Speaker Abstracts

Adah Almutairi (University of California San Diego, New Innovator Awardee)
Light-triggered release of drugs in vivo: amplification strategies, response to new wavelengths, and application to a clinical challenge

Jacquin Niles (Massachusetts Institute of Technology, New Innovator Awardee)
Engineering direct control of protein-RNA interactions for synthetic biology and functional genetics applications

Hidde Ploegh (Whitehead Institute for Biomedical Research, Pioneer Awardee)
Single domain antibodies as tools to perturb protein interactions

Alexander Travis (Cornell University, Pioneer Awardee)
From sperm to stroke: the science of tethering enzymes with applications from nanoscale energy production to handheld diagnostics for neural injury

David Markovitz (University of Michigan, Transformative Research Awardee)
Transformative but not the way we planned: new approaches to centromere biology

Leona Samson (Massachusetts Institute of Technology, Pioneer Awardee)
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagene

Bo Huang (University of California, San Francisco; New Innovator Awardee)
Imaging the genome with CRISPR

Peter Margolis (Cincinnati Children's Hospital Medical Center, Transformative Research Awardee, with Michael Seid, Cincinnati Children’s Hospital Medical Center)
A Collaborative Chronic Care Network (C3N) is a peer produced learning health system

Lalita Ramakrishnan (University of Washington, Pioneer Awardee)
Insights into macrophage migration in tuberculosis from the zebrafish

Julia Felippe (Cornell University, New Innovator Awardee)
The identity thief: Silencing of B lymphocyte commitment gene PAX5 is coincident with gene methylation in common variable immunodeficiency

Ram Samudrala (State University of New York at Buffalo, Pioneer Awardee)
Interactomics: computational analysis of novel drug opportunities

John Calarco (Harvard University, Early Independence Awardee)
Interrogating co- and post-transcriptional gene regulation at single neuron resolution

Josh Dubnau (Cold Spring Harbor Laboratory, Transformative Research Awardee)
The transposon storm hypothesis: collateral damage in the brain

Gabriel Kreiman (Harvard Medical School, New Innovator Awardee)
How neural circuits orchestrate the magic of human cognition

Patrick Purdon (Massachusetts General Hospital, New Innovator Awardee)
Neural systems approach to monitoring brain states during general anesthesia and sedation

Sanjay Jain (Johns Hopkins University, New Innovator and Transformative Research Awardee)
Developing a pipeline of bacteria-specific imaging agents

Fernando Camargo (Boston Children's Hospital, New Innovator Awardee)
Barcoding stem cells: surprises, challenges, and perspectives

Andrew Feinberg (Johns Hopkins University, Pioneer Awardee)
Epigenetic stochasticity, phenotype and the environment

Sarah Tishkoff (University of Pennsylvania, Pioneer Awardee)
Integrative genomic studies of evolution and adaptation in Africa

Ivor Benjamin (Medical College of Wisconsin, Pioneer Awardee)
The reductive stress hypothesis and the antioxidant treatment paradox

Susan Rosenberg (Baylor College of Medicine, Pioneer Awardee)
The DNA damage-control network: a new class of cancer genes discovered in bacteria

Chengkai Dai (Jackson Laboratory, New Innovator Awardee)
MEK critically regulates cellular proteome homeostasis via HSF1

Tannishtha Reya (University of California, San Diego; Pioneer Awardee)
Imaging cancer heterogeneity and therapy resistance in real time

Dana Pe'er (Columbia University, New Innovator and Pioneer Awardee)
Computational dissection of phenotypic and functional heterogeneity in cancer

Yvonne Chen (University of California, Los Angeles; Early Independence Awardee)
Engineering smarter and stronger T cells for cancer immunotherapy

Jody Puglisi (Stanford University, Transformative Research Awardee)
The dynamics of translation

Randal Halfmann (University of Texas Southwestern Medical Center, Early Independence Awardee)
Detection and functional characterization of prion-like protein self-assembly

Kerwyn Huang (Stanford University, New Innovator Awardee)
Quantitative imaging of gut microbiota spatial organization

