Molecular Libraries and Imaging

Funded Research

Molecular Libraries Screening Centers and Small Molecule Repository
Molecular Libraries Probe Production Centers Network (MLPCN) (U54) – Limited Competition
RFA-RM-08-005
PI Name Institution Name Title
AUBE, JEFFREY UNIVERSITY OF KANSAS University of Kansas Specialized Chemistry Center
JACKSON, MICHAEL SANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCH Burnham Center for Chemical Genomics
JONSSON, COLLEEN SOUTHERN RESEARCH INSTITUTE Southern Research Specialized Biocontainment Screening Center (SRSBSC)
LI, MIN JOHNS HOPKINS UNIVERSITY Johns Hopkins Ion Channel Center
LINDSLEY, CRAIG VANDERBILT UNIVERSITY The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development
ROSEN, HUGH THE SCRIPPS RESEARCH INSTITUTE The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps
SCHREIBER, STUART BROAD INSTITUTE Broad Institute Comprehensive Screening Center
SIMEONOV, ANTON NCATS NIH Chemical Genomics Center
SKLAR, LARRY UNIVERSITY OF NEW MEXICO University of New Mexico Center for Molecular Discovery

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Molecular Libraries Screening Centers Network (MLSCN)
RFA-RM-04-017
PI Name Institution Name Title
AUSTIN, CHRIS U.S. NATIONAL HUMAN GENOME RESEARCH INST NIH Chemical Genomics Center (NCGC)
DIAMOND, SCOTT UNIVERSITY OF PENNSYLVANIA The Penn Center for Molecular Discovery
DINGLEDINE, RAYMOND EMORY UNIVERSITY Emory Chemistry-Biology Center in the MLSCN
LAZO, JOHN UNIVERSITY OF PITTSBURGH AT PITTSBURGH University of Pittsburgh Molecular Libraries Screening Center
PIAZZA, GARY SOUTHERN RESEARCH INSTITUTE Southern Research Molecular Libraries Screening Center
REED, JOHN THE BURNHAM INSTITUTE San Diego Center for Chemical Genomics
ROSEN, HUGH THE SCRIPPS RESEARCH INSTITUTE Scripps Research Institute Molecular Screen Center(RMI)
ROTHMAN, JAMES COLUMBIA UNIVERSITY MEDICAL CENTER MLSCN Center at Columbia University
SKLAR, LARRY UNIVERSITY OF NEW MEXICO ALBUQUERQUE New Mexico Molecular Libraries Screening Center
WEAVER, C. DAVID VANDERBILT UNIVERSITY Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters

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CONTRACTS
PI Name Institution Name Title
LIVINGSTON, DOUG BIOFOCUS DPI, A GALAPAGOS COMPANY Molecular Libraries Small Molecule Repository Exit Disclaimer

