:06:36,949 innovative approaches to the way that 158 00:06:32,960 --> 00:06:39,979 you do this and we also would like us to 159 00:06:36,949 --> 00:06:42,050 eat dress not necessarily one capability 160 00:06:39,979 --> 00:06:43,819 you could address one more or any of 161 00:06:42,050 --> 00:06:45,319 those capabilities that has been a 162 00:06:43,819 --> 00:06:47,000 question that has come up a number of 163 00:06:45,319 --> 00:06:49,819 times can we address more than one 164 00:06:47,000 --> 00:06:52,669 capability yes is up to you to decide 165 00:06:49,819 --> 00:06:54,500 how you want to do that what I'm also 166 00:06:52,669 --> 00:06:56,930 saying here is for those key 167 00:06:54,500 --> 00:06:58,909 capabilities when you do that you must 168 00:06:56,930 --> 00:07:02,479 be able to justify why you'd be doing 169 00:06:58,909 --> 00:07:03,919 one or more or collection of those we're 170 00:07:02,479 --> 00:07:05,810 also happy to have additional 171 00:07:03,919 --> 00:07:07,550 capabilities suggested but we really 172 00:07:05,810 --> 00:07:10,669 want you to be able to clearly justify 173 00:07:07,550 --> 00:07:13,279 and describe those and if you have a new 174 00:07:10,669 --> 00:07:15,440 additional capacity and you want to have 175 00:07:13,279 --> 00:07:17,710 it connected to one of the other ones 176 00:07:15,440 --> 00:07:20,569 that we described that is also fine but 177 00:07:17,710 --> 00:07:22,690 you again have to justify it extremely 178 00:07:20,569 --> 00:07:22,690 well 179 00:07:28,820 --> 00:07:34,169 all right so in terms of the OT let's 180 00:07:32,610 --> 00:07:36,419 have a look at those pieces so what I 181 00:07:34,169 --> 00:07:38,669 just covered now with those the 8 182 00:07:36,419 --> 00:07:41,370 capabilities and some of the others that 183 00:07:38,669 --> 00:07:43,500 we have and the fact that we are able to 184 00:07:41,370 --> 00:07:45,060 mix and match you can apply to either 185 00:07:43,500 --> 00:07:46,860 one or multiple ones and you can come in 186 00:07:45,060 --> 00:07:49,020 as groups to look at that or not it is 187 00:07:46,860 --> 00:07:51,030 up to you we are encouraging the 188 00:07:49,020 --> 00:07:52,860 community to actually have input and how 189 00:07:51,030 --> 00:07:54,810 you want to organize around doing this 190 00:07:52,860 --> 00:07:57,479 we would like to see those innovative 191 00:07:54,810 --> 00:07:58,800 approaches from the community talk a 192 00:07:57,479 --> 00:08:01,740 little bit more about the process here 193 00:07:58,800 --> 00:08:05,220 since it is new to many folks which is 194 00:08:01,740 --> 00:08:07,860 it's an other transaction it's an OT so 195 00:08:05,220 --> 00:08:10,020 we're going to do is have two stages we 196 00:08:07,860 --> 00:08:12,180 expect to have an award which is an OT 197 00:08:10,020 --> 00:08:13,740 the other a transaction award to support 198 00:08:12,180 --> 00:08:15,060 a number of different projects that we 199 00:08:13,740 --> 00:08:17,729 think will be responsive to the 200 00:08:15,060 --> 00:08:19,110 solicitation and are considered as I was 201 00:08:17,729 --> 00:08:21,870 saying before high attack cutting edge 202 00:08:19,110 --> 00:08:24,510 know and have really good ideas that we 203 00:08:21,870 --> 00:08:26,160 can actually implement we also expect 204 00:08:24,510 --> 00:08:27,840 the wood is to form a consortium which 205 00:08:26,160 --> 00:08:30,630 we call the data Commons pilot phase 206 00:08:27,840 --> 00:08:33,330 consortium DCP PC which is noted many 207 00:08:30,630 --> 00:08:35,190 times in the solicitations and we will 208 00:08:33,330 --> 00:08:37,140 also expect the awardees out of this 209 00:08:35,190 --> 00:08:39,300 patient to be working with the 210 00:08:37,140 --> 00:08:41,370 investigators that are funded to do the 211 00:08:39,300 --> 00:08:43,860 data sets with top net mods energy text 212 00:08:41,370 --> 00:08:45,690 and it will be a collection of those 213 00:08:43,860 --> 00:08:48,990 folks so those awarded from this 214 00:08:45,690 --> 00:08:57,209 solicitation and those investigators 215 00:08:48,990 --> 00:09:00,650 come over on top he texts you please 216 00:08:57,209 --> 00:09:03,450 mute your phones if you are not talking 217 00:09:00,650 --> 00:09:05,850 so stage one is essentially to form a 218 00:09:03,450 --> 00:09:08,630 consortium of a collection of folks that 219 00:09:05,850 --> 00:09:11,670 would be put at this solicitation 220 00:09:08,630 --> 00:09:13,440 including the investigate med pod and 221 00:09:11,670 --> 00:09:14,880 gtex and I know I'm repeating myself but 222 00:09:13,440 --> 00:09:16,410 I want to make it clear I had multiple 223 00:09:14,880 --> 00:09:18,600 questions asking me this multiple times 224 00:09:16,410 --> 00:09:19,980 though I'm just wanting to make it clear 225 00:09:18,600 --> 00:09:23,040 we're looking at these three data sets 226 00:09:19,980 --> 00:09:25,020 to start with so in the first stage we 227 00:09:23,040 --> 00:09:28,529 expect this consortium to form together 228 00:09:25,020 --> 00:09:32,070 and working together for up to 180 days 229 00:09:28,529 --> 00:09:33,720 and our goal out of that is to come up 230 00:09:32,070 --> 00:09:35,459 with series of prototypes and also a 231 00:09:33,720 --> 00:09:37,320 plan of what would make sense going 232 00:09:35,459 --> 00:09:38,700 forward we're aware of some of the 233 00:09:37,320 --> 00:09:40,079 components that we need for this 234 00:09:38,700 --> 00:09:41,970 particular work that we're also aware 235 00:09:40,079 --> 00:09:42,490 that we need to do some investigations 236 00:09:41,970 --> 00:09:45,120 get a better 237 00:09:42,490 --> 00:09:48,250 understanding what's actually needed 238 00:09:45,120 --> 00:09:50,500 once that first stage is completed we 239 00:09:48,250 --> 00:09:53,290 expect stage 2 to be an evaluation and 240 00:09:50,500 --> 00:09:56,350 we negotiate revised terms of code 241 00:09:53,290 --> 00:09:58,930 Awards we maybe look at it we may want 242 00:09:56,350 --> 00:10:00,910 to add things those plans will inform us 243 00:09:58,930 --> 00:10:02,500 about what we do next so stage 1 is 244 00:10:00,910 --> 00:10:03,820 essentially the planning and prototyping 245 00:10:02,500 --> 00:10:10,240 and stage 2 would be the long-term 246 00:10:03,820 --> 00:10:12,850 implementation of canvas all right let's 247 00:10:10,240 --> 00:10:14,230 get to small practical aspects of the OT 248 00:10:12,850 --> 00:10:17,200 because again we've had multiple 249 00:10:14,230 --> 00:10:19,930 questions the letter of intent is 250 00:10:17,200 --> 00:10:21,550 required and is mandated for this and it 251 00:10:19,930 --> 00:10:22,899 is due on June 30th there are no 252 00:10:21,550 --> 00:10:24,610 extensions to this there have been a 253 00:10:22,899 --> 00:10:26,860 number of questions about this this will 254 00:10:24,610 --> 00:10:28,680 be the date June 30th 5:00 p.m. United 255 00:10:26,860 --> 00:10:31,120 States Eastern Standard Time 256 00:10:28,680 --> 00:10:32,770 LOIs will be reviewed but for the 257 00:10:31,120 --> 00:10:36,399 programmatic relevance this will be done 258 00:10:32,770 --> 00:10:38,050 by July 7th 2017 and then based on that 259 00:10:36,399 --> 00:10:40,360 a selector groups will be invited to 260 00:10:38,050 --> 00:10:43,839 submit an application on or around July 261 00:10:40,360 --> 00:10:45,760 12 and only those that have been invited 262 00:10:43,839 --> 00:10:48,399 can apply for the actual full 263 00:10:45,760 --> 00:10:50,050 application so do not put in your 264 00:10:48,399 --> 00:10:53,430 application if you've not been invited 265 00:10:50,050 --> 00:10:57,279 the final applications are due July 31 266 00:10:53,430 --> 00:10:59,680 2017 if not been invited do not put in 267 00:10:57,279 --> 00:11:02,770 application if you do it will not be 268 00:10:59,680 --> 00:11:05,529 reviewed mandatory kickoff will be on 269 00:11:02,770 --> 00:11:08,730 October 5 and this is a kickoff meeting 270 00:11:05,529 --> 00:11:15,040 for the that data can sort of get better 271 00:11:08,730 --> 00:11:19,899 the data Commons acknowledge please mute 272 00:11:15,040 --> 00:11:21,250 your phone thank you all right let's 273 00:11:19,899 --> 00:11:22,570 look a little bit more in the details of 274 00:11:21,250 --> 00:11:24,190 the letter and intent I'll go through 275 00:11:22,570 --> 00:11:25,180 this relatively quickly but I'm just 276 00:11:24,190 --> 00:11:27,399 putting it up there because there's been 277 00:11:25,180 --> 00:11:29,190 a lot of questions which really I 278 00:11:27,399 --> 00:11:31,810 answered by reading the solicitation 279 00:11:29,190 --> 00:11:33,490 we're asking that you have a letter of 280 00:11:31,810 --> 00:11:35,410 intent as I mentioned before it is 281 00:11:33,490 --> 00:11:37,240 required you cannot get to the next step 282 00:11:35,410 --> 00:11:39,010 without it if you do not put a letter of 283 00:11:37,240 --> 00:11:41,380 intent in you will not be able to put an 284 00:11:39,010 --> 00:11:43,240 application in at all these are the 285 00:11:41,380 --> 00:11:44,620 kinds of descriptives pieces that we 286 00:11:43,240 --> 00:11:46,270 want you to have in your letter of 287 00:11:44,620 --> 00:11:47,890 intent obviously the number and title 288 00:11:46,270 --> 00:11:50,200 the research opportunity descriptive 289 00:11:47,890 --> 00:11:52,660 title and for each of the capabilities 290 00:11:50,200 --> 00:11:54,160 these various aspects I'm not going to 291 00:11:52,660 --> 00:11:57,000 go through these in a lot of detail I'm 292 00:11:54,160 --> 00:11:57,000 just putting those it 293 00:11:57,550 --> 00:12:02,529 they're taken directly from the OT 294 00:12:00,730 --> 00:12:04,089 solicitation I'm just drawing your 295 00:12:02,529 --> 00:12:07,170 attention to them to ensure that you 296 00:12:04,089 --> 00:12:09,850 actually comply with the request here 297 00:12:07,170 --> 00:12:12,220 again if you have any questions to this 298 00:12:09,850 --> 00:12:14,319 and also once you complete your LOI 299 00:12:12,220 --> 00:12:18,189 ensure that you mail it to this address 300 00:12:14,319 --> 00:12:19,569 common pilot at ovh gov there are a lot 301 00:12:18,189 --> 00:12:21,189 of folks out there in the community who 302 00:12:19,569 --> 00:12:22,779 know me and as much as I appreciate your 303 00:12:21,189 --> 00:12:25,299 emails we really need these to be 304 00:12:22,779 --> 00:12:27,160 compiled onto this particular mailbox so 305 00:12:25,299 --> 00:12:29,619 please send your mail to this particular 306 00:12:27,160 --> 00:12:31,239 mail but there are a lot of emails 307 00:12:29,619 --> 00:12:32,920 coming in and a lot of inquiries and 308 00:12:31,239 --> 00:12:35,110 there is a team which is looking at this 309 00:12:32,920 --> 00:12:37,689 mailbox not just me so in order to be 310 00:12:35,110 --> 00:12:39,309 have a rapid turnaround I'm sure that 311 00:12:37,689 --> 00:12:43,089 you will send your mail to this 312 00:12:39,309 --> 00:12:45,429 particular mailbox right the full 313 00:12:43,089 --> 00:12:48,069 application and I'll get to this a 314 00:12:45,429 --> 00:12:49,540 little bit in when we talk about the OT 315 00:12:48,069 --> 00:12:52,629 a little bit more this is a different 316 00:12:49,540 --> 00:12:55,389 kind of animal to grant in a contract so 317 00:12:52,629 --> 00:12:57,339 as stated here it's not a typical NIH 318 00:12:55,389 --> 00:12:59,410 grant here is an outline of what we 319 00:12:57,339 --> 00:13:02,980 expect in the full application again 320 00:12:59,410 --> 00:13:04,769 comes out of the solicitation but we're 321 00:13:02,980 --> 00:13:06,549 looking for short but clear 322 00:13:04,769 --> 00:13:09,639 identification of how you're going to 323 00:13:06,549 --> 00:13:11,259 address those key capabilities what's 324 00:13:09,639 --> 00:13:12,459 your intent there why do you think 325 00:13:11,259 --> 00:13:14,139 you're going to do what you're doing and 326 00:13:12,459 --> 00:13:15,970 how are you going to support that both 327 00:13:14,139 --> 00:13:18,220 in terms of the science and technology 328 00:13:15,970 --> 00:13:19,899 you're doing and the people that would 329 00:13:18,220 --> 00:13:23,170 be there that would be supporting those 330 00:13:19,899 --> 00:13:25,959 particular capital some form of statute 331 00:13:23,170 --> 00:13:27,610 require of your justification we're not 332 00:13:25,959 --> 00:13:32,470 setting limits on this we'd like to see 333 00:13:27,610 --> 00:13:34,179 what people are willing so I I think 334 00:13:32,470 --> 00:13:40,389 being a realistic budget is what my 335 00:13:34,179 --> 00:13:42,549 recommendation would be evaluation there 336 00:13:40,389 --> 00:13:44,559 will be an objective review phase for 337 00:13:42,549 --> 00:13:46,240 both parts there will be obviously one 338 00:13:44,559 --> 00:13:48,549 for the letter of intent and it's based 339 00:13:46,240 --> 00:13:50,980 on the team members your key personnel 340 00:13:48,549 --> 00:13:52,600 the past the photos our activities and 341 00:13:50,980 --> 00:13:55,239 the adequacy appropriately double 342 00:13:52,600 --> 00:13:58,629 resources-we your phone if are not 343 00:13:55,239 --> 00:14:01,360 talking and that's me at the moment but 344 00:13:58,629 --> 00:14:04,269 the application which will be obviously 345 00:14:01,360 --> 00:14:05,919 longer has a slightly broader requests 346 00:14:04,269 --> 00:14:08,379 and you're looking at the vision 347 00:14:05,919 --> 00:14:09,600 statement for what you're doing from a 348 00:14:08,379 --> 00:14:11,130 plant in 349 00:14:09,600 --> 00:14:13,470 specifics around the relevant components 350 00:14:11,130 --> 00:14:15,480 and those key capabilities also how you 351 00:14:13,470 --> 00:14:17,699 plan to engage with the community Brett 352 00:14:15,480 --> 00:14:19,649 and and how you would demonstrate the 353 00:14:17,699 --> 00:14:22,110 value of this particular project 354 00:14:19,649 --> 00:14:23,730 I think it's important to show you a 355 00:14:22,110 --> 00:14:25,620 past performance and the expertise of 356 00:14:23,730 --> 00:14:27,779 your team members we want to see that 357 00:14:25,620 --> 00:14:30,240 you have ability in this area again the 358 00:14:27,779 --> 00:14:32,550 only not entered contract or grant is 359 00:14:30,240 --> 00:14:34,470 looking at implementation parts for some 360 00:14:32,550 --> 00:14:35,790 of these things are not looking so much 361 00:14:34,470 --> 00:14:37,560 for the research we're looking for the 362 00:14:35,790 --> 00:14:40,470 R&D and then the production of some of 363 00:14:37,560 --> 00:14:42,240 this again relation to the budget we're 364 00:14:40,470 --> 00:14:44,009 not defining the actual budget we're 365 00:14:42,240 --> 00:14:44,910 asking you to provide it but it has to 366 00:14:44,009 --> 00:14:50,639 be appropriate for what you're 367 00:14:44,910 --> 00:14:52,500 requesting other considerations just a 368 00:14:50,639 --> 