Jin Zhang (Johns Hopkins University, Pioneer Awardee)
Biochemical activity architecture in living cells

Ed Boyden (Massachusetts Institute of Technology, Transformative Research and Pioneer Awardee)
Super-resolution microscopy across arbitrary scales

Xiaoliang (Sunney) Xie (Harvard University, Transformative Research and Pioneer Awardee)
Single cell genomic analyses of circulating tumor cells

Ipsita Banerjee (University of Pittsburgh, New Innovator Awardee)
Systems analysis of human pluripotent stem cells during self renewal and differentiation

Bela Suki (Boston University, Transformative Research Awardee)
Regulatory roles of mechanical fluctuations in biology

Leor Weinberger (Gladstone Institutes, New Innovator and Pioneer Awardee)
Harnessing gene-expression “noise” for therapy

Poster Abstracts

Monday, December 15, 2014 3:00 - 5:00 PM

Murat Acar (Yale University)
Quantitative real-time characterization of single-cell aging: from phenotypes to lifespan

Mark W. Albers (Massachusetts General Hospital)
Innate Immune Pattern Recognition Receptors Connect Genomic Instability with Neurodegeneration

Mark Andermann (Beth Israel Deaconess Medical Center)
Cortical networks guiding hunger-dependent attention to real and imagined food cues

Alexei A. Aravin (California Institute Of Technology)
Trans-generationally inherited RNAs trigger small RNA biogenesis

Yimon Aye (Cornell University)
Deconvoluting redox biology with targeted chemistry

Gabor Balazsi (State University New York Stony Brook)
Stress-response balance drives the evolution of a newcomer network and its host genome

Emily Patricia Balskus (Harvard University)
Biocompatible Chemistry: Interfacing Non-Enzymatic Reactions With Microbial Metabolism

Helen M. Blau and John Ramunas (Stanford University)
Increasing Healthspan by Rapid and Transient Telomere Extension

Erin Elizabeth Carlson (University Of Minnesota)
Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division

Wei Cheng (University Of Michigan)
Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution

Maximilian Diehn (Stanford University)
Deep Sequencing of Circulating Tumor DNA for Personalized Cancer Detection and Monitoring

Jeffrey D. Dvorin (Children's Hospital Corporation)
Essential gene discovery in the malaria parasite Plasmodium falciparum

Aaron Palmer Esser-Kahn (University Of California-Irvine)
Photo-chemical activation of Toll-like Receptors for Designing Vaccine Responses

Conor Lee Evans (Massachusetts General Hospital)
Sensing Oxygen Tension in tissues with Ultrabright "Clickable" Molecular Sensors

Brian J. Feldman (Stanford University)
Using Components of the Circadian Clock to Regulate Stem Cell Fate Decisions

Joseph R. Fetcho (Cornell University)
Imaging the dynamics of neuronal dendrites and synapses in vivo on times scales from seconds to days

Zev Jordan Gartner (University Of California, San Francisco)
Rapid Synthesis of Multiscale and Multicomponent 3D Tissues by Chemically Programmed Assembly

Harvinder Singh Gill (Texas Tech University)
Pollen grains as 'Trojan Horses' for oral vaccination

Andrew P. Goodwin (University Of Colorado)
Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms

Jeff Gore (Massachusetts Institute Of Technology)
Anticipating sudden transitions in biological populations

Chenghua Gu (Harvard Medical School)
New tools for understanding the blood brain barrier

Daniel Alan Heller (Sloan-Kettering Institute for Cancer Research)
Nanoscale Hyperspectral Microscopy Enables 17-Color Imaging and Benchmarks Endolysosomal Maturation in Living Systems

Hongrui Jiang (University Of Wisconsin-Madison)
An Accommodative Contact Lens for Presbyopic Correction

Sundeep Kalantry (University Of Michigan)
Requirement of a Novel Dose-dependent X-linked Factor in X-chromosome Inactivation

Rahul Manu Kohli (University Of Pennsylvania)
Combating Bacterial Drug Resistance by Targeting the Enzymes of Evolution