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)
PAR-09-129
PI Name Institution Name Title
ADHIKARI, SANJAY   GEORGETOWN UNIVERSITY Screening of inhibitors for human 5-prime-tyrosyl DNA phosphodiesterase (hTDP2)
ALDRICH, COURTNEY C UNIVERSITY OF MINNESOTA TWIN CITIES A fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis
ALTSHULER, DAVID   MASSACHUSETTS GENERAL HOSPITAL Identifying the Molecular Pathways Regulating Glucose-dependent Insulin Secretion
ARNER, ELIAS S.J. KAROLINSKA INSTITUTE HTS FOR DRUGS TARGETING THE MAMMALIAN SELENOPROTEIN THIOREDOXIN REDUCTASE 1
ARNOLD, ALEXANDER UNIVERSITY OF WISCONSIN MILWAUKEE Small molecule inhibitors of the vitamin D receptor-coactivator interaction
ATKINS, JOHN F. UNIVERSITY OF UTAH High Throughput Screening for Foot and Mouth Disease Virus Antivirals
BARAK, LAWRENCE S. DUKE UNIVERSITY Small Molecule Agonsists for the Neurotensin 1 Receptor
BARROW, JAMES (contact)
FERRER, MARC
WEINBERGER, DANIEL 		LIEBER INSTITUTE, INC. High Throughput Screening for Specific Inhibitors and Modulators of A Novel Potas
BASSLER, BONNIE L PRINCETON UNIVERSITY A High-Throughput Screen for Modulators of Quorum Sensing in Vibrio cholerae
BERTHELSEN, JENS   UNIVERSITY OF COPENHAGEN Small-molecule inhibitors of hADAM12
BISHAI, WILLIAM RAMSES JOHNS HOPKINS UNIVERSITY Screen for Synthetic lethality in Mycobacterium Tuberculosis
BISWAL, SHYAM   JOHNS HOPKINS UNIVERSITY Development of inlammasome inhibitors to be used as anti-inflammatory agents
BOTTINI, NUNZIO LA JOLLA INST FOR ALLERGY & IMMUNOLGY Small molecule inhibitors of LMPTP: an obesity drug target
BROSH, ROBERT M (contact)
BOHR, VILHELM A 		U.S. NATIONAL INSTITUTE ON AGING High Throughput Screening to Identify Inhibitors of the WRN Syndrome Helicase
CANNON, RICHARD D UNIVERSITY OF OTAGO Identification of Broad-spectrum Antifungal Efflux Pump Inhibitors
CAULFIELD, MICHAEL J INTERNATIONAL AIDS VACCINE INITIATIVE Screening for HIV-1 envelope mimetics from small molecule libraries
CHEN, JAMES K STANFORD UNIVERSITY A high-throughput screen for small-molecule antagonists of Gli function
CHUNG,DONGHOON UNIVERSITY OF LOUISVILLE A Cell-based HTS to discover molecules that inhibit VEEV, encephalitic alphavirus
CLARK, RACHAEL ANN BRIGHAM AND WOMEN'S HOSPITAL Identification of agents that induce E-selectin on human endothelial cells
CONNOR, JOHN H BOSTON UNIVERSITY MEDICAL CAMPUS Stage-Specific Inhibitors of Orthopoxviruses
CONTESSA, JOSEPH N YALE UNIVERSITY A bioluminescent screen for inhibitors of N-linked glycosylation
CRABTREE, GERALD R STANFORD UNIVERSITY Screen for Small Molecule Inhibitors of ATP Dependent Chromatin Remodeling
DALLMANN, H. GARRY UNIVERSITY OF COLORADO AT BOULDER Screening for Inhibitors of DNA Replication in Gram-Positive Bacteria
DANG, LENNY AGIOS PHARMACEUTICALS, INC. HTS for inhibitors of IDH1m & synthetic-lethal in tumor cells producing 2HG
DAUGHERTY, PATRICK S UNIVERSITY OF CALIFORNIA SANTA BARBARA Serine protease zymogen activation by small molecules
DAVEY, ROBERT A UNIVERSITY OF TEXAS MEDICAL BR GALVESTON HTS for Filo- and Arena-virus Entry Mechanisms
DESHAIES, RAYMOND J CALIFORNIA INSTITUTE OF TECHNOLOGY HTS for Rpn11 chemical probes
DISNEY, MATTHEW D SCRIPPS FLORIDA HTS to Identify Small Molecules Targeting Repeating Transcripts
DONG, XINZHONG JOHNS HOPKINS UNIVERSITY A screen for small molecule modulators of human GPCR MrgX1
ERKINE, ALEXANDRE M. BUTLER UNIVERSITY Selective Inhibitors of Human HSF2
FISHER, PAUL B VIRGINIA COMMONWEALTH UNIVERSITY Screening strategy for small molecules inhibitors of cancer
FLAUMENHAFT, ROBERT C BETH ISRAEL DEACONESS MEDICAL CENTER Identification of small molecule inhibitors of protein disulfide isomerase
FLETTERICK, ROBERT J UNIVERSITY OF CALIFORNIA SAN FRANCISCO Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
FORTE, MICHAEL A (contact)
BOURDETTE, DENNIS NEIL		 OREGON HEALTH AND SCIENCE UNIVERSITY Small Molecules Targeting the Mitochondrial Permeability Transition
FREED, ERIC NATIONAL CANCER INSTITUTE Discovery of lead compounds that inhibit HIV-1 budding by blocking the interaction
FRIZZELL, RAYMOND A  UNIVERSITY OF PITTSBURGH AT PITTSBURGH Trans-NIH Research Support
FRYDMAN, JUDITH STANFORD UNIVERSITY High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity
GEHRING, KALLE MCGILL UNIVERSITY HTS Screening for small-molecule inhibitors of microRNA-mediated mRNA deadenylati
GEISS, BRIAN COLORADO STATE UNIVERSITY-FORT COLLINS A High-Throughput Assay for Probes of the Flavivirus RNA Guanylyltransferase
GERSHENGORN, MARVIN C U.S. NATIONAL INST DIABETES/DIGST/KIDNEY High Throughput Screening for Biased Agonists of the TSH Receptor that Activate t
GERSHENGORN, MARVIN C U.S. NATIONAL INST DIABETES/DIGST/KIDNEY Quantitative High-Throughput Screening for Small Molecule Antagonists of Human TSHR
GERSHENGORN, MARVIN C U.S. NATIONAL INST DIABETES/DIGST/KIDNEY qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor
GLIMCHER, LAURIE HOLLIS HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) Schnurri-3 Inhibitors: specific inducers of adult bone formation
GOLUBKOV, VLADISLAV SANFORD-BURNHAM MEDICAL RESEARCH INSTIT A High Content Screen to Identify Inhibitors of MT1-MMP Activation
GOTTESMAN, MICHAEL (contact)
HALL, MATTHEW DAVID
SIMEONOV, ANTON MOMTCHILOV
KOPIN, ALAN S 		NATIONAL CANCER INSTITUTE A high-throughput screen for MDR1-selective chemotherapeutics
GOULD, ROBERT BROAD INSTITUTE, INC. Screen for Inhibitors of STK-33 Kinase Activity
GRAVES, STEVEN W UNIVERSITY OF NEW MEXICO High-throughput multiplex microsphere screening for toxin protease inhibitors
GRIMALDI, MAURIZIO SOUTHERN RESEARCH INSTITUTE A fully validated assay to identify activators of ERSR in human glioma cells: identification of small molecules with potential gliotoxic activity
HAHN, WILLIAM C  DANA-FARBER CANCER INSTITUTE Discovering modulators of PAX8 for targeting ovarian cancer
HALDAR, KASTURI (contact)
ZHENG, WEI		 UNIVERSITY OF NOTRE DAME Malaria Phosphatase Inhibitors Identified as a Potential New Malaria Treatment
HARDY, JEANNE ANN  UNIVERSITY OF MASSACHUSETTS AMHERST Caspase-6 allosteric inhibitors: activity probes and neurodegeneration treatment
HARLAN-WILLIAMS, LISA M UNIVERSITY OF KANSAS MEDICAL CENTER  HTS Assay to Identify Small Molecule Activators of BRCA1 Expression
HARRIS, REUBEN S UNIVERSITY OF MINNESOTA TWIN CITIES APOBEC3G DNA Deaminase Inhibitor High Throughput Screen
HERZBERG, OSNAT UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS Compound library screening using Giardia labmblia high throughput viability assay
HU, LONGQIN RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction
IADAROLA, MICHAEL J U.S. NAT'L INST/DENTAL/CRANIOFACIAL RES HTS for Identifying Allosteric Modulators of TRPV1 receptor
IMPERIALI, BARBARA MASSACHUSETTS INSTITUTE OF TECHNOLOGY Inhibition of Glycoprotein Biosynthesis in Gram-Negative Pathogens
INIGUEZ LLUHI, JORGE A UNIVERSITY OF MICHIGAN AT ANN ARBOR Chemical probes targeting the SUMO protease SENP1 in Prostate Cancer
IOANNOU, YIANNIS A MOUNT SINAI SCHOOL OF MEDICINE OF NYU HTS of NPC1 promoter activators
IOANNOU, YIANNIS A MOUNT SINAI SCHOOL OF MEDICINE OF NYU HTS of Rab9 Promoter Activators
JACOBSON, DAVID AARON VANDERBILT UNIVERSITY Small molecule modulators of the two-pore-domain potassium channel, TREK-2
JANZEN, WILLIAM PERRY UNIVERSITY OF NORTH CAROLINA CHAPEL HILL High-Throughput Screening for the Discovery of Novel Scaffolds that Antagonize Methylated Histone Recognition
JARVIK, JONATHAN W CARNEGIE-MELLON UNIVERSITY HTS FOR NON-CANONICAL LIGANDS FOR BETA 2 ADRENERGIC RECEPTOR INTERNALIZATION
JENKINSON, SARAH RHIANNON (contact);
CHEN, CATHERINE;
HODES, RICHARD JOEL		 NATIONAL CANCER INSTITUTE Identification of small molecule activator of co-stimulatory pathways for T cell
JENNINGS, PATRICIA A UNIVERSITY OF CALIFORNIA SAN DIEGO HTS for Modulators of MitoNEET Proteins' Function
JONSSON, COLLEEN B UNIVERSITY OF LOUISVILLE Discovery of Small Molecule Probes for Influenza NS1A
KAUFMAN, RANDAL J UNIVERSITY OF MICHIGAN AT ANN ARBOR HTP chemical genomic screens to identify positive regulators of the Unfolded Protein Response
KIM, HEE-YONG U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM High Throughput Screening (HTS) for Akt/mTORC2: Identification of Novel Inhibitor
KITSIS, RICHARD N ALBERT EINSTEIN COL OF MED YESHIVA UNIV High-Throughput Screen for Small Molecules that Modulate Myocardial Damage
KOH, MEI YEE UNIVERSITY OF TEXAS MD ANDERSON CAN CTR High-throughput screen for specific small-molecule inhibitors of HIF-2A activity
KOPIN, ALAN S TUFTS MEDICAL CENTER Bursicon Receptor Antagonists: Templates for Developing Novel Insecticides
KRISHNAMURTHY, PARTHA C UNIVERSITY OF KANSAS MEDICAL CENTER High Throughput Screening for Inhibitors of the ABC Transporter ABCB6
KUNG, ANDREW L (contact)
STEGMAIER, KIMBERLY 		DANA-FARBER CANCER INSTITUTE Targeting the ETS Transcription Factor Rearrangement EWS/FLI in Ewing's Sarcoma
LANDER, ERIC S BROAD INSTITUTE, INC. High-throughput screening for small molecules with specific toxicity for breast cancer stem cells
LASMEZAS, CORINNE IDA  SCRIPPS FLORIDA High Throughput Screening for compounds reducing cell surface prion protein
LEE, JEANNIE T MASSACHUSETTS GENERAL HOSPITAL HTS of Gamma Glutamyl Transpeptidase for the Discovery of Novel Antimicrobials
LIANG, T. JAKE (contact)
ZHENG, WEI 		U.S. NATIONAL INST DIABETES/DIGST/KIDNEY Quantitative High Throughput Screen to Identify Novel Antivirals against Hepatiti
LIEBER, MICHAEL R UNIVERSITY OF SOUTHERN CALIFORNIA Selective Inhibitors of the Artemis Endonuclease
LINDQUIST, SUSAN L. WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Identification of malaria Hsp40 chaperone inhibitors in yeast
LINDQUIST, SUSAN L. WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Identification of compounds that reverse cellular toxicity of A beta peptide in a
LLOYD, R STEPHEN OREGON HEALTH AND SCIENCE UNIVERSITY Inhibitors of DNA polymerase kappa
LORSCH, JON R JOHNS HOPKINS UNIVERSITY Modulators of the fidelity of start codon recognition in eukaryotes
LU, KUN PING BETH ISRAEL DEACONESS MEDICAL CENTER Identification of Pin1 Chemical Probes for Studying Phosphorylation Signaling
MAEGAWA, GUSTAVO HENRIQUE BOFF  JOHNS HOPKINS UNIVERSITY A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase
MAHLEY, ROBERT W. J. DAVID GLADSTONE INSTITUTES ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
MANKIN, ALEXANDER S (contact)
ORELLE, CEDRIC 		UNIVERSITY OF ILLINOIS AT CHICAGO Inhibitors of Bacterial Protein Synthesis with Novel Modes of Action
MARCHAND, CHRISTOPHE NATIONAL CANCER INSTITUTE Quantitative High-throughput Discovery of Human Tyrosyl-DNA Phosphodiesterase I (Tdp1) Inhibitors
MARUGAN, JUAN J (contact)
FERRER, MARC 
OLEFSKY, JERROLD MICHAEL 		U.S. NATIONAL HUMAN GENOME RESEARCH INST Identification of GPR120 B-arrestin-2 Biased Agonists for the Treatment of Insuli
MAURIZI, MICHAEL ROBERT NATIONAL CANCER INSTITUTE High throughput screen to identify activators of Bacillus subtilis ClpP with anti
MAZIN, ALEXANDER V DREXEL UNIVERSITY Development of RAD52 inhibitors to induce synthetic lethality of BRCA2-deficient
MAZIN, ALEXANDER V DREXEL UNIVERSITY Identification of inhibitors of RAD54, an important DNA repair protein
MINOND, DMITRIY TORREY PINES INST FOR MOLECULAR STUDIES HTS Assays to Discover Selective Inhibitors of ADAM10 and 17
MOWEN, KERRI A SCRIPPS RESEARCH INSTITUTE An Activity-Based Assay to Screen for PRMT1 Inhibitors
NELSON, WILLIAM GEORGE  JOHNS HOPKINS UNIVERSITY Screen for Small Molecule Antagonists of MBD2
NEUBIG, RICHARD R UNIVERSITY OF MICHIGAN AT ANN ARBOR Cell-based Screen for RGS Modulators
OSTERMAN, ANDREI L SANFORD-BURNHAM MEDICAL RESEARCH INSTIT Inhibitors of Staphylococcus aureus NaMN adenylyltransferase NadD
PARRA, KARLETT J UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Flow Cytometry HTS of Small Molecules that Regulate V-ATPase Proton Transport
PATHAK, VINAY K. NATIONAL CANCER INSTITUTE Identification of Small Molecule Inhibitors of Vif-A3G and Vif-A3F Interactions as Novel Antiviral Agents for Treatment of HIV-1 Infection
PEGAN, SCOTT DUSAN  UNIVERSITY OF DENVER (COLORADO SEMINARY) Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
PETROSKI, MATTHEW SANFORD-BURNHAM MEDICAL RESEARCH INSTIT High throughput screening for modulators of UBC12
POMMIER, YVES NATIONAL CANCER INSTITUTE Identification of human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) repair inhibitors
PRELICH, GREGORY YESHIVA UNIVERSITY A High-throughput in Vivo Screen for Small Molecule Inhibitors of SUMOylation
PROSSNITZ, ERIC R UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR MLP Assay for Arrestin-AP2 Inhibitors
PUIGSERVER, PERE DANA-FARBER CANCER INSTITUTE HTS of Compounds Modulating PGC-1a Acetylation and Oxidative Metabolic Function
REDDY, SITA (contact)
NEAMATI, NOURI 		UNIVERSITY OF SOUTHERN CALIFORNIA High Throughput Screen for Myotonic Dystrophy Type 1
RICKERT, ROBERT C SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE Functional Antagonists of EBI12/GPR183 as chemical probes for inflammation
ROTH, GREGORY PAUL SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis
RUOSLAHTI, ERKKI SANFORD-BURNHAM MEDICAL RESEARCH INSTIT High-throughput screen to identify modulators of CendR-mediated cellular uptake
SABATINI, DAVID M. WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Inhibitors of serine biosynthesis
SALVESEN, GUY S SANFORD-BURNHAM MEDICAL RESEARCH INSTIT Selective Allosteric Inhibitors of SENP8
SASAKI, ATSUO BETH ISRAEL DEACONESS MEDICAL CENTER Chemical probes that modulate a stress pathway phosphatidylinositol 5-phosphate 4
SHAMJI, ALYKHAN   BROAD INSTITUTE, INC. Development of Small-Molecule Probes of the Histone Methyltransferase NSD2
SHEWMAKER, FRANK P  HENRY M. JACKSON FDN FOR THE ADV MIL/MED Molecular library screen for suppressors of FUS proteinopathy
SIBLEY, DAVID R. U.S. NATIONAL INST/NEURO/DS/STROKE Discovery of Novel Allosteric Modulators of the D3 Dopamine Receptor
SIDEROVSKI, DAVID P UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Enzymatic Screen for RGS Protein Modulators
SLUSHER, BARBARA STAUCH JOHNS HOPKINS UNIVERSITY HTS Screening for Glutaminase Inhibitors
SODROSKI, JOSEPH G DANA-FARBER CANCER INSTITUTE Broad-range Inhibitors of Human Immunodeficiency Virus Entry
STAMM, STEFAN UNIVERSITY OF KENTUCKY Identification of substances that change alternative pre-mRNA splicing of the serotonin 2C receptor
STANLEY, JOHN R UNIVERSITY OF PENNSYLVANIA High throughput screening to find inhibitors of pathogenic pemphigus antibodies
STERN, LAWRENCE J UNIV OF MASSACHUSETTS MED SCH WORCESTER Small molecule probes of ERAP-1
SYKES, DAVID B MASSACHUSETTS GENERAL HOSPITAL Discovering small molecules that overcome differentiation arrest in acute myeloid
TAUTZ, LUTZ SANFORD-BURNHAM MEDICAL RESEARCH INSTIT STEP inhibitors for intervention in Alzheimer's Disease
TESMER, JOHN J G UNIVERSITY OF MICHIGAN AT ANN ARBOR RNA Aptamer-Based Screen for Selective Inhibitors of GRK2
TORTORELLA, DOMENICO MOUNT SINAI SCHOOL OF MEDICINE OF NYU Identification of Inhibitors that Stabilize ER Degradation Substrates
TORTORELLA, DOMENICO   MOUNT SINAI SCHOOL OF MEDICINE Identification of novel inhibitors targeting entry of human cytomegalovirus
UMEMORI, HISASHI UNIVERSITY OF MICHIGAN AT ANN ARBOR Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy
VUORI, KRISTIINA SANFORD-BURNHAM MEDICAL RESEARCH INSTIT HTS for Caspase-8 selective TRAIL Sensitizers
WAHL, GEOFFREY MYLES SALK INSTITUTE FOR BIOLOGICAL STUDIES High Throughput Screen for Inhibitors of the mdm2/mdmx Interaction
WALKINSHAW, MALCOLM DOUGLAS UNIVERSITY OF EDINBURGH Identification of glycolytic pathway inhibitors against Trypanosoma cruzi pyruvat
WEISSBACH, HERBERT FLORIDA ATLANTIC UNIVERSITY High Throughput Assay for Activators and Inhibitors of MSRA
WENNERBERG, KRISTER SOUTHERN RESEARCH INSTITUTE Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein M
WHITESELL, LUKE J WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Identifying species-specific anti-malarial Hsp90 inhibitors using genetically engineered yeast
WILSON, SAMUEL H U.S. NATIONAL INST OF ENVIRON HLTH SCIS Discovery and Characterization of Human DNA Polymerase Beta Inhibitors
WOODGATE, ROGER U.S. NATIONAL INST/CHILD HLTH/HUMAN DEV High Throughput Screening to Identify Inhibitors of Human DNA Polymerase eta and polymerase iota
WU, MENG JOHNS HOPKINS UNIVERSITY Subtype-Specific Small Molecule Chemical Probes for Non-neuronal KCNQ1 Potassium Channel
WU, MENG JOHNS HOPKINS UNIVERSITY Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
WU, XIAOHUA CAROLINAS MEDICAL CENTER HTS for Enhancer of Glycosylation of Alpha Dystroglycan
XU, HAOXING UNIVERSITY OF MICHIGAN AT ANN ARBOR Kinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion c
YOULE, RICHARD JAMES U.S. NATIONAL INST/NEURO/DS/STROKE High content screening for small molecule modulators of Pink1 expression and mito
YOUNG, RICHARD A WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Discovery of small molecule inhibitors of c-Myc/Mac dimerization and DNA binding
YUE, DAVID T  JOHNS HOPKINS UNIVERSITY Modulators of CaV1.3 Ca2+ regulation
XU, WEI UNIVERSITY OF WISCONSIN MADISON Identification of ERalpha/ERbeta Heterodimer-specific Ligands by HTS
ZHANG, YAN JESSIE UNIVERSITY OF TEXAS AUSTIN Discovery of Inhibitors for Small C-terminal Domain Phosphatases
ZHAO, RUI (contact)
FORD, HEIDE L 		UNIVERSITY OF COLORADO DENVER Identify inhibitors of the Six1/Eya interaction using high throughput screening
ZHAO, RUI (contact)
ZHANG, QINGHONG		 UNIVERSITY OF COLORADO DENVER Identify Inhibitors of the Transcriptional Co-Repressor CtBP Using HTS for Cancer
ZHENG, WEI, Contact
REMALEY, ALAN THOMAS		 U.S. NATIONAL HUMAN GENOME RESEARCH INST Identification of Acid Sphingomyelinase Inhibitors for the Treatment of Atherosclerosis
ZHENG, WEI (contact)
SHILOH, YOSEF		 U.S. NATIONAL HUMAN GENOME RESEARCH INST HTS for Identifying Potential Drug Treatment of Ataxia-Telangiectasia
ZHUANG, ZHIHAO UNIVERSITY OF DELAWARE Discovery of inhibitors against ubiquitin specific protease in human DNA damage r

