|Name of Biobank
||Cancer Prevention Study-3 (CPS-3)
||Pilot work initiated in 2006; full-enrollment launched in 2008
|Primary objective (one sentence)
|Key components (please briefly address the following):
||Initial recruitment is planned through the year 2013.
Cohort follow-up is planned for at least the next 20-30 years.
|Sample size (current and anticipated) and characteristics (age, gender)
||73,467 recruited to date; 500,000 anticipated.
Age 30-39 years (24.9%), 40-49 years (36.4%), 50-59 years (29.9%), 60-65 years (7.8%)
|Recruitment area, method of recruitment/follow-up, sample representativeness
||Recruitment in 29 U.S. states, District of Columbia, and Puerto Rico (these areas encompass 90% of the U.S. population).
Recruitment is taking place through a variety of American Cancer Society (ACS) venues, primarily “Relay For Life” (the signature fund-raising event of the Society), as well as recruitment at local Society offices and corporate partner worksites.
Follow-up has not yet begun, but is planned through (1) active methods of mailed follow-up questionnaires for case ascertainment and updating modifiable exposure information, and (2) passive methods of linkage to state tumor registries.
|Types of data/specimens collected (questionnaire, physical exam)
||Blood specimens (including plasma, buffy coat, red blood cells, and whole blood for cryopreservation of viable lymphocytes), questionnaires, and physical measurements (waist circumference, measured weight, measured height, resting heart rate, and blood pressure) are being collected.
|Data collection, storage, processing systems
||Questionnaire data stored in-house on a secure server; processing and analytic work done via SAS processing system.
Blood specimens stored in LN2 vapor-phase at a central repository (Fisher Bioservices, Inc.); processing and tracking systems through BSI.
|Method of consent, reporting of results
||Written consent obtained and witnessed at the time of initial enrollment and blood collection. Consent form explicitly states individual study results will not be shared. Study findings of interest shared in aggregate through annual study participant newsletters.
|Health outcomes of interest
||Cancer incidence (validated through medical record or tumor registry linkage), mortality from all-causes (and cause-specific), other medical conditions ascertained through self-report (but no plans currently to validate)
||American Cancer Society