| NIH Microphysiological Systems Program: First Investigators’ Meeting |
| 8:00 – 8:30 |
REGISTRATION |
| 8:30 – 8:35 |
Orientation and Goals of the Workshop
Dr. Danilo Tagle |
| 8:35 – 8:45 |
Welcome Remarks
Dr. Kathy Hudson, Acting Deputy Director, National Center for Advancing Translational Sciences (NCATS), NIH |
| 8:45 – 9:00 |
Introductions by Invited Participants |
| 9:00 – 9:20 |
Overview of the NIH Microphysiological Systems Program
Dr. Danilo Tagle, NCATS, NIH |
| 9:20 – 9:30 |
Introduction to DARPA Microphysiological Systems Program and Performers
Dr. Barry Pallotta, DSO, DARPA |
| 9:30 – 9:50 |
DARPA Performers:
Barrier-Immune-Organ: Microphysiology, Microenvironment Engineered Tissue Construct Systems (BIO-MIMETICS)
Dr. Linda Griffith, Massachusetts Institute of Technology |
| 9:50 – 10:10 |
Integrated Human Organ-on-Chip Microphysiological Systems
(Dr. Donald Ingber) and Dr. Daniel Levner, Wyss Institute at Harvard University |
| 10:10 – 10:30 |
BREAK |
| 10:30 – 10:50 |
The FDA and biomarker development and qualification
Dr. Douglas C. Throckmorton, Deputy Director, CDER, FDA |
| 10:50 – 11:10 |
Toxicology in the 21st Century: Tox21 Program and Potential Sources of Validation Compounds
Dr. Raymond Tice, NIEHS, NIH |
| 11:10 – 12:00 |
General Discussion: Process for Communication—semi-annual meetings, conference calls, milestones evaluation, etc. |
| 12:00 – 1:00 |
Lunch (on your own)—Natcher cafeteria
|
Begin Group Presentations: PIs present project overview, scope, specific aims, updates and activities since award, and any foreseen technical and administrative challenges (20-minute overview presentation and updates on each project including discussion). |
U18 Cooperative Agreement Awardees: Cellular resources
Moderator:
Margaret Sutherland, Ph.D., NINDS, NIH |
| 1:00 – 1:20 |
Human intestinal organoids: Pre-clinical models of non-inflammatory diarrhea
Mark Donowitz, M.D., Johns Hopkins University |
| 1:20 – 1:40 |
Modeling oxidative stress and DNA damage using a gastrointestinal organotypic culture system
John P. Lynch, M.D., Ph.D., University of Pennsylvania |
| 1:40 – 2:00 |
Generating human intestinal organoids with an ENS (enteric nervous system)
James M. Wells, Ph.D., Cincinnati Children’s Hospital Medical Center |
| 2:00 – 2:20 |
Three-dimensional human lung model to study lung disease and formation of fibrosis
Joan E. Nichols, Ph.D., The University of Texas Medical Branch at Galveston |
| 2:20 – 2:40 |
A 3-D model of human brain development for studying gene/environment interactions
Thomas Hartung, M.D., Ph.D., Johns Hopkins University |
| 2:40 – 3:00 |
BREAK |
| 3:00 – 3:20 |
Three-dimensional osteochondral micro-tissue to model pathogenesis of osteoarthritis
Rocky S. Tuan, Ph.D., University of Pittsburgh |
| 3:20 – 3:40 |
Modeling complex disease using induced pluripotent stem cell-derived skin constructs
Angela Christiano, Ph.D., Columbia University Health Sciences |
| 3:40 – 4:00 |
General Discussion |
| 4:00 – 5:00 |
Use of Primary, Transformed, Progenitor and Stem Cell Lines: Potential, Challenges and Limitations in Seeding Microphysiological Systems
Moderator: Margaret Sutherland, Ph.D., NINDS, NIH
|
| |
(Meeting adjourns) |
| October 2, 2012 |
UH2 Cooperative Agreement Awardees: Tissues-on-a-chip
Moderator:
Danilo A. Tagle, Ph.D., NCATS, NIH |
| 8:00 – 8:20 |
A tissue-engineered human kidney microphysiological system
Jonathan Himmelfarb, M.D., University of Washington |
| 8:20 – 8:40 |
A 3-D biomimetic liver sinusoid construct for predicting physiology and toxicity
D. Lansing Taylor, Ph.D., University of Pittsburgh |
| 8:40 – 9:00 |
Circulatory system and integrated muscle tissue for drug and tissue toxicity
George A. Truskey, Ph.D., Duke University |
| 9:00 – 9:20 |
Disease-specific integrated microphysiological human tissue models
Kevin E. Healy, Ph.D., University of California, Berkeley |
| 9:20 – 9:40 |
An integrated in vitro model of perfused tumor and cardiac tissue
Steven C. George, M.D., Ph.D., University of California, Irvine |
| 9:40 – 10:00 |
All-human microphysical model of metastasis and therapy
Linda Griffith, Ph.D., Massachusetts Institute of Technology |
| 10:00 – 10:20 |
BREAK |
| 10:20 – 10:40 |
Human cardio-pulmonary system on a chip
(Kevin K. Parker, Ph.D.) and Ashutosh Agarwal, Ph.D., Harvard University |
| 10:40 – 11:00 |
Integrated heart-liver-vascular systems for drug testing in human health and disease
Gordana Vunjak-Novakovic, Ph.D., Columbia University |
| 11:00 – 11:20 |
Ex vivo female reproductive tract integration in a 3-D microphysiologic system
Teresa K. Woodruff, Ph.D., Northwestern University |
| 11:20 – 11:40 |
Microphysiological systems and low cost microfluidic platform with analytics
Michael L. Shuler, Ph.D., Cornell University |
| 11:40 – 12:00 |
Neurovascular unit on a chip: Chemical communication, drug and toxin responses
John P. Wikswo, Ph.D., Vanderbilt University |
| 12:00 – 12:20 |
Human induced pluripotent stem cell and embryonic stem cell-based models for predictive neural toxicity and teratogenicity
James A. Thomson, V.M.D., Ph.D., Morgridge Institute for Research at the University of Wisconsin–Madison |
| 12:20 – 1:20 |
Lunch (on your own)—Natcher cafeteria |
| 1:20 – 3:00 |
Breakout Groups—Grantees, NIH, DARPA and FDA experts associated with each project discuss technical and administrative challenges, needs, collaborations and milestones
Breakout Group 1: Renal and Gastro-intestinal Discussion leaders: Michael Flessner, M.D., NIDDK, NIH and Melanie Blank, M.D., CDER, FDA
Breakout Group 2: Cardio-pulmonary and circulatory Discussion leaders: Martha Lundberg, Ph.D., NHLBI, NIH and Robert Kavlock, Ph.D., NCCT, EPA
Breakout Group 3: Musculoskeletal and integumentary Discussion leaders: Fei Wang, Ph.D., NIAMS, NIH and Abby Jacobs, Ph.D., CDER, FDA
Breakout Group 4: Neurological and other systems Discussion leaders: Rosemarie Hunziker, Ph.D., NIBIB and Jeffrey Bray, Ph.D., CDER, FDA |
| 3:00 – 3:20 |
BREAK |
| 3:20 – 4:00 |
Reports from Breakout Groups (10 minutes each)
Presented by Discussion leaders |
| 4:00 – 5:00 |
General Discussion: Summary and Next Steps
Margaret Sutherland and Danilo A. Tagle |
| |
Closing Remarks |