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Solicitation of Assays for HTS in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03/X01)
PAR-08-034 & PAR-08-035
PI Name Institution Name Title
ABOOD, MARY E CALIFORNIA PACIFIC MED CTR RES INSTITUTE Screening for Selective Ligands for GPR55
AGOULNIK, ALEXANDER I. BAYLOR COLLEGE OF MEDICINE Small molecule agonists of the relaxin receptor
ANDROPHY, ELLIOT J UNIV OF MASSACHUSETTS MED SCH WORCESTER High Throughput Screen for SMA
BARAK, LAWRENCE S DUKE UNIVERSITY Agonists and Antagonists for the Kappa Opioid Receptor
BASSLER, BONNIE L PRINCETON UNIVERSITY A High-Throughput Screen for LuxS Quorum-Sensing Inhibitors
BRODSKY, JEFFREY L UNIVERSITY OF PITTSBURGH AT PITTSBURGH Identification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent
BUGGE, THOMAS H U.S. NAT'L INST/DENTAL/CRANIOFACIAL RES Inhibitors of Cell Surface uPA Generation
BURHANS, WILLIAM C ROSWELL PARK CANCER INSTITUTE CORP A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide
BUSHWELLER, JOHN HACKETT UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screening for Inhibitors of MLL Translocation Proteins in Leukemia
CHEN, YUAN CITY OF HOPE/BECKMAN RESEARCH INSTITUTE A high throughput screening assay for the identification of SUMOylation inhibitor
DENISON, MICHAEL STEVEN UNIVERSITY OF CALIFORNIA DAVIS High Throughput Screening for Activators of the Ah Receptor
ECKENHOFF, RODERIC G. UNIVERSITY OF PENNSYLVANIA High throughput screening of a general anesthetic binding site
FLAUMENHAFT, ROBERT C BETH ISRAEL DEACONESS MEDICAL CENTER Chemical Genetic Analysis of Platelet Granule Secretion
GARDINER, DONALD L QUEENSLAND INSTITUTE OF MEDICAL RESEARCH Identification of Inhibitors of the Plasmodium Falciparum M18 Metalloprotease
GILEADI, OPHER (contact);
VINDIGNI, ALESSANDRO  		UNIVERSITY OF OXFORD Small-molecule inhibitors of the human RECQ1 and Bloom DNA helicases
GOLUB, TODD R. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Discovery of inhibitors of anti-apoptotic protein A1
GOULD, ROBERT MASSACHUSETTS INSTITUTE OF TECHNOLOGY Discovering Inhibitors of histone demethylase GASC-1
HAGGARTY, STEPHEN J
PAN, JEN (contact) 		MASSACHUSETTS INSTITUTE OF TECHNOLOGY Discovery of potent, and selective allosteric inhibitors of GSK-3b
HARDING, HEATHER P NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screen for Inhibitors of 2' Phosphotransferase
HASLAM, DAVID B WASHINGTON UNIVERSITY A SCREEN FOR SMALL MOLECULE INHIBITORS OF SHIGA TOXIN AND RICIN ACTIVITY
HEIL, MARINTHA L SOUTHERN RESEARCH INSTITUTE A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activ
HEILIG, MARKUS ALEXANDER U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM Identification of Small Molecule Antagonists for the Neuropeptide Receptor Using
HONKANEN, RICHARD E UNIVERSITY OF SOUTH ALABAMA HTP screening for inhibitors of ser/the protein phosphatase 5
HUNG, DEBORAH T MASSACHUSETTS INSTITUTE OF TECHNOLOGY Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis
JARSTFER, MICHAEL B UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Allosteric Potentiators of the Oxytocin System for the Control of Social Motivation
KAUFMAN, RANDAL J UNIVERSITY OF MICHIGAN AT ANN ARBOR High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
KOEHLER, CARLA M. UNIVERSITY OF CALIFORNIA LOS ANGELES Small molecule modulators for mitochondrial protein import
KUPERSHMIDT, SABINA VANDERBILT UNIVERSITY Identification of compounds that protect HERG from block by proarrhythmic agents
LEVINE, ROSS L SLOAN-KETTERING INSTITUTE FOR CANCER RES High Throughput Screen for JAK2V617F Mutant Selective Inhibitors
LI, MIN JOHNS HOPKINS UNIVERSITY Development of Chemical Probes for KCNQ Potassium Channels
LINDQUIST, SUSAN L. WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Reversing Antifungal Drug Resistance
LITTMAN, DAN R NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of
MAKHINA, ELENA UNIVERSITY OF PITTSBURGH AT PITTSBURGH High Throughput Screening for Potassium Channel Modulators
MAZIN, ALEXANDER V DREXEL UNIVERSITY A Screen for Modulators of Human Rad51, a Key DNA Repair Protein
MCDONOUGH, PATRICK M VALA SCIENCES, INC A High Throughput Imaging Assay for Hepatic Lipid Droplet Formation
MILLAN, JOSE LUIS BURNHAM INSTITUTE FOR MEDICAL RESEARCH The Role of PHOSPHO1 in the Initiation of Skeletal Calcification
MISTELI, TOM U.S. NATIONAL CANCER INSTITUTE A high-throughput screen for pre-mRNA splicing modulators
MOORE, CLAIRE L;
KUMAMOTO, CAROL A		 TUFTS UNIVERSITY BOSTON High throughput screening for polyadenylation inhibitors using the MLSCN library
NAKAMURA, KAZUHIRO UNIVERSITY OF NORTH CAROLINA CHAPEL HILL TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain Interaction
PAULUS, HENRY BOSTON BIOMEDICAL RESEARCH INSTITUTE Intein inhibitors as potential TB drugs
PELLECCHIA, MAURIZIO BURNHAM INSTITUTE FOR MEDICAL RESEARCH Novel Chemical Probes Targeting the FRB Domain of mTOR
PELLETIER, JERRY MC GILL UNIVERSITY Interdicting Eukaryotic Translation Initiation Factor-RNA Interaction
REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH High Throughput Screening Assays for NOD1 and NOD2 Inhibitors
REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH Chemical Modulation of the Siah-1 Pathway
REISMAN, DAVID N UNIVERSITY OF MICHIGAN AT ANN ARBOR Reverse the Epigenetic Suppression of BRM through High Throughput Screening
RUGGIERO, ALICIA M. VANDERBILT UNIVERSITY A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators
STOCKWELL, BRENT R COLUMBIA UNIV NEW YORK MORNINGSIDE Screen for RAS-Selective Lethal Compounds and VDAC Ligands
SUN, HONGMIN UNIVERSITY OF MISSOURI-COLUMBIA High Throughput Screening for Small Compounds to Inhibit the Expression of Strept
THORNTON, CHARLES A. UNIVERSITY OF ROCHESTER Inhibitors of MBNL1 - poly(CUG)binding
WANG, ZHIYONG SALK INSTITUTE FOR BIOLOGICAL STUDIES High throughput screen for the master regulator of obesity and diabetes p/CIP
WERNER-WASHBURNE, MARGARET C. UNIVERSITY OF NEW MEXICO Chemical Screen of TOR pathway GFP fusion proteins in S. cerevisiae
WHITESELL, LUKE J WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Identifying Small Molecules To Probe the Role of Heat Shock Factor 1 in Cancer
WILSON, DAVID M. U.S. NATIONAL INSTITUTE ON AGING High Throughput Screening to Identify Inhibitors of the Human Abasic Endonuclease
YANG, VINCENT W EMORY UNIVERSITY High Throughput Screen for Small Molecule Inhibitors of Colorectal Cancer Cell Pr
ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INST Identification of Activators and Inhibitors of alpha-Glucosidase as Potential Cha
ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INST HTS for Identifying Activators and Inhibitors of Alpha-Galactosidase A for the Po

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03/X01)
PAR-06-259 & PAR-06-545
PI Name Institution Name Title
BALLATORE, CARLO UNIVERSITY OF PENNSYLVANIA High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi
BUGGE, THOMAS H U.S. NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH Quantitative High Throughput Screening for Anthrax Toxin Inhibitors
BURKART, MICHAEL D UNIVERSITY OF CALIFORNIA SAN DIEGO A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases
BUSHWELLER, JOHN H UNIVERSITY OF VIRGINIA CHARLOTTESVILLE High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3
BUSHWELLER, JOHN H UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screening for Inhibitors of Runx and CBFb Translocation Products in Leukemia
COOMBS, GARY UNIVERSITY OF UTAH The Role of Wnts in Stem Cell
DAY, BILLY W UNIVERSITY OF PITTSBURGH AT PITTSBURGH HTS Assays for Microtubule Stabilizers
FREEZE, HUDSON H BURNHAM INSTITUTE FOR MEDICAL RESEARCH Therapeutic Inhibitors of Phosphomannose Isomerase
GARDINER, DONALD L (Contact);
TRENHOLME, KATHARINE RUTH
DALTON, JOHN PIU		 QUEENSLAND INSTITUTE OF MEDICAL RESEARCH High Through-Put Screening of Plasmodium Falciparum Aminopeptidases
GERSHENGORN, MARVIN C U.S. NATIONAL INST DIABETES/DIGST/KIDNEY Ligand Discovery for Thyroid-Stimulating Hormone Receptor (TSHR) by Virtual and H
GLASS, JONATHAN DAVID EMORY UNIVERSITY Discovering Calpain Inhibitors of Neurological Diseases
GRIMALDI, MAURIZIO SOUTHERN RESEARCH INSTITUTE An HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators
HASELBECK, ROBERT JOHN RX3 PHARMACEUTICALS, INC. Identification of Target-Specific Antimicrobials
HELLER, STEFAN STANFORD UNIVERSITY Identification of Modulators of the TRPML3 and TRPN1 ion Channels
HOLMAN, THEODORE R UNIVERSITY OF CALIFORNIA SANTA CRUZ High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors
KOLE, RYSZARD UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Modulation of Alternative Splicing by HTS Identified Compounds
LARSON, RICHARD S UNIVERSITY OF NEW MEXICO ALBUQUERQUE Multiplex Screening for ABC Transporter Inhibitors
LEISSRING, MALCOLM A SCRIPPS RESEARCH INSTITUTE HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme
LEWIS, KIM NORTHEASTERN UNIVERSITY Screening C. Albicans Biofilms for Lethal Potentiators of Miconazole
LI, QIANJUN UNIVERSITY OF ALABAMA AT BIRMINGHAM A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
LIU, PU PAUL U.S. NATIONAL HUMAN GENOME RESEARCH INST High-Throughput Screening for Compounds Blocking Interaction Between CBFb-SMMHC a
MARSHALL, WALLACE UNIVERSITY OF CALIFORNIA SAN FRANCISCO Small Molecule Inhibitors of Cilia
MATTS, ROBERT L OKLAHOMA STATE UNIVERSITY STILLWATER High Throughput Screen for Hsp90 Inhibitors
MCDONOUGH, PATRICK M VALA SCIENCES, INC High Throughput Imaging Assay for Beta-Catenin
MCNEIL, MICHAEL R COLORADO STATE UNIVERSITY – FORT COLLINS HTS Screen of TB RmIC & RmID dTDP-Rhamnose Formation Enzymes
MILLAN, JOSE LUIS BURNHAM INSTITUTE FOR MEDICAL RESEARCH Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
MORRIS, JAMES CULVIN CLEMSON UNIVERSITY Identification of Inhibitors of Trypanosoma Brucei Hexokinases
NATARAJAN, AMARNATH UNIVERSITY OF TEXAS MEDICAL BR GALVESTON HTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Int
NUNNARI, JODI M UNIVERSITY OF CALIFORNIA DAVIS Chemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors
PASSER, BRENT J MASSACHUSETTS GENERAL HOSPITAL A High-Throughput Screen to Identify Small Molecule Compounds That Augment
PELLECCHIA, MAURIZIO BURNHAM INSTITUTE FOR MEDICAL RESEARCH Novel Chemotypes Against Influenza A Virus
PELLETIER, JERRY MCGILL UNIVERSITY Screening for Small Molecule Inhibitors of Eukaryotic Translation Initiation
PLEMPER, RICHARD K. EMORY UNIVERSITY High Throughput Screening-Based Identification of Measles Virus Probes
REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins
REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH Chemical Inhibitors of ER Stress
RON, DAVID NEW YORK UNIVERSITY SCHOOL OF MEDICINE Screening for Inhibitors of the Integrated Stress Response
ROZANOV, DMITRI BURNHAM INSTITUTE FOR MEDICAL RESEARCH Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells
SEVERSON, WILLIAM E SOUTHERN RESEARCH INSTITUTE A Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus
SEVERSON, WILLIAM E SOUTHERN RESEARCH INSTITUTE A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV
SHOICHET, BRIAN K UNIVERSITY OF CALIFORNIA SAN FRANCISCO Promiscuous and Specific Inhibitors of Cruzain
SMITH, SUSAN M.E. EMORY UNIVERSITY HTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes
SMITHGALL, THOMAS EDWARD UNIVERSITY OF PITTSBURGH AT PITTSBURGH Targeting HIV-1 Nef with Small Molecules
STAUFFACHER, CYNTHIA V PURDUE UNIVERSITY WEST LAFAYETTE Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
STOCKWELL, BRENT R COLUMBIA UNIV NEW YORK MORNINGSIDE Luciferase Screen for MDM2 E3 Ligase Inhibitors
TOBIAS, PETER S SCRIPPS RESEARCH INSTITUTE High Throughput Screening for Toll-Like Receptors
WANDINGER-NESS, ANGELA UNIVERSITY OF NEW MEXICO ALBUQUERQUE HTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras-
WANG, QIMING JANE UNIVERSITY OF PITTSBURGH AT PITTSBURGH IMAP-Based Fluorescent Polarization Assay for High Throughput Screening of Protein
YIN, XIAO-MING UNIVERSITY OF PITTSBURGH AT PITTSBURGH High-Content Cell-Based Screening for Modulators of Autophagy
YUAN, JUNYING HARVARD UNIVERSITY (MEDICAL SCHOOL) A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway
ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE HTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors
ZHENG, WEI U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE HTS for Identification of Inhibitors Against the ERK Signaling Pathway using a Ho

