| Name of Biobank |
Marshfield Clinic Personalized Medicine Research Project |
| Year Initiated |
2002 |
| Primary objective (one sentence) |
Short-term: to establish a resource to facilitate research in genetic epidemiology, pharmacogenetics and population genetics. Long term: to facilitate the use of genetic markers to personalize health care
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| Key components (please briefly address the following): |
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| Time frame |
Recruitment commenced in 2002 and is ongoing. |
| Sample size (current and anticipated) and characteristics (age, gender) |
Approximately 20,000 adults aged 18+ currently, anticipated 25, 000, 57% female, age range at entry: 18 to 98, median 46.6, 98.2% Caucasian |
| Recruitment area, method of recruitment/follow-up, sample representativeness |
Recruited from 19 zip codes surrounding Marshfield, Wisconsin where greater than 90% of the population seeks their health care through the Marshfield Clinic, representative of central Wisconsin. Potential subjects are sent a letter, followed by a phone call to organize an appointment to enroll. |
| Types of data/specimens collected (questionnaire, physical exam) |
Access to comprehensive electronic medical record (average 30 years of medical history data for enrolled subjects), brief questionnaire with smoking, alcohol, race, ethnicity, family history of common chronic disease, detailed dietary history questionnaire (the National Cancer Institute DHQ), Baecke physical activity questionnaire. Specimens available include: DNA, plasma, serum, stored clinical pathology samples. |
| Data collection, storage, processing systems |
Gentra® automated DNA extraction, all samples aliquoted, master DNA plates created after Picogreen quantification, Sequenom® available for candidate gene analysis |
| Method of consent, reporting of results |
Subjects given broad written informed consent to access to their medical records, data and samples, all of which can be shared with external investigators after de-identification. Investigators are required to deposit data back into the Personalized Medicine Research Project (PMRP) database within 6 months after completing a study. Subjects who did not opt out receive a study newsletter 2-3 times per year. Participants do not receive individual genetic results. |
| Health outcomes of interest |
Current active genetic epidemiology studies include: Alzheimer’s Disease, age-related macular degeneration, cataract, glaucoma, high density lipoprotein (HDL), osteoporosis, fibromyalgia, congestive heart failure, coronary artery disease, myocardial infarction, prostate cancer.
Current active pharmacogenetics studies include: statin response, glaucoma medications, Tamoxifen adverse reactions, sulfa delayed hypersensitivity, ACE and angioedema
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| Funding Sources |
Initial Phase 1 recruitment: Health Resources Services Administration, Wisconsin Department of Commerce, Marshfield Clinic. Study-specific funding: National Human Genome Research Institute, National Cancer Institute, Agency for Health Care Research and Quality, National Heart Lung and Blood Institute, Marshfield Clinic donors |