00:14:55,920 few comments around the budget it's 21 369 00:14:52,500 --> 00:14:57,630 over a four-year period however because 370 00:14:55,920 --> 00:14:59,519 of the way the OTS is structured there's 371 00:14:57,630 --> 00:15:01,920 significant flexibility and ability to 372 00:14:59,519 --> 00:15:03,720 handle OTS and the adjustments will be 373 00:15:01,920 --> 00:15:05,009 Bay based on sure of the work they're 374 00:15:03,720 --> 00:15:07,380 actually doing and what we're actually 375 00:15:05,009 --> 00:15:09,660 finding this gives us a lot more 376 00:15:07,380 --> 00:15:12,690 flexibility to be able to get to an end 377 00:15:09,660 --> 00:15:13,769 point and have milestones achieved and 378 00:15:12,690 --> 00:15:15,779 that's part of the reason we want to be 379 00:15:13,769 --> 00:15:17,220 flexible here period performance is 380 00:15:15,779 --> 00:15:19,050 between three and four years again 381 00:15:17,220 --> 00:15:25,220 somewhat flexible it depends on the 382 00:15:19,050 --> 00:15:28,769 outcome of these particular awards and 383 00:15:25,220 --> 00:15:32,819 advice so there's one more slide that I 384 00:15:28,769 --> 00:15:39,630 think was missing here can we go back it 385 00:15:32,819 --> 00:15:41,009 got skipped this one number four yes I 386 00:15:39,630 --> 00:15:47,130 don't know why I didn't show up but it 387 00:15:41,009 --> 00:15:49,380 didn't did it okay so I just want to 388 00:15:47,130 --> 00:15:51,449 raise this slide which my apologies it 389 00:15:49,380 --> 00:15:54,089 got somehow skipped in the process I 390 00:15:51,449 --> 00:15:55,800 want to highlight the issue about other 391 00:15:54,089 --> 00:15:57,930 transactions as I've mentioned before 392 00:15:55,800 --> 00:15:59,699 it's a unique funding mechanism it's not 393 00:15:57,930 --> 00:16:01,709 a grant or cooperative agreement or a 394 00:15:59,699 --> 00:16:04,050 contract and why are we doing this 395 00:16:01,709 --> 00:16:05,730 because this kind of project requires it 396 00:16:04,050 --> 00:16:07,310 to be far more flexible and we want to 397 00:16:05,730 --> 00:16:11,430 work with different kinds of partners 398 00:16:07,310 --> 00:16:13,860 that means academics researchers and 399 00:16:11,430 --> 00:16:15,630 commercial entities and I just want to 400 00:16:13,860 --> 00:16:17,459 say that very clearly again that means 401 00:16:15,630 --> 00:16:18,720 academics researchers and commercial 402 00:16:17,459 --> 00:16:20,250 entities have been a number of questions 403 00:16:18,720 --> 00:16:22,050 that have come in saying can i partner 404 00:16:20,250 --> 00:16:22,950 with a commercial entity the answer is 405 00:16:22,050 --> 00:16:25,380 yes 406 00:16:22,950 --> 00:16:26,910 we also might expect that commercial 407 00:16:25,380 --> 00:16:31,950 entities on their own would apply for 408 00:16:26,910 --> 00:16:33,570 this that is also okay so in terms of 409 00:16:31,950 --> 00:16:35,370 the OT we have a publication on the 410 00:16:33,570 --> 00:16:37,740 website which all of you have now seen I 411 00:16:35,370 --> 00:16:39,330 presume and as I just mentioned now it 412 00:16:37,740 --> 00:16:41,310 encourages non-traditional partners 413 00:16:39,330 --> 00:16:43,440 again because of the nature what we're 414 00:16:41,310 --> 00:16:45,720 trying to do which is strongly 415 00:16:43,440 --> 00:16:49,170 technology-based to support biomedical 416 00:16:45,720 --> 00:16:50,400 research NIH just has some track record 417 00:16:49,170 --> 00:16:51,870 in dealing with technologies and 418 00:16:50,400 --> 00:16:53,790 computational areas but it's still 419 00:16:51,870 --> 00:16:55,590 obviously very focused on the bio side 420 00:16:53,790 --> 00:16:57,150 of things so in this case we're 421 00:16:55,590 --> 00:16:58,770 realizing that some of our partnerships 422 00:16:57,150 --> 00:17:00,660 are going to have to happen with those 423 00:16:58,770 --> 00:17:02,280 folks in different technology areas that 424 00:17:00,660 --> 00:17:04,949 don't traditionally apply for grants or 425 00:17:02,280 --> 00:17:06,660 work with NIH creating those kind of 426 00:17:04,949 --> 00:17:08,250 partnerships and the Krait relationships 427 00:17:06,660 --> 00:17:11,490 is really paramount and the ability for 428 00:17:08,250 --> 00:17:13,470 this particular solicitation to be 429 00:17:11,490 --> 00:17:16,680 effective so that is the reason why 430 00:17:13,470 --> 00:17:18,180 we're using this ot mechanism in terms 431 00:17:16,680 --> 00:17:20,670 of the evaluation I talked about this a 432 00:17:18,180 --> 00:17:22,110 little bit before but we'll have the 433 00:17:20,670 --> 00:17:23,850 objective review criteria which I've 434 00:17:22,110 --> 00:17:25,800 discussed in these slides they are also 435 00:17:23,850 --> 00:17:27,780 presented in detail in the solicitation 436 00:17:25,800 --> 00:17:29,730 itself there will be interactive 437 00:17:27,780 --> 00:17:31,530 discussions with program staff and also 438 00:17:29,730 --> 00:17:33,630 external experts as needed for the 439 00:17:31,530 --> 00:17:36,530 review and we will also be looking at 440 00:17:33,630 --> 00:17:38,940 selections of which components of these 441 00:17:36,530 --> 00:17:40,650 applications that have come in make the 442 00:17:38,940 --> 00:17:43,950 most sense to achieve the goals that we 443 00:17:40,650 --> 00:17:46,710 have for this particular project as I 444 00:17:43,950 --> 00:17:49,830 mentioned many times now the awards that 445 00:17:46,710 --> 00:17:52,380 he allows us a level of flexibility the 446 00:17:49,830 --> 00:17:54,150 award can be can have several aspects it 447 00:17:52,380 --> 00:17:55,950 can be expanded it can be modified we 448 00:17:54,150 --> 00:17:58,170 can look at different partnerships we 449 00:17:55,950 --> 00:18:00,060 can not support we can discontinue these 450 00:17:58,170 --> 00:18:02,070 are the kinds of things we need to do to 451 00:18:00,060 --> 00:18:04,710 be more agile in the way that we 452 00:18:02,070 --> 00:18:07,350 actually go towards this project 453 00:18:04,710 --> 00:18:08,730 leadership at NIH and by that I mean dr. 454 00:18:07,350 --> 00:18:11,930 Francis Collins who's the director of 455 00:18:08,730 --> 00:18:14,430 NIH is very keen along with some other 456 00:18:11,930 --> 00:18:17,070 Institute directors to develop these 457 00:18:14,430 --> 00:18:19,860 particular areas and engagements in both 458 00:18:17,070 --> 00:18:21,720 technology and in science and we know 459 00:18:19,860 --> 00:18:24,330 that we have to be agile and flexible to 460 00:18:21,720 --> 00:18:25,920 do this we also know that we are looking 461 00:18:24,330 --> 00:18:28,110 at new experiences in partnering with 462 00:18:25,920 --> 00:18:29,550 non-traditional members in the community 463 00:18:28,110 --> 00:18:33,420 particularly in the computing sciences 464 00:18:29,550 --> 00:18:34,920 and mathematics and also able to be 465 00:18:33,420 --> 00:18:36,280 flexible about how we operate in the 466 00:18:34,920 --> 00:18:39,100 environment as we learn from 467 00:18:36,280 --> 00:18:41,110 as well but all of these based on the 468 00:18:39,100 --> 00:18:42,820 fact on obviously program need emerging 469 00:18:41,110 --> 00:18:44,350 needs as we go through the program and 470 00:18:42,820 --> 00:18:46,750 find out what we need to do and we 471 00:18:44,350 --> 00:18:48,400 assess the technology approaches that we 472 00:18:46,750 --> 00:18:49,990 use we realize that some of these will 473 00:18:48,400 --> 00:18:52,750 be brand new to us and we have to assess 474 00:18:49,990 --> 00:18:54,400 whether they help them and obviously the 475 00:18:52,750 --> 00:18:56,920 availability of funds that's based on 476 00:18:54,400 --> 00:18:59,980 the NIH budget budget available to the 477 00:18:56,920 --> 00:19:01,630 Simmons program now what I will do is go 478 00:18:59,980 --> 00:19:02,980 to the very last slide and I apologies 479 00:19:01,630 --> 00:19:04,930 for missing this one but this is an 480 00:19:02,980 --> 00:19:07,690 important one because this talks about 481 00:19:04,930 --> 00:19:09,070 the actual mechanism I'm just going to 482 00:19:07,690 --> 00:19:10,660 reiterate this because I know this will 483 00:19:09,070 --> 00:19:12,160 come up multiple times it's not a grant 484 00:19:10,660 --> 00:19:14,650 it's not a cooperative agreement and 485 00:19:12,160 --> 00:19:16,750 it's not a go track the transaction it's 486 00:19:14,650 --> 00:19:18,040 an OT some of the questions I've had 487 00:19:16,750 --> 00:19:19,420 have come in from folks who are 488 00:19:18,040 --> 00:19:21,640 obviously very used to dealing with 489 00:19:19,420 --> 00:19:23,490 grants cooperative agreements and more 490 00:19:21,640 --> 00:19:26,080 contracts and this is quite different 491 00:19:23,490 --> 00:19:28,330 for a lot of people there are not that 492 00:19:26,080 --> 00:19:31,870 many OTS that are running at NIH 493 00:19:28,330 --> 00:19:33,810 I think the PMI initiative is one and I 494 00:19:31,870 --> 00:19:39,130 think there's in the SPARC initiative 495 00:19:33,810 --> 00:19:41,290 from the Common Fund on and again the 496 00:19:39,130 --> 00:19:42,970 reason for these is again the 497 00:19:41,290 --> 00:19:44,580 flexibility for being able to do this 498 00:19:42,970 --> 00:19:47,470 particularly at cutting-edge scientist 499 00:19:44,580 --> 00:19:49,870 and also to incorporate non-traditional 500 00:19:47,470 --> 00:19:51,430 partners so I just want to finish up 501 00:19:49,870 --> 00:19:53,650 with these two slides that are the 502 00:19:51,430 --> 00:19:55,510 advise you is to read the opportunity 503 00:19:53,650 --> 00:19:57,460 read the opportunity read the 504 00:19:55,510 --> 00:20:00,490 opportunity I would put that in multiple 505 00:19:57,460 --> 00:20:02,500 languages if I can because some of the 506 00:20:00,490 --> 00:20:04,600 questions I received already you either 507 00:20:02,500 --> 00:20:08,290 haven't read it or you need to reread it 508 00:20:04,600 --> 00:20:10,570 seems to be something that I think would 509 00:20:08,290 --> 00:20:12,340 be valid for you to look at the FAQ 510 00:20:10,570 --> 00:20:14,230 which virtual Brett just described 511 00:20:12,340 --> 00:20:15,760 before and is live on our web site will 512 00:20:14,230 --> 00:20:17,620 be updated with the questions that we've 513 00:20:15,760 --> 00:20:20,320 received so far this week and also the 514 00:20:17,620 --> 00:20:22,810 ones we received from this webinar terms 515 00:20:20,320 --> 00:20:25,120 of your actual LOI and if you go to the 516 00:20:22,810 --> 00:20:28,000 stage for application be as specific as 517 00:20:25,120 --> 00:20:30,520 possible be clear about what the asking 518 00:20:28,000 --> 00:20:32,890 for and why you have a very short space 519 00:20:30,520 --> 00:20:34,600 to articulate what it is that you need 520 00:20:32,890 --> 00:20:38,170 to do and we need you to be clear and 521 00:20:34,600 --> 00:20:40,420 specific do not distort reality I have 522 00:20:38,170 --> 00:20:42,130 seen many people claim they can do a lot 523 00:20:40,420 --> 00:20:46,120 a bunch of things but in fact they 524 00:20:42,130 --> 00:20:47,560 cannot so yeah not a good 525 00:20:46,120 --> 00:20:49,240 place for you to be in terms of the way 526 00:20:47,560 --> 00:20:51,850 you write your LOI or your act 527 00:20:49,240 --> 00:20:55,660 ocation be clear be straightforward and 528 00:20:51,850 --> 00:20:57,520 be clear about your actual bill you 529 00:20:55,660 --> 00:21:00,040 don't waste pages do not add a lot of 530 00:20:57,520 --> 00:21:01,780 your user account with the LOI it's 531 00:21:00,040 --> 00:21:04,300 short or the application with extraneous 532 00:21:01,780 --> 00:21:06,760 information yeah look how can you 533 00:21:04,300 --> 00:21:09,130 address how to keep these keeping in 534 00:21:06,760 --> 00:21:11,290 mind those fix standards that we've 535 00:21:09,130 --> 00:21:12,970 articulated and how can you come out 536 00:21:11,290 --> 00:21:14,740 with something that could really be 537 00:21:12,970 --> 00:21:17,230 articulated as a prototype or help us 538 00:21:14,740 --> 00:21:19,540 understand how to develop very concrete 539 00:21:17,230 --> 00:21:21,130 plans within six months if you just have 540 00:21:19,540 --> 00:21:22,990 an idea that you want to take from an 541 00:21:21,130 --> 00:21:25,000 idea and look at it as a research piece 542 00:21:22,990 --> 00:21:28,120 this is not the opportunity that you 543 00:21:25,000 --> 00:21:29,650 want to apply for and justifying justify 544 00:21:28,120 --> 00:21:31,000 everything you're actually doing if you 545 00:21:29,650 --> 00:21:32,740 just simply say you can do it but you 546 00:21:31,000 --> 00:21:32,920 can't actually justify why you're doing 547 00:21:32,740 --> 00:21:34,660 that 548 00:21:32,920 --> 00:21:37,240 that is a concern for us and that 549 00:21:34,660 --> 00:21:39,220 applies to the key capabilities that 550 00:21:37,240 --> 00:21:40,690 you're addressing to the team personnel 551 00:21:39,220 --> 00:21:46,150 to the budget you're actually applying 552 00:21:40,690 --> 00:21:48,160 for roughly the contacts for this 553 00:21:46,150 --> 00:21:50,380 particular solicitation and myself for 554 00:21:48,160 --> 00:21:51,970 the research and science and technology 555 00:21:50,380 --> 00:21:53,680 parts that's me that's Vivian Benassi 556 00:21:51,970 --> 00:21:56,560 I'm from the Office of the Director and 557 00:21:53,680 --> 00:21:59,830 for the financial agreements side and 558 00:21:56,560 --> 00:22:03,070 the contract side who Teresa Marquette 559 00:21:59,830 --> 00:22:04,780 who is here with us and has also had 560 00:22:03,070 --> 00:22:07,480 extensive experience in dealing with OTS 561 00:22:04,780 --> 00:22:09,510 so we're very lucky to have her as I 562 00:22:07,480 --> 00:22:11,770 mentioned earlier in this presentation 563 00:22:09,510 --> 00:22:14,110 make sure LBI will be handling the 564 00:22:11,770 --> 00:22:15,460 awards and be processed at and we're 565 00:22:14,110 --> 00:22:17,560 most grateful to be able to work with 566 00:22:15,460 --> 00:22:20,920 them all right with that that's the 567 00:22:17,560 --> 00:22:25,260 conclusion is what I thought is that I 568 00:22:20,920 --> 00:22:25,260 think we'll open it up for questions and 569 00:22:25,320 --> 00:22:30,190 anyone can ask us some questions or do 570 00:22:27,610 --> 00:22:30,880 we have any from the chat box in our 571 00:22:30,190 --> 00:22:36,790 heart 572 00:22:30,880 --> 00:22:39,460 ah the disabilities water and weigh in 573 00:22:36,790 --> 00:22:45,250 maybe 5,000 per minute 574 00:22:39,460 --> 00:22:47,050 oh look at this yeah it's very difficult 575 00:22:45,250 --> 00:22:48,370 to hear people so what I suggest is put 576 00:22:47,050 --> 00:22:53,740 all your questions through the chat box 577 00:22:48,370 --> 00:23:00,490 please CSS I can read it 578 00:22:53,740 --> 00:23:01,720 yeah so I'm just looking there silence 579 00:23:00,490 --> 00:23:03,870 because I'm just looking through them 580 00:23:01,720 --> 00:23:03,870 now 581 00:23:08,750 --> 00:23:12,020 still looking 582 00:23:12,890 --> 00:23:16,700 alright let's here we look at this 583 00:23:18,800 --> 00:23:22,560 alright there's a question here about 584 00:23:20,550 --> 00:23:23,760 the Russia's this this has been a 585 00:23:22,560 --> 00:23:26,340 program that has been under development 586 00:23:23,760 --> 00:23:28,350 for over a year and a half and remember 587 00:23:26,340 --> 00:23:29,550 we want to get this out as quickly as we 588 00:23:28,350 --> 00:23:31,680 can 589 00:23:29,550 --> 00:23:35,820 some of that is available budget time 590 00:23:31,680 --> 00:23:37,050 frame it's something we actually have to 591 00:23:35,820 --> 00:23:39,240 get done and we want to try and get it 592 00:23:37,050 --> 00:23:41,370 done as quickly as we can unfortunately 593 00:23:39,240 --> 00:23:43,830 that drive some of the crunch that we 594 00:23:41,370 --> 00:23:45,000 have but we're trying to do our best so 595 00:23:43,830 --> 00:23:46,320 there's much information to the 596 00:23:45,000 --> 00:23:52,380 community about this given the 597 00:23:46,320 --> 00:23:53,790 constraints we're actually under do you 598 00:23:52,380 --> 00:23:55,590 want to take any of these Alistair's 599 00:23:53,790 --> 00:23:59,580 went through a FISMA complaint one get 600 00:23:55,590 --> 00:24:01,140 one if you want okay what we also do is 601 00:23:59,580 --> 00:24:03,870 there is a team here in the room and 602 00:24:01,140 --> 00:24:06,060 some of us from nih who are on the phone 603 00:24:03,870 --> 00:24:10,080 who have different capabilities and 604 00:24:06,060 --> 00:24:11,700 skill sets so we have our CIO of NHGRI 605 00:24:10,080 --> 00:24:13,650 and working very closely with us on 606 00:24:11,700 --> 00:24:16,080 development tourism Teresa Marquette from 607 00:24:13,650 --> 00:24:18,090 the contracts office at NHLBI Jeff 608 00:24:16,080 --> 00:24:20,610 Snyder also from NHLBI from the legal 609 00:24:18,090 --> 00:24:22,800 team there's Rachel Britt here from and 610 00:24:20,610 --> 00:24:24,750 felucca from our comms team Murray 611 00:24:22,800 --> 00:24:29,340 Norris who throwdini who's going to be 612 00:24:24,750 --> 00:24:31,530 handling the review myself and I think 613 00:24:29,340 --> 00:24:33,480 that's all we have on the phone slight 614 00:24:31,530 --> 00:24:36,450 Corrections Teresa Marquette from the 615 00:24:33,480 --> 00:24:39,210 agreements offers from NHLBI I am 616 00:24:36,450 --> 00:24:41,340 neither a grant officer or a contract 617 00:24:39,210 --> 00:24:43,830 officer so I'm agreements office or so 618 00:24:41,340 --> 00:24:45,780 that's why it aligns with the OTS okay 619 00:24:43,830 --> 00:24:48,600 and agreements office my apologies we 620 00:24:45,780 --> 00:24:51,210 also have negocio here from and HIV we 621 00:24:48,600 --> 00:24:53,820 have a full crew here that are looking 622 00:24:51,210 --> 00:24:56,880 at this whole ot so any other questions 623 00:24:53,820 --> 00:24:58,950 please so this is Alison so a question 624 00:24:56,880 --> 00:25:01,110 about is there's no compliance required 625 00:24:58,950 --> 00:25:04,470 the security requirements are the same 626 00:25:01,110 --> 00:25:07,200 as they are for all other extramural 627 00:25:04,470 --> 00:25:11,160 activities involving controlled access 628 00:25:07,200 --> 00:25:16,110 data so there's good documentation on 629 00:25:11,160 --> 00:25:19,980 the grass at NIH website on 630 00:25:16,110 --> 00:25:21,990 what's required for that great there's a 631 00:25:19,980 --> 00:25:23,549 question here about the limit of 21 632 00:25:21,990 --> 00:25:25,920 million or the project what is the limit 633 00:25:23,549 --> 00:25:27,840 on each individual project we don't we 634 00:25:25,920 --> 00:25:29,820 don't know we don't know you proposed 635 00:25:27,840 --> 00:25:33,780 what budget is and you have to justify 636 00:25:29,820 --> 00:25:35,910 what it is that you want to do one of 637 00:25:33,780 --> 00:25:39,980 the key personnel should be full-time 638 00:25:35,910 --> 00:25:43,110 for for the time that again if you if 639 00:25:39,980 --> 00:25:44,520 you assemble the team you decide what it 640 00:25:43,110 --> 00:25:45,929 is that you want to apply for and you 641 00:25:44,520 --> 00:25:48,480 decide what the percentage of that 642 00:25:45,929 --> 00:25:51,000 person is available for like all things 643 00:25:48,480 --> 00:25:52,860 at NIH so as you put in the request for 644 00:25:51,000 --> 00:25:54,630 your key personnel if they are already 645 00:25:52,860 --> 00:25:56,010 subject to one hundred and fifty percent 646 00:25:54,630 --> 00:25:57,660 of their time on other projects which 647 00:25:56,010 --> 00:25:59,910 will be asking for other support on this 648 00:25:57,660 --> 00:26:01,559 then that will be queried here so you 649 00:25:59,910 --> 00:26:02,790 better have those team members defined 650 00:26:01,559 --> 00:26:04,260 for the time that they are truly 651 00:26:02,790 --> 00:26:06,650 available in needed for this particular 652 00:26:04,260 --> 00:26:06,650 project 653 00:26:07,070 --> 00:26:22,320 the other question hello can you hear me 654 00:26:18,230 --> 00:26:25,230 sure yes so there's other questions that 655 00:26:22,320 --> 00:26:29,070 you have not addressed it's asking about 656 00:26:25,230 --> 00:26:31,320 the duration of this pilot stage is it 657 00:26:29,070 --> 00:26:34,340 to be for the entire three to four years 658 00:26:31,320 --> 00:26:38,190 or are you looking just at the initial 659 00:26:34,340 --> 00:26:40,440 180 days for stage 1 stage one is 180 660 00:26:38,190 --> 00:26:52,110 days and the whole program is three to 661 00:26:40,440 --> 00:26:54,120 four years at all okay other questions 662 00:26:52,110 --> 00:26:58,890 on from the phone if not I'm still 663 00:26:54,120 --> 00:27:03,480 looking at the ones in the chat box okay 664 00:26:58,890 --> 00:27:05,630 they're all here any other questions we 665 00:27:03,480 --> 00:27:05,630 have 666 00:27:10,550 --> 00:27:12,580 Oh 667 00:27:24,230 --> 00:27:30,120 yeah yep go ahead 668 00:27:27,450 --> 00:27:33,990 Tim's asking do you have an expectation 669 00:27:30,120 --> 00:27:36,180 that successful applicants have existing 670 00:27:33,990 --> 00:27:38,910 partnerships with users of one or more 671 00:27:36,180 --> 00:27:41,720 of the three data sets or do you expect 672 00:27:38,910 --> 00:27:44,250 that to be a key component of stage one 673 00:27:41,720 --> 00:27:47,010 those are at formation of both 674 00:27:44,250 --> 00:27:48,570 partnerships soapy boats if you have 675 00:27:47,010 --> 00:27:50,790 part if you already have relationships 676 00:27:48,570 --> 00:27:53,100 with those folks that's great 677 00:27:50,790 --> 00:27:54,810 but we will also create those out of 678 00:27:53,100 --> 00:27:55,860 words but we don't want to do is bias 679 00:27:54,810 --> 00:28:03,570 people that don't have those 680 00:27:55,860 --> 00:28:05,040 relationships hi Vivian can you hear me 681 00:28:03,570 --> 00:28:08,760 yes I can 682 00:28:05,040 --> 00:28:11,070 yeah one question I have is can you can 683 00:28:08,760 --> 00:28:12,990 you tell us what drove the decision to 684 00:28:11,070 --> 00:28:15,090 chose that to choose the data sets that 685 00:28:12,990 --> 00:28:18,390 you're representing and asking us to 686 00:28:15,090 --> 00:28:21,060 work with yeah I think leadership was 687 00:28:18,390 --> 00:28:24,260 looking at a collection of what high 688 00:28:21,060 --> 00:28:27,240 value high volume data sets and those 689 00:28:24,260 --> 00:28:28,950 why because storage of these data sets 690 00:28:27,240 --> 00:28:30,600 is becoming problematic and being able 691 00:28:28,950 --> 00:28:33,690 to access them so top net is obviously 692 00:28:30,600 --> 00:28:35,610 very large as is G text mods is smaller 693 00:28:33,690 --> 00:28:38,610 but it's a high-value data set that gets 694 00:28:35,610 --> 00:28:40,320 high usage and so what the NIH 695 00:28:38,610 --> 00:28:42,210 leadership and by that I mean Francis 696 00:28:40,320 --> 00:28:44,460 Collins and a collection of the other 697 00:28:42,210 --> 00:28:46,950 Institute directors were looking at what 698 00:28:44,460 --> 00:28:49,410 would be a good test case for this so 699 00:28:46,950 --> 00:28:52,770 those would show those reasons and again 700 00:28:49,410 --> 00:28:55,080 they covered but really we realized they 701 00:28:52,770 --> 00:28:57,240 are genomics-based and we realize that 702 00:28:55,080 --> 00:28:59,670 we have to expand a little more than 703 00:28:57,240 --> 00:29:01,560 that in the future so maybe I can 704 00:28:59,670 --> 00:29:03,180 address a question that came in through 705 00:29:01,560 --> 00:29:04,680 a couple of different sources and it was 706 00:29:03,180 --> 00:29:09,120 asked in a couple of different ways and 707 00:29:04,680 --> 00:29:11,580 that is additional data set so let's 708 00:29:09,120 --> 00:29:14,160 first address what's in the solicitation 709 00:29:11,580 --> 00:29:15,870 specifically again if I'm repeating 710 00:29:14,160 --> 00:29:17,910 myself I'm doing this on purpose so that 711 00:29:15,870 --> 00:29:19,200 we can hopefully be clear and if you 712 00:29:17,910 --> 00:29:20,310 just hear me say it again again you know 713 00:29:19,200 --> 00:29:22,260 that I've said it that's good because 714 00:29:20,310 --> 00:29:24,780 hopefully you understand it so those 715 00:29:22,260 --> 00:29:26,880 three data sets we've chosen top medgie 716 00:29:24,780 --> 00:29:28,200 text and mods were chosen for the 717 00:29:26,880 --> 00:29:31,500 reasons I just said but in the 718 00:29:28,200 --> 00:29:33,210 solicitation I also say that if you have 719 00:29:31,500 --> 00:29:35,310 additional data sets that are relevant 720 00:29:33,210 --> 00:29:37,350 to expanding or understanding this 721 00:29:35,310 --> 00:29:39,660 project you are welcome 722 00:29:37,350 --> 00:29:43,080 they have to be extremely well justified 723 00:29:39,660 --> 00:29:44,730 and it's not a case of bringing those 724 00:29:43,080 --> 00:29:46,200 datasets in just because you want to 725 00:29:44,730 --> 00:29:48,750 bring an additional data set they have 726 00:29:46,200 --> 00:29:50,039 to be ancillary to and supportive of the 727 00:29:48,750 --> 00:29:52,500 work that we're doing with the original 728 00:29:50,039 --> 00:29:55,140 free so the questions that I've received 729 00:29:52,500 --> 00:29:57,960 outside some of the questions are can I 730 00:29:55,140 --> 00:29:59,460 bring new datasets the answer is no 731 00:29:57,960 --> 00:30:01,140 except under the context of the 732 00:29:59,460 --> 00:30:03,870 solicitation if it's put up the 733 00:30:01,140 --> 00:30:05,610 different datasets we have another 734 00:30:03,870 --> 00:30:07,860 question is do you have plans for 735 00:30:05,610 --> 00:30:10,169 additional data sets not at this time in 736 00:30:07,860 --> 00:30:12,450 the pilot but we're fully aware that 737 00:30:10,169 --> 00:30:14,039 this is the kind of project that we're 738 00:30:12,450 --> 00:30:16,110 you know there are more than obviously 739 00:30:14,039 --> 00:30:21,720 these three data sets that are large and 740 00:30:16,110 --> 00:30:23,460 of high value we are very good at and we 741 00:30:21,720 --> 00:30:25,500 expect to have some communication with 742 00:30:23,460 --> 00:30:27,240 the community a little later hopefully 743 00:30:25,500 --> 00:30:29,789 sometime this year if not early next 744 00:30:27,240 --> 00:30:31,350 year to engage with the community to 745 00:30:29,789 --> 00:30:33,090 have a better understanding of the kind 746 00:30:31,350 --> 00:30:35,250 of datasets that they might like to see 747 00:30:33,090 --> 00:30:37,650 up there and the kind of priorities 748 00:30:35,250 --> 00:30:39,480 associated with those and the kind of 749 00:30:37,650 --> 00:30:43,200 reasoning about why those datasets would 750 00:30:39,480 --> 00:30:44,909 be made available so I think that covers 751 00:30:43,200 --> 00:30:46,710 some of the questions I've been asked in 752 00:30:44,909 --> 00:30:50,250 the various flavors in relation to data 753 00:30:46,710 --> 00:30:51,530 sets I hope that helped I've been asked 754 00:30:50,250 --> 00:30:53,549 to look at what's the one about 755 00:30:51,530 --> 00:30:59,720 multi-institution can you scroll back up 756 00:30:53,549 --> 00:31:01,679 to that please can you confirm that 757 00:30:59,720 --> 00:31:03,960 multi-institution team should respond 758 00:31:01,679 --> 00:31:05,789 with a single joint ottawa it's three or 759 00:31:03,960 --> 00:31:13,850 separate LOI yes we would like you to 760 00:31:05,789 --> 00:31:13,850 come in with one LOI any other question 761 00:31:29,070 --> 00:31:31,550 pedal 762 00:31:33,660 --> 00:31:39,630 oh hi yes Vivian I do have another 763 00:31:37,410 --> 00:31:43,920 question can you hear me yes I can hear 764 00:31:39,630 --> 00:31:47,190 you clearly so I think certainly for 765 00:31:43,920 --> 00:31:50,790 myself and perhaps many others in 766 00:31:47,190 --> 00:31:53,550 looking at the sponsoring Institute for 767 00:31:50,790 --> 00:31:56,760 this announcement as we began to think 768 00:31:53,550 --> 00:31:59,600 about scientific use cases you know we 769 00:31:56,760 --> 00:32:02,370 were trying to reconcile the datasets 770 00:31:59,600 --> 00:32:04,860 that you're asking us to draw from and 771 00:32:02,370 --> 00:32:08,100 and then constructing scientific use 772 00:32:04,860 --> 00:32:10,500 cases that were supportive of programs 773 00:32:08,100 --> 00:32:13,350 and an agenda that were resident within 774 00:32:10,500 --> 00:32:15,990 heart lung blood institute and you know 775 00:32:13,350 --> 00:32:17,430 at least you know in my case when 776 00:32:15,990 --> 00:32:19,100 looking at some of those data sets I 777 00:32:17,430 --> 00:32:21,000 don't think it was intuitively obvious 778 00:32:19,100 --> 00:32:24,480 particularly as we were from seeing 779 00:32:21,000 --> 00:32:27,270 broad data set and linked out to the 780 00:32:24,480 --> 00:32:29,640 Alliance genome resource well most of 781 00:32:27,270 --> 00:32:33,210 the data was was heavily circumscribed 782 00:32:29,640 --> 00:32:35,550 around neuronal disorders and so there 783 00:32:33,210 --> 00:32:38,310 was a bit of a disconnect for me can you 784 00:32:35,550 --> 00:32:39,690 can you speak to that I don't actually 785 00:32:38,310 --> 00:32:41,550 quite understand what your question is 786 00:32:39,690 --> 00:32:43,050 is it that you're concerned about the 787 00:32:41,550 --> 00:32:44,310 data set and the content of it that you 788 00:32:43,050 --> 00:32:45,810 can't actually develop a use case 789 00:32:44,310 --> 00:32:48,440 because you're not close to the data or 790 00:32:45,810 --> 00:32:48,440 is it something different 791 00:32:51,410 --> 00:32:54,650 does that make sense 792 00:32:56,570 --> 00:33:00,900 