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147
PAR-06-259
PI Name Institution Name Title
DE FIGUEIREDO, PAUL TEXAS A&M UNIVERSITY SYSTEM Drug Discovery for Bone Marrow Failure Diseases
FRANK, DAVID A DANA-FARBER CANCER INSTITUTE Modulators of STAT transcription factors for the targeted therapy of cancer
GRIFFIN, PATRICK R SCRIPPS RESEARCH INSTITUTE HTRF screen for identifying SRC-1 selective agonists of PPARgamma
GU, HOWARD H OHIO STATE UNIVERSITY High Throughput Screening for Cocaine Antagonists
KUHN, PETER SCRIPPS RESEARCH INSTITUTE EphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition
LIOU, HSIOU-CHI IMMUNETARGET, INC. Development of Screening Assays for NF-KB-Rel Inhibitors
MARTINEZ, ELISABETH D UNIVERSITY OF TEXAS SW MED CTR/DALLAS High Throughput Screens for Epigenetic Modulators
MERCOLA, MARK BURNHAM INSTITUTE FOR MEDICAL RESEARCH Screen for Compounds that Promote Cardiomyocyte Cell Cycle Entry
NICHOLSON, BENJAMIN PROGENRA, INC. Identification of Compounds that Modulate Human Deubiquitinase Function
NIRENBERG, MARSHALL WARREN U.S. NATIONAL HEART LUNG & BLOOD INS Molecules that Enhance CREB Activity
QU, ZHICAN SOUTHERN RESEARCH INSTITUTE Cell-Based Screening for Anti-Angiogenic Agents
REED, JOHN C BURNHAM INSTITUTE FOR MEDICAL RESEARCH High Throughput Screening Assay for Hsp70 Inhibitors
ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL MLSCN SCReen of the Amyloid precursor protein 5'untranslated region
SEIDAH, NABIL G. CLINICAL RESEARCH INSTITUTE OF MONTREAL High Throughput Screens for targets of the Proprotein Convertases Furin, PC5, SKI-1 and PCSK9 Using Cell-Based Assays
SHOICHET, BRIAN K. UNIVERSITY OF CALIFORNIA SAN FRANCISCO Promiscuous and Specific Inhibitors of B-lactamase
SKLAR, LARRY A. UNIVERSITY OF NEW MEXICO ALBUQUERQUE HTS for BCI-2 Family Multiplex
SUN, YI UNIVERSITY OF MICHIGAN-ANN ARBOR Synthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147
PAR-06-259
PI Name Institution Name Title
AULD, DOUGLAS S NIH/NHGRI Identification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A
BRISSON, MARNI J UNIVERSITY OF PITTSBURGH Homogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase I
DESAI, SANJAY A NAT'L INST OF ALLERGY/INFEC DISE High-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC)
FIELDS, GREGG B FLORIDA ATLANTIC UNIVERSITY ADAMTS/MMP Drug Development
GRESHAM, HATTIE D UNIVERSITY OF NEW MEXICO ALBUQUERQUE Small Molecule Inhibition of Staphylococcus Aureus Virulence
HAMMOCK, BRUCE D UNIVERSITY OF CALIFORNIA DAVIS Novel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammat
HOFFMANN, MICHAEL UNIVERSITY OF WISCONSIN Targeting a Protein Interaction Site on Smad Transcription Factors
KATZENELLENBOGEN, JOHN A UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Screen for Coactivator Binding Inhibitors to Block Estrogen Action
KELLY, JEFFERY W SCRIPPS RESEARCH INSTITUTE High Throughput Screening for Protein Misfolding Disease Therapeutics
LEYH, THOMAS S. YESHIVA UNIVERSITY Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae
MCPIKE, MARK P ORTHOSYSTEMS, INC. Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery
PELLECCHIA, MAURIZIO BURNHAM INSTITUTE Chemical Tools to Investigate the Protein Folding/Degradation Machinery
STRONGIN, ALEX BURNHAM INSTITUTE Screening Chemicals to Suppress MT1-MMP Synthesis in Cancer
THOMPSON, TODD A UNIVERSITY OF NEW MEXICO ALBUQUERQUE Activators of Prostate Cell Differentiation
WELLS, JAMES A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Inhibitors of Caspase-1 and Caspase-7
WILLIAMSON, JAMES R SCRIPPS RESEARCH INSTITUTE High Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction
YAFFE, MICHAEL MASSACHUSETTS INST OF TECHNOLO High Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Lik
ZHENG, WEI NIH/ NHGRI HTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmac

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (X01) Reissue of PAR-05-060
PAR-05-147
PI Name Institution Name Title
CONN, P JEFFREY VANDERBILT UNIVERSITY Discovery of novel allosteric modulators of the M1 muscarinic receptor
HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Chemical Genetics Screens to Identify Modulators of Post-Golgi Transport
KURET, JEFF A OHIO STATE UNIVERSITY Ligands for premortem diagnosis and treatment of Alzheimer's disease
LEWIS, KIM A NORTHEASTERN UNIVERSITY A Screen for Novel Antimicrobials
LI, XIAOLING ORPHAGEN PHARMACEUTICALS High Throughput Screening of Select Orphan Nuclear Receptors
MCHENRY, CHARLES S UNIVERSITY OF COLORADO DENVER/HSC AURORA Conducting a HTS against a Multi-protein DNA Replication System
MERCOLA, MARK BURNHAM INSTITUTE Screening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells
MERCOLA, MARK BURNHAM INSTITUTE Screening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells
MILLAN, JOSE LUIS BURNHAM INSTITUTE Pharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
MUSTELIN, TOMAS M BURNHAM INSTITUTE HTS for HePTP Inhibitors-a leukemia target
MUSTELIN, TOMAS M BURNHAM INSTITUTE HTS for LYP inhibitors-an autoimmunity target
NISWENDER, COLLEEN M VANDERBILT UNIVERSITY Discovery of novel allosteric agonists of the M4 muscarinic receptor
PARNIAK, MICHAEL A UNIVERSITY OF PITTSBURGH AT PITTSBURGH HTS assays for inhibitors of HIV RNase H
PASQUALE, ELENA B BURNHAM INSTITUTE EphA4 Receptor Antagonists for Nervous System Repair
PAVITT, GRAHAM D UNIVERSITY OF MANCHESTER, UK High-throughput screen for a therapeutic agent for elF2B-related disorders
PIAZZA, GARY A SOUTHERN RESEARCH INSTITUTE Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance
PROSSNITZ, ERIC R UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors
PROSSNITZ, ERIC R UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Inhibitors of Arrestin-GPR Interactions
REED, JOHN C BURNHAM INSTITUTE Chemical Inhibitors of anti-apoptotic protein Bfl-1
REED, JOHN C BURNHAM INSTITUTE Chemical inhibitors of antigen receptor-induced NF-?Beta activation
RUBENSTEIN, AMY L ZYGOGEN, LLC Zebrafish Lipid Metabolism Assay
SHARLOW, ELIZABETH R. UNIVERSITY OF PITTSBURGH Fluroscence polarization assay for PLK1 inhibitors
SKLAR, LARRY A UNIVERSITY OF NEW MEXICO ALBUQUERQUE MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin
SKOWYRA, DOROTA ST. LOUIS UNIVERSITY ATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for fl
STRONGIN, ALEX Y BURNHAM INSTITUTE Inhibitors of the NS3 Proteinase of West Nile and Dengue Viruses
STURGESS, MICHAEL A CHAPERONE TECHNOLOGIES, INC. Development of a HTS assay for Inhibitors of bacterial DnaK
WATTS, VAL J PURDUE UNIVERSITY WEST LAFAYETTE Allosteric Modulators of D1 Receptors
YI, FANG YALE UNIVERSITY Identifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction usin

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Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (R03)
PAR-05-060
PI Name Institution Name Title
APPEL, BRUCE VANDERBILT UNIVERSITY A Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish
CHEN, BENJAMIN P UNIVERSITY OF TEXAS SW MED CTR/DALLAS TRANSLATIONAL CONTROL OF RADIATION-INDUCED APOPTOSIS
CHENG, XIAODONG UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Chemical Genetic Screening of Oncogene RAS-Based Inhibitors
CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES FP Assay for Isolation of Hsp90 Inhibitors
CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES Isolation of Inhibitors of Her-Kinase Expression
DIAMOND, SCOTT L UNIVERSITY OF PENNSYLVANIA Multiplexed HTS of Serine and Cysteine Proteases
EDWARDS, BRUCE UNIVERSITY OF NEW MEXICO ALBUQUERQUE Assay for Formylpeptide Receptor Family Ligands
FU, HAIAN EMORY UNIVERSITY AlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 Disruptors
GOLDFARB, DAVID S UNIVERSITY OF ROCHESTER Yeast Lifespan Chemical Screening
LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH Chemical Complementation Assay for MKP-1
LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH Chemical Complementation Assay for MKP-3
LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH In Vitro High Throughput Screening Assay for MKP-1
LAZO, JOHN S UNIVERSITY OF PITTSBURGH AT PITTSBURGH In Vitro High Throughput Screening Assay for MKP-3
MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES Cellular Assay for TNF Alpha Induced NF Kappa B Translocation
MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES Cellular Assay for TNF Alpha Induced E-Selectin Expression
MAYER, THOMAS COLUMBIA UNIVERSITY HEALTH SCIENCES CELLULAR ASSAY:PRESENTATION OF THE ADHESION MOLECUL
MUSTAEV, ARKADY PUBLIC HEALTH RESEARCH INSTITUTE Development of the HTS Assay for E. Coli RNA Polymerase (RNAP)
NISWENDER, COLLEEN M VANDERBILT UNIVERSITY Measurement of GPCR-mediated thallium flux through GIRK Channels
PAUMET, FABIENNE COLUMBIA UNIVERSITY HEALTH SCIENCES Unraveling the Molecular Mechanisms of Phagocytosis
ROTHMAN, JAMES E COLUMBIA UNIVERSITY HEALTH SCIENCES Aggregation and Clearance of Mutant Huntingtin
ROTHMAN, JAMES E COLUMBIA UNIVERSITY HEALTH SCIENCES Regulation of Neurotransmitter Transporter Recycling
SANNA M. GERMANA SCRIPPS RESEARCH INSTITUTE MLSCN HTS Assays R03 - S1P1
TEITLER, MILT ALBANY MEDICAL COLLEGE OF UNION UNIV Human 5HT 1E Serotonin Receptor Drug Development
WALKER, SUZANNE HARVARD UNIVERSITY (MEDICAL SCHOOL) Identification of O-GlcNAc Transferase Inhibitors by HTS
WHITE, E. LUCILE SOUTHERN RESEARCH INSTITUTE High Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase
WILKINSON, KEITH D EMORY UNIVERSITY HTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme
WILLIAMS, DAVID L ILLINOIS STATE UNIVERSITY HTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins
ZHOU, MING COLUMBIA UNIVERSITY HEALTH SCIENCES Small-Molecule Modulators of a Family of Voltage-Dependent Potassium Channels

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Technology Development

Assay Development for High Throughput Molecular Screening (R21)
PAR-10-182
PI Name Institution Name Title
BRUICK, RICHARD K (contact)
HAMZA, IQBAL		 UNIVERSITY OF TEXAS SW MED CTR/DALLAS High Throughput Screen Development for Modulators of Heme Transporters
CARAVAN, PETER D MASSACHUSETTS GENERAL HOSPITAL High throughput assay for fibrin-binding probes
CARSTENS, RUSS PAUL UNIVERSITY OF PENNSYLVANIA High throughput assays for modulators of splicing switches during the EMT
CUNNINGHAM, KYLE W JOHNS HOPKINS UNIVERSITY Assays for Non-selective Cation Channel Inhibitors
DESHAIES, RAYMOND J CALIFORNIA INSTITUTE OF TECHNOLOGY A Screen for Inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases
GARDINER, DONALD L (contact)
BROWN, CHRISTOPHER LESLIE
MCCARTHY, JAMES STANISLAUS
TRENHOLME, KATHARINE RUTH 		QUEENSLAND INSTITUTE OF MEDICAL RESEARCH Assay Development for lead identification of anti-gametocydial agents
GOLDBERG, ALFRED L HARVARD UNIVERSITY (MEDICAL SCHOOL) Assay Development for Screening of Specific IKK alpha Kinase Inhibitors
JARDETZKY, THEODORE S STANFORD UNIVERSITY Development of an IgE:Receptor Fluorescence Assay For High Throughput Screening
JOHNSTON, PAUL A. UNIVERSITY OF PITTSBURGH AT PITTSBURGH HCS Assay to Identify Disruptors of AR-TIF2 Protein-Protein Interactions
LUO, JUN-LI SCRIPPS FLORIDA Assay Development for Screening of Specific IKK alpha Kinase Inhibitors
MARTINEZ-SOBRIDO, LUIS UNIVERSITY OF ROCHESTER Identification of compounds that activate interferon to treat viral infections
MERCOLA, MARK SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE HTS for inhibitors of RBPJ co-repressor complex
ROHATGI, RAJAT STANFORD UNIVERSITY High-throughput imaging of Hedgehog pathway components at the primary cilium
STROSBERG, ARTHUR DONNY SCRIPPS RESEARCH INSTITUTE Development of a HTS assay to screen for inhibitors of HCV core NS3h interactions
SWANSTROM, RONALD I (contact)
JANZEN, WILLIAM PERRY		 UNIVERSITY OF NORTH CAROLINA CHAPEL HILL High Throughput Screen For HIV-1 MA/CA Processing Site Inhibitors
WEAVER, C DAVID VANDERBILT UNIVERSITY An HTS-compatible Assay to Probe Muscarinic Receptor Modulation of the M current
ZHOU, PENGBO WEILL MEDICAL COLLEGE OF CORNELL UNIV Development of high throughput assays to identify small molecule inhibitors of the CLR4 ubiquitin ligase