Wendy Liu (University Of California-Irvine)
Engineering Biomaterials to Modulate the Immune Response to Implants

Minkui Luo (Sloan-Kettering Institute for Cancer Research)
Diverse Epigenetic Roles of Protein Methyltransferases via Nonhistone Methylation

Wei Min (Columbia University)
Seeing molecular vibrations: optical imaging of small molecules for biology and medicine

Amy E. Palmer (University Of Colorado)
Challenging the conventional view of zinc in biology and establishing zinc as a regulator of the transcriptional and metabolic program in cells

Tao Pan (University Of Chicago)
Adaptive translation as a mechanism of stress response in biology

Christian Petersen (Northwestern University)
Wnt/Notum spatial feedback inhibition controls stem cell activity to regulate planarian brain size in a program of reversible regenerative growth

Shelly R. Peyton (University Of Massachusetts Amherst)
Engineered Environments to Understand Breast Cancer Spread and Drug Resistance

Theresa M. Reineke (University Of Minnesota)
Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery

Aravinthan D. Samuel (Harvard University)
Circuit principles of neuronal processing in larval drosophila melanogaster thermotaxis

Glenn-Milo Santos (Public Health Foundation Enterprises)
The Better THAN Study: Targeting Heavy Alcohol use with Naltrexone

Lonnie D Shea and Vadim Backman (Northwestern University)
An in vivo sensor for detection of cancer metastasis

Xiaokun Shu (University Of California, San Francisco)
A rationally-designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo

Derek James Taylor (Case Western Reserve University)
Induction of cancer cell death by selective DNA misincorporation

Wilson Wong (Boston University)
A robust platform for engineering multi-input and multi-output (MIMO) circuits in mammalian cells

Joy Y. Wu (Stanford University)
In Vivo Rescue of the Hematopoietic Niche by Induced Pluripotent Stem Cells

Peng Yin (Harvard Medical School)
DNA probes for highly multiplexed, precisely quantitative, ultra-resolution imaging

Siyang Zheng (Pennsylvania State University)
Circulating tumor cell (CTC) enrichment and analysis enabled by a flexible micro spring array (FMSA) device

Tuesday, December 16, 2014 3:10 - 5:00 PM

Stephen G. Aller (University of Alabama at Birmingham)
The Road to the Structure of CFTR and Pharmacological Correction of the Major Cystic Fibrosis Defect: Is There an Actual Binding Pocket?

Kyle Rouse Allison (Columbia University Health Sciences)
Identifying Isolation Methods for Persistent Bacteria by Linking Transient Molecular Events to Stable Genetic Signals

Gregory M. Alushin (National Heart Lung and Blood Institute)
Structural Basis of the Vinculin–F-Actin Interaction

Maria Barna (Stanford University)
Specialized Ribosomes: A New Frontier in Gene Regulation, Organismal Development, and Evolution

Hans Tomas Bjornsson (Johns Hopkins University)
Histone Deacetylase Inhibition Recovers Neurological Dysfunction in a Mouse Model of Kabuki Syndrome

Edward Bernard Brown (University of Rochester)
Optical Prediction of Metastatic Outcome Using Second Harmonic Generation

Nicolas Emile Buchler (Duke University)
Punctuated Evolution of a Complex Ancestral Cell Cycle by a Viral Protein

Nathan Claude Gianneschi (University of California San Diego)
Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction

Alexander Gimelbrant (Dana-Farber Cancer Institute)
Mechanism and Function of Autosomal Analog of X Inactivation

Vadim N. Gladyshev (Brigham and Women’s Hospital)
How Does Nature Change Lifespan?