gentleman who just asked that question 793 00:32:58,320 --> 00:33:02,400 yeah I'm sorry it looks like I drove a 794 00:33:00,900 --> 00:33:05,160 commute but no it was less about 795 00:33:02,400 --> 00:33:07,500 proximity but more so about the 796 00:33:05,160 --> 00:33:10,320 relevancy of the data to a particular 797 00:33:07,500 --> 00:33:14,610 disease there that might be an interest 798 00:33:10,320 --> 00:33:18,000 to heart lung blood and and so whereas top 799 00:33:14,610 --> 00:33:21,270 med clearly represents that those types 800 00:33:18,000 --> 00:33:24,300 of data that you know at least in the 801 00:33:21,270 --> 00:33:27,680 case of the the the mod database it did 802 00:33:24,300 --> 00:33:31,200 not seem to contain data that was 803 00:33:27,680 --> 00:33:33,660 immediately relevant to that that might 804 00:33:31,200 --> 00:33:36,600 reside in Harlem Blood Institute and 805 00:33:33,660 --> 00:33:37,389 helped us a bit there but let me see if 806 00:33:36,600 --> 00:33:38,559 I can 807 00:33:37,389 --> 00:33:39,999 if looking to put yourself back on mute 808 00:33:38,559 --> 00:33:42,399 again because it's got no prints but 809 00:33:39,999 --> 00:33:44,919 shows that animal sigasi is here from 810 00:33:42,399 --> 00:33:47,440 NHLBI from the top new project from 811 00:33:44,919 --> 00:33:49,959 another scientific leader so first of 812 00:33:47,440 --> 00:33:50,859 all the datasets are not necessary if 813 00:33:49,959 --> 00:33:53,379 you want to look at a use case for 814 00:33:50,859 --> 00:33:56,079 therapeutic a use case that was put in 815 00:33:53,379 --> 00:33:57,059 the OT was just an example it's not 816 00:33:56,079 --> 00:33:59,320 limited to that 817 00:33:57,059 --> 00:34:01,179 example of what you may want to consider 818 00:33:59,320 --> 00:34:03,459 it has a therapeutic bench 819 00:34:01,179 --> 00:34:05,079 if that's not folders that's not the 820 00:34:03,459 --> 00:34:08,769 intent for any of the other use cases 821 00:34:05,079 --> 00:34:10,569 the mods obviously are further away and 822 00:34:08,769 --> 00:34:14,859 more in understanding human disease 823 00:34:10,569 --> 00:34:16,779 overall and human genome structure then 824 00:34:14,859 --> 00:34:18,159 it would be necessarily for a specific 825 00:34:16,779 --> 00:34:20,679 disease although one can argue that as 826 00:34:18,159 --> 00:34:22,750 well so it's really a case of what would 827 00:34:20,679 --> 00:34:24,190 you want to what questions had to be 828 00:34:22,750 --> 00:34:26,289 question would you want to address based 829 00:34:24,190 --> 00:34:28,179 on any of those data sets rather than 830 00:34:26,289 --> 00:34:32,289 ups and having a particular slant that 831 00:34:28,179 --> 00:34:33,730 we want to take yeah and this is how I 832 00:34:32,289 --> 00:34:36,099 want everyone to recognize that 833 00:34:33,730 --> 00:34:37,929 especially for top med and gtex which 834 00:34:36,099 --> 00:34:40,599 are the data and I'm most familiar with 835 00:34:37,929 --> 00:34:43,629 top med all of the cohorts that have 836 00:34:40,599 --> 00:34:45,819 gone into the top med program are very 837 00:34:43,629 --> 00:34:48,690 diverse and I think we're not 838 00:34:45,819 --> 00:34:51,879 limited to Heart Lung and Blood there's 839 00:34:48,690 --> 00:34:53,619 really just a wide gamut of phenotypes 840 00:34:51,879 --> 00:34:54,759 almost anything you can think of 841 00:34:53,619 --> 00:34:57,190 especially from the Framingham study 842 00:34:54,759 --> 00:34:59,019 that's been in existence for so long but 843 00:34:57,190 --> 00:35:01,089 also for a lot of the other cohort 844 00:34:59,019 --> 00:35:06,250 studies so I really think the sky's the 845 00:35:01,089 --> 00:35:08,529 limit and with the the sub clinical 846 00:35:06,250 --> 00:35:11,950 measures the imaging data just really 847 00:35:08,529 --> 00:35:15,789 there is so much information in a lot of 848 00:35:11,950 --> 00:35:17,890 the top med studies that opens up the 849 00:35:15,789 --> 00:35:21,599 flexibility to connect it with other 850 00:35:17,890 --> 00:35:23,890 data sets such as mods so the creativity 851 00:35:21,599 --> 00:35:26,470 from the research community is what 852 00:35:23,890 --> 00:35:28,509 we're hoping for to see those potential 853 00:35:26,470 --> 00:35:32,740 see that potential and what makes 854 00:35:28,509 --> 00:35:37,630 predictions Thanks does that help answer 855 00:35:32,740 --> 00:35:41,109 your question it does thank you very 856 00:35:37,630 --> 00:35:44,019 much appreciate that i don't livi 857 00:35:41,109 --> 00:35:45,640 ongoing question I got a second I went 858 00:35:44,019 --> 00:35:48,400 just night it's got something to add and 859 00:35:45,640 --> 00:35:48,750 then after that Owen please see there 860 00:35:48,400 --> 00:35:50,640 was a 861 00:35:48,750 --> 00:35:52,650 about whether or not participation in 862 00:35:50,640 --> 00:35:54,060 phase one would implicate a potential 863 00:35:52,650 --> 00:35:55,560 organizational conflict of interest 864 00:35:54,060 --> 00:35:58,170 issue in Phase two and the answer that 865 00:35:55,560 --> 00:36:05,340 is no participation phase but would not 866 00:35:58,170 --> 00:36:07,260 see is even product to peddle all right 867 00:36:05,340 --> 00:36:09,630 oh and one last question from you but 868 00:36:07,260 --> 00:36:11,640 before you do that I've been asked here 869 00:36:09,630 --> 00:36:13,620 just in terms of fairness of all 870 00:36:11,640 --> 00:36:14,940 participants that we prefer to have 871 00:36:13,620 --> 00:36:18,000 everything done through the chat box 872 00:36:14,940 --> 00:36:19,860 sequester simply it depends on who is 873 00:36:18,000 --> 00:36:21,660 able to unmute and create some issues 874 00:36:19,860 --> 00:36:22,890 there's hope because you opto and you're 875 00:36:21,660 --> 00:36:24,840 the last one to do that and then we'll 876 00:36:22,890 --> 00:36:25,430 go back to the chat box so go for it 877 00:36:24,840 --> 00:36:28,230 Louis 878 00:36:25,430 --> 00:36:30,540 well to be brief in was a question based 879 00:36:28,230 --> 00:36:34,680 on it to me one that was already asked 880 00:36:30,540 --> 00:36:37,890 about 4,000 words per key component or 881 00:36:34,680 --> 00:36:40,170 for the entire proposal and I'll jump 882 00:36:37,890 --> 00:36:44,670 off line okay thanks 883 00:36:40,170 --> 00:36:48,570 okay hi this is um this is Marie and 884 00:36:44,670 --> 00:36:50,610 this is a question this very Yaris and 885 00:36:48,570 --> 00:36:53,820 I'm acting as a review of the sir for 886 00:36:50,610 --> 00:36:56,700 this this is a question for that 887 00:36:53,820 --> 00:36:59,460 pertains to the full application whether 888 00:36:56,700 --> 00:37:03,990 it's not to exceed four thousand words 889 00:36:59,460 --> 00:37:10,860 and two figures and it says per key 890 00:37:03,990 --> 00:37:13,170 capability okay so just to reiterate 891 00:37:10,860 --> 00:37:14,820 again I'm going to be painful but just 892 00:37:13,170 --> 00:37:16,970 to be really clear here if we can take 893 00:37:14,820 --> 00:37:18,930 the question through the chat box please 894 00:37:16,970 --> 00:37:20,910 since it's just really difficult for 895 00:37:18,930 --> 00:37:22,530 people muting and unmuting alright I'll 896 00:37:20,910 --> 00:37:25,290 be looking at the check box deployment 897 00:37:22,530 --> 00:37:26,610 so there's a question there about 898 00:37:25,290 --> 00:37:28,710 whether can existing commercial 899 00:37:26,610 --> 00:37:30,690 intellectual property be incorporated 900 00:37:28,710 --> 00:37:33,660 into a proposed solution what are the 901 00:37:30,690 --> 00:37:37,050 ramifications the foundations for the 902 00:37:33,660 --> 00:37:40,730 data Commons must be open source all the 903 00:37:37,050 --> 00:37:42,870 core components must be open source 904 00:37:40,730 --> 00:37:46,440 organizations with IP are welcome to 905 00:37:42,870 --> 00:37:47,760 contribute them however they may they 906 00:37:46,440 --> 00:37:50,790 would have to contribute them in the 907 00:37:47,760 --> 00:37:52,830 form of open source with that said we 908 00:37:50,790 --> 00:37:55,530 anticipate the commercial organizations 909 00:37:52,830 --> 00:37:57,660 will build products on top of the data 910 00:37:55,530 --> 00:37:59,850 Commons that are not part of the data 911 00:37:57,660 --> 00:38:02,500 Commons but we encourage them to 912 00:37:59,850 --> 00:38:12,490 leverage it with their own eye 913 00:38:02,500 --> 00:38:13,869 P in the interest of the community right 914 00:38:12,490 --> 00:38:15,820 we have another question here about 915 00:38:13,869 --> 00:38:17,619 budget I'm just going to say what I've 916 00:38:15,820 --> 00:38:21,630 said before and the question around 917 00:38:17,619 --> 00:38:24,040 budget was I know you've scrolled up 918 00:38:21,630 --> 00:38:28,020 okay the question on budget again was 919 00:38:24,040 --> 00:38:30,820 what's the limit how do I justify that 920 00:38:28,020 --> 00:38:32,710 but trying to look for it on the chat 921 00:38:30,820 --> 00:38:35,740 box I hope it came along the same thing 922 00:38:32,710 --> 00:38:38,890 and I've also had questions and sent to 923 00:38:35,740 --> 00:38:40,990 our mailbox along that line there we go 924 00:38:38,890 --> 00:38:43,690 can you outline the kind of items you 925 00:38:40,990 --> 00:38:46,330 expect in stage one budget again I think 926 00:38:43,690 --> 00:38:49,060 it's depending what you want to do the 927 00:38:46,330 --> 00:38:50,859 idea behind this is to not predefined 928 00:38:49,060 --> 00:38:54,090 how we're going to do the comments the 929 00:38:50,859 --> 00:38:57,760 idea here is community to self organize 930 00:38:54,090 --> 00:38:59,470 in groups individuals as otherwise of 931 00:38:57,760 --> 00:39:01,750 how you would approach this and there's 932 00:38:59,470 --> 00:39:03,940 a very strong reason for that we don't 933 00:39:01,750 --> 00:39:06,400 want to overly prescribe this kind of 934 00:39:03,940 --> 00:39:07,630 work some of the folks on the line know 935 00:39:06,400 --> 00:39:09,550 this is the kind of work that I've been 936 00:39:07,630 --> 00:39:11,500 doing for a couple of years but I'm very 937 00:39:09,550 --> 00:39:13,630 strongly of the opinion that and I think 938 00:39:11,500 --> 00:39:14,950 the rest of NIH feels the same way being 939 00:39:13,630 --> 00:39:16,390 prescriptive from the government 940 00:39:14,950 --> 00:39:20,020 perspective is not what we want to do 941 00:39:16,390 --> 00:39:21,640 but ensure the best ideas from the 942 00:39:20,020 --> 00:39:24,640 community and how they would approach 943 00:39:21,640 --> 00:39:27,070 that so if you want to look at just one 944 00:39:24,640 --> 00:39:28,599 of the key capabilities and you only say 945 00:39:27,070 --> 00:39:30,099 a small business that you feel very 946 00:39:28,599 --> 00:39:31,990 strongly that you've got great 947 00:39:30,099 --> 00:39:34,000 capabilities in that and your budget 948 00:39:31,990 --> 00:39:35,560 isn't very big because it's a small 949 00:39:34,000 --> 00:39:37,869 component but it's a critical one and 950 00:39:35,560 --> 00:39:39,400 you do that very well that's okay we're 951 00:39:37,869 --> 00:39:41,170 not going to judge that poorly against 952 00:39:39,400 --> 00:39:43,690 another consortium group that comes in 953 00:39:41,170 --> 00:39:45,220 with a much larger budget your budget is 954 00:39:43,690 --> 00:39:47,530 going to be based upon what you're 955 00:39:45,220 --> 00:39:50,680 proposing how you plan to do that how 956 00:39:47,530 --> 00:39:52,270 well you can justify that obviously 957 00:39:50,680 --> 00:39:53,470 we've got a limit in the kind of budget 958 00:39:52,270 --> 00:39:54,910 we have where we will presumably 959 00:39:53,470 --> 00:39:57,220 wouldn't be looking at one proposal that 960 00:39:54,910 --> 00:39:59,200 21 million that's obviously not what 961 00:39:57,220 --> 00:40:01,180 we're going to do but we're also being 962 00:39:59,200 --> 00:40:03,190 trying to be open in both the approach 963 00:40:01,180 --> 00:40:05,650 that you want to take and tell us what 964 00:40:03,190 --> 00:40:08,440 budget you would justify you did have 965 00:40:05,650 --> 00:40:11,530 some questions which I've had in a lot 966 00:40:08,440 --> 00:40:13,210 of those asking about consulting for 967 00:40:11,530 --> 00:40:15,700 sure as folks that come from academia 968 00:40:13,210 --> 00:40:16,059 and commercial companies we're very well 969 00:40:15,700 --> 00:40:18,189 aware 970 00:40:16,059 --> 00:40:20,680 the commercial rates are higher and they 971 00:40:18,189 --> 00:40:22,239 are different again all we're asking is 972 00:40:20,680 --> 00:40:23,859 justify what it is that you're 973 00:40:22,239 --> 00:40:25,539 suggesting you want to do and how you 974 00:40:23,859 --> 00:40:27,069 want to do that we're aware that 975 00:40:25,539 --> 00:40:29,079 industry does that that is also the 976 00:40:27,069 --> 00:40:31,329 reason why we're using an OT we want to 977 00:40:29,079 --> 00:40:32,680 encourage collections of different 978 00:40:31,329 --> 00:40:35,049 businesses with different capabilities 979 00:40:32,680 --> 00:40:47,170 and different types to actually work 980 00:40:35,049 --> 00:40:48,400 with us all right all right then Preston 981 00:40:47,170 --> 00:40:49,959 you're in addition of assistive 982 00:40:48,400 --> 00:40:52,180 development how much effort would you 983 00:40:49,959 --> 00:40:56,140 expect for evaluations do we not scroll 984 00:40:52,180 --> 00:40:57,729 down thank you Rob I got all right 985 00:40:56,140 --> 00:41:00,130 addition assistant develop how much if 986 00:40:57,729 --> 00:41:02,249 it were would you expect an evaluation 987 00:41:00,130 --> 00:41:06,579 in terms of feasibility and performance 988 00:41:02,249 --> 00:41:08,619 I think phase one is all about figuring 989 00:41:06,579 --> 00:41:11,259 out what we're going to do and so 990 00:41:08,619 --> 00:41:12,939 therefore in your LOI and those who go 991 00:41:11,259 --> 00:41:14,890 to the application phase we're asking 992 00:41:12,939 --> 00:41:16,869 you for really clear justifications of 993 00:41:14,890 --> 00:41:19,420 what you would want to do and why you 994 00:41:16,869 --> 00:41:21,069 would want to do that so systems 995 00:41:19,420 --> 00:41:22,599 development will be dependent upon what 996 00:41:21,069 --> 00:41:26,380 we see as a set of plans that are 997 00:41:22,599 --> 00:41:29,019 valuable to attain keep in mind for 998 00:41:26,380 --> 00:41:31,029 small short prototypes that give us an 999 00:41:29,019 --> 00:41:33,339 evaluation of how we could get where we 1000 00:41:31,029 --> 00:41:35,410 need to go so there's a lot of 1001 00:41:33,339 --> 00:41:37,179 Technology testing that has to occur in 1002 00:41:35,410 --> 00:41:40,449 the computer environments 1003 00:41:37,179 --> 00:41:42,670 there's also protocols for handling 1004 00:41:40,449 --> 00:41:45,609 authentication tourism