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Assay Development for High Throughput Molecular Screening (R21)
PAR-08-024
PI Name Institution Name Title
ADES, SARAH E PENNSYLVANIA STATE UNIVERSITY-UNIV PARK Assay Development for Inhibitors of the Essential sRNA-Sigma E Virulence Factors
ALDRICH, COURTNEY C UNIVERSITY OF MINNESOTA TWIN CITIES A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
BALCH, WILLIAM EDWARD (Contact)
CONKRIGHT, JULIANA J 		UNIV OF MASSACHUSETTS MED SCH WORCESTER HTS Approach to Correction of Alpha-1-Antitrypsin Misfolding Disease
BEINBORN, MARTIN NEW ENGLAND MEDICAL CENTER HOSPITALS Identification of Class B GPCR Modulators Using Hypersensitive Receptor Probes
BEREZOVSKA, OKSANA MASSACHUSETTS GENERAL HOSPITAL Development of a HTS assay for modulators of presenilin 1 conformation
BERG, LESLIE J (Contact);
ANDREOTTI, AMY;
KANG, JOONSOO		 NEW ENGLAND MEDICAL CENTER HOSPITALS Screening for inhibitors of the T cell Tec Kinase (lTK)
BRAUTIGAN, DAVID L UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Triple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C
BRENMAN, JAY (contact)
SEXTON, JONATHAN ZACHARY		 UNIVERSITY OF NORTH CAROLINA CHAPEL HILL HTS assay development to identify regulators of peroxisome biogenesis/function
BURANDA, TIONE UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Development of HTS Assays for Inhibitors of Viral-Cell Interactions
BURRIS, THOMAS P SCRIPPS RESEARCH INSTITUTE Development and Validation of a REV-ERBalpha HTS Assay
BURRIS, THOMAS P SCRIPPS RESEARCH INSTITUTE Development of a High Throughput Screening Assay for RORgamma
BURRIS, THOMAS P SCRIPPS RESEARCH INSTITUTE Development of an HTS assay to identify FXR antagonists
BUSHWELLER, JOHN HACKETT UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screening for Inhibitors for ERG in Prostate Cancer
CASTILLA, LUCIO H UNIV OF MASSACHUSETTS MED SCH WORCESTER Identification of CBFB-MYH11 specific inhibitors for acute myeloid leukemia
CHAUDHARY, PREET M UNIVERSITY OF PITTSBURGH AT PITTSBURGH Small Molecule Inhibitors of K13-Induced NF-kB Activation
CHEN, YUAN CITY OF HOPE/BECKMAN RESEARCH INSTITUTE High Throughput Assays to Identify Inhibitors of SUMO-mediated Protein-Protein Interactions
CHENG, XIAODONG UNIVERSITY OF TEXAS MEDICAL BR GALVESTON High throughput assay for novel pharmacological probes Targeting cAMP signaling
CHO, CHARLES YOON-HYUNG NOVARTIS INST FOR FUNCTIONAL GENOMICS Screen for Small Molecule Regulators of Retinal Progenitor Epithelial Cell Phagocytosis
CHUANG, TSUNG-HSIEN BURNHAM INSTITUTE FOR MEDICAL RESEARCH Cell-based assay for high-throughput screening of TLR3 activators
CHUNG, WOOK JOON UNIVERSITY OF ALABAMA AT BIRMINGHAM A Novel HTS Cell-Based Imaging Assay to Identify Chemical Correctors for deltaF508-CFTR
CUI, LIWANG PENNSYLVANIA STATE UNIVERSITY-UNIV PARK Development of a cell-based method for high-throughput drug screening in malaria
DEITERS, ALEXANDER NORTH CAROLINA STATE UNIVERSITY RALEIGH High-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
DENTON, JEROD S VANDERBILT UNIVERSITY Chemical probes of the astroglial potassium channel Kir4.1
DIAMOND, SCOTT, (contact)
BLOBEL, GERD A		 UNIVERSITY OF PENNSYLVANIA Development of a Cell-Based Screen for Inhibitors of the FOG-1-NuRD Interaction
DUERKSEN-HUGHES, PENELOPE J LOMA LINDA UNIVERSITY HTS Screening for Inhibitors of HPV 16 E6/Caspase 8 Binding
ENGEL, DANIEL A. (Contact)
BARIC, RALPH S		 UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Yeast Based Assays for Chemical Screens Against SARS-CoV Target
ENGEL, JUAN C UNIVERSITY OF CALIFORNIA SAN FRANCISCO HTS assay for the intracellular stages of T. cruzi, the vector of Chagas disease
FABRIS, DANIELE UNIVERSITY OF MARYLAND BALT CO CAMPUS MS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interaction
FORD, JAMES MATTHEW STANFORD UNIVERSITY A High-Throughput Assay for DNA Repair Activity in the Presence of Aberrant BRCA1
GARDNER, KEVIN H (Contact)
BRUICK, RICHARD K		 UNIVERSITY OF TEXAS SW MED CTR/DALLAS High Throughput Screen Development for Modulators of PAS/Coactivator Interactions
GILMOUR, BRIAN P. RESEARCH TRIANGLE INSTITUTE Screening Assay for Human TAAR1 Ligands
GOBER, JAMES W UNIVERSITY OF CALIFORNIA LOS ANGELES Identification small molecule inhibitors of the bacterial morphogenetic complex
GOCHIN, MIRIAM DR TOURO UNIVERSITY OF CALIFORNIA Assay development for high affinity non-peptide HIV-1 gp41 inhibitors
HASLAM, DAVID B. WASHINGTON UNIVERSITY An HTS Assay For Inhibitors Of C. Difficle Toxins
HODGSON, LOUIS YESHIVA UNIVERSITY High Throughput Screening Assay of Cdc42 Activation in Cancer
HONKANEN, RICHARD E UNIVERSITY OF SOUTH ALABAMA Development of a HTS-assay for inhibitors of a type 2C protein phosphatase (PPMD1/WIP1)
JACKSON, MARY COLORADO STATE UNIVERSITY-FORT COLLINS Assay Development of M. Tuberculosis Class II Aldolase
JIANG, ZHEN YUE BURNHAM INSTITUTE FOR MEDICAL RESEARCH High content screening assay for activators of glucose transporter GLUT4
JEGLA, TIMOTHY J. SCRIPPS RESEARCH INSTITUTE HTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels
KAISER, PETER UNIVERSITY OF CALIFORNIA IRVINE Identification of Small Molecules for Reactivation of p53 Cancer Mutants
KAUFMAN, PAUL D UNIV OF MASSACHUSETTS MED SCH WORCESTER HTS development for targeted anti-fungal small molecules
KAYE, KENNETH M BRIGHAM AND WOMEN'S HOSPITAL Inhibitors of Kaposi’s Sarcoma Herpesvirus
KING, MICHAEL P THOMAS JEFFERSON UNIVERSITY Development of HTS assays for mitochondrial function
KRALLI, ANASTASIA SCRIPPS RESEARCH INSTITUTE A HTS assay for agonists of the orphan nuclear receptor ERRg
LIEBERMAN, PAUL M. WISTAR INSTITUTE Assay Development for Inhibitors of KSHV
LIN, HENING CORNELL UNIVERSITY ITHACA High-throughput assays for the development of SIRT5-specific inhibitors
LUO, MINKUI SLOAN-KETTERING INSTITUTE FOR CANCER RES Developing High Throughput Assay to Identify Protein Methyltransferase Inhibitors
MADDEN, DEAN R DARTMOUTH COLLEGE Small-Molecule Targeting of CFTR:PDZ Trafficking Interactions
MAEGAWA, GUSTAVO HENRIQUE BOFF JOHNS HOPKINS UNIVERSITY A HTS assay to identify molecular probes for arylsulfatase A
MAITRA, RANGAN RESEARCH TRIANGLE INSTITUTE High-throughput Assay to Identify CFTR Inhibitors
MARTIN, THOMAS F. UNIVERSITY OF WISCONSIN MADISON SCREENING FOR INHIBITORS OF VESICLE EXOCYTOSIS
MCDONALD, PATRICIA H. SCRIPPS RESEARCH INSTITUTE A novel approach to enable a HTS-compatible Galanin 3 receptor cell-based assay
MCNEIL, MICHAEL R. COLORADO STATE UNIVERSITY-FORT COLLINS HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
MILLER, SAMUEL I. UNIVERSITY OF WASHINGTON Assay Development for High Throughput Molecular Screening
MUSSER, SIEGFRIED M. TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR High Throughput Screening for Tat Transport Inhibitors
NAPIERALA, MAREK UNIVERSITY OF TEXAS MD ANDERSON CAN CTR Targeting trinucleotide repeats-induced transcriptional silencing in Friedreich's Ataxia
NAPPER, ANDREW ALFRED I. DU PONT HOSP FOR CHILDREN Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
NEUBIG, RICHARD R UNIVERSITY OF MICHIGAN AT ANN ARBOR Assay development for cellular RGS7 family modulators
PANDA, SATCHIDANANDA SALK INSTITUTE FOR BIOLOGICAL STUDIES Melanopsin Photoactivation Assay
PASQUALE, ELENA B BURNHAM INSTITUTE FOR MEDICAL RESEARCH Cell-based screening for EphA2 receptor inhibitors
PAULUS, HENRY (contact)
EMERSON, CHARLES P.		 BOSTON BIOMEDICAL RESEARCH INSTITUTE Identification of inhibitors of hedgehog autoprocessing
PETRUKHIN, KONSTANTIN COLUMBIA UNIVERSITY HEALTH SCIENCES Development of the HTS assay for visual cycle inhibitors
PINTER, ABRAHAM UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL HTS assays for reagents capable of unmasking conserved neutralization sites in HIV-1 Env
POTTER, JAMES DOUGLAS UNIVERSITY OF MIAMI SCHOOL OF MEDICINE HTS for Regulated Muscle Thin Filament Function
PYLE, APRIL D. UNIVERSITY OF CALIFORNIA LOS ANGELES Development of High Content Screens for Human Pluripotent Stem Cells
REITER, JEREMY F
ARKIN, MICHELLE R		 UNIVERSITY OF CALIFORNIA SAN FRANCISCO A novel high content screen for regulators of ciliogenesis and Hedgehog signaling
ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL RNA Targeted Screens of the Prion 5'UTR
ROSEN, HUGH SCRIPPS RESEARCH INSTITUTE HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
ROTH, GREGORY BURNHAM INSTITUTE FOR MEDICAL RESEARCH HTS to Identify Novel Chemical Probes for CCR6
SACKS, DAVID B. BRIGHAM AND WOMEN'S HOSPITAL High throughput screen to identify inhibitors of Salmonella invasion
SATTERTHWAIT, ARNOLD BURNHAM INSTITUTE FOR MEDICAL RESEARCH Development of HTS assays for Bcl-2 converters
SIBLEY, DAVID R. U.S. NATIONAL INST/NEURO/DS/STROKE Functionally-selective ligands for the D2 dopamine receptor
SMITH, HAROLD C OYAGEN, INC. Development of a High Throughput Screen for Antagonists of Vif Dimerization
STRANGE, KEVIN VANDERBILT UNIVERSITY A high throughput screen for inhibitors of nematode detoxification genes
STROSBERG, ARTHUR DONNY SCRIPPS RESEARCH INSTITUTE Novel Assay for Small Molecule Inhibitors of core-NS5A Interaction
SUZUKI, CAROLYN K UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL High throughput screening assays to identify small molecules that target the ClpXP protease
TOBIAS, PETER S SCRIPPS RESEARCH INSTITUTE High Throughput Screening Assays to Identify Inhibitors of TLR4 Signaling
TOMASINI-JOHANSSON, BIANCA UNIVERSITY OF WISCONSIN MADISON Modulators of Fibronectin Fibrillogenesis
TSE-DINH, YUK-CHING NEW YORK MEDICAL COLLEGE HTS assay development targeting Yersinia pestis topoisomerase I
TURK, BENJAMIN E YALE UNIVERSITY Identification of exosite-targeting inhibitors of anthrax lethal factor
WAGNER, ERIC J UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Assay for Compounds that Elicit Misprocessing of Small Nuclear RNA
WAGNER, GERHARD HARVARD UNIVERSITY (MEDICAL SCHOOL) Assays for Discovery of Translation Inhibitors
WALKER, SUZANNE L HARVARD UNIVERSITY (MEDICAL SCHOOL) Cell-based HTS for Compounds that Block Virulence Factor Expression in MRSA
WALSH, KENNETH B UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA Real Time Screening for GIRK1/4 Channel Blockers
WANDINGER-NESS, ANGELA UNIVERSITY OF NEW MEXICO HTS to identify small molecules that disrupt Rab GTPase activator and effector protein interactions
WANG, SHAOMENG UNIVERSITY OF MICHIGAN AT ANN ARBOR Discovery of small-molecule inhibitors of the Beta-Catenin / BCL-9 Interaction
WILLIAMS, RICHARD THOMAS ST. JUDE CHILDREN'S RESEARCH HOSPITAL Synergy Screening of BCR-ABL-driven Lymphoid Leukemias
WOODARD, RONALD WESLEY UNIVERSITY OF MICHIGAN AT ANN ARBOR Mining the kds Pathways - New Source of Novel Antibacterial Targets
YAFFE, MICHAEL B (Contact)
FLOYD, SCOTT R		 MASSACHUSETTS INSTITUTE OF TECHNOLOGY High-content screening for modifiers of the DNA damage response
YANG, PRISCILLA LI-NING HARVARD UNIVERSITY (MEDICAL SCHOOL) Development of Cellular Assays of Dengue Virus Infection
ZHANG, QISHENG UNIVERSITY OF NORTH CAROLINA CHAPEL HILL High Throughput Assay Development for ARFGAP Modulators
ZHAO, RICHARD YUQI UNIVERSITY OF MARYLAND BALTIMORE Fission Yeast as a HTS Platform for New Molecular Probes of HIV-1 VPR-Medicated A
ZHONG, TAO P VANDERBILT UNIVERSITY High content assay for zebrafish cardiomyocyte development
ZWEIFACH, ADAM UNIVERSITY OF CONNECTICUT STORRS A High-throughput Screen of Lytic Granule Exocytosis

