Bioinformatics and Computational Biology
- Starve a Yeast, Sweeten Its Lifespan
March 23, 2009
Johns Hopkins researchers have discovered a new energy-making biochemical twist in determining the lifespan of yeast cells, one so valuable to longevity that it is likely to also functions in humans.
Building Blocks, Biological Pathways, and Networks
Epigenomics
NIH Director’s New Innovator Award
- Engineering-systems approach may lead to new cancer treatments
December 4, 2009
In the past year, University of Virginia biomedical engineer Kevin Janes has won $2.6 million in no-strings-attached funding for his innovative research to better understand how cells "make decisions" for good or ill.
- Imaging study shows brain abnormalities in chemotherapy patients
November 11, 2009
Researchers at Stanford University School of Medicine have used neuroimaging to gain insight into a phenomenon known as “chemo brain,” a condition in which cancer patients have difficulty thinking, focusing and remembering.
- New Synthetic Molecules Trigger Immune Response to HIV and Prostate Cancer
November 5, 2009
Researchers at Yale University have developed synthetic molecules capable of enhancing the body’s immune response to HIV and HIV-infected cells, as well as to prostate cancer cells.
- Stretching the Golgi: a link between form and function
October 15, 2009
A research team at the University of California, San Diego School of Medicine has provided a surprisingly simple explanation for the mechanism and features of the “Golgi apparatus”—a structure that has baffled generations of scientists.
- Using Simple Genome, Columbia Researchers Move Personalized Medicine Closer to Reality
October 13, 2009
Researchers at Columbia University have developed a statistical method that accurately predicts how an organism will respond to dozens of commonly used drugs.
- Gene action partially explains treatment success in newborn lungs
September 23, 2009
For more than a decade, obstetrician-gynecologists have given pregnant women facing premature birth steroids to hasten the development of their newborn's lungs. Now a study appearing online in the Proceedings of the National Academy of Sciences involving a "mystery" gene called Erk3 explains the success of that therapy.
- High fat diet in pregnancy changes metabolome of mother, offspring
September 4, 2009
A high fat diet during pregnancy not only results in offspring with fatty livers, but actually changes the small molecules that govern metabolism, said a consortium of researchers led by those from Baylor College of Medicine in a report that appears in the current issue of the American Journal of Obstetrics and Gynecology.
- Large-scale study probes how cells fight pathogens
September 3, 2009
Researchers reconstruct a key molecular circuit in mammalian immune cells; genome-scale methods offer a practical model for future studies.
- Higher drug doses needed to defeat tuberculosis, researchers report
July 30, 2009
The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.
- Stem cells’ “suspended” state preserved by key step, scientists report
July 9, 2009
Scientists have identified a gene that is essential for embryonic stem cells to maintain their all-purpose, pluripotent state.
- Konrad Hochedlinger: A reprogramming revolutionary
July 7, 2009
In 1999, Konrad Hochedlinger squeezed into a packed lecture at the Institute of Molecular Pathology in Vienna to hear stem cell researcher Rudolf Jaenisch talk about nuclear transfer cloning techniques.
- Ed Boyden: The brain engineer
March 3, 2009
At the end of his junior year at the Massachusetts Institute of Technology in 1998, Ed Boyden was hanging out with friends in the basement of the famed Media Lab, trying to figure out what to do for the summer.
- Malaria parasite zeroes in on molecule to enhance its survival, team finds
February 19, 2009
A team of researchers from Princeton University and the Drexel University College of Medicine has found that the parasite that causes malaria breaks down an important amino acid in its quest to adapt and thrive within the human body.
- Penn study finds link between Parkinson's disease genes and manganese poisoning
February 2, 2009
A connection between genetic and environmental causes of Parkinson’s disease has been discovered by a research team led by Aaron D. Gitler, PhD, Assistant Professor in the Department of Cell and Developmental Biology at the University of Pennsylvania School of Medicine.
- Wireless Microgrippers Grab Living Cells in 'Biopsy' Tests
January 12, 2009
Johns Hopkins researchers have invented dust-particle-size devices that can be used to grab and remove living cells from hard-to-reach places without the need for electrical wires, tubes or batteries.
NIH Director’s Pioneer Award Program
- Drug kills cells through novel mechanism
December 10, 2009
MIT and Boston University researchers have discovered that the drug hydroxyurea kills bacteria by inducing them to produce molecules toxic to themselves — a conclusion that raises the possibility of finding new antibiotics that use similar mechanisms.
- Scripps research study describes new tool in the fight against autoimmune diseases, blood cancers
November 30, 2009
Novel approach facilitates identification of molecules that prevent immune cells from attacking the body.
- An exquisite container
November 3, 2009
A tiny cage of gold covered with a smart polymer respond to light, opening to empty its contents.