is also 1005 00:41:42,670 --> 00:41:47,229 components therefore obviously API so we 1006 00:41:45,609 --> 00:41:48,160 speak about this in the OTA about the 1007 00:41:47,229 --> 00:41:51,009 way the Atos 1008 00:41:48,160 --> 00:41:53,709 the api's will connect to data to the 1009 00:41:51,009 --> 00:41:55,359 services associated to that so there 1010 00:41:53,709 --> 00:41:57,039 will be some development upon that but 1011 00:41:55,359 --> 00:41:59,349 what we don't want to do is create one 1012 00:41:57,039 --> 00:42:01,299 large monolithic system we want to test 1013 00:41:59,349 --> 00:42:03,009 the various components for doing that 1014 00:42:01,299 --> 00:42:04,689 and we're fully aware that having 1015 00:42:03,009 --> 00:42:06,400 multiple groups makes that somewhat 1016 00:42:04,689 --> 00:42:07,900 harder in doing that but at the same 1017 00:42:06,400 --> 00:42:10,569 time we're engaging a broader community 1018 00:42:07,900 --> 00:42:12,489 and actually getting to an understanding 1019 00:42:10,569 --> 00:42:15,279 what we could do that is why we want 1020 00:42:12,489 --> 00:42:16,929 various people to work together in terms 1021 00:42:15,279 --> 00:42:18,819 of this development I don't know what 1022 00:42:16,929 --> 00:42:20,199 that's going to be once we come together 1023 00:42:18,819 --> 00:42:22,299 as a consortium some of those 1024 00:42:20,199 --> 00:42:24,789 definitions will be done what you have 1025 00:42:22,299 --> 00:42:27,309 to show in your replication or ulo a 1026 00:42:24,789 --> 00:42:29,140 digital capacity and your capability to 1027 00:42:27,309 --> 00:42:29,470 address those issues that you have to 1028 00:42:29,140 --> 00:42:32,290 show 1029 00:42:29,470 --> 00:42:33,609 really because whatever we go to going 1030 00:42:32,290 --> 00:42:35,650 to have to be able to leverage what is 1031 00:42:33,609 --> 00:42:41,440 said that you could do in your LOI on 1032 00:42:35,650 --> 00:42:43,270 your application oh hi this is Murray 1033 00:42:41,440 --> 00:42:44,530 again I just wanted to answer the 1034 00:42:43,270 --> 00:42:47,340 question about whether or not 1035 00:42:44,530 --> 00:42:50,619 international organisations can apply 1036 00:42:47,340 --> 00:42:54,270 yes international organizations may 1037 00:42:50,619 --> 00:42:56,590 apply 1038 00:42:54,270 --> 00:42:58,390 Thank You Marie I also realized that 1039 00:42:56,590 --> 00:43:00,220 there is no problem as far as I 1040 00:42:58,390 --> 00:43:03,609 understand to have international 1041 00:43:00,220 --> 00:43:06,849 collaborations working with the books as 1042 00:43:03,609 --> 00:43:09,280 leaves as however you wish to organize 1043 00:43:06,849 --> 00:43:11,410 we realize that our colleagues in 1044 00:43:09,280 --> 00:43:13,240 overseas places have different 1045 00:43:11,410 --> 00:43:15,700 technologies and skills and there are 1046 00:43:13,240 --> 00:43:17,260 some parallel efforts here and where 1047 00:43:15,700 --> 00:43:18,550 possible we'd like to reuse some of 1048 00:43:17,260 --> 00:43:20,170 those we're aware of some of the 1049 00:43:18,550 --> 00:43:22,000 standards that are being used in various 1050 00:43:20,170 --> 00:43:23,830 parts of the world and if they've had 1051 00:43:22,000 --> 00:43:26,170 applications of those they don't 1052 00:43:23,830 --> 00:43:27,880 necessarily need to be shown as only us 1053 00:43:26,170 --> 00:43:33,910 they can be outside of that and we would 1054 00:43:27,880 --> 00:43:36,720 encourage that okay I'm just looking at 1055 00:43:33,910 --> 00:43:36,720 hosting phonecopy 1056 00:43:45,150 --> 00:43:49,809 I'm going to read this out one out aloud 1057 00:43:47,410 --> 00:43:52,720 so that a primary concern in the past 1058 00:43:49,809 --> 00:43:57,520 for cloud replay to be used of cloud 1059 00:43:52,720 --> 00:43:59,920 resources by a global community I'm not 1060 00:43:57,520 --> 00:44:02,020 entirely sure what that means 1061 00:43:59,920 --> 00:44:04,540 LC you might have it so the quest is 1062 00:44:02,020 --> 00:44:07,150 really about cost control unit from so 1063 00:44:04,540 --> 00:44:10,000 one of the areas for us to be looking at 1064 00:44:07,150 --> 00:44:13,510 in this particularly in phase two will 1065 00:44:10,000 --> 00:44:18,130 be implementing some form of cost 1066 00:44:13,510 --> 00:44:20,099 control so there as you know that we can 1067 00:44:18,130 --> 00:44:22,170 connect see manage the risk of 1068 00:44:20,099 --> 00:44:26,440 accelerating costs and cloud resources 1069 00:44:22,170 --> 00:44:29,589 we also anticipate that many will want 1070 00:44:26,440 --> 00:44:32,920 to bring their own compute resources to 1071 00:44:29,589 --> 00:44:34,750 the clouds in order to leverage 1072 00:44:32,920 --> 00:44:37,720 agreements that they already have which 1073 00:44:34,750 --> 00:44:40,270 will also assist will with their write 1074 00:44:37,720 --> 00:44:41,859 another one issue about costs and this 1075 00:44:40,270 --> 00:44:43,589 is something that NIH is trying to 1076 00:44:41,859 --> 00:44:46,839 determine from understanding this pilot 1077 00:44:43,589 --> 00:44:49,390 we've had multiple examples over the 1078 00:44:46,839 --> 00:44:52,180 last period of time certainly wanted to 1079 00:44:49,390 --> 00:44:55,059 you noticed people moving large datasets 1080 00:44:52,180 --> 00:44:57,940 onto public clouds for a period of time 1081 00:44:55,059 --> 00:44:59,470 and then removing them there are obvious 1082 00:44:57,940 --> 00:45:01,660 reason to that cost is one of those 1083 00:44:59,470 --> 00:45:04,000 because you cannot maintain that it's 1084 00:45:01,660 --> 00:45:06,700 too expensive to maintain it on public 1085 00:45:04,000 --> 00:45:08,829 resources NIH is aware of that and one 1086 00:45:06,700 --> 00:45:10,720 of the things we're looking at is can 1087 00:45:08,829 --> 00:45:13,000 what is the cost to maintain a highly 1088 00:45:10,720 --> 00:45:15,730 used data set the large or small on 1089 00:45:13,000 --> 00:45:18,520 these environments and those costs to be 1090 00:45:15,730 --> 00:45:20,710 borne by NIH because that way we can 1091 00:45:18,520 --> 00:45:22,780 best facilitate biomedical research that 1092 00:45:20,710 --> 00:45:25,480 you're not bearing the cost off simply 1093 00:45:22,780 --> 00:45:27,150 that the storage aspect of that there's 1094 00:45:25,480 --> 00:45:30,460 one of the things that we're trying to 1095 00:45:27,150 --> 00:45:32,559 pilot so there's a cost issue there it's 1096 00:45:30,460 --> 00:45:34,960 the storage one understanding which 1097 00:45:32,559 --> 00:45:37,510 storage to use whether it's online 1098 00:45:34,960 --> 00:45:38,710 Nearline offline etc is part of what we 1099 00:45:37,510 --> 00:45:40,690 want to understand to you what is the 1100 00:45:38,710 --> 00:45:43,720 cost of storing in different individual 1101 00:45:40,690 --> 00:45:45,490 clouds how does that cost us we rare 1102 00:45:43,720 --> 00:45:47,920 they're also costs within some of these 1103 00:45:45,490 --> 00:45:49,180 systems what are those costs where do 1104 00:45:47,920 --> 00:45:51,369 they come and where are they getting 1105 00:45:49,180 --> 00:45:54,220 charged we're understanding that 1106 00:45:51,369 --> 00:45:56,619 researchers have as they get their 1107 00:45:54,220 --> 00:45:58,449 standard are ones with many institution 1108 00:45:56,619 --> 00:46:00,309 a lot of the compute costs are getting 1109 00:45:58,449 --> 00:46:02,319 sucked up in storage and use of computes 1110 00:46:00,309 --> 00:46:04,630 and therefore not much as left in those 1111 00:46:02,319 --> 00:46:06,059 are ones to do the actual science so 1112 00:46:04,630 --> 00:46:09,519 we're trying to understand how to fit 1113 00:46:06,059 --> 00:46:11,140 these new environments to better serve 1114 00:46:09,519 --> 00:46:12,459 the community and that's part of the 1115 00:46:11,140 --> 00:46:14,380 issues we're trying to understand all of 1116 00:46:12,459 --> 00:46:16,959 those cost issues the flip side of that 1117 00:46:14,380 --> 00:46:18,969 is the compute so obviously we need to 1118 00:46:16,959 --> 00:46:20,650 be able to pay for that compute and how 1119 00:46:18,969 --> 00:46:23,559 to do that is so part of what we'd like 1120 00:46:20,650 --> 00:46:26,829 to understand if that happens what's the 1121 00:46:23,559 --> 00:46:29,199 best route for that to be attractive in 1122 00:46:26,829 --> 00:46:31,390 the process of understanding that work 1123 00:46:29,199 --> 00:46:32,680 there's several pilots already going on 1124 00:46:31,390 --> 00:46:33,759 that we're testing and we'll be able to 1125 00:46:32,680 --> 00:46:36,009 explain a little bit more to the 1126 00:46:33,759 --> 00:46:39,009 community of type flow about the compute 1127 00:46:36,009 --> 00:46:41,170 side of it the whole focus on the cost 1128 00:46:39,009 --> 00:46:43,719 is where does the government pay for 1129 00:46:41,170 --> 00:46:45,729 certain storage and why what does it 1130 00:46:43,719 --> 00:46:48,910 cost us to maintain these data sets over 1131 00:46:45,729 --> 00:46:50,619 time and why how do we use those and how 1132 00:46:48,910 --> 00:46:53,380 do we best serve the community in the 1133 00:46:50,619 --> 00:46:55,420 longer term so that the use of the grant 1134 00:46:53,380 --> 00:46:58,660 dollars and the contract dollars goes 1135 00:46:55,420 --> 00:47:00,369 towards doing binodals but in a lot of 1136 00:46:58,660 --> 00:47:02,319 the overhead costs are going to 1137 00:47:00,369 --> 00:47:03,609 maintaining these we're aware of it and 1138 00:47:02,319 --> 00:47:08,890 that's part of what this project is 1139 00:47:03,609 --> 00:47:10,809 trying to define so the question would 1140 00:47:08,890 --> 00:47:12,519 sound like the intent is to provide a 1141 00:47:10,809 --> 00:47:14,319 data common software stack where 1142 00:47:12,519 --> 00:47:15,849 individuals can implement one or more 1143 00:47:14,319 --> 00:47:19,749 parts of the stack can you speak a 1144 00:47:15,849 --> 00:47:23,469 little on this well part of this is to 1145 00:47:19,749 --> 00:47:25,150 provide an environment where individuals 1146 00:47:23,469 --> 00:47:28,269 and organizations can innovate in terms 1147 00:47:25,150 --> 00:47:30,849 of what the software is the program goes 1148 00:47:28,269 --> 00:47:34,059 far beyond that it is designed to 1149 00:47:30,849 --> 00:47:35,619 provide a platform for science and part 1150 00:47:34,059 --> 00:47:38,769 of the demonstrations we'll be looking 1151 00:47:35,619 --> 00:47:40,209 for is how it addresses scientific is 1152 00:47:38,769 --> 00:47:43,329 capable of addressing scientific 1153 00:47:40,209 --> 00:47:46,150 questions not just it's an interesting 1154 00:47:43,329 --> 00:47:49,869 software stack that it's able to be 1155 00:47:46,150 --> 00:47:51,969 leveraged and that software spec happens 1156 00:47:49,869 --> 00:47:53,829 on two sides which is does it help with 1157 00:47:51,969 --> 00:47:55,509 cost and efficiency that's important 1158 00:47:53,829 --> 00:47:57,429 right if that can reduce it that's 1159 00:47:55,509 --> 00:48:00,130 important and the other side of that is 1160 00:47:57,429 --> 00:48:01,709 can you more easily be able to ask and 1161 00:48:00,130 --> 00:48:04,179 address biomedical questions 1162 00:48:01,709 --> 00:48:06,189 particularly because we recognize that 1163 00:48:04,179 --> 00:48:07,719 there are many biomedical scientists 1164 00:48:06,189 --> 00:48:09,670 supported by an act that don't have 1165 00:48:07,719 --> 00:48:10,630 strong computational backgrounds and we 1166 00:48:09,670 --> 00:48:12,849 wanting to make sure 1167 00:48:10,630 --> 00:48:15,759 you're at the right way to connect with 1168 00:48:12,849 --> 00:48:17,529 those folks anymore you know that we 1169 00:48:15,759 --> 00:48:20,200 can't develop this ginormous system to 1170 00:48:17,529 --> 00:48:22,420 start without various pieces and test it 1171 00:48:20,200 --> 00:48:23,890 and be small and agile and we realize 1172 00:48:22,420 --> 00:48:25,690 that some of the underlying technology 1173 00:48:23,890 --> 00:48:27,279 has to happen as we roll along and 1174 00:48:25,690 --> 00:48:29,229 probably has to happen first what we 1175 00:48:27,279 --> 00:48:31,059 cannot lose sight of the fact that we're 1176 00:48:29,229 --> 00:48:37,239 also trying to serve a broader diamond 1177 00:48:31,059 --> 00:48:41,309 Oh Murray again um no your LOI does not 1178 00:48:37,239 --> 00:48:46,109 need signing from your authorized 1179 00:48:41,309 --> 00:49:02,859 official you can stand an LOI in Oh 1180 00:48:46,109 --> 00:49:05,349 normally do thank you we're just reading 1181 00:49:02,859 --> 00:49:06,999 through the channel these are great 1182 00:49:05,349 --> 00:49:08,309 questions thank you keep setting them in 1183 00:49:06,999 --> 00:49:10,479 but I can't 1184 00:49:08,309 --> 00:49:26,259 unfortunately my brain is not a cloud 1185 00:49:10,479 --> 00:49:28,869 different difficulties with question is 1186 00:49:26,259 --> 00:49:30,819 because I represent a company not 1187 00:49:28,869 --> 00:49:33,960 involved in clinical medical find their 1188 00:49:30,819 --> 00:49:35,650 location element in solution to fear 1189 00:49:33,960 --> 00:49:37,869 providing workspaces and 1190 00:49:35,650 --> 00:49:40,089 interoperability and so forth it's such 1191 00:49:37,869 --> 00:49:42,369 an application of interest to NIH or for 1192 00:49:40,089 --> 00:49:45,219 not sure what okie off in that situation 1193 00:49:42,369 --> 00:49:49,450 so again we're part of the reason we're 1194 00:49:45,219 --> 00:49:52,210 using an OT is to Lebanon so follow the 1195 00:49:49,450 --> 00:49:53,680 projects has a lot of tank IT computing 1196 00:49:52,210 --> 00:49:57,009 components which is traditionally not 1197 00:49:53,680 --> 00:49:59,440 named and we are encouraging but often 1198 00:49:57,009 --> 00:50:02,410 on the background because if you have a 1199 00:49:59,440 --> 00:50:04,569 workspace and you have weighs nothing 1200 00:50:02,410 --> 00:50:06,279 the rebuilding can run and we could 1201 00:50:04,569 --> 00:50:10,420 leverage that then we encourage you to 1202 00:50:06,279 --> 00:50:14,559 apply not sure what the CI will be in 1203 00:50:10,420 --> 00:50:17,019 that situation you would be the pi5 - 1204 00:50:14,559 --> 00:50:17,650 they do the - capability related to 1205 00:50:17,019 --> 00:50:20,079 workspaces 1206 00:50:17,650 --> 00:50:22,930 so either role that you would have and 1207 00:50:20,079 --> 00:50:23,230 our trusty team here at NIH would help 1208 00:50:22,930 --> 00:50:25,869 you 1209 00:50:23,230 --> 00:50:30,400 you figure out how to navigate that X 1210 00:50:25,869 --> 00:50:33,450 that we got to have my photo I have the 1211 00:50:30,400 --> 00:50:37,390 traditional background of notes subtle 1212 00:50:33,450 --> 00:50:38,410 subtle bug just want to make sure you 1213 00:50:37,390 --> 00:50:39,700 don't go away 1214 00:50:38,410 --> 00:50:44,490 maybe you can't apply because