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Assay Development for High Throughput Molecular Screening (R21) This is a reissue of RFA-RM-07-001
RFA-RM-07-008
PI Name Institution Name Title
ERNST, NANCY LEWIS SEATTLE BIOMEDICAL RESEARCH INSTITUTE A High Throughput Assay to Identify Onhibitors of Trypanosome RNA Editing Ligase
FENG, XU UNIVERSITY OF ALABAMA AT BIRMINGHAM Cell-Based Assays for Identifying Anti-RANK Signaling Agents
GRAEF, ISABELLA A STANFORD UNIVERSITY HTS Assay Development for Modulators of a Nuclear Import/Export Switch
GRANNEMAN, JAMES G WAYNE STATE UNIVERSITY HTS for Novel Activators of Adipocyte and Myocyte Lipolysis
HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Pathway-Specific Inhibitors of Post-Golgi Transport
HAZBUN, TONY (contact) 
DAVISSON, VINCENT JO		 PURDUE UNIVERSITY WEST LAFAYETTE High-throughput Chemotyping of Yeast Signature Strains Reflecting Hsp90 Biology
ILAGAN, MA.XENIA G WASHINGTON UNIVERSITY Screening for Novel Modulators of Notch/RBPjk Interactions
JOHNSON, JEFFREY DALE METABOLEX, INC. High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase
KAO, GARY D UNIVERSITY OF PENNSYLVANIA The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening
KAYE, KENNETH M BRIGHAM AND WOMEN'S HOSPITAL Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
KRANZ, ROBERT G WASHINGTON UNIVERSITY HTS for Cytochrome C Synthesis Pathways
MAITRA, RANGAN RESEARCH TRIANGLE INSTITUTE Anti-inflammatory Assay for Cystic Fibrosis
NIKOLOV, DIMITAR B SLOAN-KETTERING INSTITUTE FOR CANCER RES Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
PETRIE, HOWARD T SCRIPPS RESEARCH INSTITUTE Assay Development and Screening for Notch Agonists
PETRUKHIN, KONSTANTIN COLUMBIA UNIVERSITY HEALTH SCIENCES Development of the HTS Assay for Agonists of the Orphan Nuclear Receptor NR2E3
PRICE, BRENDAN D DANA-FARBER CANCER INSTITUTE Identification of Inhibitors of the Tip60 Histone Acetyltransferase
REICHMAN, MELVIN LANKENAU INSTITUTE FOR MEDICAL RESEARCH Fructosamine-3-Kinase Assay Development and Validation for HTS
SALVESEN, GUY S BURNHAM INSTITUTE FOR MEDICAL RESEARCH Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs]
WOLF, DIETER A BURNHAM INSTITUTE FOR MEDICAL RESEARCH Optimized High-Throughput Screen for Small Molecule Inhibitors of P27 Degradation
XU, BO SOUTHERN RESEARCH INSTITUTE An HTS Assay for Inhibitors of NBS1-ATM Interactions
ZHOU, JIANHUA UNIV OF MASSACHUSETTS MED SCH WORCESTER Cell Based Assays for Compounds That Regulate Tau Exon 10 Splicing

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Assay Development for High Throughput Molecular Screening (R21) Reissue of RFA-RM-06-004, which was previously released November 2, 2005 RFA-RM-05-011; Reissue for FY2005 of RFA-RM-04-012
RFA-RM-07-001
PI Name Institution Name Title
ARANY, ZOLTAN P. DANA-FARBER CANCER INSTITUTE High throughput screening for modulators of the transcriptional coactivator PGC-1
ARGON, YAIR CHILDREN'S HOSPITAL OF PHILADELPHIA Developing HTS assays for the functions of the chaperone GRP94
BLENIS, JOHN HARVARD UNIVERSITY (MEDICAL SCHOOL) Development of a high content cell based screen for inhibitors of the mTOR signal
CLARDY, JON HARVARD UNIVERSITY (MEDICAL SCHOOL) Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
CLEARY, MICHAEL Lq STANFORD UNIVERSITY Inhibitors of MLL-Menin Interaction
DUTTA, ANINDYA UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Screen for TIP60 Inhibitors
FIDOCK, DAVID A YESHIVA UNIVERSITY A cell-based HTS for delayed death inhibitors of the malarial parasite plastid
GERACE, LARRY R SCRIPPS RESEARCH INSTITUTE Screen for Small Molecule Inhibitors of Nuclear Protein Import
GINSBERG, MARK H UNIVERSITY OF CALIFORNIA SAN FRANCISCO Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
GOCHIN, MIRIAM TOURO UNIVERSITY CALIFORNIA High-Throughput Screening for Human Immunodeficiency Virus Fusion Inhibitors
HARRIS, JASON B MASSACHUSETTS GENERAL HOSPITAL Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
HODDER, PETER SIMMONS SCRIPPS RESEARCH INSTITUTE HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry
HUANG, QIHONG WISTAR INSTITUTE A Cell-based Screen for Small Molecule Modulators of the miRNA Pathway
JAIN, ANJALI CEDARS-SINAI MEDICAL CENTER Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
JARDETZKY, THEODORE S NORTHWESTERN UNIVERSITY Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
KAMPF, J PATRICK FFA SCIENCES, LLC An HTS Assay for the Discovery of Specific Inhibitors of Adipocyte FABP
LAVAN, BRIAN METABOLEX, INC. High Throughput Screening for Identification of AKR1C3 Inhibitors
LI, RONGBAO SOUTHERN RESEARCH INSTITUTE HTS Assay Development for Discovery of Specific PYK2 Inhibitors
PETERSON, JEFFREY R INSTITUTE FOR CANCER RESEARCH Allosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1
PIAZZA, GARY A SOUTHERN RESEARCH INSTITUTE A Novel HTS Cell-Based Assay For Cyclic GMP
ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL MLSN Screen of the PD Alpha Synuclein 5'UTR
ROGERS, MICHAEL S CHILDREN'S HOSPITAL BOSTON Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1
RYDER, SEAN PATRICK UNIV OF MASSACHUSETTS MED SCH WORCESTER Small molecule effectors of maternal gene expression in C. elegans embryogenesis
SANDER, CHRIS SLOAN-KETTERING INSTITUTE FOR CANCER RES High-throughput identification of compounds that modulate the TGF-beta pathway
SMITH, LAYTON H BURNHAM INSTITUTE FOR MEDICAL RESEARCH HTS to identify chemical probes of the apelin receptor signaling pathway
WUTTKE, DEBORAH S UNIVERSITY OF COLORADO AT BOULDER Development of a HTS Assay Targeting End Protection of Telomeres

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Assay Development for High Throughput Molecular Screening (R03/R21) Reissue for FY2006 of RFA-RM-05-011
RFA-RM-06-004
PI Name Institution Name Title
AGAISSE, HERVE F YALE UNIVERSITY SCHOOL OF MED High-throughput screen for compounds affecting intracellular pathogen infection
AIKEN, CHRISTOPHER R VANDERBILT UNIVERSITY Discovering Novel Inhibitors of HIV-1 Maturation
AYAD, NAGI G SCRIPPS FLORIDA RESEARCH INSTITUTE Small-molecule Inhibitors of Wee1 Degradation and Mitotic Entry
BALK, STEVEN P BETH ISRAEL DEACONESS MEDICAL CENTER HTS for Androgen Receptor Antagonists that Recruit NCoR
BOTTINI, NUNZIO LA JOLLA INST FOR ALLERGY & IMMUNOLGY Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors
BROWN, STEVEN J SCRIPPS RESEARCH INSTITUTE Development of a High Throughput Screening Galanin 3 Receptor Assay
CRAWFORD, BRETT E ZACHARON PHARMACEUTICALS, INC. Development of cell-based assays for discovery of GIcNAc-TV inhibitors
CUNNINGHAM, KYLE W JOHNS HOPKINS UNIVERSITY Assays for compounds that block or stimulate yeast cell death
DAY, BILLY W UNIVERSITY OF PITTSBURGH AT PITTSBURGH High Throughput/Content Screens for Dynein Inhibitors
DELISA, MATTHEW P CORNELL UNIVERSITY A cell-based screen for inhibitors of intracellular Abeta aggregation
DENTON, JEROD S VANDERBILT UNIVERSITY Identification of novel modulators of ROMK K+ channel activity
DESHMUKH, MOHANISH P UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Chemical Probes for Uncovering Differential Regulators of Apoptosis in Cells
DJABALLAH, HAKIM SLOAN-KETTERING INSTITUTE FOR CANCER RES Novel & Selective Small Molecular Inhibitors of Human Peptide Deformylase
HODGSON, LOUIS UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Screening for RhoC Activation and its modulation by GEFs
HOFFMANN, F. MICHAEL UNIVERSITY OF WISCONSIN MADISON An HTS Assay for Inhibitors of Smad-dependent Transcriptional Responses to TGF-beta
HOGENESCH, JOHN B UNIVERSITY OF PENNSYLVANIA A Dual Transcriptional and High Content Assay for Cryptochrome
HUGHES, ROBERT E BUCK INSTITUTE FOR AGE RESEARCH A cell-based screen for small molecule binders of mutant huntingtin messenger RNA
JEGLA, TIMOTHY J SCRIPPS RESEARCH INSTITUTE Development of HTS Assays for Sub-Threshold Potassium Channels
JOHNSON, GARY L UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Inhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease
KHANNA, PYARE L DISCOVERX CORPORATION HTS Technology for Discovery of Drugs Targeting GPCR Oligomers
LANDICK, ROBERT C UNIVERSITY OF WISCONSIN MADISON High-Throughput Identification of RNA polymerase inhibitors in vivo
LEISNER, TINA M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Developing HTS Assays for Novel Intracellular Regulators of Integrin Activation
LEVINE, FRED BURNHAM INSTITUTE FOR MEDICAL RESEARCH High-Throughput Screen for Beta-Cell Replication
LINDER, MAURINE E WASHINGTON UNIVERSITY Assay Development to Identify Palmitoylation Inhibitors of Neuronal Proteins
LUO, HONGBO R CHILDREN'S HOSPITAL BOSTON High throughput screening for inhibitors of Akt plasma membrane translocation.
MARZLUFF, WILLIAM F UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Screen for molecules inhibiting histone pre-mRNA processing
MCNEIL, MICHAEL R COLORADO STATE UNIVERSITY-FORT COLLINS Glucosamine-1-phosphate and serine acetylases: HTS assays and configurations
NETTLES, KENDALL W SCRIPPS RESEARCH INSTITUTE Assay Development for Identification of ER-NFkB Pathway Selective Agents
NEUBIG, RICHARD R UNIVERSITY OF MICHIGAN Multiplexed flow cytometry screens for RGS inhibitors
NIKOLOVSKA-COLESKA, ZANETA THE UNIVERSITY OF MICHIGAN Discovery and characterization of novel small molecule inhibitors of Mcl-1
PADGETT, RICHARD A CLEVELAND CLINIC FOUNDATION Screen for Small Molecule Inhibitors of Mammalian Spliceosomes
PERRIMON, NORBERT HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput screening assay development for axonopathic neurodegeration
SALAVATI, REZA MCGILL UNIVERSITY RNA as the catalyst for screening drugs against trypanosomatids
THACHER, SCOTT M ORPHAGEN PHARMACEUTICALS Small Molecule Screen for Circadian and Metabolic Transcription Factors
TRAYNELIS, STEPHEN F EMORY UNIVERSITY Identification of protease activated receptor-2 modulators
WAHLESTEDT, CLAES SCRIPPS RESEARCH INSTITUTE Assay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor
WEISS, ERIC L NORTHWESTERN UNIVERSITY Development of a robust high throughput assay for the discovery of RAM network inhibitors
WELLS, JAMES A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Activators of Procaspase-7
WESSLING-RESNICK, MARIANNE HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) Fluorescence-based screen to probe hepcidin-ferroportin interactions
WILLIAMSON, JAMES R SCRIPPS RESEARCH INSTITUTE HTS for Discovery of Inhibitors of STAR Protein-RNA complexes
XIE, XINMIN SIMON SRI INTERNATIONAL Development of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR
ZHU, MICHAEL X OHIO STATE UNIVERSITY High throughput screening of ligands of TRP channels