Lea Goentoro (California Institute of Technology)
A New β-Catenin/Tcf Binding Site in DNA Mediates Robustness in Gene Regulation

Elissa Anyon Hallem (University of California Los Angeles)
The Neural Basis of Odor-Driven Behavior in Skin-Penetrating Parasitic Nematodes

Thomas Hartung (Johns Hopkins University)
Mapping the Human Toxome by Systems Toxicology

Richard E. Honkanen (University of South Alabama)
Enabling Cholesterol Catabolism in Human Cells

Elaine Hsiao (California Institute of Technology)
Indigenous Bacterial Species from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Michelle C. Janelsins (University of Rochester)
Clinical and Translational Approaches to Cognitive Impairments in Breast Cancer

Megan C. King (Yale University)
The Nuclear Periphery Acts as a Regulator of Recombinatorial Potential

Leonard Lipovich (Wayne State University)
Life, Death, and Function: The Primate-Specific Long Non-Coding RNA Transcriptome

Sebastian Lourido (Whitehead Institute for Biomedical Research)
Understanding the Signaling Architecture of Calcium-Dependent Protein Kinases in Apicomplexan Parasites

Jonathan F. Lovell (State University of New York at Buffalo)
Porphyrin–Phospholipid Liposomes Permeabilized by Near-Infrared Light

Brent Randall Martin (University of Michigan)
Multiscale Chemical Approaches to Map Oxidative Stress

Michael McAlpine (Princeton University)
3D Printed Nano-Bionic Organs

Aaron Samuel Meyer (Massachusetts Institute of Technology)
Adaptor-Layer Integration of RTK Signaling: Basic Understanding and Application to Prediction of Targeted Drug Resistance

Eric Jorge Nelson (Stanford University)
A Novel Approach to Improve Clinical Decision Support and Make Possible Real-Time Epidemiology for Infectious Disease Outbreaks Using Mobile Technology

Gregor Neuert (Vanderbilt University)
Decoding the Noncoding Genome: lncRNA Dynamics and Function in Single Cells

Elizabeth M. Nolan (Massachusetts Institute of Technology)
Proteolysis of a Human Host-Defense Peptide Unmasks Innate Immune Function

Augusto C. Ochoa (Louisiana State University Health Sciences Center)
Therapeutic Modulation of Host Arginine-Associated Metabolic Pathways Disrupts Viral and Host Processes Required for Pathogen Replication and Manifestation of Disease

Carissa Olsen (Fred Hutchinson Cancer Research Center)
Understanding the Biological Importance of Ether-Linked Lipids in Membrane and Organismal Aging

Timothy P. Padera (Massachusetts General Hospital)
Characterizing Lymphatic Micrometastases

Sallie R. Permar (Duke University)
Maternal CD4+ T Cell Responses are Critical for Fetal Survival Following Acute Cytomegalovirus Infection in a Novel Rhesus Macaque Model of Transplacental Cytomegalovirus Transmission

David Pincus (Whitehead Institute for Biomedical Research)
Phosphorylation is Dispensable for Hsf1 Activation and the Heat Shock Response

Yakeel T. Quiroz (Massachusetts General Hospital)
Memory Network Dysfunction as an Early Marker of Preclinical Alzheimer's Disease

Amanda E. Randles (University of California-Lawrence Livermore National Laboratory)
Toward Coupled Multiphysics Models of Hemodynamics on Leadership Systems

Sarah E. Stabenfeldt (Arizona State University-Tempe Campus)
Targeting the Neural Injury via Astrocytic Phenotypic Alterations

David M. Tobin (Duke University)
Interception of Host Angiogenic Signaling Limits Mycobacterial Growth

Leo Q. Wan (Rensselaer Polytechnic Institute)
Inhibition of Cell-Cell Adhesion Randomized Epithelial Chiral Morphogenesis on Micropatterned Surfaces

Lei Yang (University of Pittsburgh at Pittsburgh)
Re-Beat Whole Decellularized Mouse Heart with Human iPS Cell-Derive Cardiovascular Progenitors

Lijie Grace Zhang (George Washington University)
Integrating 3D Bioprinting and Biologically Inspired Nanomaterials for Complex Tissue Regeneration

Haining Zhong (Oregon Health and Science University)
A Comprehensive and Quantitative Thalamocortical Circuit Diagram at the Mesoscopic Level

Xiaolang (Sunney) Xie (Harvard University)
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors

This page last reviewed on January 28, 2015