you 1215 00:50:39,700 --> 00:50:48,310 haven't been a traditional NIH s applier 1216 00:50:44,490 --> 00:50:52,390 probably question about which are the 1217 00:50:48,310 --> 00:50:56,650 three ICS that were supporting this 1218 00:50:52,390 --> 00:51:00,820 initiative again those were NHLBI they 1219 00:50:56,650 --> 00:51:03,640 are glowing blood and blood NHGRI which 1220 00:51:00,820 --> 00:51:05,200 is the human genome Institute and Common 1221 00:51:03,640 --> 00:51:10,000 Fund which is in the Office of the 1222 00:51:05,200 --> 00:51:12,820 Director another question has come up to 1223 00:51:10,000 --> 00:51:14,859 me is about consortium yes you can form 1224 00:51:12,820 --> 00:51:16,750 them like an socialist be careful about 1225 00:51:14,859 --> 00:51:18,850 the nomenclature here groups that want 1226 00:51:16,750 --> 00:51:21,040 to form together to apply for one or 1227 00:51:18,850 --> 00:51:24,820 more of the key capabilities that's fine 1228 00:51:21,040 --> 00:51:28,450 if you want to do that we have that but 1229 00:51:24,820 --> 00:51:30,010 not the clearinghouse for doing that 1230 00:51:28,450 --> 00:51:31,750 we've had a number of questions about 1231 00:51:30,010 --> 00:51:33,340 whether we provide connection points for 1232 00:51:31,750 --> 00:51:35,560 other folks that is for you to decide 1233 00:51:33,340 --> 00:51:40,320 how you want to do that and to arrange 1234 00:51:35,560 --> 00:51:40,320 your organization's within that role 1235 00:51:41,490 --> 00:51:46,180 this is Jeff Snyder from NHLBI just add 1236 00:51:44,260 --> 00:51:48,130 on to that when you do form a consortium 1237 00:51:46,180 --> 00:51:49,990 it is often helpful if you have an 1238 00:51:48,130 --> 00:51:52,920 articles of collaboration or some sort 1239 00:51:49,990 --> 00:51:52,920 of teaming arrangement 1240 00:52:08,859 --> 00:52:25,280 yes question about your cases how they 1241 00:52:21,859 --> 00:52:29,990 would impact how would the youth type 1242 00:52:25,280 --> 00:52:37,160 impact Alexi that here actually impact 1243 00:52:29,990 --> 00:52:38,290 the developer the one I gave you is just 1244 00:52:37,160 --> 00:52:44,990 in his example 1245 00:52:38,290 --> 00:52:46,700 i won we're not confining it to that you 1246 00:52:44,990 --> 00:52:48,020 need to think about it in the context of 1247 00:52:46,700 --> 00:52:58,790 those data at this but we're not 1248 00:52:48,020 --> 00:53:05,750 limiting can you scroll down if there's 1249 00:52:58,790 --> 00:53:08,450 anyone oh okay looks to get a better 1250 00:53:05,750 --> 00:53:10,730 understand can't peer billion right here 1251 00:53:08,450 --> 00:53:14,290 you run out left because you stole my 1252 00:53:10,730 --> 00:53:14,290 name if you fill a lot of code 1253 00:53:18,220 --> 00:53:23,750 that's okay John I'm talking to that all 1254 00:53:23,570 --> 00:53:36,920 right 1255 00:53:23,750 --> 00:53:40,369 I've seen access to Tom maybe you wanna 1256 00:53:36,920 --> 00:53:42,890 check that they 1257 00:53:40,369 --> 00:53:45,920 could be available direct access to top 1258 00:53:42,890 --> 00:53:48,080 Med go to currently bottle top this 1259 00:53:45,920 --> 00:53:50,930 study center instead of become available 1260 00:53:48,080 --> 00:53:53,930 outside that mechanism so there is ComEd 1261 00:53:50,930 --> 00:53:58,849 data that is publicly available in DB 1262 00:53:53,930 --> 00:54:00,230 gap there's a the data address process 1263 00:53:58,849 --> 00:54:02,660 that has to be followed 1264 00:54:00,230 --> 00:54:05,630 so that's currently the way to get 1265 00:54:02,660 --> 00:54:07,220 access to the subset of the the first 1266 00:54:05,630 --> 00:54:11,930 release of the top net data that will be 1267 00:54:07,220 --> 00:54:14,570 publicly available if that is the group 1268 00:54:11,930 --> 00:54:17,300 working on this will be prized in the 1269 00:54:14,570 --> 00:54:20,810 impedance space of the pilot is to only 1270 00:54:17,300 --> 00:54:25,340 use their publicly accessible 9000 1271 00:54:20,810 --> 00:54:27,110 yeah location correct thank you there's 1272 00:54:25,340 --> 00:54:29,660 a question that us whether or not the 1273 00:54:27,110 --> 00:54:31,700 announcement is on that was 1274 00:54:29,660 --> 00:54:35,450 posted directly to the Common Fund 1275 00:54:31,700 --> 00:54:37,820 website we are issuing a guide to notice 1276 00:54:35,450 --> 00:54:39,440 that will go through but the 1277 00:54:37,820 --> 00:54:45,380 announcement itself is only on the 1278 00:54:39,440 --> 00:54:46,730 common fund website it's going to 1279 00:54:45,380 --> 00:54:48,260 address an issue that came up from the 1280 00:54:46,730 --> 00:54:50,570 question we just came up here it says 1281 00:54:48,260 --> 00:54:52,550 clearly between now and June 13 DS what 1282 00:54:50,570 --> 00:54:54,140 people will be overwhelmed there were 1283 00:54:52,550 --> 00:54:57,020 questions about speed of what we had to 1284 00:54:54,140 --> 00:54:59,450 do this I said before the part of the 1285 00:54:57,020 --> 00:55:01,190 reason for that was simply the nature of 1286 00:54:59,450 --> 00:55:03,920 what we have to do in the context of NIH 1287 00:55:01,190 --> 00:55:05,900 I'd like to also point out that we are 1288 00:55:03,920 --> 00:55:09,080 also working very quickly and are 1289 00:55:05,900 --> 00:55:12,350 somewhat overwhelmed with the work that 1290 00:55:09,080 --> 00:55:13,970 we're doing here yes this is fast but 1291 00:55:12,350 --> 00:55:16,490 I'd like to also point out that the 1292 00:55:13,970 --> 00:55:19,010 nature of an OT is this is a starting 1293 00:55:16,490 --> 00:55:20,600 point we can extend things in OTS we can 1294 00:55:19,010 --> 00:55:22,850 add things in OTS 1295 00:55:20,600 --> 00:55:25,220 so as we move along and understanding 1296 00:55:22,850 --> 00:55:27,650 our prototypes and understanding the 1297 00:55:25,220 --> 00:55:29,120 plans should we feel that there's a need 1298 00:55:27,650 --> 00:55:32,450 for additional technologies 1299 00:55:29,120 --> 00:55:35,270 understanding etc the OT provides us our 1300 00:55:32,450 --> 00:55:36,800 cover our rich able to add additional 1301 00:55:35,270 --> 00:55:39,560 components should we actually need that 1302 00:55:36,800 --> 00:55:43,190 that is exciting way that certainly 1303 00:55:39,560 --> 00:55:45,590 grants operate it's extremely long time 1304 00:55:43,190 --> 00:55:47,360 consuming and difficult you do 1305 00:55:45,590 --> 00:55:53,270 supplements and the committee's given 1306 00:55:47,360 --> 00:55:58,670 your very good limited memory I plead me 1307 00:55:53,270 --> 00:55:59,750 okay we will be here thanks the 1308 00:55:58,670 --> 00:56:01,820 point I'm trying to make here is that 1309 00:55:59,750 --> 00:56:03,770 although this is a fast turnaround and 1310 00:56:01,820 --> 00:56:05,330 we appreciate that it's fast for all of 1311 00:56:03,770 --> 00:56:08,180 us and we're trying to do the best we 1312 00:56:05,330 --> 00:56:09,770 can on the plus side Francis Collins and 1313 00:56:08,180 --> 00:56:11,450 the rest of the ic directors feel 1314 00:56:09,770 --> 00:56:13,820 very strongly about this project and we 1315 00:56:11,450 --> 00:56:16,220 have support from in my time at NIH I 1316 00:56:13,820 --> 00:56:18,290 don't think I've seen Francis read the 1317 00:56:16,220 --> 00:56:20,720 detail he's spent with looking at this 1318 00:56:18,290 --> 00:56:22,640 fo a or this roll out my apology and 1319 00:56:20,720 --> 00:56:23,840 that shows I think the level of 1320 00:56:22,640 --> 00:56:25,850 commitment that our leadership is 1321 00:56:23,840 --> 00:56:28,190 putting towards this having said that 1322 00:56:25,850 --> 00:56:31,640 and we're all rushing towards this as we 1323 00:56:28,190 --> 00:56:33,200 enter stage one there we expect to be 1324 00:56:31,640 --> 00:56:34,140 able to think about what additional 1325 00:56:33,200 --> 00:56:36,900 things we might 1326 00:56:34,140 --> 00:56:39,359 and why and bring those in as 1327 00:56:36,900 --> 00:56:41,549 appropriate for those so we do expect to 1328 00:56:39,359 --> 00:56:44,760 see additional opportunities not like a 1329 00:56:41,549 --> 00:56:47,329 usual grant or some contracts which is 1330 00:56:44,760 --> 00:56:49,980 often limited only to that particular 1331 00:56:47,329 --> 00:56:51,390 funding announcement I don't know if you 1332 00:56:49,980 --> 00:56:53,970 guys want to adjust as anything yeah 1333 00:56:51,390 --> 00:56:57,210 this is just later faculty a follow on 1334 00:56:53,970 --> 00:56:59,400 that absolutely for ot everything is 1335 00:56:57,210 --> 00:57:00,930 essentially subject to renegotiation so 1336 00:56:59,400 --> 00:57:02,549 if we get into something and we see that 1337 00:57:00,930 --> 00:57:03,660 there's a component we need to add or 1338 00:57:02,549 --> 00:57:05,730 there's something we need to subtract 1339 00:57:03,660 --> 00:57:07,859 you know we would come to you and 1340 00:57:05,730 --> 00:57:09,809 propose that we negotiate that so a 1341 00:57:07,859 --> 00:57:13,130 bandwidth ot it's very very different 1342 00:57:09,809 --> 00:57:16,010 nothing is set in stone you know it's a 1343 00:57:13,130 --> 00:57:18,450 collaborative negotiated arrangement 1344 00:57:16,010 --> 00:57:21,150 this is pleasant there was a question 1345 00:57:18,450 --> 00:57:24,660 about curating the pilots the datasets 1346 00:57:21,150 --> 00:57:28,430 that go into the pilot Commons and that 1347 00:57:24,660 --> 00:57:32,279 will be done in conjunction with the 1348 00:57:28,430 --> 00:57:35,670 coordinators at each of the for each of 1349 00:57:32,279 --> 00:57:37,260 the projects each of the program we 1350 00:57:35,670 --> 00:57:39,960 handled a lot about DB Gaps please 1351 00:57:37,260 --> 00:57:41,490 don't scold my armor this EB guess 1352 00:57:39,960 --> 00:57:43,740 building allow redistribution of their 1353 00:57:41,490 --> 00:57:45,450 data we didn't get data from yet how do 1354 00:57:43,740 --> 00:57:47,279 we deal with that in context we're aware 1355 00:57:45,450 --> 00:57:49,769 of that part of what we're trying to do 1356 00:57:47,279 --> 00:57:51,750 here is realize that a lot of the data 1357 00:57:49,769 --> 00:57:54,930 which sits inside DB gap is actually 1358 00:57:51,750 --> 00:57:57,059 needed in these environments there are I 1359 00:57:54,930 --> 00:57:58,740 was involved along with M CDI and a 1360 00:57:57,059 --> 00:58:01,799 number of folks at NIH helping and 1361 00:57:58,740 --> 00:58:03,539 changing the position statements to the 1362 00:58:01,799 --> 00:58:05,789 youth DB gap data in the cloud 1363 00:58:03,539 --> 00:58:07,589 there are notice points within our 1364 00:58:05,789 --> 00:58:10,109 solicitation that cover this and we're 1365 00:58:07,589 --> 00:58:11,549 fully aware of it I've been doing myself 1366 00:58:10,109 --> 00:58:12,960 in a number of the ten here have been 1367 00:58:11,549 --> 00:58:15,269 working very closely with Patti Brennan 1368 00:58:12,960 --> 00:58:23,250 and also NCBI to figure out what the 1369 00:58:15,269 --> 00:58:27,539 right way to work those groups are the 1370 00:58:23,250 --> 00:58:28,500 DVDs that are available and what is the 1371 00:58:27,539 --> 00:58:30,930 right authentication authorization 1372 00:58:28,500 --> 00:58:33,569 protocols required for that to actually 1373 00:58:30,930 --> 00:58:35,609 happen we're aware of those things and 1374 00:58:33,569 --> 00:58:37,380 we're working through those but we still 1375 00:58:35,609 --> 00:58:39,180 expect this data to be made available in 1376 00:58:37,380 --> 00:58:40,680 those environments so it's not a case 1377 00:58:39,180 --> 00:58:42,119 that it's going to hinder us we're 1378 00:58:40,680 --> 00:58:44,190 working with those groups to actively 1379 00:58:42,119 --> 00:58:46,470 change and to figure out how to do that 1380 00:58:44,190 --> 00:58:47,770 if we don't then I don't think we've 1381 00:58:46,470 --> 00:58:49,480 achieved what we need to do in the 1382 00:58:47,770 --> 00:58:51,940 data Commons which has really changed 1383 00:58:49,480 --> 00:58:54,040 the way we're handling large complex 1384 00:58:51,940 --> 00:58:56,110 data and making it accessible and usable 1385 00:58:54,040 --> 00:58:57,670 to a broader community that can either 1386 00:58:56,110 --> 00:58:59,290 user themselves or develop their own 1387 00:58:57,670 --> 00:59:02,260 tools and systems overtop of it 1388 00:58:59,290 --> 00:59:05,230 there's a question about the term 1389 00:59:02,260 --> 00:59:08,770 consortium and the way that we're using 1390 00:59:05,230 --> 00:59:11,590 it is a little of an overloaded to all 1391 00:59:08,770 --> 00:59:13,780 of the groups of people that are going 1392 00:59:11,590 --> 00:59:17,020 to be working on this will come together 1393 00:59:13,780 --> 00:59:18,970 with NIH staff to form the data Commons 1394 00:59:17,020 --> 00:59:22,570 pilot consortium that will include 1395 00:59:18,970 --> 00:59:25,930 investigators from top made GPX and the 1396 00:59:22,570 --> 00:59:28,870 model organism databases you are welcome 1397 00:59:25,930 --> 00:59:34,450 to submit a team or consortium in 1398 00:59:28,870 --> 00:59:36,100 response to this solicitation you can 1399 00:59:34,450 --> 00:59:39,390 bring together whatever expertise you 1400 00:59:36,100 --> 00:59:42,340 need across academia nonprofits 1401 00:59:39,390 --> 00:59:44,470 for-profits whatever it is you believe 1402 00:59:42,340 --> 00:59:46,390 that needs to be done as a team which we 1403 00:59:44,470 --> 00:59:51,880 are also calling a consortium because 1404 00:59:46,390 --> 00:59:54,250 that's not confusing right this is 1405 00:59:51,880 --> 00:59:56,410 actually an opportunity to kind of think 1406 00:59:54,250 --> 00:59:58,990 about how we do business in a creative 1407 00:59:56,410 --> 01:00:01,840 manner we need to get away from our 1408 00:59:58,990 --> 01:00:03,670 traditional ways of doing grants and 1409 01:00:01,840 --> 01:00:05,590 contracts and we're reaching out to you 1410 01:00:03,670 --> 01:00:07,380 all to help inform us on how to move 1411 01:00:05,590 --> 01:00:09,940 forward 1412 01:00:07,380 --> 01:00:12,490 there's also another words you know I 1413 01:00:09,940 --> 01:00:13,720 noticed with your confusion fast etc for 1414 01:00:12,490 --> 01:00:15,100 all the reasons I mentioned before I 1415 01:00:13,720 --> 01:00:16,990 hope that I've tried to explain we're 1416 01:00:15,100 --> 01:00:18,940 all in the same boat but we want to keep 1417 01:00:16,990 --> 01:00:20,170 openness as an important standard both 1418 01:00:18,940 --> 01:00:22,690 in what we developed for this project 1419 01:00:20,170 --> 01:00:24,570 and also how we communicate so we have 1420 01:00:22,690 --> 01:00:26,800 an awesome communication team here and 1421 01:00:24,570 --> 01:00:28,840 they've done a fabulous job of getting 1422 01:00:26,800 --> 01:00:31,210 out all these announcements and getting 1423 01:00:28,840 --> 01:00:32,800 us up and running today