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Assay Development for High Throughput Molecular Screening (R03/R21) Reissue of RM-04-012
RFA-RM-05-011
PI Name Institution Name Title
BACHER, ADELBERT TECHNICAL UNIVERSITY MUNICH HTS on Riboflavin and Terpene Biosynthetic Enzymes
CAFFREY, MICHAEL S UNIVERSITY OF ILLINOIS AT CHICAGO High Throughput Screening of HIV Entry Inhibitors
CARTEGNI, LUCA SLOAN-KETTERING INSTITUTE FOR CANCER RES Development of HTS Assays to Identify Specific Alternative Splicing Modulators
CHRISTENSEN, KENNETH A CLEMSON UNIVERSITY Assay for Molecules that Inhibit Anthrax Intoxication and Pathological Angiogenes
CLARDY, JON C HARVARD UNIVERSITY (MEDICAL SCHOOL) Phenotypic-based High Throughput Screens for Plasmodium Falciparum Malaria
CRAWFORD, BRETT E ZACHARON PHARMACEUTICALS, INC. Cell-Based Screen for Inhibitors of Mucin-Type O-Linked Glycans
CUEVAS, BRUCE D UNIVERSITY OF NORTH CAROLINA CHAPEL HILL MEKK2/3-MEK5 Protein Interaction/Activation/ERK5 Pathway
DELPIRE, ERIC J VANDERBILT UNIVERSITY Identification of Novel Modulators of CL-dependent Transport Processes via HTS
DEVI, LAKSHMI A MOUNT SINAI SCHOOL OF MEDICINE OF NYU Assay to Screen Ligands that Selectively Activate Opioid Receptor Heterodimers
ENGELMAN, DONALD M YALE UNIVERSITY A High Capacity Screen for Membrane-Active Compounds
GUPTA, VINEET MASSACHUSETTS GENERAL HOSPITAL Developing HTS Assays for Discovery of Small Molecule Regulators of Integrins
JARSTFER, MICHAEL B UNIVERSITY OF NORTH CAROLINA CHAPEL HILL A High Throughput Screen for Telomerase Assembly
KAMPF, J PATRICK TORREY PINES INSTITUTE/MOLECULAR STUDIES A Fluorescent HTS Assay for the Discovery of FABP Binding Inhibitors
KAN, CHEN-CHEN KECK GRADUATE INST OF APPLIED LIFE SCIS Human CD4+ T Cell Based High Throughput Assay for Drug-Resistant HIV-1 Proteases
KATZ, RICHARD A INSTITUTE FOR CANCER RESEARCH GFP-Based Assays to Probe Transcriptional and Post-Transcriptional Controls
KHANNA, PYARE L DISCOVERX CORPORATION HTS Cell Based EFC Assays for GPCR Drug Discovery
LANSBURY, PETER T BRIGHAM AND WOMEN'S HOSPITAL A High-Throughput Assay for SOD1 Aggregation Inhibitors
MARSH-ARMSTRONG, NICHOLAS R KENNEDY KRIEGER RESEARCH INSTITUTE, INC. Photoreceptor Degeneration Assay in Transgenic Xenopus Reporter Line
MCKERROW, JAMES H UNIVERSITY OF CALIFORNIA SAN FRANCISCO High Throughput Assay for Screening Compounds Against T. Brucei
MECSAS, JOAN C TUFTS UNIVERSITY BOSTON Inhibitors of Yersinia Yop Type III Secretion and Translocation
MOHAN, ROYCE UNIVERSITY OF KENTUCKY Novel High Content Vascular Patterning Assay
MORRIS, DAVID G YALE UNIVERSITY High Throughput Molecular Screening for Compounds that Alter Tgfb1 Signaling Tgfb1 Signaling
NISWENDER, COLLEEN M VANDERBILT UNIVERSITY A Direct Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype
PASQUALE, ELENA B BURNHAM INSTITUTE EphA4 Receptor Antagonists for CNS Regeneration
ROGERS, JACK T MASSACHUSETTS GENERAL HOSPITAL Small HTS Molecules Targeting APP 5' Untranslated Region
SCHARENBERG, ANDREW M CHILDREN'S HOSPITAL AND REG MEDICAL CTR TRPM2 HTS Screening Assay Development
SCHMID, MOLLY B KECK GRADUATE INST OF APPLIED LIFE SCIS Genetic-Based Whole Cell Assays for Discovery of Novel Antibacterials
SCHMIDT, WALTER K UNIVERSITY OF GEORGIA HTS-Based Identification of Novel Rce1p Inhibitors
SIDEROVSKI, DAVID P UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Real-Time Fluorescence Assays of RGS Domain GAP Activity
SPERANDIO, VANESSA UNIVERSITY OF TEXAS SW MED CTR/DALLAS Screen for Quorum Sensing Molecular Inhibitors
STIVERS, JAMES T JOHNS HOPKINS UNIVERSITY High Throughput Assay for Topoisomerase Enzyme Targets
STUDER, LORENZ SLOAN-KETTERING INSTITUTE FOR CANCER RES HTS Screen for Neural Differentiation in Human ES Cells
SWAAN, PETER W UNIVERSITY OF MARYLAND BALT PROF SCHOOL High-Throughput Assay for the Intestinal Peptide Transporter
TRUBETSKOY, VLADIMIR S QUINTESSENCE BIOSCIENCES Development of a Robust HTS Assay to Profile Glucuronidation of Small Molecules
WALDMAN, TODD GEORGETOWN UNIVERSITY Isogenic Cell-Based Screens for Cancer - Targeting Oncogenic B-Catenin
WEIS, KARSTEN UNIVERSITY OF CALIFORNIA BERKELEY Using Chemical Biology to Study the Small GTPase Ran
XIE, XINMIN S SRI INTERNATIONAL Development of HTS Assay for K(ATP) Channels Using FLIPR
YE, QI-ZHUANG INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS A Fluorescence Polarization Assay for Methyltransferases
ZACHARIAS, DAVID A UNIVERSITY OF FLORIDA A Cell-Based HT Imaging Assay for Palmitoylation

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High Throughput Molecular Screening Assay Development (R03)
RFA-RM-05-011
PI Name Institution Name Title
BEZPROZVANNY, ILYA B UNIVERSITY OF TEXAS SW MED CTR/DALLAS Screen for blockers of a CaV2.2-Mint-PDZ1 association
BURGESS, RICHARD R UNIVERSITY OF WISCONSIN MADISON LRET-based HT Screening for Inhibitors of Transcription
BURNS, CHARLES G MASSACHUSETTS GENERAL HOSPITAL HTS assay for zebrafish embryonic heart function
CHIOSIS, GABRIELA SLOAN-KETTERING INSTITUTE FOR CANCER RES Development of HTS assays probing Hsp90 inhibition
CHUNG, RAYMOND T MASSACHUSETTS GENERAL HOSPITAL Chemical Genetics to Identify Cellular Regulators of HCV
CLARDY, JON C HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput Screens for P. falciparum Malaria
CONN, P JEFFREY VANDERBILT UNIVERSITY Development of a High Throughput Assay for Allosteric P*
DAVID, SUNIL A UNIVERSITY OF KANSAS LAWRENCE Novel High-throghput Assay for Angiogenesis Inhibitors
FENTON, ROBERT G UNIVERSITY OF MARYLAND BALT PROF SCHOOL High-throughput screen for inhibitors of Mcl-1
FRANK, DAVID A DANA-FARBER CANCER INSTITUTE High Throughput Screening for Modulators of STAT5
GOLDFARB, DAVID S UNIVERSITY OF ROCHESTER Molecular Screen for Lifespan Extension in Yeast
HARSAY, EDINA UNIVERSITY OF KANSAS LAWRENCE Identifying compounds that target post-Golgi secretion
JAYARAMAN, VASANTHI UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON High throughout screening assay for glutamate receptors
KIEFF, ELLIOTT D. BRIGHAM AND WOMEN'S HOSPITAL Screening of Epstein Barr Virus Replication
KIRKEN, ROBERT A UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON Screening for small molecule inhibitors of Stat5
KUTSCH, OLAF UNIVERSITY OF ALABAMA AT BIRMINGHAM A GFP Based HTS Assay for HIV-1 Tat Inhibitors
LITHGOW, GORDON BUCK INSTITUTE FOR AGE RESEARCH C. elegans, Aging and High Throughput Screening
LU, YILING UNIVERSITY OF TEXAS MD ANDERSON CAN CTR Tissue Lysate Arrays for Molecular Screening
MANION, MICHAEL K FRED HUTCHINSON CANCER RESEARCH CENTER Methods to identify BCL-2 ’gain of function“ inhibitors
MORISSEAU, CHRISTOPHE HP UNIVERSITY OF CALIFORNIA DAVIS Cyanohydrin based fluorescent substrates of sEH
PERRIMON, NORBERT HARVARD UNIVERSITY (MEDICAL SCHOOL) High-throughput screen for host factors in Listeria infection
ROSENFELD, STEVEN S COLUMBIA UNIVERSITY HEALTH SCIENCES Development of High Throughput Screening Assays to Targ*
THACHER, SCOTT M ORPHAGEN PHARMACEUTICALS Small Molecular Screen for Thymocyte Drug Target
TORTORELLA, DOMENICO MOUNT SINAI SCHOOL OF MEDICINE OF NYU Luminescent assay to identify ER dislocation inhibitors
TSE-DINH, YUK-CHING NEW YORK MEDICAL COLLEGE Development of a HTS system in E. coli for topoisomeras*
WALDMAN, TODD A GEORGETOWN UNIVERSITY Isogenic Cell-Based Screens for Cancer: Targeting PTEN
WILSON, ROBERT B UNIVERSITY OF PENNSYLVANIA High throughput screen for cyclin D1 inhibitors
WRIGHT, KENNETH L H. LEE MOFFITT CANCER CTR & RESEARCH INS High Throughput H3-K9 Methyltransferase Inhibitor Screen
XIE, SIMON X SRI INTERNATIONAL HTS Assay for Ca 3 T-type Channels Using FLIPR
YAFFE, MICHAEL B MASSACHUSETTS INSTITUTE OF TECHNOLOGY High-Throughput Assay Design for Polo Kinase Inhibitors

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Exploratory Centers for Cheminformatics Research (P20)
RFA-RM-05-012
PI Name Institution Name Title
BRENEMAN, CURTIS M RENSSELAER POLYTECHNIC INSTITUTE Establishment of the RPI Exploratory Center for Cheminformatics
CLEMONS, PAUL A MASSACHUSETTS INSTITUTE OF TECHNOLOGY General Data-analysis Tools to Relate Chemical Diversity to Biological Outcomes
FOX, GEOFFREY C INDIANA UNIVERSITY BLOOMINGTON Chemical Informatics Cyberinfrastructure
HUGHES-OLIVER, JACQUELINE M NORTH CAROLINA STATE UNIVERSITY RALEIGH Comparative and Web-Enabled Virtual Screening
SHEDDEN, KERBY UNIVERSITY OF MICHIGAN AT ANN ARBOR MACE - Michigan Alliance for Cheminformatic Exploration
TROPSHA, ALEXANDER UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Carolina Exploratory Center for Cheminformatics Research

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Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41)
RFA-RM-09-007
PI Name Institution Name Title
AUBE, JEFFREY UNIVERSITY OF KANSAS LAWRENCE Pilot Scale Libraries Inspired by Natural Products
DOEMLING, ALEXANDER SIEGFRIED UNIVERSITY OF PITTSBURGH AT PITTSBURGH Protein protein interaction directed libraries
GUNATILAKA, LESLIE UNIVERSITY OF ARIZONA Diverse Molecular Libraries from Unique Endosymbiotic Fungi
PHILLIPS, ANDREW J UNIVERSITY OF COLORADO AT BOULDER Robust New Chemistries for Heterocycles
SIGMAN, MATTHEW S UNIVERSITY OF UTAH Discovery Based Studies of Medicinally Relevant Pharmacophore Libraries
WILLIAMS, PHILIP UNIVERSITY OF HAWAII AT MANOA Accessing Cyanobacterial Chemical Diversity: A Unique Natural Product Library

