High-Risk Research

Program Snapshot

To enhance support for High Risk-High Reward research, the Common Fund has created four unique funding opportunities for scientists with exceptional creativity who propose highly innovative approaches to major contemporary challenges in biomedical research:

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Program Highlights

Jeff GoreMarkus W. Covert
HRHR researchers named as 2013 Allen Distinguished Investigators


Two NIH High Risk – High Reward Investigators, Jeff Gore, a 2012 New Innovator from MIT, and Markus Covert, a 2009 Pioneer from Stanford University, were selected as 2013 Allen Distinguished Investigators.

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Karl DeisserothEdward S. Boyden
Two HRHR researchers awarded world’s largest brain research prize



Americans, Karl Deisseroth, a 2005 Pioneer Awardee, and 2012 Transformative Research Awardee, and Edward S. Boyden, a 2007 New Innovator, and 2012 Transformative Research Awardee and four European scientists were awarded the 2013 prize for their contributions to the development of “optogenetics.”

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Rats Communicate Via Brain-To-Brain Interface
Rats Communicate Via Brain-To-Brain Interface

Miguel A. L. Nicolelis, a 2010 NIH Director’s Pioneer Awardee from Duke University, and his colleagues, have connected the brains of rat pairs through the internet and shown that the rats can share sensory information, acting as a dyad rather than strictly as individuals.

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Comparison of NIH Common Fund High  Risk - High Reward Programs





Early Independence Award
Early Independence Award
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New Innovator Award
New Innovator Award
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Pioneer Award
Pioneer Award
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Transformative R01
Transformative Research Award
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Division of Program Coordination, Planning, and Strategic Initiatives  •  National Institutes of Health  •  Bethesda, Maryland 20892