- Harvard scientists bend nanowires into 2-D and 3-D structures
October 21, 2009
New ‘stereocenters’ introduce triangular joints into otherwise linear nanomaterials
- Large-scale study probes how cells fight pathogens
September 3, 2009
Researchers reconstruct a key molecular circuit in mammalian immune cells; genome-scale methods offer a practical model for future studies.
- Cost of Decoding a Genome Is Lowered
August 11, 2009
A Stanford engineer has invented a new technology for decoding DNA and used it to decode his own genome for less than $50,000.
- UCSB Study Links Strength and Beauty to Anger, Pro-War Attitudes
August 5, 2009
Anthropologists, psychologists, and other experts in human behavior have long recognized anger as a universal emotion.
- Scientists Discover Origin of Malaria (PDF, 2 pages)
August 3, 2009
Discovery Could Lead to Development of New Treatments, Prevent Future Plagues.
- A matter of density, not quantity
July 10, 2009
Individual bacterial cells are capable of quorum sensing when confined in small volumes.
- Research may hold key to maintaining embryonic stem cells in lab
July 9, 2009
In a new study that could transform embryonic stem cell (ES cell) research, scientists at UT Southwestern Medical Center have discovered why mouse ES cells can be easily grown in a laboratory while other mammalian ES cells are difficult, if not impossible, to maintain.
- Microscopic marvels: The naked microscope
June 30, 2009
Sunney Xie's newest microscopes don't look like the latest in sophistication. Tucked away in his biochemistry lab at Harvard University, they seem to be ad hoc assemblies of lasers, objectives and electronics, surrounded by a thicket of optical equipment.
- Trimming The Fat Boosts Blood Recovery After Marrow Transplant
June 17, 2009
Seeking ways to improve blood recovery after chemotherapy or bone marrow transplant, researchers at Children's Hospital Boston have discovered that fat cells, which accumulate in bone marrow as people age, inhibit the marrow's ability to produce new blood cells.
- Stem cell protein offers a new cancer target
May 31, 2009
LIN28, which maintains cell 'stemness,' is abundant in advanced cancers and transforms cells to cancerous state.
- First Detailed Report of New Virus's Promiscuous Past
May 26, 2009
The most detailed description yet of the origins of the novel H1N1 virus causing the swine flu outbreak appears today on ScienceExpress.
- Why do people with Down syndrome have less cancer?
May 20, 2009
Research in mice and human stem cells suggests new therapeutic targets.
- Embryo's Heartbeat Drives Blood Stem Cell Formation
May 13, 2009
Clues about how blood forms could yield new strategies for treating blood diseases.
- Using combinatorial libraries to engineer genetic circuits advances synthetic biology
April 22, 2009
Streamlining the construction of synthetic gene networks has led a team of Boston University researchers to develop a technique that couples libraries of diversified components with computer modeling to guide predictable gene network construction without the back and forth tweaking.
- Study finds blood cells can be reprogrammed to act as embryonic stem cells
April 20, 2009
In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells.
- Penn Scientists Use RNA to Reprogram One Cell Type into Another
April 16, 2009
Implications for Cell-Based Personalized Therapies for Neurodegenerative Diseases.
- Shedding some light on Parkinson's treatment
April 16, 2009
Scientists use optical approach to study deep brain stimulation.
- The games microbes play
April 6, 2009
One of the perplexing questions raised by evolutionary theory is how cooperative behavior, which benefits other members of a species at a cost to the individual, came to exist.
- Sleep: Spring cleaning for the brain?
April 2, 2009
If you've ever been sleep-deprived, you know the feeling that your brain is full of wool.
- Tracking deadly viruses' spread from animals to humans
January 16, 2009
Pandemics can be prevented before they're spread globally, says Dr. Nathan Wolfe.
- Novel technique changes lymph node biopsy, reduces radiation exposure in breast cancer patients
January 13, 2009
Information obtained from a new application of photoacoustic tomography (PAT) is worth its weight in gold to breast cancer patients.
- Synthetic HDL: A new weapon to fight cholesterol problems
January 9, 2009
IButtery Christmas cookies, eggnog, juicy beef roast, rich gravy and creamy New York-style cheesecake. Happy holiday food unfortunately can send blood cholesterol levels sky high.
NIH Director’s T-R01 Award Program
Nanomedicine
- Nanotech Researchers Develop Artificial Pore
September 28, 2009
Using an RNA-powered nanomotor, University of Cincinnati (UC) biomedical engineering researchers have successfully developed an artificial pore able to transmit nanoscale material through a membrane.
- With A Flash Of Light, A Neuron's Function Is Revealed
September 16, 2009
There’s a new way to explore biology’s secrets. With a flash of light, scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory and the University of California, Berkeley zeroed in on the type of neural cell that controls swimming in larval zebrafish.
- UCSF researchers program cells to be remote-controlled by light
September 13, 2009
UCSF researchers have genetically encoded mouse cells to respond to light, creating cells that can be trained to follow a light beam or stop on command like microscopic robots.
Structural Biology
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