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New Methodologies for Natural Products Chemistry (R01)
RFA-RM-09-005
PI Name Institution Name Title
BACHMANN, BRIAN O (contact); MCLEAN, JOHN ALAN VANDERBILT UNIVERSITY New Methodologies for Accelerating Natural Product Discovery
CICHEWICZ, ROBERT HENRY UNIVERSITY OF OKLAHOMA NORMAN Accessing Natural Products from Silent Biosynthetic Pathways
JENSEN, PAUL R UNIVERSITY OF CALIFORNIA SAN DIEGO A sequenced-based approach for improved small molecule discovery
SCHMIDT, ERIC W UNIVERSITY OF UTAH Rapid Screening and Dereplication of Marine Symbiotic Natural Products
TANG, YI UNIVERSITY OF CALIFORNIA LOS ANGELES A Robust Platform for Reconstituting and Engineering Iterative Megasynthases

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Pilot-Scale Libraries for High-Throughput Screening (P41)
RFA-RM-06-003
PI Name Institution Name Title
BAURES, PAUL WILLIAM UNIVERSITY OF TULSA Molecular Libraries from Imidazole-4,5-Dicarboxylic Acid
GEORG, GUNDA I UNIVERSITY OF MINNESOTA TWIN CITIES Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space
GILBERTSON, SCOTT R UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Synthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds
GRAY, NATHANAEL S DANA-FARBER CANCER INSTITUTE Inhibitors of Kinase Activation
HOUGHTEN, RICHARD A TORREY PINES INST FOR MOLECULAR STUDIES Stereochemically /Structurally Diverse Pilot Scale Libra
HOUGHTEN, RICHARD A TORREY PINES INST FOR MOLECULAR STUDIES Highly Diverse and Structurally Varied Heterocyclic Libraries for the MLSMR
KRCHNAK, VIKTOR UNIVERSITY OF NOTRE DAME Combinational synthesis of bisheterocyclic libraries
KWON, OHYUN UNIVERSITY OF CALIFORNIA LOS ANGELES Pilot-Scale Library Production Based on Phosphine Catalysis of Allenes
LAROCK, RICHARD C IOWA STATE UNIVERSITY Heterocyclic /Carbocyclic Libraries for High Throughput
PARKER, MATTHEW A CHEMDIV, INC. New Regions of Diversity Space in Ergot-Based Libraries
SCHROEDER, FRANK CLEMENS BOYCE THOMPSON INST FOR PLANT RESEARCH Arthropod-Based Libraries for High Throughput Screening
SMITH, AMOS B UNIVERSITY OF PENNSYLVANIA Pilot-Scale Libraries for High-throughput Screening (P41)
WEST, LYNDON M UNIVERSITY OF GEORGIA (UGA) “Drug-Like” Marine Natural Products Library
YU, MARVIN S FLUOROUS TECHNOLOGIES, INC. Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries

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Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41) This is a reissue of RFA-RM-05-014
RFA-RM-08-003
PI Name Institution Name Title
GILBERTSON, SCOTT R UNIVERSITY OF TEXAS MEDICAL BR GALVESTON Pilot Scale Libraries Based on Biologically Active Scaffolds
HANSON, PAUL R UNIVERSITY OF KANSAS LAWRENCE Probing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK J UNIVERSITY OF CALIFORNIA DAVIS Complex Heterocycles and Hybrid Strategies for Pilot Scale Libraries
LUESCH, HENDRIK (Contact)
PAUL, VALERIE J		 UNIVERSITY OF FLORIDA Pilot-Scale Libraries of Marine Cyanobacterial Natural Products
MARTIN, STEPHEN UNIVERSITY OF TEXAS AUSTIN Generating Diverse Pilot-Scale Libraries for Screening
MOLANDER, GARY A UNIVERSITY OF PENNSYLVANIA Novel Boronic Acids for Pilot-Scale Screening
REYNOLDS, ROBERT C SOUTHERN RESEARCH INSTITUTE Pilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative
SCHAUS, SCOTT EDWARD BOSTON UNIVERSITY Structural and Sterochemically Diverse Heterocycles for the Small Molecule Reposi
SHEN, BEN UNIVERSITY OF WISCONSIN MADISON Natural Products from Under-explored Microorganisms
TAN, DEREK S SLOAN-KETTERING INSTITUTE FOR CANCER RES Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSMR
WIPF, PETER UNIVERSITY OF PITTSBURGH AT PITTSBURGH Novel Heterocyclic Libraries
WRIGHT, AMY E FLORIDA ATLANTIC UNIVERSITY Production of Pilot Scale Libraries of Marine Natural Products

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Pilot-Scale Libraries for High-Throughput Screening (P41)
RFA-RM-05-014
PI Name Institution Name Title
BURGESS, KEVIN TEXAS A&M UNIVERSITY SYSTEM Evolving Libraries of Bivalent Compounds
HANSON, PAUL R UNIVERSITY OF KANSAS LAWRENCE Probing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK J UNIVERSITY OF CALIFORNIA DAVIS UCD Combinatorial Center - Novel and Diverse Pilot-Scale Library Production
LEE, KUO-HSIUNG UNIVERSITY OF NORTH CAROLINA CHAPEL HILL CHEMICAL DIVERSITY LIBRARIES FROM MEDICINAL PLANTS
PORCO, JOHN A BOSTON UNIVERSITY CHARLES RIVER CAMPUS Generation of Stereochemically and Structurally Complex Chemical Libraries
SCHREIBER, STUART L MASSACHUSETTS INSTITUTE OF TECHNOLOGY Versatile Diversity-oriented Small Molecule Libraries for Chemogenetics
TAN, DEREK S MEMORIAL SLOAN-KETTERING CANCER CENTER Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSCN
WRIGHT, JEFFREY L UNIVERSITY OF NORTH CAROLINA WILMINGTON Diverse Chemical Libraries from Photosynthetic Marine Microalgae

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New Methodologies for Natural Products Chemistry (R01) This is a reissue of RFA-RM-05-013
RFA-RM-08-004
PI Name Institution Name Title
CLARDY, JON HARVARD UNIVERSITY (MEDICAL SCHOOL) Molecule-to-gene approaches to new natural products
PETERS, REUBEN J IOWA STATE UNIVERSITY A Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids
ROMO, DANIEL TEXAS A&M UNIVERSITY SYSTEM New Methods for Simultaneous Arming and SAR Studies of Natural Products

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New Methodologies for Natural Products Chemistry (R01)
RFA-RM-05-013
PI Name Institution Name Title
BURKART, MICHAEL UNIVERSITY OF CALIFORNIA SAN DIEGO Proteomic Methodologies for Polyketide Biosynthesis
DOYLE, DONALD F GEORGIA INSTITUTE OF TECHNOLOGY Natural Product Biosynthesis by Chemical Complementation
HANDELSMAN, JO E UNIVERSITY OF WISCONSIN MADISON Intracellular Screens for Discovery of Natural Products in Metagenomic Libraries
MILLER, MARVIN J UNIVERSITY OF NOTRE DAME Novel Derivatization/Functionalization of Natural Products
ORJALA, JIMMY UNIVERSITY OF ILLINOIS AT CHICAGO Microscale LC-MS and NMR Methodology for Rapid Natural Products Chemistry
WANG, CLAY C UNIVERSITY OF SOUTHERN CALIFORNIA

Platforms for Nonribosomal Peptide Manipulation


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Molecular Libraries Screening Instrumentation (R01)
RFA-RM-08-020
PI Name Institution Name Title
EDWARDS, BRUCE S. UNIVERSITY OF NEW MEXICO Advancing High Throughput Flow Cytometry

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Molecular Libraries Screening Instrumentation (R01)
RFA-RM-04-020
PI Name Institution Name Title
GASCOYNE, PETER R UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER Reconfigurable microfluidic assay platform for molecular Library Screening
KRON, STEPHEN J UNIVERSITY OF CHICAGO Molecular Library Screening By MALDI-TOF Scanning of Functional Peptide Arrays
LARSON, DALE N HARVARD UNIVERSITY (MEDICAL SCHOOL) HTS of Small Molecule-Protein Interactions
LITVINOV, DMITRI UNIVERSITY OF HOUSTON Development of Nanomagnetic Sensor Array For High Throughput Molecular Screening
MA, HAICHING REACTION BIOLOGY CORPORATION Microarraying and Screening Chemical Libraries
PRICE, JEFFREY H BURNHAM INSTITUTE Continuous-Imaging HT Screening Instrument
VO-DINH, TUAN DUKE UNIVERSITY Ultra-High-Throughput Screening (uHTS) Based on Surface-Enhanced Raman Scattering
ZHU, XIANGDONG UNIVERSITY OF CALIFORNIA DAVIS High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays

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Novel Preclinical Tools for Predictive ADME-Toxicology (R21)
RFA-RM-04-023
PI Name Institution Name Title
BENET, LESLIE Z UNIVERSITY OF CALIFORNIA SAN FRANCISCO Transporter-Enzyme Interplay Evaluation via Microfluidic HTS Cell Culture Devices
GANEY, PATRICIA E MICHIGAN STATE UNIVERSITY Gene Expression in Drug-inflammation Models as Predictive of Idiosyncratic ADRs
HAYSTEAD, TIMOTHY A DUKE UNIVERSITY Proteome Mining as a Predicitve Tool of Drug Toxici ty
HOPFINGER, ANTON J CHEM21 GROUP, INC. Novel Descriptors and Informatics Methods for Predictive ADMET Modeling
MA, PETER X UNIVERSITY OF MICHIGAN AT ANN ARBOR Nano Fibers for ADME/Toxicology
MACDONALD, JEFFREY M UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Human Enterohepatic Cell Model for Predictive Toxicology
MACRAE, CALUM A MASSACHUSETTS GENERAL HOSPITAL Zebrafish Assays Predictive for Drug-Induced Cardiac Repolarization Toxicity PS-149
SUMNER, SUSAN J RESEARCH TRIANGLE INSTITUTE Metabolomics: Markers of Drug-Induced Liver Injury
TROPSHA, ALEXANDER E UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Robust computational framework for predictive ADME-Tox Modeling
ZACHAREWSKI, TIMOTHY R MICHIGAN STATE UNIVERSITY Human Stem Cells for Toxicity Screening

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Development of High Resolution Probes for Cellular Imaging

Innovation In Molecular Imaging Probes (R21)
RFA-RM-04-021
PI Name Institution Name Title
BOLSKAR, ROBERT D TDA RESEARCH, INC. Cut Nanotube Capsules for MR Imaging
BOPPART, STEPHEN A UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Magnetomotive Optical Molecular Imaging Probes
BOYLE, TIMOTHY J SANDIA CORP-SANDIA NATIONAL LABORATORIES Flourescent Ceramic Nanoprobes
BULTE, JEFF W JOHNS HOPKINS UNIVERSITY Developing a CEST Reporter Gene
DAYTON, PAUL A UNIVERSITY OF CALIFORNIA DAVIS High-Sensitivity Molecular Imaging with Ultrasound
DOUGLAS, TREVOR MONTANA STATE UNIVERSITY (BOZEMAN) Targeted MRI with Protein Cage Architectures
GAO, JINMING UNIVERSITY OF TEXAS SW MED CTR/DALLAS MFe2O4-Loaded Polymer Micelles as Ultra-Sensitive MR Molecular Probes
HALPERN, HOWARD J UNIVERSITY OF CHICAGO Magnitude Improvement of Molecular Signaling Imaging
KURHANEWICZ, JOHN UNIVERSITY OF CALIFORNIA SAN FRANCISCO Hyperpolarized 13c NMR Studies of Prostate Cancer
MACH, ROBERT H WASHINGTON UNIVERSITY RADIOLABELED PROBES FOR IMAGING CASPASE 3 ACTIVATION
MATTREY, ROBERT F UNIVERSITY OF CALIFORNIA SAN DIEGO Molecular Imaging with Ultrasound Contrast Agents
POMPER, MARTIN G JOHNS HOPKINS UNIVERSITY PSMA-based Gene Reporter-Probe System

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Development of High Resolution Probes for Cellular Imaging (P20)
RFA-RM-04-001
PI Name Institution Name Title
BURGESS, KEVIN TEXAS A&M UNIVERSITY SYSTEM Fluorescent Probes for Multiplexed Intracellular Imaging
DICKSON, ROBERT M GEORGIA INSTITUTE OF TECHNOLOGY Sub-nm dendrimer-metal nanoclusters as ultrabright, mod*
MOERNER, WILLIAM E STANFORD UNIVERSITY Single-Molecule Fluorophores for Cellular Imaging
NIE, SHUMING EMORY UNIVERSITY Bioaffinity Nanoparticle Probes for Bioimaging
PISTON, DAVID W VANDERBILT UNIVERSITY Probes for Quantitative Optical and Electron Microscopy
SIMON, SANFORD M ROCKEFELLER UNIVERSITY Imaging single proteins in vivo with quantum dots
SINGER, ROBERT H YESHIVA UNIVERSITY Light-Activated Gene Expression in Single Cells
TING, ALICE Y MASSACHUSETTS INSTITUTE OF TECHNOLOGY Library-based development of new optical imaging probes
TSIEN, ROGER UNIVERSITY OF CALIFORNIA SAN DIEGO Genetically Targetable Labels For Light and EM


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