we've had a lot 1424 01:00:31,210 --> 01:00:34,330 of discussions around what's the right 1425 01:00:32,800 --> 01:00:35,770 way that we can communicate with the 1426 01:00:34,330 --> 01:00:38,380 community in future about what's 1427 01:00:35,770 --> 01:00:40,930 happening with this pilot so there's you 1428 01:00:38,380 --> 01:00:42,160 know the community is aware of it if you 1429 01:00:40,930 --> 01:00:43,600 were seeing something that's really 1430 01:00:42,160 --> 01:00:45,220 valuable that you think is really 1431 01:00:43,600 --> 01:00:48,220 important that there's a way for you to 1432 01:00:45,220 --> 01:00:50,290 contribute ideas or thoughts so that it 1433 01:00:48,220 --> 01:00:51,580 is not a closed system and it's not our 1434 01:00:50,290 --> 01:00:53,050 intention here I think if you're going 1435 01:00:51,580 --> 01:00:54,570 to develop something open we also have 1436 01:00:53,050 --> 01:00:57,130 to be open about the way we communicate 1437 01:00:54,570 --> 01:00:59,680 the tunica pact communication sign is 1438 01:00:57,130 --> 01:01:00,580 not I don't think it's followed I think 1439 01:00:59,680 --> 01:01:01,960 we're just working 1440 01:01:00,580 --> 01:01:03,760 those pieces but we're definitely open 1441 01:01:01,960 --> 01:01:05,560 to hearing communication and concepts 1442 01:01:03,760 --> 01:01:09,760 from the community of how to how do we 1443 01:01:05,560 --> 01:01:12,100 unconverted what we're doing and how do 1444 01:01:09,760 --> 01:01:18,760 we keep you engaged with other places to 1445 01:01:12,100 --> 01:01:21,160 engage with so I could possibly speak 1446 01:01:18,760 --> 01:01:24,520 quickly to the minimal minimal Viable 1447 01:01:21,160 --> 01:01:29,020 Product question so the idea of user 1448 01:01:24,520 --> 01:01:31,780 cases was originally to have an idea of 1449 01:01:29,020 --> 01:01:34,840 how to integrate different rmx layers 1450 01:01:31,780 --> 01:01:37,630 for example and with a minimal Viable 1451 01:01:34,840 --> 01:01:41,650 Product one possible way of seeing that 1452 01:01:37,630 --> 01:01:44,050 is that a user case can be presented 1453 01:01:41,650 --> 01:01:46,990 with limited amounts of data and little 1454 01:01:44,050 --> 01:01:49,900 amounts of underlying technology and so 1455 01:01:46,990 --> 01:01:53,560 that thin slice through that user case 1456 01:01:49,900 --> 01:01:56,650 type analysis is that a middle viable 1457 01:01:53,560 --> 01:01:59,710 product was to basically represent on a 1458 01:01:56,650 --> 01:02:01,450 small scale what what the analysis 1459 01:01:59,710 --> 01:02:05,160 result would be for minimal Viable 1460 01:02:01,450 --> 01:02:08,140 Product and so the underlying 1461 01:02:05,160 --> 01:02:10,150 standardization with data carbons be 1462 01:02:08,140 --> 01:02:16,180 that would be this challenge to have 1463 01:02:10,150 --> 01:02:17,890 that in that new viable product I'm 1464 01:02:16,180 --> 01:02:20,740 sorry my name is Martin leer cos I've 1465 01:02:17,890 --> 01:02:24,730 been involved with the data Commons 1466 01:02:20,740 --> 01:02:27,010 pilot also and I'm at the NHLBI in a 1467 01:02:24,730 --> 01:02:32,770 capacity of project scientist for 1468 01:02:27,010 --> 01:02:35,380 bioinformatics apparently a recurring 1469 01:02:32,770 --> 01:02:39,520 question is just how are we going to say 1470 01:02:35,380 --> 01:02:44,280 yes so visit Murray again in respect to 1471 01:02:39,520 --> 01:02:44,280 the question of will otherwise be 1472 01:02:45,330 --> 01:02:54,790 reviewed in whole or by key capability I 1473 01:02:49,680 --> 01:02:59,100 wouldn't like to create zoom the results 1474 01:02:54,790 --> 01:03:02,380 of the review I would add that the 1475 01:02:59,100 --> 01:03:05,560 announcement is very clear that the 1476 01:03:02,380 --> 01:03:10,570 intent is to apply for more than one key 1477 01:03:05,560 --> 01:03:12,280 capability we actually provide space for 1478 01:03:10,570 --> 01:03:15,040 how 1479 01:03:12,280 --> 01:03:19,510 you intend for these objectives to 1480 01:03:15,040 --> 01:03:22,720 interact I think that if you do that 1481 01:03:19,510 --> 01:03:26,140 then it will be that will be seriously 1482 01:03:22,720 --> 01:03:27,790 looked at so I wouldn't like to presume 1483 01:03:26,140 --> 01:03:31,450 what the effects of the review is 1484 01:03:27,790 --> 01:03:40,450 bearing in mind that OTS are a very 1485 01:03:31,450 --> 01:03:42,730 flexible mechanism the important time at 1486 01:03:40,450 --> 01:03:44,590 NIH where the community has to work as a 1487 01:03:42,730 --> 01:03:46,300 team and the timeline is not supposed to 1488 01:03:44,590 --> 01:03:47,710 happen I see where you're coming from 1489 01:03:46,300 --> 01:03:49,390 I'm just going to reiterate what I said 1490 01:03:47,710 --> 01:03:53,080 before we're both having to work fast 1491 01:03:49,390 --> 01:03:54,460 you and us fortunate that I've been 1492 01:03:53,080 --> 01:03:57,130 mentioned before this is just the 1493 01:03:54,460 --> 01:04:01,060 starting point we're trying to do this 1494 01:03:57,130 --> 01:04:02,680 again as a community of people and we 1495 01:04:01,060 --> 01:04:05,350 would do it not prescribing how to do 1496 01:04:02,680 --> 01:04:08,350 that so the first step is really simply 1497 01:04:05,350 --> 01:04:10,690 a point and that is going to 1498 01:04:08,350 --> 01:04:12,550 give us 180 days to go timeline of what 1499 01:04:10,690 --> 01:04:13,780 we actually build and we'd be open about 1500 01:04:12,550 --> 01:04:14,980 that you're not going to suddenly find 1501 01:04:13,780 --> 01:04:16,780 out additives at the end of the hundred 1502 01:04:14,980 --> 01:04:18,310 eighty days we want to be clear about 1503 01:04:16,780 --> 01:04:20,050 what it is we're developing as we go 1504 01:04:18,310 --> 01:04:24,880 along because we do want to include the 1505 01:04:20,050 --> 01:04:26,530 community this question is there a is 1506 01:04:24,880 --> 01:04:27,880 as a stage one 1507 01:04:26,530 --> 01:04:30,640 applicant my company could make a 1508 01:04:27,880 --> 01:04:31,630 proposal and work in isolation is funded 1509 01:04:30,640 --> 01:04:34,390 except for group 1510 01:04:31,630 --> 01:04:36,130 the obligate meetings or is the case of 1511 01:04:34,390 --> 01:04:37,270 mine stage one project is funded will be 1512 01:04:36,130 --> 01:04:38,740 folded in with other collaborative 1513 01:04:37,270 --> 01:04:44,170 projects to entertain a collaborative 1514 01:04:38,740 --> 01:04:46,120 consortium but this is comedies we 1515 01:04:44,170 --> 01:04:47,620 understand that you have certain 1516 01:04:46,120 --> 01:04:50,440 proprietary and things that you wanted 1517 01:04:47,620 --> 01:04:52,480 to do but this is all about creating the 1518 01:04:50,440 --> 01:04:54,790 right instance to the person who has a 1519 01:04:52,480 --> 01:04:57,040 previous statement we want to create a 1520 01:04:54,790 --> 01:04:58,300 team and I recognize that complicated 1521 01:04:57,040 --> 01:05:00,760 when you're dealing with commercial 1522 01:04:58,300 --> 01:05:02,770 interests I think we also have plenty of 1523 01:05:00,760 --> 01:05:05,110 examples with Commission list we work 1524 01:05:02,770 --> 01:05:08,230 well with academia and we're looking for 1525 01:05:05,110 --> 01:05:09,760 ways to learn from our past and also 1526 01:05:08,230 --> 01:05:12,310 from some of our colleagues in the 1527 01:05:09,760 --> 01:05:13,930 commercial field to help us better 1528 01:05:12,310 --> 01:05:16,080 understand how we could work with you as 1529 01:05:13,930 --> 01:05:18,280 well we've been a couple of questions 1530 01:05:16,080 --> 01:05:20,320 regarding whether additional partners 1531 01:05:18,280 --> 01:05:22,900 can be added to the proposal after the 1532 01:05:20,320 --> 01:05:25,540 letter of intent is submitted the answer 1533 01:05:22,900 --> 01:05:26,180 is yes however your letter of intent 1534 01:05:25,540 --> 01:05:29,990 must 1535 01:05:26,180 --> 01:05:33,080 demonstrate a team or an organization 1536 01:05:29,990 --> 01:05:36,890 that is capable of meeting the key goals 1537 01:05:33,080 --> 01:05:39,500 that you are submitting against you can 1538 01:05:36,890 --> 01:05:43,190 come in with others to bolster that in 1539 01:05:39,500 --> 01:05:44,510 your proposal but you have to 1540 01:05:43,190 --> 01:05:45,980 demonstrate in your letter of intent 1541 01:05:44,510 --> 01:05:49,100 that you are capable of doing it with 1542 01:05:45,980 --> 01:05:52,490 the people you have there's a question 1543 01:05:49,100 --> 01:05:54,950 about the expected involvement our 1544 01:05:52,490 --> 01:05:57,020 research program through this funding 1545 01:05:54,950 --> 01:06:12,500 mechanism intramural investigators are 1546 01:05:57,020 --> 01:06:15,260 not allowed to apply research we know we 1547 01:06:12,500 --> 01:06:16,790 have to have written studies and we're 1548 01:06:15,260 --> 01:06:23,180 keeping that aligned but we know that 1549 01:06:16,790 --> 01:06:27,410 there's a need internally I'm just 1550 01:06:23,180 --> 01:06:30,050 looking on the question to anyone I do 1551 01:06:27,410 --> 01:06:32,360 have a question but can can you speak to 1552 01:06:30,050 --> 01:06:39,110 whether or not there is a particular 1553 01:06:32,360 --> 01:06:41,840 desire to see applicants submit in a 1554 01:06:39,110 --> 01:06:46,040 collaborative capacity or would there be 1555 01:06:41,840 --> 01:06:48,020 a bias against say an applicant who felt 1556 01:06:46,040 --> 01:06:53,360 that they could satisfy all the key 1557 01:06:48,020 --> 01:06:54,860 capabilities there is no bias I would 1558 01:06:53,360 --> 01:06:57,110 only say that if you want to come in and 1559 01:06:54,860 --> 01:06:58,610 do all of the capabilities and simply 1560 01:06:57,110 --> 01:07:00,740 think that you can do all of that you 1561 01:06:58,610 --> 01:07:03,530 better be able to justify it very well 1562 01:07:00,740 --> 01:07:04,820 that's one and two how are you going to 1563 01:07:03,530 --> 01:07:05,930 collaborate with other people that are 1564 01:07:04,820 --> 01:07:07,130 going to need to be able to enter 1565 01:07:05,930 --> 01:07:08,900 operate with the systems that you're 1566 01:07:07,130 --> 01:07:10,910 suggesting this is not a closed system 1567 01:07:08,900 --> 01:07:12,530 even if you come in as a quote 1568 01:07:10,910 --> 01:07:16,130 consortium of collection of people of 1569 01:07:12,530 --> 01:07:17,630 academia and commercial we want to see 1570 01:07:16,130 --> 01:07:21,260 how you're reaching out to the community 1571 01:07:17,630 --> 01:07:24,850 as well with your system I think that's 1572 01:07:21,260 --> 01:07:24,850 anyone else want anything sir 1573 01:07:26,309 --> 01:07:30,910 thank you 1574 01:07:29,440 --> 01:07:32,410 we're still working through summers 1575 01:07:30,910 --> 01:07:33,940 we've got through many of the chat boxes 1576 01:07:32,410 --> 01:07:36,880 on looking back now some of the 1577 01:07:33,940 --> 01:07:38,230 documents that have come in before so if 1578 01:07:36,880 --> 01:07:40,000 there's a bit of silence it's 1579 01:07:38,230 --> 01:07:51,630 just we're trying to ascertain the 1580 01:07:40,000 --> 01:07:51,630 question well question to answer 1581 01:07:59,410 --> 01:08:03,980 question here about again about budgets 1582 01:08:02,150 --> 01:08:05,600 should budgets include any estimates for 1583 01:08:03,980 --> 01:08:07,850 work to be performed after the first 1584 01:08:05,600 --> 01:08:09,620 hundred eighty days I think we should 1585 01:08:07,850 --> 01:08:11,450 just look at the first budget period of 1586 01:08:09,620 --> 01:08:13,850 time because quite frankly stage two 1587 01:08:11,450 --> 01:08:15,470 will likely be fiction and we just want 1588 01:08:13,850 --> 01:08:17,060 to be realistic as much as we've asked 1589 01:08:15,470 --> 01:08:18,980 you to base it in reality we want to 1590 01:08:17,060 --> 01:08:21,830 keep it in reality as well so we want to 1591 01:08:18,980 --> 01:08:26,450 look at state level I would also remind 1592 01:08:21,830 --> 01:08:28,460 everyone that in stage two for moving to 1593 01:08:26,450 --> 01:08:31,640 stage two we are going to be asking 1594 01:08:28,460 --> 01:08:33,730 again for a budget report everyone needs 1595 01:08:31,640 --> 01:08:37,580 to understand that this is not a 1596 01:08:33,730 --> 01:08:40,760 stagnant type of mechanism that it will 1597 01:08:37,580 --> 01:08:43,460 be negotiated as the as more information 1598 01:08:40,760 --> 01:08:45,470 becomes available and as we identify the 1599 01:08:43,460 --> 01:08:48,260 capabilities of the partners working 1600 01:08:45,470 --> 01:08:50,330 together so we may be in a situation of 1601 01:08:48,260 --> 01:08:59,210 continuous negotiation depending on 1602 01:08:50,330 --> 01:09:00,830 what's going on good question here is 1603 01:08:59,210 --> 01:09:02,150 when fashioning a project team should 1604 01:09:00,830 --> 01:09:04,340 technology developers seek out 1605 01:09:02,150 --> 01:09:06,650 scientists to use who might use these 1606 01:09:04,340 --> 01:09:10,250 technologies that's dependent upon what 1607 01:09:06,650 --> 01:09:12,290 you want to answer if it's looking at 1608 01:09:10,250 --> 01:09:14,900 the low level from the IT infrastructure 1609 01:09:12,290 --> 01:09:17,870 it's obviously not necessarily directly 1610 01:09:14,900 --> 01:09:20,120 related to the use case but if it speeds 1611 01:09:17,870 --> 01:09:21,500 it up it allows a user to access a lot 1612 01:09:20,120 --> 01:09:23,120 of data very quickly and it's 1613 01:09:21,500 --> 01:09:25,100 cost-efficient both in times and 1614 01:09:23,120 --> 01:09:27,080 potentially dollars that's a direct 1615 01:09:25,100 --> 01:09:29,060 connection to the ability to do science 1616 01:09:27,080 --> 01:09:30,859 even though it may not address our you 1617 01:09:29,060 --> 01:09:32,660 interior disease but I think it's 1618 01:09:30,859 --> 01:09:34,670 relevant in this case and it touches on 1619 01:09:32,660 --> 01:09:37,490 the fact that this is both an equivalent 1620 01:09:34,670 --> 01:09:39,109 service technology and biomedical we're 1621 01:09:37,490 --> 01:09:41,780 trying to fuse those two things together 1622 01:09:39,109 --> 01:09:43,340 so both have equivalences so you don't 1623 01:09:41,780 --> 01:09:44,750 necessarily need to have a scientist it 1624 01:09:43,340 --> 01:09:46,900 would help you if a scientist tells you 1625 01:09:44,750 --> 01:09:49,340 hey this would be faster if I could do X 1626 01:09:46,900 --> 01:09:51,350 but it's not a requirement for you to do 1627 01:09:49,340 --> 01:09:52,330 that again it's how do you address the 1628 01:09:51,350 --> 01:09:58,220 components of what disability 1629 01:09:52,330 --> 01:10:00,250 solicitation is asking you so I just 1630 01:09:58,220 --> 01:10:03,830 wanted to answer a good question again 1631 01:10:00,250 --> 01:10:06,530 about whether or not otherwise will be 1632 01:10:03,830 --> 01:10:08,930 considered in their entirety or her key 1633 01:10:06,530 --> 01:10:09,680 capability that's being proposed to be 1634 01:10:08,930 --> 01:10:12,600 addressed 1635 01:10:09,680 --> 01:10:16,050 by pointing out that 1636 01:10:12,600 --> 01:10:20,070 there is a specific space various space 1637 01:10:16,050 --> 01:10:22,730 allocated in the law if the intent is to 1638 01:10:20,070 --> 01:10:27,270 address more than one key capability 1639 01:10:22,730 --> 01:10:31,530 that I think will will be considered 1640 01:10:27,270 --> 01:10:36,210 quite seriously by the review panel I 1641 01:10:31,530 --> 01:10:39,989 cannot at this moment presume what the 1642 01:10:36,210 --> 01:10:41,880 results of the review will be I would 1643 01:10:39,989 --> 01:10:44,370 only point out that there is space to 1644 01:10:41,880 --> 01:10:49,710 make such a justification and that this 1645 01:10:44,370 --> 01:10:51,540 is meant to be a flexible meknes another 1646 01:10:49,710 --> 01:10:53,429 question came in should applicants 1647 01:10:51,540 --> 01:10:55,679 attempt to link their proposals to other 1648 01:10:53,429 --> 01:10:57,719 proposals will it strengthen their 1649 01:10:55,679 --> 01:10:59,820 proposal to note synergies between two 1650 01:10:57,719 --> 01:11:02,460 proposals submitted by two different pis 1651 01:10:59,820 --> 01:11:04,679 I think that's a very important question 1652 01:11:02,460 --> 01:11:05,969 to ask considering that the 1653 01:11:04,679 --> 01:11:08,940 collaboration that's going to be 1654 01:11:05,969 --> 01:11:11,610 required of a nimble team to accomplish 1655 01:11:08,940 --> 01:11:15,260 a goal I didn't know if anybody else 1656 01:11:11,610 --> 01:11:15,260 want to jump in comment to that 1657 01:11:23,610 --> 01:11:32,440 okay I just wanted to clarify a budget 1658 01:11:28,690 --> 01:11:34,360 is requested for stage one you shouldn't 1659 01:11:32,440 --> 01:11:37,810 submit a budget for the entire four 1660 01:11:34,360 --> 01:11:49,900 years but a budget is required for stage 1661 01:11:37,810 --> 01:11:53,020 one so there's another question about 1662 01:11:49,900 --> 01:11:56,170 FWA and IRB will it be required to 1663 01:11:53,020 --> 01:11:57,940 operate the data Commons pilot and our 1664 01:11:56,170 --> 01:12:01,469 understanding is that the human data is 1665 01:11:57,940 --> 01:12:07,360 be identified which would not required 1666 01:12:01,469 --> 01:12:11,949 and there's statements at NCI CGC pilots 1667 01:12:07,360 --> 01:12:14,290 and TCGA DCC and target DCC did not have 1668 01:12:11,949 --> 01:12:17,079 one this will be something that we will 1669 01:12:14,290 --> 01:12:20,739 iron out in negotiations as we move a 1670 01:12:17,079 --> 01:12:24,880 little bit on who is offered to 1671 01:12:20,739 --> 01:12:26,889 participate under this program so the 1672 01:12:24,880 --> 01:12:30,250 question there got changed sighs there 1673 01:12:26,889 --> 01:12:34,449 is a very significant solid a push from 1674 01:12:30,250 --> 01:12:37,150 NHLBI one of the data sets in particular 1675 01:12:34,449 --> 01:12:41,800 that will be available for pilots that 1676 01:12:37,150 --> 01:12:44,500 he does require IRB approval its ring of 1677 01:12:41,800 --> 01:12:46,800 it we don't want to presume we know 1678 01:12:44,500 --> 01:12:50,260 who's coming in with what with 1679 01:12:46,800 --> 01:12:52,300 collaboration and so generically that is 1680 01:12:50,260 --> 01:12:56,050 something that we would do at the time 1681 01:12:52,300 --> 01:12:57,790 of award but your point is we'll take in 1682 01:12:56,050 --> 01:13:03,400 Kashan thank you very much for for 1683 01:12:57,790 --> 01:13:05,679 letting us know okay I think we've 1684 01:13:03,400 --> 01:13:07,810 almost got to the end of the questions 1685 01:13:05,679 --> 01:13:14,260 is that so I've been running through 1686 01:13:07,810 --> 01:13:19,270 those you guys as well hold on oh I get 1687 01:13:14,260 --> 01:13:21,070 so page one okay so another question 1688 01:13:19,270 --> 01:13:23,739 came in about the budget of whether 1689 01:13:21,070 --> 01:13:25,570 stage one should you include just stage 1690 01:13:23,739 --> 01:13:29,099 one for the first hundred eighty days or 1691 01:13:25,570 --> 01:13:32,230 should you include after been Phase two 1692 01:13:29,099 --> 01:13:34,599 you know we're really interested in the 1693 01:13:32,230 --> 01:13:36,849 hundred and eighty day pilot period if 1694 01:13:34,599 --> 01:13:39,999 you were to include a dish 1695 01:13:36,849 --> 01:13:42,880 you know it's going to be it's just a 1696 01:13:39,999 --> 01:13:45,219 placeholder it's not going to be fully 1697 01:13:42,880 --> 01:13:47,170 vetted until we move to that phase and 1698 01:13:45,219 --> 01:13:51,940 we actually enter into negotiation if 1699 01:13:47,170 --> 01:13:54,340 you're selected to participate and when 1700 01:13:51,940 --> 01:13:56,709 I started answering before with team 1701 01:13:54,340 --> 01:13:58,449 size there is no limit for maximum again 1702 01:13:56,709 --> 01:14:00,219 it's relative to what you think is 1703 01:13:58,449 --> 01:14:01,889 appropriate for the project to 1704 01:14:00,219 --> 01:14:04,269 accomplish what you need to get done 1705 01:14:01,889 --> 01:14:06,249 remember in a team environment you have 1706 01:14:04,269 --> 01:14:09,070 to have a lead who is going to kind of 1707 01:14:06,249 --> 01:14:11,229 represent that collective with the 1708 01:14:09,070 --> 01:14:12,729 government that all of you all have to 1709 01:14:11,229 --> 01:14:14,769 have an agreement amongst yourself on 1710 01:14:12,729 --> 01:14:20,949 how you're going to operate because we 1711 01:14:14,769 --> 01:14:23,469 will not broker that deal for you okay 1712 01:14:20,949 --> 01:14:24,639 we've gone through almost all of the 1713 01:14:23,469 --> 01:14:32,889 questions I think we've got on to the 1714 01:14:24,639 --> 01:14:34,059 chat box but all right so the last 1715 01:14:32,889 --> 01:14:36,519 question one of the questions that came 1716 01:14:34,059 --> 01:14:38,199 in was what are your expectations on how 1717 01:14:36,519 --> 01:14:39,519 the artifacts after three to four years 1718 01:14:38,199 --> 01:14:44,019 of this OT will interact with the 1719 01:14:39,519 --> 01:14:45,820 ncip these like the GDC VGC so we've had 1720 01:14:44,019 --> 01:14:48,809 a lot of conversations with folks 1721 01:14:45,820 --> 01:14:50,769 internally at NIH as I mentioned before 1722 01:14:48,809 --> 01:14:52,449 patty Brennan has been excellent in 1723 01:14:50,769 --> 01:14:54,670 working with us and NCBI in figuring out 1724 01:14:52,449 --> 01:14:57,849 how to roll we're aware of those issues 1725 01:14:54,670 --> 01:14:59,800 so are they and there's a spirit of 1726 01:14:57,849 --> 01:15:01,389 collaboration happening there and I'd 1727 01:14:59,800 --> 01:15:03,760 also like to point out that working with 1728 01:15:01,389 --> 01:15:06,510 siding with closely with Warren TV and 1729 01:15:03,760 --> 01:15:08,920 the folks over at NCI and their GDC and 1730 01:15:06,510 --> 01:15:10,959 there are other collaborations around 1731 01:15:08,920 --> 01:15:13,510 the Institute's that are looking at 1732 01:15:10,959 --> 01:15:15,489 these kind of things we fully unwanted 1733 01:15:13,510 --> 01:15:17,619 those there are certainly elements from 1734 01:15:15,489 --> 01:15:20,019 phase 1 as bd2k we want to reuse and 1735 01:15:17,619 --> 01:15:21,789 certainly make available what do we 1736 01:15:20,019 --> 01:15:24,039 expect artifacts after three 1737 01:15:21,789 --> 01:15:26,860 four years part of our goal here is to 1738 01:15:24,039 --> 01:15:29,229 make these large Hisle datasets 1739 01:15:26,860 --> 01:15:30,999 accessible to the community what does it 1740 01:15:29,229 --> 01:15:33,459 take to do that what are the costs 1741 01:15:30,999 --> 01:15:36,010 associated to do that rather than out of 1742 01:15:33,459 --> 01:15:38,139 services on a computational over a 1743 01:15:36,010 --> 01:15:40,209 series of AP is potentially that allow 1744 01:15:38,139 --> 01:15:43,119 you to access it and what are the ways 1745 01:15:40,209 --> 01:15:45,579 that we need that a technology base that 1746 01:15:43,119 --> 01:15:47,530 our support the use of these data sets 1747 01:15:45,579 --> 01:15:48,440 by folks that don't have computational 1748 01:15:47,530 --> 01:15:49,790 backgrounds 1749 01:15:48,440 --> 01:15:51,080 these are all the kinds of things we're 1750 01:15:49,790 --> 01:15:53,690 trying to address in some of these 1751 01:15:51,080 --> 01:16:06,020 pilots and we're expecting it to be one 1752 01:15:53,690 --> 01:16:12,050 step along thank you 1753 01:16:06,020 --> 01:16:13,969 so that's what I would say we were 1754 01:16:12,050 --> 01:16:21,770 challenging their strategic vision to 1755 01:16:13,969 --> 01:16:24,020 accomplish this goal sorry could you the 1756 01:16:21,770 --> 01:16:25,940 second half of your answer to what sort 1757 01:16:24,020 --> 01:16:27,469 of the big picture goal could you repeat 1758 01:16:25,940 --> 01:16:29,210 that agree there was somebody who puts 1759 01:16:27,469 --> 01:16:32,180 the thing on hold and pretty much 1760 01:16:29,210 --> 01:16:35,150 everything you said as sort of the three 1761 01:16:32,180 --> 01:16:41,000 to four years onwards as configurable 1762 01:16:35,150 --> 01:16:43,969 puts in said it was just musics got a 1763 01:16:41,000 --> 01:16:45,980 transmitter over it this is in the 1764 01:16:43,969 --> 01:16:48,890 relation what I just said see if I can 1765 01:16:45,980 --> 01:16:50,270 remember essentially we've done we're 1766 01:16:48,890 --> 01:16:52,640 spending a lot of time collaborating 1767 01:16:50,270 --> 01:16:54,050 across all of NIH and we're all having 1768 01:16:52,640 --> 01:16:56,630 very similar problems across the 1769 01:16:54,050 --> 01:16:58,100 different Institute's we're also 1770 01:16:56,630 --> 01:17:00,920 collaborating with patty Brennan over at 1771 01:16:58,100 --> 01:17:03,199 NLM and NCBI and the goal here is to 1772 01:17:00,920 --> 01:17:05,510 look at how do we address the issues of 1773 01:17:03,199 --> 01:17:07,460 accessibility of data and utility and 1774 01:17:05,510 --> 01:17:08,390 users of these environments because we 1775 01:17:07,460 --> 01:17:11,420 know we're going to have to use some of 1776 01:17:08,390 --> 01:17:13,400 that across all of the Institute's so at 1777 01:17:11,420 --> 01:17:14,960 the end of this we don't want a siloed 1778 01:17:13,400 --> 01:17:16,250 product we want to be able to see how 1779 01:17:14,960 --> 01:17:18,770 does this actually affect the way that 1780 01:17:16,250 --> 01:17:20,989 the different Institute's work and how 1781 01:17:18,770 --> 01:17:22,850 do those pieces enable us to go to the 1782 01:17:20,989 --> 01:17:26,090 next step to maintain the longer-term 1783 01:17:22,850 --> 01:17:27,380 values for this particular project there 1784 01:17:26,090 --> 01:17:28,670 may be things out of this pilot that 1785 01:17:27,380 --> 01:17:30,320 will be shut down because we'll learn 1786 01:17:28,670 --> 01:17:31,699 that we just don't need those or we can 1787 01:17:30,320 --> 01:17:33,770 move from it we know that we need 1788 01:17:31,699 --> 01:17:34,460 something different better going in a 1789 01:17:33,770 --> 01:17:36,920 different direction 1790 01:17:34,460 --> 01:17:40,010 we're also where the technology changes 1791 01:17:36,920 --> 01:17:42,080 very very rapidly so what is valid in 1792 01:17:40,010 --> 01:17:44,239 the next 180 days may be changing over 1793 01:17:42,080 --> 01:17:46,100 time and therefore that is one of the 1794 01:17:44,239 --> 01:17:48,230 reasons to bring folks in with different 1795 01:17:46,100 --> 01:17:49,730 backgrounds that have some of the 1796 01:17:48,230 --> 01:17:51,680 background and the technologies because 1797 01:17:49,730 --> 01:17:54,620 you are working in these fields that are 1798 01:17:51,680 --> 01:17:57,020 rapidly moving so we want to engage with 1799 01:17:54,620 --> 01:17:59,360 you because we also need to offer what 1800 01:17:57,020 --> 01:18:01,219 we do next to be relevant to what it 1801 01:17:59,360 --> 01:18:02,030 already is and where it needs to be 1802 01:18:01,219 --> 01:18:03,260 technologic 1803 01:18:02,030 --> 01:18:05,600 going to be able to address things 1804 01:18:03,260 --> 01:18:07,220 issues not at the end of hydrating days 1805 01:18:05,600 --> 01:18:11,930 address something that we should have 1806 01:18:07,220 --> 01:18:13,550 done 180 days ago that's the side of the 1807 01:18:11,930 --> 01:18:15,110 government is that we are trying to make 1808 01:18:13,550 --> 01:18:16,460 this open and engage the community the 1809 01:18:15,110 --> 01:18:17,780 downside is that sometimes we're a 1810 01:18:16,460 --> 01:18:19,670 little bit behind the curve and some of 1811 01:18:17,780 --> 01:18:20,990 the technologies and in this case what 1812 01:18:19,670 --> 01:18:23,950 we're trying to use the OT is to 1813 01:18:20,990 --> 01:18:32,330 leverage that to go to our future I 1814 01:18:23,950 --> 01:18:33,860 think my music after that maybe yeah so 1815 01:18:32,330 --> 01:18:35,660 I just want to address the question 1816 01:18:33,860 --> 01:18:37,630 about whether or not the LOI and the 1817 01:18:35,660 --> 01:18:41,450 application is only meant to describe 1818 01:18:37,630 --> 01:18:43,130 the first hundred and eighty days we 1819 01:18:41,450 --> 01:18:45,320 would like you to be as specific as 1820 01:18:43,130 --> 01:18:48,350 possible about the activities that you 1821 01:18:45,320 --> 01:18:50,900 climb in the 180 day period but I would 1822 01:18:48,350 --> 01:18:53,570 remind you that the application does ask 1823 01:18:50,900 --> 01:19:05,600 for a vision statement and that is 1824 01:18:53,570 --> 01:19:07,010 clearly longer than 180 days gene do we 1825 01:19:05,600 --> 01:19:08,900 have any other ones that we want to 1826 01:19:07,010 --> 01:19:10,550 something okay 1827 01:19:08,900 --> 01:19:12,260 so we've been scrolling through our chat 1828 01:19:10,550 --> 01:19:13,780 box and I've been going through some of 1829 01:19:12,260 --> 01:19:18,500 the questions that are already posted 1830 01:19:13,780 --> 01:19:19,880 we're working at life speed here so and 1831 01:19:18,500 --> 01:19:21,800 I think people are starting to drop off 1832 01:19:19,880 --> 01:19:23,600 the call so at this point what I would 1833 01:19:21,800 --> 01:19:27,830 say if you have a burning question 1834 01:19:23,600 --> 01:19:30,320 please add it to the chat box now if you 1835 01:19:27,830 --> 01:19:33,260 feel more if you to say something out 1836 01:19:30,320 --> 01:19:36,770 loud do it now and hopefully we'll music 1837 01:19:33,260 --> 01:19:38,240 if we get music but do that now there's 1838 01:19:36,770 --> 01:19:41,170 no need to continue as people have got 1839 01:19:38,240 --> 01:19:41,170 to the end of their question 1840 01:19:46,530 --> 01:19:48,530 Oh 1841 01:19:59,840 --> 01:20:45,060 [Laughter]